In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.

           
Emotion Regulation
Depression
Acupuncture anesthesia is beneficial for patients with depression undergoing surgery, as it can help stabilize mood and reduce the emotional impact of surgery.
Anxiety
Acupuncture anesthesia has anxiolytic effects, calming preoperative anxiety, and promoting a more relaxed state for patients before surgery.
Sedation
Acupuncture anesthesia provides sedation, allowing patients to undergo surgery in a tranquil and comfortable state without the need for excessive sedative drugs.
Mood
By regulating the body's natural balance, acupuncture anesthesia can positively influence mood, contributing to a more positive surgical experience.

Acupuncture anesthesia for Emotion Regulation-Depression


PMID Evidence Source Keyword Type
12065003 There is some limited evidence to support the effectiveness of acupuncture, light therapy (for non-seasonal depression), massage therapy, negative air ionisation (for winter depression), relaxation therapy, S-adenosylmethionine, folate and yoga breathing exercises. Med J Aust. 2002 May 20;176(10):S84-96. doi: 10.5694/j.1326-5377.2002.tb04508.x. Depression Review
12143922 BACKGROUND: This article is a critical review of the efficacy of selected alternative treatments for unipolar depression including exercise, stress management techniques, acupuncture, St. J Clin Psychiatry. 2002 Jul;63(7):628-40. doi: 10.4088/jcp.v63n0716. Depression Review
12143922 Initial evidence suggests that acupuncture might be an effective alternative monotherapy for major depression, single episode. J Clin Psychiatry. 2002 Jul;63(7):628-40. doi: 10.4088/jcp.v63n0716. Depression Review
12470444 In all, three manuals were developed for National Institutes of Health (NIH)-funded clinical trials of acupuncture for depression, spasticity in cerebral palsy, and repetitive stress injury. J Altern Complement Med. 2002 Oct;8(5):623-34. doi: 10.1089/107555302320825147. Depression Review
15846693 Acupuncture for depression. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. Depression Review
15846693 This review examined the currently available evidence supporting the use of acupuncture to treat depression. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. Depression Review
15846693 OBJECTIVES: To examine the efficacy and adverse effects of acupuncture for depression. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. Adverse Reactions Depression Review
15846693 The following terms were used: depression, depressive disorder, dysthymic disorder and acupuncture. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. Depression Review
15846693 There was no evidence that medication was better than acupuncture in reducing the severity of depression (WMD 0.53, 95%CI -1.42 to 2.47), or in improving depression, defined as remission versus no remission (RR1.2, 95%CI 0.94 to 1.51). Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. Depression Review
15846693 AUTHORS' CONCLUSIONS: There is insufficient evidence to determine the efficacy of acupuncture compared to medication, or to wait list control or sham acupuncture, in the management of depression. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. Depression Review
15911926 Although relatively few studies have been done on anxiety and depression, several researchers have found acupuncture to be just as effective as or more effective than antidepressants for patients without cancer. Integr Cancer Ther. 2005 Jun;4(2):131-43. doi: 10.1177/1534735405276419. Anxiety Depression Review
16025787 The effectiveness of acupuncture for depression--a systematic review of randomised controlled trials. Acupunct Med. 2005 Jun;23(2):70-6. doi: 10.1136/aim.23.2.70. Depression Review
16025787 OBJECTIVE: To summarise the existing evidence on acupuncture as a therapy for depression. Acupunct Med. 2005 Jun;23(2):70-6. doi: 10.1136/aim.23.2.70. Depression Review
16025787 METHODS: RCTs were included, in which either manual acupuncture or electroacupuncture was compared with any control procedure in subjects with depression. Acupunct Med. 2005 Jun;23(2):70-6. doi: 10.1136/aim.23.2.70. Depression Review
16025787 CONCLUSION: The evidence from controlled trials is insufficient to conclude whether acupuncture is an effective treatment for depression, but justifies further trials of electroacupuncture. Acupunct Med. 2005 Jun;23(2):70-6. doi: 10.1136/aim.23.2.70. Depression Review
16235404 Depression scores HAMD (n=42, WMD -10.41 CI -12.8 to -8.0), HAMD 'not improved' (n=42, RR 0.17 CI 0.1 to 0.5, NNT 2 CI 2 to 3) and ZDS (n=42, WMD -24.25 CI -28.0 to -20.5) significantly favoured the combined acupuncture/antipsychotic treatment group, although results were from single, small studies. Cochrane Database Syst Rev. 2005 Oct 19;(4):CD005475. doi: 10.1002/14651858.CD005475. Depression Review
16899301 A systematic review of randomized controlled trials of acupuncture in the treatment of depression. J Affect Disord. 2007 Jan;97(1-3):13-22. doi: 10.1016/j.jad.2006.06.012. Epub 2006 Aug 8. Depression Review
16899301 This review examined the randomized controlled trials (RCTs) examining the effects of acupuncture treatment of depression. J Affect Disord. 2007 Jan;97(1-3):13-22. doi: 10.1016/j.jad.2006.06.012. Epub 2006 Aug 8. Depression Review
16899301 METHODS: RCTs of the treatment of depression with acupuncture were located using MEDLINE, Allied and Complementary Medicine and the Cochrane Central Register of Controlled Trials. J Affect Disord. 2007 Jan;97(1-3):13-22. doi: 10.1016/j.jad.2006.06.012. Epub 2006 Aug 8. Depression Review
16899301 The odds ratios derived from comparing acupuncture with control conditions within the RCTs suggests some evidence for the utility of acupuncture in depression. J Affect Disord. 2007 Jan;97(1-3):13-22. doi: 10.1016/j.jad.2006.06.012. Epub 2006 Aug 8. Depression Review
16899301 General trends suggest that acupuncture modalities were as effective as antidepressants employed for treatment of depression in the limited studies available for comparison. J Affect Disord. 2007 Jan;97(1-3):13-22. doi: 10.1016/j.jad.2006.06.012. Epub 2006 Aug 8. Depression Review
16899301 CONCLUSIONS: Despite the findings that the odds ratios of existing literature suggest a role for acupuncture in the treatment of depression, the evidence thus far is inconclusive. J Affect Disord. 2007 Jan;97(1-3):13-22. doi: 10.1016/j.jad.2006.06.012. Epub 2006 Aug 8. Depression Review
17515023 The reviewed literature suggests 4 possible mechanisms by which acupuncture could improve the outcome of IVF: modulating neuroendocrinological factors; increasing blood flow to the uterus and ovaries; modulating cytokines; and reducing stress, anxiety, and depression. Altern Ther Health Med. 2007 May-Jun;13(3):38-48. Anxiety Depression Blood Flow Review
18081800 The fourth included RCT used MT as a control condition to evaluate a depression-specific acupuncture treatment. Int J Clin Pract. 2008 Feb;62(2):325-33. doi: 10.1111/j.1742-1241.2007.01553.x. Epub 2007 Dec 11. Depression Review
18081800 This trial provided limited evidence that, in the early stages of treatment, MT is less effective than acupuncture for treating depression, a treatment which itself is not accepted for this condition. Int J Clin Pract. 2008 Feb;62(2):325-33. doi: 10.1111/j.1742-1241.2007.01553.x. Epub 2007 Dec 11. Depression Review
18456339 John's wort (Hypericum perforatum), S-adenosyl-l-methionine (SAMe), and acupuncture have been studied in a series of randomized controlled trials in patients with major depression. J Affect Disord. 2008 Sep;110(1-2):16-26. doi: 10.1016/j.jad.2008.03.015. Epub 2008 May 5. Depression Review
18550177 Is acupuncture beneficial in depression: a meta-analysis of 8 randomized controlled trials? J Affect Disord. 2008 Dec;111(2-3):125-34. doi: 10.1016/j.jad.2008.04.020. Epub 2008 Jun 11. Depression Review
18550177 Acupuncture is a popular complementary and alternative medicine intervention suggested in the treatment of depression, but its effectiveness is uncertain. J Affect Disord. 2008 Dec;111(2-3):125-34. doi: 10.1016/j.jad.2008.04.020. Epub 2008 Jun 11. Depression Review
18550177 This updated meta-analysis was conducted to more precisely assess the beneficial effect of acupuncture in depression therapy. J Affect Disord. 2008 Dec;111(2-3):125-34. doi: 10.1016/j.jad.2008.04.020. Epub 2008 Jun 11. Depression Review
18550177 The following terms were used: acupuncture, acupressure, depression, depressive disorder, clinical trial, and randomized controlled trial. J Affect Disord. 2008 Dec;111(2-3):125-34. doi: 10.1016/j.jad.2008.04.020. Epub 2008 Jun 11. Depression Review
18550177 Our results confirmed that acupuncture could significantly reduce the severity of depression, which was indicated by decreased scores of Hamilton rating scale for depression (HAMD) or Beck Depression Inventory (BDI). J Affect Disord. 2008 Dec;111(2-3):125-34. doi: 10.1016/j.jad.2008.04.020. Epub 2008 Jun 11. Depression Review
18550177 CONCLUSION: Although this meta-analysis might be discounted due to the low quality of individual trials, it supported that acupuncture was an effective treatment that could significantly reduce the severity of disease in the patients with depression. J Affect Disord. 2008 Dec;111(2-3):125-34. doi: 10.1016/j.jad.2008.04.020. Epub 2008 Jun 11. Depression Review
18682338 Acupuncture can have positive effects on depression and anxiety, although evidence is still lacking as to its true efficacy for these conditions. Behav Med. 2008 Summer;34(2):55-64. doi: 10.3200/BMED.34.2.55-64. Anxiety Depression Review
18843730 Maternal massage, compared to non-specific acupuncture (control group), did not significantly decrease the number of women diagnosed with clinical depression immediately post-treatment (one trial, n = 38; risk ratio (RR) 0.80, 95% confidence interval (CI) 0.25 to 2.53) or at final assessment at 10 weeks' postpartum (one trial, n = 32; RR 1.93, 95% CI 0.37 to 10.01). Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006795. doi: 10.1002/14651858.CD006795.pub2. Depression Review
18843730 Acupuncture specifically treating symptoms of depression, compared to non-specific acupuncture, did not significantly decrease the number of women diagnosed with clinical depression immediately post-treatment (one trial, n = 35; RR 0.48, 95% CI 0.11 to 2.13) or at final assessment at 10 weeks' postpartum (one trial, n = 32; RR 0.64, 95% CI 0.06 to 6.39). Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006795. doi: 10.1002/14651858.CD006795.pub2. Depression Review
18843730 AUTHORS' CONCLUSIONS: The evidence is inconclusive to allow us to make any recommendations for massage therapy or depression-specific acupuncture for the treatment of antenatal depression. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD006795. doi: 10.1002/14651858.CD006795.pub2. Depression Review
19288906 Advances of clinical studies on acupuncture treatment of depression. Zhen Ci Yan Jiu. 2008 Dec;33(6):416-9. Depression Review
19288906 An increasing evidence shows that in the treatment of depression, acupuncture therapy is definitely effective. Zhen Ci Yan Jiu. 2008 Dec;33(6):416-9. Depression Review
19288906 In the present paper, the authors follow the methodology of evidence-based medicine to make a systemic summary about acupuncture treatment of depression from 1) different therapeutic methods, such as electroacupuncture, acupuncture combined with psychological comforts, acupuncture combined with medication, etc. Zhen Ci Yan Jiu. 2008 Dec;33(6):416-9. Depression Review
19632725 The purpose of this systematic review with meta-analysis was to evaluate the effectiveness of acupuncture as monotherapy and as an additional therapy in treating various depressive conditions, particularly major depressive disorder (MDD) and post-stroke depression (PSD). J Affect Disord. 2010 Jul;124(1-2):9-21. doi: 10.1016/j.jad.2009.07.005. Epub 2009 Jul 26. Depression Review
19632725 RESULTS: Of 207 clinical studies of acupuncture for various depression retrieved, 113 (54.6%) were on MDD and 76 (36.7%) on PSD. J Affect Disord. 2010 Jul;124(1-2):9-21. doi: 10.1016/j.jad.2009.07.005. Epub 2009 Jul 26. Depression Review
19835133 Meta-analysis on acupuncture for treatment of depression in patients of poststroke. Zhongguo Zhen Jiu. 2009 Jul;29(7):599-602. Depression Review
19835133 OBJECTIVE: To assess therapeutic effect and the safety of acupuncture for treatment of the depression in patients of poststroke. Zhongguo Zhen Jiu. 2009 Jul;29(7):599-602. Depression Review
19835133 METHODS: The clinical research documents in recent 10 years of acupuncture for treatment of depression in patients of poststroke were retrieved, the homogeneity test was used and the effect amount was complicated in the clinical randomized controlled trials (RCT) documents which had been adopted in the Meta-analysis, and furthermore the Meta-analysis was used in the Hamilton Depression Scale (HAMD) score of both acupuncture group and medication group after treatment. Zhongguo Zhen Jiu. 2009 Jul;29(7):599-602. Depression Review
19835133 CONCLUSION: The therapeutic effect of acupuncture for treatment of the depression in patients of poststroke is superior to other common medicine with safety, but it still needs more large sample RCTs to verify. Zhongguo Zhen Jiu. 2009 Jul;29(7):599-602. Depression Review
20091556 Acupuncture for depression. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. Depression Review
20091556 This review examined the currently available evidence supporting the use of acupuncture to treat depression. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. Depression Review
20091556 OBJECTIVES: To examine the effectiveness and adverse effects of acupuncture in the treatment for depression. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. Adverse Reactions Depression Review
20091556 The following terms were used: depression, depressive disorder, dysthymic disorder and acupuncture. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. Depression Review
20091556 A subgroup of participants with depression as a co-morbidity experienced a reduction in depression with manual acupuncture compared with SSRIs (RR 1.66, 95%CI 1.03, 2.68) (three trials, 94 participants). Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. Depression Review
20091556 AUTHORS' CONCLUSIONS: We found insufficient evidence to recommend the use of acupuncture for people with depression. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. Depression Review
20304708 One RCT evaluated the effects of acupuncture in patients with minor depression or anxiety disorders and another RCT examined the effect of acupuncture on migraine patients. Auton Neurosci. 2010 Jun 24;155(1-2):5-13. doi: 10.1016/j.autneu.2010.02.003. Epub 2010 Mar 20. Anxiety Depression Review
20451469 Anxiety, depression and acupuncture: A review of the clinical research. Auton Neurosci. 2010 Oct 28;157(1-2):91-5. doi: 10.1016/j.autneu.2010.04.002. Epub 2010 May 6. Anxiety Depression Review
20451469 Acupuncture is widely used for treatment of anxiety and depression and use is increasing. Auton Neurosci. 2010 Oct 28;157(1-2):91-5. doi: 10.1016/j.autneu.2010.04.002. Epub 2010 May 6. Anxiety Depression Review
20451469 Trials in depression, anxiety disorders and short-term acute anxiety have been conducted but acupuncture interventions employed in trials vary as do the controls against which these are compared. Auton Neurosci. 2010 Oct 28;157(1-2):91-5. doi: 10.1016/j.autneu.2010.04.002. Epub 2010 May 6. Anxiety Depression Review
20597620 This article reviews alternatives to pharmacologic treatments for women suffering from unipolar depression during pregnancy, focusing on exercise therapy, phototherapy, transcranial magnetic stimulation and acupuncture. Womens Health (Lond). 2010 Jul;6(4):565-76. doi: 10.2217/whe.10.27. Depression Review
20605536 A potential role for acupuncture was found in the following cancer symptoms: pain, nausea and vomiting, xerostomia, hot flushes, fatigue, anxiety, depression and insomnia. Auton Neurosci. 2010 Oct 28;157(1-2):96-100. doi: 10.1016/j.autneu.2010.05.001. Insomnia Nausea and Vomiting Anxiety Depression Review
21078263 A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Zhong Xi Yi Jie He Xue Bao. 2010 Nov;8(11):1014-7. doi: 10.3736/jcim20101102. Depression Review
21078263 Clinical and experimental studies show that the onset of effect of acupuncture on depression is more rapid than selective serotonin reuptake inhibitors, a class of antidepressants. Zhong Xi Yi Jie He Xue Bao. 2010 Nov;8(11):1014-7. doi: 10.3736/jcim20101102. Depression Review
21078263 Accordingly, the main pathway of acupuncture analgesia-the endogenous opioid system, is considered a mechanism for rapid onset of acupuncture effects on depression. Zhong Xi Yi Jie He Xue Bao. 2010 Nov;8(11):1014-7. doi: 10.3736/jcim20101102. Depression Review
21138913 Acupuncture for depression?: A systematic review of systematic reviews. Eval Health Prof. 2011 Dec;34(4):403-12. doi: 10.1177/0163278710386109. Epub 2010 Dec 7. Depression Review
21138913 Acupuncture is often advocated as a treatment for depression, and several trials have tested its effectiveness. Eval Health Prof. 2011 Dec;34(4):403-12. doi: 10.1177/0163278710386109. Epub 2010 Dec 7. Depression Review
21138913 In conclusion, the effectiveness of acupuncture as a treatment of depression remains unproven and the authors' findings are consistent with acupuncture effects in depression being indistinguishable from placebo effects. Eval Health Prof. 2011 Dec;34(4):403-12. doi: 10.1177/0163278710386109. Epub 2010 Dec 7. Depression Review
21611904 Secondly, acupuncture can improve the outcome of IVF-ET, and the mechanisms may be related to the increased uterine blood flow, inhibited uterine motility, and the anesis of depression, anxiety and stress. Chin J Integr Med. 2011 May;17(5):386-95. doi: 10.1007/s11655-011-0611-8. Epub 2011 May 25. Anxiety Depression Blood Flow Review
22010777 In one study, acupuncture was found to have favorable but nonsignificant effects on mania and depression outcomes. J Altern Complement Med. 2011 Oct;17(10):881-90. doi: 10.1089/acm.2010.0481. Depression Review
22043692 CONCLUSION: It is concluded that the preponderant diseases of mental and behavioral disorder treated by acupuncture are dementia, withdrawal syndrome, mental retardation, obsessive-compulsive disorder, sleep disorder, gastrointestinal neurosis (gastrointestinal disorders), depression, alcoholism and globus hystericus. Zhongguo Zhen Jiu. 2011 Oct;31(10):937-40. Depression Review
22073894 Development of studies on neurochemical mechanism of acupuncture underlying improvement of depression. Zhen Ci Yan Jiu. 2011 Oct;36(5):383-7. Depression Review
22073894 In the present review, the authors summarize the progress of experimental researches on acupuncture treatment of depression from (1) monoamines neurotransmitters and their receptors, (2) gamma-aminobutyric acid and glutamate, (3) neuropeptide Y, (4) hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-throid axis activities, and (5) brain-derived neurotrophic factor. Zhen Ci Yan Jiu. 2011 Oct;36(5):383-7. Depression Review
22238805 Acupuncture shows some promise as a CAM therapy for depression, but results were mixed. Depression Review
22238805 However, for patients with post-stroke depression, acupuncture was more effective than short-term use of antidepressants. Depression Review
22238805 However, limited evidence supports the use of meditation, relaxation training and/or breathing retraining, and mindfulness-based stress reduction for anxiety, as well as acupuncture for depression. Anxiety Depression Review
22762294 Acupuncture for depression: a review of clinical applications. Can J Psychiatry. 2012 Jul;57(7):397-405. doi: 10.1177/070674371205700702. Depression Review
22762294 While increasing numbers of patients are seeking acupuncture treatment for depression in recent years, there is limited evidence of the antidepressant (AD) effectiveness of acupuncture. Can J Psychiatry. 2012 Jul;57(7):397-405. doi: 10.1177/070674371205700702. Depression Review
22762294 Therefore, we sought to review the efficacy and safety of acupuncture treatment for depression in clinical applications. Can J Psychiatry. 2012 Jul;57(7):397-405. doi: 10.1177/070674371205700702. Depression Review
22762294 Published data suggest that acupuncture, including manual-, electrical-, and laser-based, is a generally beneficial, well-tolerated, and safe monotherapy for depression. Can J Psychiatry. 2012 Jul;57(7):397-405. doi: 10.1177/070674371205700702. Depression Review
22762294 Acupuncture is a potential effective monotherapy for depression, and a safe, well-tolerated augmentation in AD partial responders and nonresponders. Can J Psychiatry. 2012 Jul;57(7):397-405. doi: 10.1177/070674371205700702. Depression Review
22934399 In the present paper, the authors review development of researches on the involvement of 5-HT and its receptor subunits in pain perception, acupuncture analgesia, and other effects of acupuncture (anti-depression, weight-reduction, etc.). Zhen Ci Yan Jiu. 2012 Jun;37(3):247-51. Depression Review
23904069 For most comparisons a single trial contributed data and there were few statistically significant differences between control and intervention groups.In a trial with 38 women maternal massage compared with non-specific acupuncture (control group) did not significantly decrease the number of women with clinical depression or depressive symptomatology immediately post-treatment (risk ratio (RR) 0.80, 95% confidence interval (CI) 0.25 to 2.53; mean difference (MD) -2.30, 95% CI -6.51 to 1.91 respectively). Cochrane Database Syst Rev. 2013 Jul 31;(7):CD006795. doi: 10.1002/14651858.CD006795.pub3. Depression Review
23904069 In another trial with 88 women there was no difference in treatment response or depression remission rates in women receiving maternal massage compared with those receiving non-specific acupuncture (RR 1.33, 95% CI 0.82 to 2.18; RR 1.14, 95% CI 0.59 to 2.19 respectively).In a trial with 35 women acupuncture specifically treating symptoms of depression, compared with non-specific acupuncture, did not significantly decrease the number of women with clinical depression or depressive symptomatology immediately post-treatment (RR 0.47, 95% CI 0.11 to 2.13; MD -3.00, 95% CI -8.10 to 2.10). Cochrane Database Syst Rev. 2013 Jul 31;(7):CD006795. doi: 10.1002/14651858.CD006795.pub3. Depression Review
23904069 However, women who received depression-specific acupuncture were more likely to respond to treatment compared with those receiving non-specific acupuncture (RR 1.68, 95% CI 1.06 to 2.66).In a trial with 149 women, maternal massage by a woman's significant other, compared with standard care, significantly decreased the number of women with depressive symptomatology immediately post-treatment (MD -6.70, 95% CI -9.77 to -3.63). Cochrane Database Syst Rev. 2013 Jul 31;(7):CD006795. doi: 10.1002/14651858.CD006795.pub3. Depression Review
23904069 AUTHORS' CONCLUSIONS: The evidence is inconclusive to allow us to make any recommendations for depression-specific acupuncture, maternal massage, bright light therapy, and omega-3 fatty acids for the treatment of antenatal depression. Cochrane Database Syst Rev. 2013 Jul 31;(7):CD006795. doi: 10.1002/14651858.CD006795.pub3. Depression Review
24006675 Progress of researches on mechanisms of acupuncture underlying improvement of depression in the past five years. Zhen Ci Yan Jiu. 2013 Jun;38(3):253-8. Depression Review
24006675 In the past five years, a significant progress has been made in understanding the mechanism of acupuncture therapy for improving depression. Zhen Ci Yan Jiu. 2013 Jun;38(3):253-8. Depression Review
24006675 In the present paper, the authors summarize mechanisms of acupuncture for depression from 1) upregulating levels of monoamine neurotransmitters, gamma-aminobutyric acid, 5-HT, receptor binding, and hypothalamic neuropeptide Y, beta-endorphine, and mu-receptor expression, and down-regulating hippocampal glutamate content, etc. Zhen Ci Yan Jiu. 2013 Jun;38(3):253-8. Depression Review
24006675 Moreover, the authors also put forward some suggestions about the further research on the mechanisms of acupuncture intervention for depression in the future. Zhen Ci Yan Jiu. 2013 Jun;38(3):253-8. Depression Review
24138020 Acupuncture as a substitute for standard care was not found to be cost-effective unless comorbid depression was included. Pain Pract. 2014 Sep;14(7):599-606. doi: 10.1111/papr.12116. Epub 2013 Oct 21. Depression Review
24215924 Acupuncture has traditionally been used for problems including anxiety, insomnia, stress, and depression in China and other East Asian countries. Int Rev Neurobiol. 2013;111:197-216. doi: 10.1016/B978-0-12-411545-3.00010-9. Insomnia Anxiety Depression Review
24501113 Acupuncture is being adopted by cancer patients for a wide range of cancer-related symptoms including highly prevalent psychological symptoms like depression, anxiety, insomnia, and impairment in quality of life. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24501113 All published studies that met our review criteria demonstrate a positive signal for acupuncture for the treatment of depression, anxiety, sleep disturbance, and for improving quality of life with most results showing statistical significance. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24501113 However, there are only a handful of acupuncture studies that were specifically designed to evaluate depression, sleep disturbance, and quality of life as primary outcomes, and no studies were found that looked at anxiety as a primary outcome in this population. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24501113 In conclusion, results are encouraging for the development of randomized trials to directly evaluate the therapeutic impact of acupuncture in cancer-related psychological symptoms, including depression, anxiety, sleep disturbance, and quality of life, but attention to acupuncture methodological specific challenges in the development of high-quality research is necessary. Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. Insomnia Anxiety Depression Review
24636189 Evidence has demonstrated that acupuncture may be of benefit in stroke rehabilitation, parkinsonism, dementia, and depression. Cell Transplant. 2014;23(4-5):559-66. doi: 10.3727/096368914X678463. Epub 2014 Mar 11. Depression Review
24698678 Progress of animal research on electro-acupuncture treatment for depression( big up tri, open). Chin Med Sci J. 2014 Mar;29(1):43-7. doi: 10.1016/s1001-9294(14)60023-7. Depression Review
24698678 This paper summarized the Chinese literatures in the previous 5 years about the pre-clinical animal researches on the application of electro-acupuncture (EA) treatment for depression, searched in China National Knowledge Infrastructure (CNKI). Chin Med Sci J. 2014 Mar;29(1):43-7. doi: 10.1016/s1001-9294(14)60023-7. Depression Review
24724890 The treatment programs in China have used traditional herbal approaches as well as acupuncture, often in combination with Western medications such as fluoxetine for depression associated with ATS abuse. Am J Addict. 2014 May-Jun;23(3):313-7. doi: 10.1111/j.1521-0391.2014.12116.x. Depression Review
24818503 In the treatment of post-stroke spastic paralysis, cognitive disorder and depression with acupuncture therapy, modern neuroanatomical knowledge should be one of the key theoretical basis and new therapeutic techniques should be explored and developed continuously. Zhen Ci Yan Jiu. 2014 Apr;39(2):164-8. Depression Review
24852795 In this review, we present evidence regarding the underlying biology of post-stroke depression, commonalities between post-stroke depression and Major Depressive Disorder and explore several treatment approaches, including antidepressant therapy, psychotherapy, surgical therapy, electroconvulsive therapy, acupuncture, music therapy and natural products. Curr Neurovasc Res. 2014;11(3):279-89. doi: 10.2174/1567202611666140522123504. Depression Review
25518120 Of the 13 papers, 6 involve acupuncture analgesia, 2 moxibustion analgesia, 3 mild cognitive impairment, one involves stroke, and the rest one is for depression. Zhen Ci Yan Jiu. 2014 Oct;39(5):418-21. Depression Review
25704563 The benefit of combined acupuncture and antidepressant medication for depression: A systematic review and meta-analysis. J Affect Disord. 2015 May 1;176:106-17. doi: 10.1016/j.jad.2015.01.048. Epub 2015 Jan 28. Depression Review
25704563 Accumulating evidence suggests that acupuncture may also be beneficial in depression, although its effectiveness remains uncertain in this condition. J Affect Disord. 2015 May 1;176:106-17. doi: 10.1016/j.jad.2015.01.048. Epub 2015 Jan 28. Depression Review
25704563 Our results confirmed that the pooled standardized mean difference of the 'endpoint scores of the 17-item Hamilton rating scale for depression' was -3.74 (95% CI, -4.77 to -2.70, p<0.001) in week 1 and -2.52 (95% CI, -4.12 to -0.92; p<0.01) in week 6, indicating a significant difference in favor of acupuncture combined with selective serotonin reuptake inhibitors (SSRIs). J Affect Disord. 2015 May 1;176:106-17. doi: 10.1016/j.jad.2015.01.048. Epub 2015 Jan 28. Depression Review
25704563 More high-quality randomized clinical trials are needed to evaluate the clinical benefit and long-term effectiveness of acupuncture in the treatment of depression. J Affect Disord. 2015 May 1;176:106-17. doi: 10.1016/j.jad.2015.01.048. Epub 2015 Jan 28. Depression Review
25796668 In addition, RCTs supported the use of acupuncture as an adjunctive therapy in chronic obstructive pulmonary disease and in moderate to severe depression. Harefuah. 2015 Jan;154(1):9-15, 70. Depression Review
26007331 Schizophrenia and Depression: A systematic Review of the Effectiveness and the Working Mechanisms Behind Acupuncture. Explore (NY). 2015 Jul-Aug;11(4):281-91. doi: 10.1016/j.explore.2015.04.004. Epub 2015 Apr 28. Depression Review
26007331 OBJECTIVE: This systematic review assessed clinical evidence for the use of acupuncture as an add-on treatment in patients with depression and schizophrenia and for its underlying working mechanisms. Explore (NY). 2015 Jul-Aug;11(4):281-91. doi: 10.1016/j.explore.2015.04.004. Epub 2015 Apr 28. Depression Review
26007331 STUDY SELECTION: Systematic reviews and meta-analyses of acupuncture treatment for depression and schizophrenia were considered for inclusion. Explore (NY). 2015 Jul-Aug;11(4):281-91. doi: 10.1016/j.explore.2015.04.004. Epub 2015 Apr 28. Depression Review
26007331 DATA EXTRACTION: The primary and secondary aims of this study were to evaluate the effects of acupuncture in treating patients with depression or schizophrenia and the possible working mechanisms underlying acupuncture through a systematic literature review. Explore (NY). 2015 Jul-Aug;11(4):281-91. doi: 10.1016/j.explore.2015.04.004. Epub 2015 Apr 28. Depression Review
26007331 DATA SYNTHESIS: The overall clinical results on using acupuncture to treat depression are promising, but only limited evidence for its effectiveness in treating schizophrenia was found. Explore (NY). 2015 Jul-Aug;11(4):281-91. doi: 10.1016/j.explore.2015.04.004. Epub 2015 Apr 28. Depression Review
26007331 CONCLUSIONS: From the evidence found in this study, acupuncture seems to be an effective add-on treatment in patients with depression and, to a lesser degree, in patients with schizophrenia, but large well-designed studies are needed to confirm that evidence. Explore (NY). 2015 Jul-Aug;11(4):281-91. doi: 10.1016/j.explore.2015.04.004. Epub 2015 Apr 28. Depression Review
26970732 A potential role was found for massage and bright light therapy for depression in those with Bulimia Nervosa and a potential role for acupuncture and relaxation therapy, in the treatment of State Anxiety, for those with an eating disorder. Eat Behav. 2016 Apr;21:179-88. doi: 10.1016/j.eatbeh.2016.03.002. Epub 2016 Mar 6. Anxiety Depression Review
27377488 The potential of acupuncture to allay opioid-associated depression and anxiety, and its possible use as an adjuvant treatment were evident. East Asian Arch Psychiatry. 2016 Jun;26(2):70-6. Anxiety Depression Review
27905811 What have researchers found about how antidepressants compare with talk therapy (also called counseling) and other depression treatments (exercise programs, acupuncture, and dietary supplements)? Depression Review
28121095 AIM: Our aim was to establish the most reliable evidence on the clinical effectiveness and cost-effectiveness of acupuncture for chronic pain by drawing on relevant evidence, including recent high-quality trials, and to develop fresh evidence on acupuncture for depression. Depression Review
28121095 To extend the evidence base we synthesised the results of published trials using robust systematic review methodology and conducted a randomised controlled trial (RCT) of acupuncture for depression. Depression Review
28121095 In a RCT of acupuncture or counselling compared with usual care for depression, in which half the patients were also experiencing comorbid pain, we found acupuncture and counselling to be clinically effective and acupuncture to be cost-effective. Depression Review
28121095 Promising clinical and economic evidence on acupuncture for depression needs to be extended to other contexts and settings. Depression Review
28805568 Taichi, Qigong, dance, yoga, mindfulness, acupuncture, and other CAM therapies are reviewed and there is some evidence for the following: Taichi in sleep and PDQ39; dance in cognition, apathy, and a mild trend to improved fatigue; yoga in PDQ39; and acupuncture in depression, PDQ39, and sleep. Int Rev Neurobiol. 2017;134:1163-1188. doi: 10.1016/bs.irn.2017.05.037. Epub 2017 Jul 14. Depression Review
29111577 Neural plasticity mediated by acupuncture in other neural disorders, such as Alzheimer's disease, Parkinson's disease, and depression, were also investigated and there is evidence of positive role of acupuncture induced plasticity in these disorders as well. Neuromodulation. 2018 Dec;21(8):762-776. doi: 10.1111/ner.12724. Epub 2017 Nov 7. Depression Review
29595076 Mainly based on the acupuncture's anti-apoptotic efficacy in prevalent neurological disorders, including cerebral ischemia-reperfusion injury, Alzheimer's disease, depression or stress related-modes, spinal cord injuries, etc., this review comes to a conclusion that the anti-apoptotic effect of acupuncture treatment for neurological diseases, evidently reflected through Bcl-2, Bax or caspase expression change, results from regulating mitochondrial or autophagic dysfunction as well as reducing oxidative stress and inflammation. Am J Chin Med. 2018;46(3):515-535. doi: 10.1142/S0192415X1850026X. Epub 2018 Mar 29. Depression Review
29907576 Effectiveness of acupuncture in postpartum depression: a systematic review and meta-analysis. Acupunct Med. 2018 Oct;36(5):295-301. doi: 10.1136/acupmed-2017-011530. Epub 2018 Jun 15. Depression Review
29907576 OBJECTIVE: To assess the clinical effectiveness of acupuncture in the treatment of postpartum depression (PPD). Acupunct Med. 2018 Oct;36(5):295-301. doi: 10.1136/acupmed-2017-011530. Epub 2018 Jun 15. Depression Review
29907576 CONCLUSIONS: Acupuncture appears to be effective for postpartum depression with respect to certain outcomes. Acupunct Med. 2018 Oct;36(5):295-301. doi: 10.1136/acupmed-2017-011530. Epub 2018 Jun 15. Depression Review
29907576 Further high-quality RCTs following standardised guidelines with a low risk of bias are needed to confirm the effectiveness of acupuncture for postpartum depression. Acupunct Med. 2018 Oct;36(5):295-301. doi: 10.1136/acupmed-2017-011530. Epub 2018 Jun 15. Depression Review
30076453 The results showed the positive influence of a therapy with acupuncture on depressive symptoms in both groups M = 7.67, M = 7.95, M = 3.29 and M = 2.29 (p < 0.001) with significant differences (p < 0.01) and an increase in the effect when using additional specific points for treatment of depression (p < 0.01). Nervenarzt. 2018 Sep;89(9):986-993. doi: 10.1007/s00115-018-0576-3. Depression Review
30396632 A systematic review of acupuncture and Chinese herbal medicine for postpartum depression. Complement Ther Clin Pract. 2018 Nov;33:85-92. doi: 10.1016/j.ctcp.2018.08.006. Epub 2018 Aug 28. Depression Review
30423471 Acupuncture reduced the number of women diagnosed with antenatal depression (RR 1.68, 95% CI 1.06-2.66, 1 trial). J Affect Disord. 2019 Feb 15;245:428-439. doi: 10.1016/j.jad.2018.11.054. Epub 2018 Nov 6. Depression Review
30423471 CONCLUSION: Acupuncture, bright light therapy, and massage may reduce antenatal depression. J Affect Disord. 2019 Feb 15;245:428-439. doi: 10.1016/j.jad.2018.11.054. Epub 2018 Nov 6. Depression Review
30535303 Acupuncture has demonstrated beneficial roles in the regulation of gut dysbiosis, intestinal barrier function, visceral hypersensitivity, gut motor dysfunction, depression/anxiety, and pain, all of which are factors that can significantly impact quality of life in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2019 Jun 18;25(7):1129-1139. doi: 10.1093/ibd/izy371. Anxiety Depression Motor Function Review
30672210 We found ear-acupuncture are mainly used in treating nausea and vomiting caused by radiation and chemotherapy (shenmen (TF(4)), jiaogan (AH(6a)), wei (CO(4)), pi (CO(13)), etc), insomnia in the rehabilitation period (xin (CO(15)), pizhixia (AT(4)), shenmen (TF(4)), etc), depression and anxiety (pizhixia (AT(4)), shenmen (TF(4)), pi (CO(13)), wei (CO(4)), xin (CO(15)), gan (CO(12)), etc), and joint pain (pain point), etc. Zhongguo Zhen Jiu. 2018 Nov 12;38(11):1249-54. doi: 10.13703/j.0255-2930.2018.11.031. Insomnia Nausea and Vomiting Anxiety Depression Review
31076901 Due to the multimorphism of cancer pain, certain mind-body therapies acting on anxiety, stress, depression, or mood disturbances (such as massage, acupuncture, healing touch, hypnosis, and music therapy) are efficient on cancer pain. Support Care Cancer. 2019 Aug;27(8):3119-3132. doi: 10.1007/s00520-019-04829-7. Epub 2019 May 11. Cancer Pain Anxiety Depression Mood Review
31257250 Meta-analysis of 19 out of 34 reviews showed the followings: (1) acupuncture had a beneficial effect on the frequency of hot flushes, (2) yoga had a beneficial effect on depression and health-related QOL, (3) mindfulness-based stress reduction (MBSR) had a beneficial effect on anxiety and depression, (4) combination of herbal medicine and chemotherapy synergistically improved clinical outcomes, (5) acupuncture did not show significant effect on the severity of hot flushes and cancer-related pain, (6) yoga was unable to be confirmed as having an effect on cancer-related pain and physical well-being. Yakugaku Zasshi. 2019;139(7):1027-1046. doi: 10.1248/yakushi.18-00215. Anxiety Depression Review
31259837 Traditional Chinese acupuncture and postpartum depression: A systematic review and meta-analysis. J Chin Med Assoc. 2019 Sep;82(9):719-726. doi: 10.1097/JCMA.0000000000000140. Depression Review
31259837 Thus, this study aimed to review the effectiveness of acupuncture in patients with postpartum depression (PPD). J Chin Med Assoc. 2019 Sep;82(9):719-726. doi: 10.1097/JCMA.0000000000000140. Depression Review
31259837 Patients in the acupuncture group had significantly better performances assessed by the Hamilton Depression Scale than those in the control group, and the pooled MD was -1.27 (95% CI: -2.55 to 0.01; p = 0.05, I = 83%) in the random-effect model. J Chin Med Assoc. 2019 Sep;82(9):719-726. doi: 10.1097/JCMA.0000000000000140. Depression Review
31780032 Nine English and Chinese databases were searched and search terms included perimenopause, menopause, depression, Chinese herbal medicine, acupuncture, RCTs, and their synonyms. Complement Ther Med. 2019 Dec;47:102071. doi: 10.1016/j.ctim.2019.03.019. Epub 2019 Mar 28. Depression Review
31780032 For Hamilton Rating Scale of Depression (HRSD) and Kuppermans Index of Menopause, tuina-massage, combined therapy of CHM plus acupuncture showed significant benefits at end of treatment compared to antidepressants. Complement Ther Med. 2019 Dec;47:102071. doi: 10.1016/j.ctim.2019.03.019. Epub 2019 Mar 28. Depression Review
31780032 Either CHM and acupuncture reduced HRSD scores, indicating less severe depression, showing comparable effects to antidepressants. Complement Ther Med. 2019 Dec;47:102071. doi: 10.1016/j.ctim.2019.03.019. Epub 2019 Mar 28. Depression Review
31780032 CONCLUSION: CHM and acupuncture treatment in perimenopause and menopausal women resulted in reduced severity of depression. Complement Ther Med. 2019 Dec;47:102071. doi: 10.1016/j.ctim.2019.03.019. Epub 2019 Mar 28. Depression Review
31801357 Results demonstrated that EA was superior to control treatment (Western medicine, sham-EA, blank control, acupuncture, and acupoint catgut embedding) according to the visual analog scale (VAS) score, frequency of headache attack (Western medicine, sham-EA, blank control), self-rating anxiety scale (SAS [blank control]), self-rating depression score (SDS [Western medicine and blank control]), and clinical efficiency (Western medicine and sham-EA) after treatment (P < 0.05). Am J Chin Med. 2019;47(8):1755-1780. doi: 10.1142/S0192415X19500897. Epub 2019 Dec 4. Anxiety Depression Review
32005059 Moreover, insomnia patients with major depression disorder were not recommended to use only acupuncture treatment. Ann Palliat Med. 2020 Jan;9(1):19-29. doi: 10.21037/apm.2019.11.15. Insomnia Depression Review
32147048 BACKGROUND: The use of acupuncture to treat depression is not uncommon. Complement Ther Med. 2020 Mar;49:102321. doi: 10.1016/j.ctim.2020.102321. Epub 2020 Jan 24. Depression Review
32147048 OBJECTIVE: To describe the recommendations regarding acupuncture in CPGs for depression in adults, and to assess the methodology used to reach them. Complement Ther Med. 2020 Mar;49:102321. doi: 10.1016/j.ctim.2020.102321. Epub 2020 Jan 24. Depression Review
32147048 METHODS: We conducted a scoping review of CPGs for depression management in adults, which performed systematic reviews (SRs) to answer their review questions, were published between January 2014 and May 2018, and assessed the use of acupuncture as a review question. Complement Ther Med. 2020 Mar;49:102321. doi: 10.1016/j.ctim.2020.102321. Epub 2020 Jan 24. Depression Review
32444032 The effectiveness and safety of acupuncture for depression: An overview of meta-analyses. Complement Ther Med. 2020 May;50:102202. doi: 10.1016/j.ctim.2019.102202. Epub 2019 Oct 23. Depression Review
32444032 PURPOSE: To provide an overview of existing meta-analysis (MAs) on the efficacy and safety of acupuncture for depression, and assess the methodological quality and the strength of evidence of the included MAs. Complement Ther Med. 2020 May;50:102202. doi: 10.1016/j.ctim.2019.102202. Epub 2019 Oct 23. Depression Review
32444032 METHODS: We searched MAs of randomized trials that have evaluated the effects of acupuncture on depression in three international and three Chinese databases from their inception until August 2019. Complement Ther Med. 2020 May;50:102202. doi: 10.1016/j.ctim.2019.102202. Epub 2019 Oct 23. Depression Review
32444032 The results of included MAs were conflicting, our meta-analyses found that acupuncture may confer small benefit in reducing the severity of depression by end of treatment than no treatment/wait list/treatment as usual(SMD -0.74, 95% CI -1.06 to -0.41, eight trials, 624 participants), control acupuncture (invasive, non-invasive sham controls) (SMD 0.27, 95% CI -0.51 to -0.04, 20 trials, 1055 participants), antidepressants(Selective serotonin reuptake inhibitors (SSRI)/ Tetracyclic antidepressants(TCAs)) (SMD -0.28, 95% CI -0.46 to -0.10, 30 trials, 3068 participants), acupuncture plus antidepressants versus antidepressants(SSRI/TCAs) (SMD -0.99, 95% CI -1.37 to -0.61, 17 trials, 1110 participants). Complement Ther Med. 2020 May;50:102202. doi: 10.1016/j.ctim.2019.102202. Epub 2019 Oct 23. Depression Review
32444032 Further methodologically rigorous and adequately powered primary studies are needed to confirm the effectiveness of acupuncture for depression. Complement Ther Med. 2020 May;50:102202. doi: 10.1016/j.ctim.2019.102202. Epub 2019 Oct 23. Depression Review
33334118 Does acupuncture combined with antidepressants have a better therapeutic effect on post-stroke depression? A systematic review and meta-analysis. Acupunct Med. 2021 Oct;39(5):432-440. doi: 10.1177/0964528420967675. Epub 2020 Dec 17. Depression Review
33334118 OBJECTIVE: To evaluate the effectiveness of acupuncture combined with antidepressants in the treatment of post-stroke depression (PSD). Acupunct Med. 2021 Oct;39(5):432-440. doi: 10.1177/0964528420967675. Epub 2020 Dec 17. Depression Review
33371816 is first counted, and then, the application and therapeutic mechanisms of acupuncture on the predominant diseases in each category, including obesity, facial paralysis, sciatica, depression, hypertension, asthma, etc., are specifically discussed in this paper. Am J Chin Med. 2021;49(1):1-23. doi: 10.1142/S0192415X21500014. Epub 2020 Dec 26. Depression Review
33522192 Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression. J Tradit Chin Med. 2021 Feb;41(1):6-16. doi: 10.19852/j.cnki.jtcm.2021.01.002. Depression Review
33522192 OBJECTIVE: To evaluate the clinical efficacy and safety of combined acupuncture and Western Medicine in the treatment of post-stroke depression using a meta-analysis. J Tradit Chin Med. 2021 Feb;41(1):6-16. doi: 10.19852/j.cnki.jtcm.2021.01.002. Depression Review
33522192 METHODS: The China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal Database, Chinese Biomedical Literature Database, PubMed, Embase, and the Cochrane Library were searched from their establishment to August 2018 for randomized controlled trials (RCTs) of combined acupuncture and Western Medicine to treat post-stroke depression. J Tradit Chin Med. 2021 Feb;41(1):6-16. doi: 10.19852/j.cnki.jtcm.2021.01.002. Depression Review
33522192 (b) When analyzing Hamilton Depression Scale (HAMD)-17 scores, six trials showed that acupuncture combined with Western Medicine was superior to Western Medicine alone, and could relieve the depressive symptoms of patients. J Tradit Chin Med. 2021 Feb;41(1):6-16. doi: 10.19852/j.cnki.jtcm.2021.01.002. Depression Review
33522192 CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. J Tradit Chin Med. 2021 Feb;41(1):6-16. doi: 10.19852/j.cnki.jtcm.2021.01.002. Adverse Reactions Depression Review
33838089 The results showed that different CAM interventions (acupuncture, Traditional Chinese medicine [TCM], relaxation, Qigong) significantly improved various psychological symptoms (depression, anxiety, stress, sleep quality, negative emotions, quality of life) and physical symptoms (inflammatory factors, physical activity, chest pain, and respiratory function) in COVID-19 patients. Rev Environ Health. 2021 Apr 12;36(3):443-450. doi: 10.1515/reveh-2021-0012. Print 2021 Sep 27. Anxiety Depression Mood Sleep Quality Review
34371213 Efficacy of frequently-used acupuncture methods for specific parts and conventional pharmaceutical interventions in treating post-stroke depression patients: A network meta-analysis. Complement Ther Clin Pract. 2021 Nov;45:101471. doi: 10.1016/j.ctcp.2021.101471. Epub 2021 Aug 4. Depression Review
34371213 BACKGROUND: Acupuncture is considered as an effective alternative treatment for post-stroke depression because of its low side effects and easy availability. Complement Ther Clin Pract. 2021 Nov;45:101471. doi: 10.1016/j.ctcp.2021.101471. Epub 2021 Aug 4. Side Effects Depression Review
34371213 This study compared the effectiveness of different frequently-used acupuncture methods for specific parts in treating post-stroke depression patients by using network meta-analysis. Complement Ther Clin Pract. 2021 Nov;45:101471. doi: 10.1016/j.ctcp.2021.101471. Epub 2021 Aug 4. Depression Review
34517216 Acupuncture for treating chronic stable angina pectoris associated anxiety and depression: A systematic review and meta-analysis. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 BACKGROUND AND OBJECTIVE: Despite that acupuncture is effective in treating anxiety, depression and chronic stable angina pectoris (CSAP), it remains unclear whether acupuncture can treat CSAP, anxiety and depression simultaneously. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 This systematic review and meta-analysis aimed to investigate the efficacy of acupuncture on CSAP-associated anxiety and depression. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 Meta-analysis results showed that acupuncture combined with standard care was more effective in relieving anxiety and depression, reducing angina attack frequency, and angina pain intensity than sham acupuncture with standard care and standard care alone. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 The safety of acupuncture for CSAP-associated anxiety and depression was also high. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34517216 CONCLUSION: Acupuncture may be used as an adjunctive therapy to treat CSAP-associated anxiety and depression. Complement Ther Clin Pract. 2021 Nov;45:101484. doi: 10.1016/j.ctcp.2021.101484. Epub 2021 Sep 8. Anxiety Depression Review
34521233 Of the non-medication-based therapies, exercise, light therapy, yoga, acupuncture, and probiotics have evidence in the treatment of depression, whereas a full review of dietary modifications for depression was out of scope for this article. Int J Psychiatry Med. 2021 Sep;56(5):334-343. doi: 10.1177/00912174211046353. Depression Review
34623754 Efficacy and safety of acupuncture in the treatment of depression: A systematic review of clinical research. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. Depression Review
34623754 Clinical studies have shown that acupuncture is an effective therapy without obvious side effects compared to limited efficacy and adverse reactions of drug therapy, cognitive behavioral therapy, and neuromodulation technology in treating depression. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. Side Effects Adverse Reactions Depression Review
34623754 The objective of this review is to systematically evaluate whether acupuncture therapies for depression are safe and effective in order to provide a high-quality reference for clinical trials of acupuncture. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. Depression Review
34623754 Compared with antidepressants, acupuncture has the advantages of fast onset and long-term efficacy in the treatment of depression, and can enhance the efficacy of antidepressants. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. Depression Review
34623754 Moreover, the efficacy and safety of acupuncture in the treatment of depression maybe related to the qualification of the acupuncturist, the selection of acupoints, and intervention measures. Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. Depression Review
35153276 This review then summarized the mechanisms by which acupuncture treats common conditions including lower back pain (LBP), ischemic stroke, depression, and irritable bowel syndrome (IBS) and it also cited specific acupuncture points for treating these conditions. Biosci Trends. 2022 Mar 11;16(1):73-90. doi: 10.5582/bst.2022.01039. Epub 2022 Feb 10. Depression Review
35504399 A non-linear meta-regression approach with restricted cubic spline was used to investigate the dose-effect relationship between acupuncture sessions and their effects on the Hamilton rating scale for depression (HAMD) score. J Affect Disord. 2022 Aug 1;310:318-327. doi: 10.1016/j.jad.2022.04.155. Epub 2022 May 2. Depression Review
35595611 Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. J Integr Med. 2022 Jul;20(4):305-320. doi: 10.1016/j.joim.2022.05.002. Epub 2022 May 6. Depression Review
35595611 OBJECTIVE: This review aims to provide evidence on whether acupuncture can enhance the therapeutic effectiveness of antidepressants for treating depression, and explore whether acupuncture can reduce the adverse reactions associated with antidepressants. J Integr Med. 2022 Jul;20(4):305-320. doi: 10.1016/j.joim.2022.05.002. Epub 2022 May 6. Adverse Reactions Depression Review
35595611 INCLUSION CRITERIA: RCTs with a modified Jadad scale score >/= 4 were included if they compared a group of participants with depression that received acupuncture combined with antidepressants with a control group that received antidepressants alone. J Integr Med. 2022 Jul;20(4):305-320. doi: 10.1016/j.joim.2022.05.002. Epub 2022 May 6. Depression Review
35595611 Analysis of the 16 RCTs showed that, compared with antidepressants alone, acupuncture along with antidepressants reduced the Hamilton Depression Rating Scale-17 (HAMD-17) scores (standard mean difference [SMD] -0.44, 95% confidence interval [CI] -0.55 to -0.33, P < 0.01; I(2) = 14%), Self-rating Depression Scale (SDS) scores (SMD -0.53, 95% CI -0.84 to -0.23, P < 0.01; I(2) = 79%), and the Side Effect Rating Scale (SERS) scores (SMD -1.11, 95% CI -1.56 to -0.66, P < 0.01; I(2) = 89%). J Integr Med. 2022 Jul;20(4):305-320. doi: 10.1016/j.joim.2022.05.002. Epub 2022 May 6. Side Effects Depression Review
35764526 The paper reviewed the relevant studies on dyspnea treated with acupuncture over the past 20 years, as well as the underlying neuroendocrine mechanism from the perspective of central and peripheral vagus nerves, neurotransmitter, respiratory muscle function and anti-depression-anxiety function. Zhen Ci Yan Jiu. 2022 Jun 25;47(6):559-64. doi: 10.13702/j.1000-0607.20210430. Anxiety Depression Review
35816994 Positive recommendations on the use of acupuncture were identified for 15 symptom areas from 11 countries for: stroke rehabilitation, dysphagia, shoulder pain, motor recovery, walking, balance, spasticity, upper limb extremity impairment, post-stroke pain, central post stroke pain, cognitive disorder, depression, and sleep problems. Phytomedicine. 2022 Sep;104:154297. doi: 10.1016/j.phymed.2022.154297. Epub 2022 Jun 30. Depression Review
36099656 Limited evidence showed inconsistent results on acupuncture for chemotherapy-induced peripheral neuropathy (3 SRs, 6 RCTs), depression and anxiety (3 SRs, 9 RCTs). Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. Anxiety Depression Review
36099656 For neuropathy, depression and anxiety, acupuncture should be used as an option based on individual conditions. Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. Anxiety Depression Review
36099656 More well-designed clinical trials of acupuncture are recommended on cancer-related depression and anxiety, arthralgia, xerostomia, gastrointestinal dysfunction and dysphagia. Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. Anxiety Depression Review
36812735 While for depression, although the data analysis indicated that SAS can decrease depression significantly (Acupuncture: [random effect model, SMD = -1.26, 95% CI = -2.08 to -0.44, p = 0.003] and Acupressure: [random effect model, SMD = -1.42, 95% CI = -2.41 to -0.42, p = 0.005]), relevant evidence was rated as low. Complement Ther Clin Pract. 2023 May;51:101735. doi: 10.1016/j.ctcp.2023.101735. Epub 2023 Feb 13. Depression Review
36949321 At the same time, anti-inflammation seems to be the common biological pathway for the effects of TCM and acupuncture in depression, Alzheimer's disease, and Parkinson's disease. Adv Exp Med Biol. 2023;1411:435-458. doi: 10.1007/978-981-19-7376-5_19. Depression Review
37015141 Does acupuncture treatment have satisfactory clinical efficacy for late-life depression? A systematic review and meta-analysis. Geriatr Nurs. 2023 May-Jun;51:215-221. doi: 10.1016/j.gerinurse.2023.03.008. Epub 2023 Apr 2. Depression Review
37015141 OBJECTIVE: This systematic review and meta-analysis aimed to assess the clinical efficacy of acupuncture in late-life depression (LLD). Geriatr Nurs. 2023 May-Jun;51:215-221. doi: 10.1016/j.gerinurse.2023.03.008. Epub 2023 Apr 2. Depression Review
37161812 The Meta-analysis results showed that compared with medication, acupuncture showed no significant difference at improving Fagerstrom test for nicotine dependence (FTND) score (MD=0.16, 95%CI: -0.08, 0.41), heaviness of smoking index (HSI) score (MD=0.11, 95%CI: -0.13, 0.36), Minnesota nicotine withdrawal scale (MNWS) score (MD=0.12, 95%CI: -0.11, 1.35), questionnaire of smoking urges (QSU) score (MD=-0.30, 95%CI: -2.78, 2.18), Hamilton depression scale (HAMD) score (MD=0.76, 95%CI: -1.54, 3.06), abstinence rate (RR=0.95, 95% CI: 0.82, 1.10) and effective rate (RR=1.01, 95%CI: 0.95, 1.07). Zhongguo Zhen Jiu. 2023 May 12;43(5):575-83. Depression Review
37382085 Currently, there is already evidence of the use of acupuncture for the treatment of nausea and vomiting, fatigue, dry mouth, anxiety, depression, insomnia and pain. J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. Insomnia Nausea and Vomiting Anxiety Depression Review
37382085 METHODS: Structured and organised according to PICO standards, using keywords (""cancer"" OR ""malignant tumour"" OR ""chemotherapy"" OR ""radiotherapy"") AND (""acupuncture"" OR ""electroacupuncture"") AND (""pain"" OR ""nausea"" OR ""vomit"" OR ""fatigue"" OR ""xerostomia"" OR ""insomnia"" OR ""depression"" OR ""neuropathy""). J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. Insomnia Nausea and Vomiting Depression Review
37451171 CBT and acupuncture both were significantly more effective than education in depression severity. J Psychosom Res. 2023 Sep;172:111435. doi: 10.1016/j.jpsychores.2023.111435. Epub 2023 Jul 9. Depression Review
37619716 Efficacy of scalp acupuncture combined with conventional therapy in the intervention of post-stroke depression: A systematic review and meta-analysis. Complement Ther Med. 2023 Oct;77:102975. doi: 10.1016/j.ctim.2023.102975. Epub 2023 Aug 22. Depression Review
38159534 Compared with usual care or other types of care, mindfulness and yoga had excellent effects against perceived stress, anxiety, and depression; self-regulation could reduce perceived stress and anxiety; exercise could reduce perceived stress; acupuncture could reduce the level of depression; mindfulness could improve the TNF-alpha level, and yoga can reduce the level of salivary cortisol and DNA damage. Complement Ther Clin Pract. 2023 Dec 19;54:101803. doi: 10.1016/j.ctcp.2023.101803. Anxiety Depression Review
20824863 The authors report that for both anxiety and depression scores, there was no evidence for a group effect or a group-time effect, but there was for a time effect (in favour of acupuncture). Cochrane Database Syst Rev. 2010 Sep 8;(9):CD007575. doi: 10.1002/14651858.CD007575.pub2. Anxiety Depression Review
23067573 Based on the results of our review, acupuncture appears to be effective for treating headaches and, although more research is needed, seems to be a promising treatment option for anxiety, sleep disturbances, depression and chronic pain. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Insomnia Anxiety Depression Review
23067573 Because acupuncture has been found to be effective in treating several individual conditions that form TSR (that is, insomnia, depression, chronic pain, headaches) and other multiple co-morbidities), it could be potentially advantageous for treating the multi-symptom complex of TSR. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Insomnia Depression Review
23067573 Six high quality reviews including 73 RCTs with 7,986 participants assessed the efficacy of acupuncture in treating patients with depression or depressive disorders. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Depression Review
23067573 These two reports included the two most recent reviews on acupuncture for depression involving 35 and 19 studies, respectively. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Depression Review
23067573 Although more quality research and safety information are needed to determine whether acupuncture is useful in treating TSR components (.that is, PTSD, sexual function, cognitive function, fatigue), the results of our review suggest that acupuncture may be a beneficial or promising treatment for some components (that is., headache, anxiety, sleep disturbances, depression, chronic pain) and not beneficial for others (that is, substance abuse). Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Cognitive Function Insomnia Anxiety Depression Review
23067573 Though more research is needed to determine whether acupuncture is useful in treating anxiety, sleep disturbances, depression and chronic pain, it does seem to be a promising treatment option. Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. Insomnia Anxiety Depression Review
24041861 sham treatment in men and women with depression found insufficient evidence to recommend the use of acupuncture in the treatment of depression. Best Pract Res Clin Obstet Gynaecol. 2014 Jan;28(1):85-95. doi: 10.1016/j.bpobgyn.2013.08.007. Epub 2013 Aug 26. Depression Review
24041861 Active acupuncture was associated with significantly greater response rates in antenatal depression compared to the control acupuncture or massage groups and a greater proportion of postnatal women with fully remitted depression. Best Pract Res Clin Obstet Gynaecol. 2014 Jan;28(1):85-95. doi: 10.1016/j.bpobgyn.2013.08.007. Epub 2013 Aug 26. Depression Review
24041861 A smaller study of electroacupuncture compared to sham acupuncture for the treatment of postnatal depression demonstrated that both treatments were associated with improvement in depression symptoms, with no between-group difference in outcome measures. Best Pract Res Clin Obstet Gynaecol. 2014 Jan;28(1):85-95. doi: 10.1016/j.bpobgyn.2013.08.007. Epub 2013 Aug 26. Depression Review
24322588 A single treatment at 2 Hz electroacupuncture inhibited thermal hypersensitivity for 48 h; a single treatment at 100 Hz electroacupuncture was only effective for 8 h. In an electrophysiological study, 2 Hz electroacupuncture induced long-term depression of C-fiber-evoked potentials in rats with SNL, while 100 Hz electroacupuncture induced long-term potential in SNL rats. Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. Depression Review
24322588 Synaptic long-term depression in the spinal dorsal horn in SNL rats might be involved in the long-lasting analgesia produced by 2 HZ electroacupuncture. Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. Depression Review
24407111 After acupuncture therapy, patients showed improved recovery of motor function, reduced spasticity, relief of post-stroke depression, urinary incontinence or even reduction of infarction sizes. Prog Neurobiol. 2014 Apr;115:246-69. doi: 10.1016/j.pneurobio.2013.12.007. Epub 2014 Jan 7. Depression Urinary Incontinence Motor Function Review
24566146 As for the mechanism of acupuncture in depression, it was reported that EA and manual acupuncture can upregulate expression of hippocampus BDNF protein and mRNA as well as its receptor TrkB. Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. Depression Review
24566146 Focusing on the relationship between special acupoint in special models, there are some indications that acupuncture stimulation at the HT7 acupoint can significantly upregulate the expression of BDNF, than in any other acupoint on a different meridian in either spatial memory-impairment or depression-like behavioral changes model. Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. Depression Review
24716183 Recent advances from published clinical trials have added evidence to support the use of acupuncture for management of symptoms such as pain, nausea and vomiting, xerostomia, hot flashes, fatigue, anxiety, depression, and insomnia. J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. Insomnia Nausea and Vomiting Anxiety Depression Review
24716183 A recent RCT evaluated 80 patients and revealed acupuncture can effectively reduce malignant-related depression and improve the sleep quality of cancer patients. J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. Depression Sleep Quality Review
25097658 Acupuncture has been reported to improve intelligence and ameliorate depression and anxiety in AD patients. Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. Anxiety Depression Review
25379462 Some local acupuncture (針灸 Zhēn Jiǔ) points used include ST6 Jiache, located near the angle of the mandible at the prominence of the masseter muscle, and ST7 Xiaguan, located at the depression between the zygomatic arch and the mandibular notch. J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. Depression Review
25530779 The search required at least one term from each of the following categories: (1) heroin, opiate, and opioid; (2) acupuncture and electroacupuncture; (3) withdrawal syndromes, retention, dropout, completion, positive urine, craving, abstinence, heroin use, depression, anxiety, and relapse. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 We pooled all continuous data from trials according to their control interventions (sham acupuncture, no treatment, or drug) and outcome measures (craving, anxiety, and depression) used. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 All of the four studies published in English language journals did not show favorable effects of acupuncture on psychological symptoms associated with opioid addiction (anxiety, depression, and craving). Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 11 of 12 studies published in Chinese language journals supported use of acupuncture for controlling psychological symptoms associated with opioid addiction: craving, anxiety, and depression. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 Figure 4 reports the results of the meta-analysis of acupuncture for depression associated with opioid addiction. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Depression Review
25530779 The results showed a statistically significant benefit of acupuncture for improving depression symptoms compared with placebo acupuncture (SMD = 2.22, 95% CI: 1.57 to 2.87, and I 2 = 0%) and compared with no treatment also (SMD = 1.99, 95% CI: 1.55 to 2.43, and I 2 = 0%). Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Depression Review
25530779 We identify and summarize the evidence about the possible clinical effectiveness of acupuncture on three psychological symptoms: heroin/opioid craving, depression, and anxiety. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 Our meta-analysis indicated a statistically significant benefit of acupuncture for improving depression and anxiety associated with opioid addiction. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 This raises the possibility that the acupuncture protocols designed for psychological symptoms associated with opioid addiction may be more effective for the treatment of cravings, anxiety, and depression. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Anxiety Depression Review
25530779 The effect of acupuncture on depression (including depressive neurosis and depression following stroke) has been documented repeatedly in controlled studies. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Depression Review
25530779 Meta-analysis of acupuncture for depression associated with opioid addiction. Evid Based Complement Alternat Med. 2014;2014:313549. doi: 10.1155/2014/313549. Epub 2014 Nov 4. Depression Review
25548594 The latest study by means of gene microarray analysis revealed that acupuncture stimulation of GB34 (number 34 of gallbladder meridian, located in the depression anterior and inferior to the head of the fibula of the lateral side of the leg) and LR3 (number 3 of liver meridian, located in the depression of the posterior end of the 1st interosseous metatarsal space of the foot) could modulate the gene expression of the thalamus in model mice with parkinsonism. Evid Based Complement Alternat Med. 2014;2014:950631. doi: 10.1155/2014/950631. Epub 2014 Dec 7. Depression Review
25548594 In another study, manual acupuncture (MA) stimulation of BL60 (number 60 acupoint of bladder meridian located in the center of the depression between the prominence of the lateral malleolus of the fibula and the calcaneal tendon behind the ankle joint) can also elicit activating response in the thalamus. Evid Based Complement Alternat Med. 2014;2014:950631. doi: 10.1155/2014/950631. Epub 2014 Dec 7. Depression Review
26498685 It is important to note that acupuncture did not improve symptoms of depression, whereas a significant improvement in depressive symptoms has been reported in previous studies. Oncotarget. 2015 Nov 24;6(37):39725-39. doi: 10.18632/oncotarget.5388. Depression Review
26823672 (2002) showed the significant improvements in the depression, anxiety, and functional status in all groups but no differences in the specific acupuncture, nonspecific acupuncture, and symptom-based acupuncture groups. Evid Based Complement Alternat Med. 2015;2015:495684. doi: 10.1155/2015/495684. Epub 2015 Dec 28. Anxiety Depression Review
27217981 Trials have also shown that acupuncture significantly alleviates depression, anxiety and stress by modulating both specific and non-specific neurological signalling and also neuromodulators such as cortisol, prolactin, epinephrine and beta endorphin. Curr Obstet Gynecol Rep. 2016;5:110-118. doi: 10.1007/s13669-016-0156-0. Epub 2016 Apr 25. Anxiety Depression Review
27430619 Acupuncture has been widely used to treat a variety of clinical conditions, particularly those involving pathological changes in neuroendocrinology, such as menopause, depression, and insomnia. BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. Insomnia Depression Review
27531549 Acupuncture may help treat specific cancer-related symptoms, including pain, gastrointestinal side effects, hot flushes, fatigue, anxiety, and depression. Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. Side Effects Anxiety Depression Review
27705610 The acupuncture group also showed improvements on measures of cognition and depression not observed in the control group. Nutr Neurosci. 2018 Feb;21(2):79-91. doi: 10.1080/1028415X.2016.1236174. Epub 2016 Oct 5. Depression Review
28286776 The Efficacy of Acupuncture for Treating Depression-Related Insomnia Compared with a Control Group: A Systematic Review and Meta-Analysis Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 To evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 Acupuncture combined with Western medicine (MD = −5.46, CI −8.55 to −2.38) had more effect on improving depression degree compared with the Western medicine alone. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Depression Review
28286776 This systematic review indicates that acupuncture could be an alternative therapy to medication for treating depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 The effect of acupuncture treatment for depression is significant. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Depression Review
28286776 Chan's systematic review and meta-analysis of acupuncture combined with antidepressants for depression showed that acupuncture combined with antidepressants was better than the single use of antidepressants. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Depression Review
28286776 The purpose of this meta-analysis was to evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 Acupuncture is widely used in the treatment of depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 A large number of studies have reported that acupuncture treatment is effective in treating depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 This systematic review and meta-analysis on the acupuncture treatment for depression-related insomnia can find some results. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 In this systematic review and meta-analysis, we further evaluated the effectiveness of acupuncture in the treatment of depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 The flowing search terms were used: acupuncture/electroacupuncture/EA and insomnia/sleep disorders and depression. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 By reading full texts of the published studies, 18 studies were confirmed that they were all randomized controlled trials of acupuncture treating insomnia associated with depression (Table 1), among them 11 articles were RCTs of acupuncture compared with Western medicine; 5 were RCTs of acupuncture combined with medication compared with sole medication; 2 were studies of acupuncture compared with sham or placebo acupuncture control. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 It indicates that the acupuncture treatment was more effective on insomnia and depression than medication (Figure 3). Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 The results showed that the acupuncture combined with medicine group was more effective in improving depression degree than that in sole medication treatment group. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Depression Review
28286776 This systematic review and meta-analysis assessed the effectiveness of acupuncture in treating depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 The object of this systematic review and meta-analysis is to evaluate the effectiveness of acupuncture in treating depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 We found that, compared to medication, acupuncture treatment was effective in improving depression-related insomnia and depression degree. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 In conclusion, research evidence supported the use of acupuncture as an effective treatment to improve symptoms of depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28286776 In addition, the use of acupuncture should be considered an appropriate alternative treatment for depression-related insomnia. Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. Insomnia Depression Review
28358808 The authors concluded that for antenatal depression the evidence is too inconclusive to make any recommendations for depression-specific acupuncture, maternal massage, bright light therapy, and omega-3 fatty acids. PLoS One. 2017 Mar 30;12(3):e0173397. doi: 10.1371/journal.pone.0173397. eCollection 2017. Depression Review
28358808 Two trials examined the role of acupuncture, Manber and colleagues studied depression-specific acupuncture in comparison with non-specific acupuncture and massage therapy (A16-A17). PLoS One. 2017 Mar 30;12(3):e0173397. doi: 10.1371/journal.pone.0173397. eCollection 2017. Depression Review
28358808 A new sample of 150 patients in 2010 showed that women who received acupuncture specific for depression experienced a greater reduction of HDRS-rates, compared with the combined controls or control acupuncture after 8 weeks of treatment (A17). PLoS One. 2017 Mar 30;12(3):e0173397. doi: 10.1371/journal.pone.0173397. eCollection 2017. Depression Review
28358808 For the patients with depression, we grouped the available interventions together in 1) CBT; 2) IPT; 3) bright light therapy; 4) body-oriented therapies; 5) acupuncture; and 6) food supplements (see Fig 3). PLoS One. 2017 Mar 30;12(3):e0173397. doi: 10.1371/journal.pone.0173397. eCollection 2017. Depression Review
28436999 As trials have been conducted on the effects of acupuncture, healing touch, and stress management on depression and improvement in mood, these therapies can be considered (Grades C). CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. Depression Mood Review
28436999 Five trials assessed acupuncture as a treatment for depression/mood (but as a secondary outcome) and only one trial was large, with mixed findings in terms of effect. CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. Depression Mood Review
28664077 In the AMSRC, resultant research articles have shown that acupuncture can improve neurological and psychological problems, including Parkinson's disease, pain, and depression, in animal models. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Depression Review
28664077 Acupuncture has been used for hwa-byung or depression, as well as for treating chronic illnesses and injuries such as back pain, knee osteoarthritis, tension headache, migraine, nausea, and vomiting. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Nausea and Vomiting Depression Review
28664077 Effects of acupuncture on depression and anxiety disorders Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Anxiety Depression Review
28664077 Lee et al reported that acupuncture stimulation at acupoint Neiguan (PC6) significantly reduced chronic CORT-induced depression and anxiety-like behaviors, and increased neuropeptide Y expression in the hypothalamus. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Anxiety Depression Review
28664077 That study suggested that acupuncture may be an effective treatment for stress-related disorders such as depression and anxiety, probably by modulating the HPA axis. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Anxiety Depression Review
28664077 Acupuncture has demonstrated efficacy for treating chronic problems such as pain and depression. Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. Depression Review
28851961 Acupuncture is considered to be a promising alternative therapy for depression. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 Nevertheless, up to now, it remains controversial on the effects exerted by acupuncture on behavioral changes in depression models. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 In conclusion, acupuncture has not less effect on behavior changes than western medicine, including improving NC, NR, RSI, FW and GW in depression models. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 Although confirmed to be a generally safe and well tolerated therapy, the mechanisms underlying the effects of acupuncture on depression have not been fully explained. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 However, effects of acupuncture on behavioral tests including open field test (OFT), sucrose intake test (SIT), and body weight in depression models are controversial in different studies. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 Due to its potential values, such as promoting the conduct and report of basic researches and providing some guidance to translate the achievements of basic researches to clinical application in acupuncture for depression, and so on, we conducted this systematic review and meta-analysis to evaluate effects of acupuncture on behavioral changes in depression model rats. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 Seventy-six included studies provided detailed descriptions about possible mechanisms of acupuncture in behavior changes of depression models. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 The funnel plot of the effects of acupuncture on behavioral changes in experimental depression. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 The present study indicate that compared with western medicine, acupuncture has not less effect on behavior indicators including NC, NR, RSI, FW and GW for depression model rats, but the evidence on whether acupuncture is as effective as western medicine for depression model rats on CSI is insufficient. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 It demonstrates that acupuncture may have a potential disadvantage on improving the appetite of depression model rats in comparison with western medicine. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 Therefore, we consider that acupoints may be the main influencing factor in effecs of acupuncture on symptoms of depression. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 Moreover, some studies had doubt about the effects of acupuncture on these indicators in depression models, which suggesting whether acupuncture has effects on these indicators needs to be resolved. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 A Cochrane review has suggested that there is not enough evidence to demonstrate acupuncture is effective for depression and it has recommended future research should employ comparative designs and compare acupuncture with structured psychotherapies such as standard care. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 We expected that acupuncture may have not less effect than anti-depressants on depression and have an advantage on less side effects, which is helpful for patients to adhere to the treatment. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Side Effects Depression Review
28851961 The mechanisms of acupuncture on depression remain unclear. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28851961 We consider that acupuncture treat depression by multi-targets through neuroendocrine-immune system and the future researches should enlarge the sample size and further clarify the pathophysiological effects of different acuopints or acupoint combinations. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Immunity Depression Review
28851961 We evaluated the methodological quality of the included studies by applying the list of Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Stroke (CAMARADES) which is modified on the basis of the characteristics of acupuncture treatment in depression researches when assessing the quality of studies, the items included: (1) sample size calculation; (2) randomization to treatment group; (3) allocation concealment; (4) blinded assessment of outcome; (5) correctness of methods of modeling; (6) avoidance of anesthetics with resistance to depressive; (7) describing control of temperature; (8) compliance with animal welfare regulations; (9) publication in a peer-reviewed journal; (10) declared any potential conflict of interest. Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. Depression Review
28930222 Results: After the review of literature and the approval of a Regional Resolution, some CM will be introduced in Cancer Departments in Tuscany to additionally treat cancer-related symptoms and side effects of conventional cancer therapy: acupuncture for nausea and post-chemotherapy and post-surgery vomiting, pain, hot flashes of iatrogenic menopause, xerostomia; homeopathy for hot flashes of iatrogenic menopause and the side effects of radiotherapy; herbal medicine for cancer-related fatigue, nausea and vomiting, pain, mucositis, anxiety, and depression. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Side Effects Nausea and Vomiting Anxiety Depression Review
28930222 This paper used a new classification system of effectiveness divided into six levels (A, B, C, D, H, I): acupuncture is assigned grade C (at least a moderate certainty that there is a small benefit) for pain, hot flashes, anxiety, depression, and fatigue. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Anxiety Depression Review
28930222 For acupuncture and TCM, the areas of application are post-chemotherapy and post-surgical nausea and vomiting, pain in all of its phases, vasomotor disturbances of iatrogenic menopause and xerostomia; for homeopathy, the vasomotor disturbances of iatrogenic menopause and adverse effects of radiotherapy; for herbal medicine, cancer-related fatigue, nausea and vomiting, pain, mucositis, anxiety and depression. Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. Adverse Reactions Nausea and Vomiting Anxiety Depression Review
29063107 Finally, although acupuncture can lower repeated short-term reflex elevations in blood pressure for one to two hours, recent studies have focused on experimental hypertension, to demonstrate that repeated sequential application every second or third day can produce blood pressure depression lasting for several days. Sheng Li Xue Bao. 2017 Oct 25;69(5):587-597. Blood Pressure Depression Review
30298094 Real acupuncture performed at point Large Intestine 4 (LI4) of the right hand (r-LI4) was shown to determine significant decreases of HR and LF/HF and a significant increase of HF, indicating a parasympathetic activation as well as sympathetic depression. Evid Based Complement Alternat Med. 2018 Sep 12;2018:8107508. doi: 10.1155/2018/8107508. eCollection 2018. Heart Rate Depression Review
30416533 Acupuncture has proven to be effective for reducing drug addiction and stress-related psychiatric disorders, such as anxiety and depression. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Anxiety Depression Review
30416533 Also, acupuncture has been proven to be an effective treatment for reducing stress, anxiety, and depression via modulation of brain stress and endocrine systems in preclinical and clinical studies. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Endocrinology Anxiety Depression Review
30416533 In contrast, it has been shown that repeated electroacupuncture at Baihui (GV-20) and Yintang (EX-HN3) increased glutamate, 5-hydroxytryptamine (5-HT), and the BDNF-related peptides, such as protein kinase C (PKC) and cyclic adenosine monophosphate response element binding protein, in the hippocampus and inhibited stress-induced depression. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Depression Review
30416533 Acupuncture also has proven to be an effective treatment for reducing stress, anxiety, and depression via modulation of brain stress and endocrine systems in clinical studies. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Endocrinology Anxiety Depression Review
30416533 Based on an association between depression and drug relapse in dependence, these data raise the possibility for acupuncture's role in suppressing drug relapse. Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. Depression Review
30622598 The results showed that acupuncture could be more beneficial than no treatment/sham acupuncture in terms of changes in craving for opioid (MD -2.18, 95% CI -3.10 to -1.26), insomnia (MD 2.31, 95% CI 1.97 to 2.65), and depression (SMD -1.50, 95% CI -1.85 to -1.15). Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Insomnia Depression Review
30622598 In addition, these findings showed that, compared to sham electroacupuncture (EA), EA had differences in alleviating symptoms of craving (SMD -0.50, 95% CI -0.94 to -0.05) and depression (SMD -1.07, 95% CI -1.88 to -0.25) and compared to sham transcutaneous acupoint electrical stimulation (TEAS), TEAS had differences in alleviating symptoms of insomnia (MD 2.31, 95% CI 1.97 to 2.65) and anxiety (MD -1.26, 95% CI -1.60 to -0.92) compared to no treatment/sham TEAS. Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Insomnia Anxiety Depression Review
30622598 The objective of this study is to assess the efficacy of various modes of acupuncture in OUD through intensity of withdrawal syndrome; duration of treatment; urine examination; intensity of pain, anxiety, depression, insomnia, and other associated symptoms; retention of treatment; and nature and rate of adverse effect. Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Adverse Reactions Insomnia Anxiety Depression Review
30622598 just assessed the effect of acupuncture in treatment of psychological symptoms associated with OUD, and both studies agreed that acupuncture could be effective in improving anxiety and depression. Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. Anxiety Depression Review
30762808 Multiple studies have shown that acupuncture has a good therapeutic effect on depression, and can effectively regulate the mental state and behavior of patients and improve their quality of life. Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. Depression Review
30762808 Although the mechanism of acupuncture for PDD is not clear, there is a lot of evidence that acupuncture has a good effect on depression. Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. Depression Review
30762808 Although there is evidence that acupuncture is effective for depression, studies on acupuncture treatment of PDD have not gone far enough. Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. Depression Review
30762808 The study, which will bring together all Chinese and English RCT studies involving different acupuncture methods to treat perimenopausal depression, will provide evidence of efficacy and safety and promote the use of acupuncture for perimenopausal depression. Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. Depression Review
30809158 The Effects of Acupuncture on Glutamatergic Neurotransmission in Depression, Anxiety, Schizophrenia, and Alzheimer's Disease: A Review of the Literature Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 In this review, we investigate the current evidence for the treatment efficacy of acupuncture in depression, anxiety, schizophrenia, and AD. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Numerous clinical reports from various sources, including the non-Western scientific literature, attest to the efficacy of acupuncture in depression, anxiety disorders, schizophrenia, and Alzheimer's disease (AD). Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Acupuncture for the Treatment of Depression Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 The effectiveness of acupuncture in depression has been extensively investigated with various sets of acupuncture points and treatment parameters (e.g., duration, frequency, and number of treatment sessions). Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 A recent Cochrane systematic review that included 64 studies (7,104 participants) examined the effectiveness of acupuncture for the treatment of depression. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 The evidence indicated that acupuncture treatment may moderately or slightly lower the severity of depression compared with treatment as usual and control acupuncture (invasive, non-invasive sham controls), respectively, although the quality of the evidence was judged as being mostly low or very low. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 Other reviews have also described evidence in support of MA and EA as generally beneficial, safe and well-tolerated as monotherapy in MDD and post-stroke depression, but the evidence is insufficient to support the use of acupuncture in combination with antidepressants. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 Two Chinese studies examined the effectiveness of acupuncture and moxibustion (a treatment involving burning of the dried Chinese herb mugwort or Artemesia vulgaris to apply heat onto or very close to an acupoint) in relieving psychological distress in 163 patients with depression and sought to determine whether gender-related differences exist in response to acupuncture and moxibustion. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 Hence, acupuncture treatment in depression may improve depressive symptoms of depression and endure for some months. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 Moreover, sleep status may improve in patients with depression after acupuncture treatment. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 A recent meta-analysis that included 18 randomized clinical trials (RCTs) involved 1,678 adults given acupuncture for depression-related insomnia and found significant improvements in sleep quality with acupuncture compared with Western medicine. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Insomnia Depression Sleep Quality Review
30809158 When acupuncture was given as an adjunctive therapy with Western medicine, both depression and insomnia were improved. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Insomnia Depression Review
30809158 Thus, the psychological effect of acupuncture might play an important role in the treatment of acupuncture in depression-related insomnia. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Insomnia Depression Review
30809158 At the end of acupuncture treatment, urine 6-sulfatoxymelatonin (a metabolite of melatonin) levels were normalized and several polysomnographic measures, as well as self-reported fatigue, sleepiness, anxiety, and level of depression, were significantly improved. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Combined with the evidence of treatment efficacy in depression-related insomnia, acupuncture may have broader utility in neuropsychiatric disorders with impaired quality of sleep. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Insomnia Depression Sleep Quality Review
30809158 These results suggest that verum acupuncture modulates autonomic activity in response to alterations of internal and external environments, and thus reduces overall anxiety in patients with depression or anxiety. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 However, it should be recognized that the interpretation of results from clinical trials investigating acupuncture interventions in depression and anxiety disorders is complicated by different interventions, different comparators used against acupuncture interventions, and the small sample sizes in many trials. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Compared with depression and anxiety, relatively few studies have addressed the efficacy of acupuncture in schizophrenia. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 As with the clinical evidence for acupuncture in depression and anxiety disorders, the clinical evidence is limited for the effectiveness of acupuncture as a treatment for schizophrenia. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 In a US study that included 11 patients with dementia (10 with AD and 1 with vascular dementia), depression and anxiety scores improved significantly after acupuncture treatment. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
30809158 Thus, acupuncture-mediated modulation of EAAT2 expression may ameliorate depression. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Depression Review
30809158 In summary, evidence indicates that acupuncture treatment may be of benefit in several neuropsychiatric disorders, including depression, anxiety, schizophrenia, and AD. Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. Anxiety Depression Review
31016194 Effectiveness of Acupuncture Used for the Management of Postpartum Depression: A Systematic Review and Meta-Analysis Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 However, the use of acupuncture for the treatment of postpartum depression remains controversial. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 This review summarizes the most significant studies in the area of acupuncture treatment for postpartum depression and provides a detailed overview of the efficacy of acupuncture for the treatment of postpartum depression. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 We undertook a systematic review of publicly available electronic databases to identify studies that evaluated acupuncture for the treatment of postpartum depression. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Our meta-analysis selected randomized controlled trials (RCTs) and quasi-RCTs that reported on the treatment effect of acupuncture on postpartum depression. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Alternative treatment strategies for postpartum depression are gaining prominence, especially acupuncture, and has gained acceptance due to its efficacy and safety. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Though several studies have investigated the efficacy of acupuncture on postpartum depression, several of these studies showed inconsistencies in their efficacy. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 There is a need to determine the efficacy of acupuncture particularly in women with postpartum depression. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 In this context, we conducted a systematic review and meta-analysis on published studies to evaluate the efficacy of acupuncture treatment for postpartum depression. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Randomized controlled trials (RCTs) or quasi-RCTs that investigated the effect of acupuncture on postpartum depression women were selected for this study. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Any inconsistencies during the literature search were scrutinized against the following inclusion criteria: (1) randomized control or quasi-randomized control design was essential; (2) all women were diagnosed with postpartum depression; (3) patients received either acupuncture or traditional therapies; (4) available data concerns the effective rate of acupuncture treatment for extraction; (5) the diagnosis criteria of postpartum depression were based on the International Classification of Diseases (ICD), Chinese Classification of Mental Disorders (CCMD), or the Diagnostic and Statistical Manual of Mental Disorders (DSM). Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 As shown in Figure 1, a total of 759 potentially useful relevant studies regarding the effect of acupuncture treatment for postpartum depression were initially identified. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Growing evidence has demonstrated the beneficial effect of acupuncture treatment for postpartum depression. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Therefore, we aimed to further investigate the association between the effect of acupuncture treatment and postpartum depression in this meta-analysis. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 The treatment effects of acupuncture on postpartum depression differed when compared to different controls. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Unlike the efficacy of acupuncture on other depression diseases such as major depressive disorder and post-stoke depression or even depression related insomnia, the treatment efficacy of acupuncture on postpartum women was lower compared to other treatment methods. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Insomnia Depression Review
31016194 However, they suggested that combining acupuncture with psychotherapy would result in higher HADM, lower self-rating depression scale scores, and self-rating anxiety scale scores. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Anxiety Depression Review
31016194 Though our meta-analysis revealed that acupuncture had a lower efficacy compared to other antidepression treatments, symptoms of depression relief were observed in the majority of the studies analysed. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 These findings indicate that although the efficacy of acupuncture was lower compared to antidepressants, the benefits of acupuncture were still attractive to women with postpartum depression due to their negligible side-effects. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Side Effects Depression Review
31016194 Large-scale and well-designed RCTs are required before a conclusive statement could be made regarding the efficacy of acupuncture for the treatment of postpartum depression. Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Forest plot displaying the overall effect of acupuncture versus controls in the Hamilton Rating Scale for Depression (HAMD). Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31016194 Forest plot displaying the overall effect of acupuncture versus controls in Edinburgh Postnatal Depression Scale (EPDS). Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. Depression Review
31223326 Studies were included if they (1) focused on a kind of NTCT (e.g., acupuncture, acupressure, auricular therapy, massage, Qigong, moxibustion, and Tai Chi); (2) involved patients diagnosed as MDD based on any valid and clinical diagnostic criteria; (3) recruited adults (aged above 18); (4) had a control group; (5) targeted outcomes using depression scales with at least one neuroscience measurement including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and functional near-infrared spectroscopy (fNIRS) but were not limited to biomarkers such as blood, saliva, and urine samples; (6) were full papers written in English or Chinese; and (7) were published in peer-reviewed journals. Evid Based Complement Alternat Med. 2019 May 15;2019:2183403. doi: 10.1155/2019/2183403. eCollection 2019. Depression Review
31223326 A significant improvement was found in reducing depressive symptoms (SMD -0.69, 95% CI -1.09 to -0.28, p=0.002, I2 = 73%, p< 0.0008; Figure 3) with the measurement of depression scales compared to the medication group over time after the acupuncture-medication intervention. Evid Based Complement Alternat Med. 2019 May 15;2019:2183403. doi: 10.1155/2019/2183403. eCollection 2019. Depression Review
31223326 There are three plausible pathological mechanisms that may explain how the body responds to acupuncture interventions in patients with depression. Evid Based Complement Alternat Med. 2019 May 15;2019:2183403. doi: 10.1155/2019/2183403. eCollection 2019. Depression Review
31223326 Available evidence suggests that there will be a drop in the level of cortisol in patients with depression after acupuncture intervention. Evid Based Complement Alternat Med. 2019 May 15;2019:2183403. doi: 10.1155/2019/2183403. eCollection 2019. Depression Review
31223326 Although neuroimaging studies show some beneficial effects in patients with depression after acupuncture interventions, valid conclusion cannot be drawn at this stage due to the small number of available studies. Evid Based Complement Alternat Med. 2019 May 15;2019:2183403. doi: 10.1155/2019/2183403. eCollection 2019. Depression Review
31304087 Overview of systematic reviews with meta-analyses on acupuncture in post-stroke cognitive impairment and depression management Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Acupuncture has been using as an alternative non-pharmacological therapy in the management of post stroke depression and cognitive impairment but its effectiveness and safety remain controversial. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Systematic reviews summarized the treatment effects of acupuncture for post stroke cognitive impairment and post stroke depression were considered eligible. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Furthermore, acupuncture versus antidepressant demonstrated statistically significant improve depression measured by increasing in 17-item Hamilton Depression Rating Scale in comparing to cognitive rehabilitation after 2 weeks treatment (Pooled WMD= -2.34, 95% CI= -3.46 to -1.22, I2 = 5%). Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Many clinical studies have suggested the use of acupuncture in the management of post stroke depression and cognitive impairment. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 The treatment effects of acupuncture on post-stroke cognitive impairment and depression were inconclusive from systematic reviews. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Systematic reviews have been conducted to examine the potential relative benefits or harms of acupuncture in the treatment of post-stroke cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 However, the treatment benefits of acupuncture on post-stroke cognitive impairment and depression are still unclear due to the differences of methods, and quality of systematic reviews. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Furthermore, there has been no overview of systematic reviews to analyze the effectiveness and safety of acupuncture for improving cognitive function and depression in post-stroke patient. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Cognitive Function Depression Review
31304087 In this overview of systematic reviews, we aim to summarize the best available clinical evidence on the effectiveness and safety of acupuncture on post-stroke cognitive impairment and depression management. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 This study will provide a comprehensive synthesis of clinical evidence on acupuncture on post-stroke cognitive impairment and depression receiving routine stroke care, which may help in identifying treatment alternatives with acupuncture on post-stroke cognitive impairment and depression management so as to provide a basis to develop an integrative medicine model for post-stroke cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 We evaluated all possible clinical evidence in the use of acupuncture versus conventional intervention for post-stroke cognitive impairment management and the use of acupuncture versus anti-depressant for post stroke depression treatment. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 For the treatment of post stroke depression, two types of comparisons were considered to be included in this overview of SRs: (1) acupuncture versus anti-depressant only; and (2) acupuncture versus placebo of acupuncture plus anti-depressant. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 We evaluated all possible clinical evidence in the use of acupuncture along with conventional medicine intervention for post-stroke cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Flowchart of literature selection on meta-analyses of acupuncture in post-stroke cognitive impairment and depression management. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Ten SRs evaluated the evidence of acupuncture for improvement of depression in post-stroke patient versus antidepressants. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 One SR showed acupuncture versus antidepressants demonstrated statistically significant improve depression measured by increase in HAMD 17 items in compared to cognitive rehabilitation after 2 weeks treatment with low heterogeneity (Pooled WMD = −2.34, 95% CI = −3.46 to −1.22, 4 RCTs, I2 = 5%). Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Three SRs reviewed acupuncture or Electro-acupuncture versus antidepressants for improvement of depression measure by HAMD (24 items) reduction rate. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 To the best of our knowledge, this review is the first overview of systematic reviews to explore the efficacy and safety of acupuncture for the management of cognitive impairment and depression after stroke. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Furthermore, acupuncture can be more effective and safe than antidepressants in the treatment of post stroke depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Our main aim in this study was to address the research evidence on acupuncture in post-stroke cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 The major practical contribution of our research is that it provides evidence for clinicians and policy makers to identify treatment alternatives with acupuncture in managing post-stroke cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 A second important implication of our study derives from our finding on the depression management by acupuncture. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Acupuncture is potentially effective and safe monotherapy for post stroke depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 However, none of the included SRs studied the treatment benefits of acupuncture in post-stroke patients with both cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Researcher should explore the potential treatment benefits in acupuncture for post-stroke patients with both cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 The treatment benefits of acupuncture in post-stroke cognitive impairment and depression cannot be concluded in long-term treatment. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Search strategies and results for overview review on systematic review with meta-analysis on acupuncture in the treatment of cognitive impairment and post stroke depression management all appendix. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Acupuncture in the treatment of cognitive impairment and depression after stroke: Overview of Meta-Analyses Results (Other reported outcomes) Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Protocol Title: Overview of systematic reviews with meta-analyses on acupuncture in post-stroke cognitive impairment and depression management Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 Systematic reviews (SRs) with meta-analysis have also been conducted to examine the relative benefits or harms of acupuncture together with conventional medicine intervention in the treatment of cognitive impairment and depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31304087 This is an overview of the effectiveness and safety of acupuncture for post-stroke cognitive impairment and post stroke depression. Integr Med Res. 2019 Sep;8(3):145-159. doi: 10.1016/j.imr.2019.05.001. Epub 2019 May 15. Depression Review
31370200 Acupuncture for Depression: A Systematic Review and Meta-Analysis J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Patients with depression are common users of complementary therapies, such as acupuncture, either as a replacement for, or adjunct to, their conventional treatments. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Acupuncture showed clinically significant reductions in the severity of depression compared to usual care (Hedges (g) = 0.41, 95% confidence interval (CI) 0.18 to 0.63), sham acupuncture (g = 0.55, 95% CI 0.31 to 0.79), and as an adjunct to anti-depressant medication (g = 0.84, 95% CI 0.61 to 1.07). J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 A significant correlation between an increase in the number of acupuncture treatments delivered and reduction in the severity of depression (p = 0.015) was found. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Our recent Cochrane review on acupuncture for the treatment of depression showed some evidence of benefits but did not explore the contribution of different dose components on the clinical outcomes for depression, for example, the number and frequency of acupuncture sessions provided. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 There was evidence of a moderate benefit in the severity of depression in the acupuncture group compared to usual care g = 0.41 (N = 1, n = 301, 95% CI 0.18 to 0.63). J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 The pooled effect of acupuncture on the severity of depression compared to sham at the end of the intervention (Figure 3) was moderate g = 0.55 (N = 12, n = 646, 95% CI 0.31 to 0.79, Q = 38.15, p < 0.001, I2 = 71.2). J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 The pooled effect of acupuncture plus SSRI/SNRI medication on the severity of depression at the end of intervention compared to SSRI/SNRI medication alone (Figure 4) was large g = 0.84 (N = 18, n = 1169, 95% CI 0.61 to 1.07, Q = 87, I2 = 80.5). J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 There was no difference in the reduction in severity of depression when comparing fixed, semi-standardised, and individualised acupuncture sub-groups (p = 0.468), or when comparing different needle retention times (p = 0.796). J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 There was no significant association between the number of acupuncture points and the reduction in the severity of depression (N = 29, n = 2268, B = 0.055, SE = 0.079, Z = 0.70, p = 0.48). J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 In this review we identified 29 studies of acupuncture for depression, and these studies included 2268 participants. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Acupuncture was found to be associated with clinically relevant effect sizes in reducing the severity of depression when compared to usual care alone, to sham acupuncture, and to SSRI/SNRI medication alone. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 This was by far the largest trial, with 755 patients, and the only one to address the practical question of what impact acupuncture might have on patients with depression in primary care, who are routinely referred to acupuncturists. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Compared to the most recent Cochrane review of acupuncture for depression, within which databases were searched only up to June 2016, the present review differs in several important aspects. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 This review includes studies published until December 2018, increases clinical relevance by including only patients with depression as the primary presentation, includes a quality assessment measure for the acupuncture delivered in the form of the NICMAN scale, and explores the contribution of various dosage components on depression related clinical outcomes. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 In terms of the implications for research, the stand-out requirement is for more higher-quality randomised control trials to evaluate the effectiveness of acupuncture for treatment for depression. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 The results of these trials will provide important evidence for patients when considering the option of acupuncture, for clinicians when considering the referral of their patients to an acupuncturist, for decision-makers when considering providing resources to fund mental health treatments, and for policy-makers when considering questions of health policy related to depression. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 In terms of implications for clinical practice, the findings of this review provide some limited support for acupuncture as a treatment for depression. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Most patients with depression will be offered SSRI or SNRI anti-depressants as a first line treatment, and our evidence shows a moderate effect size is associated with acupuncture provided for this patient group. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 There remain further unanswered questions regarding which patients might find acupuncture most beneficial, in terms of severity of depression, whether on anti-depressants or not, and the implications of comorbidity. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Acupuncture showed clinically-relevant benefits in reducing the severity of depression at the end of treatment compared to sham acupuncture, usual care, and as an adjunct treatment to anti-depressant medication. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Acupuncture versus sham control on the severity of depression. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 Acupuncture plus SSRI/SNRI versus SSRI/SNRI alone on the severity of depression. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31370200 The effect of acupuncture on the severity of depression by study location. J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. Depression Review
31374032 There is a clinical basis for ear acupuncture, which may be effective for immediate pain relief, as well as psychiatric conditions such as substance abuse, insomnia, depression, and anxiety. Medicine (Baltimore). 2019 Aug;98(31):e16631. doi: 10.1097/MD.0000000000016631. Pain Relief Insomnia Anxiety Depression Review
31379957 We electronically searched the databases, including PubMed, MEDLINE, clinical Key, the Cochrane Library, and the China National Knowledge Infrastructure from their inception to December 2018 using the following MeSH headings and keywords alone or in varied combination: acupuncture, molecular, signal transduction, genetic, cerebral ischemic injury, cerebral hemorrhagic injury, stroke, epilepsy, seizure, depression, Alzheimer's disease, dementia, vascular dementia, and Parkinson's disease. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31379957 We electronically searched the databases, including PubMed, MEDLINE, clinical Key, the Cochrane Library, and the China National Knowledge Infrastructure from their inception to December 2018 using the following MeSH headings and keywords alone or in varied combination: acupuncture, molecular, signal transduction, genetic, cerebral ischemic injury, cerebral hemorrhagic injury, stroke, epilepsy, seizure, depression, Alzheimer's disease (AD), dementia, vascular dementia (VD), and Parkinson's disease (PD). Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31379957 In addition to medication and psychosocial support, acupuncture serves as an alternative option for patients with depression that exhibits promising effects and fewer side effects. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Side Effects Depression Review
31379957 demonstrated that acupuncture on LI4 and LR3 regulated the expression of soluble N-ethylmaleimide-sensitive factor attachment receptor protein, a fusion mediator, and promoted depression remission. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31379957 Acupuncture regulates the NO-cGMP pathway by increasing nNOS and cGMP levels, which contribute to its effect on depression relief. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31379957 demonstrated that acupuncture on GV20 and PC6 inhibited the proinflammatory pathway of depression by reducing NF-κB protein and COX-2 levels. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31379957 Molecular studies have reported that acupuncture plays a role in the neuroendocrine model of depression. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31379957 demonstrated that acupuncture could relieve the symptoms of depression and increase cortisol, PKA, and PKC levels. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31379957 The results of the Gene Ontology functional term and Kyoto Encyclopedia of Genes and Genomes database analysis indicated that the regulation of the Toll-like receptor signaling pathway, nucleotide-binding oligomerization domain-like receptor signaling pathway, MAPK/ERK pathway, PI3K/Akt pathway, neurotrophin signaling pathway, TNF pathway, and NF-κB pathway is the mechanism through which acupuncture treats depression. Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. Depression Review
31438914 As one of complementary treatment modalities, previous studies have shown that acupuncture has hypnotic effects, especially in primary insomnia, depression-related insomnia, and cancer-related insomnia. BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. Insomnia Depression Review
31467579 Previous studies have shown that electroacupuncture treatment in inflammatory pain can be explained by two mechanisms of action: peripheral (endogenous opioid peptide, COX-2, serotonin, nerve growth factor, and bradykinin) and centric (spinal cord-related pathway, and central depression inhibitory system). Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. Depression Inflammatory Pain Review
31497504 A review done by the Department of Veterans Affairs in 2014 showed overview of the evidence base of acupuncture for mental health such as depression, schizophrenia, anxiety, posttraumatic stress disorder (PTSD), addiction, and chronic fatigue syndrome. Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. Anxiety Depression Review
31702639 We use Insomnia Severity Index (ISI) as the main outcome of insomnia and Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale(HAMD) and Self-Rating Anxiety Scale (SAS) as secondary indicators to evaluate the efficacy and safety of acupuncture treatment of insomnia, we will use Revman v.5.3 software to calculate data synthesis, and if the results are appropriate, meta-analysis can also be carried out. Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. Insomnia Anxiety Depression Sleep Quality Review
31802723 The outcome of depression was measured in two studies, both of which reported significant improvement in depression scores after the acupuncture or acupressure intervention. West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. Depression Review
31802723 Fifteen studies were included in the final review and findings tended to be in support of acupuncture and acupressure for symptoms such as agitation, anxiety, ADL function, sleep, mood, depression, and neuropsychological disturbances. West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. Anxiety Depression Mood Review
32038351 Results demonstrated that overall, massage therapy, tai-chi, dance/movement therapy, functional relaxation, reflexology, acupuncture and emotional freedom technique seem to alleviate stress, depression, anxiety, bipolar disorder and facilitate pain reduction. Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. Anxiety Depression Mood Review
32038351 Regarding psychopathology, acupuncture has demonstrated promising results for alleviating depression, bipolar disorder and mood associated with premenstrual disorder. Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. Depression Mood Review
32038351 Two meta-analyses demonstrated that acupuncture effectively treats major depressive disorder (MDD) and post-stroke depression (PSD) and should be considered an alternative treatment to antidepressants. Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. Depression Review
32051687 Effectiveness and Safety of Acupuncture for Perimenopausal Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 To determine the effectiveness and safety of acupuncture for perimenopausal depression. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 We searched the Cochrane Central Register of Controlled Trials, PubMed, EMBASE, CNKI, VIP Citation Databases, Wan Fang, and online trial registries such as ClinicalTrials.gov for randomized controlled trials (RCTs) assessing the efficacy and safety of acupuncture for perimenopausal depression. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Acupuncture for perimenopausal depression is safe and effective. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 We recommend acupuncture as a clinical treatment of perimenopausal depression. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 It has been reported that depression ranks second in the top 10 indications for acupuncture. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Moreover, multiple studies and clinical trials have documented the effectiveness of acupuncture in the treatment of depression. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Recent reports from randomized controlled trials (RCTs) on acupuncture indicate that the use of acupuncture in the management of for perimenopausal depression has also risen gradually risen. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 In this study, we carried out a systematic review of published RCTs on the use of acupuncture in the management of perimenopausal depression, aiming to better understand its benefits in the management of this condition relative to conventional treatment options. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 In this study, we included all RCTs on the use of acupuncture in the management of perimenopausal depression, whether the trials were blinded or not. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Our meta-analysis indicated that participants with perimenopausal depression benefited from both acupuncture and drugs. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Our analysis of both the effective rate and HAMD score revealed that acupuncture achieved better outcomes in the management of perimenopausal depression-relative antidepressants and HRT. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Additionally, follow-up analysis indicates that the benefits of acupuncture against perimenopausal depression last longer those of antidepressants. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Our meta-analysis suggests that, in the management of perimenopausal depression, acupuncture is relatively safer than pharmacological agents. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 In order to limit our analysis to the use of body acupuncture in the management of perimenopausal depression, we limited the intervention in the experimental group to manual acupuncture and electroacupuncture only and excluded the studies on ear acupuncture, moxibustion, or pharmacologic interventions. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Our analysis indicates that the use of acupuncture in the management of perimenopausal depression is safe, effective, and offers long-lasting benefits relative to antidepressants and HRT. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Our data indicate that acupuncture is an effective option for the clinical management of perimenopausal depression. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32051687 Because the existing studies are not of sufficiently high quality, higher quality RCTs are required to establish the clinical benefits and long-term effectiveness of acupuncture in the treatment of perimenopausal depression. Evid Based Complement Alternat Med. 2020 Jan 19;2020:5865697. doi: 10.1155/2020/5865697. eCollection 2020. Depression Review
32080154 There is also some clinical evidence of the effectiveness of ear acupuncture in psychiatric conditions such as substance abuse, insomnia, depression, and anxiety as well as immediate pain relief. Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. Pain Relief Insomnia Anxiety Depression Review
32080154 Among the diagnosed PTSD patients after disaster, compared to baseline, ear acupuncture improved the overall PTSD symptoms assessed by CAPS or PCL-M, and also improved depression and anxiety as assessed by HAMD and HAMA, respectively. Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. Anxiety Depression Review
32195928 Effectiveness and safety of acupuncture in post-stroke depression (PSD) Medicine (Baltimore). 2020 Mar;99(12):e18969. doi: 10.1097/MD.0000000000018969. Depression Review
32195928 The effectiveness of acupuncture combined with antidepressant medication on depression has been proved in a systematic review. Medicine (Baltimore). 2020 Mar;99(12):e18969. doi: 10.1097/MD.0000000000018969. Depression Review
32195928 We hope to find out the better form of acupuncture that helps improving depression. Medicine (Baltimore). 2020 Mar;99(12):e18969. doi: 10.1097/MD.0000000000018969. Depression Review
32476804 Three studies assessed the anxiety and depression degrees by different questionnaires and showed improvement in mental status after acupuncture treatment (see Table 3). World J Gastroenterol. 2020 May 21;26(19):2440-2457. doi: 10.3748/wjg.v26.i19.2440. Anxiety Depression Review
32714417 Effect of Acupuncture on Chronic Pain with Depression: A Systematic Review Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 Acupuncture, a unique therapeutic method of traditional Chinese medicine, has been reported to potentially serve as an alternative treatment for patients with comorbid chronic pain and depression by many research studies. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 In the treatment of chronic pain with depression, acupuncture could not only get better clinical efficacy, but also have higher security compared with medicine therapy, which can be used in patients with poorer response to the conventional medication or suffering from serious side effects. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Side Effects Depression Review
32714417 Acupuncture uses needles to stimulate specified acupuncture points, which has the advantages of simple operation, economical cost and few side effects, and it has obvious curative effect on pain and depression separately. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Side Effects Depression Review
32714417 There are also many randomized controlled trials having confirmed that acupuncture can alleviate depression and improve patients' quality of life. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 As the optimized comorbid chronic pain and depression management is to allow progress in restoring function while reducing long-term reliance on medical therapy, acupuncture may potentially serve as an alternative treatment for patients with comorbid chronic pain and depression. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 To date, there have been several systematic reviews of acupuncture in the treatment for chronic pain or for depression. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 However, the effect of acupuncture as a treatment for chronic pain and depression comorbidity is questionable, and there is no systematic review of the use of acupuncture for comorbid chronic pain and depression, so the experts may confront problems to conduct further research in the related field. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 Therefore, a comprehensive systematic review of acupuncture in the treatment for chronic pain with depression is needed. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 A comprehensive search for studies about the effectiveness of acupuncture for chronic pain with depression was conducted through the online database. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 Patients in the experimental group were treated with acupuncture alone or in combination with other therapy, while those in the control group were subjected to other therapy without acupuncture for chronic pain with depression. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 In order to evaluate the independent effects of acupuncture, the following trials were excluded: (1) conference abstracts, review articles, animal studies, cadaveric studies, in vitro studies, or articles published in a form other than clinical trials; (2) any control group that included acupuncture therapies; (3) literatures without relevant indicators or quantitative data; (4) evaluation indicators include only chronic pain or only depression; (5) repeated published literature. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 This study is a comprehensive systematic review of acupuncture in the treatment for chronic pain with depression. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 There were significant differences in the VAS score and HAMD, decreasing between the two groups after treatment, indicating that acupuncture used alone or in combination with medication therapy can relieve pain and depression better than medication. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 The above results suggested that acupuncture has not only a better clinical result on the treatment of chronic pain with depression but also has a higher security compared with medication therapy. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 The results of the systematic review suggested that acupuncture has a promising application prospect due to its unique advantages for the treatment of chronic pain with depression, and it can be used in patients with poorer response to the medication or suffering from serious side effects. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Side Effects Depression Review
32714417 Previous systematic reviews of acupuncture for chronic pain and depression comorbidity are not available. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 Thus, more high-quality, rigorously designed, and well-controlled RCTs are still needed to support the clinical application of acupuncture for the treatment of chronic pain with depression. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 The design of future studies in this area can play an important role in improving the quality of evidence and address the lack of evidence to support acupuncture for the management of chronic pain and depression comorbidity. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
32714417 Acupuncture has a promising application prospect due to its unique advantages for the treatment of chronic pain with depression comorbidity, which can be used in patients suffering from some certain chronic pain with depression comorbidity with poorer response to the conventional medication or suffering from serious side effects. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Side Effects Depression Review
32714417 High-quality RCTs are needed to support the current clinical application of acupuncture for the treatment of chronic pain with depression comorbidity and to broaden the clinical application. Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. Depression Review
33005199 Acupuncture treatment (AT) has been widely used for poststroke rehabilitation, and many systematic review and meta-analysis studies have addressed the effects of acupuncture on poststroke complications such as shoulder pain, spasticity, depression, insomnia, and dysphagia. Evid Based Complement Alternat Med. 2020 Sep 14;2020:4981945. doi: 10.1155/2020/4981945. eCollection 2020. Insomnia Depression Review
33029119 Applications of Acupuncture Therapy in Modulating the Plasticity of Neurodegenerative Disease and Depression: Do MicroRNA and Neurotrophin BDNF Shed Light on the Underlying Mechanism? Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 In this short review, we present evidence of shared biological substrates among stroke, AD, PD, and depression and summarize the possible influencing mechanisms of acupuncture on the neuroplasticity of these diseases. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 We discuss neuroplasticity underscored by the roles of miRNAs and BDNF, which might further reveal the potential biological mechanism of neurodegenerative diseases and depression by acupuncture. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 Numerous previous studies have shown that acupuncture has positive clinical effects on stroke, AD, PD, and depression. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 We reviewed recent publications related to acupuncture on related miRNAs and BDNF in neurodegenerative diseases and depression. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 Acupuncture Plays a Therapeutic Role in Depression by Regulating the Expression of BDNF and miRNAs Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 Acupuncture therapy has been shown not only to be an effective treatment modality for depression but also to improve depression-like behaviours and reverse the impairment of LTP. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 Compared with preacupuncture treatment conditions, depression-like behaviours were ameliorated and induced an increase in BDNF expression in the hippocampus after treatment. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 In addition, in maternally separated depression rat pups, acupuncture stimulation at HT7 significantly increased the BDNF level of the prefrontal cortex. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 In summary, acupuncture-promoted plasticity protein BDNF expression seems to play an important role in the development of depression. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 However, further studies are required to investigate the effects of acupuncture on miRNA expression in depression, as acupuncture could target BDNF and related plasticity mechanisms. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 Therefore, acupuncture promoted synaptic plasticity via BDNF protein expression and regulated a few miRNAs that were found to target BDNF, which seem to play important roles in the development of depression. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 Based on the current analysis of the published literature, we summarize that acupuncture treatment seemingly restores the level of BDNF, which is thought to play significant roles in depression and neurodegenerative diseases such as AD, stroke, and PD. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33029119 New findings could lead to the discovery of the biological mechanism by which acupuncture regulates the miRNA-BDNF network and could identify the underlying neurodegenerative disease-depression comorbidity mechanism of acupuncture treatment in the near future. Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. Depression Review
33327222 Regarding nausea and vomiting, we found that acupuncture was associated with a statistically significant increase appetite and reduce the level of fatigue, anxiety, and depression. Medicine (Baltimore). 2020 Dec 11;99(50):e21820. doi: 10.1097/MD.0000000000021820. Nausea and Vomiting Anxiety Depression Review
33408601 Mounting evidence supports that acupuncture provides satisfactory effects for various neuropsychiatric disorders including vascular dementia (Yu et al.,; Xiao et al.,), depression (Wang et al.,), and insomnia (Yin et al.,). Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. Insomnia Depression Review
33436036 The mechanism of electroacupuncture for depression on basic research: a systematic review Chin Med. 2021 Jan 13;16(1):10. doi: 10.1186/s13020-020-00421-y. Depression Review
33436036 Electroacupuncture (EA) is generally accepted as a safe and harmless treatment option for alleviating depression. Chin Med. 2021 Jan 13;16(1):10. doi: 10.1186/s13020-020-00421-y. Depression Review
33436036 Electronic searches of PubMed, WOS, the CNKI, Wanfang and the VIP database were conducted using the following search terms: (depression OR depressive disorder OR antidepressive), (rat OR mouse) AND (acupuncture OR EA). Chin Med. 2021 Jan 13;16(1):10. doi: 10.1186/s13020-020-00421-y. Depression Review
33436036 Our findings also explain why acupuncture can treat various disorders in addition to depression. Chin Med. 2021 Jan 13;16(1):10. doi: 10.1186/s13020-020-00421-y. Depression Review
33436036 We searched the PubMed, Web of Science (WOS), the China National Knowledge Infrastructure (CNKI), Wanfang Data Information Site and the VIP information database using the terms depression OR depressive disorder OR antidepressive AND rat OR mouse AND acupuncture OR EA. Chin Med. 2021 Jan 13;16(1):10. doi: 10.1186/s13020-020-00421-y. Depression Review
33441387 The impact of acupuncture on cancer pain in palliative care was sparsely addressed in reviews of acupuncture on pain improvement, though reviews have included other symptoms such as fatigue, nausea, depression, chemotherapy-induced or radiotherapy-induced side effects for palliative care in patients with cancer. BMJ Support Palliat Care. 2021 Sep;11(3):264-270. doi: 10.1136/bmjspcare-2020-002638. Epub 2021 Jan 13. Cancer Pain Side Effects Nausea and Vomiting Depression Review
33584181 We used the search string [pain(MeSH)] OR [headache(MeSH)] OR [osteoarthritis(MeSH)] OR [fibromyalgia(MeSH)] OR [cancer (MeSH)], AND [acupuncture(MeSH)], AND [psychological disorder(MeSH)], OR [mental disorder(MeSH)] OR [emotional (MeSH)], OR [anxiety(MeSH)], OR [depression(MeSH)] for PubMed and adapted it for Web of Science and Embase. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Mood Review
33584181 The majority of the studies suggest that acupuncture can significantly improve the emotional symptoms (such as anxiety and depression) in patients with chronic pain compared with both usual care and waiting list. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Mood Review
33584181 At the end of the treatment, compared with the waiting-list group, participants receiving acupuncture fared significantly better for the headache days and depression (measured with Allgemeine Depressionsskala). Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 However, the depression level (measured with the Beck Depression Inventory scores) did not improve significantly after acupuncture treatment. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 However, for days with migraine and Allgemeine Depressionsskala, there was no significant difference between the acupuncture and metoprolol groups (P > 0.05). Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 In addition, the depression level (measured with the Allgemeine Depressionsskala depression scale) did not improve significantly after acupuncture treatment. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 After treatment, compared with the sham acupuncture group, electroacupuncture significantly improved the pain threshold in the neck and shoulder regions, anxiety, depression, and satisfaction with life (P < 0.05). Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 It reported improved pain intensity (measured with Visual Analog Scale) and psychological stress (measured with Hospital Anxiety and Depression Scale) in the acupuncture group (acupuncture vs. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 In addition, depression level (measured with Beck Depression Inventory) of the acupuncture group was improved during the entire study (P < 0.01), but no significant effect was observed between the groups. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 However, acupuncture did not reduce the depression (measured with Allgemeine Depressionsskala) of patients compared with neither waiting-list nor sham acupuncture. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 An RCT comparing acupuncture (one sessions per week for 6 weeks, each session lasted 20 min) with physiotherapy and standardized advice in 181 patients with severe osteoarthritic knee pain awaiting knee arthroplasty found no significant changes in knee pain (measured with the pain subscale of Western Ontario and McMaster Universities Osteoarthritis Index), anxiety, and depression (measured with Hospital Anxiety and Depression Scale) among the three groups. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 On the basis of several studies highlighted in this section, acupuncture may improve psychological symptoms caused by chronic cancer pain including tension, anxiety, and depression. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Cancer Pain Anxiety Depression Review
33584181 It found that acupuncture showed a significant reduction in numbness/tingling, anxiety, depression, and other psychological disorders (measured with Edmonton Symptom Assessment Scale) at the end of the treatment (P < 0.001). Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33584181 Acupuncture applied to chronic cancer pain conditions is also typically beneficial with respect to anxiety and depression. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Cancer Pain Anxiety Depression Review
33584181 It has been proven that 5-HT in the dorsal raphe nucleus of pain-related depression condition was increased through acupuncture. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 A study in reserpine-induced pain-depression dyad rat model showed that electroacupuncture of 100 Hz alleviated the pain-depression dyad and upregulated 5-HT in the dorsal raphe nucleus of reserpine-injected rats. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Depression Review
33584181 A study in patients with chronic pain and serious psychiatric difficulties indicated that acupuncture treatment was associated with significant improvement in both pain and depression, and the degree of symptom relief was correlated with the degree of post-acupuncture increase in plasma met-enkephalin immunoreactivity. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Immunity Depression Review
33584181 Acupuncture may mediate its anti-pain, anti-anxiety, anti-depression, and other therapeutic effects via regulating brain regions and their related substances. Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. Anxiety Depression Review
33680223 Acupuncture for Chronic Pain-Related Depression: A Systematic Review and Meta-Analysis Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Review
33680223 The aim of this systematic review was to summarize and evaluate the existing evidence on the effectiveness and safety of acupuncture in relieving chronic pain-related depression (CPRD). Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Review
33680223 Therefore, acupuncture has a satisfactory therapeutic effect on diseases involving neuroendocrine pathological changes (such as chronic pain, menopause, depression, and insomnia), with a very rare occurrence of adverse events. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Insomnia Depression Review
33680223 Although the benefits of acupuncture treatment of CP and depression have been widely reported, a recent meta-analysis on acupuncture for chronic pain with depression found that acupuncture is efficient and safe therapy. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Review
33680223 The keywords used for the search consist of three parts: chronic pain (e.g., musculoskeletal pain, back pain), depression (e.g., depression, affective disorder, affective symptoms, mood), and acupuncture (e.g., acupuncture, electroacupuncture needling, acupoint). Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Mood Review
33680223 RCTs were published in English or Chinese; (2) types of participants: Participants met the diagnosis of depression and chronic pain at the same time; (3) type of intervention: The only experimental treatments allowed are manual acupuncture or electroacupuncture alone, or either of these combined with the control group (drugs); (4) types of control groups: The control group should be conventional drug therapy, and the method, dosage, and course of treatment were reported in detail. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Review
33680223 At present, acupuncture has been widely used in the clinical treatment of various diseases in many countries around the world, among which chronic pain and depression are common diseases treated by acupuncture. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Review
33680223 Modern research has shown that acupuncture analgesia is related to the interaction of a variety of biologically active molecules in the pain process, including neurotransmitters, inflammatory mediators, cell signaling molecules and neuropeptides, etc.. At the same time, relevant depression research also affirmed the antidepressant effects of acupuncture. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Review
33680223 Therefore, acupuncture can effectively relieve depression symptoms. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Depression Review
33680223 The results of our current systematic review and meta-analysis show that compared with drug treatment, single acupuncture treatment has the same effect in reducing pain and relieving symptoms of depression in patients with CPRD, but the incidence of adverse reactions of acupuncture treatment is smaller. Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. Adverse Reactions Depression Review
33794857 Acupuncture for post-stroke depression: a systematic review and meta-analysis BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 Acupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 In addition, more recent trials about acupuncture for PSD have been published and add to the evidence of the association between acupuncture and the degree of depression. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 A trial conducted in 2018 revealed that patients with moderate or severe depression who received a combination of acupuncture and medication experienced visible depression relief. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 This nonblinded review of trials highlights that the combination of acupuncture and conventional treatment had a significant effect on HAM-D scores compared with conventional treatment, and the result was consistent regardless of the degree of depression, which is consistent with findings in previous studies and reviews and helps to increase confidence in our findings. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 In our study, acupuncture combined with conventional treatments compared with conventional treatments for PSD was the most effective when depression was measured using the HAM-D24 scale, followed by the HAM-D17 scale, finally, the HAM-D scale. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 There exists a weak relationship between the HAM-D scale version used to evaluate the effect of acupuncture on depression and the strength of the association, yet this relationship depended on the intervention used. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 In addition, some researchers have proposed that the Post-Stroke Depression Scale (PSDS) is a valid, reliable and specific tool to evaluate PSD, and some hold that the HAM-D6 could be a new indicator to evaluate the effect of acupuncture on PSD because it aims to investigate the discrimination between active treatment and placebo. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33794857 Second, this review indicated that acupuncture for PSD can largely reduce the degree of depression, but we did not find a suitable clinically important difference (MCID) for the HAM-D, which limits our ability to determine the clinical effectiveness. BMC Complement Med Ther. 2021 Apr 1;21(1):109. doi: 10.1186/s12906-021-03277-3. Depression Review
33883931 For instance, in a rat model of depression, acupuncture treatment significantly up-regulates mRNA and protein expressions of brain-derived neurotrophic factor (BDNF) in the frontal cortex and hippocampus of rats which contributes greatly to the antidepressant action of acupuncture. J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. Depression Review
33883931 Acupuncture is widely considered to be a potential effective therapy in treatment of depression and anxiety but has been involved in very limited studies concerning emotional disorders during PIPN, so further exploration is called for. J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. Anxiety Depression Mood Review
33896475 A systematic review of 24 studies of acupuncture for symptom reduction in patients with advanced and end-stage CKD found low quality evidence that adjuvant manual acupressure is more effective than routine care in improving depression, fatigue, and sleep quality. Semin Nephrol. 2021 Jan;41(1):68-81. doi: 10.1016/j.semnephrol.2021.02.007. Depression Sleep Quality Review
33917977 The use of acupuncture has been investigated not only in various pain conditions but also in psychiatric problems such as depression, insomnia, and anxiety disorders. J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Insomnia Anxiety Depression Review
33917977 In these studies, the effects and/or underlying mechanisms of acupuncture on anxiety and fear behaviors, depression behavior, sleep disturbance, cognitive symptoms (especially spatial learning and memory), and stress responses in PTSD animal models have been reported (Figure 3 and Table 2). J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. Insomnia Stress Response Learning and Memory Ability Anxiety Depression Review
33936242 explored the clinical effect of body acupuncture combined with ear acupuncture in the treatment of kidney deficiency and liver depression POF; the total effective rate in the treatment group was 80%, which was superior to 66.67% in the control group. Evid Based Complement Alternat Med. 2021 Apr 15;2021:6677767. doi: 10.1155/2021/6677767. eCollection 2021. Depression Kidney Review
33936242 treated 60 patients with POF of kidney deficiency and liver depression type by electroacupuncture combined with heat sensitive moxibustion, with a total effective rate of 93.3%. Evid Based Complement Alternat Med. 2021 Apr 15;2021:6677767. doi: 10.1155/2021/6677767. eCollection 2021. Depression Kidney Review
34087835 Comparison between acupuncture and antidepressant therapy for the treatment of poststroke depression Medicine (Baltimore). 2021 Jun 4;100(22):e25950. doi: 10.1097/MD.0000000000025950. Depression Review
34087835 In this paper, a systematic review and meta-analysis of published randomized controlled trials (RCTs) was conducted to compare the efficacies of acupuncture and antidepressant therapy for the treatment of poststroke depression (PSD). Medicine (Baltimore). 2021 Jun 4;100(22):e25950. doi: 10.1097/MD.0000000000025950. Depression Review
34087835 The following MeSH terms were used: stroke, depression, acupuncture, zhenci, zhenjiu and zhenfa. Medicine (Baltimore). 2021 Jun 4;100(22):e25950. doi: 10.1097/MD.0000000000025950. Depression Review
34087835 Extracted data included study design, sample size, intervention, diagnostic criteria of PSD, baseline Hamilton Depression Rating Scale (HAMD) score, publication period, treatment duration, number of acupuncture sessions, study country, HAMD score following treatment, total clinical efficacy, National Institute of Health Stroke Scale (NIHSS) score, and Treatment Emergent Symptom Scale (TESS) score. Medicine (Baltimore). 2021 Jun 4;100(22):e25950. doi: 10.1097/MD.0000000000025950. Depression Review
34087835 (A) Forest plot representing acupuncture therapy vs antidepressants for PSD: Clinical totally efficiency of depression after treatment; (B) A funnel plot identifying a paper with no significant publication bias in the assessment of clinical totally efficiency after treatment. Medicine (Baltimore). 2021 Jun 4;100(22):e25950. doi: 10.1097/MD.0000000000025950. Depression Review
34087835 Results suggest that acupuncture plays an important role in both depression and stroke at the same time. Medicine (Baltimore). 2021 Jun 4;100(22):e25950. doi: 10.1097/MD.0000000000025950. Depression Review
34122180 Acupuncture as an Independent or Adjuvant Management to Standard Care for Perimenopausal Depression: A Systematic Review and Meta-Analysis Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. Depression Review
34122180 Background: Many women with perimenopausal depression (PMD) have sought alternative therapies such as acupuncture because of concerns about risks associated with antidepressant and hormone replacement therapy (HRT). Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. Depression Review
34122180 Meta-analyses indicated that acupuncture significantly reduced the global scores of Hamilton Depression Scale (HAMD) [standardized mean difference (SMD) = −0.54, 95% CI (−0.91, −0.16), p < 0.01], compared with standard care. Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. Depression Review
34122180 Not enough data were reported on whether acupuncture also has intermediate- and long-term effects on perimenopausal symptoms other than depression in women with PMD. Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. Depression Review
34122180 Future research should include effective sample size calculation, appropriate sham acupuncture control, which is near non-acupoints or acupoints unrelated to depression/menopausal symptoms with shallow needling and without De-qi sensation, an ITT analysis for outcomes, and more comprehensive follow-ups. Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. Depression Review
34122180 Future studies need to include appropriate sham/placebo acupuncture and patient-assessor blinding methods in the trial designs, clarify whether acupuncture could also be an adjuvant to HRT, observe the intermediate- and long-term effects of acupuncture on perimenopausal symptoms other than depression in women with PMD, and understand if the improvement is associated with reproductive hormone changes induced by acupuncture. Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. Depression Review
34178633 Moreover, patients treated with acupuncture were more likely to experience improvements in hot flashes scores, fatigue, sleep disturbance, and anxiety compared to those in the control group, while the improvements in depression were comparable across both groups. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Insomnia Anxiety Depression Review
34178633 The Society for Integrative Oncology (SIO) clinical practice guidelines on the evidence-based use of integrative therapies during and after BC treatment recommended that acupuncture could be considered for anxiety, depression, fatigue, pain, hot flashes and QoL, but the use of acupuncture should be based on professional judgment and patient preferences due to the fact that the net benefit is small. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 Forest plot of the change of anxiety and depression in BC patients treated with acupuncture and control from the bassline to end of treatment. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 noticed similar changes in the severity of depression and anxiety between the acupuncture and control groups from the pre- to post-treatment period. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 drew the conclusion that acupuncture improved anxiety and depression using the HADS. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34178633 This review pointed out that the use of acupuncture might improve the QoL, pain, hot flashes, fatigue, sleep disturbance and anxiety of BC patients compared with the use of control management strategies, while the difference in depression was not statistically significant between the two groups at EOT. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Insomnia Anxiety Depression Review
34178633 Relatively few studies had explored the effects of acupuncture for anxiety or depression in patients with cancer, and these syndromes were commonly used as secondary outcome measures in studies. Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. Anxiety Depression Review
34276340 Based on syndrome differentiation, clinicians may also prefer to use acupuncture combined with herbal decoction to treat PD-related depression. Front Aging Neurosci. 2021 Jul 1;13:676827. doi: 10.3389/fnagi.2021.676827. eCollection 2021. Depression Review
34276340 Acupuncture-related therapy has been studied fairly advanced in improving fatigue, sleepiness, depression, constipation, and cognitive decline; and the effect is positive. Front Aging Neurosci. 2021 Jul 1;13:676827. doi: 10.3389/fnagi.2021.676827. eCollection 2021. Depression Review
34281592 For instance, acupuncture and moxibustion reduced the plasma levels of CORT and ACTH in parturient isolated rats and in a rat model of depression. Chin Med. 2021 Jul 19;16(1):56. doi: 10.1186/s13020-021-00466-7. Depression Review
34307076 Acupuncture points are usually found physically in areas of surface depressions and physiologically in cutaneous regions typified by low electrical impedance and high electrical conductivity. Open Vet J. 2021 Apr-Jun;11(2):203-209. doi: 10.5455/OVJ.2021.v11.i2.3. Epub 2021 Apr 15. Depression Review
34336626 After acupuncture was introduced to places outside of China and started to gain popularity, many studies have been conducted to determine if there is a benefit in the use of acupuncture in things such as urinary tract infections, neuropathic pain, peripheral neuropathy, hip osteoarthritis, cerebellum balancing, allergic rhinitis, treatment of hypolactation, depression, gynecological conditions, migraine, chronic prostatitis, and post stroke spastic hemiplegia. Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. Neuropathic Pain Depression Review
34367299 The role of acupuncture in reducing the anxiety and depression scores in patients with nausea during pregnancy has been reported previously. Evid Based Complement Alternat Med. 2021 Jul 27;2021:2731446. doi: 10.1155/2021/2731446. eCollection 2021. Nausea and Vomiting Anxiety Depression Review
34373915 Many existing reviews either do not synthesize this outcome or subsume depression outcomes within a catch-all mental health or quality of life outcome, exemplified in a recent synthesis of acupuncture. Pain Med. 2022 May 4;23(5):934-954. doi: 10.1093/pm/pnab248. Depression Review
34437474 Conversely, while in depression and embryo implantation disorders, acupuncture can move the Th1/Th2 balance toward Th2. Vet Sci. 2021 Jul 30;8(8):149. doi: 10.3390/vetsci8080149. Depression Review
34446530 Combined WM therapy with CHM appears to be better for improving depression than combined WM therapy with acupuncture. Stroke Vasc Neurol. 2022 Feb;7(1):77-85. doi: 10.1136/svn-2020-000781. Epub 2021 Aug 26. Depression Review
34456996 Indeed, acupuncture's function to reshape the brain is not limited to stroke, as a recent review of brain plasticity in animals revealed that acupuncture could modulate the plasticity of various central nervous systems, such as depression, neuropathic pain, Alzheimer's disease, and cerebral vascular disorders. Neural Plast. 2021 Aug 19;2021:2662585. doi: 10.1155/2021/2662585. eCollection 2021. Neuropathic Pain Depression Review
34489662 Several systematic reviews have indicated that acupuncture therapy may improve symptoms in various diseases, such as depression (Smith et al.,), ischemic stroke (Lu et al.,), migraine (Da,), functional diarrhea (Guo et al.,), and Alzheimer's disease (Huang et al.,). Front Hum Neurosci. 2021 Aug 20;15:694919. doi: 10.3389/fnhum.2021.694919. eCollection 2021. Depression Review
34489662 This kind of experimental design is used to observe the changes in brain response after acupuncture treatment, which is helpful to explore the mechanism of long-term acupuncture effect such as investigating the effect of different courses of acupuncture and among different patients, and it is suitable for chronic diseases, such as insomnia (Wang et al.,) and depression (Wang et al.,). Front Hum Neurosci. 2021 Aug 20;15:694919. doi: 10.3389/fnhum.2021.694919. eCollection 2021. Insomnia Depression Review
34489749 Magnetic Resonance Imaging Studies on Acupuncture Therapy in Depression: A Systematic Review Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Accumulating studies had been performed using magnetic resonance imaging (MRI) to understand the neural mechanism of acupuncture therapy for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Therefore, we aim to summarize the current MRI research and provide useful information for further research by identifying papers published in English and Chinese about MRI studies on acupuncture for depression up to November 2020. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 However, clear, reliable conclusions cannot be drawn due to the use of different designs, analytical methods, seed points selected, types of depression, acupuncture points, and so on. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Faced with limitations of conventional treatments, patients suffering from depression often seek alternative forms of treatment, such as acupuncture therapy, one of the world's oldest recognized medical treatments, which has been used to relieve pain and treat mental illness for 1,000's of years. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Indeed, several systematic reviews have shown that a single acupuncture therapy session or combination of acupuncture with a suitable adjunct was significantly effective in reducing the severity of depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 In traditional Chinese medicine (TCM) theory, the pathogenesis of depression is the stagnation of liver qi, and acupuncture can regulate qi and mental state. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 However, as we all know, humans are complex animals, and the mechanism of acupuncture in treating depression may be different between animal and human studies. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Therefore, it is very necessary to investigate the effects of acupuncture on depression at the human brain level. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Therefore, it is possible for us to explore changes in brain structure, function, and metabolism about acupuncture for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Importantly, with the increase of research in this area, the central mechanism of acupuncture's effect on depression is becoming more and more clear. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 However, there are few reviews of MRI studies on acupuncture for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Therefore, with our review, we aim to provide a systematic overview of the existing evidence regarding changes in brain structure, function, and metabolism underlying the effects of acupuncture therapy on depression by summarizing the characteristics, methods, and conclusions of relevant MRI research. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 We searched the following four electronic databases for clinical MRI research on acupuncture therapy for depression: PubMed, Wanfang, VIP information database, and China National Knowledge Infrastructure (CNKI) up to October 20, 2020. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 The keywords were as follows: (1) acupuncture therapy, acupuncture, acupuncture point, body acupuncture, auricular acupuncture, electroacupuncture, moxibustion; (2) depression, depressive disorder, major depression disorder; and (3) MRI, magnetic resonance imaging, resting state, fMRI, rs-fMRI, functional connectivity, task fMRI, BOLD, blood oxygen level-dependent, ReHo, ALFF, fALFF, voxel-based analysis, VBM, voxel-based morphometry, Freesurfer, surface based morphometry, cortical thickness, surface area, cortical volume, gray matter volume, gray matter density, GMV, DTI, diffusion tensor imaging, white matter, fractional anisotropy, mean diffusivity, magnetic resonance spectroscopy. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 (v) In addition, a total of seven were conducted to compare the brain response of verum acupuncture (VA) with SA on depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 The relatively consistent findings argue that acupuncture can modulate more brain activity, especially in the brain regions associated with depression compared with SA. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Regions of ALFF differences before and after acupuncture treatment in patients with depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 This systematic review was designed to summarize findings of MRI studies aimed at evaluating the neurological effects of acupuncture treatment for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Importantly, further meta-analysis using SDM-PSI was conducted with three studies to explore changes in ALFF after acupuncture for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Characteristics of MRI Study on Acupuncture Therapy for Depression Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Our systematic review was unable to find a study that investigates the relationship between subtypes of depression and efficacy of acupuncture based on MRI techniques. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Regarding the types of acupuncture, MA, EA, and LA are those most often used as treatment for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Moreover, animal studies have shown that the release of depression symptoms with acupuncture on GV20 and EX-HN3 may be related to decreasing serum corticosterone concentrations and increasing neurotransmitter levels (5-HT, Glu, and GABA) and protein levels of brain-derived neurotrophic factor (BDNF). Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 In view of these differences, additional research is necessary to confirm whether acupuncture treatment for depression produces consistent changes of ALFF values. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 In this study, to understand the seed-based resting-state FC regarding acupuncture therapy for depression, the seed points selected were the left ACC, dorsolateral prefrontal cortex, posterior hypothalamus (ph), ventromedial hypothalamic nucleus (vmh), paraventricular nucleus of hypothalamus (pa), PC/PCC, amygdala, and striatum. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Interestingly, a recent study supported the notion of the ACC as a promising predictor of antidepressant response, which further illustrates the importance of the ACC in the pathogenesis of depression and as a target of acupuncture treatment for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Therefore, the important implication of this study is that maybe we should explore more analytical methods to better explain the underlying neural mechanisms of acupuncture treatment for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Although this review provides a detailed overview of the current literature about MRI research on the neurological effects of acupuncture therapy for depression, some limitations need to be noted. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Therefore, it is difficult to determine the specific factor that affects the brain during acupuncture treatment for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 In addition, it is extremely hard to explore how FC was altered by acupuncture treatment for depression since different seed points were involved in related studies. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 Anyway, these correlations play an important role in understanding biomarkers on acupuncture treatment for depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 In addition, the sample size was also small, which limited the reliability of MRI mechanism research on the mechanism of acupuncture treatment of depression. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 In conclusion, MRI analytical methods of acupuncture treatment for depression include 1H-MRS, ReHo, (f)ALFF, FC, VBM, and DTI. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34489749 However, future studies need to apply more analytical methods of MRI to investigate the neurological effects of acupuncture treatment in depression in the future. Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. Depression Review
34675729 Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 Rodent studies suggest that acupuncture prolongs total sleep time and reduces depression-like behavior in PMI and PMD models, respectively. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Depression Review
34675729 In conclusion, acupuncture is a promising therapeutic strategy for comorbid depression and insomnia during perimenopause. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 A menopausal epidemiological study carried out in the US indicated that in women who primarily used alternative therapies including acupuncture to manage menopause-related depression, 1.0% were completely symptom free, 84.6% made symptoms get a little to a lot better, 12.5% showed no change in symptoms, and 1.9% reported the worsening of symptoms, which was slightly less effective than the conditions in women who primarily used anti-depressive or anti-anxiety agents for menopause-related depression (5.6% were completely symptom free, 88.6% made symptoms get a little to a lot better, 3.9% showed no change in symptoms, and 1.9% reported the worsening of symptoms). Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Anxiety Depression Review
34675729 This review aims to summarize and assess existing clinical and preclinical evidence of acupuncture as a treatment for perimenopausal insomnia and depression, as well as discuss the potential mechanisms involved. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 Effects and Safety of Acupuncture on Depression and Insomnia Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 As of March 2019, there were at least 31 systematic reviews and/or meta-analyses (SRs/MAs) regarding acupuncture treatment for depression. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Depression Review
34675729 How is Acupuncture for Perimenopausal Depression and Insomnia Conceptualised in TCM Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 We expect that these summaries will help clinicians and policymakers judge the role of acupuncture, and its potential and feasibility for the management of depression and insomnia associated with perimenopause. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 Many RCTs have missing components in their methodology, which dilutes and weakens the quality of evidence, and may hinder the development of acupuncture as a form of evidence-based healthcare for comorbid depression and insomnia during perimenopause. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 Potential mechanisms by which acupuncture may improve perimenopausal depression and insomnia. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 Acupuncture may also improve perimenopausal depression and insomnia by improving vasomotor symptoms, while this indirect effect is not shown. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 It is challenging to explore the mechanisms underlying the effects of acupuncture on depression and insomnia during the transition to menopause in only RCTs. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34675729 The effect of acupuncture in reinstating reduced hippocampal GABA content in rats with depression has been widely investigated and confirmed. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Depression Review
34675729 Both human clinical and animal studies have revealed the increases in serum 5-HT and/or hippocampal 5-HT and its major metabolites caused by acupuncture, along with decreased PMD symptoms or depression-like behaviors. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Depression Review
34675729 In addition to the enhancement of 5-HT synthesis and the increase of 5-HT and its metabolite content in the brain and synaptic gaps, previous studies also suggested that acupuncture restored synaptic plasticity by regulating serotonin expression in the hippocampus resulting in relieved depression symptoms. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Depression Review
34675729 These benefits of acupuncture were validated again in PMD rats and were accompanied by a significant reduction in depression-like behavior. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Depression Review
34675729 Despite some methodological deficiencies, acupuncture could be an adjunct therapy or viable and safe option for women with comorbid depression and insomnia during perimenopause. Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. Insomnia Depression Review
34721179 Trends of Acupuncture Therapy on Depression From 2011 to 2020: A Bibliometric Analysis Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Objectives: The purpose of this study was to explore the current status and trends of acupuncture for depression in the last decade and provide new insights for researchers in future studies. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Methods: The articles regarding acupuncture treatment for depression published between 2011 and 2020 were extracted from the Web of Science Core Collection. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 We used CiteSpace to analyze data on publications, countries, institutions, cited journals, cited authors, cited references, keywords, and citation bursts about acupuncture and depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 We identified the most prolific journals, countries, institutions, and authors in the field of acupuncture for depression in the last decade. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Conclusions: The results from this bibliometric study provide insight into the research trends in acupuncture therapy for depression, and the current status and trends of the past decade, which may help researchers determine the current status, hotspots, and frontier trends in this field. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Some meta-analyses showed that acupuncture is a safe and effective method for the treatment of depression (Li et al.,; Armour et al.,), with relatively few adverse effects (Smith et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Adverse Reactions Depression Review
34721179 More research effort is being devoted to the application of acupuncture for the treatment of depression (Li R. et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 However, little attention has been paid to topic hotspots and trends in acupuncture for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Meanwhile, it remains a question whether the number of publications in acupuncture treatment for depression changed over time. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 The previous retrospective analyses of acupuncture treatment for depression were mainly literature reviews and meta-analyses. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 However, a specific bibliometric analysis of acupuncture for depression has not yet been performed. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In this study, CiteSpace was searched to obtain data on the hot topics and research trends in the use of acupuncture treatment for depression during the last decade for the first time. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 The trends of acupuncture treatment for depression were subjected to a visualization analysis. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In the past 10 years, the annual number of publications on acupuncture treatment for depression fluctuated slightly. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In recent years, acupuncture treatment has received increasing attention, and the efficacy of acupuncture for the treatment of depression has also been the subject of more research. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 The annual number of publications on acupuncture for depression from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 The top 10 journals on acupuncture for depression are listed in Table 1. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 A systematic review and meta-analysis of 425 records showed that acupuncture can effectively alleviate depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 The scores on the 17-item Hamilton Rating Scale for Depression showed that acupuncture combined with selective serotonin reuptake inhibitors (SSRIs) was more effective than a single-drug treatment (Chan et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Cited journal maps related to acupuncture treatment for depression research from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In the United States, South Korea, England, and Australia, researchers pay more attention to acupuncture as a specific treatment for depression (Table 3). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Map of countries researching acupuncture for depression from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 A total of 153 institutions provided studies on acupuncture for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In particular, the China Academy of Chinese Medical Sciences was the institution with the highest centrality, suggesting that it is an important institution in the research on acupuncture for depression (Table 4). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Based on the numbers of publications and centrality, the institutions from China, the United States, South Korea, and other countries pay the most attention to acupuncture on depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Map of institutions researching acupuncture for depression from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Future collaborations among these authors would yield more studies on acupuncture for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Map of co-authors related to acupuncture for depression from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 By analyzing co-citation frequency and centrality, this study provided fundamental data on the research on acupuncture for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Map of cited references related to acupuncture for depression from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Map of keyword occurrences related to acupuncture for depression from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 We performed a bibliometric analysis in the area of acupuncture for treating depression with CiteSpace by searching the Web of Science Core Collection from 2011 to 2020. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In the past 3 years, the number of publications on acupuncture treatment for depression has increased rapidly. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 The most prolific countries in terms of research on acupuncture for depression are China and the United States. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Acupuncture for depression is now widely accepted and actively researched in China in terms of the number of publications. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In the past few decades, acupuncture has increased in popularity in the United States, and its positive effects on pain, pregnancy, depression, etc., have been confirmed (Bishop et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 This indicates that China maintains a high degree of cooperation with other countries and institutions engaged in the research on acupuncture treatment for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Collaborations help researchers share information and ideas, which is very important for further development in the field of acupuncture treatment for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Professor Zhang published many research papers on randomized controlled trials of the acupuncture treatment for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 A randomized controlled trial by this author showed that, compared with minimum acupuncture stimulation, dense cranial electroacupuncture stimulation plus body acupuncture can significantly alleviate post-stroke depression, functional disability, and the cognitive deterioration of stroke patients, but the subjects of this study included ischemic and hemorrhagic stroke, so their pathological characteristics and symptom severity may be different (Zhang et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In a single-blind randomized controlled study, Zhang-Jin Zhang showed that dense cranial electroacupuncture stimulation plus SSRIs significantly alleviated major depression after 3 weeks based on the 17-item Hamilton Depression Rating Scale compared with SSRIs alone in the early phase (Zhang et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In recent years, professor Park Hi-Joon has published papers about acupuncture that are not directly related to depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 A randomized controlled trial, a coping strategy, a questionnaire, Beck's depression inventory, and the State-Trait Anxiety Inventory were used to evaluate the therapeutic effects of acupuncture on chronic sciatica (Kim et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Anxiety Depression Review
34721179 In another randomized controlled trial, the feasibility and efficacy of acupuncture for atopic dermatitis (including pruritus) were evaluated using instruments including the Center for Epidemiologic Studies Depression Scale (Kang et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 These studies were not to clarify the efficacy and mechanism of acupuncture in the treatment of depression but to use the depression assessment scale. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Acupuncture for depression-related insomnia may be an alternative to drug therapy (Dong et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Insomnia Depression Review
34721179 The first review found insufficient evidence to support the view that acupuncture is ineffective for depression, mainly due to the high risk of bias in most trials meeting the inclusion criteria (Smith et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In the second review, acupuncture is a potentially effective monotherapy for the treatment of depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In the third review, the acupuncture group had superior outcomes to antidepressant and waiting list control groups in terms of post-stroke depression and symptom severity. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Prenatal acupuncture reduced depression, stress, and pain and improved the quality of life without adverse reactions (Ormsby et al.,). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Adverse Reactions Depression Review
34721179 A systematic review and meta-analysis demonstrated the efficacy of acupuncture in the treatment of postpartum depression (PPD). Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 The Hamilton Depression Scale of the acupuncture group was significantly better than those of the control group, and efficacy was significantly higher for the acupuncture than the control group. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Another meta-analysis evaluates the effect of acupuncture on post-stroke depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Second, using CiteSpace, more types of depression, acupuncture methods, and diseases need to be analyzed in the future. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 In summary, this study provided useful data for potential collaborations among researchers and institutions and identified hot topics and trends in the research on acupuncture treatment for depression. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34721179 Acupuncture appears effective in the treatment of depression, but more evidence is still required. Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. Depression Review
34729102 The results regarding whether acupuncture could improve cancer-related anxiety and depression are controversial. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 24 for sham-acupuncture) revealed that acupuncture has no significant effect to improve anxiety and depression associated with the treatment of aromatase inhibitors (AIs); whereas another clinical trial showed that EA could significantly improve anxiety and depression associated with AIs treatment in breast cancer patients. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 Meanwhile, a clinical trial including 302 breast cancer patients showed that acupuncture could improve cancer-related anxiety and depression. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 One study, using depression as the primary outcome, illustrated that acupuncture can effectively reduce malignancy-related depression. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Depression Review
34729102 In summary, large clinical trials assessing anxiety and depression as the primary outcome need to be conducted to evaluate the role of acupuncture in cancer-related anxiety and depression. J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Anxiety Depression Review
34729102 This review summarized the application of acupuncture and EA in cancer patients for improving cancer-related symptoms and side-effects, such as fatigue, insomnia, chemotherapy-associated dyspepsia syndrome (CADS), radiation-induced xerostomia (RIX), anxiety and depression, and pain (Table 1). J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. Side Effects Insomnia Anxiety Depression Review
34992414 Acupuncture stimulation at Shenmen (HT7) alleviated the behavioral impairment (immobility time) and reduced the plasma levels of corticosterone, IL-1β, IL-6 and glial cell-derived neurotrophic factor by maternal separation, indicating that acupuncture helps to relieve maternal separation-induced depression. J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. Depression Review
35085351 Compared with sham acupuncture, acupuncture was not significantly better at relieving anxiety (standardized mean difference [SMD] -0.35, 95% CI −1.05 to 0.33) and depression (SMD -0.32, 95% CI −0.71 to 0.07) symptoms. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Compared with pharmacotherapy, acupuncture was significantly better at relieving anxiety (SMD -0.64, 95% CI -0.93 to -0.35) and depression (SMD -0.46, 95% CI -0.69 to -0.22) symptoms. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Evidence has shown that acupuncture can relieve gastrointestinal symptoms of FGIDs and emotional symptoms such as depression and anxiety. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Mood Review
35085351 Forest plot of comparison: Acupuncture versus sham acupuncture, outcome: Severity of anxiety and depression at the end of treatment. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 The pooled data showed that acupuncture was not significantly better at relieving depression symptoms than sham acupuncture (SMD -0.32, 95% CI −0.71 to 0.07, I2 = 54%, Fig 2B), and we also constructed a drapery plot (S7 Fig in S1 File) to visualize the results. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Depression Review
35085351 The sensitivity analyses showed that acupuncture reduced depression symptoms more than the control when the study Da2014 was omitted (SMD -0.44, 95% CI -0.84 to -0.03, S8 Fig in S1 File), but the effect was very small. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Depression Review
35085351 Moreover, the subgroup analysis based on disease showed that acupuncture may not be superior in relieving depression symptoms in patients with IBS, FD, FC and FDr compared with sham acupuncture (Fig 2B). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Depression Review
35085351 The subgroup analysis based on acupoints showed that acupuncture prescriptions include acupoints for tranquilization, may be more useful in relieving depression symptoms in patients with FGIDs than sham acupuncture (S9 Fig in S1 File). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Depression Review
35085351 The subgroup analysis based on type of acupuncture showed that no matter electroacupuncture or manual acupuncture could relieve depression symptoms in patients with FGIDs to a greater degree than the control (S8 Fig in S1 File). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Depression Review
35085351 The analysis of pooled data indicated that acupuncture was significantly better at improving depression symptoms than pharmacotherapy (SMD -0.46, 95% CI -0.69 to -0.22, I2 = 79%, Fig 4); we constructed a drapery plot to visualize the results (S15 Fig in S1 File). PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Depression Review
35085351 Forest plot of comparison: Acupuncture versus pharmacotherapy, outcome: Severity of depression at the end of treatment. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Depression Review
35085351 The pooled results showed that acupuncture was relatively effective in relieving anxiety and depression symptoms in patients with FGIDs, but the current evidence does not explain whether this effect is a placebo effect. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Acupuncture at Tianshu, Zusanli, and Shangjuxu can regulate the balance of the gut microbiome, and gut microbiome dysbiosis is an important cause of depression and anxiety. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 Compared with pharmacotherapy, acupuncture reduced anxiety and depressive symptoms in patients with FD, IBS and FDr and alleviated anxiety symptoms in patients with FC, but there was no significant difference in the scores for depression symptoms in patients with FC. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35085351 This showed that acupuncture treatment for depression and anxiety symptoms in patients with FC was at least equivalent to mosapride. PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. Anxiety Depression Review
35168522 Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 This review aimed to: (1) summarize the available evidence on the mechanisms and clinical effectiveness of acupuncture for depression, and then (2) compare with pharmacological interventions, guiding future studies. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Studies with animal models of depression and patients have shown that acupuncture could increase hippocampal and network neuroplasticity and decrease brain inflammation, potentially to alleviating depressive disorders. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Overall clinical studies indicated that acupuncture could relieve primary depression, particularly milder cases, and was helpful in the management of post-stroke depression, pain-related depression, and postpartum depression both as an isolated and adjunct treatment. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 In summary, substantial evidence from animal and human researches supported the beneficial effect of acupuncture in depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Given the growing body of literature on the effectiveness and neurobiological pathways underlying acupuncture for major depressive disorder, it is time to synthesize and review the available evidence on the mechanism and clinical effectiveness of acupuncture for depression in comparison to pharmacological interventions consolidating its effectiveness and guiding future studies. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 As an isolated and adjunct treatment, acupuncture has been emerging as a potential therapeutic regimen to treat depression with two main styles, acupuncture (manual) and electroacupuncture. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 PROPOSED MECHANISMS OF ACUPUNCTURE FOR DEPRESSION Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Acupuncture, as a comprehensive treatment in depression, has the potential to alleviate depressive symptoms by targeting neuronal and synaptic remodeling and immune response. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Immunity Depression Review
35168522 Acupuncture may act in a variety of ways, such as stimulating biochemical pathways and restoring neuronal structures in patients with depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Electroacupuncture at GV20 and GV29 acupoints could ameliorate the depression-like behaviors and markedly promoted nerve regeneration by increasing BDNF expression in the hippocampus. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 In addition, acupuncture at Shenmen (HT7) also upregulated the expression of BDNF in the PFC, suggesting that acupuncture has neuroprotective effects in depression via up-regulating BDNF (Fig. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Neuroprotection Depression Review
35168522 Acupuncture, as a non-invasive method of VNS, may be a potential therapeutic regimen to treat the inflammatory response in depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 It was naturally postulated that acupuncture is a promising non-pharmacology treatment for depression through the exciting vagal nerve to suppress the inflammatory responses in the peripheral and central systems. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Therefore, we proposed an assumption that acupuncture may act on the following two pathways to suppress the inflammation and ameliorate depression: (1) inhibition of the release of inflammatory cytokines by activating the vagal nerve; (2) regulation of the brain-gut axis through intestinal microbiota. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 There is a plausible assumption that acupuncture could increase endorphin expression, which suppressed the inflammation via µ-opioid receptors, in turn, ameliorated depression, especially in post-stroke depression (PSD) and pain-related depression (PRD), which were associated with inflammation. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 The increasing of endorphins release in individuals may be another acceptable explanation for the beneficial effects of acupuncture in primary depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Studies with animal models of depression and patients have shown that acupuncture can increase brain regions and network neuroplasticity and decrease brain inflammation, in turn, have the potential to alleviate the depressive disorder. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 CLINICAL EVIDENCE FOR ACUPUNCTURE ON DEPRESSION Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Besides, an RCT compared SSRIs alone versus SSRIs together with manual acupuncture or electroacupuncture in 477 moderate to severely depressed patients, identifying that compared with SSRIs alone, both manual acupuncture and electroacupuncture were significantly better on 17-item Hamilton Depression Rating Scale (HDRS) response rate, HDRS-17 early-onset rate, Self-Rating Depression Scale (SDS), Clinical Global Impression (CGI) and Rating Scale foe Side Effects (SERS), indicating that acupuncture have therapeutic effects in addition to SSRIs alone in patients with moderate to severe depression, and was well tolerated. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Side Effects Depression Review
35168522 A significant focus of acupuncture has been placed on secondary depression, which has a similar pathophysiological mechanism to primary depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Among secondary depressive disorders, PSD, PRD, and postpartum depression (PPD) are the most common diseases in acupuncture. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Based on current procurable evidence, the significant effects of acupuncture in ameliorating depression were manifested in patients compared with both usual care and waiting-list. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 A system review involving 31 trials with 2,257 participants in the subacute or chronic stages of stroke found that acupuncture had therapeutic effects on the improvement of depression and dependency, global neurological deficiency, and some specific neurological impairments. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Besides, subgroup analysis further showed that acupuncture alone was superior to medication in improving depression-associated symptoms, but was no statistically significant difference between acupuncture combined with medicine groups. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Acupuncture, as a unique treatment of traditional Chinese medicine, played a therapeutic role through multiple targets, such as both treating pain and improving depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Therefore, acupuncture has been reported as a potential alternative treatment for patients with depression and pain comorbidities. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 This clinical study found that compared with the waiting-list group, acupuncture fared significantly better for the pain and depression assessment by the Allgemeine Depressionsskala scale (ADS) after 8-week treatment. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 After treatment, acupuncture improved the pain and depression compared with sham acupuncture, which was again significantly different at 6 months and 3 years follow-ups. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 A secondary analysis of an RCT with 755 patients also found that acupuncture was most marked in the reduction of depression and pain compared with counseling or usual care. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Concomitant with the rising use of acupuncture in pain, the comorbidities of depression and pain are drawing public attention. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 In most cases, acupuncture was effective for both depression and pain. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Despite the interest, most studies focused on pain, and very little work has addressed depression and its causal relationship to pain in the treatment of acupuncture. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Current studies indicated that compared with medical treatment, acupuncture has therapeutic effects in reducing pain and relieving symptoms of depression in patients with PRD. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Acupuncture was acceptable to pregnant women who were not utilizing conventional approaches, as well as an adjunct for those using standard depression therapeutics. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Therefore, it may be more suitable to receive the treatment of acupuncture for depression in postpartum women. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 A systematic review and meta-analysis involving 8 prospective trials with 517 participants also found that acupuncture decreased the score of depression but no beneficial effects in clinical response and estradiol. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 By contrast, another systematic review and meta-analysis including 9 trials with 653 women demonstrated that compared with the control group, acupuncture could obviously improve the overall effective rate and increase oestradiol levels, but there was no difference in depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 An RCT involved 57 PPD patients found that compared with muscle relaxation or usual care, there was a significantly lower depression score after acupuncture treatment without adverse event. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Similarly, another trial with 150 PPD who were randomized to receive either acupuncture specific for depression or one of two active controls: control acupuncture or massage, also found that compared with the control group, acupuncture got a greater rate of decrease in symptom severity and response. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 However, a double-blind RCT involving 20 PPD women who received electroacupuncture or non-invasive sham acupuncture two sessions weekly for four weeks found that electroacupuncture and sham acupuncture both reduced the score of HDRS, Edinburgh Postnatal Depression Scale, Hospital Anxiety and Depression Scale and Clinical Global Impression and was no significant difference between two groups. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Anxiety Depression Review
35168522 Pregnant women suffering from depression are willing to try acupuncture, despite having little prior knowledge of it, indicating that there is an increasing demand for acupuncture in the PPD field. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Acupuncture may be more Effective or Suitable in Some Depression Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 This study found that there was no difference between the two groups in depressive scores, menopause-specific quality of life, and serum sexual hormones, indicating that electroacupuncture was effective and safe in relieving depression symptoms and improving the quality of life. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Similarly, a small RCT with 30 patients with mild to moderate depression who were randomized to receive active or inactive (sham) laser acupuncture found that compared with sham acupuncture, the decreasing of the depressive score was higher in laser acupuncture, indicating that acupuncture may be worth further investigation as a treatment for mild to moderate depression in primary care. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Therefore, acupuncture may be potentially effective monotherapy for mild to moderate depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 There are improvements of depressive symptoms by medication in some special patients, including PPD and geriatric depression, and these improvements have also been seen in non-pharmacological treatment, including acupuncture. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Acupuncture may be an Adjunct Treatment in Severe Depression Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 Meanwhile, a growing body of evidence from RCTs found that compared with placebo, using anti-inflammatory medicine alone also significantly improved the depression, and acupuncture, as a non-invasive method of VNS, maybe a potential therapeutic regimen to treat the inflammatory response in depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 These findings indicated that combination or augmentation strategies of antidepressants with acupuncture are more effective and have an early onset of action in severe depression Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 In addition, overall clinical studies indicated that acupuncture could relieve primary depression, particularly milder cases, and was helpful in the management of PSD,PRD and PPD both as an isolated and adjunct treatment. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35168522 In summary, substantial evidence from animal and human researches supported the beneficial effect of acupuncture in depression. Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. Depression Review
35241146 In recent years, clinical trials of acupuncture registered and carried out worldwide involve the evaluation of limb motor function, limb spasm and pain, swallowing function, activities of daily living, quality of life, cognitive function, depression, and anxiety state, etc., both in acute and recovery phase of ischemic stroke. Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. Cognitive Function Anxiety Depression Motor Function Review
35280507 However, acupuncture is also used to treat depression. Evid Based Complement Alternat Med. 2022 Mar 3;2022:6847917. doi: 10.1155/2022/6847917. eCollection 2022. Depression Review
35449821 maintained that for stroke patients in the subacute or chronic phase, acupuncture may mitigate neurological deficits, such as motor function, cognitive function, depression, swallowing function, pain, and spasticity. Evid Based Complement Alternat Med. 2022 Apr 11;2022:7705256. doi: 10.1155/2022/7705256. eCollection 2022. Cognitive Function Depression Motor Function Review
35449821 In addition, acupuncture is found relatively more effective and safer than antidepressants in the treatment of poststroke depression. Evid Based Complement Alternat Med. 2022 Apr 11;2022:7705256. doi: 10.1155/2022/7705256. eCollection 2022. Depression Review
35492706 The Role of Acupuncture in the Management of Insomnia as a Major or Residual Symptom Among Patients With Active or Previous Depression: A Systematic Review and Meta-Analysis Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Due to concerns about risks associated with antidepressants and/or hypnotics, complementary therapies such as acupuncture have been sought by patients with active or previous depression to manage insomnia. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 This systematic review aimed to clarify if acupuncture is effective and safe enough to be recommended as an alternative or adjuvant therapy to standard care in ameliorating concomitant or residual insomnia, two types of insomnia associated with depression. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Randomized controlled trials (RCTs) of depression-related insomnia (DI) treatment via acupuncture vs. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 For insomnia as a major symptom of active depression, meta-analyses suggested that acupuncture significantly reduced the global scores of both the Pittsburg Sleep Quality Index (PSQI) [MD = −3.12, 95% CI (−5.16, −1.08), p < 0.01] and Hamilton Depression Scale (HAMD) [SMD = −2.67, 95% CI (−3.51, −1.84), p < 0.01], in comparison with placebo-acupuncture. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Sleep Quality Review
35492706 For insomnia as a residual symptom of previous or partially remitted depression, acupuncture conferred a very limited, non-significant therapeutic advantage against sham-/placebo-acupuncture. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 There is a low to moderate level of evidence supporting acupuncture as a safe and effective remedy alternative to or adjuvant to conventional pharmacotherapy (antidepressant and/or hypnotic) in improving insomnia and other depression symptoms among patients with active depression. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 The benefit of acupuncture on residual insomnia associated with previous or partially remitted depression is limited. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 The search was carried out by combining search terms from four categories: (1) acupuncture, (2) depression, (3) insomnia, and (4) RCT. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 A predetermined data form was employed to extract the following information (demographic and clinical characteristics) from each study: identification information, publication year, types of DI (insomnia as a major symptom or a residual symptom of depression), grouping methods as well as number and gender of participants in each group, duration of DI, diagnostic criteria employed, TCM syndrome pattern of DI included, intervention protocols including acupuncture frequency, session and duration as well as acupoint selection, prescription in comparator (frequency, session, and duration in placebo-/sham-acupuncture; or type, dosage, and oral frequency of Western medication; or regimen of CBT-i), outcome measures, results, follow-up duration and results, and adverse events (AEs). Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Of the 21 trials, two trials investigated the efficacy of acupuncture for depression-associated residual insomnia using a three-arm design with both placebo-acupuncture and sham-acupuncture as controls. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 The remaining 19 trials investigated the efficacy of acupuncture for active depression accompanying or comorbid with insomnia. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 In the first category (the therapeutic effect of acupuncture on insomnia as a major symptom of active depression), we further split the analyses into three sections: (1) acupuncture vs. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 In the second category (the therapeutic effect of acupuncture on insomnia as a residual symptom of previous or partially remitted depression), we only qualitatively described the results because there were not enough RCTs (n < 3) to conduct meta-analysis (Appendix 7). Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Effect of Acupuncture on Insomnia as a Major Symptom of Active Depression Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Effect of Acupuncture on Insomnia as a Residual Symptom of Previous or Partially Remitted Depression Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Among patients with insomnia as a major symptom in active depression (that is, depression accompanying/comorbid with insomnia), acupuncture appeared to be superior to either placebo-acupuncture or antidepressants and/or hypnotics in improving both poor sleep and depressive symptoms. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 In the treatment of patients with insomnia as a residual symptom in previous or partially remitted depression, acupuncture appeared to only possess marginally better efficacy than placebo-acupuncture and had no superior efficacy to sham-acupuncture, indicating that the observed differences between verum- and placebo-acupuncture might be due to non-specific effects of needling. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 To the best of our current knowledge, this is the first systematic review and meta-analysis comprehensively investigating the collective evidence regarding the efficacy of acupuncture as an alternative or adjuvant management to standard care in the management of insomnia as a major or residual symptom among patients with active or previous/partially remitted depression. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 In addition to the stricter selection criteria and usage of widely accepted analysis tools as mentioned above, the merits of our current review also included the following: (1) considering the distinct clinical characteristics between two types of DI, the therapeutic effect of acupuncture on them was separately analyzed and different conclusions were drawn; (2) with limited data synthesis (derived from three RCTs), we were the first to report the significant efficacy differences between verum- and placebo-acupuncture on insomnia as a major symptom among patients with depression; (3) the STRICTA checklist and the GRADE system were introduced to appraise the reporting quality and evidence quality, respectively; and (4) we provided a complete list of excluded studies with justification for the exclusion of each, so as to present a transparent and comprehensive screening process and enable readers to determine whether there is a risk of unjustified exclusion. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Since ancient times, acupuncture has been used to treat insomnia and/or depression. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 In the past decade, at least 31 systematic reviews and at least 34 systematic reviews investigating the treatment of depression and insomnia, respectively, with acupuncture, have been published, reflecting the continuous growth of attention and research interest in the management of psychological and sleep disorders by using acupuncture in the international medical community. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Thus, acupuncture is significantly better than placebo and at least equivalent to standard care in improving poor sleep among patients with depression. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Depression Review
35492706 Nevertheless, there was no significant difference between acupuncture with low-frequency treatment sessions (<5 sessions per week) and standard care in improving both insomnia and depression symptoms among patients. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 On the basis of these findings, we here recommend that, when delivering acupuncture treatment for patients with active depression and concomitant insomnia, clinical practitioners may consider increasing the frequency of acupuncture treatment, such as providing five treatment sessions per week, to enhance the hypnotic effect of acupuncture. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Although the search was comprehensive, only two trials from the same research team concerning acupuncture for depression-associated residual insomnia were identified. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 Therefore, other potentially effective therapies (including combined application of acupuncture and hypnotic/antidepressant/CBT-i/repetitive transcranial magnetic stimulation) also need to be actively sought and determined; after all, the available evidence does not, in any case, support the use of acupuncture alone in managing residual insomnia associated with previous or partially remitted depression. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 A previous systematic review revealed that acupuncture was helpful in reducing antidepressant-induced side reactions in the first 6 weeks of the treatment period among patients with depression. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Side Effects Depression Review
35492706 Since acupuncture has not been proven to be effective for residual insomnia associated with previous or partially remitted depression, we do not recommend any acupoints for this type of insomnia. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35492706 It is hence indeterminate whether the observed change in REM-SOL was a manifestation of the development of depression over time or whether it was caused by acupuncture. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Depression Review
35492706 This review has provided a low to moderate level of evidence supporting acupuncture as a safe and effective remedy alternative to or adjuvant to conventional pharmacotherapy (antidepressant and/or hypnotic) in improving insomnia as a major symptom among patients with active depression as well as their depressed mood. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Mood Review
35492706 The effect of acupuncture on residual insomnia associated with previous or partially remitted depression requires further research employing optimal dosage of treatment. Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. Insomnia Depression Review
35586692 reported that acupuncture at Nei Guan (PC6) significantly reduced CORT-induced anxiety and depression behaviors in rats and increased the expression of neuropeptide Y in the hypothalamus. Evid Based Complement Alternat Med. 2022 May 9;2022:4807271. doi: 10.1155/2022/4807271. eCollection 2022. Anxiety Depression Review
35586692 This finding indicates that acupuncture may alleviate anxiety and depression in the patients by regulating the HPA axis, thus effectively treating ED. Evid Based Complement Alternat Med. 2022 May 9;2022:4807271. doi: 10.1155/2022/4807271. eCollection 2022. Anxiety Depression Review
35725779 Acupuncture has been used in managing various symptoms and diseases such as anxiety, depression, low back pain, inflammatory bowel disease, and cancer symptoms. Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. Anxiety Depression Inflammatory Pain Review
35832139 The following topics were included: post-stroke depression; non-invasive brain stimulation; behavioral therapy; psychosocial interventions; acupuncture; exercise therapy; light therapy; music therapy and art therapy. Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. Depression Review
35832139 In a randomized control trial of more than 270 patients, He et al noted a superior therapeutic effect of acupuncture performed twice a day for one month, with a notable improvement in Self-Rating Depression Hamilton Depression scales. Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. Depression Review
35832139 Furthermore, it has also been suggested that patients with good motor function at onset who have received acupuncture for at least a month show a greater degree of improvement in their scores in the Beck Depression and HRDS compared to those with severe motor disability. Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. Depression Motor Function Review
35832139 Patients who received DCEAS in combination with SSRI and body electroacupuncture had better outcomes as measured by the Hamilton Depression Rating Scale (HAMD-17) and the Clinical Global Impression-Severity scale (CGI-S), and improvements have been noted as early as one week post treatment Two recent meta-analyses in 2019 and 2020 corroborate these findings, concluding that acupuncture combined with conventional drug therapy is more effective versus standard antidepressant alone. Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. Depression Review
35832139 To date, the American Heart Association (AHA) recommends acupuncture as an add-on management for post-stroke complications such as dysphasia and shoulder pain, but not specifically for post-stroke depression. Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. Depression Review
35832139 When combined with acupuncture, it provides more substantial reduction in depression scores among post-stroke patients. Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. Depression Review
35910879 Reliability of Evidence to Guide Decision-Making in the Use of Acupuncture for Postpartum Depression Front Public Health. 2022 Jul 14;10:942595. doi: 10.3389/fpubh.2022.942595. eCollection 2022. Depression Review
35910879 There is conflicting evidence on the effectiveness of acupuncture in the treatment of postpartum depression (PPD). Front Public Health. 2022 Jul 14;10:942595. doi: 10.3389/fpubh.2022.942595. eCollection 2022. Depression Review
35910879 The following eligibility criteria were used to screen studies: (a) SRs/MAs based on randomized controlled trials (RCTs) on the use of acupuncture to treat PPD; (b) participants diagnosed with PPD by a recognized guideline; (c) interventions included acupuncture therapy or acupuncture plus conventional medication (CM), while the control group was treated with CM, CM plus acupuncture, sham acupuncture, or other non-pharmacological therapy; (d) outcomes included the Hamilton Rating Scale for Depression (HAMD), Edinburgh Postnatal Depression Scale (EPDS), effective rate and estradiol levels. Front Public Health. 2022 Jul 14;10:942595. doi: 10.3389/fpubh.2022.942595. eCollection 2022. Depression Review
35910879 The following search terms were applied: postpartum depression, acupuncture, meta-analysis, and systematic review. Front Public Health. 2022 Jul 14;10:942595. doi: 10.3389/fpubh.2022.942595. eCollection 2022. Depression Review
35910879 All studies used the HAMD to assess the severity of depression, and one review concluded that acupuncture treatment improved depressive symptoms more significantly than CM, however, five reviews showed no significant difference between the two groups. Front Public Health. 2022 Jul 14;10:942595. doi: 10.3389/fpubh.2022.942595. eCollection 2022. Depression Review
36011540 Acupuncture and dry needling therapies seems to be effective in patients with FM, since both reduced pain pressure thresholds, anxiety, depression, fatigue, sleep disturbances and disability in the short term. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. Insomnia Anxiety Depression Review
36011540 The main findings of this meta-analysis were that dry needling could induce a short-term improvements in pain, quality of life, vitality, social function, psychological and severity in patients with FM in comparison with other techniques (e.g., manual myofascial release, cross tape) and that acupuncture, if combined with other treatments, is also an effective technique to reduce the ingestion of analgesics and to improve pain perception, quality of life, pain perception, depression and anxiety from the short-term to up to 12 months. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. Anxiety Depression Review
36011540 The same level of evidence supports acupuncture as an effective complementary treatment to medication and exercise for improving FM severity and symptoms including pain, sleep quality, quality of life, depression, anxiety and fatigue. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. Anxiety Depression Sleep Quality Review
36081895 The results showed that High-Frequency Repetitive Transcranial Magnetic Stimulation (HfrTMS), Acupuncture/EA+conventional treatment, Escitalopram, Modified Sini San, Moxibustion, Xiaoyao Formula, Paroxetine, Chinese herbal medicine, Exercise, Citalopram, and Cognitive behavioral therapy are beneficial for improving the depression symptoms of patients with PSD. Front Aging Neurosci. 2022 Aug 23;14:993250. doi: 10.3389/fnagi.2022.993250. eCollection 2022. Depression Review
36117653 Meanwhile, some common treatment strategies for depression in PCOS, such as lifestyle intervention, acupuncture, oral contraceptive pills, psychological intervention, and insulin-sensitizer, are also reviewed. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Depression Review
36117653 Acupuncture therapy is widely used in the treatment of depression, and has good efficacy in alleviating PCOS symptoms. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Depression Review
36117653 One study reported reduced BMI, Ferriman-Gallway score, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores, while PCOS health-related quality of life questionnaire scores, serum sex hormone binding globulin (SHBG) levels and β -endorphin levels were elevated after acupuncture intervention in PCOS patients. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Anxiety Depression Review
36117653 These results indicated that acupuncture therapy can effectively relieve depression in PCOS patients, and the mechanism may be related to the regulation of serum β-endorphin and androgen levels. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Depression Review
36117653 Another secondary investigation to assess how electroacupuncture affected anxiety and sadness in unmarried women with PCOS found that acupuncture could alter serum norepinephrine (NE) and 5-HT levels and thereby lessen PCOS depression symptoms. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Anxiety Depression Review
36117653 According to previous studies, PCOS-induced depression can be effectively treated with acupuncture, oral contraceptives, psychological therapy, and insulin sensitization agents. Front Psychiatry. 2022 Aug 31;13:1001484. doi: 10.3389/fpsyt.2022.1001484. eCollection 2022. Depression Review
36119472 (A) the changes measured by the Self-Rating Anxiety Scale in lung cancer patients treated with acupuncture-related intervention versus control from the baseline to the end of treatment; (B) the changes measured by Self-Rating Depression Scale in lung cancer patients treated with acupuncture-related intervention versus control from the baseline to the end of treatment. Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. Anxiety Depression Review
36119472 Compared with control groups such as usual care and pharmacotherapy, using acupuncture alone or in combination with other treatments can effectively relieve PROs, including postoperative chronic pain, and reduce anxiety and depression, so as to improve their QOL, which has a certain clinical application value. Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. Anxiety Depression Review
36148057 In recent years, with the development of the mechanism of acupuncture in analgesia, anti-inflammatory and nerve regulation, and effects in withdrawal syndrome, weight loss, and blood pressure regulation, acupuncture has become a potential therapeutic method for reducing cardiovascular disease risk factors, reducing the number of acute attacks, improving the results of electrocardiography, and alleviating anxiety and depression. Front Cardiovasc Med. 2022 Sep 6;9:920491. doi: 10.3389/fcvm.2022.920491. eCollection 2022. Cardiovascular Anxiety Blood Pressure Depression Review
36268156 TCM non-drug therapy (acupuncture, moxibustion, massage, and auricular point pressing beans) can significantly improve the PSQI score of patients after treatment and improve the degree of anxiety and depression of patients, with significant effect, which is worthy of clinical promotion. Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. Anxiety Depression Review
36268156 In this study, 16 high-quality RCT studies with a total of 1285 participants were included, and the results showed that non-drug therapy of TCM (acupuncture, moxibustion, massage, and auricular point pressing beans) could significantly improve the PSQI score of patients after treatment, the effective rate was significantly higher than that of the control group, and the improvement of anxiety and depression was better than that of the control group. Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. Anxiety Depression Review
36268156 The results showed that TCM non-drug therapy (acupuncture, moxibustion, massage, and auricular point pressing) could significantly improve the PSQI score of patients after treatment, with an effective rate significantly higher than that of the control group, and the improvement of anxiety and depression was better than that of the control group. Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. Anxiety Depression Review
36340786 Acupuncture has decreased anxiety and depression and increased self-esteem in migraineurs. Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. Anxiety Depression Review
36340786 Decreased ALFF and increased ReHo values in the ACC after verum acupuncture treatment in different subtypes of migraine and showed associations with decreased self-reported anxiety, self-reporting depression, and VAS score. Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. Anxiety Depression Review
36340786 Acupuncture has been discussed to have nonspecific modulation effects on a number of brain regions, implicated in the regulation of nociceptive perception and emotional disorders (e.g., anxiety and depression). Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. Anxiety Depression Mood Review
36353235 It has been reported that acupuncture can improve depression and anxiety scores in women with PCOS. Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. Anxiety Depression Review
36353235 Our previous research manifested that acupuncture can effectively relieve anxiety and depression in patients with PCOS, and its mechanism may be related to the regulation of the levels of serum β-endorphin and androgen. Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. Anxiety Depression Review
36381700 Acupuncture improved pain scores, measures of disability, and depression. These results remained consistent even after excluding randomized controlled trials with a risk of potential bias. Cureus. 2022 Oct 5;14(10):e29963. doi: 10.7759/cureus.29963. eCollection 2022 Oct. Depression Review
36408345 Notably, a previous study has shown that acupuncture improves depressive symptoms in patients with severe depression and activates the brain reward circuit. Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. Depression Review
36408345 Acupuncture, including electroacupuncture, can significantly inhibit pain sensation with the immediate analgesic effect and improve pain-induced negative emotions, including anxiety and depression accompanied by pain and cognitive changes. Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. Analgesic Effect Anxiety Depression Mood Review
36439200 A Cochrane review included 31 trials with a total of 2,257 participants in the subacute or chronic stages of stroke, and found that compared with no acupuncture, acupuncture was beneficial for the improvement of dependency, global neurological deficiency, and specific neurological impairments including motor, cognitive, and swallowing functions, as well as depression and pain (Yang et al.,). Front Cell Neurosci. 2022 Nov 10;16:817732. doi: 10.3389/fncel.2022.817732. eCollection 2022. Depression Review
36509453 Acupuncture is widely accepted as a therapeutic option for managing depression. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 This review aims to synthesize the best available evidence on the efficacy and safety of acupuncture in managing depression. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Randomized clinical trials of acupuncture for managing depression, published in English, were selected for inclusion. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 The treatment ranking of different interventions in improving depression symptoms indicated that EA plus antidepressant with a probability of 0.8294, followed by manual acupuncture (MA) plus antidepressant (0.6470) and MA (0.5232). Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Acupuncture, either in isolation or as an adjunct to pharmacological treatment, has clinical benefits and can be considered a safe option for managing depression. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Complementary and alternative medicine, such as acupuncture, are frequently used for people with depression (Hansen & Kristoffersen, ). Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Acupuncture has been shown to affect the nervous system and provide advantages for treating depression (L. Lu et al., ; Shin et al., ). Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 In recent decades, there has been an increasing number of RCTs and systematic reviews assessing the efficacy of acupuncture for depression. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Some systematic reviews have detailed the beneficial effects of acupuncture in reducing the severity of depression and suggested it may be a suitable adjunct to usual care (UC) and standard antidepressant medication (Armor et al., ; Stub et al., ); while other studies have found insufficient evidence for the efficacy of acupuncture on depression compared with sham acupuncture (SA) or antidepressants (Fan et al., ; H. Wang et al., ); overall results have remained mixed and inconclusive (Leo & Ligot, ; Smith et al., ). Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Search strategies were developed using medical subject headings (MeSH) terms and keywords: acupuncture, acupuncture therapy, EA, LA, acupuncture point, acupoint, depression, depressive disorder, major depressive disorder, bipolar disorder, and dysthymic disorder. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Flowchart of literature selection on randomized controlled trials of acupuncture for depression. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 The efficacy of acupuncture for depression Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 The finding demonstrated that acupuncture could reduce the severity of depression, which is consistent with the Cochrane review (Smith et al., ). Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 This review has included the latest 22 RCTs published to October 2021, employing the quality assessment tool (Rob2) and providing updated evidence on using acupuncture to manage depression. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 However, the optimal types of acupuncture and ideal dosage when managing depression remain unanswered. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36509453 Acupuncture, either in isolation or as an adjunction to pharmacological treatment, has clinical benefits and could be considered a safe option for managing depression if qualified practitioners perform the intervention. Res Nurs Health. 2023 Feb;46(1):48-67. doi: 10.1002/nur.22284. Epub 2022 Dec 12. Depression Review
36532179 Acupuncture in treating cardiovascular disease complicated with depression: A systematic review and meta-analysis Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Cardiovascular Depression Review
36532179 Studies have shown that acupuncture has a positive effect on depression and CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 This systematic review and meta-analysis will evaluate the efficacy and safety of acupuncture in the treatment of depression complicated with CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 The result showed that acupuncture reduced the HAMD score [weighted mean difference (WMD): −3.23; 95% confidence interval (CI): −5.38 to −1.09; P = 0.003] and the SDS score (WMD: −1.85; 95% CI: −2.14 to −1.56; P < 0.00001) in patients with depression complicated with CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Acupuncture also improved the effective rate of depression (risk ratio: 1.15; 95% CI: 1.03 to 1.29; P = 0.01). Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 This article reviewed the significant advantages of acupuncture for depression and the superiority of acupuncture over no-intervention therapy, antidepressant therapy, and psychotherapy in reducing angina frequency and pain intensity in patients with CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 This systematic review suggested that acupuncture was a good complementary and alternative therapy for CVD complicated with depression. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 With the general recognition in the world, acupuncture has gradually become an important alternative therapy for depression. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Yet, the efficacy of acupuncture for CVD-related depression is unclear. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 We conducted this meta-analysis to investigate the efficacy and safety of acupuncture in treating depression complicated with CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Control trials may be sham acupuncture, standard care, antidepressants, and so on; (5) outcome measures in the trial must include an assessment of depression, like Clinical effective rate of depression, Hamilton scale for depression (HAMD), self-rating depression scale (SDS). Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Forest plot of safety profile and adverse events of acupuncture-treated CVD complicated with depression. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 A large body of evidence suggests that acupuncture has satisfactory efficacy and safety in the treatment of depression and CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Experiments in animal models of depression have shown that acupuncture increases hippocampal and neuroplasticity, reduces brain inflammation, and has effects on the HPA axis, neuropeptides, and neurotransmitters. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Many clinical studies have shown that acupuncture is good at relieving depression and improving cardiovascular symptoms, but it is unclear whether acupuncture can affect psycho-cardiology disease. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Cardiovascular Depression Review
36532179 Therefore, we designed this study to investigate the efficacy and safety of acupuncture in the treatment of depression complicated with CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Pooled data showed that acupuncture was more effective than no intervention in improving depression in patients with coronary heart disease. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 The result of this systematic review suggests that for CVD-related depression, acupuncture is a good complementary and alternative therapy under the premise of treating CVD. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 In terms of improving depression, the efficacy of acupuncture interventions was inconsistent in different subgroups. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36532179 Acupuncture was significantly better than no acupuncture for depression, but there was insufficient support that acupuncture was better than antidepressants in the treatment of depression. Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. Depression Review
36534008 Acupuncture added to other treatments, and manual acupressure were found to be effective in depression and stroke (very low- to low-quality evidence). Eur J Phys Rehabil Med. 2022 Dec;58(6):880-887. doi: 10.23736/S1973-9087.22.07813-3. Epub 2022 Dec 19. Depression Review
36570846 It was found that acupuncture effectively alleviates ANS dysfunction-associated symptoms in its indications, such as migraine, depression, insomnia, functional dyspepsia, functional constipation. Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. Insomnia Depression Review
36570846 Various lines of evidence have shown that acupuncture alleviates diseases and symptoms accompanied by autonomic disorders, such as migraine, depression, insomnia, functional dyspepsia, and constipation. Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. Insomnia Depression Review
36570846 According to a 2018 US survey, acupuncture is widely used to treat its indications of which the top 10 are lower back pain (LBP), depression, anxiety, headache, arthritis, allergy, systemic pain, female infertility, insomnia, and shoulder and neck pain, with pain ranking first among them. Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. Insomnia Anxiety Depression Review
36590284 Studies have shown that acupuncture can relieve pain, fatigue, hot flashes, anxiety and depression in cancer patients (Choi et al.,; Garcia et al.,; Posadzki et al.,). Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. Anxiety Depression Review
36601053 Acupuncture combined with fluoxetine treatment was more effective in the treatment of post-stroke depression at week 4, while rTMS combined with paroxetine was more effective at week 8. Front Pharmacol. 2022 Dec 19;13:1035895. doi: 10.3389/fphar.2022.1035895. eCollection 2022. Depression Review
36601053 Further research is needed to determine whether acupuncture combined with fluoxetine is better than rTMS combined with paroxetine for post-stroke depression at week 8. Front Pharmacol. 2022 Dec 19;13:1035895. doi: 10.3389/fphar.2022.1035895. eCollection 2022. Depression Review
36601053 According to our findings, acupuncture combined with fluoxetine treatment was more effective in the treatment of post-stroke depression at week 4 and had higher 50% HAMD improvement rate, while rTMS combined with paroxetine was more effective at week 8. Front Pharmacol. 2022 Dec 19;13:1035895. doi: 10.3389/fphar.2022.1035895. eCollection 2022. Depression Review
36601053 Further research is needed to determine whether acupuncture combined with fluoxetine is better than rTMS combined with paroxetine for post-stroke depression at week 8. Front Pharmacol. 2022 Dec 19;13:1035895. doi: 10.3389/fphar.2022.1035895. eCollection 2022. Depression Review
36620677 Acupuncture and related therapies for the anxiety and depression in irritable bowel syndrome with diarrhea (IBS-D): A network meta-analysis of randomized controlled trials Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 (1) Acupuncture-related therapies were used for intervention, but no indicators of anxiety and/or depression were reported; (2) Other types of IBS studies (such as IBS-C, IBS-M, IBS-U, among others); (3) The same group included three and more interventions; (4) Research with no clear original data reported and the author was not reachable; (5) similar research or reported the same results. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 Overall, MOX, ACU, and combined therapies had the highest benefit; (3) The ranking results revealed that MOX, ACU, combined therapies, and EA all had high SUCRA rankings for different outcome indicators, indicating that these interventions could serve as optimal interventions to improve anxiety and depression status in patients with IBS-D; (4) The results of adverse events depicted that the rate of adverse events was lower with acupuncture-related therapy than with drugs, establishing the safety of acupuncture-related therapy over pharmacotherapy. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 The NMA method utilized in this study can compensate for the lack of direct data by using indirect data which compares the efficacy of different acupuncture-related therapies against anxiety and depression status in patients with IBS-D. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 Meanwhile, we focused on the anxiety and depression status of IBS-D patients and selected suitable outcome indicators to evaluate the improvement of acupuncture-related therapies. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36620677 In recent years, increasing studies have confirmed the efficacy of acupuncture for various types of depression, and these studies suggest that acupuncture has great potential for the treatment of anxiety and depression. Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. Anxiety Depression Review
36684018 Electroacupuncture as a rapid-onset and safer complementary therapy for depression: A systematic review and meta-analysis Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36684018 Electroacupuncture (EA) is a promising therapy for depression. Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36684018 A review in 2018 exploring the overall efficacy of acupuncture (both EA and MA) on depression found weak evidence suggesting that the efficacy and safety of acupuncture was no less than that of antidepressants, and that acupuncture combined with antidepressants may have better efficacy than antidepressants alone. Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36684018 In brief, the key search terms were (electroacupuncture*) and (depression* or depressive disorder* or depressive disorder, major*). Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36684018 EA showed almost similar depression severity as the non-invasive acupuncture control [MD, 2.76; 95% CI, −5.66 to 11.18; 2 trials, 83 participants; Tau2 = 34.33; Chi2 = 13.95, df = 1 (P = 0.0002); Tau2 = 34.33; Chi2 = 13.95, df = 1 (P = 0.0002); I2 = 93%. Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36684018 A Cochrane meta-analysis of acupuncture (including EA) for depression (13 trials of EA) yielded low-quality evidence indicating that EA and EA + SSRIs reduce the severity of depression during and at the end of treatment more than SSRIs alone. Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36684018 Another meta-analysis of acupuncture for postpartum depression included four trials of EA; however, a meta-analysis for EA was not conducted because of insufficient data and trials. Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36684018 Another systematic review focused on the neuroimaging effects of acupuncture (including EA) in depression (10 trials of EA). Front Psychiatry. 2023 Jan 6;13:1012606. doi: 10.3389/fpsyt.2022.1012606. eCollection 2022. Depression Review
36704010 Pricking and cupping plus antiepileptics, are the most effective acupuncture-related techniques for pain relief, while EA plus antiepileptics is the best acupuncture-related technique for improving PHN-related insomnia and depression symptoms. Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. Pain Relief Insomnia Depression Review
36704010 Moreover, EA plus antiepileptics is the best acupuncture-related technique for improving PHN-related insomnia and depression symptoms. Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. Insomnia Depression Review
36760099 For high-risk patients, such as patients with chronic obstructive pulmonary disease or obstructive sleep apnea, the use of acupuncture is particularly valuable because these patients may have complications (mainly respiratory depression) due to use analgesics. Med Sci Monit. 2023 Feb 10;29:e938920. doi: 10.12659/MSM.938920. Depression Review
36852393 VA: verum acupuncture; SA: sham acupuncture; CBF: cerebral blood flow; ALFF: amplitude of low-frequency fluctuations; FC: functional connectivity; ReHo: regional homogeneity; ICA: independent components analysis; PET-CT: positron emission tomography-computed tomography; MRI: magnetic resonance imaging; fMRI: functional magnetic resonance imaging; PWI: perfusion-weighted imaging; ASL: arterial spin labeling; PPI: present pain intensity; PRI: pain rating index; STAI: state-trait anxiety inventory; BDI-II: beck depression inventory-II; MPQ: McGill pain questionnaire; NRS: numerical rating scale; CMSS: cox menstrual symptom scale; SAS: self-rating anxiety scale; SDS: self-rating depression scale; VAS: visual analog scale. Pain Res Manag. 2023 Feb 18;2023:8307249. doi: 10.1155/2023/8307249. eCollection 2023. Anxiety Depression Blood Flow Review
36925735 Acupuncture via NLRP3 inflammasome in the depression Front Neurosci. 2023 Feb 28;17:1118508. doi: 10.3389/fnins.2023.1118508. eCollection 2023. Depression Review
36925735 Subsequently, we analyzed how the inhibition of acupuncture on the activation of NLRP3 inflammasome alleviates depression. Front Neurosci. 2023 Feb 28;17:1118508. doi: 10.3389/fnins.2023.1118508. eCollection 2023. Depression Review
36925735 The above reports indicate acupuncture prevents CUMS-induced depression-like behaviors by reducing NLRP3-mediated pyroptosis and inflammatory responses. Front Neurosci. 2023 Feb 28;17:1118508. doi: 10.3389/fnins.2023.1118508. eCollection 2023. Depression Review
36925735 Since there are few studies involving acupuncture to regulate NLRP3 inflammasome in the treatment of other CNS diseases, our study only discusses five diseases, including AD, VD, depression, stroke, and SCI. Front Neurosci. 2023 Feb 28;17:1118508. doi: 10.3389/fnins.2023.1118508. eCollection 2023. Depression Review
36925735 In CNS diseases animal models, such as AD, VA, depression, stroke and SCI, acupuncture regulated the NLRP3 inflammasome activation with the characteristics of multiple targets, multiple links and multiple pathways. Front Neurosci. 2023 Feb 28;17:1118508. doi: 10.3389/fnins.2023.1118508. eCollection 2023. Depression Review
36930068 Yan Xueli et al used acupuncture (acupuncture of Si Shen Cong, an Mian, Shen Men, San Yin Jiao, Liver Yu, Lung Yu, Feng Chi, and Foot San Li) combined with Xiang Shu Tang (Xiang Shu, Chuan Xiong, Chai Hu, Qing Pi, Sour Jujube, and Hefei Pi) to treat 120 patients with perimenopausal insomnia of liver depression and qi stagnation, randomly and equally assigned into treatment and control groups. Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. Insomnia Depression Review
36950556 It can be seen that the covered groups with the need to treat cancer pain by acupuncture mainly existed in women, and their negative emotions were mainly anxiety and depression. Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. Cancer Pain Anxiety Depression Mood Review
36968497 Rather, clinical workers can understand IBS from a holistic bio-psycho-social model, which has the following five guiding implications for patients and researchers: (1) the combination of anti-anxiety and depression drugs can be used to treat irritable bowel syndrome in clinical work, providing a new way of thinking for the clinical treatment of the disease; (2) the treatment can be done from the perspective of treating the bowel from the brain; (3) acupuncture can be used to treat irritable bowel syndrome from the aspect of anxiety and depression; (4) keeping patients away from stressors to avoid long-term stimulation can be a treatment method; and (5) patients can be provided with stress training, psychological training, and positive meditation to prevent later relapse or frequent relapse. Front Neurosci. 2023 Mar 9;17:934341. doi: 10.3389/fnins.2023.934341. eCollection 2023. Anxiety Depression Review
36968499 In regard to the period from 2006 to 2010, the primary foci of the research were: (1) barostat testing, nutrient drink test, water load test, stool antigen test, 13C-octanoic acid breath test, gastric emptying scintigraphy, intraluminal electrical impedance, and electrogastrography; (2) H. pylori infection; (3) BMI and smoking; (4) GERD, hiatal hernia, atrophic gastritis, intestinal metaplasia, gastric adenocarcinoma, and duodenal ulcer; (5) duodenogastric reflux; (6) dysrhythmia; (7) gastric fundus tone, antroduodenal motility, impaired gastric accommodation, slow gastric emptying, and gastric acid secretion; (8) visceral hypersensitivity and visceral perception; (9) type 2 diabetes mellitus, insulin resistance, and impaired glucose tolerance; (10) metabolic syndrome; (11) chest pain, nausea, constipation, epigastric pain, heartburn, and gastric distension; (12) psychological factor, abuse history, and stress; (13) triple therapy, metronidazole, PPIs, baclofen, alosetron, atropine, prokinetic agent, serotonin reuptake inhibitor, psychotherapy, and nonsteroidal anti-inflammatory drug; (14) Mentha × piperita L., Glycyrrhiza glabra, Iberis amara, Matricaria recutita, Carum carvi, Chamomilla recutita, Chelidonium majus, caraway oil, Silybum marianum, Angelica archangelica, and STW5; (15) electrical stimulation and acupuncture; (16) diabetic gastroparesis and autonomic neuropathy; (17) stress, anxiety, and depression; (18) endocrine cell; (19) melatonin, leptin, 5-hydroxytryptamine (serotonin), and ghrelin; (20) cholecystokinin A receptor; (21) gut microbiota; (22) dietary fiber, gluten, high fat meal, lipid metabolism, and carbohydrate metabolism; (23) duodenal eosinophilia and oxidative stress; (24) antioxidant, arginine, nitric oxide, and glutathione; and (25) CagA and vacuolating cytotoxin. Front Neurosci. 2023 Mar 8;17:1109510. doi: 10.3389/fnins.2023.1109510. eCollection 2023. Endocrinology Nausea and Vomiting Anxiety Depression Review
37025199 Functional magnetic resonance imaging providing the brain effect mechanism of acupuncture and moxibustion treatment for depression Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 The efficacy of acupuncture and moxibustion in the treatment of depression has been fully recognized internationally. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 In recent years, some scholars have applied functional magnetic resonance imaging (fMRI) to study the central mechanism and the associated brain effects of acupuncture and moxibustion treatment for depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 The brain function networks associated with the acupuncture treatment of depression have not yet been adequately developed to provide a scientific and standardized mechanism of the effects of acupuncture. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 For this purpose, this study analyzes in-depth the clinical studies on the treatment of anxiety and depression by acupuncture and moxibustion, by depicting how the employment of fMRI technology provides significant imaging changes in the brain regions. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Anxiety Depression Review
37025199 However, a large number of clinical studies have reported that (i) long-term oral chemical prescription drugs can have debilitating anticholinergic side effects, resulting in poor patient compliance with the drugs and a high recurrence rate and (ii) on the contrary, acupuncture has good green clinical efficacy in the treatment of depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Side Effects Depression Review
37025199 With the rapid development of fMRI technology, acupuncture therapy combined with fMRI technology can observe, explore, and study the central mechanism of acupuncture in vivo and non-invasively, thereby providing a modern visual research means for acupuncture treatment of depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 In this study, clinical research on the treatment of depression by acupuncture and moxibustion and fMRI technology-based imaging changes in the brain regions are discussed in detail, providing the basis for future clinical research on the treatment of depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 These different methods of acupuncture and moxibustion to activate the brain, combined with fMRI brain imaging technology, provide the scientific basis for the further development of acupuncture to treat brain disorders associated with depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 This has provided a new scientific record of the brain effect mechanism of acupuncture, and it has laid out a theoretical foundation for the treatment of some mental diseases such as depression by hand acupuncture. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Changes of functional nuclei and brain areas under fMRI related to depression treated by acupuncture Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 In resting-state fMRI, it can be observed that the changes in the above parts of nuclear masses and brain regions are significant in people with depression, and acupuncture has a distinct influence on the changes of related nuclear masses and brain regions. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 The brain regions associated with depression that changed after acupuncture intervention are shown in Figure 3. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Brain regions associated with depression that changed with acupuncture intervention. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Existing studies have shown that electroacupuncture at the Baihui point can (i) regulate the default mode network in patients with depression and (ii) induce enhanced functional connectivity between the posterior central gyrus, the prefrontal cortex, and the bilateral ACC in patients with depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Some studies showed that the values of ALFF (amplitude of low-frequency fluctuations) of the left ACC/left medial orbital superior frontal gyrus and the left middle occipital gyrus/left angular gyrus decreased in patients with recurrent depression after auricular nail acupuncture treatment. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Studies have shown that both electroacupuncture and moxibustion can improve symptoms and relieve depression in patients with constipation-type irritable bowel syndrome, with electroacupuncture having a more significant effect than moxibustion; furthermore, it was observed by fMRI that the ALFF values of the ACC, insular cortex, and prefrontal cortex in patients decreased after treatment. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Electroacupuncture can induce (i) a decrease in functional connections between the amygdala and the orbitofrontal cortex in patients with depression and (ii) an increase in functional connections between the amygdala and the hippocampus, precuneus, anterior central gyrus, and angular gyrus in patients with depression, thus changing the abnormal amygdala network connections in patients with depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Acupuncture at the Hegu and Zusanli points can activate the hypothalamus and the nucleus accumbens and reduce the excitability of the pretuberous cortex, amygdala, and hippocampus; it can also activate the structure of the down-pass analgesic pathway and inactivate multiple limbic brain regions related to pain so as to achieve an analgesic effect and relieve patients' depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Analgesic Effect Depression Review
37025199 Electroacupuncture at the Baihui point can reduce the functional connections between the posterior central gyrus/prefrontal cortex and the left middle prefrontal cortex as well as between the left angular gyrus and the bilateral hippocampus/accessory hippocampus in patients with depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Existing studies have also shown that the functional connection between the hippocampus and ventral cephalic putamen in patients with depression under resting-state fMRI was significantly enhanced during acupuncture intervention. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Some studies have been conducted on patients with post-traumatic stress disorder accompanied by anxiety and depression, and the results showed that the patients' symptoms improved after electroacupuncture treatment. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Anxiety Depression Review
37025199 Therefore, it can be inferred that the improvement in anxiety and depression symptoms in post-traumatic stress disorder by electroacupuncture may be related to (i) the enhancement of connectivity between the parietal lobe and the hippocampus, and (ii) the inhibition of connectivity between the hippocampus, parahippocampal gyrus, and amygdala, leading to indirect effects on the limb system. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Anxiety Depression Review
37025199 Research has shown that the synthesis and release of serotonin neurotransmitter in the dorsal raphe nucleus can be regulated by electroacupuncture intervention for pain and depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Some studies have even used fMRI to show that acupuncture at the Taichong point can inhibit bilateral frontal lobes and most temporal lobes in patients with depression, and the change of the frontal lobe is likely to be one of the mechanisms of acupuncture in treating depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 After acupuncture treatment, the brain function of the prefrontal limbic region in patients with depression showed changes, and the functional connection between the right ventrocephalic putamen and the right dorsolateral prefrontal cortex as well as that between the bilateral cerebellar tonsil and the right dorsolateral caudate nucleus was reduced; thus, it was inferred that acupuncture could achieve therapeutic effects by regulating the prefrontal limbic region and the reward/excitation circuit of the striatum in patients with depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Compared with the control group, the functional connections between the ventral inferior striatum and the medial prefrontal cortex, between the ventral putamen and the amygdala/hippocampus, and between the dorsal caudal gyrus and the middle temporal gyrus were significantly enhanced in patients with depression after acupuncture treatment. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Current status of the brain functional network based on fMRI, providing the mechanism of acupuncture treatment of depression Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Acupuncture and moxibustion have become the main intervention measures for the treatment of depression because of their convenient operation, simple technique, obvious effect, and low price. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 However, the mechanism of the central effect of acupuncture and moxibustion on depression has not been scientifically explained. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 The emergence of fMRI technology provides an advanced means to explore the central mechanism of acupuncture and moxibustion through the brain functional network of people with depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 As far as the current research is concerned, it is generally believed that the default network in the functional network of the resting brain is closely related to the treatment of depression by acupuncture, which may be realized through the mutual integration of acupuncture information and depression information in the brain; however, this still needs to be further explored. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 treated patients with depression for 8 weeks using the acupuncture method of smoothing the liver and strengthening the spleen, and the results showed that the resting-state fMRI data had significant changes, and that regulation of the thalamic-cingulate gyrus-parahippocampal gyrus-frontal neural pathway was the basis for the regulation of neural information in the brain in the treatment of depression by acupuncture. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Table 2 summarizes the research methods and findings of different research groups on acupuncture treatment for depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 used electroacupuncture at the Yinang and Baihui points for the treatment of mild and moderate primary depression, with fMRI used to determine the resting-state ALFF data and ReHo data of patients with depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Acupuncture and moxibustion in the treatment of depression relieve depression and soothe the patient, which can promote emotional stability and peace of mind both physically and psychologically. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Mood Review
37025199 On the one hand, in the treatment of depression, the brain's functional network of acupuncture and moxibustion plays a potential regulatory role. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 On the other hand, the objective proof of fMRI provides an effective verification of the brain effect mechanism of acupuncture and moxibustion in the treatment of depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Therefore, future studies can explore the integration and regulation effects of acupuncture on depression-related brain functional networks. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 In recent years, fMRI technology has been gradually applied in the study of the brain effect mechanism of acupuncture for depression, functional dyspepsia, facial palsy, stroke, and other diseases, and it has made phased progress in clinical practice. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Studies have shown that electroacupuncture stimulation of the auricular thyroid vagus nerve can effectively treat mild to moderate depression in clinical practice, and its mechanism is regulation of the functional state of the vagus nerve, so as to change the emotion control center in the brain. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Mood Review
37025199 It is a very challenging task to introduce fMRI technology into the study of acupuncture treatment of depression and to provide an fMRI image basis for the brain functional network. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 At present, fMRI studies on acupuncture for depression are limited to single or several independent brain functional networks related to depression, but they lack observation of the integration effect among brain functional networks. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 However, there are few relevant studies that observe the changes of the amygdala and the dorsal raphe nucleus in patients with depression before and after acupuncture treatment using fMRI. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025199 Therefore, further research is needed on the neural circuits through which acupuncture can treat depression. Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. Depression Review
37025378 Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 In this article, we reviewed the studies on changing intestinal microbiota after acupuncture treatment and examined the existing problems and development prospects of acupuncture, microbiome, and poststroke depression, in order to provide new ideas for future acupuncture research. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 The mechanism of intestinal microbiota dysbiosis induced by post-stroke depression (PSD) and how acupuncture regulates the intestinal microbiota to treat PSD. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 Recent studies have gradually shown that acupuncture indirectly alters the microbial composition and communities in various ways, and researchers have found that post-stroke depression-like behavior is strongly associated with intestinal microbial changes after acupuncture treatment. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 A manual acupuncture treatment was conducted on rats with depression by, and researchers found that manual acupuncture regulation could reduce Bacteroides/Firmicutes ratios in the intestinal tract of depressed rats and improve the biodiversity of intestinal flora. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 As a result of correlation analysis of differential microflora and differential metabolites, the authors speculated that the changes of microflora caused by manual acupuncture will affect the changes in serum metabolites, and integrating acupuncture into the process of regulating depression. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 After Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, it was found that manual acupuncture affected the cell growth, the apoptosis pathway, the cofactor and vitamin metabolism pathway, amino acid metabolism pathway, and the carbohydrate metabolism pathway in rats, as well as improving their depression-like behavior through the brain-gut axis. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 In addition, there is evidence that VIP can improve the immunity of intestinal mucosa, and it is also associated with biological depression, thus, acupuncture may be a mediator of gut-brain communication. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Immunity Depression Review
37025378 conducted manual acupuncture treatment on depressed rats and they found that acupuncture regulates gut microbes and neurotransmitters to alleviate depression-like manifestations in rats. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 From the current development perspective of acupuncture in the treatment of PSD, the mechanism of acupuncture to maintain the dynamic balance between the type and number of intestinal flora to treat and prevent depression has not been thoroughly studied. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Depression Review
37025378 The future should involve more researches to explore whether acupuncture can restore ecological balance of intestinal microbes in the immune deficiency model of depression to improve depression, and determine the causal relationship among the three to fill the gaps in current knowledge. Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. Immunity Depression Review
37034090 Effect of acupuncture combined with antidepressants on post-stroke depression: A network meta-analysis of nine acupuncture therapy Front Neurol. 2023 Mar 23;14:979643. doi: 10.3389/fneur.2023.979643. eCollection 2023. Depression Review
37034090 (A) Total effective rate; (B) Hamilton Depression Scale score; (C) Self-Rating Depression Scale score; (D) National Institutes of Health Stroke Scale score; (A) antidepressants; (B) wrist-ankle acupuncture plus antidepressants; (C) moxibustion plus antidepressants; (D) electroacupuncture plus antidepressants; (E) conventional acupuncture plus antidepressants; (F) auricular electroacupuncture plus antidepressants; (G) auricular pressure plus antidepressants; (H) acupressure plus antidepressants; (I) abdominal acupuncture plus antidepressants; (J) eye acupuncture plus antidepressants. Front Neurol. 2023 Mar 23;14:979643. doi: 10.3389/fneur.2023.979643. eCollection 2023. Depression Review
37034090 (A) Total effective rate; (B) Hamilton Depression Scale score; (C) Self-Rating Depression Scale score; (D) National Institutes of Health Stroke Scale score; (A) antidepressants; (B) wrist-ankle acupuncture plus antidepressants; (C) moxibustion plus antidepressants; (D) electroacupuncture plus antidepressants; (E) conventional acupuncture plus antidepressants; (F) auricular electroacupuncture plus antidepressants; (G) auricular pressure plus antidepressants; (H) acupressure plus antidepressants; (I) abdominal acupuncture plus antidepressants; (J),eye acupuncture plus antidepressants. Front Neurol. 2023 Mar 23;14:979643. doi: 10.3389/fneur.2023.979643. eCollection 2023. Depression Review
37046882 In situations where death by suicide is a major global issue and effective prevention and management approaches are lacking, acupuncture improves some risk factors for suicide, including depression, and it has been used for a long time in clinical settings. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Depression Review
37046882 Acupuncture was effective in direct and indirect outcomes related to suicidal behavior, not only for participants with suicidal behavior, but also for those with other conditions, including depression. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Depression Review
37046882 Acupuncture has been shown to have therapeutic benefits for the known risk factors for suicidal behaviors, including depression, PTSD, and chronic pain. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Depression Review
37046882 performed manual acupuncture for a total of 44 sessions over 3 months for patients (n = 21) with depression and suicidal ideation and found that the effective rate, defined as the reduction rate of HAMD, reached 90.48% (19/21). Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Depression Review
37046882 In the three-arm RCT by Li et al., patients with post-stroke depression were randomly divided into auricular acupuncture using a magnet piece group (group A, n = 31), auricular acupuncture by a vaccaria seed group (group B, n = 31), and a control group (group C, n = 31). Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Depression Review
37046882 Among the four studies of acupuncture on participants with depression, but suicidal behavior is not a mandatory inclusion criterion, electro-acupuncture was used in three studies. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Depression Review
37046882 If quantitative accumulation on this topic is premised in the future, it may be possible to investigate the effectiveness of acupuncture on suicidal behavior in specific clinical conditions, such as major depression. Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. Depression Review
37091130 The efficacy of acupuncture in treating depression through regulating 5-HT levels has been demonstrated. Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. Depression Review
37143014 Acupuncture for post-stroke depression: a systematic review and network meta-analysis BMC Psychiatry. 2023 May 4;23(1):314. doi: 10.1186/s12888-023-04749-1. Depression Review
37143014 Acupuncture (AC), as a minimally invasive technique, has become a popular choice for improving depression symptoms. BMC Psychiatry. 2023 May 4;23(1):314. doi: 10.1186/s12888-023-04749-1. Depression Review
37187857 It is informative to describe in some detail the different approaches to pain management in the homeless and precariously housed population, such as (CBD) pills, acupuncture, and accelerated resolution therapy (ART), which examines individual's trauma to address pain, as well as depression (see below). Front Pain Res (Lausanne). 2023 Apr 28;4:1020038. doi: 10.3389/fpain.2023.1020038. eCollection 2023. Depression Review
37200784 Moreover, animal studies have shown that acupuncture treatment can reduce anxiety, depression, and fear responses; improve sleep architecture; reduce spatial learning and memory deficits; and ultimately improve PTSD (Kwon et al.,). Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Learning and Memory Ability Anxiety Depression Review
37200784 Dizziness, headache, nausea, vomiting, tachycardia, trembling hands, fatigue, depression, decreased appetite, decreased libido, lethargy or insomnia, excessive sedation or agitation, diarrhea or constipation, dry eyes or blurred vision, nasal congestion, and skin irritation were reported in the non-acupuncture group. Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Insomnia Nausea and Vomiting Depression Sedation Review
37200784 Another study revealed that IL-6 levels were inversely related to cognitive levels (Gruol,), and acupuncture could reduce IL-6 levels in the PFC (Chen et al.,) and reduce anxiety and depression in PTSD model animals. Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. Anxiety Depression Review
37289799 In the study involving patients with depression, warming-promotion acupuncture for 1 month promoted significant better total cure rates and HAMD scores compared to regular acupuncture or psychotherapy (Table 1). PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Depression Review
37289799 (2020), which evaluated the quality of life among participants, found that acupuncture significantly improved some aspects of the EQ-5D, including mobility and pain/discomfort, but not self-care, usual activities, and anxiety/depression. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Anxiety Depression Review
37289799 Although PTSD is a common mental health problem after earthquakes, we believe that anxiety and depressive disorders among earthquake survivors may be understudied areas in acupuncture research considering the similarly high prevalence of depression and anxiety. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Anxiety Depression Review
37289799 Thus far, scalp electro-acupuncture has been reported to have beneficial effects on various neuropsychiatric diseases, including vascular dementia, autism, stroke, post-stroke depression, and MDD. PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. Depression Review
37396891 The inclusion criteria were as follows: (1) participants: patients ≥ 18 years old who met the requirements of gastrointestinal endoscopy; (2) interventions: manual acupuncture or electroacupuncture (without limiting the acupuncture points, manipulations, or depth) performed before or during gastrointestinal endoscopy with propofol as the main sedative; (3) control: placebo, sham acupuncture, or no additional treatment, with the same sedative (s) as in the intervention group; (4) outcomes: sedative consumption as the primary outcome, and the incidence of adverse events (defined as respiratory depression/bradycardia/hypotension/hypoxemia/nausea or vomiting/abdominal distension/dizziness/coughing/restlessness during or after gastrointestinal endoscopy) and wake-up time (from the end of the examination to the time when patients can correctly answer basic questions) as the secondary outcomes; (5) study design: randomized controlled trials (RCTs). Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. Nausea and Vomiting Depression Review
37405111 With respect to psychological balance, acupuncture studies have been designed to relieve anxiety and depression through the regulation of circulating β-endorphins and androgens in patients with PCOS. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Depression Circulation Review
37405111 Studies 2 and 6 attended to the effect of acupuncture as a method to relieve the anxiety of women with PCOS with fertility issues and to manage anxiety and depression symptoms in unmarried women with PCOS, respectively. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Depression Review
37405111 Considering the aforementioned information, it is possible to justify the confirmed correlation between the reduction of anxiety and depression scores in women submitted to acupuncture intervention in study 6 with a physiological decrease in serotonin and gamma-aminobutyric acid (GABA), and the increase of norepinephrine after active acupuncture treatment. J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. Anxiety Depression Review
37441610 Acupuncture can be used as a single intervention or in combination with other treatments, which is recommended for the treatment of stroke-related sequelae, such as hemiplegia, shoulder-hand syndrome, depression, post-stroke spasticity, and constipation. Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. Depression Review
37441610 Third, acupuncture can improve sleep quality and has long-term efficiency; moreover, it can also relieve other stroke sequelae such as depression to avoid aggravating insomnia. Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. Insomnia Depression Sleep Quality Review
37467569 The integration of Ayurveda management, including Panchakarmatherapy and Ayurveda medications, with other alternative therapies like Acupuncture, Yoga, and Rehabilitation improved muscle strength, quality of life, range of motion, and neuronal function, and reduced depression, stress, and pain with symptom scores. J Ayurveda Integr Med. 2023 Jul-Aug;14(4):100749. doi: 10.1016/j.jaim.2023.100749. Epub 2023 Jul 17. Depression Review
37501979 Further high-quality RCTs following standardized guidelines with a low risk of bias are needed to confirm the effectiveness of acupuncture for postpartum depression. Heliyon. 2023 Jul 11;9(7):e18157. doi: 10.1016/j.heliyon.2023.e18157. eCollection 2023 Jul. Depression Review
37501979 However, scalp acupuncture is a specialized technique that involves the insertion of needles into specific zones on the scalp that correspond to different regions of the brain, making it more effective at treating certain neurological and psychiatric conditions, such as stroke, Parkinson's disease, and depression, than acupuncture at specific points on the head. Heliyon. 2023 Jul 11;9(7):e18157. doi: 10.1016/j.heliyon.2023.e18157. eCollection 2023 Jul. Depression Review
37505150 Finally, it was found that the acupuncture method of regulating mind combined with Bushen Huoxue Shugan Decoction could improve the clinical symptoms of PD patients with depression, and the curative effect was exact, at the same time, it could reduce the inflammatory reaction and promote the recovery of cognitive function, which was safe and reliable. Medicine (Baltimore). 2023 Jul 28;102(30):e34278. doi: 10.1097/MD.0000000000034278. Cognitive Function Depression Review
37510483 Our results showed that acupuncture improved PD-related sleep disorders and depression but had no effect on anxiety and fatigue. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 Our meta-analysis suggests that acupuncture can be used as a complementary treatment for sleep disturbances and depression in PD patients and may exhibit a dual therapeutic effect on motor and non-motor symptoms. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Insomnia Depression Review
37510483 Overall, our study highlights the potential of acupuncture as a viable complementary therapy for the treatment of PD non-motor symptoms of sleep disorders and depression, which can improve the quality of life of PD patients. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 While acupuncture is a popular alternative therapy for PD patients that has been shown to improve motor symptoms, its efficacy in treating non-motor symptoms, such as sleep disorders, depression, anxiety, and fatigue, remains controversial. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 Some studies suggest that acupuncture can improve sleep efficiency, depression, and anxiety in PD patients. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 A meta-analysis of 27 randomized controlled trials suggests that acupuncture treatment could ameliorate the symptoms of depression, quality of life, cognition, total mentation, behavior and mood, and activities of daily living in PD patients. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Mood Review
37510483 The primary endpoint of our study is the effect of acupuncture on sleep quality, while the secondary endpoints are its impact on depression, anxiety, and fatigue. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Sleep Quality Review
37510483 On the other hand, the level of certainty for depression outcomes was moderate, indicating consistent evidence in favor of acupuncture treatment and precise outcomes. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 The Secondary Outcome of Acupuncture in Depression Improvement Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 Nine studies with a total of 457 participants were analyzed, and the results indicated a significant difference with no substantial heterogeneity between acupuncture and the control group, suggesting that acupuncture significantly improved depression (SMD = 0.242; 95% CI: 0.055 to 0.430; p = 0.011; I2 = 0%) (Figure 3A). Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 A further analysis was conducted on the effect of different control groups (no acupuncture or sham), and it was found that acupuncture significantly improved depression in PD patients compared to no acupuncture (SMD = 0.311; 95% CI: 0.076 to 0.545; p = 0.009; I2 = 0%). Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 Nevertheless, compared to sham acupuncture, acupuncture did not improve depression in PD patients (SMD = 0.121; 95% CI: −0.192 to 0.435; p = 0.448; I2 = 0%). Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 These findings suggest that acupuncture, acupuncture/bee venom, or electroacupuncture may have a small effect on improving depression in PD patients compared to no acupuncture, and sham acupuncture may have a placebo effect on depression. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 Acupuncture was found to have a small effect on depression, while showing no significant improvements in anxiety and fatigue in PD patients compared to the control group. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 The differential effectiveness of acupuncture on sleep and depression, as compared to anxiety and fatigue, may be attributed to the specific utilization of electroacupuncture for PD-related sleep and depression, while its application for anxiety and fatigue was not explored. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Anxiety Depression Review
37510483 A recent meta-analysis found that combining acupuncture with medication may be more effective in improving PD-related insomnia and depression than medication alone. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Insomnia Depression Review
37510483 In conclusion, our results support the use of acupuncture to improve PD-related sleep disorders and depression, but further research is necessary to investigate the potential interplay between acupuncture, sham acupuncture, and PD medication. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 However, the results of our meta-regression analysis revealed that age and gender did not demonstrate statistically significant impacts on the outcomes of acupuncture in PD-related sleep disorders and depression. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 In summary, our meta-analysis has demonstrated that acupuncture can be an effective treatment option for non-motor symptoms of sleep disorders and depression in PD patients. Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37510483 (B) Subgroup analysis of the effect of acupuncture intervention on depression based on different control groups (sham acupuncture or no acupuncture). Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. Depression Review
37542321 The present results suggest that, compared with Western medicine and sham acupuncture, acupuncture seems to be able to effectively improve anxiety and depression in migraine patients.And it may be more effective in improving SF36-mental health, VAS and MSQ than shame acupuncture or Western medicine. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Review
37542321 In addition, acupuncture can effectively relieve migraine, adjust the mental and psychological state of patients and improve the depression/anxiety disorder of migraine patients. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Review
37542321 Although there is evidence that acupuncture can prevent and relieve migraine and concomitant symptoms such as depression and sleep disturbances, several long-term follow-ups of high-quality RCTs indicate that acupuncture improves the frequency of migraine attacks and the length of the headache, but do not specify whether the long-term follow-up after treatment could improve the mental health of patients; therefore, the long-term effectiveness of acupuncture in improving mental health in migraine patients is unclear. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Insomnia Depression Review
37542321 Since the purpose of this study was to investigate the effects of acupuncture on anxiety, depression and other emotional disorders in migraine patients, the main outcome indicators such as Pain-Related Mood Disorders (Zung Self-Rated Anxiety Scale (SAS), Zung Self-rating Depression Scale (SDS) and Short Form 36 Mental Health (MH) that can better reflect the improvement of mood were selected as the main outcome indicators. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Mood Review
37542321 The present results suggest that, compared with Western medicine and sham acupuncture, acupuncture seems to be able to effectively improve anxiety and depression in migraine patients. BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. Anxiety Depression Review
37543780 Efficacy and safety of scalp acupuncture for poststroke depression: A meta-analysis and systematic review Medicine (Baltimore). 2023 Aug 4;102(31):e34561. doi: 10.1097/MD.0000000000034561. Depression Review
37543780 Scalp acupuncture (SA), one of the acupuncture techniques, combines traditional meridian and collateral theory with modern cerebral cortex functional positioning areas and has greater efficacy in the treatment of brain-derived diseases, simultaneously relieving the symptoms of depression and neurological deficits in patients. Medicine (Baltimore). 2023 Aug 4;102(31):e34561. doi: 10.1097/MD.0000000000034561. Depression Review
37543780 These findings suggest that traditional Chinese medicine techniques, particularly scalp acupuncture, may hold promise as a potential treatment for depression in poststroke patients, and further research in this area is warranted. Medicine (Baltimore). 2023 Aug 4;102(31):e34561. doi: 10.1097/MD.0000000000034561. Depression Review
37543780 The aforementioned evidence implies that scalp acupuncture may confer more substantial improvements to depression and neurological function in PSD patients, with superior safety and definite clinical efficacy, compared to western medical treatments. Medicine (Baltimore). 2023 Aug 4;102(31):e34561. doi: 10.1097/MD.0000000000034561. Depression Review
37546517 Targeting Mitochondrial Homeostasis: The Role of Acupuncture in Depression Treatment Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 In this article, we focus on the core link of depression-mitochondrial homeostasis and summarize the research progress of acupuncture targeting mitochondrial homeostasis in the treatment of depression in recent years, so as to provide ideas and experimental basis for the research and formulation of more appropriate depression treatment strategies. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Acupuncture has been found to regulate mitochondrial homeostasis (by modulating mitochondrial autophagy, reducing mitochondrial oxidative stress, inhibiting mitochondrial fission, inducing mitochondrial biogenesis, and maintaining mitochondrial dynamics), alleviate depression-like behavior, and regulate signal pathways and key proteins. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Here, we highlight the role of acupuncture in the treatment of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 A comprehensive exploration of the impact of acupuncture on mitochondrial homeostasis could potentially present a novel mechanism for treating depression and offer fresh perspectives for the treatment of patients with clinical depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 As a non-drug therapy, acupuncture has great potential in the treatment of depression and can replace or assist drug therapy to improve the curative effect. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 As early as 1984, a study confirmed that acupuncture has a unique therapeutic effect on depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 The report shows that the overall efficacy of various acupuncture methods in the treatment of depression after 6 weeks is about 70% to 83.7%, which is equivalent to or even higher than that of antidepressant western drugs. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 The results of Meta-analysis showed that acupuncture could significantly reduce the degree of depression compared to the routine treatment group, the sham acupuncture group, and the antidepressant treatment group, and there was a significant correlation between the increase in acupuncture treatment times and the decrease in severity of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 The latest research has proved that acupuncture can treat depression in many ways (Table 1). Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 New research has shown that acupuncture can treat depression in a variety of ways, including targeting mitochondrial homeostasis. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Therefore, this paper reviews the related research in order to clarify the new mechanism of acupuncture in the treatment of depression: targeting mitochondrial homeostasis and providing a new strategy for the treatment of patients with depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 However, although the mitophagy of depression has been well studied and a certain number of acupuncture and mitophagy studies have been published, the comprehensive study on the effect of acupuncture on mitophagy of depression is still limited. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Previous studies have shown that acupuncture improves depression-like behavior in CUMS rats, which is associated with oxidative stress in the hippocampus. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Acupuncture has become a common complementary and alternative treatment of depression, an animal experiment in the OVX-induced depression rat model, showed that acupuncture can relieve oxidative stress in the amygdala, change in oxidative stress-related protein (8 - OHDG, BJP, pJNK), play a significant antidepressant effect. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Therefore, an in-depth study of the exact mechanism of acupuncture stimulation of the antidepressant effect by inhibiting oxidation is particularly important for the treatment of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Further study on the exact mechanism of mitochondrial biogenesis induced by acupuncture is helpful to solve the difficult problem of depression treatment. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 The research on acupuncture-mitochondrial dynamics-depression is still shallow, and in-depth research on the exact mechanism of acupuncture regulating mitochondrial dynamics may provide new ideas for the treatment of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Acupuncture can interfere with neuroplasticity in many ways so as to assist the treatment of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 In addition, acupuncture can promote the growth and regeneration of nerve cells, which is very important in restoring neurological function and improving symptoms of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Acupuncture can improve the symptoms of depression by regulating the function of the immune system and reducing the inflammatory response. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Immunity Depression Review
37546517 In summary, acupuncture can affect neuroplasticity through many mechanisms and improve symptoms of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Currently, there are no human studies to support our proposed mechanism of acupuncture in the treatment of depression by regulating mitochondrial homeostasis. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 It is found that acupuncture can regulate mitochondrial homeostasis (regulate mitochondrial autophagy, reduce mitochondrial oxidative stress, inhibit mitoptosis, induce mitochondrial biogenesis, and maintain mitochondrial dynamics), reduce depression-like behavior, regulate signal pathways and key proteins. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 However, the exact mechanism and relationship of acupuncture in the treatment of depression by regulating mitochondrial homeostasis is not clear. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546517 Therefore, in-depth study of acupuncture targeting mitochondrial homeostasis may be a new mechanism for the treatment of depression and provide new ideas for the treatment of patients with clinical depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. Depression Review
37546518 Effects of Music, Massage, Exercise, or Acupuncture in the Treatment of Depression Among College Students: A Network Meta-Analysis Neuropsychiatr Dis Treat. 2023 Aug 1;19:1725-1739. doi: 10.2147/NDT.S416643. eCollection 2023. Depression Review
37546518 Non-drug treatment methods for depression are currently exercise intervention, music intervention, meditation, acupuncture, massage, and so on. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1725-1739. doi: 10.2147/NDT.S416643. eCollection 2023. Depression Review
37546518 Music, massage, and acupuncture have also been proven to be effective in the treatment of depression. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1725-1739. doi: 10.2147/NDT.S416643. eCollection 2023. Depression Review
37546518 Therefore, four interventions (exercise, music, massage, and acupuncture) that are regularly utilized in the treatment of depression among college students were selected as research objects. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1725-1739. doi: 10.2147/NDT.S416643. eCollection 2023. Depression Review
37546518 It is important to note that the study focused on undergraduate students, excluding high school students; (2) experimental interventions related to exercise, music, massage, and acupuncture; (3) the outcome indicators were the depression scores assessed by the scale, and the before and after indicators were reported in detail, such as mean, standard deviation, sample size, etc. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1725-1739. doi: 10.2147/NDT.S416643. eCollection 2023. Depression Review
37546518 For example, there is only one paper on massage, which makes objectively explaining its intervention impact on college students with depression difficult, and the acupuncture therapy included in the pre-search was rejected during literature screening, which is regrettable. Neuropsychiatr Dis Treat. 2023 Aug 1;19:1725-1739. doi: 10.2147/NDT.S416643. eCollection 2023. Depression Review
37568485 Likewise, the reduction of constipation seemed to correlate with reductions in anxiety and depressive mood, as recorded with HADS after massages and aerobic and resistance training, and the self-rating anxiety scale and self-rating depression scale after electro-acupuncture stimulation at the Tiensu point. J Clin Med. 2023 Aug 2;12(15):5083. doi: 10.3390/jcm12155083. Anxiety Depression Mood Review
37568485 The self rating anxiety scale and the self-rating depression scale were used for electro-acupuncture stimulation. J Clin Med. 2023 Aug 2;12(15):5083. doi: 10.3390/jcm12155083. Anxiety Depression Review
37614343 Acupuncture therapy, which has beneficial effects on neuroprotection, has been shown to improve serum and hippocampal 5-HT and DA levels in depression model rats. Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. Neuroprotection Depression Review
37614513 Acupuncture for tumor-related depression: a systematic review and meta-analysis Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Acupuncture is extensively used to treat tumor-related depression, but the effect of body acupuncture on tumor-related depression is still unsubstantiated. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 This work, therefore, set out to assess the effect of acupuncture on tumor-related depression. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Meta-analysis revealed that acupuncture had a beneficial effect compared with usual care on the Hamilton depression scale (HAMD) (mean difference (MD) = −2.23, 95% CI [−4.43, −0.03], p = 0.05), self-rating depression scale (SDS) (MD= −6.22, 95% CI [−10.67, −1.78], p = 0.006), effective rate (RR = 1.23, 95% CI [1.06, 1.43], p = 0.006), and quality-of-life questionnaire (QLQ-C30) (MD = 6.08, 95% CI [3.72, 8.43], p<0.0001). Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Acupuncture is a safe and effective complementary therapy for tumor-related depression. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 A retrospective study described that acupuncture was as effective as medication for cancer-related depression. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 However, there were still some studies that argued that acupuncture failed to improve the relevant scale of tumor-related depression better than usual care, like HAMD or SDS. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Accordingly, the effect of acupuncture on tumor-related depression was controversial. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Only one review assessed the effect of acupuncture and acupressure on tumor-related depression. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Acupuncture (including body acupuncture and electroacupuncture) used as an intervention to treat tumor-related depression was covered. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Moreover, it took at least one month for acupuncture to exert effects on tumor-related depression. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Acupuncture plus usual care was applied to the treatment group in one study, and the result indicated that acupuncture plus usual care had a superior effect on tumor-related depression compared to just usual care. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 The interventions were different, so the results of two studies were synthesized to assess the efficacy of acupuncture for tumor-related depression patients. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Every study proved the favorable effects of acupuncture for tumor-related depression compared to usual care. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 A previous study had implied that acupuncture may ameliorate emotional depression by strengthening hippocampal neuroplasticity and attenuating inflammation in the brain. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Mood Review
37614513 One experiment found that acupuncture prevents the occurrence of depression by regulating the HPA axis. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Our work provides updated evidence to inspect the effect and safety of conventional acupuncture for cancer tumor-related depression. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Unfortunately, we were confined to conducting a subgroup analysis to determine the effect of different acupuncture regimens on tumor-related depression because few articles were available. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Acupuncture stimulation at GV20 and GV24+ could prevent and treat depression by modulating the expression of multiple neurotrophic factors. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Acupuncture stimulation at HT7 can ameliorate depression in rat models by increasing 5-HT expression and BDNF levels. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Though a multitude of studies did not take the efficacy of acupuncture as an observation index, relevant depression scales were put into use, indicating that a state of depression was prevalent in tumor patients. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Although the conclusions indicated the effectiveness and safety of acupuncture, the effect of conventional acupuncture on tumor-related depression alone was lacking. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 Acupuncture is effective and safe to manage tumor-related depression and should be considered a complementary therapy for tumor-related depression patients. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37614513 More RCTs with rigorous designs and larger sample sizes are indispensable to verifying the effect of acupuncture on depression patients diagnosed with tumors. Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. Depression Review
37629744 A meta-analysis demonstrated that acupuncture-related therapies showed inefficacy in improving depressive symptoms in PD patients; another one showed that it was effective in alleviating depression in PD and a 2-month course was found to represent the optimal intervention duration. Medicina (Kaunas). 2023 Aug 12;59(8):1454. doi: 10.3390/medicina59081454. Depression Review
37629744 Hence, acupuncture may represent an effective complementary treatment approach for PD depression; although, the optimal methods and techniques for this population need further investigation. Medicina (Kaunas). 2023 Aug 12;59(8):1454. doi: 10.3390/medicina59081454. Depression Review
37637184 This has confirmed that acupuncture-related therapies can reduce symptoms such as depression and anxiety in patients with opioid dependence, and effectively reduce patients' methadone doses. Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Depression Review
37637184 Significant evidence of efficacy was observed in the acupuncture group in improving anxiety, depression, sleep disorders, and somatic symptoms, compared to that in the control group. Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Anxiety Depression Review
37637184 Finally, previous reviews have shown that acupuncture can be effective in treating opioid use disorder; EA can alleviate cravings for opioids and depression, and TEAS can mitigate symptoms of insomnia and anxiety. Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. Insomnia Anxiety Depression Review
37678839 Thus, acupuncture can relieve pain and related depression by regulating TPRV1 expressions in different brain regions. Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. Depression Review
37678839 From an intermediate neuron perspective, acupuncture relieves pain by up regulating GABAergic intermediate neurons in ACC and also relieves pain-related anxiety as well as depression. Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. Anxiety Depression Review
37732301 Acupuncture at Baihui (GV20) and DU29 effectively counteract the chronic stress-induced down-regulation of BDNF mRNA and protein expression in the frontal cortex and hippocampus of rat models of depression. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Depression Review
37732301 Acupuncture improves depression and anxiety symptoms by modulating the HPA axis. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37732301 Through the modulation of these factors, acupuncture can potentially alleviate IBS-related depression, anxiety, and VH symptoms. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37732301 The regulation of the HPA axis by acupuncture has been extensively reported, however, limited studies have demonstrated whether acupuncture by regulating the HPA axis can improve the VH induced by depression and anxiety in IBS. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37732301 A few studies have shifted their focus toward investigating whether acupuncture and moxibustion alleviate depression and anxiety by targeting the HPA axis, subsequently mitigating VH exacerbation. Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. Anxiety Depression Review
37760483 Considering psychological patient-reported outcomes, no significant effects were reported in meta-analyses assessing the effect of acupuncture on anxiety, depression and cognitive function. Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. Cognitive Function Anxiety Depression Review
37780709 In addition, homeostatic plasticity of BDNF in the hippocampus may be related to the mechanism of acupuncture in the treatment of depression. Front Neurol. 2023 Sep 14;14:1248348. doi: 10.3389/fneur.2023.1248348. eCollection 2023. Depression Review
37780709 Acupuncture appears to have a significant effect on the emergence of depression by boosting the production of the plasticity protein BDNF. Front Neurol. 2023 Sep 14;14:1248348. doi: 10.3389/fneur.2023.1248348. eCollection 2023. Depression Review
37810368 Acupuncture treatment can inhibit immune inflammatory reactions, neuroinflammatory reactions, oxidative stress levels, and hypothalamus-pituitary-adrenal (HPA) axis activity, improve lung function, and relieve migraine, fatigue, anxiety, and depression. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Anxiety Depression Review
37810368 Other studies found that acupuncture treatment can inhibit immune inflammatory reactions, neuroinflammatory reactions, oxidative stress levels, and hypothalamus-pituitary-adrenal (HPA) axis activity; improve lung function, and relieve migraine, fatigue, anxiety, and depression.However, whether acupuncture treatment is suitable for the treatment of these symptoms in patients with COVID-19 still needs to be investigated. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Anxiety Depression Review
37810368 The clinical practice guidelines for non-drug treatment and drug treatment of adult patients with major depression developed by the American College of Physicians in 2016 suggested that acupuncture treatment for major depression has fewer adverse reactions than drug treatment. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Adverse Reactions Depression Review
37810368 In 2018, ASCO proposed that acupuncture can be used to improve emotional disorders, anxiety, and depression in patients with breast cancer (level C). Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Anxiety Depression Mood Review
37810368 Several meta-analyses have shown that acupuncture can effectively relieve anxiety and depression in patients and that it is very safe. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Anxiety Depression Review
37810368 Acupuncture can play a role in relieving anxiety and depression and promoting sleep by regulating neurotransmitters, immune inflammatory reactions, and HPA axis activity. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Anxiety Depression Review
37810368 EA can reduce the concentration of corticotropin-releasing hormones (CRH) in the hypothalamus and pituitary, as well as the concentrations of CRH, adrenocorticotropic hormone (ACTH), and cortisol (CORT) in the serum, indicating that acupuncture can relieve anxiety, depression, and sleep difficulties by inhibiting the activity of the HPA axis. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Anxiety Depression Review
37810368 Moreover, acupuncture regulates neurotransmitter release, immune inflammatory reactions, and HPA axis activity to improve anxiety, depression, and insomnia. Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. Immunity Insomnia Anxiety Depression Review
37893778 Previous studies have shown that acupuncture improves emotional problems such as anxiety, depression, and mental stress in unspecified people with mental problems; therefore, it is expected to be effective in improving emotional problems in women with infertility. Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Depression Mood Review
37893778 One study compared acupuncture plus fluoxetine to fluoxetine alone using depression-related assessment scales and reported that acupuncture plus fluoxetine treatment resulted in a statistically significant improvement in the HAM-D scores compared with fluoxetine treatment alone (p < 0.05). Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Depression Review
37893778 The meta-analysis indicated that acupuncture treatment was more effective in improving the anxiety-related assessment scores of the STAI, SAS, and APAIS and the depression-related assessment SDS scores than the control interventions. Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Depression Review
37893778 Our review and meta-analysis suggest that acupuncture may be an effective and safe treatment for emotional problems, particularly anxiety and depression, in women with infertility. Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. Anxiety Depression Mood Review
37954034 Existing evidence indicates that acupuncture as an adjunctive therapy can improve the total effective rate of SZ patients, reduce the incidence of adverse reactions, improve clinical symptoms, and alleviate depression and anxiety in SZ patients. Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. Adverse Reactions Anxiety Depression Review
37960761 A recent randomized controlled trial (RCT) claimed that acupuncture can significantly improve the clinical symptoms of PMI, and can also be used as a treatment for comorbid PMI and depression. Medicine (Baltimore). 2023 Nov 10;102(45):e35942. doi: 10.1097/MD.0000000000035942. Depression Review
37998449 Preclinical animal studies utilizing acupuncture to treat animal models of PTSD have shown promising results, including improvements in anxiety, fear, sleep disturbances, cognitive symptoms, and depression. Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. Insomnia Anxiety Depression Review
38027491 For example, acupuncture at the Dachangshu (BL 25) acupoint can alleviate depression anxiety-like behavior in a mouse model of visceral pain by regulating the expression of P2Y12 receptors in the PFC and cannabinoid receptors in the hippocampus. Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. Visceral Pain Anxiety Depression Review
38027491 Acupuncture has been shown to relieve visceral pain, depression, anxiety, and other negative emotions by regulating the functional activities of certain brain regions, including the regulation of receptor expression and neurotransmitter release, including serotonin and epinephrine (Figure 1). Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. Visceral Pain Anxiety Depression Mood Review
38050318 The study found that Jianpi Tiaogan Decoction combined with Yiyi navel acupuncture treatment of liver depression and spleen deficiency-type simple obesity can significantly reduce the body mass and other related indicators, improve the level of blood lipid metabolism, and improve the clinical symptoms of liver depression and spleen deficiency, thereby improving the quality of life of patients. Medicine (Baltimore). 2023 Dec 1;102(48):e36071. doi: 10.1097/MD.0000000000036071. Depression Review
38078016 In recent years, acupuncture-related bibliometrics have grown exponentially, including acupuncture for pain, depression, and inflammation. J Pain Res. 2023 Dec 5;16:4165-4180. doi: 10.2147/JPR.S442151. eCollection 2023. Depression Review
38078016 A randomized controlled study found that acupuncture relieved physical and psychological fatigue and reduced the incidence of anxiety and depression. J Pain Res. 2023 Dec 5;16:4165-4180. doi: 10.2147/JPR.S442151. eCollection 2023. Anxiety Depression Review
38125513 Targeting BDNF with acupuncture: A novel integrated strategy for diabetes and depression comorbidity Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 Acupuncture may effectively improve symptoms in patients with diabetes and depression, but the underlying mechanism remains unclear. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 Brain-derived neurotrophic factor (BDNF) may play a vital role in the effects of acupuncture on diabetes and depression comorbidity. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 This review summarizes the potential role of BDNF in acupuncture for diabetes and depression comorbidity. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 BDNF levels are reduced in diabetes and depression, and acupuncture may increase BDNF expression, improving symptoms and glycemic control. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 High-quality research is needed to validate the efficacy of acupuncture for diabetes and depression comorbidity. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 Improved understanding of the links between diabetes, depression and acupuncture may enable targeted and individualized patient care. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 Under the guidance of traditional Chinese medicine, acupuncture may improve BDNF levels and alleviate symptoms of diabetes and depression. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 Clarifying the relationship between acupuncture, BDNF and diabetes-depression comorbidity may optimize treatment strategies. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 This review summarizes the evidence for the role of BDNF in the effects of acupuncture on diabetes and depression comorbidity. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 The effect of BDNF in acupuncture for diabetes and depression Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 Clinical study on acupuncture for diabetes and depression Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 Acupuncture demonstrates therapeutic potential for T2DM and depression. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 After acupuncture, the fasting blood glucose levels, HbA1c, and Hamilton Depression Scale (HAMD) decreased. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 This study showed that acupuncture can improve the depression and anxiety symptoms of T2DM and the glucose metabolism disorder, which helps control blood sugar. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Anxiety Depression Review
38125513 This study showed that acupuncture can effectively improve the clinical symptoms of T2DM patients with depression. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 The effect of BDNF in acupuncture for depression Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 's study showed that BDNF in the hippocampus was inversely associated with depression-like behavior and that the antidepressant effect of acupuncture might be related to improved hippocampal BDNF protein expression. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 In addition, many studies have explored the mechanism of acupuncture for treating depression. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 In depression model rats, miRNA-16 in hippocampus and raphe nucleus can target and regulate BDNF expression, and p11/tPA/BDNF signal pathway may participate in the antidepressant effect of acupuncture. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 investigated whether stimulation of an acupoint using a mechanical acupuncture instrument could reduce depression like behavior caused by estrogen deficiency in ovariectomized rats. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 After mechanical acupuncture instrument stimulation of Sanyinjiao (SP6), rats showed reduced depression-like behavior and increased hippocampal BDNF and neuropeptide Y (NPY) release. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 The effect of BDNF in acupuncture for diabetes and depression comorbidity Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 While the existing literature has provided preliminary insights into the potential role of BDNF in acupuncture therapy for the diabetes and depression comorbidity, numerous mysteries remain unsolved. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 First and foremost, additional clinical trials, particularly randomized controlled trials, are essential to assess the efficacy of acupuncture therapy for diabetes and depression comorbidity. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 By discussing these future research directions, we aim to provide readers with a clear path to advance further research in this field and better comprehend the role of BDNF in acupuncture therapy for diabetes and depression comorbidity. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 However, research on acupuncture for diabetes and depression remains limited, with studies frequently characterized by small sample sizes, a lack of multicenter randomized controlled trials, and reliance on subjective outcome measurements. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 The mechanisms by which acupuncture impacts the diabetes and depression comorbidity are yet to be confirmed. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38125513 In conclusion, acupuncture provides unique advantages for the holistic, patient-centered management of diabetes and depression comorbidity. Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. Depression Review
38189090 A few separate studies have reported the role of acupuncture treatment in common symptoms in patients with CKD, including intradialytic hypotension on dialysis, poor sleep quality, anxiety, depression, muscle cramps, and dialysis imbalance syndrome (supplemental Figure S6). Ren Fail. 2024 Dec;46(1):2301504. doi: 10.1080/0886022X.2023.2301504. Epub 2024 Jan 8. Anxiety Depression Sleep Quality Review
38200908 However, electro-acupuncture was more effective in improving defecation frequency, difficulty in defecation, and constipation, as well as relieving depression, anxiety, and other psychological symptoms. Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. Anxiety Depression Review
1288930 There were less respiratory depression, hypotension, cardiac arrhythmia and less amount of liquid infusion needed than that of the epidural block during operation. Zhen Ci Yan Jiu. 1992;17(2):87-9. Depression Clinic
22295830 The change of ETsev value was recorded, the heart rate (HR) and blood pressure (BP) were observed, and the time from the end of operation to extubation, awake time were recorded adverse events such as restlessness, shivering, postoperative pain, nausea and vomiting, cases of respiratory depression, the analepsia quality, the time of first anus exhaust, the awaking of patient in operation and satisfactory of patients after surgery were recorded so as to evaluate the effect of acupuncture anesthesia. Zhongguo Zhen Jiu. 2012 Jan;32(1):59-64. Heart Rate Nausea and Vomiting Blood Pressure Depression Clinic
33415861 The two groups were compared in terms of the sedative and analgesic effects of anesthesia, amount of anesthetics used, incidence rate of intraoperative snore and respiratory depression, and change in serum beta-endorphin level before anesthesia, before surgery, and after the surgery. Zhen Ci Yan Jiu. 2020 Dec 25;45(12):1006-9. doi: 10.13702/j.1000-0607.200116. Analgesic Effect Depression Acupuncture Anesthesia Effect Clinic
33415861 Compared with the control group, the sedation score, the amounts of fentanyl and propofol used, the incidence rates of intraoperative snore and respiratory depression in the treatment group were obviously lower (P<0.05, P<0.01). Zhen Ci Yan Jiu. 2020 Dec 25;45(12):1006-9. doi: 10.13702/j.1000-0607.200116. Depression Sedation Clinic
33415861 CONCLUSION: In microwave ablation of benign thyroid nodules, combined acupuncture-medicine anesthesia has good sedative and analgesic effects and can reduce the amounts of anesthetics used as well as the incidence rates of intraoperative snore and respiratory depression. Zhen Ci Yan Jiu. 2020 Dec 25;45(12):1006-9. doi: 10.13702/j.1000-0607.200116. Analgesic Effect Depression Clinic
2052392 All patients completed a questionnaire in order to characterize state tension and stress, degrees of neuroticism, extroversion, depression and psychosomatic disorders. Pain. 1991 Mar;44(3):241-247. doi: 10.1016/0304-3959(91)90092-C. Depression Clinic
11932132 Alcohol use was assessed, along with depression, anxiety, functional status, and preference for therapy. J Subst Abuse Treat. 2002 Mar;22(2):71-7. doi: 10.1016/s0740-5472(01)00217-3. Anxiety Depression Clinic
36034956 The pain level (visual analogue scale (VAS)), physical and mental stress (heart rate (HR), mean arterial pressure (MAP), depression scale (PHQ-9), and anxiety scale (GAD-7)), complications, rehabilitation quality, and analgesia satisfaction were observed. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Heart Rate Anxiety Depression Clinic
36034956 Physical and mental stress: heart rate (HR) and mean arterial pressure (MAP) were recorded at admission, 6 hours before surgery, and 6 hours and 24 hours after surgery, respectively, and psychological stress state was assessed by patient health questionnaire depression scale (PHQ-9) and generalized anxiety scale (GAD-7). Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Heart Rate Anxiety Depression Clinic
36034956 These indicated that multimodal analgesia combined with auricular application therapy could decrease the degree of physical and mental stress through reducing the preoperative pain, showing that the blood pressure, HR, and anxiety depression were decreased. Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. Heart Rate Anxiety Blood Pressure Depression Clinic
23573118 High-dose opioids are used for pain management, but they may cause side effects such as respiratory depression. Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. Side Effects Depression Clinic
23573118 It is controversially discussed whether opioids after median sternotomy lead to side effects such as respiratory depression, vomiting, nausea, and sedation. Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. Side Effects Nausea and Vomiting Depression Sedation Clinic
27688791 LR3: it is on the dorsum of the foot, in the depression anterior to the junction of the first and second metatarsal bones (Chinese National Standards GB/T12346) (Figure 2). Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. Depression Clinic
31915045 The HPA axis has many functions including regulation of appetite, sleep, sexual desires and adaptation to stress; dysfunction of the HPA axis is thought to be primarily responsible for psychological/behavioral symptoms (pain sensitivity, depression, fatigue). Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. Depression Clinic
32062864 nausea, vomiting, ileus, pruritus, and respiratory depression) with the goal of improving and expediting patients' recovery after surgery.1 Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. Nausea and Vomiting Depression Clinic
33154688 The following participants were excluded: (1) patients with central nervous system and mental diseases; (2) patients with preoperative sleep disturbances; (3) patients with a history of sedative, analgesic, or antidepression drug use; (4) patients with sleep apnea or moderate and severe obstructive sleep apnea-hypopnea syndrome; (5) patients with sinus bradycardia or atrioventricular block grade II or greater; and (6) patients with severe visual or hearing impairment or who were unable to communicate. Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. Insomnia Depression Clinic
33488793 Simultaneously, TEAS was able to reverse decreased serum levels of IL-2 and IFN-xcexb3, reduce the level of IL-4 and restore the balance of Th1/Th2, thereby partially attenuating perioperative immune function depression in patients with breast cancer. Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. Immunity Depression Clinic
34682857 In addition, the Chinese version of Spielbergerxe2x80x99s State-Trait Anxiety Inventory (STAI) and the Chinese version of Beckxe2x80x99s Depression Inventory II (BDI II) were used to assess the level of anxiety and depression, respectively. J Clin Med. 2021 Oct 15;10(20):4731. doi: 10.3390/jcm10204731. Anxiety Depression Clinic
36098938 Opioids are commonly used analgesics in the postoperative period, which can cause common complications such as constipation, respiratory depression, nausea-vomiting, and pruritus. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Nausea and Vomiting Depression Clinic
36098938 The occurrence of postoperative adverse events was evaluated on the basis of the incidence of PONV, pruritis, and respiratory depression. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Depression Clinic
36098938 There was no significant difference in pruritis or respiratory depression in all three groups. Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. Depression Clinic
36749304 The reduction in Zung Selfxe2x80x90Rating Depression Scale (SDS) score was calculated as the secondary outcome. Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Depression Clinic
36749304 SDS was used to evaluate the subjectively reported depression by the patients. Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Depression Clinic
36749304 The scale consisted of 20 items and each item was divided into 4 levels according the frequency of symptoms, which is suitable for adults with depression. Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Depression Clinic
36749304 ALFF, amplitude of lowxe2x80x90frequency fluctuation; PCUN, precuneus; NRS, numerical rating scale; SDS, Selfxe2x80x90Rating Depression Scale. Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Depression Clinic
36749304 This preliminary clinical trial has shown that EA reduced pain intensity and depression tendency after TKA. Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Depression Clinic
36749304 The surgical injury triggers a myriad of responses in the pain matrix, from sensitization of central pain pathways to anxiety and depression (Small & Laycock,). Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Anxiety Depression Clinic
36749304 The SDS score in EA group showed the patients receiving EA had a lower tendency to develop depression, which can be explained by the reduced pain severity and negative emotions after EA, and the resultant increase of the functional activities in the relevant brain regions. Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. Depression Mood Clinic
30381011 Additionally, a current study by Wu et al suggested that TAES was able to partially attenuate the postoperative immune depression of patients with lung cancer by regulating the balance of T lymphocytes and the expression levels of related cytokines and transcription factors, but they did not discuss the impact of TEAS on NK cells and related immunologic factors, such as TNF-xcexb1 and IL-6. Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. Immunity Depression Clinic
29773696 The validated Korean version of the ODI was administered before treatment at assessments 2, 5, 9,10 and 11xc2xa0(weeks 1, 2, 4, 8 and 12).xc2xa0The validated Korean version of the EQ-5D includes generic questions about personal health-related quality of life and consists of five dimensions pertaining to mobility, self-care, usual daily activities, pain and discomfort, and anxiety/depression. BMJ Open. 2018 May 17;8(5):e018464. doi: 10.1136/bmjopen-2017-018464. Anxiety Depression Clinic
28254098 A previous study on rats showed that simultaneous acupuncture stimulation at the ""Bai-Hui"" (GV 20) and the ""Yintang"" (Ex-HN3) acupoints alleviated the state of depression to an extent similar to that achieved by pharmacotherapy. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Depression Mechanism
28254098 For the purposes of testing the effect of acupuncture on depressive symptoms, we treated a depression model rat, where depression had been induced by using a mild water-immersion stress technique, with either acupuncture stimulation at only one acupuncture point (GV 20 or Ex-HN3) or an antidepressant, and we measured the immobile time for evaluating the state of depression. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Depression Mechanism
28254098 Anxiety, as a symptom commonly associated with depression, was also evaluated by measuring the number of head dips. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Anxiety Depression Mechanism
28254098 From this study, single acupuncture stimulation at either ""GV 20"" or ""Ex-HN3"" alleviated neither the state of depression nor the anxiety. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Anxiety Depression Mechanism
28254098 The water-immersion stress used to make the depression model rats was shown not to induce anxiety; however, the stress induced by immobilizing the rats for acupuncture stimulation did lead to anxiety. J Acupunct Meridian Stud. 2017 Jan;10(1):26-32. doi: 10.1016/j.jams.2016.11.006. Epub 2016 Dec 9. Anxiety Depression Mechanism
27264487 In the present study, we investigated the changes of microRNA (miRNA) expression upon depression and electro-acupuncture (EA) intervention in chronic unpredictable mild stress (CUMS) rats using microarray analysis. Neurosci Lett. 2016 Aug 3;627:160-7. doi: 10.1016/j.neulet.2016.05.054. Epub 2016 Jun 2. Depression Mechanism
27264487 Among these pathways and GO, about 20 pathways and 21 GO were related to depression. Neurosci Lett. 2016 Aug 3;627:160-7. doi: 10.1016/j.neulet.2016.05.054. Epub 2016 Jun 2. Depression Mechanism
27264487 Changes of miR-383-5p and miR-764-5p indicated that EA might exert its therapeutic effect on depression through promoting the neurotrophy and inhibiting the abnormal apoptosis of neurons as well as other correlative signal pathways. Neurosci Lett. 2016 Aug 3;627:160-7. doi: 10.1016/j.neulet.2016.05.054. Epub 2016 Jun 2. Depression Mechanism
27264487 In conclusion, our present study enriched the understanding of pathological process of depression and revealed possible mechanisms of EA on depression. Neurosci Lett. 2016 Aug 3;627:160-7. doi: 10.1016/j.neulet.2016.05.054. Epub 2016 Jun 2. Depression Mechanism
36914042 Acupuncture inhibits autophagy and repairs synapses by activating the mTOR pathway in Parkinson's disease depression model rats. Brain Res. 2023 Jun 1;1808:148320. doi: 10.1016/j.brainres.2023.148320. Epub 2023 Mar 11. Depression Mechanism
36914042 Acupuncture is a good treatment for depression in Parkinson's disease (DPD), so the possible mechanism of acupuncture in the treatment of DPD was explored in this study. Brain Res. 2023 Jun 1;1808:148320. doi: 10.1016/j.brainres.2023.148320. Epub 2023 Mar 11. Depression Mechanism
35970043 Electroacupuncture remodels the extracellular matrix and promotes synaptic plasticity in a mouse model of depression. Biochem Biophys Res Commun. 2022 Oct 20;626:44-50. doi: 10.1016/j.bbrc.2022.07.077. Epub 2022 Aug 4. Depression Mechanism
35970043 Depression is a chronic and recurrent disease without satisfactory treatment strategies. Biochem Biophys Res Commun. 2022 Oct 20;626:44-50. doi: 10.1016/j.bbrc.2022.07.077. Epub 2022 Aug 4. Depression Mechanism
35970043 In this study, the lipopolysaccharide (LPS)-induced depression mice model was used to evaluate the anti-depressant effects of EA treatment. Biochem Biophys Res Commun. 2022 Oct 20;626:44-50. doi: 10.1016/j.bbrc.2022.07.077. Epub 2022 Aug 4. Depression Mechanism
29524471 Electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression. Brain Res Bull. 2018 May;139:256-262. doi: 10.1016/j.brainresbull.2018.03.004. Epub 2018 Mar 7. Depression Mechanism
26773866 Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression. Neurosci Lett. 2016 Feb 26;615:66-71. doi: 10.1016/j.neulet.2016.01.004. Epub 2016 Jan 8. Depression Mechanism
26773866 Hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathogenesis of depression. Neurosci Lett. 2016 Feb 26;615:66-71. doi: 10.1016/j.neulet.2016.01.004. Epub 2016 Jan 8. Depression Mechanism
26773866 Dysfunction of the hippocampal serotonin (5-hydroxytryptamine, 5-HT) system has been shown to be a key factor in depression. Neurosci Lett. 2016 Feb 26;615:66-71. doi: 10.1016/j.neulet.2016.01.004. Epub 2016 Jan 8. Depression Mechanism
26773866 In our study, we investigated the antidepressant-like effect and mechanism of EA for depression rat models. Neurosci Lett. 2016 Feb 26;615:66-71. doi: 10.1016/j.neulet.2016.01.004. Epub 2016 Jan 8. Depression Mechanism
26773866 Depression in rats was induced by chronic unpredictable mild stress (CUMS). Neurosci Lett. 2016 Feb 26;615:66-71. doi: 10.1016/j.neulet.2016.01.004. Epub 2016 Jan 8. Depression Mechanism
26773866 These results indicated that EA treatment could act on depression by modulating HPA axis and enhancing hippocampal 5-HT/5-HT1AR in CUMS Rats. Neurosci Lett. 2016 Feb 26;615:66-71. doi: 10.1016/j.neulet.2016.01.004. Epub 2016 Jan 8. Depression Mechanism
21643998 The maternal separation (MS) animal model has been widely used to study early life stress and several psychiatric conditions such as depression and anxiety. Cell Mol Neurobiol. 2011 Nov;31(8):1123-7. doi: 10.1007/s10571-011-9718-x. Epub 2011 Jun 5. Anxiety Depression Mechanism
22714092 The present study investigated the possible role of acupuncture in alleviating depression-like behavioral changes and examined changes in the levels of serotonin (5-HT), dopamine (DA), and their metabolites in the hippocampus (HP) and prefrontal cortex (PFC) of maternally separated rat pups. Neurochem Res. 2012 Oct;37(10):2092-8. doi: 10.1007/s11064-012-0830-1. Epub 2012 Jun 20. Depression Mechanism
22714092 These results suppose that the functional recovery of prefrontal-limbic system by acupuncture stimulation plays an important role in acupuncture-induced benefits in this animal model of depression. Neurochem Res. 2012 Oct;37(10):2092-8. doi: 10.1007/s11064-012-0830-1. Epub 2012 Jun 20. Depression Mechanism
12230028 A total of 18 animals (two heifers and 16 cows) that had failed to conceive to 3-9 services were treated by aquapuncture, in which 10 ml and 5 ml of 50% glucose solution were injected at Baihui (Hundred Meetings, the depression in the center of the lumbosacral space) and Shenpeng (Kidney Shelf, the depression in the space between the lumbar vertebral transverse processes 5-6) acupoints, respectively with a 21G, 1.5-inch hypodermic needle. Am J Chin Med. 2002;30(2-3):397-404. doi: 10.1142/S0192415X02000296. Depression Kidney Mechanism
22796291 Modulatory effects of acupuncture on murine depression-like behavior following chronic systemic inflammation. Brain Res. 2012 Sep 7;1472:149-60. doi: 10.1016/j.brainres.2012.07.009. Epub 2012 Jul 13. Depression Mechanism
22796291 Depression associated with inflammatory immune responses may be an important medical problem from the perspective of quality of life in old age because chronic inflammation is recognized to have a close connection with the aging process. Brain Res. 2012 Sep 7;1472:149-60. doi: 10.1016/j.brainres.2012.07.009. Epub 2012 Jul 13. Immunity Depression Mechanism
22796291 Activated proinflammatory cytokines induce depression-like behavior by stimulating the expression of indoleamine-2,3-dioxygenase, an enzyme catalyzing the conversion of tryptophan to kynurenine, and by reducing brain synaptic activities of serotonin and dopamine. Brain Res. 2012 Sep 7;1472:149-60. doi: 10.1016/j.brainres.2012.07.009. Epub 2012 Jul 13. Depression Mechanism
22796291 Experimental inoculation of Bacillus Calmette-Guerin vaccine (BCG) in the mouse gradually and continuously elicits chronic inflammation-associated depression-like behavior. Brain Res. 2012 Sep 7;1472:149-60. doi: 10.1016/j.brainres.2012.07.009. Epub 2012 Jul 13. Depression Mechanism
22796291 Despite extensive use of acupuncture therapy for treating various psychosomatic disorders in the Oriental medicine, an experimental study showing antidepressant-like activity of acupuncture stimulation has not been performed in the inflammation-associated depression-like animal behavior yet. Brain Res. 2012 Sep 7;1472:149-60. doi: 10.1016/j.brainres.2012.07.009. Epub 2012 Jul 13. Depression Mechanism
22796291 We confirmed that acupuncture stimulation significantly reduced depression-like behavior and that it lowered the kynurenine/tryptophan ratio and raised the serum kynurenic acid/3-hydroxykynurenine ratio. Brain Res. 2012 Sep 7;1472:149-60. doi: 10.1016/j.brainres.2012.07.009. Epub 2012 Jul 13. Depression Mechanism
22796291 Taken together, these findings may indicate that acupuncture has antidepressant-like effects on murine chronic inflammation-associated depression-like behavior due to its modulatory effects on tryptophan-kynurenine metabolism and dopamine metabolism in the brain. Brain Res. 2012 Sep 7;1472:149-60. doi: 10.1016/j.brainres.2012.07.009. Epub 2012 Jul 13. Depression Mechanism
35820551 The NLRP3-mediated pyroptosis, which could affect inflammation response, plays a key role in the development of depression. Neurosci Lett. 2022 Aug 10;785:136787. doi: 10.1016/j.neulet.2022.136787. Epub 2022 Jul 9. Depression Mechanism
35820551 Acupuncture has been shown to be an effective treatment for depression. Neurosci Lett. 2022 Aug 10;785:136787. doi: 10.1016/j.neulet.2022.136787. Epub 2022 Jul 9. Depression Mechanism
35820551 Here, depression model of rats was induced by chronic unpredictable mild stress (CUMS) for 4 weeks. Neurosci Lett. 2022 Aug 10;785:136787. doi: 10.1016/j.neulet.2022.136787. Epub 2022 Jul 9. Depression Mechanism
35820551 Rats' depression-like phenotypes were reflected with behavioral tests and biological detection methods. Neurosci Lett. 2022 Aug 10;785:136787. doi: 10.1016/j.neulet.2022.136787. Epub 2022 Jul 9. Depression Mechanism
35820551 Results showed that acupuncture significantly improved the depression-like behavior of CUMS rat, suppressed the expressions of NLRP3, ASC, caspase-1, GSDMD, IL-1beta, IL-18, HMGB1, IFN-gamma, IL-6 and TNF-alpha in the serum and hippocampus, restored the %area of microglia, astrocytes and neuronal cells in the hippocampus. Neurosci Lett. 2022 Aug 10;785:136787. doi: 10.1016/j.neulet.2022.136787. Epub 2022 Jul 9. Depression Mechanism
35820551 These indicate that acupuncture can prevent CUMS-induced depression-like behaviors by reducing NLRP3-mediated pyroptosis and inflammation. Neurosci Lett. 2022 Aug 10;785:136787. doi: 10.1016/j.neulet.2022.136787. Epub 2022 Jul 9. Depression Mechanism
19429024 Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats. Neurosci Lett. 2009 Apr 10;453(3):151-6. doi: 10.1016/j.neulet.2009.01.076. Epub 2009 Feb 4. Depression Mechanism
19429024 Repeated injection of corticosterone (CORT) induces dysregulation in the HPA axis, resulting in depression and anxiety. Neurosci Lett. 2009 Apr 10;453(3):151-6. doi: 10.1016/j.neulet.2009.01.076. Epub 2009 Feb 4. Anxiety Depression Mechanism
19429024 Acupuncture significantly reduced depression- and anxiety-like behavior and increased NPY expression in the hypothalamus. Neurosci Lett. 2009 Apr 10;453(3):151-6. doi: 10.1016/j.neulet.2009.01.076. Epub 2009 Feb 4. Anxiety Depression Mechanism
19429024 These results demonstrated that stimulation of the PC6 acupoint suppresses the symptopathology of the hypoactivated HPA axis in chronic CORT-induced rat model of depression. Neurosci Lett. 2009 Apr 10;453(3):151-6. doi: 10.1016/j.neulet.2009.01.076. Epub 2009 Feb 4. Depression Mechanism
30204276 The PCOS rats presented with reproductive dysfunctions such as lack of regular oestrous cyclicity, metabolic disorders such as increased body weight and insulin resistance, and depression and anxiety-like behaviours. Exp Physiol. 2018 Dec;103(12):1618-1632. doi: 10.1113/EP087163. Epub 2018 Oct 23. Anxiety Depression Mechanism
29601832 Given the importance of depression and the adverse effects of conventional treatment, it is necessary to seek complementary therapies. Neurosci Lett. 2018 May 14;675:48-53. doi: 10.1016/j.neulet.2018.03.057. Epub 2018 Mar 27. Adverse Reactions Depression Mechanism
29601832 In a rat model of depression, this study aimed to assess the behavioral and morphological effects of embedding absorbable thread in acupoints (acu-catgut), and compare the results to those of fluoxetine treatment and the corresponding control groups. Neurosci Lett. 2018 May 14;675:48-53. doi: 10.1016/j.neulet.2018.03.057. Epub 2018 Mar 27. Depression Mechanism
36706710 BACKGROUND: Acupuncture has shown the preventive effects on depression in rats with chronic unpredictable mild stress (CUMS). Biochem Biophys Res Commun. 2023 Feb 26;646:86-95. doi: 10.1016/j.bbrc.2023.01.046. Epub 2023 Jan 16. Depression Mechanism
36706710 However, the mechanisms of acupuncture for preventing depression still need to be explored. Biochem Biophys Res Commun. 2023 Feb 26;646:86-95. doi: 10.1016/j.bbrc.2023.01.046. Epub 2023 Jan 16. Depression Mechanism
36706710 In the study, acupuncture was applied to a rat depression model of CUMS, high-mobility group box 1(HMGB1)/toll-like receptor 4 (TLR4) and brain-spleen axis were assessed. Biochem Biophys Res Commun. 2023 Feb 26;646:86-95. doi: 10.1016/j.bbrc.2023.01.046. Epub 2023 Jan 16. Depression Mechanism
36706710 Behavioral tests and biological detection methods were conducted in sequence to evaluate depression-like phenotypes in rats. Biochem Biophys Res Commun. 2023 Feb 26;646:86-95. doi: 10.1016/j.bbrc.2023.01.046. Epub 2023 Jan 16. Depression Mechanism
36706710 RESULTS: The results showed CUMS induced depression-like behaviors, hyper-activation of HMGB1/TLR4 signaling pathway, elevated inflammation in amygdala and peripheral blood, and hyperactivation of hypothalamic-pituitary-adrenal (HPA) axis. Biochem Biophys Res Commun. 2023 Feb 26;646:86-95. doi: 10.1016/j.bbrc.2023.01.046. Epub 2023 Jan 16. Depression Mechanism
36706710 CONCLUSION: Acupuncture prevented and ameliorated depression-like symptoms induced by CUMS, possibly via regulating inflammation through brain-spleen axis mediated by HMGB1/TLR4 signaling pathway and HPA axis regulation. Biochem Biophys Res Commun. 2023 Feb 26;646:86-95. doi: 10.1016/j.bbrc.2023.01.046. Epub 2023 Jan 16. Depression Mechanism
27915092 Acupuncture ameliorates inflammatory response in a chronic unpredictable stress rat model of depression. Brain Res Bull. 2017 Jan;128:106-112. doi: 10.1016/j.brainresbull.2016.11.010. Epub 2016 Nov 30. Depression Mechanism
27915092 Depression is one of the most common psychiatric disorders. Brain Res Bull. 2017 Jan;128:106-112. doi: 10.1016/j.brainresbull.2016.11.010. Epub 2016 Nov 30. Depression Mechanism
27915092 Chronic inflammatory response has been viewed as a key factor in depression. Brain Res Bull. 2017 Jan;128:106-112. doi: 10.1016/j.brainresbull.2016.11.010. Epub 2016 Nov 30. Depression Mechanism
27915092 Acupuncture in Chinese medicine has been shown to be an effective treatment for depression. Brain Res Bull. 2017 Jan;128:106-112. doi: 10.1016/j.brainresbull.2016.11.010. Epub 2016 Nov 30. Depression Mechanism
34636496 Acupuncture inhibits NLRP3 inflammasome activation in the prefrontal cortex of a chronic stress rat model of depression. Anat Rec (Hoboken). 2021 Nov;304(11):2470-2479. doi: 10.1002/ar.24778. Epub 2021 Oct 12. Depression Mechanism
34636496 The Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-driven inflammatory response plays a key role in the pathophysiology of depression. Anat Rec (Hoboken). 2021 Nov;304(11):2470-2479. doi: 10.1002/ar.24778. Epub 2021 Oct 12. Depression Mechanism
34636496 Mounting evidence suggests that acupuncture is an effective treatment for depression. Anat Rec (Hoboken). 2021 Nov;304(11):2470-2479. doi: 10.1002/ar.24778. Epub 2021 Oct 12. Depression Mechanism
34636496 In this study, we investigated the effects of acupuncture treatment at the acupoints Baihui (GV20) and Yintang (GV29) on NLRP3 inflammasome in the prefrontal cortex (PFC) of an animal model of depression. Anat Rec (Hoboken). 2021 Nov;304(11):2470-2479. doi: 10.1002/ar.24778. Epub 2021 Oct 12. Depression Mechanism
33607237 Lipidomics reveals that acupuncture modulates the lipid metabolism and inflammatory interaction in a mouse model of depression. Brain Behav Immun. 2021 May;94:424-436. doi: 10.1016/j.bbi.2021.02.003. Epub 2021 Feb 16. Depression Mechanism
33607237 Depression is a serious disease that has considerable impact on lipid metabolism and inflammatory responses. Brain Behav Immun. 2021 May;94:424-436. doi: 10.1016/j.bbi.2021.02.003. Epub 2021 Feb 16. Depression Mechanism
33607237 Recent studies have shown that leptin, which is well known as a mediator of energy homeostasis and is a cytokine in inflammatory response, plays an important role in depression. Brain Behav Immun. 2021 May;94:424-436. doi: 10.1016/j.bbi.2021.02.003. Epub 2021 Feb 16. Depression Mechanism
33607237 Acupuncture is widely used to treat depression; however, the underlying mechanisms and the effect of acupuncture on depression remain poorly understood. Brain Behav Immun. 2021 May;94:424-436. doi: 10.1016/j.bbi.2021.02.003. Epub 2021 Feb 16. Depression Mechanism
33607237 In this study, we utilized the chronic restraint stress (CRS) induced depression model and acupuncture treatment was performed at KI10, LR8, LU8, LR4 (AP) or non-acupoint (NP). Brain Behav Immun. 2021 May;94:424-436. doi: 10.1016/j.bbi.2021.02.003. Epub 2021 Feb 16. Depression Mechanism
33607237 Acupuncture treatment at AP improved depression-like behavior in an open-field test, forced swimming test, and marble burying test. Brain Behav Immun. 2021 May;94:424-436. doi: 10.1016/j.bbi.2021.02.003. Epub 2021 Feb 16. Depression Mechanism
33607237 In conclusion, these results show that AP acupuncture treatment effectively alleviated the depression-like behavior, affected immune responses, and altered hepatic lipid metabolism through the attenuation of leptin insensitivity. Brain Behav Immun. 2021 May;94:424-436. doi: 10.1016/j.bbi.2021.02.003. Epub 2021 Feb 16. Immunity Depression Mechanism
7248823 Reversal by acupuncture of cardiovascular depression induced with morphine during halothane anaesthesia in dogs. Can Anaesth Soc J. 1981 Mar;28(2):129-35. doi: 10.1007/BF03007256. Cardiovascular Depression Mechanism
29231507 [Effect of acupuncture treatment on gene expression of neurotransmitters of brain tissue in rats with post-stroke depression]. Zhongguo Zhen Jiu. 2017 Jun 12;37(6):637-641. doi: 10.13703/j.0255-2930.2017.06.017. Depression Mechanism
29231507 OBJECTIVE: To observe the effects of acupuncture on mRNA of the neurotransmitter serotonin transporter (5-HTT), 5-HT(1A)receptor (5-HT(1A)R), norepinephrinealpha2 receptor (NEalpha(2)R) in brain tissue in rats with post-stroke depression. Zhongguo Zhen Jiu. 2017 Jun 12;37(6):637-641. doi: 10.13703/j.0255-2930.2017.06.017. Depression Mechanism
29231507 The model of post-stroke depression was established by occlusion of middle cerebral artery and chronic unpredictable mild stress method. Zhongguo Zhen Jiu. 2017 Jun 12;37(6):637-641. doi: 10.13703/j.0255-2930.2017.06.017. Depression Mechanism
29231507 CONCLUSIONS: Acupuncture could significantly improve behavioral change in rats with post-stroke depression, which may be related to the regulation of 5-HT, NE in cerebral cortex as well as mRNA expressions of 5-HTT, 5-HT(1A)R, NEalpha(2)R in hippocampus, raphe nucleus and locus coeruleus. Zhongguo Zhen Jiu. 2017 Jun 12;37(6):637-641. doi: 10.13703/j.0255-2930.2017.06.017. Depression Mechanism
35579004 BACKGROUND: GV20 and Yintang are important targets in acupuncture treatment for depression. Acupunct Med. 2023 Feb;41(1):38-47. doi: 10.1177/09645284221085279. Epub 2022 May 17. Depression Mechanism
35579004 METHODS: We compared the antidepressant effects of manual acupuncture (MA) stimulation at GV20 and Yintang, compared to acupuncture stimulation at two control point locations on the back of the mice (overlying the spinal column) and imipramine administration in a forced swimming (FS)-induced mouse model of depression, and examined the mRNA and protein expression of neurotrophic factors, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, and NT-4/5 in the brains by real-time polymerase chain reaction in two different experimental schedules - preventive (MA given alongside FS modelling) and therapeutic (MA given after FS-induced depression was already established). Acupunct Med. 2023 Feb;41(1):38-47. doi: 10.1177/09645284221085279. Epub 2022 May 17. Depression Mechanism
35579004 RESULTS: MA at GV20 and Yintang significantly reduced the immobility time of mice with FS-induced depression in both preventive and therapeutic experimental designs, with effects that were comparable to those of imipramine administration. Acupunct Med. 2023 Feb;41(1):38-47. doi: 10.1177/09645284221085279. Epub 2022 May 17. Depression Mechanism
35579004 CONCLUSION: Our findings suggest that simultaneous acupuncture stimulation at GV20 and Yintang is effective for the prevention and treatment of depression, and the effect likely involves modulation of the expression of multiple neurotrophic factors. Acupunct Med. 2023 Feb;41(1):38-47. doi: 10.1177/09645284221085279. Epub 2022 May 17. Depression Mechanism
37519181 Chronic pain may restrict activities of daily living, including work, learning, social life, and can lead to anxiety, depression, and sleep disturbance. J Integr Neurosci. 2023 Jul 17;22(4):97. doi: 10.31083/j.jin2204097. Insomnia Anxiety Depression Mechanism
38142722 Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis. Brain Res. 2023 Dec 22;1826:148715. doi: 10.1016/j.brainres.2023.148715. Depression Mechanism
38142722 BACKGROUND: The treatment of depression with acupuncture has been documented. Brain Res. 2023 Dec 22;1826:148715. doi: 10.1016/j.brainres.2023.148715. Depression Mechanism
38142722 METHODS: The current study examined the effects of acupuncture on depression-like behaviors in a rat model of chronic unpredictable mild stress (CUMS), while also exploring its potential mechanisms. Brain Res. 2023 Dec 22;1826:148715. doi: 10.1016/j.brainres.2023.148715. Depression Mechanism
38142722 RESULTS: Acupuncture and fluoxetine could alleviate CUMS-induced depression-like behaviors. Brain Res. 2023 Dec 22;1826:148715. doi: 10.1016/j.brainres.2023.148715. Depression Mechanism
38142722 CONCLUSION: The study's findings indicate that acupuncture has the potential to mitigate depression-like behaviors in rats induced with CUMS by mitigating OS and reducing neuroinflammation. Brain Res. 2023 Dec 22;1826:148715. doi: 10.1016/j.brainres.2023.148715. Depression Mechanism
28986807 CONCLUSION: Acupuncture stimulation at HT 7 can alleviate the behavioral impairment and changes of the cytokines by MS, indicating that acupuncture can help to relieve MS-induced depression. Chin J Integr Med. 2017 Dec;23(12):943-947. doi: 10.1007/s11655-017-2827-8. Epub 2017 Oct 6. Depression Mechanism
26419631 D-IBS patients typically have higher depression score than healthy control. BMC Complement Altern Med. 2015 Sep 29;15:340. doi: 10.1186/s12906-015-0863-5. Depression Mechanism
37548586 LR3 is located in the depression between the first and second metatarsal bones of the dorsal aspect of the hindlimb, one point on each side. Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. Depression Mechanism
37548586 Further, alterations in brain structure can bring about mania, mental depression, sleep disorders, learning and memory impairment, and personality deficits. Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. Learning and Memory Ability Depression Mechanism
32761882 Another study demonstrated that acupuncture with manipulation was superior to drug treatment in regulating blood vessels and improving depression and anxiety in stroke patients (Yu et al., 2014). Brain Behav. 2020 Oct;10(10):e01781. doi: 10.1002/brb3.1781. Epub 2020 Aug 6. Anxiety Depression Mechanism
32796318 The GB30 is located at the junction of the lateral 1/3 and medial 2/3 of the greater trochanter with the sacral hiatus, and GB34 is located in the depression anterior and distal to the head of the fibula (Fig. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Depression Mechanism
32796318 Depression-like behavioral tests Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Depression Mechanism
32796318 The tail suspension test (TST) was used to measure depression-like behavior. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Depression Mechanism
32796318 This study evaluated the antidepressant effects of acupuncture (AP or CP) and amitriptyline (PC) on depression-like behaviors generated in a PSNL neuropathic pain model using the TST. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Neuropathic Pain Depression Mechanism
32796318 In addition, Spearman rank correlation coefficient analyses were performed to investigate whether the changes in DNA methylation were correlated with changes in nociception, anxiety, depression, and cognitive function. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Cognitive Function Anxiety Depression Mechanism
32796318 Global DNA methylation in the PFC was negatively correlated with nociceptive and depression-like behaviors (r = −0.7470, P = 0.0052 for von Frey test; r = −0.6713, P = 0.0168 for acetone test; r = −0.6993, P = 0.0114 for TST), and positively correlated with anxiety-like behavior and cognitive dysfunction (r = 0.6702, P = 0.0171 for OFT; r = 0.8693, P = 0.0002 for EPM; r = 0.6294, P = 0.0283 for Y-maze; r = 0.7719, P = 0.0033 for NOR; Figs. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Cognitive Function Anxiety Depression Mechanism
32796318 Global DNA methylation in the PAG was negatively correlated with nociceptive and depression-like behaviors (r = −0.7399, P = 0.0059 for von Frey test; r = −0.6783, P = 0.0153 for acetone test; r = −0.6434, P = 0.0240 for TST), and positively correlated with anxiety-like behaviors (r = 0.6281, P = 0.0287 for OFT; r = 0.5442, P = 0.0674 for EPM). Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Depression Mechanism
32796318 DNA methylation in the hypothalamus was negatively correlated with anxiety-like behaviors (r = −0.5860, P = 0.0453 for OFT; r = −0.5301, P = 0.0763 for EPM), and positively correlated with depression-like behaviors (r = 0.6364, P = 0.0261 for TST). Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Depression Mechanism
32796318 Global DNA methylation in the HIP was positively correlated with nociceptive and depression-like behaviors (r = 0.6655, P = 0.0182 for von Frey test; r = 0.5105, P = 0.0899 for acetone test; r = 0.8042, P = 0.0016 for TST), and negatively correlated with anxiety-like behavior and cognitive dysfunction (r = −0.7439, P = 0.0055 for OFT; r = −0.7103, P = 0.0096 for EPM; r = −0.4615, P = 0.1309 for Y-maze; r = −0.6561, P = 0.0205 for NOR; Figs. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Cognitive Function Anxiety Depression Mechanism
32796318 Consistent with recent studies, PSNL mice with prolonged (6-month) mechanical hyperalgesia and cold allodynia showed both anxiety and depression in OFT, EPM, and TST tests, and working and recognition memory deficits in Y-maze and NOR tests. Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. Anxiety Depression Mechanism
30740905 The GB34 site is at the depression below the capitulum fibulae posterolateral to the knee joint. J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. Depression Mechanism
24908398 EA stimulation was provided at two acupoints: the experimental acupoint ST36 Zusanli (5 mm below head of fibula under the knee joint and 2 mm lateral to the anterior tubercle of the tibia) and a control acupoint SP9 Yinglingquan (in a depression anterior and inferior to the head of the fibula). BMC Complement Altern Med. 2014 Jun 7;14:186. doi: 10.1186/1472-6882-14-186. Depression Mechanism
32249904 Down-regulation of oxytocin protein has been reported to correlate with depression, insomnia and neural regulation. Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. Insomnia Depression Mechanism
32249904 PRELP (Prolargin) related to neural regulation, decreased prolactin is associated with depression and insomnia. Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. Insomnia Depression Mechanism
30089868 The present study investigated whether acupuncture improves depression- and anxiety-like behaviors induced using a single prolonged stress (SPS) as a PTSD rat model. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 We found that acupuncture at HT8 significantly alleviated both depression- and anxiety-like behaviors induced by SPS in rats, as assessed by the forced swimming, elevated plus maze, and open field tests; this alleviation was blocked by rapamycin. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 PTSD is often comorbid with depression and other anxiety disorders. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Several studies have substantiated its benefits for depression and anxiety. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 In addition, acupuncture is used for depression and anxiety, which are the most frequent complaints of psychiatric complaints in Complementary Alternative Medicine (CAM) clinic. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 In the SPS rat model, animals that were treated with predictable continuous trauma showed depression- and anxiety-like behaviors, which are psychological symptoms of PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Dysregulation of mTOR is implicated in the etiology of various psychiatric disorders, including depression. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 Previous studies showed a loss in mTOR signaling in the hippocampus of subjects with depression and anxiety disorders. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Stress is thought to induce changes in nerve cells and impair the number and function of synapses, leading to depression. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 This study investigated whether acupuncture has beneficial effects on the depression- and anxiety-like behaviors in the SPS rat model of PTSD using the forced swimming test (FST), open field test (OFT), and elevated plus maze (EPM) test. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 SPS-induced depression- and anxiety- like behaviors, and acupuncture stimulation in the rats. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 HT8 is located on the palm of the fore paw, in the depression between the fourth and fifth metacarpal bones, proximal to the fifth metacarpophalangeal joint and HT7 is located on the anteromedial aspect of the wrist, radial to the flexor carpi ulnaris tendon, on the palmar wrist crease. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 Effects of acupuncture at HT8 on depression- and anxiety-like behaviors and, blood levels of corticosterone and CRF expression in the PVN of the SPS model of PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 PTSD has diverse symptoms including depression and anxiety; therefore, this animal model was tested for two different behaviors simultaneously. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Effects of acupuncture at HT8 on depression- and anxiety-like behaviors in SPS-induced PTSD rats Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Effects of acupuncture at HT8 on depression- and anxiety-like behaviors and CRF expression in the PVN, and blood levels of corticosterone of the SPS model of PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 The SPS-induced groups displayed little variation in swimming time, indicating that the above results are caused by depression-like behavior, not by motor function deficits (Fig. 3D). Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Motor Function Mechanism
30089868 ), blocked depression- and anxiety- like behavior by acupuncture at HT8 in the hippocampus. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Taken together, these findings suggest that pretreatment with the mTOR inhibitor rapamycin significantly blocked the effect of HT8 on the depression- and anxiety-like behaviors. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Synaptic plasticity is involved in the pathogenesis of depression. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 Our findings show that depression- and anxiety-like behaviors in the SPS rat model of PTSD are alleviated by acupuncture at acupoint HT8, but not at other acupoints. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 To our knowledge, this study is the first to show the effects of acupuncture treatment on both depression- and anxiety-like behaviors and their underlying mechanism in the SPS-induced PTSD animal model. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 The SPS paradigm is considered to be an experimental model mimicking PTSD because it mirrors most of the neuronal deficits and psychological symptoms seen in patients with PTSD; depression- and anxiety-like behaviors are considered the main symptoms in the SPS-induced PTSD rat model. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 In this study, we found that SPS administration caused reduced time spent in the center of the OFT and in the open arms of the EPM, as well as increased immobility in the FST, reflecting characteristics of depression and anxiety that are frequent complaints in patients with PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
30089868 Forced maintenance of high corticosterone levels is associated with the stress response and subsequent depression- and anxiety-like behaviors in patients with PTSD. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Stress Response Anxiety Depression Mechanism
30089868 The mTOR signaling pathway is highly linked with hippocampal signaling in depression. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 Recent findings suggest that synaptic plasticity may play an important role in the neurobiology of depression and effects of antidepressant therapy. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 As reported for other rodent depression models, we observed that SPS decreased the phosphorylation levels of upstream proteins such as pAkt and pERK as well as mTOR and its downstream p4E-BP-1 and p70S6K in the hippocampus. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Blood Pressure Depression Mechanism
30089868 HT8 is located on the palm of the fore paw, in the depression between the fourth and fifth metacarpal bones, proximal to the fifth metacarpophalangeal joint. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 In order to evaluate depression severity, we performed a modified FST, according to the previously described method. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Depression Mechanism
30089868 of each measure, in each group) to enable the comparison between different measures that depict depression- and anxiety-like symptoms. Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. Anxiety Depression Mechanism
26792101 Stimulation of Yanglingquan (GB34), which is located at the depression anterior and inferior to the fibular head, is traditionally used for the motor function treatment in TCM. Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. Depression Motor Function Mechanism
26792101 GB34 is located at the depression anterior and inferior to the fibular head. Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. Depression Mechanism
29981376 These medications have poor efficacy for managing chronic pain and produce adverse side-effects, such as altered mental state, addiction, and life-threatening respiratory depression. J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. Side Effects Depression Mechanism
32956833 Additionally, some studies have shown that the modulation of SP binding to NK1R may be useful in the treatment of diseases, such as inflammatory conditions associated with the gastrointestinal tract, emesis, depression, cancer, and social anxiety disorder. Brain Behav Immun. 2021 Jan;91:683-694. doi: 10.1016/j.bbi.2020.08.016. Epub 2020 Sep 18. Gastrointestinal Tract Nausea and Vomiting Anxiety Depression Mechanism
29034548 It has further been shown that 2Hz EA induced long-term depression (LTD) of C-fiber-evoked potentials while 100 Hz EA induced long-term potentiation (LTP) in SNL rats. Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. Depression Mechanism
36003380 It contributed to neuroprotection against chronic unpredictable mild stress by enhancing brain-derived neurotrophic factor expression and improving hippocampal neurogenesis in a rat model of depression. Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. Neuroprotection Depression Mechanism
33384922 A low dose of ethanol can be a psychological stimulant, but a high dose causes depression and sedation and suppresses or impairs motor activity. Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. Depression Sedation Mechanism
33384922 Ethanol users commonly have comorbid affective disorders such as depression and anxiety. Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. Anxiety Depression Mechanism
33384922 Among acupuncture points, the Shenmen (HT7) acupuncture point is the source point of the heart meridian and has frequently been used to treat mental disorders, including drug addiction, anxiety, and depression. Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. Anxiety Depression Mechanism
33384922 In particular, the Sigma1 receptor (Sigma1 R) has been shown to play a role in learning and memory, responses to stress and depression, psychostimulant-induced sensitization, and vulnerability to addiction. Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. Learning and Memory Ability Depression Mechanism
38026466 The LEA group was acupunctured in bilateral EX-B2 (3 mm lateral to the depression below the spinous process of the C5 and C7 vertebrae) at a depth of 8 mm using aseptic acupuncture needles (Hanyi, Beijing Hanyi Medical Instruments Co., Ltd., China). J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. Depression Mechanism
38026466 In addition to undergoing the same acupuncture procedure as the LEA group, the IQAB group was acupunctured in bilateral BL17 (3 mm lateral to the depression below the spinous process of the T7 vertebra) at a depth of 6 mm and bilateral ST36 (posterolateral to the knee joint, 5 mm below the fibula capitulum) at a depth of 7 mm (Figure 2B). J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. Depression Mechanism
34782576 Following routine sterilization of the scalp and neck, a disposable aseptic acupuncture needle (φ 0.18 × 10 mm) was inserted at GV20 (located at the midpoint of the line connecting the tip of the mouse ear) with needle angle 15° to a depth of 2 to 3 mm and GV14 (located at the depression under the spinous process of the seventh cervical vertebra) with needle angle 45° to a depth of 2 to 3 mm (Figure 1) (Wang et al., 2014; Chang et al., 2018). Neural Regen Res. 2022 Jun;17(6):1310-1317. doi: 10.4103/1673-5374.327355. Depression Mechanism
34646326 The LI11 group received the same treatment at the LI11 point that was located at a depression anterior to the lateral aspect of the elbow. Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. Depression Mechanism
31217804 The rat GB34, which is determined according to the GB34 position in humans, is located at the depression anterior and inferior to the head of the fibula (Figure 1(b)). Evid Based Complement Alternat Med. 2019 May 14;2019:9512875. doi: 10.1155/2019/9512875. eCollection 2019. Depression Mechanism
30151295 Despite the significant progress in treating depression, novel treatments for depression with greater efficacy and fewer adverse effects are needed. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Adverse Reactions Depression Mechanism
30151295 However, little research on the topic of pharmacopuncture as a treatment for depression can be found in the literature. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 Pharmacopuncture treatment was performed at the GV14 (Dazhui) acupoint, which is located on the posterior midline in the depression below the spinal process of the 7th cervical vertebra, by using a 1-mL disposable syringe with a 30-gauge needle to slowly inject 200 μL of scolopendra extract into the mice in the experimental group. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 The tail suspension test (TST) and the forced swimming test (FST) were conducted to study the effects of scolopendra pharmacopuncture on depression. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 Increased immobile times on the TST and the FST reflect a state of despair as is often observed in cases of depression. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 The results of our study suggest that scolopendra pharmacopuncture may be a potential alternative therapy for patients suffering from depression. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 Previous studies have reported that acupuncture, electro-acupuncture, and moxibustion at GV14 (Dazhui) ameliorate the symptoms of depression. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 In this study, we injected purified scolopendra extract into the GV14 (Dazhui) site and found that treatment to be effective in treating depressive behavior in a mouse model of depression caused by stress due to chronic immobilization. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 Therefore, further research on the effects of scolopendra pharmacopuncture on pain control and depression management is warranted. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 Overall, this study suggests that scolopendra pharmacopuncture might be an effective alternative treatment for patients with depression, as well as for patients suffering with pain. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
30151295 The results suggest that scolopendra pharmacopuncture might serve as another potential therapy for patients with depression. J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. Depression Mechanism
34472492 Taichong acupoint is in the depression between the first and second metatarsals of the dorsal surface of the foot. Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. Depression Mechanism
24803946 The DU26 acupoint is located in the anterior midline and in the depression below the nose. Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. Depression Mechanism
24803946 DU16 is located in the posterior midline and in the depression below the spinous process of the second cervical vertebra in prone position (Figure 1). Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. Depression Mechanism
28672928 Such negative emotions as tension, worry, fear, depression and anxiety; and social environment, diet, daily life and movement conditions are external factors. Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. Anxiety Depression Mood Mechanism
23970931 ST36 is located at the proximal one-fifth point on the line from the depression lateral to the patella ligament to the anterior side of the ankle crease. Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. Depression Mechanism
38223807 The SP10 acupoint is located in the depression anterior and distal to the head of the fibula of mice. J Tradit Complement Med. 2023 Jul 20;14(1):91-100. doi: 10.1016/j.jtcme.2023.07.005. eCollection 2024 Jan. Depression Mechanism
25861363 Upregulation of Tph1 and downregulation of Olr883 indicated that the therapeutic effect of acupuncture for ischemic stroke may be closely related to the suppression of poststroke depression and regulation of olfactory transduction. Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. Depression Mechanism
25861363 19 pathways of downregulated mRNAs were examined including the regulation of calcium signaling pathway, gastric acid secretion, salivary secretion, axon guidance, hypertrophic cardiomyopathy, neuroactive ligand-receptor interaction, long-term depression, axon guidance, pancreatic secretion, and sphingolipid metabolism (see Table 5). Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. Depression Mechanism
25861363 This kind of amine metabolism closely related to the mechanism of poststroke depression. Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. Depression Mechanism
25861363 Depression is the most common symptom which increases the mortality, recurrence rate, and mobility of stroke patients. Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. Depression Mechanism
25861363 Our result of microarray analysis and RT-PCR result showed that the expression of Tph1 was increased after acupuncture treatment which indicated that acupuncture had a potential effect on poststroke depression by promoting the level of 5-HT in brain. Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. Depression Mechanism
25861363 Upregulation of Tph1 and downregulation of Olr883 after acupuncture treatment indicate that the therapeutic effect of acupuncture for ischemic stroke may be closely related to the suppression of poststroke depression and regulation of olfactory transduction. Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. Depression Mechanism
37066940 Our previous studies confirmed that PTSD model rats showed significant emotional disturbances, such as anxiety, depression, and fear, as well as obvious declines in learning and memory. Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. Learning and Memory Ability Anxiety Depression Mood Mechanism
37066940 One of the core PTSD symptom is the persistence of memories of the traumatic event that triggered PTSD (i.e., traumatic fear memory) . Recent studies have confirmed that acupuncture can suppress or eliminate fear memory  as well as improve sleep architecture, relieve depression, and alleviate spatial learning and memory deficits ; moreover, acupuncture has relatively long-term effects and few side effects. Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. Side Effects Learning and Memory Ability Depression Mechanism
28852400 In addition to cognitive impairment, a number of AD patients also suffer from behavioral and psychiatric symptoms, among which agitation and depression are the most common (Tsai et al., 2013). Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197. Depression Mechanism
25206746 Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Preliminary basic research and clinical findings have demonstrated that electroacupuncture therapy exhibits positive effects in ameliorating depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Electroacupuncture therapy alleviated depression-related manifestations in the model rats. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Real-time PCR showed that the genes Vgf, Igf2, Tmp32, Loc500373, Hif1a, Folr1, Nmb, and Rtn were upregulated or downregulated in depression and that their expression tended to normalize after electroacupuncture therapy. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 These results indicate that electroacupuncture at Baihui and Yintang modulates depression by regulating the expression of particular genes. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 There is strong evidence that abnormal gene expression in turn worsens the disease, and this vicious circle makes it difficult to cure conditions such as depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Recently, a large number of genes, such as the 5-hydroxytryptamine receptor, 5-hydroxytryptamine transporter, and tryptophan hydroxylase, have been found to be related to depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Depression is a complex, clinically common mental disorder, which involves various brain nuclei, multi-region neuronal associations, and diverse transmitters. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 A previous study found evidence for multiple gene imbalances in the brain of patients with depression, and proposed this as a pathological factor. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Various nerve cells and multiple brain functions lead to a complex interaction between gene expression and the clinical manifestations of depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Therefore, damage to hippocampal neuronal structure and function plays a key role in the onset of depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 There is strong ancient and modern evidence for the utility of electroacupuncture in the treatment of depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 A model of chronic unpredictable mild stress-induced depression was established in the latter two groups. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Electroacupuncture ameliorated the manifestations of depression in the model rats Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Electroacupuncture increased sucrose consumption in the depression model rats Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 However, after electroacupuncture, sucrose consumption was significantly increased in the depression model rats (P < 0.05; Table 3). Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Electroacupuncture shortened the time spent in an immobile state in the depression model rats Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Electroacupuncture influenced hippocampal depression-related gene expression in the depression model rats Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 A total of 21 genes (Table 5), Trim32, Tm2d1, Sumo2, Spcs2, Serinc3, Rtn4, Rnf103, Loc500373, Rnf103, RGD1311493, Psmd4, Ppap2a, Vgf, Tmp32, Nmb, Lsm8, Igf2, Hif1a, H3f3b, Gpm6b, Gng10, Folr1, and XM_231625 were identified to be differentially expressed in the hippocampus of the depression model rats compared with control rats. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Our present results suggest that (1) depression is attributable to comprehensive regulation of multiple hippocampal genes that are concerned with metabolism, signal transduction, and cell growth. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 In the diseased state, genes with altered expression are closely related to the pathological mechanism and are the main factors leading to depression; and (2) electroacupuncture can treat depression by modifying or regulating the expression of various genes. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The mechanism underpinning the effect of electroacupuncture on depression is related to gene regulation. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 These genes were significantly downregulated in depression and upregulated after electroacupuncture. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Recently, increasing attention has been paid to the role of the stress hypothesis in the onset of depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 According to the stress hypothesis, depression is caused by excessive stress mechanisms in the brain, in which the HPA axis plays a key role. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The HPA axis is considered the common pathway of many symptoms and signs of depression, and the stress hypothesis is opening new and exciting avenues for the treatment of this condition. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 In this study, we found that Trim32 expression was downregulated in depression and returned to normal after electroacupuncture. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Energy metabolism and nerve cell growth are both closely associated with depression, suggesting that Nmb is a depression-related gene that deserves further study. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Here, Igf2 gene expression decreased in the brain of depression model rats and its expression returned to normal after electroacupuncture. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 We found that expression of the related gene Loc500373 was decreased in the brain tissue of depression model rats. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 We demonstrated that Rtn4 expression was decreased in the brain tissue of depression model rats, indicating a deficit in protein biosynthesis. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 We found that Hif1a expression was downregulated in depression model rats, which would suggest a reduction in hippocampal nerve cell apoptosis. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Hif1a expression recovered after electroacupuncture, which suggests that it is a depression-related gene that warrants further study. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 We believe that these gene changes underlie the manifestations of depression in this model. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 This is highly important for maintaining tissue structure, restoring cell function, and alleviating the symptoms of depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The mechanism underlying the effect of electroacupuncture on depression relates to the regulation of multiple genes. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 This adds experimental evidence to the observed clinical effect of electroacupuncture on depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The function of these and other depression-related genes should be studied further. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 Establishment of a depression model in rats using chronic unpredictable mild stress Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 We established a rat model of chronic unpredictable mild stress-induced depression using a slight modification of the method of Willner. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The depression model rats were raised separately, one rat per cage. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 In accordance with The Rat Brain in Stereotaxic Coordinates, electroacupuncture at rat acupoints Baihui (the center of parietal bone) and Yintang (the middle point of the line between the brow bones) was performed from the day of establishing the depression model to day 21 of treatment. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 One day before the induction of depression and on day 21 of the treatment, rats were placed into the central square of an open-field apparatus. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The sucrose consumption test was performed 1 day before the induction of depression and on days 7, 14, and 21 of the treatment. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The forced swimming test was performed 1 day before the induction of depression and on days 7, 14, and 21 of the treatment. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
25206746 The rats were decapitated on day 21 after the induction of depression. Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. Depression Mechanism
36636219 However, these treatments have negative impacts on patient cognitive function and can cause addiction and central nervous system depression. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Cognitive Function Depression Mechanism
36636219 The Baihui point first seen in the ""Acupuncture and Moxibustion A and B Classic"" is located in the depression in the middle of the top of the head, 5 inches away from the front hairline. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Depression Mechanism
36636219 Long-term insomnia increases the incidence of hypertension, coronary heart disease, Alzheimer's disease, anxiety, depression, neurosis, menopausal syndrome, chronic indigestion, anemia, atherosclerosis and other related diseases and seriously affects human lifespan. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Insomnia Anxiety Depression Mechanism
36636219 People with insomnia are five times more likely to suffer from depression and anxiety than the general population, have a multiplied risk of cardiovascular disease, and have a significantly higher risk of death. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Cardiovascular Insomnia Anxiety Depression Mechanism
36636219 Our research has found that DHS can also reduce the release of the excitement monoamine neurotransmitters DA, NE, and EPI, which is similar to previous research on the treatment of depression rats. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Depression Mechanism
36636219 There is much evidence that experiencing psychological pressure will reduce the expression of BDNF, and a lack of neurotic nutritional support will lead to severe depression. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Depression Mechanism
36636219 CORT can induce depression and is involved in the occurrence and development of comorbidities of insomnia, anxiety and depression. Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. Insomnia Anxiety Depression Mechanism
32021397 GB34 is located in the depression anterior and distal to the head of the fibula of the rat. J Pain Res. 2020 Jan 13;13:75-86. doi: 10.2147/JPR.S225431. eCollection 2020. Depression Mechanism
32021397 A previous study found that cortical spreading depression-induced activation of pial and dural macrophages is more likely to increase inflammation in which meningeal nociceptors function. J Pain Res. 2020 Jan 13;13:75-86. doi: 10.2147/JPR.S225431. eCollection 2020. Depression Mechanism
37128191 Moreover, non-motor symptoms of PD, including anxiety, depression, and hyposmia, have been associated with impaired neurogenesis. J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. Anxiety Depression Mechanism
37128191 Under isoflurane (JW Pharmaceutical, Seoul, Korea) anesthesia, two sterilized stainless steel needles (0.18 mm × 8 mm; Dongbang Acupuncture Inc., Boryeong, Korea) were inserted to a depth of approximately 2 mm in each leg, one at GB34 (Yangneungcheon in Korean, Yanglingquan in Chinese; on the fibular aspect of the leg, in the depression anterior and distal to the head of the fibula) and the other at BL60 (Gollyun in Korean, Kunlun in Chinese; on the posterolateral aspect of the ankle, in the depression between the prominence of the lateral malleolus and the calcaneal tendon). J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. Depression Mechanism
37096024 Lee EJ, Warden S et al used serotonin or serotonin antagonists/agonists to investigate the mechanisms by which acupuncture improved multiple symptoms (eg, pain, obesity, and depression), which were confirmed to be relevant for alterations of serotonin levels. Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. Depression Mechanism
24527041 Importantly, the depression and anxiety that occur during morphine addition and morphine abstinence often lead to a relapse in humans. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 The depression and anxiety associated with morphine withdrawal can be alleviated by the administration of antidepressant or anxiolytic drugs such as fluoxetine or agmatine. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 A number of studies have found that acupuncture is an effective remedy for depression and anxiety and may be as effective as antidepressant drugs. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 In East Asian nations, acupuncture has been widely used as a therapeutic method to treat many psychosomatic disorders including major depression, stress, and drug abuse. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Depression Mechanism
24527041 As a comparable control acupoint, we also performed the stimulation to another acupoint, the TE5 acupoint, on a different (large intestine) meridian, and the triple-energizer channel, which is known to treat immune depression and pain/neuropathy of the arm. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Immunity Depression Mechanism
24527041 FST, a representative behavioral test for depression, is frequently used to evaluate the activities of potential antidepressant drugs in rodent models. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Depression Mechanism
24527041 Social interaction test has been pharmacologically validated as an experimental paradigm to measure depression or anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 During withdrawal for either 1 or 4 weeks following repeated exposure to chronic morphine, morphine-treated rats exhibit a significant depression-like phenotype or despair-like responses, characterized by an increased duration of immobility and decreased time of climbing behavior during the FST compared to the saline-treated controls (Figures 5(a) and 5(b)). Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Depression Mechanism
24527041 This finding suggests that acupuncture stimulation of SP6, but not of TE5 or the tail, significantly restores depression-like despair behavior. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Depression Mechanism
24527041 Many studies have shown that CRF levels are correlated with anxiety in animal models of depression, suggesting a possible link between high level expression of CRF and predisposition to anxiety or morphine withdrawal-induced depression. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 It has been proposed that clinical anxiety or depression may be the result of alterations in the activity of the LC in central noradrenergic system. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Moreover, in the present study, there was a decrease in the expression of BDNF mRNA in the rat hippocampus as well as an increase in depression- and anxiety-like symptoms following protracted abstinence from repeated morphine administration. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 For the past several decades, several antidepressants have been implicated in the alleviation of both types of illnesses such as depression and drug abuse. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Depression Mechanism
24527041 Thus, changes in depression- and anxiety-like behaviors may be observed 4 weeks after abstinence. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 The observed immobility behavior by rats in the FST is analogous to a state of lowered mood or helplessness and depression in humans. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Depression Mood Mechanism
24527041 Although the FST provides information about mood (i.e., depression and anxiety) in rodents, it is important to use caution when extrapolating the data to humans. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mood Mechanism
24527041 Anxiety is another complex feature of depression, and anxiety-like symptoms in chronically stressed animals are not surprising. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 The present data suggest that CRF circuits in the hypothalamus were potently activated by morphine administration, and this activation might be responsible for inducing depression and anxiety related to morphine withdrawal. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 TH is an enzyme involved in the response to morphine withdrawal-related psychopathological conditions, such as depression and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Therefore, the current results are consistent with previous reports indicating that depression- and anxiety-like behaviors induced by morphine withdrawal are the result of alterations in the central noradrenergic system. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Thus, acupuncture stimulation of SP6 is capable of attenuating complex behaviors associated with depression and anxiety via the modulation of the central noradrenergic system. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 In the present study, acupuncture stimulation of SP6 restored the decreased expression level of BDNF mRNA in the hippocampus and ameliorated depression- and anxiety-like behaviors in rats experiencing protracted abstinence from morphine administration. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 These results suggest that stimulation of the acupuncture point spreads throughout the body at a rapid rate and its effect is highly point specific, at least for modulating the depression- and anxiety-like symptoms associated with morphine discontinuation. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Currently, acupuncture is a relevant therapy in complementary and alternative medicine for managing various psychosomatic diseases such as drug abuse, stress, depression, and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Indeed, acupuncture stimulation leads to inhibition of CRF and TH, which are implicated in the etiology of depression. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Depression Mechanism
24527041 These results demonstrate that acupuncture stimulation of SP6 reduces the depression- and anxiety-like symptoms strongly associated with morphine abstinence, probably by modulating hypothalamic CRF and the noradrenergic system that underlies mood disruption. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mood Mechanism
24527041 This indicates that acupuncture stimulation of SP6 might be effective in preventing patients with drug addiction from relapsing into drug seeking while trying to quit, by relieving some of the discomfort of morphine withdrawal symptoms including depression and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Therefore, acupuncture stimulation may be a useful therapy in the development of alternative medicines for treating morphine withdrawal-related symptoms, such as depression and anxiety. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
24527041 Experimental schedule for study of morphine withdrawal-induced depression- and anxiety-like behaviors in rats. Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. Anxiety Depression Mechanism
28672900 5-HT in the dorsal raphe nucleus is involved in the effects of 100-Hz electro-acupuncture on the pain-depression dyad in rats Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 The pain-depression dyad is becoming widespread in the clinic and is attracting increasing attention. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 A previous study by our group found that 100-Hz electro-acupuncture (EA), but not 2-, 50- and 2/100-Hz EA, was effective against the reserpine-induced pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 The present study aimed to investigate the mechanism underlying the effects of 100-Hz EA on the pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 100-Hz EA alleviated the pain-depression dyad and upregulated 5-HT in the DRN of reserpine-injected rats. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 The present study was the first to demonstrate that 5-HT in the DRN is involved in mediating the analgesic and anti-depressive effects of 100-Hz EA on the pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 This finding provided a scientific basis for high-frequency EA as a potential treatment for the pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 The pain-depression dyad is characterized by widespread pain, tenderness to palpation and various concomitant symptoms, including affective disorders such as depression. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Researchers have begun to focus on non-pharmaceutical therapies such as music therapy and psychotherapy, in an attempt to identify an ideal and systemic therapy for the pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Low-frequency EA also effectively attenuates depression. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Considering that the pain-depression dyad is associated to lesions at the supraspinal level, it was hypothesized that low-frequency EA is also more effective than high-frequency EA in treating the pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 However, by comparing the effects of 2-, 50-, 100- and 2/100-Hz EA on the pain-depression dyad, a previous study by our group found that only 100-Hz EA effectively alleviated allodynia and depression. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Whether the serotonergic system in DRN is also involved in the effects of 100-Hz EA on the pain-depression dyad has remained elusive, which was therefore the focus of the present study. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Induction of the pain-depression dyad Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Behavioral tests of depression and associated emotional disorders Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mood Mechanism
28672900 Emotional behavior was quantified using the OF test and EZM test, which are generally used to evaluate depression and anxiety. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mood Mechanism
28672900 EA increases the PWT in rats with pain-depression dyad via 5-HT Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 EA reduces depressive-like behavior in rats with pain-depression dyad via 5-HT Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 EA reduces anxiety-like behavior in rats with pain-depression dyad via 5-HT Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 In certain rodent models of depression, anxiety-like responses are observed. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 To determine whether anxiety-like behaviors accompany the pain-depression dyad, rats were subjected to the EZM test. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 100-Hz EA significantly increased the number of entries in the open arms, stretching time and distance traveled in rats with pain-depression dyad (P<0.05, vs. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 EA increases 5-HT in the DRN of rats with pain-depression dyad Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 HPLC-ECD was adopted to determine the effect of 100-Hz EA on 5-HT levels in the DRN in rats with pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 EA enhances the number of 5-HT-immunoreactive cells in the DRN of rats with pain-depression dyad Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Immunity Depression Mechanism
28672900 Bregma −8.0 mm was therefore determined to be the optimal location for examining the effect of 100-Hz EA on 5-HT-immunoreactive cells in the DRN of rats with pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Immunity Depression Mechanism
28672900 Pain-depression dyad is a complex illness with symptoms of pain overlapping with emotional disorders such as depression and anxiety. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mood Mechanism
28672900 It has been reported that 52% patients with chronic pain suffer from depression, which is a costly health problem. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 A previous study by our group initially demonstrated that EA with high frequency but not low frequency effectively relieves pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Several modeling methods are used for studying the mechanisms of the pain-depression dyad, including nerve injury, stress load and administration of reserpine, monosodium iodoacetate and Freund's complete adjuvant. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Reserpine-injected rats, an ideal model of pain-depression dyad, display hyperalgesia, allodynia and depressive behaviors accompanied with anxiety. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 The response is also similar to that of pain-depression patients in the clinic. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Considering that the forced swimming test can influence pain sensitivity in rodents, the present study used the OF test to evaluate depressive behaviors in rats with reserpine-induced pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 As the reserpine-injected rats exhibited not only depressive-like but also anxiety-like behavior in the EZM test, it was indicated that the pain-depression dyad model was successfully established. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Anxiety Depression Mechanism
28672900 However, the mechanism underlying the effects of EA on the pain-depression dyad has been rarely assessed. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 In the present study, 100-Hz EA upregulated 5-HT DRN in rats with reserpine-induced pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 These findings suggested that 100-Hz EA improves reserpine-induced pain-depression dyad partially via 5-HT DRN. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 In conclusion, the present study was the first, to the best of our knowledge, to demonstrate that 5-HT in the DRN participates in mediating the effects of 100 Hz EA on the pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Effects of EA on the PWT in rats with pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Effects of EA on (E) movement time, (F) mean speed and (G) distance traveled by rats with pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
28672900 Effects of EA on (E) entries in the open arms, (F) stretching time and (G) distance traveled of rats with pain-depression dyad. Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. Depression Mechanism
18830446 In horses, the side effects are protrusion of the penis and cardiorespiratory depression, leading to hypotension which is the main limitation for its use. Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. Side Effects Depression Mechanism
18830446 As expected, the reduction in respiratory rate was observed in horses treated with 0.1 mg kg−1 of Acp s.c., indicating that decreased respiratory rate was produced either by sedation or by a respiratory depression. Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. Depression Sedation Mechanism
18830446 Both aquapuncture (Sal-GV1) and pharmacopuncture (1/10Acp-GV1) produced signs of sedation without respiratory depression. Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. Depression Sedation Mechanism
26561562 In the rats, LI11 was located at a depression anterior to the lateral aspect of the elbow, and was needled perpendicularly. Acupunct Med. 2016 Jun;34(3):194-200. doi: 10.1136/acupmed-2015-010897. Epub 2015 Nov 11. Depression Mechanism
28837077 A case study from Japan describes the successful treatment of an 81-year-old woman with PD who received manual acupuncture treatment five days per week based on TCM principles for the relief of non-motor symptoms (hot flashes and paroxysmal sweating, depression and anxiety), using the LR3, LI4, KI5, KI7, SP6, GB34, BL18, BL15, and GB20 acupuncture points. Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. Anxiety Depression Mechanism
24757373 The SP9 acupoint is located in a depression between the posterior border of the tibia and the gastrocnemius muscle near the knee joint or the inferior border of the medial condyle of the tibia. Korean J Physiol Pharmacol. 2014 Apr;18(2):121-7. doi: 10.4196/kjpp.2014.18.2.121. Epub 2014 Apr 3. Depression Mechanism
20981331 AC has been used for a variety of medical conditions in both adults and children: pain relief, nausea and vomiting, drug addiction, stroke rehabilitation, depression, irritable bowel syndrome, and asthma, to name a few. Evid Based Complement Alternat Med. 2011;2011:606514. doi: 10.1155/2011/606514. Epub 2010 Sep 30. Pain Relief Nausea and Vomiting Depression Mechanism
20981331 Taichong (LR3) is on the dorsum of the hind limb, in the depression distal to the junction of the first and second metatarsal bones. Evid Based Complement Alternat Med. 2011;2011:606514. doi: 10.1155/2011/606514. Epub 2010 Sep 30. Depression Mechanism
35003293 In the acupuncture-related groups, acupuncture was performed on the acupoint Dubi which is located in the depression lateral to the patellar ligament and on the acupoint Zusanli which is located 3 cun lower than the Dubi (16 cun equal to the distance between the knee joint and the external ankle). Evid Based Complement Alternat Med. 2021 Dec 31;2021:2470182. doi: 10.1155/2021/2470182. eCollection 2021. Depression Mechanism
37383281 Some patients also have anxiety, depression, and other negative psychological emotions. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Anxiety Depression Mood Mechanism
37383281 Clinical studies have found that acupuncture at Back-Shu point has an excellent therapeutic effect on insomnia, effectively improving depression, anxiety, memory loss, immunity decline and other clinical symptoms caused by insomnia. World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. Immunity Insomnia Anxiety Depression Mechanism
35251208 Unlike general stress, PTSD causes fear memory disorders to appear even in safe situations when the traumatic event has disappeared; it can cause serious pathological changes such as anxiety disorders, depression, flashbacks, and cognitive memory dysfunction. Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. Anxiety Depression Mechanism
27594888 Generally, it is common to use drugs for FGID including antacids, prokinetic agents, antianxiety or antidepression drugs, digestants, and anti-HP treatment. Evid Based Complement Alternat Med. 2016;2016:1935372. doi: 10.1155/2016/1935372. Epub 2016 Aug 3. Anxiety Depression Mechanism
31737064 EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Visceral hypersensitivity is the main performance of IBS, which is associated with anxiety, depression, etc.. Furthermore, the latest release of Rome IV suggests that the pathogenesis of IBS is mainly due to disorders of gut-brain interaction. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Accumulating evidence has shown that CRF, which is mainly produced in the hypothalamic paraventricular nucleus, can induce altered bowel habits, visceral hypersensitivity, and emotional disorders, such as anxiety-like or depression-like behaviours, by combining with central CRF-R1. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mood Mechanism
31737064 Behavioural Assessment of Anxiety-Depression Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Effect of EA on Anxiety and Depression-Like Behaviours Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 Additionally, 20% to 60% of IBS patients have mental disorders such as anxiety and depression, which are positively correlated with IBS. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 As for mental disorders, rats' anxiety-like behaviours were evaluated by OT% of EMPT and depression-like behaviours by SP%. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 As a result, EA may be superior to PB in improving depression-like behaviours, although there was no significant difference between the two treatments. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Depression Mechanism
31737064 This result is consistent with the following finding: EA can enhance the SP% of depressing rats and relieve rats' anxiety and depression-like behaviours, with a similar effect to PB, an antidepressant medicine. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
31737064 As a result, EA was effective in downregulating CRF-R1 expression in the hypothalamus and IMMC, decreasing the expression of hypothalamus CRF, alleviating rats' visceral hypersensitivity and anxiety and depression-like behaviours, and meeting with Wu HG's research. Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. Anxiety Depression Mechanism
33229729 In addition, the early occurrence of non-cognitive and behavioral symptoms in prodromal AD, such as depression and general disturbances in mood (Chen et al., 2000; Wu et al., 2003), suggests the involvement of the DRN in AD. Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. Depression Mood Mechanism
33229729 A recent study demonstrated that neurons in the median raphe expressing vesicular glutamate transporter 2 project to both the lateral habenula and medial ventral tegmental area, and activation of these neurons induces depression-related anhedonia and fear memory acquisition (Szőnyi et al., 2019). Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. Depression Mechanism
31785199 Depression is a major mood disorder. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mood Mechanism
31785199 This study aimed to investigate the effects of acupuncture on behaviors associated with depression in the chronic unpredictable mild stress (CUMS) rat model. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Rat behaviors associated with depression were tested using the sucrose preference test (SPT), the open field test (OFT), and the elevated plus maze (EPM) test. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Acupuncture reversed the behaviors associated with depression in the CUMS rat model and reduced the expression of components of the NO and cGMP pathway in the rat hippocampus and plasma. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 In the CUMS rat model, treatment with acupuncture reduced behaviors associated with depression, and these effects were associated with changes in the NO and cGMP signaling pathway. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Depression is a mood disorder characterized by a persistent depressed mood, a feeling of helplessness, and can be associated with anxiety. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Anxiety Depression Mood Mechanism
31785199 Severe depression can be associated with symptoms of delusion, including hallucinations, and suicidal thoughts. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Chronic depression impairs quality of life. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Therefore, new and safer approaches to the treatment of depression are needed. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Acupuncture is a traditional Chinese medicine that is effective in some cases of clinical depression and has few side effects. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Side Effects Depression Mechanism
31785199 However, the mechanisms for the effects of acupuncture in the treatment of depression remain to be determined. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Previous studies have shown that the nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) signaling pathway of the central nervous system has a role in depression and other mental disorders. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 These changes associated with the NO-cGMP signaling pathway is associated with depression. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Previous studies have shown that the mechanism of the effect of acupuncture on depression may be related to the NO-cGMP pathway. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Recent clinical research also supports the therapeutic effects of acupuncture in patients with depression and other psychiatric illnesses. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Therefore, this study aimed to to investigate the effects of acupuncture on behaviors associated with depression in the chronic unpredictable mild stress (CUMS) rat model. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 The use of this rat model in the evaluation of behavior that may be associated with depression has been supported by previous studies. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 The findings from this study showed that prolonged acupuncture treatment reduced behaviors in the CUMS rat model that may be associated with depression, as shown by increased sucrose consumption in the SPT, the scores from the OFT, and the behavior scores from the EPM test, which are supported by findings from previous studies. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Previous studies have shown that NO-cGMP signaling may be involved in depression. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 The central neurotransmitter, dopamine, which has a role in depression, is also dependent on cGMP levels. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 The overexpression of cGMP can mediate protein phosphorylation to produce physiological and pathological effects, damage DNA and neurons, which may lead to depression. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 Therefore, the NO-cGMP signaling pathway may be associated with synaptic plasticity of neurons in the brain, and with the occurrence of depression and other mental disorders. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 treated patients with anxiety and depression following an acute stroke with acupuncture of the 13 ghost acupoints and showed a significant improvement in symptoms. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Anxiety Depression Mechanism
31785199 Although the CUMS rat model is well-established, it is an animal model, and caution should be used when extrapolating the findings from an animal study to a chronic and complex human disease, such as depression. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 In this study, although the whole rat brain was removed, only the rat hippocampus was studied, as this was assumed to be an important brain area associated with depression. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 However, the pathophysiology of clinical depression involves several brain regions. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 In this study, the NO-cGMP signaling pathway was studied, but clinical depression involves several genes and molecular pathways that have yet to be investigated in this animal model. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 This study aimed to investigate the effects of acupuncture on behaviors associated with depression in the chronic unpredictable mild stress (CUMS) rat model. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31785199 In the CUMS rat model, treatment with acupuncture reduced behaviors associated with depression, and these effects were associated with changes in the NO and cGMP signaling pathway. Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. Depression Mechanism
31045558 According to the relevant data of the behavioral test, it can be known that the two modeling methods can obviously induce anxiety, depression and fear-like behaviors and can significantly reduce spatial learning and memory ability in rats. Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. Learning and Memory Ability Anxiety Depression Mechanism
33791033 For applications in the Hou Hai acupoint, located in the depression between the average distance from the base of the tail (coccygeal muscle) to the anal sphincter with innervation in the caudal rectal nerve, a 1mL syringe was used, coupled to a 16G catheter, inserted in an angular position of 45°, with a 45mm depth (catheter's size). Anim Reprod. 2020 Nov 25;17(4):e20200554. doi: 10.1590/1984-3143-AR2020-0554. Depression Mechanism
32042305 Two acupoints, Zusanli (ST36, located at one-fifth point below and lateral to the anterior tubercle of the tibia) and Kunlun (BL60, located at the depression posterior to the lateral malleolus of tibiofibula), were commonly used for EA treatment of cancer pain in animal studies (Fig. 1a). Chin Med. 2020 Feb 4;15:13. doi: 10.1186/s13020-020-0289-y. eCollection 2020. Cancer Pain Depression Mechanism
20953422 The locations of the acupoints were illustrated in Figure 1; that is, GB39 is located at the distal 4/5 point on the line connecting the lateral side of the knee and the lateral malleolus of the tibiofibula, BL23 at the depression lateral to the lower border of spinous process of the second lumbar vertebra, and ST36 at the proximal 1/5 site of craniolateral surface of the leg distal to the head of the tibia in a depression between the muscles of the cranial tibia and the long digital extensor. Evid Based Complement Alternat Med. 2011;2011:290489. doi: 10.1155/2011/290489. Epub 2010 Sep 14. Depression Mechanism
22110373 The SP9 point is located in the inferior border of the medial condyle of the tibia, in the depression between the posterior border of the tibia and gastrocnemius muscle on the medial leg. Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. Depression Mechanism
22110373 The ST36 point is located one fingerbreadth lateral to the tibia's anterior crest, 9.0909 cm (3 cun : 1 cun = 3.0303 cm) inferior to ST 35 in the depression to the lateral side of the patella on the leg. Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. Depression Mechanism
22110373 Our results showed the depression of p35 expression until 4 weeks after STZ injection and p35 cleavage to p25 at 4 weeks after STZ injection. Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. Depression Mechanism
22110373 demonstrated that MK-801 blocked the 2-Hz EA-induced spinal long-term depression of C-fiber-evoked potentials in spinal nerve ligation-induced neuropathic pain model. Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. Neuropathic Pain Depression Mechanism
37179843 Acupuncture Alleviates CUMS-Induced Depression-Like Behaviors by Restoring Prefrontal Cortex Neuroplasticity Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 To explore the therapeutic efficiency of acupuncture and the related molecular mechanism of neural plasticity in depression. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Chronic unpredictable mild stress- (CUMS-) induced rats were established for the depression animal model. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Our study provides new insights into the antidepressant approach, and further studies are warranted to elucidate the mechanisms of acupuncture involved in depression treatment. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Depression is a common chronic neurological disease with typical manifestations in modern society, including low self-esteem, helplessness, and anhedonia. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 According to the latest analysis of the World Health Organization's survey, more than 300 million people have suffered from severe depression worldwide and the growth rate was about 18% in the last decade. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Moreover, depression contributes to devastating mental trauma, brings pathophysiological disorders, and enhances susceptibility to some systematic diseases, such as cerebrovascular and cardiovascular diseases. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Cardiovascular Depression Mechanism
37179843 Unfortunately, there are no completely effective therapeutic approaches for depression to date; the currently available antidepressant strategies such as medications, psychotherapies, or others have limited efficacy and significant side effects during the treatment period. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Side Effects Depression Mechanism
37179843 Therefore, it is profoundly significant to investigate the pathophysiology of depression, developing new approaches and insights for clinical practice. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Previous studies have demonstrated that depression can induce long-term neural plasticity changes in some specific brain regions, and the recovery of neurogenesis and synaptic plasticity are strongly related to the prognosis of depressive patients. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Moreover, researchers have scientifically proven acupuncture to be one of the effective therapies for depression, which was frequently applied in China, the US, the UK, Japan, and Korea. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Acupuncture is a vital component of Oriental medicine, and it has been proven to promote the impairment of neural plasticity and relieve the symptoms of depression patients. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 However, the specific underlying mechanism of acupuncture in depression treatment remains elusive. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Acupuncture can interfere with the progression of depression by ameliorating neural plasticity; however, the relationship between acupuncture and neural plasticity-related proteins in the prefrontal cortex is still unknown. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 In this study, we intend to explore the antidepressant mechanism underlying acupuncture based on the neuroplasticity and its neural plasticity-related proteins BDNF/PSD95/SYN/PKMZ in the prefrontal cortex of chronic unpredicted mild stress- (CUMS-) induced depressed rats, providing prospective insights for the treatment of depression in the clinic. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Fluoxetine is the first particular serotonin uptake inhibitor that helps alleviate the manifestations of depression in the clinic. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 According to previous literature, the depression model has been initially formed in 21 days (former 3 weeks). Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Acupuncture Alleviates the Manifestations of Depression in CUMS-Induced Rats Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Depression is a chronic and recurrent disease, with a high prevalence rate worldwide. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Recently, acupuncture, a traditional Chinese medicine therapy, has been proven effective and safe in depression treatment by several clinical meta-analyses. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Nevertheless, the underlying mechanism of acupuncture in depression treatment is still unclear. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Our results demonstrated the depression-like behavior induced by CUMS procedure, while this behavior could be partly reversed by acupuncture treatment. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Besides, acupuncture had a similar and safer antidepression therapeutic effect as fluoxetine intervention. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Acupuncture has been identified as a safe and effective alternative therapy for depression with fewer side effects. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Side Effects Depression Mechanism
37179843 Therefore, the acupoints of PC7 and DU23 were elected in our study to treat the depression model rats. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 There have been many studies about acupuncture's effect on depression. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 However, few studies clarified the possible molecular mechanisms of the hypothalamic-pituitary-adrenal axis based on acupuncture involved in depression treatment. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 The structural and functional changes of neural cells in response to various stimuli are known as neural plasticity, including depression. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Previous studies have demonstrated that the biological mechanism of depression is associated with neural plasticity in specific brain areas, especially the prefrontal cortex. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 The functional synapses in the central nervous system were disarranged in depression patients by emotional disorder and stress. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mood Mechanism
37179843 It has been observed that chronic and repetitive stress can aggravate the manifestations of depression through the impairment of neural plasticity. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Intriguingly, acupuncture or fluoxetine treatment could significantly reverse these detrimental effects, which provide a new insight into potential acupuncture applications in depression treatment. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 The abnormal expression levels of functional proteins are closely related to depression susceptibility, including brain-derived neurotrophic factor (BDNF), postsynaptic density 95 (PSD-95), synaptophysin (SYN), and protein kinase M zeta (PKMZ). Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Altogether, CUMS-induced rats can be served as a reliable depression animal model, and acupuncture is effective and safe for ameliorating depression-like behavior, increasing cells number, prolonging the length of the dendrites, and enhancing the spine density in CUMS-induced rats. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Further studies are warranted to elucidate the mechanisms of acupuncture involved in depression treatment. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 In this study, we revealed that acupuncture can play an antidepressant effect in CUMS-induced depression model rats. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
37179843 Schematic diagram of the mechanism by which acupuncture alleviates depression-like behavior in CUMS rats. Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. Depression Mechanism
27381504 Moreover, this chronic pain is associated with fatigue, depression, memory problems, anxiety, sleep disturbances, and headaches. Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. Insomnia Anxiety Depression Mechanism
27381504 In contrast, induction of long-term depression (LTD) in the SC dorsal horn can reduce pain. Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. Depression Mechanism
26770252 Anxiety and depression often coexist with persistent pain. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Depression Mechanism
26770252 In humans, patients with persistent pain frequently suffer from a series of aversive emotions including anxiety, fear, depression, loneliness, and misanthropy, which can be more distressing than the pain itself. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Anxiety Depression Mood Mechanism
26770252 In 1996, the World Health Organization conference in Milan suggested 64 indications for acupuncture, including many psychiatric disorders such as cardiac neurosis, depression, and schizophrenia. Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. Depression Mechanism
29311503 In humans, ST35 is located in the depression lateral to the patellar ligament. Exp Anim. 2018 May 10;67(2):271-280. doi: 10.1538/expanim.17-0142. Epub 2018 Jan 1. Depression Mechanism
34039946 Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Acupuncture, which has many good effects and few adverse effects, is widely recognized as an alternative therapy for depression in clinical practice. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Adverse Reactions Depression Mechanism
34039946 Our experimental results indicate that acupuncture can alleviate depression-like performance in CUMS rats by regulating intestinal microbes and neurotransmitters. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Depression is an affective disorder characterized by persistent sadness, feelings of inferiority and helplessness, and anxiety. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Anxiety Depression Mechanism
34039946 According to the latest data from the World Health Organization, there are more than 300 million people with depression in the world. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Depression has become one of the main causes of human health problems worldwide. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Antidepressants are the dominant form of clinical treatment for depression, and they include selective serotonin reuptake inhibitors, particularly fluoxetine. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Acupuncture is an alternative therapy for depression, with fewer adverse effects and good therapeutic efficacy, as well as a low financial burden. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Adverse Reactions Depression Mechanism
34039946 As a widely used alternative therapy, acupuncture for the treatment of depression has increasingly attracted attention in clinical and animal experimental research. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Some researchers suggest that the ability of acupuncture to regulate depression may be related to the corticostriatal reward circuit in the brain. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Studies on acupuncture in rat models of depression have shown that its effect on depression-like behavior may be associated with the hypothalamus-pituitary-adrenal axis. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Studies have also shown that intestinal microbiota can play an important role in the pathogenesis and treatment of depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 For example, continuous administration of Lactobacillus rhamnosus for 4 weeks improved the anxiety and depression-like behavior of mice. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Anxiety Depression Mechanism
34039946 Whether intestinal microbes have a role in the mechanism of acupuncture treatment for depression remains unclear. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Based on previous experiments and the literature, we explored whether acupuncture at the Shangxing and Daling acupoints could have an antidepression effect through regulation of intestinal microbes and neurotransmitters. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 The CUMS model, which was originally developed by Paul Willner, is widely used in the experimental study of depression in animals. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 The first time was in the first week before CUMS modeling, and we used the results to exclude rats with different baselines or congenital depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 The open-field test can be used to detect spontaneous activity and depression-like behavior of rats. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 The ratio of Bacteroidetes/Firmicutes has been considered to be an important indicator that is positively correlated with depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 The purpose of this study was to explore the mechanism of acupuncture in regulating depression in CUMS model rats. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 CUMS is widely used as a rodent depression model. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 We previously carried out studies to confirm that acupuncture can reverse behavioral changes in depression model rats, affect the nitric oxide-cyclic guanosine monophosphate signaling pathway, and have an antidepressant effect. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 We created a rat model of depression through CUMS standard procedures and established the effectiveness of the model through open-field and sucrose preference tests. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 These tests mainly assess core symptoms of depression, such as lack of pleasure. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Low levels of DA or 5-HT have been proved to be connected with depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Our experimental results are consistent with the current evidence that 5-HT can alleviate depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 AP can significantly increase the content of 5-HT in the brain hippocampus and the serum of depression model rats, and AP upregulated the content of BDNF/NMDAR and the mRNA of BDNF/NMDAR in the hippocampus tissue of depression model rats. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Intestinal microflora disorders have been shown to be important factors associated with depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Decreased fecal flora diversity has been observed in patients with depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 Our study suggests that acupuncture can reduce depression behavior in CUMS rats by regulating intestinal microbes. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 According to the bioinformatics analysis of 16S rDNA sequencing, the abundance of intestinal microbes in CUMS depression model rats decreased, and acupuncture regulated the changes of intestinal microbial diversity induced by CUMS. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 A recent study showed that the ratio of Firmicutes/Bacteroidetes in the intestines of patients with depression is increased. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 According to the KEGG enrichment analysis, we found that compared with the CUMS group, the AP group had improvements in the related pathways of cell growth, apoptosis, and metabolism, which can affect the brain-gut axis and improve depression-like behavior. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 The present study provides new insights into the treatment of depression. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
34039946 In conclusion, our research shows that acupuncture can reverse depression-like behavior in CUMS model rats. Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. Depression Mechanism
37384285 TRPV1 channels play a major role in various disorders, such as pain, depression, stress, obesity and anxiety, and are known to be involved in various acupuncture effects. Front Neurol. 2023 Jun 13;14:1168012. doi: 10.3389/fneur.2023.1168012. eCollection 2023. Anxiety Depression Mechanism
38164490 Chronic extensive pain is the main syndrome upsetting individuals with fibromyalgia (FM), accompanied by anxiety, obesity, sleep disturbances, and depression, Transient receptor potential vanilloid 1 (TRPV1) has been reported to transduce inflammatory and pain signals to the brain. Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. Insomnia Anxiety Depression Inflammatory Pain Mechanism
38164490 The beneficial effects of acupuncture in FM extend to its capacity to diminish anxiety, depression, and sleep disturbance. Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. Insomnia Anxiety Depression Mechanism
38164490 FM is a chronic pain accompanied by complicated symptoms such as anxiety, exhaustion, sleep disruption, and depression. Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. Anxiety Depression Mechanism
36277498 Trigeminal neuralgia (TN), one of the most severe and debilitating chronic pain conditions, is often accompanied by mood disorders, such as anxiety and depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuralgia Anxiety Depression Mood Mechanism
36277498 TN is a chronic neuropathic pain which often causes mood disorders, such as anxiety and depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuropathic Pain Anxiety Depression Mood Mechanism
36277498 An EA needle (0.18 × 13 mm, Suzhou Huatuo Medical Supplies Co., Ltd., Jiangsu, China) was used to puncture obliquely the Baihui (GV20, located in the middle of the parietal bone) and Xiaguan (ST7, located in the depression between the preauricular and mandibular notch) acupoints. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Depression Mechanism
36277498 Chronic pain can cause emotional disturbances like anxiety, depression, and fear in affected patients. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Depression Mood Mechanism
36277498 Thus, it adds to the probability of inducing mood disorders, including anxiety and depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Depression Mood Mechanism
36277498 Behavioral symptoms of anxiety and depression are closely related to the decrease in hippocampal volume and synaptic loss. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Anxiety Depression Mechanism
36277498 Some previous studies demonstrated that EA attenuates neuropathic pain and depression by improving the synaptic plasticity of spinal cord and hippocampus. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuropathic Pain Depression Mechanism
36277498 Furthermore, dendritic spine loss and atrophy of hippocampal neurons may have a key role in the pathogenesis of depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Depression Mechanism
36277498 Pathological changes in synapses are frequently seen in neuropathic pain and depression, including an abnormal synaptic density, reduced PSD and associated proteins, shortened active zone length, decreased curvature of the synaptic interface, and widened synaptic cleft. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Neuropathic Pain Depression Mechanism
36277498 These results are consistent with findings of other studies on the mechanisms of drugs used to treat pain and depression. Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. Depression Mechanism
25206816 In accordance with the Acupuncture Atlas in Rats, acupuncture at Baihui (on the head, the midpoint of the anterior hairline, at the midpoint of the line connection the apexes of both ears) and Dazhui (on the posterior median line, in the depression below the spinous process of the 7th cervical vertebra) was conducted using a 25 mm stainless steel acupuncture needle (0.30 mm diameter, 25 mm long; Suzhou Medical Sino-foreign Joint Venture, Suzhou, Jiangsu Province, China) at an angle of 30° and with a depth of 12 mm. Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. Depression Mechanism
34393735 Depression is a mood disorder characterized by disordered affect, thoughts, cognition, and behavior. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mood Mechanism
34393735 Antidepressant therapy is often the primary treatment for depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Therefore, some patients are seeking alternative treatments for depression, such as acupuncture. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 However, there are many unclear points regarding the mechanism of the effect of acupuncture on depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 In recent years, we have reported that acupuncture improves the symptoms of mild depression induced by water-immersion stress in a rat model and depression induced by forced swimming in a mouse model. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 In this study, we examined the effect of acupuncture on the symptoms of social defeat stress (SDS)-induced depression in mice that most closely resemble human symptoms. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 To examine the mechanism of the preventive and therapeutic effects of acupuncture on depression model mice, we examined the expression of neurotrophic factors in the brains of SDS mice. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Furthermore, the effects of acupuncture on the expression of neurotrophic factors appear earlier than those of antidepressants, suggesting that it may be a useful treatment for depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 According to a survey conducted in 2017, depressive disorder is a common mental illness affecting more than 300 million people of all ages worldwide (WHO Fact Sheet 2017 on Depression). Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Depression is a mood disorder characterized by disordered affect, thoughts, cognition, and behavior. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mood Mechanism
34393735 Social loss due to depression is widespread as it may cause suicide and obstacles in work and school. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Depression is commonly treated with psychotherapy, antidepressant therapy, and/or electroconvulsive therapy. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Antidepressant therapy is often the primary treatment for depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 In addition, about one-third of patients are known to have treatment-resistant depression to multiple antidepressants. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Therefore, some patients are seeking alternative treatments for depression, such as acupuncture therapy. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 However, there are many unclear points regarding the mechanism of the effect of acupuncture on depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Animal studies are commonly used in depression research, but few have investigated the effects of acupuncture on depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Social defeat stress (SDS) in mice has been developed as a new ethological model of depression that more closely models the psychological stress that humans can experience during antagonistic social interactions. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Since the SDS-induced depression model is caused by mental stress due to competition and defeat between individuals, it is considered that the SDS model reproduces human depression more than the previous animal models. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 In this study, we examined the effects of acupuncture on the suppression of depressive-like symptoms in an SDS-induced depression mouse model that is attacked by other animals to mimic the mental stress response that would occur in a more natural environment. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Stress Response Depression Mechanism
34393735 Depression-like symptoms were assessed by measuring changes in immobility time using the forced swimming test (FST), which is used as a screening test for antidepressants. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Many studies have been conducted on the mechanisms of depression development in humans and animals. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Focusing on these neurotrophic factors, we investigated the therapeutic mechanism of acupuncture in SDS-induced depression model mice. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 The development of depression symptoms in mice induced by SDS were suppressed by acupuncture. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 (A) Weight changes and (B) immobile time in the forced swimming test in mice during treatment of depression induced by SDS stress. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 To analyze the preventive effects of acupuncture on immobility induced by SDS, we examined the mRNA expression of neurotrophic factors in the brains of SDS mice with ongoing symptoms of depression by RT-PCR and real-time PCR. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 (A) mRNA expressions of neurotrophic factors in the brain of SDS mice with ongoing symptoms of depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 (B) mRNA expressions of neurotrophic factors in the brain after treatment of depression in SDS mice. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 mRNA expressions of neurotrophic factors in the brain of SDS mice with ongoing symptoms of depression quantified by real-time PCR. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 mRNA expressions of neurotrophic factors in the brain after treatment of depression in SDS mice quantified by real-time PCR. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 In the brain of SDS mice with ongoing symptoms of depression, NGF protein levels were significantly enhanced [F(3, 28) = 4.619710, p = 0.0095] (Control vs. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Expressions of neurotrophic factors in the brain of SDS mice with ongoing symptoms of depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Expressions of neurotrophic factors in the brain after treatment of depression in SDS mice. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Many animal studies have examined the state of depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 We have reported that simultaneous acupuncture stimulation as part of GV20 and Ex-HN3 improves the symptoms of a rat model of water-immersion-induced depression and a mouse model of FS-induced depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 In this study, we examined the effect of simultaneous acupuncture stimulation as part of GV20 and Ex-HN3 using SDS-treated mice that has been developed as a new ethological model of depression that more closely models the psychological stress that humans can experience during antagonistic social interactions. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 The results of our study showed that simultaneous acupuncture stimulation of GV20 and EX-HN3 can be used not only as a treatment for depression that has already developed, but also as a routine maintenance to avoid depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Various theories have been proposed as the causes of depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Recently, it has been proposed that decreased neurotrophic factor production, increased glutamate-induced intracellular calcium concentration, and abnormal intracellular signal transduction mechanisms related to neuroplasticity by cortisol via the hypothalamic-pituitary-adrenocortical (HPA) axis are also thought to be the cause of depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 In this study, we focused on the expression of neurotrophic factors in the brain, which are key components of depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 To examine the mechanism of preventive and therapeutic effects of acupuncture on depression, we examined the expression of neurotrophic factors in the brains of SDS mice. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 The relationship between stress that causes depression and neurotrophic factors has been identified. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Unlike NGF and BDNF, there are not many studies currently examining NT-3 and NT-4/5 in depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 examined the expression of NGF, BDNF, NT-3, and NT-4/5 mRNAs in peripheral blood cells of patients with depression and bipolar disorder. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 There are even fewer studies on the role of NT-4/5 in depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 Contrary to our results in SDS, some studies have reported reduced NGF expression in depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
34393735 As described above, improvements in the production of monoamine and serotonin, the HPA axis, and expression of neurotrophic factors have been proposed as treatments for depression. Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. Depression Mechanism
29636708 Sensitive and stable biomarkers that facilitate depression detection and monitor the antidepressant efficiency are currently unavailable. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The depression rat model was imitated by social isolation and chronic unpredicted mild stress (CUMS). Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Collectively, the antidepressant effect of acupuncture might be mediated by regulating the DNA methylation and histone modifications of BDNF, which may represent novel biomaker for detection of depression and monitoring severity and antidepressive effects. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Depression, one of the most prevalent psychiatric disorders, is considered to be one of the leading causes of disability. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Increasing evidence suggests that chronic stress is one of the leading contributing factors in the development, maintenance, or exacerbation of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Currently, the precise molecular mechanisms responsible for the pathogenesis of depression remain to be not further clarified. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 However, extensive evidence has associated a variety of intracellular pathways and signal transduction cascades with the pathophysiology and treatment of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 There is also preliminary evidence that depression is the result of a combined effect of stressful factors and genetic susceptibility. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 And it has been identified that BDNF is involved in the pathogenesis of a wide range of psychiatric disorders, including depression, schizophrenia, and anxiety disorder. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Anxiety Depression Mechanism
29636708 Notably, data from clinical investigations and laboratory animals have provided compelling evidence that BDNF is involved in the pathogenesis of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Recent evidence has identified that epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, are considered to be able to reliably differentiate the stable and heritable characteristics of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 During our previous studies, we have been focusing on investigating the clinical effects and mechanisms of acupuncture on depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Accordingly, here we established the depression rat model imitated by social isolation and chronic unpredicted mild stress (CUMS) procedures and investigated the epigenetic mechanisms underlying the antidepressant effect of acupuncture by regulating the methylation level of the analyzed region inside of BDNF promoter I and BDNF expression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 We aimed to elucidate the epigenetic mechanisms underlying the antidepressant effect of acupuncture and investigated the potential of DNA methylation and histone modifications of BDNF in monitoring severity of symptoms and antidepressant effect of acupuncture, which might shed new light on conceptual frameworks of prospects for new therapies in the treatment of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The rat model of depression was simulated by CUMS as described previously. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Differences showing the effects of stress/antidepressant treatments on depressive-like behaviors in depression rats induced by chronic unpredicted mild stress. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Differences showing the effects of stress/antidepressant treatments on the expression of DNA methylation and histone modifications levels of BDNF in depression rats induced by chronic unpredicted mild stress. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The precise mechanisms that the DNA methylation level of BDNF promoter I are involved in the pathogenesis of depression remains to be further clarified (Figure 4D). Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The rat model of depression in our study was induced by CUMS procedures, which has been evidenced to be parallel to the symptoms of depression and accurately recapitulate the human condition. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 This study aimed to elucidate the epigenetic mechanisms underlying the antidepressant effect of acupuncture and investigated the potential of DNA methylation and histone modifications of BDNF in monitoring severity of symptoms and antidepressant effect of acupuncture, which might shed new light on conceptual frameworks of prospects for new therapies in the treatment of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The result of the present study is consistent with the current study illustrated that CUMS procedures could induce depressive-like behaviors, well imitating the symptom of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 BW or body mass index (BMI) has been considered of the significant indexes in investigating the depression-like behaviors and the pathogenesis of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The precise mechanism and depressive-like behaviors of depression remain to be further verified by detailed evidence in our study. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Interestingly, significant differences was found in ameliorating ahedonia (the core symptom of depression) and mood between fluoxetine and acupuncture, suggesting the comprehensively antidepressant response of acupuncture. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mood Mechanism
29636708 in 1957 to simulate the exogenous factors for the onset of depression, including reduced sensitivity to reward, lack of pleasure, and behavioral and spiritual malaise. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The OFT can be used to verify the degree of horizontal activity of the rat, a reduction in which is a clinical sign associated with human depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Data from our previous clinical practice and experimental investigation have investigated the antidepressant effect of acupuncture, which is in consistent with studies that identified the safety and effectiveness of acupuncture therapy in treating MDD and post-stroke depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 This consistent effect of acupuncture on stress-induced depression in this study could possibly be ascribed to the function of the acupoint module since Baihui (GV 20) and Yintang (GV 29) are affiliated to the governor meridian and associated with the brain through channels and collaterals. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Notably, our previous studies have provided evidence that acupuncture at Baihui (GV 20) and Yintang (GV 29) could well alleviate depression by increasing the expression of excitatory neurotransmitter in the hippocampus, attenuating impaired neurogenesis, and inhibiting the apoptosis of hippocampal neurons. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Accordingly, acupuncture therapy could be considered an alternative option for the treatment of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 DNA Methylation and Histone Modification of BDNF in Depression Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Subsequent findings from this study identified that the stress-induced decrease in serum and hippocampal BDNF protein and BDNF mRNA were in parallel, indicating its important role in the pathogenesis of depression and the synchronous expression level of central and peripheral BDNF alterations (Figure 4G). Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Through analyzing the expression levels of BDNF mRNA, acH3K9 and HDAC2, and the DNA methylation level of BDNF promoter I at relative CpG sites in hippocampus, we identified that DNA methylation and histone modifications of BDNF in the hippocampus were involved in the pathological process of depression (Figures 4H,I). Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 In the decades that have passed, since the correlation between BDNF levels and the development of depression were identified, there has been considerable progress in understanding the roles of BDNF and its contributions to the pathogenesis of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, are considered to be very important for BDNF expression regulation and involved in the pathogenesis of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 We found that the CUMS procedures elevated the expression level of HDAC2 and induced the downregulation of acH3K9 protein and BDNF mRNA, which might contribute to the development of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Recent evidence has identified the methylation level of relative CpG islands associated with promoter I of BDNF in depression, in which the changes of DNA methylation of BDNF were postulated as a biomarker of major depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 The Role of DNA Methylation of BDNF in Depression Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Epigenetic alterations as DNA methylation, histone modifications, and non-coding RNAs are considered to be strongly associated with pathogenesis of depression with a large number of studies having examined the association between the BDNF methylation level and certain psychological diagnoses. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 It has been shown that there is an association of BDNF DNA methylation and reduced WM integrity in the anterior corona radiata in major depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 It has been demonstrated that the promoter I region is differently methylated in major depression and BDs patients. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 These partly overlap with the region differently methylated in various neuropsychiatric disorders, including depression, anxiety disorder, and schizophrenia. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Anxiety Depression Mechanism
29636708 Further research is needed to clarify the precise mechanisms whether the DNA methylation level of BDNF promoter I, promoter II, and promoter IV is involved in the pathogenesis of depression by applying bisulfite sequencing in our future study. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
29636708 Strengths of this study might shed new light on conceptual frameworks of prospects for new therapies in the treatment of depression. Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. Depression Mechanism
34108361 It is well accepted that acupuncture as a bright pearl of Chinese traditional medicine plays a significant role in the treatment of multifarious diseases, including stroke, chronic pain and even depression. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Depression Mechanism
34108361 Due to the continuously deepening research on miRNA function, MicroRNA is found to be related to a variety of physiological and pathophysiological processes, such as focal cerebral ischemia, comorbid pain and depression. Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. Depression Mechanism
25887143 Some study showed that the expression of estrogen receptor (ER) and androgen receptor (AR) increased in the CRH neurons of PVN in depression patients. BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. Depression Mechanism
25887143 Depression model was established by 21 days of UCMS combined with isolation. BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. Depression Mechanism
29946236 Electro-Acupuncture Alleviates Chronic Unpredictable Stress-Induced Depressive- and Anxiety-Like Behavior and Hippocampal Neuroinflammation in Rat Model of Depression Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Anxiety Depression Mechanism
29946236 Depression is the second leading cause of disability worldwide. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 The effects of clinical depression may be mediated by neuroinflammation such as activation of microglia and high levels of proinflammatory cytokines in certain brain areas. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 However, EA has not been rigorously studied in treatment of depression. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Depression is a prevalent mental health condition that affects more than 300 million people worldwide1, and has become the leading cause of ill health and disability across the world1. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Depression is the most common psychiatric disorder with a high mortality and morbidity rate2. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Nowadays, all available antidepressants whose action is based on the monoamine hypothesis of depression have many side effects and limited efficacies, which limits their usages and results in poor compliance. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Side Effects Depression Mechanism
29946236 EA has been used successfully to treat depression in China and several other countries worldwide for its efficiency and minimal adverse effects (Ulett et al.,; Kim et al.,; Guo et al.,; Schroeder et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Adverse Reactions Depression Mechanism
29946236 Previous clinical and preclinical studies have showed that EA relieved depressive-like behavior in patients with depression and animal models (Ulett et al.,; Duan et al.,; Li et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Moreover, our previous articles have confirmed that EA can improve hippocampal neurogenesis and atrophy of astrocytes in animal models of depression (Liu et al.,; Yang et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Furthermore, in LPS or chronic stress-induced rodent models of depression, rodents displayed depressive-like behavior and activation of NLRP3 inflammasome in some brain areas such as the hippocampus (Lu et al.,; Zhang et al.,), which were decreased after standard antidepressant medications (Pan et al.,; Du et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Two recent studies have shown further evidence that antidepressant drugs can modulate central NLRP3 inflammasome activation, microglial structure and function (Pan et al.,; Du et al.,), thereby suggesting the therapeutic potential of targeting neuroinflammation to treat depression. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 CUS induced in animal models is often regarded as one of the strongest animal models of depression because of its good predictive validity (Henn and Vollmayr,), face validity and construct validity. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Proinflammatory cytokine IL-1β in some brain areas of the limbic system, such as the prefrontal cortex and hippocampus of depressive rats, was implicated in the pathophysiology of depression (Pan et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Recent research has also indicated that activation of NLRP3 inflammasome signaling, a pivotal mediator of IL-1β function (Haneklaus et al.,), contributes to depression (Iwata et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 However, the research focus on microglia in depression presented contradictory results (Yirmiya et al.,; Santos et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 Increasing evidence has unmasked the controversy that numerical alterations of astrocytes in the front limbic systems are tightly connected with depression, as implied in post-mortem studies of patients with MDD (Wang et al.,). Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
29946236 The present results provide insight into the role of astrocytic atrophy in depression and the antidepressant effect of EA. Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. Depression Mechanism
25624811 GB20 is anatomically located on the posterior aspect of the neck, below the occipital bone, in the depression between the sternocleidomastoid muscle and the trapezius muscle. Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. Depression Mechanism
25530777 Alteration of Behavioral Changes and Hippocampus Galanin Expression in Chronic Unpredictable Mild Stress-Induced Depression Rats and Effect of Electroacupuncture Treatment Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 To explore new noninvasive treatment options for depression, this study investigated the effects of electric acupuncture (EA) for depression rat models. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Depression in rats was induced by unpredictable chronic mild stress (UCMS) combined with isolation for 21 days. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Depression is a kind of emotional disorder disease, characterized by low mood, body discomfort, and sleep disorders. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mood Mechanism
25530777 Persistent state of depression, as in clinical expression, affects patients' daily life and social function. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 World Health Organization (WHO) forecasts that depression will be the 2nd highest disease to threaten human's health and increase the economic burden by 2020. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 The number of studies about acupuncture treatment for depression has increased in recent years. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Neuropeptide is thought to be the upstream regulatory factor of monoamine neurotransmitter, which has great influence on neurotransmitter metabolism and function; its effect in the process of depression is the subject of much attention. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Animal behavioral studies and a human study suggest that Gal has a role in stress, depression like behavior, and anxiety. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Anxiety Depression Mechanism
25530777 In addition, there is an indication from previous genetic studies on humans that the Gal system is involved in psychiatric disorders including alcoholism/addiction, panic disorder, and chronic pain-associated depression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Furthermore, recent functional studies provided the first evidence that polymorphisms in a highly conserved genetic region upstream from the Gal gene regulates Gal expression in brain areas, such as the amygdala and hypothalamus, implicated in the pathogenesis of depression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 So, we think that Gal has a close relationship with depression, but there has been limited research on the effect of EA intervention to depression and its influence on Gal expression and its mechanism are not known at present. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Unpredictable chronic mild stress (UCMS) as a kind of effective depression model has been widely used in basic research and treatment selection of depression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 So this paper is aiming to use UCMS with isolation to establish depression model and use EA as intervention to treat depression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Detecting Gal mRNA and protein expression through real-time PCR and ELISA to explore the role of Gal in mechanism of rats' experimental depression and the effect of EA on them, the purpose is to provide new method and laboratory evidence for diagnosis and prevention of depression in clinic. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Depression model was established by 21 days of UCMS combined with isolation. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 The sucrose consumption test is often used to measure depression-like behavior in rats by the evaluation of the hedonic state or the ability to gain pleasure. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 The present study aims to use UCMS with isolation to establish depression model. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 This model, which has features of stress factor changeable and unpredictable, is closely related to the mechanism of occurrence and development of depression in human. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 After 21 days of induction, in model group, rats' body weight increased slowly, rewarding action weakened, and locomotor activities and explore interests reduced; while EA group could reverse this change, it indicated that the established depression model was reliable, and EA had positive effect to depression; we could come to the next step to analyze the mechanism. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 The Gal had been studied for its role in stress and depression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Many animal experimental research showed that increasing Gal signal transduction had the effect of antidepression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 For example, preclinical studies had suggested that depression was associated with aberrant Gal expression, chronic stress exposure caused the reduction in Gal in the hippocampus of rat, and giving antidepressive therapy could increase them. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Holmes has also shown that exercise exerts antidepressant effects in chronic models of depression, and chronic antidepressant treatment elevates Gal mRNA in the locus coeruleus (LC) similarly to exercise. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 For example, it had been reported that Flinders sensitive line depression model induced an increase in Gal expression in dorsal raphe nucleus (DRN) and UCMS induced an increase in Gal gene expression in amygdale and LC. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Shan and Gao's research showed that the content of Gal in experimental depression rats' hippocampus increased, but giving Gal and its receptor agonist could enhance rats' ability of independent activities and raise learning capacity. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 EA treatment could improve rats' behavior of depression model and increase the expression of Gal; it indicated that the increase of Gal content was a kind of protective regulation to depression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism
25530777 Therefore, we speculated that the reason which EA treatment could increase the expression of Gal might be that EA could activate GalR2 in the dorsal area of hippocampus to protect and promote the formation of cognitive function then to antidepression. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Cognitive Function Depression Mechanism
25530777 This pilot EA study on depression has a small sample size. Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. Depression Mechanism