- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Lower Incidence of Side Effects
- Toxic Side Effects
- Acupuncture anesthesia can help reduce the toxic side effects of certain medications used in surgery, minimizing harm to the patient's body.
- Hypothermia
- Acupuncture anesthesia can aid in maintaining normal body temperature during surgery, reducing the risk of hypothermia.
- Stress Response
- Acupuncture anesthesia can mitigate the body's stress response to surgery, promoting a more relaxed and stable physiological state.
- Nausea and Vomiting
- Acupuncture anesthesia has antiemetic properties, effectively preventing postoperative nausea and vomiting.
- Adverse Reactions
- Acupuncture anesthesia can minimize adverse reactions to anesthesia drugs, enhancing patient safety during surgical procedures.
- Side Effects
- Acupuncture anesthesia's minimal side effects make it a safer alternative to traditional anesthesia methods.
- Insomnia
- Acupuncture anesthesia can improve sleep quality by reducing postoperative pain and discomfort.
- Urinary Retention
- Acupuncture anesthesia can help prevent urinary retention, ensuring proper urinary function post-surgery.
- Sleep Quality
- Acupuncture anesthesia contributes to better sleep quality by alleviating pain and promoting relaxation.
- Urinary Incontinence
- Acupuncture anesthesia can address urinary incontinence issues, improving bladder control post-surgery.
Acupuncture anesthesia for Lower Incidence of Side Effects-Insomnia
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 12391715 | The use of valerian, melatonin, chamomile, passionflower, exercise, acupuncture, and behavioral therapies (i.e., sleep restriction, stimulus control, relaxation, and sleep hygiene) for insomnia is discussed. | Prim Care. 2002 Jun;29(2):339-60, vii. doi: 10.1016/s0095-4543(01)00003-3. | Insomnia | Review |
| 12418362 | There is sufficient evidence, for example, to support the use of a) acupuncture for addiction problems and chronic musculoskeletal pain, b) hypnosis for cancer pain and nausea, c) massage therapy for anxiety, and the use of d) mind-body techniques such as meditation, relaxation, and biofeedback for pain, insomnia, and anxiety. | Psychiatr Q. 2002 Winter;73(4):367-81. doi: 10.1023/a:1020472218839. | Cancer Pain Insomnia Nausea and Vomiting Anxiety | Review |
| 14651709 | Effects of acupuncture therapy on insomnia. | J Adv Nurs. 2003 Nov;44(4):375-84. doi: 10.1046/j.0309-2402.2003.02816.x. | Insomnia | Review |
| 14651709 | BACKGROUND: Acupuncture therapy, commonly used in clinical practice in oriental cultures, has the potential to produce a positive effect with patients experiencing insomnia. | J Adv Nurs. 2003 Nov;44(4):375-84. doi: 10.1046/j.0309-2402.2003.02816.x. | Insomnia | Review |
| 14651709 | AIM: The purposes of this systematic review were: (1) to assess the trends across intervention studies using acupuncture for insomnia from 1975 to 2002, (2) to examine dependent variables, and (3) to evaluate the effects of acupuncture therapy on insomnia in older people. | J Adv Nurs. 2003 Nov;44(4):375-84. doi: 10.1046/j.0309-2402.2003.02816.x. | Insomnia | Review |
| 14651709 | A wide range of electronic databases was searched using the keywords 'insomnia', 'acupuncture' and 'experimental design'. | J Adv Nurs. 2003 Nov;44(4):375-84. doi: 10.1046/j.0309-2402.2003.02816.x. | Insomnia | Review |
| 14651709 | Papers were included if they were published in the English language between 1975 and 2002 and described an experimental study using acupuncture therapy to treat insomnia. | J Adv Nurs. 2003 Nov;44(4):375-84. doi: 10.1046/j.0309-2402.2003.02816.x. | Insomnia | Review |
| 14651709 | CONCLUSION: The results of this review suggest that acupuncture may be an effective intervention for the relief of insomnia. | J Adv Nurs. 2003 Nov;44(4):375-84. doi: 10.1046/j.0309-2402.2003.02816.x. | Insomnia | Review |
| 14651709 | More work is also needed to promote the long-term therapeutic effects of acupuncture and to compare it with other therapies for insomnia. | J Adv Nurs. 2003 Nov;44(4):375-84. doi: 10.1046/j.0309-2402.2003.02816.x. | Insomnia | Review |
| 16092807 | Other preliminary data also suggests acupuncture might be effective for chemotherapy-induced leukopenia, postchemotherapy fatigue, radiation therapy-induced xerostomia, insomnia, and anxiety. | Semin Oncol Nurs. 2005 Aug;21(3):190-5. doi: 10.1016/j.soncn.2005.04.008. | Insomnia Anxiety | Review |
| 16414335 | Overall, controlled studies of acupuncture did not reliably improve hot flashes, sleep disturbances, or mood when compared with nonspecific acupuncture, estrogen therapy, or superficial needling. | Am J Med. 2005 Dec 19;118 Suppl 12B:109-17. doi: 10.1016/j.amjmed.2005.09.058. | Insomnia Mood | Review |
| 17631261 | Role of acupuncture in the treatment of insomnia: a comprehensive review. | Complement Ther Clin Pract. 2007 Aug;13(3):184-93. doi: 10.1016/j.ctcp.2007.01.001. Epub 2007 Apr 6. | Insomnia | Review |
| 17631261 | More and more Americans are seeking complementary/alternative treatments for many conditions including insomnia and there are anecdotal reports/case series of use of acupuncture in treating insomnia. | Complement Ther Clin Pract. 2007 Aug;13(3):184-93. doi: 10.1016/j.ctcp.2007.01.001. Epub 2007 Apr 6. | Insomnia | Review |
| 17631261 | To examine critically the role of acupuncture in treatment of insomnia, we performed a systematic review of published literature. | Complement Ther Clin Pract. 2007 Aug;13(3):184-93. doi: 10.1016/j.ctcp.2007.01.001. Epub 2007 Apr 6. | Insomnia | Review |
| 17631261 | Despite the limitations of the reviewed studies, all of them consistently indicate significant improvement in insomnia with acupuncture. | Complement Ther Clin Pract. 2007 Aug;13(3):184-93. doi: 10.1016/j.ctcp.2007.01.001. Epub 2007 Apr 6. | Insomnia | Review |
| 17631261 | Further methodologically strong, randomized controlled studies with large sample size are needed to assess the usefulness of acupuncture in treatment of insomnia and explore the possible mechanisms underlying the effects of acupuncture on sleep and sleep disorders. | Complement Ther Clin Pract. 2007 Aug;13(3):184-93. doi: 10.1016/j.ctcp.2007.01.001. Epub 2007 Apr 6. | Insomnia | Review |
| 17636800 | Acupuncture for insomnia. | Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005472. doi: 10.1002/14651858.CD005472.pub2. | Insomnia | Review |
| 17636800 | BACKGROUND: Although conventional non-pharmacological and pharmacological treatments for insomnia are effective in many people, alternative therapies such as acupuncture are still widely practiced. | Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005472. doi: 10.1002/14651858.CD005472.pub2. | Insomnia | Review |
| 17636800 | OBJECTIVES: To determine the efficacy and safety of acupuncture in people with insomnia. | Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005472. doi: 10.1002/14651858.CD005472.pub2. | Insomnia | Review |
| 17636800 | SELECTION CRITERIA: Randomised controlled trials evaluating any form of acupuncture involving participants of any age with any type of insomnia were included. | Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005472. doi: 10.1002/14651858.CD005472.pub2. | Insomnia | Review |
| 17636800 | The combined result from three studies reporting subjective insomnia improvement showed that acupuncture or its variants was not more significantly effective than control (RR = 1.66, 95% CI = 0.68 to -4.03) and significant statistical heterogeneity was observed. | Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005472. doi: 10.1002/14651858.CD005472.pub2. | Insomnia | Review |
| 17636800 | AUTHORS' CONCLUSIONS: The small number of randomised controlled trials, together with the poor methodological quality and significant clinical heterogeneity, means that the current evidence is not sufficiently extensive or rigorous to support the use of any form of acupuncture for the treatment of insomnia. | Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005472. doi: 10.1002/14651858.CD005472.pub2. | Insomnia | Review |
| 17636800 | Larger high quality clinical trials employing appropriate randomisation concealment and blinding with longer follow-up are needed to further investigate the efficacy and safety of acupuncture for the treatment of insomnia. | Cochrane Database Syst Rev. 2007 Jul 18;(3):CD005472. doi: 10.1002/14651858.CD005472.pub2. | Insomnia | Review |
| 17718650 | Auricular acupuncture treatment for insomnia: a systematic review. | J Altern Complement Med. 2007 Jul-Aug;13(6):669-76. doi: 10.1089/acm.2006.6400. | Insomnia | Review |
| 17718650 | OBJECTIVES: To review trials on the efficacy and safety of auricular acupuncture (AA) treatment for insomnia and to identify the most commonly used auricular acupoints for treating insomnia in the studies via a frequency analysis. | J Altern Complement Med. 2007 Jul-Aug;13(6):669-76. doi: 10.1089/acm.2006.6400. | Insomnia | Review |
| 18160929 | Our suggestion is supported by experimental and clinical studies showing that acupuncture may affect insomnia and alertness, and that there may be neurophysiologic bases for these specific effects. | Acupunct Med. 2007 Dec;25(4):184-97. doi: 10.1136/aim.25.4.184. | Insomnia | Review |
| 18754807 | Auricular acupuncture for insomnia: a systematic review. | Int J Clin Pract. 2008 Nov;62(11):1744-52. doi: 10.1111/j.1742-1241.2008.01876.x. Epub 2008 Aug 27. | Insomnia | Review |
| 20334470 | METHODS AND PROCEDURES: Subjects participating in one of two externally funded studies addressing the role of acupuncture in treating insomnia in TBI underwent actigraphy for the purpose of quantifying sleep time. | Brain Inj. 2010;24(5):748-54. doi: 10.3109/02699051003692167. | Insomnia | Review |
| 20605536 | A potential role for acupuncture was found in the following cancer symptoms: pain, nausea and vomiting, xerostomia, hot flushes, fatigue, anxiety, depression and insomnia. | Auton Neurosci. 2010 Oct 28;157(1-2):96-100. doi: 10.1016/j.autneu.2010.05.001. | Insomnia Nausea and Vomiting Anxiety Depression | Review |
| 20626151 | Evaluation on acupuncture treatment of primary insomnia. | Zhen Ci Yan Jiu. 2010 Apr;35(2):151-5. | Insomnia | Review |
| 20626151 | Acupuncture treatment of insomnia has been reported for many years, but its validity remains controversial up to now. | Zhen Ci Yan Jiu. 2010 Apr;35(2):151-5. | Insomnia | Review |
| 20626151 | In the present review, the authors took ""Acupuncture"", ""Insomnia"" as the key words to do a literature search from databases in both Chinese and English via computer retrieval system and also conducted a hand-made retrieval from journals of Chinese medicine as Chinese Acu-moxibustion, and collections of theses of the related academic conferences. | Zhen Ci Yan Jiu. 2010 Apr;35(2):151-5. | Insomnia | Review |
| 20626151 | In conclusion, there have had no high-quality clinical trails about acupuncture treatment of primary insomnia in China at the present, and the related evaluating methods could not definitely confirm the efficacy of acupuncture in relieving insomnia. | Zhen Ci Yan Jiu. 2010 Apr;35(2):151-5. | Insomnia | Review |
| 20626151 | Therefore, a strict and scientific clinical trail scheme being in line with evidence-based medicine is urgently needed in the coming studies on acupuncture treatment of primary insomnia. | Zhen Ci Yan Jiu. 2010 Apr;35(2):151-5. | Insomnia | Review |
| 20965131 | While systematic reviews have been conducted on acupuncture and valerian in the treatment of insomnia, to date no comprehensive review has been conducted on all major CAM treatments. | Sleep Med Rev. 2011 Apr;15(2):99-106. doi: 10.1016/j.smrv.2010.04.001. Epub 2010 Jun 8. | Insomnia | Review |
| 20965131 | Among the studies that met inclusion criteria, there was evidentiary support in the treatment of chronic insomnia for acupressure (d=1.42-2.12), tai chi (d=0.22-2.15), yoga (d=0.66-1.20), mixed evidence for acupuncture and L-tryptophan, and weak and unsupportive evidence for herbal medicines such as valerian. | Sleep Med Rev. 2011 Apr;15(2):99-106. doi: 10.1016/j.smrv.2010.04.001. Epub 2010 Jun 8. | Insomnia | Review |
| 21463162 | Acupuncture for insomnia? An overview of systematic reviews. | Eur J Gen Pract. 2011 Jun;17(2):116-23. doi: 10.3109/13814788.2011.568475. Epub 2011 Apr 4. | Insomnia | Review |
| 21463162 | BACKGROUND: Several systematic reviews of acupuncture as a treatment of insomnia have recently emerged. | Eur J Gen Pract. 2011 Jun;17(2):116-23. doi: 10.3109/13814788.2011.568475. Epub 2011 Apr 4. | Insomnia | Review |
| 21463162 | AIM: To summarize and critically evaluate these reviews with a view of defining the reasons for their discrepant conclusions and providing an overall verdict about the therapeutic value of acupuncture for insomnia. | Eur J Gen Pract. 2011 Jun;17(2):116-23. doi: 10.3109/13814788.2011.568475. Epub 2011 Apr 4. | Insomnia | Review |
| 21463162 | RESULTS: Ten systematic reviews of acupuncture for insomnia were published between 2003 and 2010. | Eur J Gen Pract. 2011 Jun;17(2):116-23. doi: 10.3109/13814788.2011.568475. Epub 2011 Apr 4. | Insomnia | Review |
| 21463162 | CONCLUSION: The evidence for acupuncture as a treatment of insomnia is plagued by important limitations, e.g. | Eur J Gen Pract. 2011 Jun;17(2):116-23. doi: 10.3109/13814788.2011.568475. Epub 2011 Apr 4. | Insomnia | Review |
| 22419418 | Acupuncture may also cause sedative and hypnotic effects in cancer patients for treating nervousness and insomnia. | Am J Chin Med. 2012;40(2):219-29. doi: 10.1142/S0192415X12500176. | Insomnia | Review |
| 22841034 | Previous randomized controlled trials (RCTs) have shown that acupuncture may be efficacious for insomnia. | Sleep Med. 2012 Sep;13(8):971-84. doi: 10.1016/j.sleep.2012.06.003. Epub 2012 Jul 25. | Insomnia | Review |
| 22972087 | Acupuncture for insomnia. | Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005472. doi: 10.1002/14651858.CD005472.pub3. | Insomnia | Review |
| 22972087 | BACKGROUND: Although conventional non-pharmacological and pharmacological treatments for insomnia are effective in many people, alternative therapies such as acupuncture are widely practised. | Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005472. doi: 10.1002/14651858.CD005472.pub3. | Insomnia | Review |
| 22972087 | However, it remains unclear whether current evidence is rigorous enough to support acupuncture for the treatment of insomnia. | Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005472. doi: 10.1002/14651858.CD005472.pub3. | Insomnia | Review |
| 22972087 | OBJECTIVES: To determine the efficacy and safety of acupuncture for insomnia. | Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005472. doi: 10.1002/14651858.CD005472.pub3. | Insomnia | Review |
| 22972087 | SELECTION CRITERIA: Randomised controlled trials evaluating any form of acupuncture for insomnia. | Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005472. doi: 10.1002/14651858.CD005472.pub3. | Insomnia | Review |
| 22972087 | AUTHORS' CONCLUSIONS: Due to poor methodological quality, high levels of heterogeneity and publication bias, the current evidence is not sufficiently rigorous to support or refute acupuncture for treating insomnia. | Cochrane Database Syst Rev. 2012 Sep 12;(9):CD005472. doi: 10.1002/14651858.CD005472.pub3. | Insomnia | Review |
| 22997800 | OBJECTIVE: Treatment of insomnia with acupuncture is taken as an example to explore the significance and problems existed in the present systematic evaluation in establishment of guidance for clinical practice. | Zhongguo Zhen Jiu. 2012 Jul;32(7):649-52. | Insomnia | Review |
| 24215924 | Acupuncture has traditionally been used for problems including anxiety, insomnia, stress, and depression in China and other East Asian countries. | Int Rev Neurobiol. 2013;111:197-216. doi: 10.1016/B978-0-12-411545-3.00010-9. | Insomnia Anxiety Depression | Review |
| 24215925 | Acupuncture for the treatment of insomnia. | Int Rev Neurobiol. 2013;111:217-34. doi: 10.1016/B978-0-12-411545-3.00011-0. | Insomnia | Review |
| 24215925 | Acupuncture is traditionally used for the treatment of insomnia in China and now is widely accepted in the Western countries. | Int Rev Neurobiol. 2013;111:217-34. doi: 10.1016/B978-0-12-411545-3.00011-0. | Insomnia | Review |
| 24215925 | Many research works on clinical applications of acupuncture in the treatment of insomnia and the potential mechanisms underlying the acupuncture treatment have been reported. | Int Rev Neurobiol. 2013;111:217-34. doi: 10.1016/B978-0-12-411545-3.00011-0. | Insomnia | Review |
| 24215925 | A number of clinical studies, mainly randomized controlled clinical trials, have shown positive effects in acupuncture treatment of insomnia. | Int Rev Neurobiol. 2013;111:217-34. doi: 10.1016/B978-0-12-411545-3.00011-0. | Insomnia | Review |
| 24215925 | Some of the studies demonstrated that acupuncture treatment appeared to be better than conventional pharmacological drugs in the improvement of insomnia. | Int Rev Neurobiol. 2013;111:217-34. doi: 10.1016/B978-0-12-411545-3.00011-0. | Insomnia | Review |
| 24215925 | Evidence has suggested that the clinical efficacy of acupuncture in treatment of insomnia is potentially mediated by a variety of neurotransmitters including norepinephrine, melatonin, gamma-aminobutyric acid, and beta-endorphin. | Int Rev Neurobiol. 2013;111:217-34. doi: 10.1016/B978-0-12-411545-3.00011-0. | Insomnia | Review |
| 24501113 | Acupuncture is being adopted by cancer patients for a wide range of cancer-related symptoms including highly prevalent psychological symptoms like depression, anxiety, insomnia, and impairment in quality of life. | Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. | Insomnia Anxiety Depression | Review |
| 24501113 | All published studies that met our review criteria demonstrate a positive signal for acupuncture for the treatment of depression, anxiety, sleep disturbance, and for improving quality of life with most results showing statistical significance. | Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. | Insomnia Anxiety Depression | Review |
| 24501113 | However, there are only a handful of acupuncture studies that were specifically designed to evaluate depression, sleep disturbance, and quality of life as primary outcomes, and no studies were found that looked at anxiety as a primary outcome in this population. | Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. | Insomnia Anxiety Depression | Review |
| 24501113 | In conclusion, results are encouraging for the development of randomized trials to directly evaluate the therapeutic impact of acupuncture in cancer-related psychological symptoms, including depression, anxiety, sleep disturbance, and quality of life, but attention to acupuncture methodological specific challenges in the development of high-quality research is necessary. | Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. | Insomnia Anxiety Depression | Review |
| 25233674 | Auricular acupuncture for primary insomnia: a systematic review based on GRADE system. | Zhongguo Zhen Jiu. 2014 Jul;34(7):726-30. | Insomnia | Review |
| 25233674 | The clinical efficacy and safety of auricular acupuncture (AA) for treatment of primary insomnia was evaluated. | Zhongguo Zhen Jiu. 2014 Jul;34(7):726-30. | Insomnia | Review |
| 25349958 | Acupuncture may not be suggested, and cognitive-behavioral therapy that is not tailored for insomnia probably should not be considered. | Menopause. 2015 Jun;22(6):674-84. doi: 10.1097/GME.0000000000000348. | Insomnia | Review |
| 26880252 | The meta-analysis also demonstrated that acupuncture produced small-to-large effects on adverse symptoms including pain, fatigue, sleep disturbance, and some gastrointestinal discomfort; however, no significant effect was found on the frequency of hot flashes (Cohen's d = -0.02; 95% CI = -1.49 to 1.45; P = 0.97; I(2) = 36%) and mood distress (P > 0.05). | J Pain Symptom Manage. 2016 Apr;51(4):728-747. doi: 10.1016/j.jpainsymman.2015.11.027. Epub 2016 Feb 12. | Adverse Reactions Insomnia Mood | Review |
| 27181124 | Hazards of insomnia and the effects of acupuncture treatment on insomnia. | J Integr Med. 2016 May;14(3):174-86. doi: 10.1016/S2095-4964(16)60248-0. | Insomnia | Review |
| 27181124 | Fortunately, acupuncture can ease the symptoms of insomnia. | J Integr Med. 2016 May;14(3):174-86. doi: 10.1016/S2095-4964(16)60248-0. | Insomnia | Review |
| 27181124 | This review summarizes the hazards associated with insomnia and the use of acupuncture in its treatment. | J Integr Med. 2016 May;14(3):174-86. doi: 10.1016/S2095-4964(16)60248-0. | Insomnia | Review |
| 27181124 | Furthermore, the authors introduce an effective and low-cost method of treating insomnia with acupuncture. | J Integr Med. 2016 May;14(3):174-86. doi: 10.1016/S2095-4964(16)60248-0. | Insomnia | Review |
| 27181124 | Acupuncture, which has showed effectiveness against insomnia and its complications, may be an effective and complementary method for the treatment of insomnia and associated maladies. | J Integr Med. 2016 May;14(3):174-86. doi: 10.1016/S2095-4964(16)60248-0. | Insomnia | Review |
| 27261976 | A systematic review of acupuncture for sleep quality in people with insomnia. | Complement Ther Med. 2016 Jun;26:11-20. doi: 10.1016/j.ctim.2016.02.007. Epub 2016 Feb 18. | Insomnia Sleep Quality | Review |
| 27261976 | We performed a systematic review and meta-analysis to examine the effects of acupuncture for insomnia. | Complement Ther Med. 2016 Jun;26:11-20. doi: 10.1016/j.ctim.2016.02.007. Epub 2016 Feb 18. | Insomnia | Review |
| 27261976 | Acupuncture point combinations included the use of at least one of the recommended points for insomnia, HT7, GV20, SP6. | Complement Ther Med. 2016 Jun;26:11-20. doi: 10.1016/j.ctim.2016.02.007. Epub 2016 Feb 18. | Insomnia | Review |
| 27526331 | Finally, some of the evidence in association with mechanisms of action of acupuncture in insomnia, in particular its impact on cardiovascular variables associated with insomnia, is presented, along with findings of systematic reviews. | J Altern Complement Med. 2016 Sep;22(9):684-94. doi: 10.1089/acm.2016.0044. Epub 2016 Aug 15. | Cardiovascular Insomnia | Review |
| 27578355 | Insomnia: can acupuncture help? | Pain Manag. 2017 Jan;7(1):49-57. doi: 10.2217/pmt-2016-0025. Epub 2016 Aug 31. | Insomnia | Review |
| 27578355 | Acupuncture is observed clinically to improve sleeping in chronic pain patients, but reviews are unable firmly to recommend acupuncture for insomnia as many trials are methodologically inadequate, despite most being acupuncture positive. | Pain Manag. 2017 Jan;7(1):49-57. doi: 10.2217/pmt-2016-0025. Epub 2016 Aug 31. | Insomnia | Review |
| 27578355 | So, as the safety profile of acupuncture is excellent, it seems reasonable to utilize acupuncture in a nonpharmacological approach to combating insomnia, despite lack of formal evidence. | Pain Manag. 2017 Jan;7(1):49-57. doi: 10.2217/pmt-2016-0025. Epub 2016 Aug 31. | Insomnia | Review |
| 27696279 | Patients may seek complementary and alternative medicine (CAM), which may include acupuncture and herbal formulations, not only to manage nausea and vomiting, but also to remedy those symptoms associated with chronic illness, like insomnia and general fatigue. | Curr Treat Options Gastroenterol. 2016 Dec;14(4):401-409. doi: 10.1007/s11938-016-0104-0. | Insomnia Nausea and Vomiting | Review |
| 28525221 | The management of insomnia can be non-drug treatment (exercise, light therapy, acupuncture and self-treatment cognitive behavioral therapy) but also drug treatment (benzodiazepine, Z-DRUGS, melatonin, antidepressants, herbal medicines, neuroleptics and antihistaminics). | Rev Med Brux. 2016;37(4):235-241. | Insomnia | Review |
| 28802468 | This article discusses the evidence supporting integrative approaches to insomnia treatment, including cognitive-behavioral therapy and mind-body therapies (mindfulness meditation, yoga, tai chi), as well as emerging data for use of other less well supported approaches (dietary supplements, acupuncture). | Med Clin North Am. 2017 Sep;101(5):865-879. doi: 10.1016/j.mcna.2017.04.005. Epub 2017 Jun 20. | Insomnia | Review |
| 29797908 | Governor vessel daoqi method of acupuncture"" combined with estazolam for insomnia: a randomized controlled trial. | Zhongguo Zhen Jiu. 2018 May 12;38(5):4633-7. doi: 10.13703/j.0255-2930.2018.05.003. | Insomnia | Review |
| 29797908 | OBJECTIVE: To compare the clinical efficacy differences between ""governor vessel daoqi method of acupuncture"" combined with estazolam and estazolam alone for insomnia. | Zhongguo Zhen Jiu. 2018 May 12;38(5):4633-7. doi: 10.13703/j.0255-2930.2018.05.003. | Insomnia | Review |
| 29797908 | CONCLUSION: ""Governor vessel daoqi method of acupuncture"" combined with estazolam could significantly improve insomnia, which are superior to estazolam alone. | Zhongguo Zhen Jiu. 2018 May 12;38(5):4633-7. doi: 10.13703/j.0255-2930.2018.05.003. | Insomnia | Review |
| 29797920 | METHODS: With ""moxibustion"" ""acupuncture-moxibustion"" ""Yongquan (KI 1)"" ""insomnia"" and ""sleep disorder"", etc. | Zhongguo Zhen Jiu. 2018 May 12;38(5):5413-4. doi: 10.13703/j.0255-2930.2018.05.024. | Insomnia | Review |
| 29797920 | Few papers selected moxibustion at Yongquan (KI 1) as independent treatment for insomnia; most papers combined moxibustion with acupuncture, massage, etc. | Zhongguo Zhen Jiu. 2018 May 12;38(5):5413-4. doi: 10.13703/j.0255-2930.2018.05.024. | Insomnia | Review |
| 30286626 | In patients with CKD, acupuncture improves renal function, reduces proteinuria, controls hypertension, corrects anemia, relieves pain, and controls many hemodialysis-related complications such as uremic pruritus, insomnia and fatigue. | Am J Chin Med. 2018;46(6):1169-1185. doi: 10.1142/S0192415X18500611. | Insomnia Kidney | Review |
| 30670275 | Acupuncture for treatment of insomnia: An overview of systematic reviews. | Complement Ther Med. 2019 Feb;42:407-416. doi: 10.1016/j.ctim.2018.12.020. Epub 2018 Dec 28. | Insomnia | Review |
| 30670275 | PURPOSE: To evaluate the reliability of the methodological quality and outcome measures of systematic review (SR) /meta-analysis (MA) of acupuncture for insomnia. | Complement Ther Med. 2019 Feb;42:407-416. doi: 10.1016/j.ctim.2018.12.020. Epub 2018 Dec 28. | Insomnia | Review |
| 30670275 | CONCLUSION: Most of the reviews included suggested that the acupuncture group was more effective than the control group in the treatment of insomnia, but the methodological quality of most of the studies and the quality of evidence were low. | Complement Ther Med. 2019 Feb;42:407-416. doi: 10.1016/j.ctim.2018.12.020. Epub 2018 Dec 28. | Insomnia | Review |
| 30672210 | We found ear-acupuncture are mainly used in treating nausea and vomiting caused by radiation and chemotherapy (shenmen (TF(4)), jiaogan (AH(6a)), wei (CO(4)), pi (CO(13)), etc), insomnia in the rehabilitation period (xin (CO(15)), pizhixia (AT(4)), shenmen (TF(4)), etc), depression and anxiety (pizhixia (AT(4)), shenmen (TF(4)), pi (CO(13)), wei (CO(4)), xin (CO(15)), gan (CO(12)), etc), and joint pain (pain point), etc. | Zhongguo Zhen Jiu. 2018 Nov 12;38(11):1249-54. doi: 10.13703/j.0255-2930.2018.11.031. | Insomnia Nausea and Vomiting Anxiety Depression | Review |
| 31013432 | Acupuncture for Primary Insomnia: An Updated Systematic Review of Randomized Controlled Trials. | J Altern Complement Med. 2019 May;25(5):451-474. doi: 10.1089/acm.2018.0046. Epub 2019 Apr 23. | Insomnia | Review |
| 31013432 | Introduction: Acupuncture as one of the alternative therapies for insomnia is widely used in Asia and increasingly employed in western countries. | J Altern Complement Med. 2019 May;25(5):451-474. doi: 10.1089/acm.2018.0046. Epub 2019 Apr 23. | Insomnia | Review |
| 31013432 | Objectives: To provide updated evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture for primary insomnia. | J Altern Complement Med. 2019 May;25(5):451-474. doi: 10.1089/acm.2018.0046. Epub 2019 Apr 23. | Insomnia | Review |
| 31221943 | RESULTS: The findings support the usefulness of this method to deal with sleep disturbances through different forms of acupuncture, including traditional, sham, shock wave, venom, and Mongolian modes, as well as acupressure, either applied standalone or coupled with other therapies. | Altern Ther Health Med. 2020 Jan;26(1):26-48. | Insomnia | Review |
| 31567461 | Cognitive-behavioral therapy for insomnia, mindfulness-based therapies, qigong/tai chi, and acupuncture have the most evidence for improving sleep and insomnia, whereas yoga, acupressure, massage, and reflexology are still being investigated or building their evidence base. | Cancer J. 2019 Sep/Oct;25(5):337-342. doi: 10.1097/PPO.0000000000000398. | Insomnia | Review |
| 31725474 | RESULTS: The results of network meta-analysis for sleep efficiency showed that orexin receptor antagonists had the maximum effect size of 1.35 (95% confidence interval [CI], 0.88-1.82), followed by gamma-aminobutyric acid agonists of 1.28 (95% CI, 0.85-1.71), cognitive behavioral therapy for insomnia of 1.07 (95% CI, 0.10-2.05), acupuncture of 0.64 (95% CI, -0.17 to 2.36), and repetitive transcranial magnetic stimulation of 0.61 (95% CI, -0.52 to 1.75), respectively. | Clin Neuropharmacol. 2019 Nov/Dec;42(6):197-202. doi: 10.1097/WNF.0000000000000369. | Insomnia | Review |
| 31801099 | Studies evaluated the efficacy of various interventions: cognitive behavioral interventions for insomnia (4); pharmacotherapy (1); acupuncture (1); mindfulness and yoga (3); relaxation (5) and herbal medication (2). | Sleep Med Rev. 2020 Apr;50:101234. doi: 10.1016/j.smrv.2019.101234. Epub 2019 Nov 14. | Insomnia | Review |
| 32005059 | Placebo effect of acupuncture on insomnia: a systematic review and meta-analysis. | Ann Palliat Med. 2020 Jan;9(1):19-29. doi: 10.21037/apm.2019.11.15. | Insomnia | Review |
| 32005059 | BACKGROUND: Acupuncture is a common alternative therapy for clinical treatment of insomnia. | Ann Palliat Med. 2020 Jan;9(1):19-29. doi: 10.21037/apm.2019.11.15. | Insomnia | Review |
| 32005059 | To clarify whether acupuncture treatment of insomnia is only due to its placebo effect, a systematic review and a meta-analysis were designed based on the comparison between acupuncture and sham acupuncture. | Ann Palliat Med. 2020 Jan;9(1):19-29. doi: 10.21037/apm.2019.11.15. | Insomnia | Review |
| 32005059 | In addition, a significant difference was detected in the change of Insomnia Severity Index (ISI) scores (362 adult patients, 4 trials) between acupuncture and sham acupuncture (P<0.0001). | Ann Palliat Med. 2020 Jan;9(1):19-29. doi: 10.21037/apm.2019.11.15. | Insomnia | Review |
| 32005059 | CONCLUSIONS: Acupuncture treatment of insomnia is efficacious, not because of its placebo effect. | Ann Palliat Med. 2020 Jan;9(1):19-29. doi: 10.21037/apm.2019.11.15. | Insomnia | Review |
| 32005059 | Moreover, insomnia patients with major depression disorder were not recommended to use only acupuncture treatment. | Ann Palliat Med. 2020 Jan;9(1):19-29. doi: 10.21037/apm.2019.11.15. | Insomnia Depression | Review |
| 33186824 | The effects of acupuncture versus sham/placebo acupuncture for insomnia: A systematic review and meta-analysis of randomized controlled trials. | Complement Ther Clin Pract. 2020 Nov;41:101253. doi: 10.1016/j.ctcp.2020.101253. Epub 2020 Nov 1. | Insomnia | Review |
| 33186824 | BACKGROUND: Acupuncture has been found to be an effective treatment for insomnia. | Complement Ther Clin Pract. 2020 Nov;41:101253. doi: 10.1016/j.ctcp.2020.101253. Epub 2020 Nov 1. | Insomnia | Review |
| 33186824 | Meta-analysis results showed that acupuncture therapy was superior to sham/placebo acupuncture in terms of improving Pittsburgh sleep quality index (PSQI), insomnia severity index (ISI), total sleep time (TST), sleep-onset latency (SOL), wake after sleep onset (WASO), sleep efficiency (SE), even during the follow-up period, acupuncture therapy was superior to sham/placebo acupuncture on PSQI. | Complement Ther Clin Pract. 2020 Nov;41:101253. doi: 10.1016/j.ctcp.2020.101253. Epub 2020 Nov 1. | Insomnia Sleep Quality | Review |
| 33186824 | Conclusion: Based on the outcomes included in this study, the efficacy of acupuncture was superior to that of placebo acupuncture in treating insomnia. | Complement Ther Clin Pract. 2020 Nov;41:101253. doi: 10.1016/j.ctcp.2020.101253. Epub 2020 Nov 1. | Insomnia | Review |
| 33305982 | Psychotherapy-based approaches might be useful for sleep disturbance after TBI and acupuncture may help improve insomnia or sleep disturbance following stroke or TBI, respectively. | Disabil Rehabil. 2022 Jun;44(13):2975-2987. doi: 10.1080/09638288.2020.1856948. Epub 2020 Dec 11. | Insomnia | Review |
| 33305982 | CONCLUSIONS: Some conservative interventions might be useful for improving sleep disturbance or disorders in these populations, but further research is required.IMPLICATIONS FOR REHABILITATIONSleep disturbance is common following stroke and traumatic brain injury, with insomnia and obstructive sleep apnoea being the most frequently diagnosed sleep disorders.Psychotherapy-based approaches might be useful for sleep disturbance after TBI and acupuncture may help improve insomnia or sleep disturbance following stroke or TBI, respectively.Morning bright light therapy appeared to be more beneficial for fatigue rather than sleep disturbance after TBI, and the evidence for exercise was less clear. | Disabil Rehabil. 2022 Jun;44(13):2975-2987. doi: 10.1080/09638288.2020.1856948. Epub 2020 Dec 11. | Insomnia | Review |
| 33610071 | Can acupuncture improve objective sleep indices in patients with primary insomnia? A systematic review and meta-analysis. | Sleep Med. 2021 Apr;80:244-259. doi: 10.1016/j.sleep.2021.01.053. Epub 2021 Feb 2. | Insomnia | Review |
| 33610071 | BACKGROUND: The efficacy of acupuncture for treating primary insomnia (PI) has been explored in several meta-analyses where the outcomes measures were based on subjective self-reported sleep rating scales. | Sleep Med. 2021 Apr;80:244-259. doi: 10.1016/j.sleep.2021.01.053. Epub 2021 Feb 2. | Insomnia | Review |
| 33957493 | Acupuncture treatment for post-stroke insomnia: A systematic review and meta-analysis of randomized controlled trials. | Complement Ther Clin Pract. 2021 Aug;44:101396. doi: 10.1016/j.ctcp.2021.101396. Epub 2021 Apr 23. | Insomnia | Review |
| 33957493 | OBJECTIVES: The meta-analysis aimed to assess the effectiveness and safety of acupuncture for the treatment of post-stroke insomnia. | Complement Ther Clin Pract. 2021 Aug;44:101396. doi: 10.1016/j.ctcp.2021.101396. Epub 2021 Apr 23. | Insomnia | Review |
| 33957493 | CONCLUSION: The existing evidence suggests acupuncture may be more effective in treating post-stroke insomnia than drugs. | Complement Ther Clin Pract. 2021 Aug;44:101396. doi: 10.1016/j.ctcp.2021.101396. Epub 2021 Apr 23. | Insomnia | Review |
| 34049475 | Efficacy of Acupuncture for Insomnia: A Systematic Review and Meta-Analysis. | Am J Chin Med. 2021;49(5):1135-1150. doi: 10.1142/S0192415X21500543. Epub 2021 May 27. | Insomnia | Review |
| 34049475 | Patients with insomnia frequently use acupuncture as an alternative treatment to pharmacotherapy globally. | Am J Chin Med. 2021;49(5):1135-1150. doi: 10.1142/S0192415X21500543. Epub 2021 May 27. | Insomnia | Review |
| 34049475 | The aim of this paper is to assess the effect of acupuncture on insomnia. | Am J Chin Med. 2021;49(5):1135-1150. doi: 10.1142/S0192415X21500543. Epub 2021 May 27. | Insomnia | Review |
| 34049475 | In the subsequent quantitative meta-analysis of studies comparing acupuncture versus pharmacotherapy, fifteen RCTs demonstrated that acupuncture had a significant effect on patients with insomnia as assessed by the Pittsburgh sleep quality index (PSQI) (RR: -0.74; 95% CI: -1.07 to -0.40; [Formula: see text] inverted exclamation mark0.0001; [Formula: see text] = 89%; [Formula: see text] = 1475). | Am J Chin Med. 2021;49(5):1135-1150. doi: 10.1142/S0192415X21500543. Epub 2021 May 27. | Insomnia Sleep Quality | Review |
| 34049475 | A subgroup analysis showed that there was no significant effect after weeks 1 and 2, but six studies found that acupuncture had a significant effect insomnia at week 3 (RR: -0.97; 95% CI: -1.65 to -0.28; [Formula: see text] = 0.006; [Formula: see text] = 91%; [Formula: see text] = 463) and nine studies demonstrated a significant effect at week 4 (RR: -0.70; 95% CI: -1.15 to -0.25; [Formula: see text] = 0.002; [Formula: see text] = 85%; [Formula: see text] = 594). | Am J Chin Med. 2021;49(5):1135-1150. doi: 10.1142/S0192415X21500543. Epub 2021 May 27. | Insomnia | Review |
| 34049475 | These results suggest that insomnia patients may experience significant improvement in symptoms after more than three weeks of acupuncture treatment compared to pharmacological treatments. | Am J Chin Med. 2021;49(5):1135-1150. doi: 10.1142/S0192415X21500543. Epub 2021 May 27. | Insomnia | Review |
| 34274814 | Efficacy of intradermal acupuncture for insomnia: a meta-analysis. | Sleep Med. 2021 Sep;85:66-74. doi: 10.1016/j.sleep.2021.06.034. Epub 2021 Jun 29. | Insomnia | Review |
| 34274814 | OBJECTIVES: To provide updated evidence from randomized controlled trials (RCTs) on the efficacy of intradermal acupuncture for insomnia. | Sleep Med. 2021 Sep;85:66-74. doi: 10.1016/j.sleep.2021.06.034. Epub 2021 Jun 29. | Insomnia | Review |
| 34498795 | The efficacy of acupuncture on the sleep structure of patients with insomnia: A systematic review and meta-analysis. | Anat Rec (Hoboken). 2021 Nov;304(11):2412-2425. doi: 10.1002/ar.24745. Epub 2021 Sep 9. | Insomnia | Review |
| 34498795 | This study aims to evaluate the efficacy of acupuncture on the sleep structure of patients with insomnia, so as to provide a valuable basis for the effectiveness of acupuncture in the treatment of insomnia. | Anat Rec (Hoboken). 2021 Nov;304(11):2412-2425. doi: 10.1002/ar.24745. Epub 2021 Sep 9. | Insomnia | Review |
| 34498795 | We conducted searches based on MeSH terms and free words in Cochrane Library, PubMed, Web of science, CKNI (China Knowledge Resource Integrated Database), WanFang Database, and Chongqing VIP Information from the inception of these database until 10 July 2020 for randomized controlled trials (RCTs) that investigated acupuncture treatment in patients with insomnia, and pertinent details of the results were saved. | Anat Rec (Hoboken). 2021 Nov;304(11):2412-2425. doi: 10.1002/ar.24745. Epub 2021 Sep 9. | Insomnia | Review |
| 35305527 | Furthermore, complementary alternative medicines (CAMs) like mindfulness-based practices, acupuncture, listening to music, Yogasanas, Pranayama, digital cognitive behavioral therapy for insomnia (dCBTI) during bedtime proved supportive in insomnia disorder treatment. | Sleep Med. 2022 Mar;91:124-140. doi: 10.1016/j.sleep.2022.02.018. Epub 2022 Mar 1. | Insomnia | Review |
| 35405419 | Comparative effectiveness of multiple acupuncture therapies for primary insomnia: a systematic review and network meta-analysis of randomized trial. | Sleep Med. 2022 May;93:39-48. doi: 10.1016/j.sleep.2022.03.012. Epub 2022 Mar 24. | Insomnia | Review |
| 35405419 | BACKGROUND: Acupuncture has been widely practiced for primary insomnia (PI). | Sleep Med. 2022 May;93:39-48. doi: 10.1016/j.sleep.2022.03.012. Epub 2022 Mar 24. | Insomnia | Review |
| 35405419 | CONCLUSIONS: With moderate to low certainty of evidence, multiple acupuncture therapies showed impressive insomnia improvement, especially ACE, AP + MA, and EA + APA. | Sleep Med. 2022 May;93:39-48. doi: 10.1016/j.sleep.2022.03.012. Epub 2022 Mar 24. | Insomnia | Review |
| 35636168 | Acupuncture for cancer-related insomnia: A systematic review and meta-analysis. | Phytomedicine. 2022 Jul 20;102:154160. doi: 10.1016/j.phymed.2022.154160. Epub 2022 May 14. | Insomnia | Review |
| 35636168 | However, there is no meta-analytic synthesis explored the efficacy of acupuncture for cancer-related insomnia among cancer patients undergoing active cancer treatments. | Phytomedicine. 2022 Jul 20;102:154160. doi: 10.1016/j.phymed.2022.154160. Epub 2022 May 14. | Insomnia | Review |
| 35636168 | OBJECTIVE: This systematic review and meta-analysis were performed to explore the efficacy and safety of acupuncture for insomnia in people diagnosed with cancer. | Phytomedicine. 2022 Jul 20;102:154160. doi: 10.1016/j.phymed.2022.154160. Epub 2022 May 14. | Insomnia | Review |
| 35636168 | STUDY DESIGN: Systematic review and meta-analysis of existing randomized controlled trials on acupuncture in the treatment of cancer-related insomnia. | Phytomedicine. 2022 Jul 20;102:154160. doi: 10.1016/j.phymed.2022.154160. Epub 2022 May 14. | Insomnia | Review |
| 35636168 | CONCLUSION: Acupuncture has great potential to be used to manage cancer-related insomnia for cancer patients or survivors. | Phytomedicine. 2022 Jul 20;102:154160. doi: 10.1016/j.phymed.2022.154160. Epub 2022 May 14. | Insomnia | Review |
| 35636168 | More studies with rigorous designs and larger sample size are warranted to verify the efficacy and safety of acupuncture for insomnia among people diagnosed with cancer, in particular among those with clinically significant insomnia. | Phytomedicine. 2022 Jul 20;102:154160. doi: 10.1016/j.phymed.2022.154160. Epub 2022 May 14. | Insomnia | Review |
| 36099656 | Acupuncture showed effective on systemic conditions in relation to different cancers, including cancer-related pain (17 SRs, 80 RCTs), fatigue (7 SRs, 18 RCTs), insomnia (4 SRs, 10 RCTs), quality of life (2 SRs, 15 RCTs); conditions in relation to chemo-radiotherapy, including nausea and vomiting (3 SRs, 36 RCTs) and bone marrow suppression (2 SRs, 21 RCTs); and conditions in relation to specific cancers, including breast cancer-related menopause (3 SRs, 6 RCTs), hot flashes (12 SRs, 13 RCTs), arthralgia (5 SRs, 10 RCTs), and nasopharyngeal cancer-related dysphagia (1 SRs, 7 RCTs). | Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. | Insomnia Nausea and Vomiting | Review |
| 36099656 | CONCLUSION: Evidence from SRs showed that acupuncture is beneficial to cancer survivors with cancer-related pain, fatigue, insomnia, improved quality of life, nausea and vomiting, bone marrow suppression, menopausal symptoms, arthralgia, and dysphagia, and may also be potential for lymphoedema, gastrointestinal function, and xerostomia. | Phytomedicine. 2022 Nov;106:154430. doi: 10.1016/j.phymed.2022.154430. Epub 2022 Sep 5. | Insomnia Nausea and Vomiting | Review |
| 36764782 | Acupuncture as an Adjunct Treatment to Cognitive-Behavioral Therapy for Insomnia. | Sleep Med Clin. 2023 Mar;18(1):113-122. doi: 10.1016/j.jsmc.2022.10.005. | Insomnia | Review |
| 36764782 | The rationale for combining CBT-I treatment with acupuncture is explored, and evidence supporting its use in treating insomnia and related comorbidities is discussed. | Sleep Med Clin. 2023 Mar;18(1):113-122. doi: 10.1016/j.jsmc.2022.10.005. | Insomnia | Review |
| 36764782 | Growing evidence supports the effectiveness of acupuncture in treating insomnia and comorbid conditions, and warrants further investigation of acupuncture as an adjunct to CBT-I. | Sleep Med Clin. 2023 Mar;18(1):113-122. doi: 10.1016/j.jsmc.2022.10.005. | Insomnia | Review |
| 37199212 | CONCLUSION: Auriculotherapy has certain curative advantages in treatment of insomnia compared with western and Chinese medications as well as conventional acupuncture. | Zhongguo Zhen Jiu. 2022 Oct 12;42(10):1184-94. doi: 10.13703/j.0255-2930.20210706-0004. | Insomnia | Review |
| 37382085 | Currently, there is already evidence of the use of acupuncture for the treatment of nausea and vomiting, fatigue, dry mouth, anxiety, depression, insomnia and pain. | J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. | Insomnia Nausea and Vomiting Anxiety Depression | Review |
| 37382085 | METHODS: Structured and organised according to PICO standards, using keywords (""cancer"" OR ""malignant tumour"" OR ""chemotherapy"" OR ""radiotherapy"") AND (""acupuncture"" OR ""electroacupuncture"") AND (""pain"" OR ""nausea"" OR ""vomit"" OR ""fatigue"" OR ""xerostomia"" OR ""insomnia"" OR ""depression"" OR ""neuropathy""). | J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. | Insomnia Nausea and Vomiting Depression | Review |
| 37382085 | CONCLUSION: Based on this analysis, it is concluded that acupuncture is safe and there is evidence of the reduction of gastrointestinal symptoms, chemotherapy-induced peripheral neuropathy, pain, dry mouth, fatigue, insomnia, and improvement of cognitive capacity. | J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. | Neuropathic Pain Insomnia | Review |
| 37499485 | For the PSQI scores, we found the sequence of intervention measures by effect to be as follows: electroacupuncture, acupuncture, repetitive transcranial magnetic stimulation (rTMS), essential oils, herbal medicine, traditional Western medicine, Tai Chi and Baduanjin, music, supplements, cognitive behavioral therapy for insomnia (CBT-I), and exercise. | J Psychiatr Res. 2023 Sep;165:140-149. doi: 10.1016/j.jpsychires.2023.07.004. Epub 2023 Jul 23. | Insomnia | Review |
| 37527850 | Acupuncture, rTMS and mind-body exercises significantly improved sleep quality and insomnia severity but effects on objectively assessed outcomes were inconclusive. | J Sleep Res. 2023 Dec;32(6):e13979. doi: 10.1111/jsr.13979. Epub 2023 Aug 1. | Insomnia Sleep Quality | Review |
| 38060095 | Nausea/vomiting, fatigue, and insomnia may be relieved by acupuncture, mind-body, touch therapy, and certain dietary supplements. | Curr Oncol Rep. 2023 Dec;25(12):1523-1534. doi: 10.1007/s11912-023-01476-4. Epub 2023 Dec 7. | Insomnia Nausea and Vomiting | Review |
| 8726127 | Acupuncture treatment for insomnia and acupuncture analgesia. | Psychiatry Clin Neurosci. 1995 May;49(2):119-20. doi: 10.1111/j.1440-1819.1995.tb01874.x. | Insomnia | Review |
| 8726127 | Acupuncture is a simple and useful treatment for insomnia, with a success rate of around 90%. | Psychiatry Clin Neurosci. 1995 May;49(2):119-20. doi: 10.1111/j.1440-1819.1995.tb01874.x. | Insomnia | Review |
| 8726127 | The possible neuronal integration and transmitter effect in the acupuncture treatment for insomnia are discussed. | Psychiatry Clin Neurosci. 1995 May;49(2):119-20. doi: 10.1111/j.1440-1819.1995.tb01874.x. | Insomnia | Review |
| 23067573 | Based on the results of our review, acupuncture appears to be effective for treating headaches and, although more research is needed, seems to be a promising treatment option for anxiety, sleep disturbances, depression and chronic pain. | Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. | Insomnia Anxiety Depression | Review |
| 23067573 | Because acupuncture has been found to be effective in treating several individual conditions that form TSR (that is, insomnia, depression, chronic pain, headaches) and other multiple co-morbidities), it could be potentially advantageous for treating the multi-symptom complex of TSR. | Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. | Insomnia Depression | Review |
| 23067573 | Based on this literature pool, acupuncture appears to be relatively safe, and, as such, a weak recommendation is made for the treatment of sleep disturbances, although no firm conclusions can be drawn yet. | Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. | Insomnia | Review |
| 23067573 | Although more quality research and safety information are needed to determine whether acupuncture is useful in treating TSR components (.that is, PTSD, sexual function, cognitive function, fatigue), the results of our review suggest that acupuncture may be a beneficial or promising treatment for some components (that is., headache, anxiety, sleep disturbances, depression, chronic pain) and not beneficial for others (that is, substance abuse). | Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. | Cognitive Function Insomnia Anxiety Depression | Review |
| 23067573 | Though more research is needed to determine whether acupuncture is useful in treating anxiety, sleep disturbances, depression and chronic pain, it does seem to be a promising treatment option. | Syst Rev. 2012 Oct 15;1:46. doi: 10.1186/2046-4053-1-46. | Insomnia Anxiety Depression | Review |
| 24716183 | Recent advances from published clinical trials have added evidence to support the use of acupuncture for management of symptoms such as pain, nausea and vomiting, xerostomia, hot flashes, fatigue, anxiety, depression, and insomnia. | J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. | Insomnia Nausea and Vomiting Anxiety Depression | Review |
| 24716183 | Further methodologically strong, randomized controlled studies with a large sample size are needed to assess the usefulness of acupuncture for cancer-related fatigue and insomnia. | J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. | Insomnia | Review |
| 25886561 | Auricular acupuncture with seed or pellet attachments for primary insomnia: a systematic review and meta-analysis | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | We conducted a systematic review of the auricular therapy, aiming to evaluate whether there are advantages of auricular acupuncture with seed or pellet attachments for the treatment of primary insomnia. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | Statistical analyses of the outcomes revealed a positive effect of auricular acupuncture for primary insomnia. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | Nonetheless, considering the poor methodological quality, insufficient sample size and possible publication bias, current evidence is not yet adequate to provide a strong support for the use of auricular acupuncture in the treatment of primary insomnia. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | To date, many studies on auricular acupuncture for insomnia have been published worldwide. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | It is therefore worthwhile to conduct a systematic review with a more rigorous inclusion criteria and evidence rating system, aiming to evaluate the advantages of auricular acupuncture with seed or pellet attachments in the treatment of primary insomnia in a more explicit manner. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | Previous systematic reviews on auricular acupuncture for insomnia all reported that evidence was inadequate to make a firm conclusion. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | Our findings suggest auricular acupuncture is beneficial to primary insomnia sufferers in respect of sleep quality and quantity. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia Sleep Quality | Review |
| 25886561 | More strictly designed clinical trials are required in order to facilitate an explicit conclusion on the benefits of auricular acupuncture for primary insomnia. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | With minimal consumption of medical resources, auricular acupuncture could be integrated into routine care for insomnia without difficulty in a wide range of clinical settings. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 25886561 | In this review, meta-analyses of all included studies revealed a positive effect of auricular acupuncture for primary insomnia, however the poor methodological quality, insufficient sample size and possible publication bias of these studies mean that the evidence is not yet adequate to provide a strong support for the therapy in primary insomnia management. | BMC Complement Altern Med. 2015 Apr 2;15:103. doi: 10.1186/s12906-015-0606-7. | Insomnia | Review |
| 26945382 | Effectiveness of acupuncture and related therapies for managing anorexia, reducing constipation, paresthesia and dysesthesia, insomnia, and limb edema in cancer patients is uncertain, warranting future RCTs in these areas. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Insomnia | Review |
| 26945382 | Clinical evidence on the potential effectiveness of acupuncture and related therapies for controlling fatigue, paresthesia and dysesthesias, chronic pain, anorexia, insomnia, limb edema, and constipation should be synthesized. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Insomnia | Review |
| 26945382 | The objective of this study is to evaluate current best evidence on the potential role of acupuncture and related therapies in managing common cancer symptoms that pose substantial challenges to conventional care, including fatigue, paresthesia and dysesthesias, chronic pain, anorexia, insomnia, limb edema, constipation, and health-related quality of life. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Insomnia | Review |
| 26945382 | On the other hand, available evidence did not show any differences on the following comparisons: the combined use of acupuncture and conventional care versus conventional care alone for treating anorexia; acupuncture and related therapies versus conventional medicine for reducing constipation, paresthesia and dysesthesia; and acupressure or acupressure plus essential oil versus sham acupressure for improving insomnia. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Insomnia | Review |
| 26945382 | The effectiveness of acupuncture and related therapies in treating anorexia, constipation, paresthesia and dysesthesia, insomnia, and limb edema in cancer patients is unclear. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Insomnia | Review |
| 27358589 | Numerous clinical trials of acupuncture indicate its potential role in fighting the following ailments: nausea and chemotherapy-induced vomiting, pain, xerostomia, vasomotor symptoms, neutropenia, fatigue, anxiety, insomnia, lymphoedema after mastectomy, and peripheral neuropathy. | Contemp Oncol (Pozn). 2016;20(2):119-23. doi: 10.5114/wo.2016.60065. Epub 2016 Jun 14. | Insomnia Nausea and Vomiting Anxiety | Review |
| 27430619 | Acupuncture for insomnia after stroke: a systematic review and meta-analysis | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Acupuncture has increasingly been used for insomnia relief after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | The aim of the present study was to summarize and evaluate evidence on the effectiveness of acupuncture in relieving insomnia after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Randomized controlled trials (RCTs) were included if acupuncture was compared to placebo or other conventional therapy for treatment of insomnia after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Our results suggest that acupuncture could be effective for treating insomnia after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Acupuncture has been widely used to treat a variety of clinical conditions, particularly those involving pathological changes in neuroendocrinology, such as menopause, depression, and insomnia. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia Depression | Review |
| 27430619 | Many published clinical studies, including randomized controlled trials (RCTs), have explored acupuncture as a treatment for insomnia. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Most reports have demonstrated positive clinical effects of acupuncture in the treatment of insomnia. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | A few recent systematic reviews have examined the effectiveness of acupuncture in the treatment of insomnia. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Furthermore, the effectiveness of acupuncture in treating insomnia after stroke has not been fully determined. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | The aim of the present study was to summarize and evaluate evidence on the effectiveness of acupuncture for insomnia relief after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Trials were excluded if the study design did not allow evaluation of the effects of acupuncture on insomnia after stroke; that is, studies were excluded if they 1) compared different types of acupuncture, 2) adopted complex treatment without examining the effects of acupuncture alone, or 3) reported insufficient information. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | A total of 33 acupuncture points (24 meridian points and nine auricular acupuncture points) were used for the treatment of insomnia. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Meta-analysis of acupuncture for insomnia after stroke according to different assessment tools | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | The present review suggested that compared to drug treatment, acupuncture might be an effective treatment for insomnia after stroke, and that compared to sham treatment, intradermal acupuncture might have significant effects on insomnia after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | The evidence has suggested that the clinical efficacy of acupuncture in the treatment of insomnia is potentially mediated by a variety of neurotransmitters, including norepinephrine, melatonin, gamma-aminobutyric acid, and beta-endorphin. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Huang reviewed not only clinical trials but also case series and demonstrated that acupuncture is potentially beneficial for the treatment of insomnia. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | The results of this study suggested that acupuncture could be effective in relieving insomnia after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27430619 | Further studies using large samples and a rigorous study design are needed to confirm the role of acupuncture in the treatment of insomnia after stroke. | BMC Complement Altern Med. 2016 Jul 19;16:228. doi: 10.1186/s12906-016-1220-z. | Insomnia | Review |
| 27531549 | Acupuncture for Managing Cancer-Related Insomnia: A Systematic Review of Randomized Clinical Trials | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | The aim of this systematic review was to assess the efficacy of acupuncture in the management of cancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Randomized controlled trials (RCTs) and quasi-RCTs were included if acupuncture was used as the sole intervention or as an adjunct to another standard treatment for any cancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Two RCTs tested the effects of acupuncture on cancer-related insomnia compared with sham acupuncture. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | There are 3 systematic reviews related to the effects of acupuncture on insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | One review yielded mixed evidence, while the other Cochrane systematic review showed that the acupuncture was not more effective than routine care with noncancer-related insomnia patients. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | The third review assessed the use of acupuncture in cancer care, including the treatment of insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | There has been no current systematic review that evaluated the clinical evidence of acupuncture for cancer-related insomnia specifically. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | The aims of this systematic review were to update, complete, and critically evaluate the efficacy of acupuncture in the management of cancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | The search terms included (acupuncture OR electro-acupuncture OR meridian) AND (cancer OR tumour OR neoplasms OR malignancy OR carcinoma) AND (sleep disorder OR sleep disturbance OR insomnia OR wakefulness OR waking) in Korean, Chinese, and English. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | RCTs were included if acupuncture was used as the sole intervention or as an adjunct to another standard treatment for any cancer-related insomnia and if the control group received the same concomitant treatments as the acupuncture group. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Trials were included if acupuncture was used as the sole intervention or as an adjunct to another standard treatment for any insomnia in patients with cancer and if the control group received the same concomitant treatments as the acupuncture group. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | One RCT that used a logbook for night sleep disturbance showed favorable effects of acupuncture, whereas the other RCT failed to show beneficial effects of electro-acupuncture on sleep quality score based on PSQI. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia Sleep Quality | Review |
| 27531549 | Two RCTs showed the equivalent effects of acupuncture on the cancer-related insomnia response rate after 1 week of treatment. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | One RCT tested the effects of acupuncture on cancer-related insomnia compared with hormone therapy. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Few rigorous trials have tested the effects of acupuncture for managing cancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | The totality of the evidence from acupuncture RCTs for managing cancer-related insomnia is mixed according to the type of cancer and the acupuncture and treatment regimens. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | The newly added trials suggest more positive effects of acupuncture on cancer-related insomnia than the previous review. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | The results of systematic review of acupuncture for cancer-related insomnia are different from those of noncancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Two previous systematic reviews for noncancer-related insomnia showed mixed effects according to type of acupuncture and control groups, including high risk of bias studies. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Two sham acupuncture methods were used for testing the efficacy of acupuncture for cancer-related insomnia, including superficial penetrating needles at nonacupuncture points and nonpenetrating needles at nonacupuncture points. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | One trial showed favorable effects of manual acupuncture compared with penetrating needling at nonacupuncture points for cancer-related insomnia, but another trial failed to show superior effects of electro-acupuncture compared with the use of nonpenetrating needles at nonacupuncture points. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | For instance, the number of treatment sessions could have been too small to generate a significant effect, treatment could have been suboptimal, or the protocol applied in the acupuncture group might not have been suitable for treating cancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | There are also other issues regarding the use of acupuncture for cancer-related insomnia that should be discussed further. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Because cancer-related insomnia may develop in the setting of a highly heterogeneous cancer with a different etiology and severity, acupuncture is likely to have different effects on different subgroups of patients. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Future acupuncture RCTs on cancer-related insomnia should adhere to accepted standards of trial methodology. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | In conclusion, the current trials showed that acupuncture may be superior to sham acupuncture, conventional drug therapy and hormone therapy for the management of cancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 27531549 | Future well-conducted RCTs are needed to determine whether acupuncture can be a viable option for the treatment of cancer-related insomnia. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Insomnia | Review |
| 28239282 | In our previous study we summarized possible use of acupuncture in management of cancer symptoms and treatment-related ailments, such as chemotherapy-induced nausea and vomiting, pain, xerostomia, vasomotor symptoms, neutropenia, fatigue, anxiety, insomnia, lymphoedema after mastectomy and peripheral neuropathy. | Contemp Oncol (Pozn). 2016;20(6):453-457. doi: 10.5114/wo.2016.65604. Epub 2017 Jan 12. | Insomnia Nausea and Vomiting Anxiety | Review |
| 28286776 | The Efficacy of Acupuncture for Treating Depression-Related Insomnia Compared with a Control Group: A Systematic Review and Meta-Analysis | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | To evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | This systematic review indicates that acupuncture could be an alternative therapy to medication for treating depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | Cheuk DKL's systematic review and meta-analysis of acupuncture treatment for patients with insomnia showed that acupuncture treatment was better in improving sleep quality, decreasing sleep latency, and prolonging total sleep time, compared with the control group. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Sleep Quality | Review |
| 28286776 | The purpose of this meta-analysis was to evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | Acupuncture is widely used in the treatment of depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | A large number of studies have reported that acupuncture treatment is effective in treating depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | This systematic review and meta-analysis on the acupuncture treatment for depression-related insomnia can find some results. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | In this systematic review and meta-analysis, we further evaluated the effectiveness of acupuncture in the treatment of depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | The flowing search terms were used: acupuncture/electroacupuncture/EA and insomnia/sleep disorders and depression. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | By reading full texts of the published studies, 18 studies were confirmed that they were all randomized controlled trials of acupuncture treating insomnia associated with depression (Table 1), among them 11 articles were RCTs of acupuncture compared with Western medicine; 5 were RCTs of acupuncture combined with medication compared with sole medication; 2 were studies of acupuncture compared with sham or placebo acupuncture control. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | It indicates that the acupuncture treatment was more effective on insomnia and depression than medication (Figure 3). | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | This systematic review and meta-analysis assessed the effectiveness of acupuncture in treating depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | The object of this systematic review and meta-analysis is to evaluate the effectiveness of acupuncture in treating depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | We found that, compared to medication, acupuncture treatment was effective in improving depression-related insomnia and depression degree. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | In conclusion, research evidence supported the use of acupuncture as an effective treatment to improve symptoms of depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28286776 | In addition, the use of acupuncture should be considered an appropriate alternative treatment for depression-related insomnia. | Biomed Res Int. 2017;2017:9614810. doi: 10.1155/2017/9614810. Epub 2017 Feb 14. | Insomnia Depression | Review |
| 28459738 | Acupuncture has been investigated in the treatment of cancer-related pain that is insufficiently controlled by analgesics, as well as for cancer-related insomnia and breast-cancer related hot flashes. | Curr Opin Oncol. 2017 Jul;29(4):235-242. doi: 10.1097/CCO.0000000000000376. | Insomnia | Review |
| 28930222 | in 2013 on insomnia considered a number of studies evaluating the effectiveness of somatic acupuncture and of auriculotherapy in cancer patients with positive results for both techniques. | Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. | Insomnia | Review |
| 28930222 | According to the authors, the studies on insomnia are difficult to interpret owing to confounding factors that are often present, but the data available show the sedative and hypnotic effects of acupuncture when it is used in the treatment of insomnia and nervousness. | Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. | Insomnia | Review |
| 29234418 | Acupuncture stimulation at HT7 (Sinmun) has been clinically used to treat cognitive impairment and sleep disturbances (Figure 1) and is considered a useful therapy for memory impairment. | Evid Based Complement Alternat Med. 2017;2017:6512520. doi: 10.1155/2017/6512520. Epub 2017 Sep 27. | Insomnia | Review |
| 29234450 | According to the report released by the World Health Organization (WHO), more than 40 disorders, including stress and insomnia, can benefit from acupuncture treatment. | Evid Based Complement Alternat Med. 2017;2017:9785345. doi: 10.1155/2017/9785345. Epub 2017 Oct 18. | Insomnia | Review |
| 30151019 | One study of electroacupuncture (n=76) reported on quality of life using a modified Edmonton Symptom Assessment System (ESAS) which consists of five items (pain, nausea, insomnia, abdominal distension, and general sense of well-being), which are each rated using a 0-10 numeric rating scale. | Evid Based Complement Alternat Med. 2018 Jul 29;2018:3178472. doi: 10.1155/2018/3178472. eCollection 2018. | Insomnia Nausea and Vomiting | Review |
| 30416533 | Although few clinical studies have investigated the effect of acupuncture on brain neurotransmitter levels, it has been shown that acupuncture reduced serum norepinephrine levels and increased serum levels of glutamate, 5-HT, and BDNF in insomnia patients, suggesting that serum BDNF has been implicated in the sedative effect of acupuncture. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Insomnia | Review |
| 30622598 | The results showed that acupuncture could be more beneficial than no treatment/sham acupuncture in terms of changes in craving for opioid (MD -2.18, 95% CI -3.10 to -1.26), insomnia (MD 2.31, 95% CI 1.97 to 2.65), and depression (SMD -1.50, 95% CI -1.85 to -1.15). | Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. | Insomnia Depression | Review |
| 30622598 | In addition, these findings showed that, compared to sham electroacupuncture (EA), EA had differences in alleviating symptoms of craving (SMD -0.50, 95% CI -0.94 to -0.05) and depression (SMD -1.07, 95% CI -1.88 to -0.25) and compared to sham transcutaneous acupoint electrical stimulation (TEAS), TEAS had differences in alleviating symptoms of insomnia (MD 2.31, 95% CI 1.97 to 2.65) and anxiety (MD -1.26, 95% CI -1.60 to -0.92) compared to no treatment/sham TEAS. | Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. | Insomnia Anxiety Depression | Review |
| 30622598 | The objective of this study is to assess the efficacy of various modes of acupuncture in OUD through intensity of withdrawal syndrome; duration of treatment; urine examination; intensity of pain, anxiety, depression, insomnia, and other associated symptoms; retention of treatment; and nature and rate of adverse effect. | Evid Based Complement Alternat Med. 2018 Dec 2;2018:3724708. doi: 10.1155/2018/3724708. eCollection 2018. | Adverse Reactions Insomnia Anxiety Depression | Review |
| 30762783 | As an alternative or complementary treatment, acupuncture and moxibustion are considered helpful in improving symptoms of insomnia. | Medicine (Baltimore). 2019 Feb;98(7):e14509. doi: 10.1097/MD.0000000000014509. | Insomnia | Review |
| 30762783 | Control group will include common acupuncture as intervention measures, and sedative-hypnotic medicine for insomnia will be taken into consideration. | Medicine (Baltimore). 2019 Feb;98(7):e14509. doi: 10.1097/MD.0000000000014509. | Insomnia | Review |
| 30762783 | FNM is the combination of acupuncture with moxibustion, which has been applied in numerous clinical conditions, including insomnia and psychiatric disorders. | Medicine (Baltimore). 2019 Feb;98(7):e14509. doi: 10.1097/MD.0000000000014509. | Insomnia | Review |
| 30809158 | A recent meta-analysis that included 18 randomized clinical trials (RCTs) involved 1,678 adults given acupuncture for depression-related insomnia and found significant improvements in sleep quality with acupuncture compared with Western medicine. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Insomnia Depression Sleep Quality | Review |
| 30809158 | When acupuncture was given as an adjunctive therapy with Western medicine, both depression and insomnia were improved. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Insomnia Depression | Review |
| 30809158 | However, in another RCT involving 150 patients with residual insomnia associated with MDD, traditional acupuncture needling produced only mild treatment effects that were similar to those of minimal acupuncture and placebo acupuncture. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Insomnia | Review |
| 30809158 | Thus, the psychological effect of acupuncture might play an important role in the treatment of acupuncture in depression-related insomnia. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Insomnia Depression | Review |
| 30809158 | Acupuncture may also be of benefit in anxiety-related insomnia. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Insomnia Anxiety | Review |
| 30809158 | A Canadian study reported that acupuncture significantly improved sleep quality in patients with anxiety and insomnia. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Insomnia Anxiety Sleep Quality | Review |
| 30809158 | Combined with the evidence of treatment efficacy in depression-related insomnia, acupuncture may have broader utility in neuropsychiatric disorders with impaired quality of sleep. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Insomnia Depression Sleep Quality | Review |
| 30813193 | The randomized controlled trials of auriculotherapy (auricular acupuncture and auricular acupressure) for patients with primary insomnia will be included. | Medicine (Baltimore). 2019 Feb;98(8):e14621. doi: 10.1097/MD.0000000000014621. | Insomnia | Review |
| 31016194 | Unlike the efficacy of acupuncture on other depression diseases such as major depressive disorder and post-stoke depression or even depression related insomnia, the treatment efficacy of acupuncture on postpartum women was lower compared to other treatment methods. | Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. | Insomnia Depression | Review |
| 31118954 | Effect of acupuncture treatment on insomnia was studied by Bo et al. | Evid Based Complement Alternat Med. 2019 Apr 16;2019:3051472. doi: 10.1155/2019/3051472. eCollection 2019. | Insomnia | Review |
| 31118954 | They used parachlorophenylalanine-induced insomnia rat models and performed Mongolian medial warm acupuncture treatment. | Evid Based Complement Alternat Med. 2019 Apr 16;2019:3051472. doi: 10.1155/2019/3051472. eCollection 2019. | Insomnia | Review |
| 31374032 | There is a clinical basis for ear acupuncture, which may be effective for immediate pain relief, as well as psychiatric conditions such as substance abuse, insomnia, depression, and anxiety. | Medicine (Baltimore). 2019 Aug;98(31):e16631. doi: 10.1097/MD.0000000000016631. | Pain Relief Insomnia Anxiety Depression | Review |
| 31438914 | Research trends of acupuncture therapy on insomnia in two decades (from 1999 to 2018):a bibliometric analysis | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | We aimed to evaluate the global scientific output of research of acupuncture on insomnia and explore the hotspots and frontiers from 1999 to 2018, by using bibliometric methods. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Articles about acupuncture therapy on insomnia were retrieved from the Web of Science Core Collection (WoSCC). | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Until August 31, 2018 31, 2018, a total of 292 records in acupuncture therapy on insomnia research were identified from 1999 to 2018. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | As one of complementary treatment modalities, previous studies have shown that acupuncture has hypnotic effects, especially in primary insomnia, depression-related insomnia, and cancer-related insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia Depression | Review |
| 31438914 | To gain insights into research trend and hot spots in the field of acupuncture therapy on insomnia, we performed a bibliometric analysis of articles from 1998 to 2018 by using CiteSpace V. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Then, we combined the first query and the second query to find documents focused on the acupuncture in insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | The annual number of publication on acupuncture in insomnia | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | From the trend of the number, we can see that more research is being carried out on the acupuncture therapy in insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | cited journal map of acupuncture for insomnia | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | In this article,evidences were provided to suppot the treatment of acupuncture therapy for chronic insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | As the second country in the ranking list (Table 3), USA got 70 records which meaned the widely use of acupuncture in the treatment of insomnia in this country. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | From the citations, more and more randomized and controlled trials were conducted to support the efficiency of acupuncture therapy in insomnia . | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | In 26 institutes which paied close attention in the field of acupuncture therapy in insomnia, the top 3 institutes were in Hong Kong (Table 3). | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Author and cited-author map of acupuncture for insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | a The network map of author related to acupuncture for insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | b The network map of cited author related to acupuncture for insomnia | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Most of them came from the University of Hong Kong and a research team has been established to specialize in the field of acupuncture therapy for insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | A prepost clinical trial study was conducted by his team to identify the effective of acupuncture treatment to anxious patients with insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | In residual insomnia associated with major depressive disorder and primary insomnia, slight advantages were found of electroacupuncture compared with placebo acupuncture. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | And the other paper published by CHEN HY focused on the efficacy and safety of auricular acupuncture treatment for insomnia through meta analysis. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Cited reference map of acupuncture for insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | a The network map of cited reference related to acupuncture for insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | b The timeline view of cited reference related to acupuncture for insomnia | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Electroacupuncture and acupressure are the common type of acupuncture therapy to treat insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | In primary insomnia and chronic insomnia, electroacupuncture had beneficial effect on sleep quality and the safety. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia Sleep Quality | Review |
| 31438914 | Keyword map of acupuncture for insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | a The network map of keyword related to acupuncture for insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | b The timezone view of keyword related to acupuncture for insomnia | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | Using CiteSpace, bibliometric analysis of acupuncture therapy on insomnia from 1998 to 2018 were calculated. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31438914 | In conclusion, this study provids a perspective to the developing trend and hot topics of acupuncture therapy on insomnia. | BMC Complement Altern Med. 2019 Aug 22;19(1):225. doi: 10.1186/s12906-019-2606-5. | Insomnia | Review |
| 31497504 | Acupuncture using pattern-identification for the treatment of insomnia disorder: a systematic review and meta-analysis of randomized controlled trials | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | Although there are some systematic reviews that acupuncture has the benefit for insomnia, there is no systematic review on acupuncture using pattern identification. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | This review aimed for evaluating acupuncture efficacy using pattern-identification to treat insomnia. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | We carried out a comprehensive review of randomized controlled trials (from 2000 to April 12, 2018), using PubMed, Cochrane CENTRAL, EMBASE, CINAHL, PsycINFO, CNKI, and 3 Korean (OASIS, NDSL, RISS4U) databases, comparing acupuncture using pattern identification (only) with medication in primary insomnia. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | People with insomnia search for alternative and non-drug treatments including acupuncture. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | There are some previous systematic reviews on the efficacy of acupuncture for insomnia, and the authors concluded that acupuncture may be effective for primary insomnia. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | To date, there are few systematic reviews or meta-analyses regarding acupuncture using PI for the treatment of insomnia. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | One such review evaluated acupuncture for insomnia of Yin deficiency type. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | And many patients with chronic insomnia use medications that may not be effective and/or that may be harmful also seek complementary and alternatives and non-pharmacological intervention like acupuncture. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31497504 | Nevertheless, our result that acupuncture using PI had similar effects to medication is remarkable because many patients with chronic insomnia use medications seek acupuncture as a supplement or an alternative to their insomnia management and acupuncture using PI is widely used in actual clinical settings. | Integr Med Res. 2019 Sep;8(3):216-226. doi: 10.1016/j.imr.2019.08.002. Epub 2019 Aug 13. | Insomnia | Review |
| 31565065 | Efficacy Comparison of Different Acupuncture Treatments for Primary Insomnia: A Bayesian Analysis | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Acupuncture treatments are used frequently in the treatment of primary insomnia considering its less side effect. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Side Effects Insomnia | Review |
| 31565065 | This study compared the effectiveness of different forms of acupuncture for primary insomnia by using network meta-analysis. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | All randomized controlled trials (RCTs) of acupuncture treatments for primary insomnia were searched in seven databases from the date of database inception to January 6, 2019, including PubMed, Web of Science, Embase, Cochrane Library, Wanfang database, China National Knowledge Infrastructure (CNKI) database, and VIP Chinese Science and Technique Journals (CQVIP) database. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | The finding indicated that five acupuncture methods may be all effective in the treatment of primary insomnia, and scalp acupuncture seems to be the best treatment. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | In China, acupuncture is considered as an effective alternative treatment for insomnia because of its low side effects and easy availability. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Side Effects Insomnia | Review |
| 31565065 | As a safe and effective natural therapy, acupuncture therapy has been added to the latest version of Guidelines for the Diagnosis and Treatment of Insomnia in China by the China Sleep Research Association. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Meanwhile, many clinical randomized trials and systematic analysis have shown that a variety of acupuncture treatments are significantly better than drug therapy in primary insomnia. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | However, these previous studies have only demonstrated the effectiveness of single acupuncture treatment against their own control intervention for primary insomnia. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | This study was committed to comparing the effectiveness of different acupuncture treatments for primary insomnia and finding a better acupuncture treatment selection guideline for clinicians and patients. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | In the six treatments for primary insomnia included in this study, scalp acupuncture is considered to be the most effective method, followed by electroacupuncture, electroacupuncture combined scalp acupuncture, warm acupuncture, conventional acupuncture, and finally western medicine. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Most clinical studies and experimental studies have shown that acupuncture is effective for primary insomnia. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Thus, this study combines the results of the previous studies with network meta-analysis to compare the efficacy of different acupuncture methods in the treatment of primary insomnia and finally rank them according to the efficacy. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Before the study, we found that a previous protocol on the network meta-analysis of acupuncture for primary insomnia has been published. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Since ancient times, acupuncture has been used to treat primary insomnia in China. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Moreover, the modern biological mechanism of acupuncture treatment of primary insomnia is not fully revealed. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Studies have shown that acupuncture can regulate some insomnia by regulating some neurotransmitters, such as norepinephrine, serotonin, dopamine, acetylcholine, and γ-aminobutyric acid, and reducing glutamate levels. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Consistent with the above existing theory, scalp acupuncture is considered to be the best treatment for primary insomnia in this study. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | As a novel treatment using traditional acupuncture and modern medical cerebral cortical positioning theory, scalp acupuncture is a method of acupuncture treatment of certain areas of the scalp to treat primary insomnia. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | Future clinical studies can focus on studying the effects of specific acupoints on the treatment of insomnia, but this may be contradictory with the principle of acupuncture treatment based on syndrome differentiation. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31565065 | This study indicated that the included five acupuncture methods may be effective and safe in improving the condition of patients with primary insomnia, and scalp acupuncture seems to be a better treatment for primary insomnia. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Insomnia | Review |
| 31702639 | Effectiveness and safety of acupuncture for insomnia | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | At present, acupuncture has been proved effective in the treatment of insomnia by many studies. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | The purpose of this study is to evaluate the efficacy and safety of acupuncture in the treatment of insomnia, and to provide the latest evidence for clinical application. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | We collected the qualified literature on acupuncture treatment of insomnia by electronic retrieval of Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Disc (CBMDISC), PubMed, China Science and Technology Journal Database (VIP) and Wanfang Database, and manual retrieval of papers and internal reports. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | We use Insomnia Severity Index (ISI) as the main outcome of insomnia and Pittsburgh Sleep Quality Index (PSQI), Hamilton Depression Scale(HAMD) and Self-Rating Anxiety Scale (SAS) as secondary indicators to evaluate the efficacy and safety of acupuncture treatment of insomnia, we will use Revman v.5.3 software to calculate data synthesis, and if the results are appropriate, meta-analysis can also be carried out. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia Anxiety Depression Sleep Quality | Review |
| 31702639 | This study will provide comprehensive evidence of high quality of acupuncture treatment for insomnia from ISI, PSQI, HAMD, SAS, and adverse reactions. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Adverse Reactions Insomnia | Review |
| 31702639 | The systematic review will provide a basis for evaluating the efficacy and safety of acupuncture in the treatment of insomnia. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | Supplementary and alternative medical therapies have proposed several treatments for insomnia, including acupuncture, acupoint massage, aromatherapy, foot reflex therapy, homeopathy, meditation exercise therapy, moxibustion, music therapy, and yoga. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | Acupuncture, as one of the complementary and alternative medical therapies for insomnia, has been proved to be an effective method for insomnia in many clinical trials. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | Therefore, this article hopes to evaluate the efficacy and safety of acupuncture in the treatment of insomnia, and provide new evidence for clinical application. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | This study will be included in a randomized controlled trial (RCT) of acupuncture in the treatment of insomnia, whether using blind method or allocation concealment method. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | The search terms used in the systematic review are as follows: acupuncture, insomnia, Sleep disorder, budewo, budemian, and budeming. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | Search ((((Insomnia[Title/Abstract] OR Sleep disorder[Title/Abstract]))) AND (Acupuncture[Title/Abstract])), And similar search strategy will be applied to other electronic databases. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | When meta-analysis shows significant heterogeneity, we will subgroup analysis according to the type of insomnia and different methods of acupuncture. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | Acupuncture may be one of the alternative methods to treat insomnia, with little side effects. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Side Effects Insomnia | Review |
| 31702639 | At present, there are many reports that acupuncture has a significant effect on insomnia, but the safety of acupuncture in the treatment of insomnia is uncertain. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 31702639 | Therefore, it is necessary to conduct a high-quality systematic review and meta-analysis to systematically evaluate the published randomized controlled trials of acupuncture and moxibustion for insomnia and to provide objective evidence for its clinical application. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Insomnia | Review |
| 32080154 | For insomnia in patients with PTSD, although ear acupuncture improved a few subscales of the Pittsburgh sleep quality index in an RCT, other outcomes including sleep diary, actigraph, and the insomnia severity index were not improved. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia Sleep Quality | Review |
| 32080154 | There is also some clinical evidence of the effectiveness of ear acupuncture in psychiatric conditions such as substance abuse, insomnia, depression, and anxiety as well as immediate pain relief. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Pain Relief Insomnia Anxiety Depression | Review |
| 32080154 | In Prisco, an RCT, 35 PTSD veterans with insomnia related to combat stress received conventional care plus ear acupuncture, conventional care plus sham ear acupuncture, or conventional care alone for 8 weeks. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia | Review |
| 32080154 | In King, an RCT, 20 PTSD veterans with insomnia related to combat stress received conventional care plus ear acupuncture or conventional care alone for 3 weeks. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia | Review |
| 32080154 | In Cronin, a before-after study, 3 veterans with insomnia related to combat stress received ear acupuncture for 5 days. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia | Review |
| 32080154 | The benefits of the additional use of ear acupuncture for conventional care in veterans with both PTSD and insomnia associated with combat stress were examined in 2 RCTs. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia | Review |
| 32080154 | For insomnia in patients without diagnosed PTSD, ear acupuncture or ear acupressure had the effect of improving sleep quality as measured by PSQI. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia Sleep Quality | Review |
| 32080154 | Although our pre-defined protocol initially did not include insomnia-related outcomes, their importance was recognized during the study and the effects of ear acupuncture in insomnia patients with or without diagnosed PTSD as secondary outcomes was analyzed. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia | Review |
| 32080154 | Future researchers should design the study of ear acupuncture in disaster, considering that insomnia is an important clinical issue for survivors with or without diagnosed PTSD after a disaster. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Insomnia | Review |
| 32718258 | In another, gabapentin was used with acupuncture to treat anxiety attacks and sleep disturbances. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Insomnia Anxiety | Review |
| 33005199 | Acupuncture treatment (AT) has been widely used for poststroke rehabilitation, and many systematic review and meta-analysis studies have addressed the effects of acupuncture on poststroke complications such as shoulder pain, spasticity, depression, insomnia, and dysphagia. | Evid Based Complement Alternat Med. 2020 Sep 14;2020:4981945. doi: 10.1155/2020/4981945. eCollection 2020. | Insomnia Depression | Review |
| 33019448 | Effectiveness and safety of electroacupuncture for insomnia | Medicine (Baltimore). 2020 Oct 2;99(40):e22502. doi: 10.1097/MD.0000000000022502. | Insomnia | Review |
| 33019448 | Electro acupuncture (EA) is reported to be efficacious and widely used for the treatment of insomnia in China. | Medicine (Baltimore). 2020 Oct 2;99(40):e22502. doi: 10.1097/MD.0000000000022502. | Insomnia | Review |
| 33019448 | This overview aims to summarize the available evidence from current systematic reviews for the efficacy of electroacupuncture therapy for insomnia. | Medicine (Baltimore). 2020 Oct 2;99(40):e22502. doi: 10.1097/MD.0000000000022502. | Insomnia | Review |
| 33019448 | The following search terms will be used:Disorders of Initiating and Maintaining Sleep, Disorders of Initiating and Maintaining Sleep, Early Awakening, Nonorganic Insomnia, Insomnia, Primary Insomnia, Transient Insomnia, Rebound Insomnia, Secondary Insomnia, Sleep Initiation Dysfunction, Sleeplessness, Insomnia Disorder, Psychophysiological Insomnia, Electroacupuncture, Electroacupuncture, complementary therapy of electroacupuncture, Traditional Chinese therapy of electroacupuncture, systematic review, meta-analysis, et al. | Medicine (Baltimore). 2020 Oct 2;99(40):e22502. doi: 10.1097/MD.0000000000022502. | Insomnia | Review |
| 33380304 | Acupuncture has been demonstrated to have potential efficacy in animal models, and it has also been shown that low-frequency electroacupuncture (EA) stimulation of Feng-Chi acupoints improved epilepsy and epilepsy-induced sleep disruptions in the pilocarpine-induced rat epilepsy model, whereas 100 Hz EA of bilateral Feng-Chi acupoints exacerbated seizures and related sleep disturbances. | Curr Neuropharmacol. 2021;19(8):1264-1272. doi: 10.2174/1570159X19666201230142716. | Insomnia | Review |
| 33380304 | There are some RCTs that have revealed that acupuncture improves primary insomnia, insomnia after stroke, and sleep disturbances in patients with traumatic brain injury and post-traumatic stress disorder, etc., but it is not recommended for the treatment of insomnia in European guidelines may be due to its poor evidence. | Curr Neuropharmacol. 2021;19(8):1264-1272. doi: 10.2174/1570159X19666201230142716. | Insomnia | Review |
| 33408601 | Mounting evidence supports that acupuncture provides satisfactory effects for various neuropsychiatric disorders including vascular dementia (Yu et al.,; Xiao et al.,), depression (Wang et al.,), and insomnia (Yin et al.,). | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Insomnia Depression | Review |
| 33498883 | These would be, for acupuncture and auriculotherapy, a decrease in the occurrence of postsurgical constipation; for laser moxibustion, a decrease in cancer-related fatigue; for hypnosis, an improvement in fatigue, sleep disturbance and pain, coinciding with the results of other authors concerning the pain-decrease effect; and for Ayurveda, a decrease in the occurrence of radiodermatitis and an improvement of its symptoms. | Int J Environ Res Public Health. 2021 Jan 24;18(3):1017. doi: 10.3390/ijerph18031017. | Insomnia | Review |
| 33584374 | Studies comparing any two of the following non-pharmacological interventions proposed in the most recent international guideline for elderly individuals with insomnia were included irrespective of the form (e.g., group or individual) and duration of treatment: cognitive behavioral therapy (CBT), behavioral treatment (BT) including multi-component behavioral treatments for insomnia, sleep hygiene only (including sleep education), sleep restriction only, stimulus control only, relaxation therapy (including meditation), exercise (including walking and weight training), Tai Chi (including qigong), and acupuncture (including acupressure). | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | In other words, combined treatments such as acupuncture combined with benzodiazepines and benzodiazepines combined with CBT-I showed excellent effectiveness in improving insomnia in the elderly. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | However, some previously published studies suggest that CBT-I, known as the first-line treatment for insomnia, and acupuncture may have different therapeutic characteristics. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | These studies have found that acupuncture showed weaker effects of improving insomnia itself compared to CBT-I, but showed an excellent effect in improving accompanying conditions, especially pain and pain-related insomnia. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | Although acupuncture may still need more solid evidence to be recommended for routine treatment of elderly individuals with insomnia, the treatment seems to be useful as an adjuvant strategy to complement conventional treatments. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | Also, given the high prevalence of pain in the elderly, acupuncture may have the potential to improve both pain-related insomnia and pain condition in this population. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | For example, acupuncture may be an important treatment component for patients with insomnia and pain or with poor cognitive status. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | This review found that acupuncture may be a promising adjuvant for elderly individuals with insomnia. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | However, different methods of acupuncture can also have different effects on insomnia. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | For example, a recent NMA with Bayesian analysis analyzed 52 RCTs and concluded that scale acupuncture is most effective for treating primary insomnia. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | Therefore, in future studies, expert consensus about the most effective acupuncture methods for treating elderly individuals with insomnia in clinical settings should be derived, and acupuncture trials based on the standardized acupuncture methods should be conducted. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33584374 | Given that the cost-effectiveness of this treatment has been demonstrated in various clinical conditions, the cost-effectiveness of interventions, including acupuncture for elderly individuals with insomnia, should be further investigated. | Front Psychiatry. 2021 Jan 28;11:608896. doi: 10.3389/fpsyt.2020.608896. eCollection 2020. | Insomnia | Review |
| 33586504 | Given that this meta-analysis has shown that acupuncture is effective, perhaps in the future, all clinical and methodological experts should focus on finding a proper sham-acupuncture intervention to be used in acupuncture trials to concretely and scientifically show the effects of acupuncture; then, the medical community would have evidence that acupuncture is an acceptable and effective treatment for some symptoms such as pain and disorders such as insomnia and mood disorders. | Integr Cancer Ther. 2021 Jan-Dec;20:1534735420980811. doi: 10.1177/1534735420980811. | Insomnia Mood | Review |
| 33680223 | Therefore, acupuncture has a satisfactory therapeutic effect on diseases involving neuroendocrine pathological changes (such as chronic pain, menopause, depression, and insomnia), with a very rare occurrence of adverse events. | Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. | Insomnia Depression | Review |
| 33883931 | Scores from the European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Core 30 Item (EORTC-QLQ-C30) revealed that patients in the verum acupuncture group had slightly better scores in relieving pain, insomnia, and constipation than patients in the sham acupuncture arm, of which constipation was remarkably different between the two arms. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Insomnia | Review |
| 33917977 | The use of acupuncture has been investigated not only in various pain conditions but also in psychiatric problems such as depression, insomnia, and anxiety disorders. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Insomnia Anxiety Depression | Review |
| 33917977 | In these studies, the effects and/or underlying mechanisms of acupuncture on anxiety and fear behaviors, depression behavior, sleep disturbance, cognitive symptoms (especially spatial learning and memory), and stress responses in PTSD animal models have been reported (Figure 3 and Table 2). | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Insomnia Stress Response Learning and Memory Ability Anxiety Depression | Review |
| 33917977 | Although there is limited certainty, there is some evidence that acupuncture can improve sleep quality in patients with insomnia. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Insomnia Sleep Quality | Review |
| 33917977 | In a recent randomized controlled trial, acupuncture significantly decreased non-REMS stages 1 and 2, increased non-REMS stage 3, and improved episodic memory in patients with chronic insomnia disorder. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Insomnia | Review |
| 33986818 | Comparative Utility of Acupuncture and Western Medication in the Management of Perimenopausal Insomnia: A Systematic Review and Meta-Analysis | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Insomnia | Review |
| 33986818 | Many women with perimenopausal insomnia (PMI) have sought alternative therapies such as acupuncture because of concerns about risks associated with hormone replacement therapy (HRT) and/or psychotropic drugs. | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Insomnia | Review |
| 33986818 | For each study, the following data for demographic and clinical characteristics were extracted: the last name of the first author, publication year, grouping methods and number of patients in each group, duration of insomnia, diagnostic criteria used, TCM syndrome type of patients, protocols including timing, frequency and dosage in acupuncture, the acupoints selected, prescription in control group (type, dosage, and oral frequency of Western medication), outcome measures, results, follow-up, and adverse events. | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Insomnia | Review |
| 33986818 | Fifth, all the included psychotropic drugs are hypnotics, so it remains unclear if acupuncture is more effective and safer than other drugs such as Mirtazapine (antidepressant) and Quetiapine (antipsychotic drug) that are also widely used for insomnia in the clinical practice. | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Insomnia | Review |
| 33986818 | A previous systematic review also showed a substantial association of acupuncture with improved sleep disturbances in women with PMI or postmenopausal insomnia. | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Insomnia | Review |
| 33986818 | Furthermore, that review demonstrated that the association of reduction in menopause-related sleep disturbance and acupuncture was correlated with increase in serum E2 levels. | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Insomnia | Review |
| 34013776 | For the treatment of sleep disturbances following acquired brain injury, two studies included pharmacological therapy, six studies examined the effects of cognitive behavioral therapy and three studies investigated alternative interventions such as acupuncture. | Clin Rehabil. 2021 Nov;35(11):1518-1529. doi: 10.1177/02692155211014827. Epub 2021 May 20. | Insomnia | Review |
| 34122180 | AEs associated with acupuncture treatment were hematoma (16/146), feeling pain when inserting needle (4/154), dizziness (8/147), palpitation (4/83), dry mouth (1/41), nausea and/or vomiting (6/85), changes of character of stool (4/50), and sweating (5/44); AEs associated with standard (antidepressant or antidepressant combined with HRT) included fatigue (17/30), palpitation (25/206), headache (3/62), dizziness (40/472), sleep disturbance (25/250), sweating (10/30), dry mouth and/or halitosis (41/229), indigestion (1/32), loss of appetite (5/60), stomachache (18/105), nausea and/or vomiting (18/303), constipation (14/76), diarrhea (4/92), changes of character of stool (6/29), dysphoria (14/96), for excitation and agitation (2/30), akathisia (1/30), spasmus (1/60), breast distending pain (16/156), leukorrhagia (2/60), skin symptom (1/30), and elevated blood pressure (2/50). | Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. | Insomnia Nausea and Vomiting Blood Pressure | Review |
| 34122180 | To understand the relationship between PMD and insomnia as well as the comprehensiveness of acupuncture's effects, future studies need to include validated sleep measures such as Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), or actigraphy for sleep assessment in women with PMD. | Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. | Insomnia Sleep Quality | Review |
| 34122601 | Efficacy and Safety of Scalp Acupuncture for Insomnia: A Systematic Review and Meta-Analysis | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | To systematically evaluate the efficacy and safety of scalp acupuncture in the treatment of insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | CNKI, Wanfang database, CQVIP database, CBM, Web of Science, Cochrane Library, and PubMed were searched for the literature on the treatment of insomnia by scalp acupuncture from the establishment of the database to July 23, 2020. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | The effective rate of scalp acupuncture in the treatment of insomnia was significantly higher than that of the control group. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | Scalp acupuncture is effective and safe in the treatment of insomnia, which is worthy of clinical application. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | However, the efficacy and safety of scalp acupuncture in the treatment of insomnia has not been unified, and no one has conducted a systematic evaluation on it. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | This study aims to systematically evaluate the efficacy and safety of scalp acupuncture in the treatment of insomnia, so as to provide reference for clinical practice. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | The diagnostic criteria referred to the diagnostic criteria of chronic insomnia in the international classification of sleep disorders (3rd Edition); (3) the intervention measures in the treatment group were scalp acupuncture or head acupuncture alone for insomnia; (4) there was a clear treatment course; (5) the observation indexes were effective rate, PSQI score, and adverse events. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | The scalp acupuncture treatment of insomnia was significantly better than the control group in the occurrence of adverse events. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | The improvement of PSQI score by scalp acupuncture in the treatment of insomnia was still better than that of the control group, and the meta-analysis results were robust. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | Head acupuncture is more friendly to headache, insomnia, and other neurological diseases because of its unique role, with the rising number of insomnia cases, the side effects of sleeping pills are obvious, so scholars have a strong interest in acupuncture treatment of insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Side Effects Insomnia | Review |
| 34122601 | Current studies have found that scalp acupuncture can not only treat primary insomnia, but also treat insomnia caused by other diseases, such as perimenopausal insomnia and Parkinson's insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | At present, the mechanism of scalp acupuncture in the treatment of insomnia is still not conclusive, and modern basic research has carried out a lot of exploration. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | Some studies have found that scalp acupuncture can increase the concentration of cytokines IL-1 β, TNF-α, and IL-6 in the brain tissue of insomnia rats; some studies have found that scalp acupuncture may affect the secretion of neurotransmitters and regulate the central organs that affect sleep wakefulness; some studies have found that using scalp acupuncture to stimulate insomnia's areas of interest to varying degrees can promote the balance of physiological functions of the cerebral cortex and regulate the autonomic nervous system. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | With people's awareness of the side effects of drugs in the treatment of insomnia, there are more and more clinical studies on the treatment of insomnia with scalp acupuncture alone or in combination. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Side Effects Insomnia | Review |
| 34122601 | The systematic evaluation of the efficacy and safety of scalp acupuncture in the treatment of insomnia has great clinical significance. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | Through literature search, it is found that although there is a meta-analysis on the efficacy and safety of scalp acupuncture in the treatment of insomnia, the control group is mostly other forms of acupuncture or sham acupuncture. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | The comprehensive evaluation results show that scalp acupuncture is effective in treating insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | Compared with the control group, scalp acupuncture can significantly improve the effective rate of treating insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | Based on this study, we found that scalp acupuncture is effective and safe in the treatment of insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | According to the results of this study, scalp acupuncture is effective in the treatment of insomnia, and its efficacy and safety are better than those of drugs and blank treatments. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34122601 | It has the value of clinical promotion and application, but scalp acupuncture has no significant difference in efficacy and safety compared with other acupuncture treatments for insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Insomnia | Review |
| 34178633 | Moreover, patients treated with acupuncture were more likely to experience improvements in hot flashes scores, fatigue, sleep disturbance, and anxiety compared to those in the control group, while the improvements in depression were comparable across both groups. | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia Anxiety Depression | Review |
| 34178633 | Current evidence suggests that acupuncture might improve BC treatment-related symptoms measured with PROs including QoL, pain, fatigue, hot flashes, sleep disturbance and anxiety. | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia Anxiety | Review |
| 34178633 | The patients receiving acupuncture experienced less sleep disturbances compared with those in the control group (SMD -0.50, 95%CI, -0.71 to -0.28, P<0.00001, I2 = 0%) ( Figure 5A ). | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia | Review |
| 34178633 | At the EOT, the acupuncture group had a lower number of patients suffering from sleep disturbances than the control group (RR 0.51, 95%CI, 0.36 to 0.72, P=0.0001, I2 = 0%) ( Figure 5B ). | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia | Review |
| 34178633 | Forest plot of sleep disturbances in BC patients treated with acupuncture and control. | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia | Review |
| 34178633 | This review pointed out that the use of acupuncture might improve the QoL, pain, hot flashes, fatigue, sleep disturbance and anxiety of BC patients compared with the use of control management strategies, while the difference in depression was not statistically significant between the two groups at EOT. | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia Anxiety Depression | Review |
| 34178633 | The SIO clinical practice guidelines declared that there was not enough evidence for the application of acupuncture in managing sleep disturbances. | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia | Review |
| 34178633 | Acupuncture seemed to improve sleep disturbances compared to sham acupuncture based on the findings, but the limited number of rigorous studies prevented a convincing evidence from being obtained. | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia | Review |
| 34178633 | In a nutshell, acupuncture might improve BC treatment-related complications based on the measurements obtained from PROs including the QoL, pain, fatigue, hot flashes, sleep disturbance, and anxiety. | Front Oncol. 2021 Jun 10;11:646315. doi: 10.3389/fonc.2021.646315. eCollection 2021. | Insomnia Anxiety | Review |
| 34335848 | Not only is acupuncture effective for complications related to HD, such as uremic symptoms, insomnia, and fatigue, but also it is able to improve renal function, proteinuria, BP, anemia, and pain in CKD patients. | Evid Based Complement Alternat Med. 2021 Jul 13;2021:9953986. doi: 10.1155/2021/9953986. eCollection 2021. | Insomnia Blood Pressure Kidney | Review |
| 34397902 | Effectiveness and safety of acupuncture in treating sleep disturbance in dementia patients | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | This study aimed to comprehensively search and analyze randomized controlled clinical trials (RCTs) of acupuncture in treating sleep disturbance or sleep disorders in dementia patients | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | These studies reported clinical data suggesting that adjuvant acupuncture for hypnotics, and ear acupressure in dementia patients with sleep disorders or sleep disturbance may have clinical benefits in certain sleep-related parameters and total effective rate (TER). | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | Moreover, acupuncture is recognized as a promising therapeutic approach for insomnia. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | One of the greatest benefits of conducting acupuncture treatment for insomnia in patients with dementia could be that it does not require cognitive engagement. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | However, clinical evidence of acupuncture for the treatment of sleep disturbance in patients with dementia has not been systematically analyzed. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | Therefore, in this systematic review, we comprehensively searched and analyzed randomized controlled clinical trials (RCTs) of acupuncture in treating sleep disturbance or sleep disorders in dementia patients and discussed the clinical implications and suggestions for further studies. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | Original RCTs using acupuncture on sleep disturbance in dementia patients were included. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | The studies included in this review have reported clinical data suggesting that adjuvant acupuncture for hypnotics, and ear acupressure in dementia patients with sleep disorders or sleep disturbance, may have clinical benefits on some sleep-related parameters (i.e., PSQI and structured questionnaire) and TER. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | Given the small number of studies included and their small sample size and low methodological quality, this review could not draw definite conclusions about the effectiveness and safety of acupuncture or superiority of certain acupuncture treatment methods in dementia patients with sleep disturbance. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | This review explores the effectiveness and safety of acupuncture, a potentially promising non-pharmacological treatment strategy, in sleep disturbance, which is 1 of the important clinical challenges in dementia patients. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | No clinical study compared the effectiveness of acupuncture and CBT-I, which is initially recommended for the treatment of insomnia in the elderly. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | First, the number of acupuncture studies on sleep disorders or sleep disturbance in patients with dementia was insufficient. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | Considering that application of complementary and alternative medicine is common in elderly patients, further studies on acupuncture for sleep problems or sleep disturbance in patients with dementia need to be conducted. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | These studies should provide either a complementary/alternative role of acupuncture for CBT-I or medications that are currently being used to treat sleep problems and sleep disturbance in elderly or dementia patients, if possible. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | Since insomnia in dementia patients may be related to clinical aspects of dementia such as cognitive symptoms and BPSD, both direct effects of acupuncture for those outcomes and indirect effects mediated by sleep parameters should be considered in the analysis. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34397902 | This systematic review comprehensively searched and analyzed RCTs of acupuncture in treating sleep disturbance or sleep disorders in dementia patients. | Medicine (Baltimore). 2021 Aug 13;100(32):e26871. doi: 10.1097/MD.0000000000026871. | Insomnia | Review |
| 34489662 | This kind of experimental design is used to observe the changes in brain response after acupuncture treatment, which is helpful to explore the mechanism of long-term acupuncture effect such as investigating the effect of different courses of acupuncture and among different patients, and it is suitable for chronic diseases, such as insomnia (Wang et al.,) and depression (Wang et al.,). | Front Hum Neurosci. 2021 Aug 20;15:694919. doi: 10.3389/fnhum.2021.694919. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | In conclusion, acupuncture is a promising therapeutic strategy for comorbid depression and insomnia during perimenopause. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | This review aims to summarize and assess existing clinical and preclinical evidence of acupuncture as a treatment for perimenopausal insomnia and depression, as well as discuss the potential mechanisms involved. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | Effects and Safety of Acupuncture on Depression and Insomnia | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | As of September 2018, there were at least 34 SRs/MAs regarding acupuncture treatment for insomnia. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia | Review |
| 34675729 | In China, acupuncture has even been added as a routine remedy in the latest Guidelines for the Diagnosis and Treatment of Insomnia formulated by the Chinese Sleep Research Society (CSRS). | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia | Review |
| 34675729 | How is Acupuncture for Perimenopausal Depression and Insomnia Conceptualised in TCM | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | We expect that these summaries will help clinicians and policymakers judge the role of acupuncture, and its potential and feasibility for the management of depression and insomnia associated with perimenopause. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | All these studies reported that acupuncture reduced global scores of Pittsburgh Sleep Quality Index (PSQI)/Athens Insomnia Scale (AIS) more effectively than hypnotics, except for two trials that reported the sleep-promoting effects between the two therapies were equivalent. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Sleep Quality | Review |
| 34675729 | Many RCTs have missing components in their methodology, which dilutes and weakens the quality of evidence, and may hinder the development of acupuncture as a form of evidence-based healthcare for comorbid depression and insomnia during perimenopause. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | Potential mechanisms by which acupuncture may improve perimenopausal depression and insomnia. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | Acupuncture may also improve perimenopausal depression and insomnia by improving vasomotor symptoms, while this indirect effect is not shown. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | It is challenging to explore the mechanisms underlying the effects of acupuncture on depression and insomnia during the transition to menopause in only RCTs. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34675729 | Xi et al reported significant symptom-relief in chronic insomniacs who underwent acupuncture, accompanied by downregulation in serum CRH, ACTH and CORT expression. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia | Review |
| 34675729 | According to the domino theory mentioned in the previous section, the improvement of insomnia caused by acupuncture may also be one of the mechanisms of PMD remission, and vice versa. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia | Review |
| 34675729 | Despite some methodological deficiencies, acupuncture could be an adjunct therapy or viable and safe option for women with comorbid depression and insomnia during perimenopause. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Insomnia Depression | Review |
| 34721179 | Acupuncture for depression-related insomnia may be an alternative to drug therapy (Dong et al.,). | Front Psychol. 2021 Oct 13;12:721872. doi: 10.3389/fpsyg.2021.721872. eCollection 2021. | Insomnia Depression | Review |
| 34729102 | Meanwhile, as the non-pharmacologic approaches, acupuncture and EA have been shown to be effective for treating primary insomnia, insomnia after stroke, menopause insomnia, and chronic pain-related insomnia, but whether they are effective to treat CRI remains controversial. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Insomnia | Review |
| 34729102 | Acupuncture and EA have been shown to improve insomnia by reducing the sympathetic nervous activity, suppressing the activation of the hypothalamic-pituitary-adrenal (HPA) axis, increasing the levels of Gamma-aminobutyric acid (GABA) and GABA(A) receptor, and elevating the generation and secretion of melatonin. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Insomnia | Review |
| 34729102 | This review summarized the application of acupuncture and EA in cancer patients for improving cancer-related symptoms and side-effects, such as fatigue, insomnia, chemotherapy-associated dyspepsia syndrome (CADS), radiation-induced xerostomia (RIX), anxiety and depression, and pain (Table 1). | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects Insomnia Anxiety Depression | Review |
| 34795484 | The Role of Acupuncture in Treating Perimenopausal Insomnia: An Overview and Quality Assessment of Systematic Reviews and Meta-Analyses | Neuropsychiatr Dis Treat. 2021 Nov 11;17:3325-3343. doi: 10.2147/NDT.S337504. eCollection 2021. | Insomnia | Review |
| 34795484 | To summarize and critically assess the reliability of the methodological quality and outcome measures from systematic reviews (SRs)/meta-analyses (MAs) and provide an overall verdict about the therapeutic value of acupuncture for perimenopausal insomnia (PMI). | Neuropsychiatr Dis Treat. 2021 Nov 11;17:3325-3343. doi: 10.2147/NDT.S337504. eCollection 2021. | Insomnia | Review |
| 34795484 | Originating from ancient China, acupuncture, is one of the most popular forms of CAM with simple maneuverability and a high degree of safety, and historically it has been utilized for insomnia and other mental illness in East Asian countries (eg, China, Korea, Japan, etc.). | Neuropsychiatr Dis Treat. 2021 Nov 11;17:3325-3343. doi: 10.2147/NDT.S337504. eCollection 2021. | Insomnia | Review |
| 34795484 | Worsening of insomnia was the only AE for placebo-acupuncture. | Neuropsychiatr Dis Treat. 2021 Nov 11;17:3325-3343. doi: 10.2147/NDT.S337504. eCollection 2021. | Insomnia | Review |
| 34868943 | However, in psychosomatic symptoms such as anxiety, sleep disturbance, and fatigue, acupuncture and exercise training did not result in significant improvements. | Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. | Insomnia Anxiety | Review |
| 34868943 | The effect of acupuncture on anxiety and sleep disturbance was performed in a meta-analysis by using HADS-A and PSQI. | Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. | Insomnia Anxiety | Review |
| 34868943 | The evidence suggests that both acupuncture and exercise result in little to no change in anxiety, sleep disturbance, and fatigue in patients suffering from psychosomatic symptoms, but the quality of the evidence for this outcome was not high, either. | Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. | Insomnia Anxiety | Review |
| 34868943 | However, acupuncture or exercise training could not significantly improve some psychosomatic symptoms (such as anxiety, sleep disturbance, and fatigue). | Front Oncol. 2021 Nov 12;11:745280. doi: 10.3389/fonc.2021.745280. eCollection 2021. | Insomnia Anxiety | Review |
| 34983587 | Acupuncture can be effective in the management of not only pain, but also symptoms such as insomnia, anxiety, and joint pain. | Chin Med. 2022 Jan 5;17(1):8. doi: 10.1186/s13020-021-00558-4. | Insomnia Anxiety | Review |
| 35036916 | The safety and efficacy of using moxibustion and or acupuncture for cancer-related insomnia: a systematic review and meta-analysis of randomised controlled trials | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Insomnia | Review |
| 35036916 | This study aimed to synthesise the best available evidence on the safety and efficacy of using moxibustion and/or acupuncture to manage cancer-related insomnia (CRI). | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Insomnia | Review |
| 35036916 | We synthesised the best available evidence on the safety and efficacy of using moxibustion and/or acupuncture to manage cancer-related insomnia (CRI). | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Insomnia | Review |
| 35036916 | Flowchart of literature selection on randomised controlled trials of acupuncture for the management of cancer-related insomnia. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Insomnia | Review |
| 35036916 | Efficacy of moxibustion and or acupuncture for the management of cancer-related insomnia: outcomes measured as continuous data. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Insomnia | Review |
| 35036916 | Efficacy of moxibustion and or acupuncture for the management of cancer-related insomnia: outcomes measured as dichotomous data. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Insomnia | Review |
| 35036916 | This study suggested that the effect of using moxibustion and acupuncture to treat tumour patients with insomnia is as good as conventional medicine, but its long-term effect is better with no side effects. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Side Effects Insomnia | Review |
| 35036916 | The authors concluded that acupuncture significantly relieves sleep disturbances and is a good and safe treatment in managing CRI. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Insomnia | Review |
| 35168522 | Although acupuncture has been used to manage various physical symptoms that may present as side effects from antidepressants, including nausea, insomnia, weight gain, and sexual dysfunction, few studies have directly demonstrated that acupuncture could improve the side effects of antidepressants. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects Insomnia Nausea and Vomiting | Review |
| 35281899 | Accumulating evidences indicate that acupuncture is safe and has great clinical efficacy in the treatment of various diseases, including gastrointestinal diseases, neurodegenerative diseases, cardiovascular diseases, chronic pain, insomnia and CKD. | Front Pharmacol. 2022 Feb 25;13:816025. doi: 10.3389/fphar.2022.816025. eCollection 2022. | Cardiovascular Insomnia | Review |
| 35345621 | Efficacy and Safety of Acupuncture in the Treatment of Poststroke Insomnia: A Systematic Review and Meta-Analysis of Twenty-Six Randomized Controlled Trials | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | To evaluate the efficacy and safety of acupuncture in the treatment of poststroke insomnia. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | PubMed, the Cochrane Library, Embase, Web of Science, China Biology Medicine (CBM), CNKI, VIP, and Wanfang databases were searched by computer from their inception to April 29, 2021, for collecting all randomized controlled trials of acupuncture in the treatment of poststroke insomnia. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | Acupuncture alone or acupuncture combined with oral drugs is more effective and safer than oral drugs alone in the treatment of poststroke insomnia, which is suitable to promote in clinical practice. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | The existing clinical trials have shown that acupuncture has more advantages than western medicine, with rapid effects, safety, and convenience and no obvious adverse reactions, which is more and more favored by insomnia patients and has become one of the effective ways to treat insomnia. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Adverse Reactions Insomnia | Review |
| 35345621 | At present, there are many clinical trials of acupuncture in the treatment of poststroke insomnia, but the interventions adopted have many forms and the quality of literature is uneven, which hinders the clinical promotion of acupuncture in patients with poststroke insomnia to a certain degree. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | Hence, our study collected the clinical trials of acupuncture in the treatment of poststroke insomnia for meta-analysis and compared the efficacy and safety of acupuncture against poststroke insomnia to provide a reliable evidence-based basis for the clinical application of acupuncture in patients with poststroke insomnia. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | All randomized controlled trials (RCTs) of acupuncture in the treatment of poststroke insomnia were eligible, regardless of blinding, publication status, or region, but the language was restricted to Chinese and English. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | The retrieval method employed the combination of Medical Subject Headings (MeSH) terms and free terms, involving acupuncture, acupuncture and moxibustion, electroacupuncture, apoplexy, stroke, cerebral infarction, insomnia, acupuncture therapy, poststroke insomnia, cerebrovascular accident, sleeplessness, and so forth. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, China Biology Medicine (CBM), PubMed, Cochrane Library, Embase, and Web of Science were searched from the establishment of the databases to April 29, 2021, to collect all the randomized controlled trials of acupuncture in the treatment of poststroke insomnia. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | In this study, the funnel plot was used to evaluate whether there was potential publication bias in the included literature, and 24 studies recording the effective rate of acupuncture in the treatment of poststroke insomnia were tested. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | Previous studies have shown that acupuncture can improve the sleep quality of poststroke insomnia patients. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia Sleep Quality | Review |
| 35345621 | Acupuncture has a unique effect on the treatment of poststroke insomnia, which adjusts the function of internal organs and increases the patient's sleep duration and sleep efficiency by stimulating specific acupoints on the patient's body. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | In conclusion, acupuncture is indeed effective in the treatment of poststroke insomnia based on the research results. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35345621 | It is expected that more large-sample and high-quality clinical RCTs will be carried out to provide more reliable lines of evidence for acupuncture in the treatment of poststroke insomnia. | Evid Based Complement Alternat Med. 2022 Mar 19;2022:5188311. doi: 10.1155/2022/5188311. eCollection 2022. | Insomnia | Review |
| 35481320 | studied breast cancer patients undergoing reconstructive surgery who were evaluated post operatively using visual analog scores (VAS) to determine pain, mood, energy, relaxation, insomnia, stress, anxiety, alertness, fatigue, and tension after massage alone or with the addition of acupuncture. | Cureus. 2022 Mar 24;14(3):e23443. doi: 10.7759/cureus.23443. eCollection 2022 Mar. | Insomnia Anxiety Mood | Review |
| 35492706 | The Role of Acupuncture in the Management of Insomnia as a Major or Residual Symptom Among Patients With Active or Previous Depression: A Systematic Review and Meta-Analysis | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Due to concerns about risks associated with antidepressants and/or hypnotics, complementary therapies such as acupuncture have been sought by patients with active or previous depression to manage insomnia. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | This systematic review aimed to clarify if acupuncture is effective and safe enough to be recommended as an alternative or adjuvant therapy to standard care in ameliorating concomitant or residual insomnia, two types of insomnia associated with depression. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Randomized controlled trials (RCTs) of depression-related insomnia (DI) treatment via acupuncture vs. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | For insomnia as a major symptom of active depression, meta-analyses suggested that acupuncture significantly reduced the global scores of both the Pittsburg Sleep Quality Index (PSQI) [MD = â3.12, 95% CI (â5.16, â1.08), p < 0.01] and Hamilton Depression Scale (HAMD) [SMD = â2.67, 95% CI (â3.51, â1.84), p < 0.01], in comparison with placebo-acupuncture. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression Sleep Quality | Review |
| 35492706 | For insomnia as a residual symptom of previous or partially remitted depression, acupuncture conferred a very limited, non-significant therapeutic advantage against sham-/placebo-acupuncture. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Whether acupuncture has an add-on effect to conventional pharmacotherapy in this type of insomnia has not been investigated. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia | Review |
| 35492706 | There is a low to moderate level of evidence supporting acupuncture as a safe and effective remedy alternative to or adjuvant to conventional pharmacotherapy (antidepressant and/or hypnotic) in improving insomnia and other depression symptoms among patients with active depression. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | The benefit of acupuncture on residual insomnia associated with previous or partially remitted depression is limited. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | The search was carried out by combining search terms from four categories: (1) acupuncture, (2) depression, (3) insomnia, and (4) RCT. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | A predetermined data form was employed to extract the following information (demographic and clinical characteristics) from each study: identification information, publication year, types of DI (insomnia as a major symptom or a residual symptom of depression), grouping methods as well as number and gender of participants in each group, duration of DI, diagnostic criteria employed, TCM syndrome pattern of DI included, intervention protocols including acupuncture frequency, session and duration as well as acupoint selection, prescription in comparator (frequency, session, and duration in placebo-/sham-acupuncture; or type, dosage, and oral frequency of Western medication; or regimen of CBT-i), outcome measures, results, follow-up duration and results, and adverse events (AEs). | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Of the 21 trials, two trials investigated the efficacy of acupuncture for depression-associated residual insomnia using a three-arm design with both placebo-acupuncture and sham-acupuncture as controls. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | The remaining 19 trials investigated the efficacy of acupuncture for active depression accompanying or comorbid with insomnia. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | In the first category (the therapeutic effect of acupuncture on insomnia as a major symptom of active depression), we further split the analyses into three sections: (1) acupuncture vs. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | In the second category (the therapeutic effect of acupuncture on insomnia as a residual symptom of previous or partially remitted depression), we only qualitatively described the results because there were not enough RCTs (n < 3) to conduct meta-analysis (Appendix 7). | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Effect of Acupuncture on Insomnia as a Major Symptom of Active Depression | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | No significant differences were identified between acupuncture and antidepressant (paroxetine, sertraline, or citalopram) in improving subjective sleep quality [MD = â0.01, 95% CI (â0.23, 0.21), p = 0.94], shortening sleep latency [MD = 0.05, 95% CI (â0.15, 0.25), p = 0.64], increasing sleep duration [MD = 0.01, 95% CI (â0.24, 0.25), p = 0.95] and habitual sleep efficiency [MD = â0.14, 95% CI (â0.42, 0.13), p = 0.31], and ameliorating sleep disturbances [MD = 0.03, 95% CI (â0.16, 0.22), p = 0.72] and daytime dysfunction [MD = 0.13, 95% CI (â0.11, 0.38), p = 0.29; Figure 4. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Sleep Quality | Review |
| 35492706 | Effect of Acupuncture on Insomnia as a Residual Symptom of Previous or Partially Remitted Depression | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | sham-EA) from the same research team (Hong Kong, China) investigated the efficacy and safety of acupuncture on residual insomnia after remission or partial response of a major depressive disorder. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia | Review |
| 35492706 | Among patients with insomnia as a major symptom in active depression (that is, depression accompanying/comorbid with insomnia), acupuncture appeared to be superior to either placebo-acupuncture or antidepressants and/or hypnotics in improving both poor sleep and depressive symptoms. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | In the treatment of patients with insomnia as a residual symptom in previous or partially remitted depression, acupuncture appeared to only possess marginally better efficacy than placebo-acupuncture and had no superior efficacy to sham-acupuncture, indicating that the observed differences between verum- and placebo-acupuncture might be due to non-specific effects of needling. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | To the best of our current knowledge, this is the first systematic review and meta-analysis comprehensively investigating the collective evidence regarding the efficacy of acupuncture as an alternative or adjuvant management to standard care in the management of insomnia as a major or residual symptom among patients with active or previous/partially remitted depression. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | In addition to the stricter selection criteria and usage of widely accepted analysis tools as mentioned above, the merits of our current review also included the following: (1) considering the distinct clinical characteristics between two types of DI, the therapeutic effect of acupuncture on them was separately analyzed and different conclusions were drawn; (2) with limited data synthesis (derived from three RCTs), we were the first to report the significant efficacy differences between verum- and placebo-acupuncture on insomnia as a major symptom among patients with depression; (3) the STRICTA checklist and the GRADE system were introduced to appraise the reporting quality and evidence quality, respectively; and (4) we provided a complete list of excluded studies with justification for the exclusion of each, so as to present a transparent and comprehensive screening process and enable readers to determine whether there is a risk of unjustified exclusion. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Since ancient times, acupuncture has been used to treat insomnia and/or depression. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | In the past decade, at least 31 systematic reviews and at least 34 systematic reviews investigating the treatment of depression and insomnia, respectively, with acupuncture, have been published, reflecting the continuous growth of attention and research interest in the management of psychological and sleep disorders by using acupuncture in the international medical community. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Nevertheless, there was no significant difference between acupuncture with low-frequency treatment sessions (<5 sessions per week) and standard care in improving both insomnia and depression symptoms among patients. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | On the basis of these findings, we here recommend that, when delivering acupuncture treatment for patients with active depression and concomitant insomnia, clinical practitioners may consider increasing the frequency of acupuncture treatment, such as providing five treatment sessions per week, to enhance the hypnotic effect of acupuncture. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Although the search was comprehensive, only two trials from the same research team concerning acupuncture for depression-associated residual insomnia were identified. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | We cannot deny the placebo effect of acupuncture; indeed, in the management of insomnia, positive beliefs, anticipation, and expectations concerning CAM may result in more favorable outcomes and higher satisfaction with CAM, i.e., the placebo effect. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia | Review |
| 35492706 | Therefore, other potentially effective therapies (including combined application of acupuncture and hypnotic/antidepressant/CBT-i/repetitive transcranial magnetic stimulation) also need to be actively sought and determined; after all, the available evidence does not, in any case, support the use of acupuncture alone in managing residual insomnia associated with previous or partially remitted depression. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Coincidentally, in a previous systematic review summarizing herb/acupuncture prescriptions for insomnia, these three acupoints were also identified to be frequently used but were non-specific for TCM patterns. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia | Review |
| 35492706 | Since acupuncture has not been proven to be effective for residual insomnia associated with previous or partially remitted depression, we do not recommend any acupoints for this type of insomnia. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | One trial in the current review reported significant improvements in both insomnia and depressive symptoms among patients with DI after receiving acupuncture treatment, accompanied by increased serum NPY and decreased SP levels, and these positive changes were not identified in the placebo-acupuncture group. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia | Review |
| 35492706 | This review has provided a low to moderate level of evidence supporting acupuncture as a safe and effective remedy alternative to or adjuvant to conventional pharmacotherapy (antidepressant and/or hypnotic) in improving insomnia as a major symptom among patients with active depression as well as their depressed mood. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression Mood | Review |
| 35492706 | The effect of acupuncture on residual insomnia associated with previous or partially remitted depression requires further research employing optimal dosage of treatment. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression | Review |
| 35492706 | Searching for other potentially positive therapeutic strategies, including acupuncture combined with standard care (antidepressant and/or hypnotic, and/or CBT-i) in managing this type of insomnia, also remains warranted and urgent. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia | Review |
| 35586692 | The regulation of ED using acupuncture has the following objectives: to alleviate the local symptoms of the patients, such as erectile weakness and difficulty in maintaining an erection, to address the overall contributing symptoms, such as fatigue, insomnia, low appetite, and constipation, to identify the syndrome type in the patients according to tongue diagnosis and pulse diagnosis, and to select suitable acupoints for treatment. | Evid Based Complement Alternat Med. 2022 May 9;2022:4807271. doi: 10.1155/2022/4807271. eCollection 2022. | Heart Rate Insomnia | Review |
| 35619992 | SUI can severely impair a patient's ability to perform daily activities, leading to embarrassment, insomnia, and social isolation, and acupuncture is a minimally invasive technique with the potential treatment of SUI. | Pain Res Manag. 2022 May 17;2022:5887862. doi: 10.1155/2022/5887862. eCollection 2022. | Insomnia | Review |
| 35664757 | Association of Acupuncture and Auricular Acupressure With the Improvement of Sleep Disturbances in Cancer Survivors: A Systematic Review and Meta-Analysis | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | Studies on the efficacy of acupuncture and auricular acupressure on sleep disturbances in cancer patients have been growing, but there is no specific and comprehensive systematic review and meta-analysis. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | This review aims to evaluate the efficacy and safety of acupuncture and auricular acupressure on sleep disturbances in cancer survivors based on existing randomized clinical trials (RCTs). | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | Subgroup analyses suggested no evidence that auricular acupressure (MD, 3.14; 95% CI=1.52, 4.76; p = 0.0001; I2 = 0%) or acupuncture (MD, 0.54; 95% CI=â1.27, 2.34; p = 0.56; I2 = 0%) was associated with the reduction in insomnia scale scores. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | This systematic review and meta-analysis found no evidence about acupuncture or auricular acupressure in the improvement of sleep disturbances in cancer survivors in terms of short- or long-term effect. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | The finding was inconsistent with previous research and suggested that more well-designed and large-scale randomized controlled trials are needed to identify the efficacy of acupuncture and auricular acupressure for sleep disturbances in cancer survivors. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | Both acupuncture and auricular acupressure (AA), as complementary and alternative treatment, might be promising treatment options, which appear to be effective in improving cancer-related insomnia. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | Studies on acupuncture and AA for cancer-related insomnia have been growing. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | There were two systematic reviews discussing the association of acupuncture with cancer-related insomnia. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | Interventions included acupuncture and/or AA regardless of specific needling techniques such as manual acupuncture, electroacupuncture, or a combination of acupuncture or AA with other therapies for sleep disturbances. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | The search terms included (acupuncture OR acupuncture therapy OR auricular acupressure) AND (cancer OR tumor OR neoplasms OR carcinoma OR malignancy) AND (sleep initiating and maintaining disorders, insomnia OR sleep disturbance OR sleep disorder OR wakefulness OR waking) AND (randomized controlled trial OR controlled clinical trial) in Chinese and English. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | Two sham-controlled RCTs showed no significance of acupuncture or AA on insomnia scale scores (MD, 1.71; 95% CI=â2.38, 5.81; p = 0.41; I2 = 89%; Figure 3D ). | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | When compared to sham control, subgroup analyses suggested no evidence that AA (MD, 3.14; 95% CI=1.52, 4.76; p = 0.0001; I2 = 0%) and acupuncture (MD, 0.54; 95% CI=-1.27, 2.34; p = 0.56; I2 = 0%) were associated with the reduction in insomnia scale scores. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | Forest plots of the (A) short-term effect and (B) long-term effect of acupuncture or auricular acupressure for cancer-related insomnia. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | This is the first review and meta-analysis to investigate the efficacy and safety of acupuncture and AA in sleep disturbances of cancer survivors. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | In reality, psychological effect was inevitable in the course of sham acupuncture for insomnia in cancer patients, while psychology was strongly linked with insomnia disorder. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | In short, future RCTs are needed to provide robust evidence of the association of acupuncture or AA with the improvement of sleep disturbances of cancer survivors. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | The findings of this systematic review and meta-analysis suggest that acupuncture or AA is irrelevant to the improvement of sleep disturbances in cancer survivors for short- or long-term effects. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35664757 | To further understand the potential role of acupuncture and AA on cancer-related insomnia, well-designed and large-scale randomized controlled trials are needed. | Front Oncol. 2022 May 18;12:856093. doi: 10.3389/fonc.2022.856093. eCollection 2022. | Insomnia | Review |
| 35725779 | Clinical studies show that acupuncture can reduce some of the common symptoms experienced by cancer patients such as nausea and vomiting, pain, fatigue, insomnia, etc. | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Insomnia Nausea and Vomiting | Review |
| 35725779 | A few studies investigated the effect of acupuncture on insomnia in cancer patients. | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Insomnia | Review |
| 35725779 | In a systematic review by Choi et al., six low to moderate bias RCTs (with a total of 475 patients) studying the effect of acupuncture on cancer related insomnia compared to other interventions were included. | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Insomnia | Review |
| 35725779 | In the two RCTs studying the effect of acupuncture on cancer-related insomnia when compared to sham acupuncture, one RCT showed beneficial effects, while the other trial did not. | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Insomnia | Review |
| 35782438 | The benefits of Chinese herbal medicine (CHM) and acupuncture therapies for post-stroke insomnia have been widely reported in RCTs (81.60% and 75.38%, respectively). | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | For better evidence translation, clinical trials on specific CHM interventions and high-quality systematic reviews on acupuncture for post-stroke insomnia should be conducted. | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | Accumulated evidence has suggested that traditional and complementary therapies improved sleep, such as Chinese herbal medicine (CHM), acupuncture and Taichi for insomnia, acupuncture for sleep-related breathing disorders (SBDs), and acupuncture for restless leg syndrome (RLS). | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | Most SRs were related to post-stroke insomnia (n = 15, 71.43%), including one treated with CHM, 13 with acupuncture therapies, one with massage. | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | Of the RCTs on insomnia, acupuncture therapies (n = 196, 46.34%) were investigated most frequently, such as needling acupuncture and electro-acupuncture (n = 107, n = 54.59%), auricular acupressure (n = 19, 9.69%), acupoint moxibustion (n = 9, 4.59%), and integration of multiple acupuncture therapies (n = 42, 21.43%). | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | Of the 74 non-RCTs, post-stroke insomnia continuously ranked at the top (n = 46, 62.16%), including 19 non-RCTs for combination therapies (41.30%), 13 for CHM (28.26%), and 14 for acupuncture therapies (30.43%), followed by unspecified sleep disorders (n = 26, 35.14%), and SBD (n = 1, 1.35%), which were treated with acupuncture therapies and sleep-wake disorders (n = 1, 1.35%). | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | Regarding the types of treatments, CHM was assessed most frequently in observational studies for post-stroke insomnia (n = 18, 41.86%), followed by acupuncture therapies (n = 18, 41.86%), combination therapies (n = 6, 13.95%), and other therapies, such as TCM exercise (n = 1, 2.33%). | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | For post-stroke insomnia, most studies suggested that TCM performed potentially better than the control; however, a considerable number of RCTs on acupuncture therapies reported mixed results (n = 39). | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | The major clinical evidence was the effectiveness assessment for CHM and acupuncture, and post-stroke insomnia was the type of participants in most studies. | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | Although the number of SRs on acupuncture for post-stroke insomnia was large, their quality was significantly low to reach a certain conclusion. | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | In addition, we identified seven protocols of SRs and one protocol for RCT, most of which were assessing acupuncture therapies for post-stroke insomnia, and results of them were not published. | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35782438 | Prioritizing high-quality clinical trials on specific CHM interventions and improving the quality of SRs on acupuncture for a better evidence translation to clinical practice of post-stroke insomnia | Front Psychiatry. 2022 Jun 15;13:865630. doi: 10.3389/fpsyt.2022.865630. eCollection 2022. | Insomnia | Review |
| 35978992 | These meta-analyses show that acupuncture treatment effectively affects global health status, physical functioning, pain, emotional, insomnia, and social functioning. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Insomnia Mood | Review |
| 35978992 | The results showed that acupuncture could improve CIBP patients' global health status, physical functioning, pain, emotional, insomnia, social functioning, and KPS scores. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Insomnia Mood | Review |
| 36011540 | MEDLINE, PubMed, SCOPUS and Web of Science databases were systematically searched for randomized controlled trial studies evaluating efficacy data of dry needling or/and acupuncture treatments to improve pain, fatigue, sleep disturbance and impaired quality of life and/or daily function. | Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. | Insomnia | Review |
| 36011540 | Acupuncture and dry needling therapies seems to be effective in patients with FM, since both reduced pain pressure thresholds, anxiety, depression, fatigue, sleep disturbances and disability in the short term. | Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. doi: 10.3390/ijerph19169904. | Insomnia Anxiety Depression | Review |
| 36119472 | Acupuncture also alleviates side effects induced by chemotherapy or radiotherapy such as nausea and vomiting, cancer-related pain, fatigue, insomnia, and the QOL. | Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. | Side Effects Insomnia Nausea and Vomiting | Review |
| 36119472 | Forest plot of the sleep disturbances measured by Pittsburgh Sleep Quality Index in lung cancer patients treated with acupuncture and control. | Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. | Insomnia Sleep Quality | Review |
| 36148057 | Recently, bibliometric analyses of acupuncture and obstetrical and gynecological diseases, migraine, insomnia, knee osteoarthritis, and cancer have been reported, revealing the research progress and frontiers of acupuncture and related diseases. | Front Cardiovasc Med. 2022 Sep 6;9:920491. doi: 10.3389/fcvm.2022.920491. eCollection 2022. | Insomnia | Review |
| 36148057 | In the past, for a long time, acupuncture was used to treat neurological diseases (including hemiplegic paralysis, facial paralysis, insomnia, and cephalalgia), orthopedic diseases (such as protrusion of the lumbar intervertebral disc, cervical spondylosis, and knee osteoarthritis), and gastrointestinal diseases (such as constipation, diarrhea, and hiccup singulation); cardiovascular diseases were not included in the spectrum of common ailments treated by acupuncture. | Front Cardiovasc Med. 2022 Sep 6;9:920491. doi: 10.3389/fcvm.2022.920491. eCollection 2022. | Cardiovascular Insomnia | Review |
| 36176875 | Regardless of systematic reviews, and randomized controlled trials on CAM, acupuncture, acupressure, herbal medicine, yoga, and tai chi, for insomnia, most of the RCTs did not agree with the findings. | Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. eCollection 2022 Aug. | Insomnia | Review |
| 36176875 | Common CAM therapies for insomnia include herbal and nutritional medicine, acupuncture, acupressure, yoga, tai chi, and mind-body practices. | Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. eCollection 2022 Aug. | Insomnia | Review |
| 36176875 | Although few systematic reviews have been conducted on the use of acupuncture and valerian in treating insomnia, but comprehensive study on all primary CAM treatments has not been conducted. | Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. eCollection 2022 Aug. | Insomnia | Review |
| 36176875 | The PubMed search strategy was : (((((((((((INSOMNIA) OR (insomnia[MeSH Terms])) AND (complementary medicine[MeSH Terms])) OR (alternative medicine[MeSH Terms]))) OR (complementary and alternative medicine[MeSH Terms]))) OR Natural practices OR Manual practices OR Mind-body intervention practices OR Acupuncture OR Acupressure OR Yoga OR Tai Chi AND (The Pittsburgh Sleep Quality Index[MeSH Terms])) OR (PSQI[MeSH Terms])) OR (sleep quality[MeSH Terms])) OR (sleep latency[MeSH Terms])) OR (adjustment sleep disorder[MeSH Terms]) ((((""insomnia s""[All Fields] OR ""sleep initiation and maintenance disorders""[MeSH Terms] OR (""sleep""[All Fields] AND ""initiation""[All Fields] AND ""maintenance""[All Fields] AND ""disorders""[All Fields]) OR ""sleep initiation and maintenance disorders""[All Fields] OR ""insomnia""[All Fields] OR ""insomnias""[All Fields] OR ""sleep initiation and maintenance disorders""[MeSH Terms]) AND ""complementary therapies""[MeSH Terms]) OR ""complementary therapies""[MeSH Terms] OR ((""complementaries""[All Fields] OR ""complementary""[All Fields]) AND ""complementary therapies""[MeSH Terms])) AND ((""Pittsburgh""[All Fields] AND (""sleep quality""[MeSH Terms] OR (""sleep""[All Fields] AND ""quality""[All Fields]) OR ""sleep quality""[All Fields])) AND OR ""sleep quality""[MeSH Terms] OR ""sleep latency""[MeSH Terms] OR ""dyssomnias""[MeSH Terms | Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. eCollection 2022 Aug. | Insomnia Sleep Quality | Review |
| 36176875 | Acupuncture and acupressure seem to contribute to treating insomnia, probably by the neurochemical modulatory activity of serotonin, dopamine, and endogenous opioids. | Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. eCollection 2022 Aug. | Insomnia | Review |
| 36176875 | revealed that definitive conclusions could not be derived on acupuncture's efficacy for insomnia. | Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. eCollection 2022 Aug. | Insomnia | Review |
| 36176875 | However, clinically relevant conclusions cannot be drawn because of clinical heterogeneity and methodological limitations. Regarding CAM treatments for insomnia, it demonstrates evidence in support of acupressure, yoga, and tai chi; mixed evidence for the use of acupuncture and L-tryptophan; and insufficient evidence for the practice of natural medicines such as valerian. | Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. eCollection 2022 Aug. | Insomnia | Review |
| 36186098 | Effectiveness of Acupuncture, Mind and Body Practices, and Natural Products for Insomnia: an overview of systematic reviews | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | The CAMs frequently used for insomnia symptoms include acupuncture, moxibustion, tai chi, yoga, Tui Na, and herbal medicine. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | Among 30 SRs/MAs, 19 SRs/MAs reported the effects of acupuncture on the PSQI based on insomnia. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | As a result, acupuncture was reported to be effective for insomnia except for some SRs/MAs using electroacupuncture and needle-rolling acupuncture. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | In 13 out of 19 SRs/MAs, PSQI was reported by comparing the effects of acupuncture to western medicines for insomnia. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | In 13 out of 19 SRs/MAs, PSQI was reported by comparing the effect of acupuncture to sham/placebo acupuncture for insomnia. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | Three out of 19 SRs/MAs compared acupuncture with no treatment for insomnia, and all reported that acupuncture was effective. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | The results of this overview confirmed the positive effects of acupuncture, MBP, and natural products as measured by PSQI on insomnia. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36186098 | PSQI was used to confirm the positive effects of acupuncture, MBP, and natural products on insomnia. | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Insomnia | Review |
| 36268156 | There was not a significant change in PSQI score (Pittsburgh sleep quality index) between patients and controls after 4 weeks of acupuncture therapy, according to a paper written by Wang et al.. The study was conducted on patients with insomnia. | Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. | Insomnia Sleep Quality | Review |
| 36268156 | The PSQI score of insomnia patients following acupuncture therapy was substantially different from that of the control group, according to a controlled clinical investigation that was conducted by Yin et al.. The study was conducted in a hospital setting. | Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. | Insomnia | Review |
| 36268156 | TCM characteristic therapy has been gradually paid attention and widely used in the treatment of insomnia, especially the traditional external treatment of TCM such as acupuncture and massage developed on the basis of the theory of meridians and viscera in TCM, which has the advantages of good clinical efficacy and less adverse reactions. | Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. | Adverse Reactions Insomnia | Review |
| 36268156 | Acupuncture can regulate viscera in the treatment of insomnia and has the advantages of safety and no side effects. | Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. | Side Effects Insomnia | Review |
| 36268156 | Massage is also commonly used in the treatment of insomnia, manipulation mostly acts on the head of the human body, healers often massage with acupuncture, so that the effect is significantly and lasting. | Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. | Insomnia | Review |
| 36532179 | And the remaining eight cases had adverse effects such as subcutaneous bleeding, acupuncture pain, and insomnia. | Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. | Adverse Reactions Insomnia Bleeding | Review |
| 36532179 | The adverse events in experimental groups included subcutaneous hemorrhage, pain or numbness from acupuncture, rapid heartbeat, dizziness, diarrhea, nausea, insomnia, and fainting from acupuncture. | Front Psychiatry. 2022 Dec 1;13:1051324. doi: 10.3389/fpsyt.2022.1051324. eCollection 2022. | Insomnia Bleeding Nausea and Vomiting | Review |
| 36570846 | It was found that acupuncture effectively alleviates ANS dysfunction-associated symptoms in its indications, such as migraine, depression, insomnia, functional dyspepsia, functional constipation. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Insomnia Depression | Review |
| 36570846 | Various lines of evidence have shown that acupuncture alleviates diseases and symptoms accompanied by autonomic disorders, such as migraine, depression, insomnia, functional dyspepsia, and constipation. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Insomnia Depression | Review |
| 36570846 | According to a 2018 US survey, acupuncture is widely used to treat its indications of which the top 10 are lower back pain (LBP), depression, anxiety, headache, arthritis, allergy, systemic pain, female infertility, insomnia, and shoulder and neck pain, with pain ranking first among them. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Insomnia Anxiety Depression | Review |
| 36590284 | The clinical efficacy and safety of acupuncture intervention on cancer-related insomnia: A systematic review and meta-analysis | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Insomnia | Review |
| 36590284 | To evaluate the efficacy and safety of acupuncture in treating symptoms for Cancer-related Insomnia(CRI) patients. | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Insomnia | Review |
| 36590284 | A heterogeneity test was first performed with P = 0.58, I2 = 0%, and a fixed-effect model was adopted for meta-analysis, which showed that acupuncture improved CRI patients better than controls in terms of sleep disturbances (RR = 0.47, 95%CI = [0.33, 0.66], P < 0.0001) (Figure 7). | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Insomnia | Review |
| 36590284 | Modern research has shown that the pathogenesis of insomnia is complex and closely related to the central nervous system (Bonnet and Arand,), and studies have shown that patients with insomnia often over-active the sympathetic nerves during sleep thus accelerating metabolism in the body (Liu et al.,), what's more, acupuncture can affect sleep by activating parasympathetic nerves and inhibiting sympathetic nerves (Li et al.,; Liu et al.,). | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Insomnia | Review |
| 36590284 | Meta-analysis of 11 RCTs studies of acupuncture for the treatment of symptoms in patients with CRI showed that acupuncture was effective in improving sleep disturbance and reducing PSQI scores, but it could not be stated whether it could reduce ISI scores, due to the small sample size included in this study and the low quality of the articles. | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Insomnia | Review |
| 36595758 | A systematic review and meta-analysis of acupuncture combined with Tuina in the treatment of insomnia | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Traditional Chinese medicine and modern medicine have their own advantages in the treatment of insomnia, and there is currently a lack of reports on the comparison of acupuncture combined with massage and conventional medicine. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | To evaluate the clinical efficacy of acupuncture combined with Tuina in the treatment of insomnia. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Search for clinical randomized controlled trials (RCTs) of acupuncture combined with Tuina in the treatment of insomnia from PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wan Fang Database, and China Science and Technology Journal Database. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Acupuncture combined with Tuina has obvious clinical advantages in the treatment of insomnia. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Traditional Chinese medicine (TCM) has a long history of clinical practice and diverse treatment methods in the treatment of insomnia including acupuncture, massage and traditional Chinese medicine decoction, etc. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | There are many clinical reports on the treatment of insomnia by non-drug methods such as acupuncture and massage. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Therefore, this study aims to use evidence-based medicine to analyze the literature of acupuncture combined with massage in the treatment of insomnia, objectively evaluate its clinical efficacy and safety, and provide a safe and reliable treatment plan for TCM clinical treatment of insomnia. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Subgroup analysis was performed between acupuncture combined with massage versus acupuncture alone, and acupuncture combined with massage versus conventional modern medicine for insomnia. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Based on the method of evidence-based medicine, this study conducted a systematic review on the total clinical efficacy rate, PSQI score, SDS score and SAS score of acupuncture combined with massage in the treatment of insomnia by collecting and sorting out literature. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | Acupuncture treatment of insomnia has received increasing attention in the past 2 decades. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | At the same time, acupuncture combined with massage to treat insomnia can reconcile the qi, blood, yin and yang of the whole body. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36595758 | At present, there are many deficiencies in clinical research on acupuncture for insomnia, such as confusion of disease names, inconsistent diagnostic criteria, and lack of targeted analysis of efficacy evaluation indicators. | Medicine (Baltimore). 2022 Dec 23;101(51):e30703. doi: 10.1097/MD.0000000000030703. | Insomnia | Review |
| 36704010 | Pricking and cupping plus antiepileptics, are the most effective acupuncture-related techniques for pain relief, while EA plus antiepileptics is the best acupuncture-related technique for improving PHN-related insomnia and depression symptoms. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Pain Relief Insomnia Depression | Review |
| 36704010 | In conclusion, for the sole purpose of relieving pain, the clinician should choose pricking and cupping plus antiepileptics, while PHN patients with negative emotions and insomnia should use electroacupuncture plus antiepileptics. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Insomnia Mood | Review |
| 36704010 | Moreover, EA plus antiepileptics is the best acupuncture-related technique for improving PHN-related insomnia and depression symptoms. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Insomnia Depression | Review |
| 36760792 | In terms of Pittsburgh Sleep Quality Scale score, the improvement in insomnia patients by tuina alone was better than that of other treatments [standardized mean difference (SMD), â2.57; 95% CI, â2.98, â2.17; P < 0.00001], and tuina combined with other treatments (acupuncture, scraping, auricular point pressing, Suanzaoren decoction, estazolam) was better than other single therapies (SMD, â2.83; 95% CI, â2.98, â2.68; P < 0.00001). | Front Neurosci. 2023 Jan 25;16:1096003. doi: 10.3389/fnins.2022.1096003. eCollection 2022. | Insomnia Sleep Quality | Review |
| 36760792 | The curative effect of pure tuina in treating insomnia is better than that of acupuncture, estazolam, TCM, and other treatments, and the curative effect of tuina combined with acupuncture, Suanzaoren decoction, estazolam, and other treatments is better than that of acupuncture alone. | Front Neurosci. 2023 Jan 25;16:1096003. doi: 10.3389/fnins.2022.1096003. eCollection 2022. | Insomnia | Review |
| 36760792 | However, there is not enough evidence to support that tuina alone is superior to acupuncture and auricular sticking alone in improving the efficacy in insomnia patients. | Front Neurosci. 2023 Jan 25;16:1096003. doi: 10.3389/fnins.2022.1096003. eCollection 2022. | Insomnia | Review |
| 36760792 | Our review included studies that used tuina plus acupuncture, herbal remedies, or medications to treat insomnia. | Front Neurosci. 2023 Jan 25;16:1096003. doi: 10.3389/fnins.2022.1096003. eCollection 2022. | Insomnia | Review |
| 36778899 | Apart from reducing pain, acupuncture may be beneficial for migraineurs with co-morbid problems such as anxiety, insomnia, and muscle tension. | Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. | Insomnia Anxiety | Review |
| 36864974 | The prevalence and trends of acupuncture used for treating cerebral infarction, stroke, insomnia, and low back pain have been identified worldwide. | Cardiovasc Diagn Ther. 2023 Feb 28;13(1):67-82. doi: 10.21037/cdt-22-480. Epub 2022 Dec 15. | Insomnia | Review |
| 36930068 | Treatment of insomnia based on the mechanism of pathophysiology by acupuncture combined with herbal medicine: A review | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | In this article, we discuss the combination of traditional Chinese medicine, acupuncture, and medicine to treat insomnia based on neurobiology in the context of modern medicine. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | There is scientific evidence that acupuncture can cause physiological changes in the heart, and from a modern medical perspective, these changes are related to the pathophysiology of insomnia. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Cognitive Behavioral Therapy for insomnia has been recommended as the first-line treatment for insomnia, and TCM treatment has both traditional herbal treatment components and non-pharmacological treatments, such as acupuncture and tui-na, emphasizing the combination of pharmacological and non-pharmacological treatments, which are compatible with cognitive behavioral therapy for insomnia in many aspects and can be mutually informed to promote understanding and treatment of insomnia. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Acupuncture for insomnia (Fig. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Numerous studies have shown that acupuncture improves sleep quality and prolongs sleep time in patients with insomnia by regulating the activities of sleep factors, such as neurotransmitters, hormones, and cytokines. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia Sleep Quality | Review |
| 36930068 | Acupuncture for insomnia. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Li Zhongwen et al designed a randomized controlled trial in which patients with insomnia were acupunctured by acupuncture of Shenmen and Sanyinjiao, and the results showed that acupuncture of sleep-Sanyinjiao could effectively improve sleep quality and upregulate serum γ-aminobutyric acid (GABA) and 5-HT levels in patients. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia Sleep Quality | Review |
| 36930068 | Li Wenkang et al used para-chlorophenylalanine (PCPA) model rats and designed animal experiments according to Experimental Acupuncture; the intervention group was selected to acupuncture bilateral Shenmen, Zhigou, Foot Sanli, and Sanyinjiao points to the inner umbilical ring points, and the results showed that this acupuncture method could improve insomnia symptoms in rats and could upregulate the PCPA model; the results showed that this acupuncture method could improve the symptoms of insomnia in rats, and could upregulate the expression of 5-HT1AR and 5-HT2AR in the hippocampus of the PCPA model. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Acupuncture, cytokines and insomnia. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Tang Lei et al used the electro-acupuncture method of 5 acupuncture points to randomly divide 40 PCPA model rats into control, model, electro-acupuncture, and diazepam groups, and the results showed that electro-acupuncture of Wuqi Yu could improve the symptoms of insomnia rats by promoting the synthesis of TNF-α and IL-1β in the hypothalamus and alleviating the inhibitory release of 5-HT and its metabolites caused by PCPA. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | After 4 weeks of treatment, the results showed that Jiaotai Pill combined with acupuncture could better regulate the levels of cytokines TNF-α, IL-6, and IL-1β and improve the sleep quality of patients and treatment of insomnia. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia Sleep Quality | Review |
| 36930068 | In contrast, acupuncture can affect sleep architecture, improve sleep quality, and treat insomnia by regulating hormones associated with the sympathetic-adrenomedullary system and the hypothalamic-pituitary-adrenal axis. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia Sleep Quality | Review |
| 36930068 | Li Jiahuan et al used the method of tuning Shen acupuncture and designed a randomized controlled trial in which 60 patients with insomnia were randomly assigned equally to the treatment group (acupuncture of Baihui, Shenting, Yintang, bilateral Shenmen, bilateral Sanyinjiao) and the control group (acupuncture of bilateral Handsanli, bilateral Fuyun, bilateral Feiyang), and after 4 weeks of treatment, it was found that both groups could improve patients insomnia symptoms, and The PSQI and Fatigue Severity Scale scores of the treated group were significantly lower, with better efficacy in improving insomnia and daytime fatigue, and the plasma melatonin and cortisol levels of patients in the treated group were reduced. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Combining acupuncture and herbal medicine for insomnia (Fig. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | In Chinese traditional medicine, both acupuncture and Chinese herbal medicine are effective in the treatment of neuropsychiatric disorders, but Chinese physicians tend to treat insomnia not in a single treatment, but more often in a combined form, most often with acupuncture combined with Chinese herbal medicine. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Combining acupuncture and herbal medicine for insomnia. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Ma et al collected 108 patients with insomnia of the heart and spleen deficiency type and divided them into a control group and a treatment group; the treatment group used the combined treatment and the control group used only the tranquilizing acupuncture method. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Yan Xueli et al used acupuncture (acupuncture of Si Shen Cong, an Mian, Shen Men, San Yin Jiao, Liver Yu, Lung Yu, Feng Chi, and Foot San Li) combined with Xiang Shu Tang (Xiang Shu, Chuan Xiong, Chai Hu, Qing Pi, Sour Jujube, and Hefei Pi) to treat 120 patients with perimenopausal insomnia of liver depression and qi stagnation, randomly and equally assigned into treatment and control groups. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia Depression | Review |
| 36930068 | The value of acupuncture in the treatment of insomnia has become increasingly widely recognized because some studies are based on modern medical research and because acupuncture points can quantify indicators and results to a certain extent, but it also has its own shortcomings. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36930068 | Cheng-Yong Liu et al designed a randomized controlled protocol of acupuncture combined with cognitive behavioral therapy for the treatment of insomnia. | Medicine (Baltimore). 2023 Mar 17;102(11):e33213. doi: 10.1097/MD.0000000000033213. | Insomnia | Review |
| 36950556 | Therefore, he proposed an integrative medicine (TCIM) including acupuncture and massage, to alleviate cancer symptoms or treatment-related adverse reactions such as pain, insomnia and fatigue. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Adverse Reactions Insomnia | Review |
| 36950556 | Existing systematic reviews have proved that acupuncture can not only relieve pain in patients with BC, but also improve hot flashes, fatigue, sleep disturbance, anxiety, and especially the quality of patients with BC. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Insomnia Anxiety | Review |
| 36969661 | One paper reported 11 adverse events in the trial group, including fatigue, sleep disturbance, and arm heaviness, and 8 adverse events in the same number of controls, including vomiting, flatulence, dreaming, and a feeling of coldness, which seemed to indicate that acupuncture had similar safety profile to placebo. | Front Public Health. 2023 Mar 9;11:1108756. doi: 10.3389/fpubh.2023.1108756. eCollection 2023. | Insomnia Nausea and Vomiting | Review |
| 37200784 | Dizziness, headache, nausea, vomiting, tachycardia, trembling hands, fatigue, depression, decreased appetite, decreased libido, lethargy or insomnia, excessive sedation or agitation, diarrhea or constipation, dry eyes or blurred vision, nasal congestion, and skin irritation were reported in the non-acupuncture group. | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Insomnia Nausea and Vomiting Depression Sedation | Review |
| 37200784 | Acupuncture was also reported to improve sleep disorders in PTSD insomnia rats by increasing the TNF content of the hypothalamus and decreasing IL4 expression (Wei et al.,). | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Insomnia | Review |
| 37229426 | 3 studies (Jiang et al.,; Chen et al.,; Han et al.,) reported that the incidence of side effects like dizziness, vomiting and insomnia in acupuncture combined with conventional medicines were lower than those in conventional medicines alone. | Front Neurosci. 2023 May 9;17:1125626. doi: 10.3389/fnins.2023.1125626. eCollection 2023. | Side Effects Insomnia Nausea and Vomiting | Review |
| 37441610 | Efficacy and safety of acupuncture on sleep quality for post-stroke insomnia: a systematic review and meta-analysis | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia Sleep Quality | Review |
| 37441610 | Acupuncture is widely used for the treatment of post-stroke insomnia in China. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Therefore, this systematic review and meta-analysis were performed to explore the efficacy and safety of acupuncture for post-stroke insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | While there is a high level of research-based evidence for acupuncture to treat insomnia or stroke-related sequelae, the existing systematic review (SR) conclusion on acupuncture to treat post-stroke insomnia still need to be applied with caution. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Studies have shown that acupuncture can improve the sleep quality of post-stroke insomnia patients. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia Sleep Quality | Review |
| 37441610 | The present systematic review and meta-analysis comprehensively summarize the efficacy and safety of acupuncture as a monotherapy or as adjunctive therapy in the treatment of post-stroke insomnia to guide evidence-based clinical decision-making. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | The most commonly used acupuncture points for post-stroke insomnia were GV20, HT7, SP6, GV24, EX-HN1, PC6, Anshen point, and GV29 (The sequencing of acupuncture points are provided in Supplementary Table S10). | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Post-infarction patients were the most represented subgroup of post-stroke patients, we evaluated the effects of acupuncture on post-infarction insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Five studies evaluated the improvement in total PSQI score of acupuncture for post-infarction insomnia, and the results showed marked improvement of acupuncture compared with sham acupuncture (SMD = â0.76, 95% CI: â1.08 to â0.43, P < 0.00001), when we attempted to pool the results of acupuncture compared with medium-acting BZDs (estazolam), the sensitivity analysis found that one study significantly affected the stability of the results, therefore, we conducted descriptive analysis and the result showed that two RCTs reported superior effects of acupuncture, and the other one reported equivalent effects. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Furthermore, five studies evaluated the improvement in PSQI total score of acupuncture plus CG for post-infarction insomnia, and the result indicated acupuncture plus non-BZDs (eszopiclone) (SMD = â0.67, 95% CI: â0.93 to â0.41, P < 0.0001) or plus medium-acting BZDs (estazolam) (SMD = â1.15, 95% CI â2.25 to â0.05, P = 0.04) had a better PSQI total score improvement than the control intervention (Figure 5). | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Effect of acupuncture for post-stroke insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | This study reviewed the efficacy, long-term effects, and safety of acupuncture for post-stroke insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Another study has shown that acupuncture can regulate MT content and MT1 and MT2 mRNA expression in the ventral lateral preoptic area of the hypothalamus of insomniac rats, thus improving insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | In addition, acupuncture can improve insomnia by increasing parasympathetic activity and inhibiting sympathetic activity, oxidative stress, and inflammation. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Follow-up data can reflect the long-term clinical effect, and we found that acupuncture treatment had long-term effect on improving PSQI scores in post-stroke insomnia at the 1st, 2nd, and 3rd month after the treatment. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | A total of 52 acupuncture points with frequencies ranging from 1 to 26 were used; the commonly used acupuncture points for post-stroke insomnia were GV20, HT7, SP6, GV24, EX-HN1, PC6, Anshen point, and GV29. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Despite these limitations and the low level of evidence, this meta-analysis provides valuable information regarding acupuncture in the post-stroke insomnia population. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | It also provides information on the long-term efficacy of acupuncture and its effects on special populations such as those with post-infarction insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Similar to the results of this study, previous SRs showed that acupuncture is effective and safe in treating post-stroke insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Third, follow-up data were included as outcome indicators to demonstrate the long-term clinical efficacy of acupuncture for post-stroke insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Finally, the current study successfully avoided the flaws of previous SRs and updated the evidence regarding the effects of acupuncture on post-stroke insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Second, different studies used different diagnostic criteria for insomnia, such as the DSM-5, CCMD-3, and ICD-10, which may have affected the evaluation of the acupuncture effect. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | We suggest using acupuncture or acupuncture combined with short-term, intermittent, or low-dose sleeping pills for the treatment of post-stroke insomnia in the future; however, more studies are needed to identify the guidelines for sleeping pills (such as dose, course of treatment, and frequency) when in combination with acupuncture. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia | Review |
| 37441610 | Third, acupuncture can improve sleep quality and has long-term efficiency; moreover, it can also relieve other stroke sequelae such as depression to avoid aggravating insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia Depression Sleep Quality | Review |
| 37441610 | This study suggested that acupuncture has positive effects on subjective sleep quality, long-term clinical efficacy in post-stroke insomnia. | Front Neurol. 2023 Jun 27;14:1164604. doi: 10.3389/fneur.2023.1164604. eCollection 2023. | Insomnia Sleep Quality | Review |
| 37510483 | Our meta-analysis suggests that acupuncture can be used as a complementary treatment for sleep disturbances and depression in PD patients and may exhibit a dual therapeutic effect on motor and non-motor symptoms. | Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. | Insomnia Depression | Review |
| 37510483 | A recent meta-analysis found that combining acupuncture with medication may be more effective in improving PD-related insomnia and depression than medication alone. | Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. | Insomnia Depression | Review |
| 37525791 | In a meta-analysis that evaluated the impact of different traditional Chinese medicine techniques on symptom management and quality of life in cancer patients, acupuncture was found to have a varying degree of effectiveness in alleviating adverse symptoms such as pain, fatigue, sleep disturbance, and gastrointestinal discomfort. | Cureus. 2023 Jun 30;15(6):e41203. doi: 10.7759/cureus.41203. eCollection 2023 Jun. | Insomnia | Review |
| 37533466 | Effects of acupuncture on the brain in primary insomnia: a coordinate-based meta-analysis of fMRI studies | Front Neurol. 2023 Jul 18;14:1180393. doi: 10.3389/fneur.2023.1180393. eCollection 2023. | Insomnia | Review |
| 37533466 | One notable finding was that frontal lobe activation appears to be both a key pathological feature of patients with PI and an important mechanism for the effect of acupuncture on insomnia. | Front Neurol. 2023 Jul 18;14:1180393. doi: 10.3389/fneur.2023.1180393. eCollection 2023. | Insomnia | Review |
| 37533466 | Unexpectedly, several brain regions with increased ALFF and ReHo levels were also found after both acupuncture and non-acupoint acupuncture treatment, which were associated with a reduction in insomnia symptoms. | Front Neurol. 2023 Jul 18;14:1180393. doi: 10.3389/fneur.2023.1180393. eCollection 2023. | Insomnia | Review |
| 37542321 | Although there is evidence that acupuncture can prevent and relieve migraine and concomitant symptoms such as depression and sleep disturbances, several long-term follow-ups of high-quality RCTs indicate that acupuncture improves the frequency of migraine attacks and the length of the headache, but do not specify whether the long-term follow-up after treatment could improve the mental health of patients; therefore, the long-term effectiveness of acupuncture in improving mental health in migraine patients is unclear. | BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. | Insomnia Depression | Review |
| 37614343 | Acupuncture in insomnia treatment improves sleep quality and psychological health. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Insomnia Sleep Quality | Review |
| 37614343 | The effect of Mongolian medical warm acupuncture (MMWA) on insomnia is related to the regulation of miR-101a and PAX8. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Insomnia | Review |
| 37614343 | Mongolian warm acupuncture (MWA) in a rat model of insomnia improved sleep and the expression levels of Egr1, Btg2, and brain-derived neurotrophic factor (BDNF) in the hypothalamus increased in the MWA treated group. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Insomnia | Review |
| 37614343 | Manual acupuncture (MA) stimulation enhanced the sleep disorder phenotype in a rat model of insomnia and had a substantial effect on the recovery of the gut microbiota. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Insomnia | Review |
| 37614343 | The effect of electroacupuncture treatment (EA) improving sleep disturbance was evaluated in rats with insomnia. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Insomnia | Review |
| 37614513 | Previous studies have reported various acupuncture techniques for managing various tumor-related complications, such as pain, fatigue, insomnia, and so on. | Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. | Insomnia | Review |
| 37637184 | Finally, previous reviews have shown that acupuncture can be effective in treating opioid use disorder; EA can alleviate cravings for opioids and depression, and TEAS can mitigate symptoms of insomnia and anxiety. | Integr Med Res. 2023 Sep;12(3):100976. doi: 10.1016/j.imr.2023.100976. Epub 2023 Jul 28. | Insomnia Anxiety Depression | Review |
| 37675019 | A systematic review of randomized controlled trials showed that acupuncture had demonstrated efficacy in alleviating sleep disturbance, fatigue, and UP symptoms among patients with CKD. | Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. | Insomnia | Review |
| 37675019 | Various meta-analyses, which included thousands of patients each, suggested that acupuncture could improve the sleep quality of patients with primary insomnia and patients with insomnia-related primary diseases and conditions (stroke, ESRD, perimenopause, pregnancy, and mental illness) of all ages, with few and mild adverse reactions. | Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. | Adverse Reactions Insomnia Sleep Quality | Review |
| 37732301 | Notably, clinical investigations have ascertained that the mechanism underlying the efficacy of electroacupuncture at DU29 for addressing insomnia and chronic pain could be attributed to the direct entry of nerve impulses into the brain post-acupuncture. | Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. | Insomnia | Review |
| 37810054 | But the total number is still insufficient compared with the number of publications focused on acupuncture therapy for knee osteoarthritis, low back pain, and insomnia. | Heliyon. 2023 Sep 1;9(9):e19732. doi: 10.1016/j.heliyon.2023.e19732. eCollection 2023 Sep. | Insomnia | Review |
| 37810054 | Additionally, according to other bibliometric analyses of using acupuncture treating diseases like insomnia and knee osteoarthritis, acupuncture therapy has already become the essential point with the highest centrality. | Heliyon. 2023 Sep 1;9(9):e19732. doi: 10.1016/j.heliyon.2023.e19732. eCollection 2023 Sep. | Insomnia | Review |
| 37810368 | Moreover, acupuncture regulates neurotransmitter release, immune inflammatory reactions, and HPA axis activity to improve anxiety, depression, and insomnia. | Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. | Immunity Insomnia Anxiety Depression | Review |
| 37861514 | Efficacy of acupuncture or moxibustion in treating senile insomnia compared with a control group: A systematic review and meta-analysis | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | This systematic review and meta-analysis aimed to assess the efficacy of acupuncture or moxibustion therapy in senile insomnia patients. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | A comprehensive literature search was conducted using 7 electronic databases to identify randomized controlled trials reported on the use of acupuncture or moxibustion therapy in insomnia. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | This meta-analysis revealed that acupuncture or moxibustion alone or combination with other therapies(drugs, CBT-I or psychological intervention) has high clinical efficacy and can improve the sleep quality of patients with senile insomnia. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia Sleep Quality | Review |
| 37861514 | Acupuncture and moxibustion are part of external treatment and have been widely used to treat senile insomnia in traditional Chinese medicine. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | Studies have reported that the use of acupuncture and moxibustion in the treatment of insomnia has the advantages of accurate efficacy, simple operation, and fewer adverse reactions. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Adverse Reactions Insomnia | Review |
| 37861514 | This systematic review and meta-analysis demonstrated the efficacy of acupuncture and moxibustion in the treatment of senile insomnia. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | Randomized controlled trials (RCTs) assessing the efficacy of acupuncture or moxibustion in the treatment of senile insomnia were included based on the following criteria: types of participants: Patients (age, â¥60 years) with senile insomnia irrespective of race and sex; types of studies: RCTs and studies in which blinding and allocation concealment were not limited; and types of interventions: The experimental group was treated with acupuncture, electroacupuncture, or moxibustion alone or acupuncture combined with other therapies, whereas the control group was treated with sham acupuncture alone, placebo, or other therapies used in the treatment group; types of outcomes: Primary outcomes included the rate of improvement and the Pittsburgh Sleep Quality Index (PSQI) score. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia Sleep Quality | Review |
| 37861514 | This systematic review and meta-analysis aimed to assess the effectiveness of acupuncture or moxibustion in treating senile insomnia. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | The results of 20 RCTs involving 1677 patients with senile insomnia showed that acupuncture or moxibustion treatment was more effective in ameliorating insomnia and improving PSQI scores than conventional medicine, CBT-I, or psychological intervention. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | Acupuncture or moxibustion alone or combination with drugs may be more effective in treating senile insomnia than drugs alone. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37861514 | Since there was only one study in which the control group was sham acupuncture, CBT-I, or psychological intervention, the result is unconvincing that acupuncture is better than the above therapies in the treatment of senile insomnia. | Medicine (Baltimore). 2023 Oct 20;102(42):e34842. doi: 10.1097/MD.0000000000034842. | Insomnia | Review |
| 37928412 | Acupressure and acupuncture are based on the same TCM theories of improving sleep disturbance by unblocking meridians and balancing Yin and Yang. | Asia Pac J Oncol Nurs. 2023 Sep 18;10(11):100308. doi: 10.1016/j.apjon.2023.100308. eCollection 2023 Nov. | Insomnia | Review |
| 37960761 | Acupuncture combined with Chinese herbal medicine in the treatment of perimenopausal insomnia: A systematic review and meta-analysis | Medicine (Baltimore). 2023 Nov 10;102(45):e35942. doi: 10.1097/MD.0000000000035942. | Insomnia | Review |
| 37998449 | Preclinical animal studies utilizing acupuncture to treat animal models of PTSD have shown promising results, including improvements in anxiety, fear, sleep disturbances, cognitive symptoms, and depression. | Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. | Insomnia Anxiety Depression | Review |
| 37998449 | King, Moore, and Spence (2016) aimed to explore the factors that contribute to improved sleep in veterans with PTSD-related insomnia undergoing acupuncture in a follow-up to their previous study. | Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. | Insomnia | Review |
| 38125837 | Fifteen experimental studies in three categories for improving sleep in PLWH were included finally, including psychological interventions (components of cognitive-behavioral therapy for insomnia or mindfulness-based cognitive therapy, n = 6), physical interventions (auricular plaster therapy, acupuncture, and exercise, n = 8), and elemental interventions (speed of processing training with transcranial direct current stimulation, n = 1). | Front Neurol. 2023 Nov 20;14:1017896. doi: 10.3389/fneur.2023.1017896. eCollection 2023. | Insomnia | Review |
| 38125837 | Therefore, the safety of acupuncture in treating patients with HIV/AIDS and insomnia should be a key consideration. | Front Neurol. 2023 Nov 20;14:1017896. doi: 10.3389/fneur.2023.1017896. eCollection 2023. | Insomnia | Review |
| 38189090 | Future research could focus on the role of acupuncture for functional capacity, insomnia, and pain in CKD patients. | Ren Fail. 2024 Dec;46(1):2301504. doi: 10.1080/0886022X.2023.2301504. Epub 2024 Jan 8. | Insomnia | Review |
| 38213582 | Bibliometric analyses has already been applied across many acupuncture-related medical research fields, including fibromyalgia, insomnia, and magnetic resonance imaging. | Heliyon. 2023 Nov 23;9(12):e22799. doi: 10.1016/j.heliyon.2023.e22799. eCollection 2023 Dec. | Insomnia | Review |
| 25047046 | To continue this trend it is important note that the quality and speed of post anaesthetic recovery is influenced by multiple factors such as the occurrence of pain, postoperative nausea and vomiting (PONV), paralytic ileus, fatigue and sleep disturbances. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Insomnia Nausea and Vomiting | Clinic |
| 23342207 | Pain can cause patients to feel uncomfortable resulting in sleeplessness or agitation. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Insomnia | Clinic |
| 27688791 | ); moderate-sized body mass index of 18.5xe2x80x9323.9 (Chinese); no history of nervous system disease; (4) no pain (including dysmenorrhea) or insomnia within 1 month before the test; (5) no metallic substances in the body, such as stents; (6) no noise exposure and hypothermia; no fear of confined spaces; (7) no acupuncture procedure within 1 month before the test. | Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. | Insomnia Hypothermia | Clinic |
| 30356057 | To enhance recovery, it is recommended to prevent or minimize the occurrence of pain, post-operative nausea and vomiting (PONV), paralytic ileus, fatigue and sleep disturbances. | Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. | Insomnia Nausea and Vomiting | Clinic |
| 30425466 | Perioperative opioids have been linked to sleep disturbances, which may negatively impact cognitive function. | Clin Interv Aging. 2018 Oct 24;13:2127-2134. doi: 10.2147/CIA.S183698. eCollection 2018. | Cognitive Function Insomnia | Clinic |
| 33154688 | Postoperative sleep disturbances have serious adverse effects on postoperative outcomes. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Adverse Reactions Insomnia | Clinic |
| 33154688 | The visual analog scale (VAS) was performed to evaluate pain scores after surgery and the Athens Insomnia Scale (AIS) was used for evaluating subjective sleep quality. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia Sleep Quality | Clinic |
| 33154688 | Patients usually have sleep disturbances after video-assisted thoracoscopic surgery, such as decreased distribution of each sleep stage, lower sleep efficiency, and higher AIS score. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia | Clinic |
| 33154688 | Postoperative sleep disturbances (POSD) are defined as changes in the sleep structure and quality of patients during the early stages after surgery, which are manifested as significantly shortened rapid eye movement (REM) sleep, prolonged awake time, and sleep fragmentation. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia | Clinic |
| 33154688 | The following participants were excluded: (1) patients with central nervous system and mental diseases; (2) patients with preoperative sleep disturbances; (3) patients with a history of sedative, analgesic, or antidepression drug use; (4) patients with sleep apnea or moderate and severe obstructive sleep apnea-hypopnea syndrome; (5) patients with sinus bradycardia or atrioventricular block grade II or greater; and (6) patients with severe visual or hearing impairment or who were unable to communicate. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia Depression | Clinic |
| 33154688 | According to the primary outcome of the Athens Insomnia Scale (AIS) score between the two groups and the calculation of the sample size by the formula (n1 = n2 = 2 xc3x97 [(1.96 + 0.842) xc3x97 xcexb4/xcfx83]2), 0.54 was chosen as the estimated variability between the two groups, and 0.8 was chosen as the standard deviation. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia | Clinic |
| 33154688 | It comprises eight items: sleep induction, waking during the night, final awakening, total sleep duration, sleep quality, well-being, functioning capacity, and sleepiness during the day, and the total AIS scores range from 0 to 24 points, with xe2x89xa56 points indicating a diagnosis of insomnia. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia Sleep Quality | Clinic |
| 33154688 | AIS: The Athens Insomnia Scale; Sleep efficiency: the ratio of total sleep time/total recording time. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia | Clinic |
| 33154688 | In our study, we found that patients in both groups presented a lower sleep efficiency and a higher AIS score characterized by a decreased proportion of each sleep stage during Sleep POD 1 and Sleep POD 3, as compared with Sleep-preop 1, which was similar to the finding of Lin et al, who reported that sleep disturbances are frequently observed during the postoperative period in patients who have undergone open thoracotomy or minimally invasive surgery. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia | Clinic |
| 33154688 | Rat studies have shown that electroacupuncture can improve sleep quality by restoring normal neurotransmitters (eg, 5-HT and 5-hydroxyindoleacetic acid), interleukin-1xcexb2, and tumor necrosis factor levels, and decreasing norepinephrine and dopamine levels in the brain of an insomnia rat model. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia Sleep Quality | Clinic |
| 33154688 | In conclusion, patients undergoing video-assisted thoracoscopic surgery experienced marked postoperative sleep disturbances, characterized by higher AIS scores, lower sleep efficiency, and decreased proportions of each sleep phase. | Nat Sci Sleep. 2020 Oct 27;12:809-819. doi: 10.2147/NSS.S270739. eCollection 2020. | Insomnia | Clinic |
| 31225736 | Effect of Mongolian warm acupuncture on the gene expression profile of rats with insomnia. | Acupunct Med. 2019 Oct;37(5):301-311. doi: 10.1136/acupmed-2016-011243. Epub 2019 Jun 21. | Insomnia | Mechanism |
| 31225736 | BACKGROUND: The mechanism of Mongolian warm acupuncture (MWA) for the treatment of insomnia has not been previously reported. | Acupunct Med. 2019 Oct;37(5):301-311. doi: 10.1136/acupmed-2016-011243. Epub 2019 Jun 21. | Insomnia | Mechanism |
| 31225736 | OBJECTIVE: To investigate the effect of MWA on gene expression profile in the p-chlorophenylalanine (PCPA)-induced rat model of insomnia. | Acupunct Med. 2019 Oct;37(5):301-311. doi: 10.1136/acupmed-2016-011243. Epub 2019 Jun 21. | Insomnia | Mechanism |
| 31225736 | METHODS: A rat model of insomnia was established and the animals were divided into five groups: control, PCPA (untreated), PCPA+estazolam, PCPA+MA (manual acupuncture), and PCPA+MWA. | Acupunct Med. 2019 Oct;37(5):301-311. doi: 10.1136/acupmed-2016-011243. Epub 2019 Jun 21. | Insomnia | Mechanism |
| 31225736 | CONCLUSION: In combination, the findings of this study suggests that MWA is efficacious at improving sleep in an experimental rat model of insomnia. | Acupunct Med. 2019 Oct;37(5):301-311. doi: 10.1136/acupmed-2016-011243. Epub 2019 Jun 21. | Insomnia | Mechanism |
| 36156370 | These results indicate that the alleviation of endoplasmic reticulum stress in the medial septum by HT7 stimulation and the subsequent amelioration of insomnia may depend on phosphorylated TrkB activation. | Biomed Pharmacother. 2022 Nov;155:113724. doi: 10.1016/j.biopha.2022.113724. Epub 2022 Sep 23. | Insomnia | Mechanism |
| 37519181 | Chronic pain may restrict activities of daily living, including work, learning, social life, and can lead to anxiety, depression, and sleep disturbance. | J Integr Neurosci. 2023 Jul 17;22(4):97. doi: 10.31083/j.jin2204097. | Insomnia Anxiety Depression | Mechanism |
| 35482778 | Influence of warm acupuncture on gut microbiota and metabolites in rats with insomnia induced by PCPA | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Insomnia is the most common of the sleep disorders. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Mongolian medical warm acupuncture (MMWA) is an emerging therapeutic option for treating insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | However, the underlying mechanisms responsible for the anti-insomnia efficacy of the MMWA remain unclear. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | This study aims to investigate the effect of the MMWA on the alterations of the gut microbiota and serum metabolome in rats with insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | We found that the relative abundances of gut bacteria and the concentrations of several serum metabolites were obviously altered in PCPA-induced insomnia rats. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | The MMWA treatment exerted an anti-insomnia effect. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Correlation analysis between the gut microbiota and metabolites suggested that the levels of Amide c18, Benzoyl chloride, Cytosine, and N, n-dimethylarginine were positively correlated with the relative abundance of Clostridium XlVa and Blautia, which characterized the insomnia rats. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | KEGG enrichment analysis identified the cAMP signaling pathway involving anti-insomnia effect of the MMWA. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | The present study could provide useful ideas for the study of the intervention mechanisms of the MMWA in insomnia rat models. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Accumulating evidence indicated that insomnia was associated with a wide range of negative health consequences, such as mental disorder, cardiovascular dysfunction, type 2 diabetes, and obesity. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Cardiovascular Insomnia | Mechanism |
| 35482778 | Many studies have suggested that multifactorial causes are involved in the etiology of insomnia, and the detailed pathological aspects of insomnia remain unclear. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | It was reported that the structure, composition, and function of the gut microbiota, as well as the bacterial interaction network were significantly changed in insomnia patients. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | These studies provide a theoretical basis for the application and development of novel strategies for insomnia therapy. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Mongolian medicine, one of the traditional medicines, showed a favorable safety profile and beneficial therapeutic effects on insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | In Mongolian medicine, warm acupuncture is one of the main treatment methods for insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | It has been widely accepted by insomnia patients due to its advantages, such as efficiency, safety, and no drug dependence. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Another study reported that acupuncture might be beneficial for insomnia through modulating the gut microbiota to regulate the host inflammatory response. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | However, the role of the gut microbiota and its metabolites on the effects of the Mongolian medicine warm acupuncture (MMWA) in insomnia is still unknown. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Our study aims to investigate the effects of the MMWA on the gut microbiota and metabolites in p-chlorophenylalanine (PCPA)-induced insomnia rats, which may help to elucidate the biological mechanisms of the gut microbiota-mediated sleep regulation. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | For the PCPA-induced insomnia model, rats received PCPA (300 mg/kg, dissolved in saline) via intraperitoneal injection in the morning of each day for 3 consecutive days. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Acupoint Heyi is often used to treat palpitation, agitation, and insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Acupoint Xin is stimulated to alleviate delirium, anorexia, and insomnia in traditional Mongolian medicine. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Recent studies have verified that stimulating these three acupoints improves the sleep quality of rats with PCPA-induced insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia Sleep Quality | Mechanism |
| 35482778 | Rats were weighed before the establishment of the insomnia model and at the end of the experiment. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | The insomnia model was induced by PCPA as described previously. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | MMWA treatment ameliorates insomnia induced by PCPA in rats | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | As shown in Fig 1A, the insomnia models exhibited less food intake and lower weight gain when compared with the control group (P < 0.05). | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | These results indicated that the MMWA had a therapeutic effect on insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | The therapeutic effect of the MMWA on insomnia rats. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | MMWA treatment improves gut microbiota in PCPA-induced insomnia rats | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | MMWA treatment regulates serum metabolites in PCPA-induced insomnia rats | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | KEGG pathway enrichment analysis showed that the occurrence of insomnia was associated with multiple pathways, among which the metabolic pathways and signaling pathways were considered to be especially important (Fig 6A). | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | In contrast, the MMWA treatment could modify the cAMP signaling pathway to exert beneficial effects on insomnia (Fig 6B). | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | To verify the effects of MMWA on cAMP levels in PCPA-induced insomnia rats, the concentrations of cAMP were evaluated using ELISA. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Compared with the control group, the levels of cAMP were significantly increased in PCPA-induced insomnia rats (P < 0.05). | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | As shown in Table 1, the metabolites, such as Amide c18, Benzoyl chloride, Cytosine, and N, n-dimethylarginine were obviously increased in insomnia rats and showed a positive correlation with Clostridium XlVa and Blautia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | MMWA treatment elevates the butyrate level in PCPA-Induced insomnia rats | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | To verify the effects of butyrate on cAMP levels in PCPA-induced insomnia rats, sodium butyrate was administered to the insomnia rats. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | MMWA treatment reduces the GABA transporter 1 (GAT-1) expression in PCPA-induced insomnia rats | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Although the MMWA therapy has been historically used for the treatment of insomnia, the understanding of the underlying mechanisms is still limited. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | More recently, the results of multiple studies have demonstrated that the gut microbiota and its related metabolites played important roles in the pathogenesis of insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | The aim of this study is to evaluate the therapeutic effect of the MMWA and to elucidate its anti-insomnia mechanism from the perspective of intestinal flora and metabolomics. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | In our study, the insomnia rat models induced by PCPA were established. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | It is well known that dysfunction of neurotransmitters is nearly concerned with insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | 5-HT and GABA have been found to decrease significantly in brains of insomnia, whereas the levels of ACh and NE increased. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Therefore, our observations suggested that the intervention of the MMWA had a satisfactory effect on insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | At the genus level, a drastic decrease in the relative abundance of the genera Lactobacillus and Clostridium sensu stricto were detected in insomnia rats when compared with the controls. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Moreover, the abundance of Romboutsia was observed to increase in insomnia rats. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | However, the association between Romboutsia and insomnia in rats has yet to be elucidated. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | To the best of our knowledge, the roles of Clostridium XlVa in insomnia have not been reported yet. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | To further verify whether the MMWA treatment rebalances the intestinal flora in the insomnia rat models induced by PCPA, the LDA scores based on LEfSe analysis were obtained between the control and the treatment groups. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | The alteration of the gut microbiota in insomnia rats was accompanied by the disorders of serum metabolome, as described in other studies. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | Correlation analysis demonstrated that the metabolites elevating in insomnia rats, such as Amide c18, Benzoyl chloride, Cytosine, and N, n-dimethylarginine were positively associated with the abundance of Clostridium XlVa and Blautia, which characterized the insomnia rats. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | These results further confirmed that these bacteria might play an essential role in insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | We then examined the effect of the MMWA intervention on the butyrate level in insomnia rats. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | It is well known that GABAergic synapse contributed to the development of insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | The present study suggested that the MMWA intervention could regulate a variety of microbial genera and metabolites related to insomnia, resulting in the reversal of butyrate-mediated abnormalities of the cAMP signaling pathway and GAT-1 expression (Fig 8). | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 35482778 | These findings would provide a better understanding of the molecular mechanism underlying the intervention of MMWA as an effective therapy for insomnia. | PLoS One. 2022 Apr 28;17(4):e0267843. doi: 10.1371/journal.pone.0267843. eCollection 2022. | Insomnia | Mechanism |
| 33645011 | Emerging literature indicated that acupoint catgut embedding could benefit people with abdominal obesity, insomnia and diabetic gastroparesis, 10 , 11 , 12 and improves dysmenorrhoea in primary dysmenorrhoea rats by inhibiting the activation of NLRP3 inflammasome in the uterine tissue, 13 improve changes of structure of hippocampal neurons in senile chronic stress rats. | J Cell Mol Med. 2021 Apr;25(8):3816-3828. doi: 10.1111/jcmm.16295. Epub 2021 Mar 1. | Insomnia | Mechanism |
| 32249904 | iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Objective: To explore the proteomic changes in the hypothalamus of rats treated with Mongolian medical warm acupuncture for insomnia therapy based proteomics. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Method: We used an iTRAQ-based quantitative proteomic approach to identify proteins that potential molecular mechanisms involved in the treatment of insomnia by Mongolian medical warm acupuncture. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Result: In total, 7477 proteins were identified, of which 36 proteins showed increased levels and 45 proteins showed decreased levels in insomnia model group (M) compared with healthy control group (C), 72 proteins showed increased levels and 44 proteins showed decreased levels from the warm acupuncture treated insomnia group (W) compared with healthy controls (C), 28 proteins showed increased levels and 17 proteins showed decreased levels from the warm acupuncture-treated insomnia group (W) compared with insomnia model group (M). | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Compared with healthy control groups, warm acupuncture-treated insomnia group showed obvious recovered. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Proteins showed that increased/decreased expression in the warm acupuncture-treated insomnia group included Prolargin (PRELP), NMDA receptor synaptonuclear-signaling and neuronal migration factor (NSMF), Transmembrane protein 41B (TMEM41B) and Microtubule-associated protein 1B (MAP1B) to adjust insomnia. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Conclusion: A combination of findings in the present study suggest that warm acupuncture treatment is efficacious in improving sleep by regulating the protein expression process in an experimental rat model and may be of potential benefit in treating insomnia patients with the added advantage with no adverse effects. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Adverse Reactions Insomnia | Mechanism |
| 32249904 | Insomnia also leads to diseases such as hypertension, low immune function and diabetes. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Immunity Insomnia | Mechanism |
| 32249904 | The current understanding of clinical science on insomnia is limited, and hypnotics are primarily used for treatment. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Mongolian medicine annals documentation and modern clinical studies have proven the effectiveness of Mongolian medical warm acupuncture in treating insomnia, and have shown that it is safer than hypnotics as it does not possess any side effects. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects Insomnia | Mechanism |
| 32249904 | However, the specific mechanism warm acupuncture-treated insomnia of remains unclear. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Therefore, in order to study the molecular mechanism of Mongolian medical warm acupuncture in the treatment of insomnia, in the present study we employed proteomics technologies as a new systems biology tool for the first time. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Using iTRAQ-based proteomics, the present study explored the proteomic changes in the hypothalamus of rats treated with Mongolian medical warm acupuncture for insomnia therapy. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | The animals were divided into three groups: the normal control group (C), the insomnia model group (M) and the warm acupuncture-treated insomnia group (W). | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | The results obtained by systems analysis, and the potential molecular mechanisms involved in the treatment of insomnia by Mongolian medical warm acupuncture are discussed. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Insomnia rat model construction | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Then, the animals were randomly divided into three groups (n=10/group): healthy controls (C), insomnia model group (M) and the warm acupuncture-treated insomnia group (W). | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Rats in the M and W groups use peritoneal injection of p-chlorophenylalanine (300 mg/ kg) to construct the insomnia rat model, and the dosage was adjusted with the increase in body weight. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Moreover, these four proteins were found to be closely related to neuroregulation or insomnia treatment. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Among them, prolactin protein prolactin (prelp), which has been shown to be closely related to insomnia treatment, is the focus of our future research. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Insomnia is a subjective experience of sleep and is characterized by a difficulty in falling and/or staying asleep. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Insomnia is the most common sleep disorder and is associated with high rates of morbidity. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Therefore, finding a safe and effective way to treat insomnia will be the focus of future research. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Mongolian medical warm acupuncture is one of the most commonly used methods for treatment of insomnia in Mongolian medicine. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Mongolian medicine annals documentation and modern clinical studies have proven the effectiveness of Mongolian medical warm acupuncture in treating insomnia, and have shown that it is safer than hypnotics as it does not possess any side effects. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects Insomnia | Mechanism |
| 32249904 | Thus, treatment of insomnia using Mongolian medical warm acupuncture has been widely accepted by the patients due to its advantages such as high efficiency, safety, no side effects, simplicity and no drug dependence. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects Insomnia | Mechanism |
| 32249904 | In the present study, the effects of warm acupuncture treat with insomnia rat hypothalamus proteome were investigated, and the data obtained were integrated with related biological information in an attempt to reveal the molecular mechanisms involved in Mongolian medical warm acupuncture for insomnia therapy. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | The recent advances in proteomics technologies have provided useful tools for studying the mechanisms of insomnia, which can contribute to the development of insomnia treatments that can be potential applied in clinical practice. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | In insomnia studies, proteomics has been mainly used to identify physiopathologic mechanisms associated with insomnia and its developing process; however, there is no information on the proteome changes in response to Mongolian medical warm acupuncture. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | In the present study, iTRAQ-based proteomics analysis was performed to study the proteome changes associated with the application of Mongolian medical warm acupuncture in insomnia treatment. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | The experimental insomnia animal model and the quality control were labeled by different iTRAQ labeling reagents in order to detect meaningful changes in proteins, and further bioinformatics analysis was performed to obtain the related biological function of the identified proteins. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | This indicated that warm acupuncture treatment of insomnia involves regulation of nerve signal transduction, growth, and regeneration in rats. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | We also found GO function enrichment in immune responses, suggesting that Mongolian medical warm acupuncture treated insomnia through up-regulation of immunologic response mechanisms. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Immunity Insomnia | Mechanism |
| 32249904 | Furthermore, enrichment was observed in the GO molecular function annotations of nerve conduction electrical carrier activation, antioxidant activity activation, catalytic activation and intermembrane transduction activation, implying that during Mongolian medical warm acupuncture treatment of insomnia rats, nerve signal transduction was stimulated, inter membrane transduction was activated, and the electrical signal conduction was up-regulated. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Cellular composition GO analysis revealed enrichment of cell membrane, synapse, intermembrane tissue, supramolecular complex, intermembrane space, and cell junctions, which further indicated differential expression of proteins located in cell membrane and intermembrane space, during Mongolian medical warm acupuncture treatment of insomnia rats. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Additionally, enrichment was observed in cell membranes, cell membrane receptor proteins and complicated mesh frame structures composed of signaling polysaccharide macromolecules, which are vital for neurotransmission and signal conduction; thus, cell membrane proteins play vital roles in Mongolian medical warm acupuncture treatment of insomnia. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | These results also suggested that extracellular matrix proteins are implicated in the initiation and progression of insomnia. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Down-regulation of oxytocin protein has been reported to correlate with depression, insomnia and neural regulation. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia Depression | Mechanism |
| 32249904 | PRELP (Prolargin) related to neural regulation, decreased prolactin is associated with depression and insomnia. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia Depression | Mechanism |
| 32249904 | In the present study, the expression of prolactin increased under warm acupuncture, which is one of the ways to alleviate insomnia. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Treatment with warm acupuncture can repair neurodevelopmental that is one of the ways to alleviate insomnia. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | The iTRAQ-based proteomic data analyses presented here elucidate variations of the proteomics involved in the treatment of insomnia by Mongolian medical warm acupuncture. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | Distinct protein played an important role in the treatment of insomnia by Mongolian medical warm acupuncture. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | It may through regulatory mechanisms of neuronal function on insomnia. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 32249904 | It also reveals the potential molecular mechanisms associated with the treatment of insomnia by Mongolian medical warm acupuncture. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Insomnia | Mechanism |
| 21625423 | In its late stage PD destroys multiple regions of the brain except for the nigrostriatal system, which leads to complex clinical symptoms such as pain and insomnia. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Insomnia | Mechanism |
| 24321617 | Notwithstanding its widespread use, l-dopa produces adverse effects, including hallucination, insomnia, nausea, and dyskinesia. | Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. | Adverse Reactions Insomnia Nausea and Vomiting | Mechanism |
| 30151295 | Major depressive disorder is a common and is characterized by various symptoms, such as depressed or irritable mood, decreased interest in activities, inability to experience pleasure, loss of appetite, sleep disturbances, and inappropriate feelings of guilt and worthlessness. | J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. | Insomnia Mood | Mechanism |
| 28672928 | Mechanism of Mongolian medical warm acupuncture in treating insomnia by regulating miR-101a in rats with insomnia | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | MicroRNAs (miRNAs or miRs) and the target genes before and after warm acupuncture at the genetic level were assessed, and the cytokines and neurotransmitters related to insomnia were studied. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Male Sprague-Dawley rats were used to create PCPA insomnia rat models and randomly divided into the normal, model, warm acupuncture, and drug groups. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The differential expression profile of microRNA in the brain tissue of the insomnia rats was determined before and after Mongolian medicine warm acupuncture for establishment of miR-101a mimics and inhibitor. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The expression level of miR-101a in the cells of the hippocampus of the insomnia rats transfected with miR-101a mimics increased significantly at 72 h (P<0.05). | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The western blotting result indicated that the expression of the PAX8 protein in the neuronal cells of the insomnia model rats was inhibited and downregulated significantly at 72 h after addition of miR-101a mimics compared with that in the scramble added group (P<0.01). | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Insomnia is a subjective experience characterized by a difficulty in falling asleep and/or staying asleep, which results in the failure of sleep quality or quantity to meet an individual's normal physiological needs and affects their social functions. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia Sleep Quality | Mechanism |
| 28672928 | Thus, effective prevention and treatment of insomnia is a main focus of research in the world. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Mongolian medicine has a unique mechanism and good efficacy in treatment of insomnia. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | In the Mongolian medicine, the treatment of insomnia mainly focuses on relieving Heyi and regulating Heyi, Xila, and Badagan. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The warm needling therapy is one of most common methods for the treatment of insomnia in Mongolian medicine as it functions in warming and smoothing meridians, regulating qi and blood, regulating voxels, enhancing immunity, and preventing and treating diseases. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Immunity Insomnia | Mechanism |
| 28672928 | Thus, the warm needling therapy has considerable advantages in the treatment of insomnia, such as significant efficacy, safety, simplicity, and economy. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Our study first investigates the role of the Mongolian medical warm acupuncture in hypnotizing the PCPA-induced insomnia models. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Finally, we observed the insomnia-related cytokines and neurotransmitter content, probed into the biological foundation of Mongolian medical warm acupuncture in treating insomnia in combination with the clinical tests, and preliminarily explain the multi-dimension complex mechanism of the Mongolian medical warm acupuncture. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | each day for 2 consecutive days at the 8th day for establishing models of insomnia rats. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | In the model group, the rats were adaptively raised for 7 days and intraperitoneally injected with PCPA (300 mg/kg) in the morning of each day for 2 consecutive days from the 8th day in order to establish insomnia rat models without any other stimuli. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Determination of the differential expression profile of microRNA in the brain tissue of the insomnia rats before and after Mongolian medical warm acupuncture | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The brain tissue of the insomnia rat model and the rats receiving warm acupuncture was collected. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | SYBR ExTaq Mix quantitative PCR amplification was performed for the expression of miR-101a in brain tissue of the warm acupuncture rats, insomnia model rats, and normal control rats. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The brain tissue of rats in the blank control, insomnia model, and warm acupuncture groups were collected, respectively. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Differences in expression of miR-101a in the brain tissue before and after treating the rats for insomnia with Mongolian medical warm acupuncture | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Then, we conducted a fluorescent real-time quantitative PCR study on the levels of miR-101a in 15 insomnia rats receiving warm acupuncture. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Expression of miR-101a in the hippocampus before and after treating the insomnia rats with Mongolian medical warm acupuncture | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | To study the biological functions of miR-101a, fluorescent real-time quantitative PCR was used to detect the expression of miR-101a in the hippocampus before and after treatment of the insomnia rats with Mongolian medical warm acupuncture. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The results indicated that the expression levels of miR-101a in the brain tissue of rats in the insomnia model group decreased significantly compared to that in the brain histiocytes of normal rats (P<0.05). | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The expression of miR-101a in cells transfected with miR-101a mimics at 72 h in the insomnia model group increased significantly (P<0.05) compared to that in the negative control group. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The expression of miR-101a in cells transfected with miR-101a inhibitor at 72 h in the insomnia model group had no significant changes (Fig. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The results of western blotting indicated that the expression of the PAX8 protein in the neuronal cells of the insomnia model rats cultured in vitro with miR-101a mimics added was inhibited and downregulated significantly (P<0.01) compared to the expression of the PAX8 protein in the neuronal cells of the insomnia model rats cultured in vitro with scramble control (Fig. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The levels of interleukins IL-1, IL-2, and IL-6 and TNF-α in the hypothalamus, hippocampus, and prefrontal cortex tissue of the insomnia rats decreased significantly compared with those in the blank control group; differences were significant (P<0.05). | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Results indicate that warm acupuncture had significant efficacy in treatment of insomnia rats. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The detection results indicated that the levels of NE, DA, and Glu of the rats in the insomnia model group were significantly higher than those in the blank control group (P<0.05). | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | After warm acupuncture or treatment with western medicine, the levels of NE, DA, and Glu decreased significantly compared to those in the insomnia model group; differences were statistically significant (P<0.05). | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The levels of 5-HT, GABA, and Ach of the rats in the insomnia model group were significantly lower than those in the blank control group; there was a statistically significant difference (P<0.05). | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The levels of 5-HT, GABA, and Ach of the insomnia rats increased significantly after warm acupuncture or western drug treatment compared to those in the insomnia model group. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | A great deal of clinical research indicates that Mongolian medical warm acupuncture is simple, efficient, and safe in the treatment of insomnia. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Mongolian medicine can improve sleep and treat insomnia by alleviating Heyi, circulating Heyi blood, and balancing Heyi, Xila, and Badagan. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia Circulation | Mechanism |
| 28672928 | It is a good choice for insomnia patients. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | There are many clinical reports on the treatment of insomnia with Mongolian medical warm acupuncture. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The Dinghui Acupoint, Heyi Acupoint, and Qianding Acupoint are largely selected for the treatment of insomnia with acupuncture and satisfactory efficacy is achieved. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | It is thus clear that Mongolian medical warm acupuncture is very efficacious in treating insomnia. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The expression levels of miR-101a in the Mongolian medical warm acupuncture treatment group is increased compared to the insomnia rat model group. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Patients with hypothyroidism are prone to drowsiness and patients with thyroid hyperfunction may suffer from insomnia. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | We discovered that the principle of Mongolian medical warm acupuncture in improving insomnia is directly associated with the role of miR-101a in the regulation of the PAX8 gene. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | In modern medicine, research on insomnia has shown that the sleep-wake up cycle is a physiological process involving coordination and integration of multiple systems and centers with a complex regulatory mechanism. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | Furthermore, we also demonstrated that treating insomnia with Mongolian medical warm acupuncture is also associated with the above neurotransmitters. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | (C and D) A high throughput analysis is conducted for the expression of miRNA in the brain tissue of the insomnia rats receiving Mongolian medical warm acupuncture and the brain tissue of the insomnia rats receiving no treatment with the digital miRNAs expression profile method. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The insomnia rats receiving warm acupuncture and the insomnia rats receiving no warm acupuncture were subjected to determination by qPCR. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | (A) The expression levels of miR-101a in the neurocytes cultured in vitro in the blank control, insomnia model, and warm acupuncture groups are detected with the fluorescent real-time quantitative PCR technique. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | The expression level decreases significantly in the insomnia model group (*P<0.01) and increases significantly in the warm acupuncture group (#P<0.01); (B) the neurocytes of the rats in the three groups cultured in vitro are transfected with miR-101a inhibitor and mimics. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | They exhibit positive and negative dependence expression except for the insomnia model mimics group; (C) the neurocytes of the rats in the warm acupuncture group cultured in vitro show strong viability at 24 h and significant viability at 48 h compared with those in the insomnia model group (*P<0.05); (D) the neurocytes of the rats in the warm acupuncture group cultured in vitro are transfected with the blank plasmid and the miR-101a inhibitor. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | There is a significant difference between the insomnia model and the blank control groups, *P<0.05; #there is a significant difference between the warm acupuncture group and the insomnia model group, *P<0.05. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 28672928 | There is a significant difference between the insomnia model group and blank control group, *P<0.05; #there is a significant difference between the warm acupuncture group, drug treatment group, and the insomniamodel group, *P<0.05. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Insomnia | Mechanism |
| 36636219 | Baihui (DU20), Shenmen (HT7) and Sanyinjiao (SP6) target the cAMP/CREB/BDNF and PI3K/Akt pathways to reduce central nervous system apoptosis in rats with insomnia | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Insomnia can cause damage to function and other medical and mental illnesses, and it is also a risk factor for increasing medical care costs. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | In this study, a model of insomnia was constructed using chlorophenylalanine (PCPA) in 6-week-old male SD rats. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Taken together, these data illustrate the potential of DU20, HT7 and SP6 as a multitargeted therapy for insomnia in rats. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Electroacupuncture; acupoints; rat; insomnia; apoptosis; mechanism. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Insomnia is a common clinical disorder that is characterized by difficulty falling asleep or staying asleep, and it is accompanied by irritability or fatigue when awake. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Insomnia can lead to impaired functioning and other medical and psychiatric disorders, and it is a risk factor that increases healthcare costs. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | The causes of insomnia include genetic, environmental, behavioral, and physiological factors that ultimately lead to hyperexcitability. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Benzodiazepines, nonbenzodiazepines, antidepressants, and melatonin agonists are widely used in the treatment of insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Compared with other treatment methods, the use of acupuncture in traditional therapy is more acceptable, and related studies have also shown that acupuncture can improve insomnia symptoms, sleep time, and daytime function. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Although previous studies have described the mechanisms by which acupuncture regulates immune cytokine production, oxidative defense systems, and neurotransmitters, insomnia involves a variety of complex mechanisms, and further research is needed to improve the acupuncture-insomnia regulatory system. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Immunity Insomnia | Mechanism |
| 36636219 | TCM believes that the brain is the house of the primordial spirit and the point where all yang meets, and the brain is a key organ that regulates insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | On the other hand, TCM believes that the heart controls the gods and is the viscera of insomnia onset. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | In the development of TCM acupuncture, the soothing effect of Shenmen has become the ""first-class main point"" for the treatment of insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Therefore, as an important acupoint for regulating consciousness, Shenmen (HT7) should also be selected to treat insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Therefore, according to the theory of TCM, this study will try to explain the mechanism by which acupuncture functions in the treatment of insomnia by stimulating the three acupoints mentioned above (DU20, HT7, and SP6; referred to as DHS). | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Long-term insomnia increases the incidence of hypertension, coronary heart disease, Alzheimer's disease, anxiety, depression, neurosis, menopausal syndrome, chronic indigestion, anemia, atherosclerosis and other related diseases and seriously affects human lifespan. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia Anxiety Depression | Mechanism |
| 36636219 | People with insomnia are five times more likely to suffer from depression and anxiety than the general population, have a multiplied risk of cardiovascular disease, and have a significantly higher risk of death. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Cardiovascular Insomnia Anxiety Depression | Mechanism |
| 36636219 | The medical resource consumption of insomnia patients is approximately 12 times that of those without insomnia, the incidence of insomnia in females is higher than that in males, and insomnia in females is 1.7 times higher than that in males in people over 45 years old. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Insomnia has multiple regulatory mechanisms. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Because apoptosis is involved in the whole process of insomnia and neuronal death caused by apoptosis is the main pathological feature of familial insomnia, medicinal plants that can regulate apoptosis also have the effect of regulating insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | To further improve the acupuncture-insomnia regulation system. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | The novelty of this study is based on the theory of TCM, the selected acupoints, and the modern systematic research methods, multipathway, multitarget elaboration of the mechanism of electroacupuncture in regulating insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Rat insomnia model and treatment | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Effects of DHS stimulation on the behavior of rats with insomnia | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Evaluation of insomnia models by observing animal behavior has been widely used. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Effects of DHS stimulation on histopathology and the expression of sleep-related factors in rats with insomnia | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Effects of DHS stimulation on histopathology and the expression of sleep-related factors in rats with insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | These results indicate that DHS stimulation can improve neuronal morphology in the hippocampus and brainstem and the levels of sleep-related factors in the serum of rats with insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | These results suggest that DHS stimulation may alleviate the mechanism underlying PCPA-induced insomnia in rats via the cAMP/CREB/BDNF pathway. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | This result indicates that DHS stimulation can effectively inhibit the excitability of the central nervous system and improve the sleep quality of rats with insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia Sleep Quality | Mechanism |
| 36636219 | Insomnia leads to a variety of different behavioral manifestations, including jumping, bumping, irritability, mania, excitement, hair loss, listlessness and other behavioral abnormalities. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | This effect may occur because psychiatric conditions are closely related to sleep disturbances. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Therefore, benzodiazepine receptor agonists and some antidepressants, antihistamines, antipsychotics, and melatonin are often used in the treatment of insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | To elucidate the experimental evidence regarding the use of acupuncture to treat insomnia, this study evaluated the hair, daytime activity, circadian rhythm, aggression, body weight, diet, water intake, and defecation habits of rats with insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | However, we expanded the scope of the treatment of electroacrolescence to insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Studies have shown that during insomnia, accompanied by the activation of small gel cells and hyperplasia and apoptosis of nerve cells, one of the important causes of a large loss of neurons is the large amount of nurnic cell apoptosis. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Although the specific mechanism of apoptosis still needs to be further clarified in the specific mechanism of insomnia, the importance of apoptosis in the insomnia process is self-evident. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | These results all prove that DHS can reduce apoptosis in insomnia rats. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Our research found that DHS can increase the expression of BDNF, which may be another mechanism by which DHS regulates insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Some immune function indicators respond to insomnia and damage immune function. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Immunity Insomnia | Mechanism |
| 36636219 | Other inflammatory reactions, such as IL-10, IL-4, and IL-13, may affect slow wave sleep and even cause insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | Long-term chronic stress can activate the almond core, thereby activating the HPA axis and causing the activation of the HPA axis, and its excessive activation has a close relationship with the development of insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | MT has been used to improve sleep in patients with insomnia primarily because patients who take melatonin do not experience negative effects the next day or exhibit signs of addiction. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | The MT(1) and MT(2) melatonin receptors ramelteon are effective in increasing total sleep time and sleep efficiency, as well as reducing sleep latency, in patients with insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | CORT can induce depression and is involved in the occurrence and development of comorbidities of insomnia, anxiety and depression. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia Anxiety Depression | Mechanism |
| 36636219 | These data provide favorable support for the effectiveness of in regulating insomnia. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | We found that DHS stimulation has a clear effect in improving the characteristics and behavior of rats with insomnia, such as hair, activity, diet, drinking, and defecation. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | DHS can also increase the levels of insomnia IL-1β, PGD2, MT, and IL-10 and reduce the levels of sleep-related factors such as IL-6, TNF-α, IFN-γ, and CORT, and the pathology of rats can also be improved. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 36636219 | In addition, DHS can adjust the apoptotic function of insomnia rats and brain stem tissues through the PI3K/AKT pathway and CAMP/CREB pathway and can also produce benign regulatory effects on mononamine neurotransmitters. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Insomnia | Mechanism |
| 22461840 | Acupuncture, an alternative medicine, has been widely applied for people with sleep disturbances; therefore, the effects should be evaluated objectively. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | Acupuncture was performed at two different points: Dafengmen is located on the head and is an anatomically similar point to human-Baihui (GV20), an effective acupoint for sleep disturbances in humans; pig-Baihui is on the back. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | People with sleep disturbances have increased in developed countries. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | Not only aged people but also working people often show sleep disturbances, causing severe problems in industry. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | Additionally, from the viewpoint of medical economics, the costs of treating sleep disturbances have stressed the government budget, so efficient treatment for sleep disturbance is required. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | Pharmacological drugs involved in serotonin and melatonin metabolism have been applied for people with sleep disturbances; however, the number of people with sleep disturbances has not tended to decrease. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | Acupuncture, an alternative medicine, is believed to relieve sleep disturbances. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | On the other hand, animals do not have information about the procedure; therefore, animal models are beneficial for research into acupuncture for insomnia. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | Acupuncture has been widely applied clinically to people with sleep disturbances; however, there are few objective data. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | Namely, MMPigs are models of sleep disturbance. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 22461840 | In the clinical procedure for patients with sleep disturbances, Baihui is used as the acupuncture point. | Evid Based Complement Alternat Med. 2012;2012:472982. doi: 10.1155/2012/472982. Epub 2012 Feb 16. | Insomnia | Mechanism |
| 37143500 | Other studies have reported adjustment of the primary somatosensory cortex by acupuncture, improvement of colitis by electroacupuncture (EA) treatment of sensitive skin points and acupuncture points, and an insomnia treatment effect of acupuncture. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Insomnia | Mechanism |
| 26654890 | Historically, the point HT7 (Shenmen) has been used to treat irritability, psychosis, epilepsy, poor memory, palpitations, and insomnia. | Acupunct Med. 2016 Jun;34(3):215-22. doi: 10.1136/acupmed-2015-010865. Epub 2015 Dec 9. | Insomnia | Mechanism |
| 37383281 | Acupuncture at Back-Shu point improves insomnia by reducing inflammation and inhibiting the ERK/NF-κB signaling pathway | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia, and long-term use is prone to drug resistance and other adverse reactions. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Adverse Reactions Insomnia | Mechanism |
| 37383281 | Acupuncture has a good curative effect and unique advantages in the treatment of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | We first prepared a rat model of insomnia, and then carried out acupuncture for 7 consecutive days. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippo-campus. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Core Tip: In this study, insomnia was a condition that was unable to maintain a stable sleep state or to sleep. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Western medicine mainly uses sedative and hypnotic drugs to treat insomnia, which easy to produce drug resistance and some adverse reactions. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Adverse Reactions Insomnia | Mechanism |
| 37383281 | Acupuncture has excellent efficacy and unique advantages in the treatment of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | This study aimed to investigate the molecular mechanism of Back-Shu acupuncture for insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Insomnia is a common clinical disease. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Sleeping difficulty and short sleep time are typical clinical symptoms of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Insomnia not only seriously affects patients' daily activities and work, but also leads to a reduction in their living standards. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | At present, sedatives, hypnotics, antidepressants, and other psychiatric drugs are mainly used to treat insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Traditional Chinese medicine believes that insomnia is a type of restlessness caused by liver qi stagnation and spleen damage. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | The pathogenesis of insomnia is still unclear and may be related to the dysfunction of neurotransmitters, inflammatory cytokines, neuroendocrine factors, melatonin, signal transduction pathways, neurotrophic factors, and intestinal flora in the brain. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | It plays an essential regulatory role in tumor pathogenesis, various inflammatory diseases, mental disorders, insomnia, and other diseases. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | The ERK signaling pathway can be activated after receiving stimulation signals, which activates the downstream transcription factor NF-κB, affects the secretion of inflammatory cytokines [interleukin (1L)-1β, 1L-6, tumor necrosis factor (TNF)-α], and induces functional changes, thereby leading to insomnia and increasing the risk of chronic inflammatory diseases. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Clinical studies have found that acupuncture at Back-Shu point has an excellent therapeutic effect on insomnia, effectively improving depression, anxiety, memory loss, immunity decline and other clinical symptoms caused by insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Immunity Insomnia Anxiety Depression | Mechanism |
| 37383281 | Experimental studies have confirmed that the pathogenesis of insomnia is closely related to the ERK/NF-κB signaling pathway. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | We hypothesize that inhibition of ERK/NF-κB signaling pathway activation may be a potential target in the treatment of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | In this study, a rat model of insomnia was established by intraperitoneal injection of p-chlorophenylalanine (PCPA). | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | The secretion levels of proinflammatory cytokines such as IL-1β, IL-6 and TNF-α in serum and the hippocampus, and the protein expression of ERK/NF-κB signaling pathway markers were detected to verify whether acupuncture at Back-Shu point could inhibit the ERK/NF-κB signaling pathway to relieve insomnia, providing new insights for the clinical treatment of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Evaluation of the insomnia model | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | PCPA was injected intraperitoneally in rats to construct an insomnia model. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Compared with the Con group, the sleep latency of rats in the Model group was prolonged and the sleep time was shortened, indicating that the insomnia rat model was successfully established (Figure 1). | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | In conclusion, acupuncture at Back-Shu acupoints improved cognitive behavioral changes and emotional disturbances caused by insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia Mood | Mechanism |
| 37383281 | Effects of acupuncture at Back-Shu point on the behavior of insomnia rats | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Acupuncture at Back-Shu point increased inflammation in insomnia rats | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Abnormal secretion of inflammatory cytokines can cause sleep-wake cycle disorder and lead to insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | In conclusion, we believe that acupuncture at Back-Shu point can improve insomnia in rats by inhibiting the ERK/NF-κB signaling pathway. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Insomnia is a common disease that not only reduces patients' life quality, but also causes other physical diseases, significantly impacting patients' lives. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Due to their reproductive ability, easy feeding, easy modeling and experimental operation, and similar sleep-wake cycle and biological regulatory function to humans, rats were selected to construct the insomnia model in this study. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | After intraperitoneal injection of PCPA in rats for three consecutive days, the rats showed circadian rhythm disorder, frequent daytime activity, wet and dark hair, increased aggression during stimulation, and mutual fighting and biting behaviors, which lasted for one week, which was consistent with the clinical symptoms caused by insomnia, indicating that the insomnia model was successfully established. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | In traditional Chinese medicine, insomnia belongs to the category of ""sleepless"" and the Back-Shu point is the acupoint on the bladder meridian, which is closely related to the brain. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Currently, the five acupoints most commonly used in treating insomnia by acupuncture at Back-Shu point are Xin Yu, Gan Yu, PI Yu, Fei Yu, and Shen Yu. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | In conclusion, the results show that acupuncture at the Back-Shu point can improve the cognitive behavior changes and emotional disorders caused by insomnia, improve learning and memory ability in rats, and promote learning and memory function recovery. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia Learning and Memory Ability Mood | Mechanism |
| 37383281 | Activation of the immune system will change the sleep state, which can lead to increased sleep duration, and lead to the occurrence of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Immunity Insomnia | Mechanism |
| 37383281 | Cytokines in the sleep-wake cycle and immune system mediate between signals, and through the receptor act on the peripheral nervous system or the central nervous system neurons, astrocytes and microglia, through afferent nerve fibers and blood to the brain signals, cause inflammation and then insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Immunity Insomnia | Mechanism |
| 37383281 | The results of the present study showed that compared with the Con group, the proinflammatory cytokines, IL-6, 1L-1β and TNF-α in the Model group rats' serum and hippocampus were significantly decreased (P < 0.01), suggesting that insomnia can result in a proinflammatory cytokine secretion imbalance, affect the body's immune system, resulting in sleep cycle disorder, consistent with previous research results. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Immunity Insomnia | Mechanism |
| 37383281 | Compared with the Model group, the secretion of IL-1β, IL-6 and TNF-α in the Acupuncture group and U0126 group were significantly increased, suggesting that acupuncture at Back-Shu point may participate in the regulation of sleep and the immune system, improve the secretion of proinflammatory cytokines, maintain the balance of cytokines, and promote recovery of the body's immune system and the improvement of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Immunity Insomnia | Mechanism |
| 37383281 | RAF-1, MEK-2, ERK1/2 and NF-κB are essential targets in the RAF-MEK-ERK-NF-κB pathway, which regulate cell proliferation, apoptosis, differentiation and other physiological activities, and participate in the pathogenesis and clinical symptoms of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | This study showed that compared with the Con group, the mRNA and protein expression levels of RAF-1, MEK-2, ERK1/2 and NF-κB in the hippocampus of the Model group were significantly increased (P < 0.01), and the number of positive cells increased, suggesting that the pathogenesis of insomnia may be related to activation of the ERK/NF-κB pathway. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | To further investigate whether acupuncture at the Back-Shu point improves insomnia by inhibiting the ERK/NF-κB signaling pathway, U0126 was injected into the tail vein of rats. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | We believe that the pathogenesis of insomnia may be related to activation of the ERK/NF-κB signaling pathway. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Thus, acupuncture may promote the body's immune system recovery and play a role in the treatment of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Immunity Insomnia | Mechanism |
| 37383281 | The characteristics of insomnia are dissatisfaction with sleep, including difficulty beginning or maintaining sleep, waking up with/or early morning, accompanied by related daytime damage, such as fatigue and emotional disorders. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia Mood | Mechanism |
| 37383281 | Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia, and long-term use is prone to drug resistance and other adverse reactions. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Adverse Reactions Insomnia | Mechanism |
| 37383281 | Acupuncture has a good curative effect and unique advantages in the treatment of insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | To explore the molecular mechanism of acupuncture at Back-Shu point for insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | To provides a new insight into the treatment of insomnia by acupuncture at Back-Shu point from the perspective of traditional Chinese medicine. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | We first prepared a rat model of insomnia, and then carried out acupuncture for 7 consecutive days to explored the effect of acupuncture. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Some Western drugs can improve insomnia symptoms, but their high drug dependence and adverse reactions limit their clinical application. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Adverse Reactions Insomnia | Mechanism |
| 37383281 | Our study provides new insights into the treatment of insomnia symptoms from the perspective of traditional Chinese medicine. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Our study fills a gap in the treatment of insomnia with acupuncture at Back-Shu point and provides a new treatment for insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | This study suggest that acupuncture at the Back-Shu point can improve the insomnia by inhibiting the ERK/NF-κB signaling pathway and increasing the release of inflammatory cytokines in the hippo-campus. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | Acupuncture at the Back-Shu point has promoted the treatment of insomnia and benefited the public's sleep health. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 37383281 | This paper provides new ideas for the treatment of insomnia from the perspective of acupuncture. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia | Mechanism |
| 31312613 | In recent years, acupuncture has been widely used among cancer patients as a none-drug therapy against many cancer-related symptoms including cancer-related pain, vomiting, postoperative intestinal obstruction, dry mouth, fatigue, hot flashes, anxiety, insomnia and others. | Front Oncol. 2019 Jul 2;9:576. doi: 10.3389/fonc.2019.00576. eCollection 2019. | Insomnia Nausea and Vomiting Anxiety | Mechanism |
| 31322212 | For example, fatigue can be improved by massaging Yanglingchuan (GB34), Sanyinjiao (SP6) and Zusanli; sleep disturbances can be treated by Hand Shenmen (HT7) and Ear Shenmen (MATF1); acupuncture or acupressure on Hegu (LI4) can relieve pain and exert anti-inflammatory effects; acupuncture on Taixi (KI3) can relieve renal disease, cognitive disorders and impotence. | Mol Med Rep. 2019 Sep;20(3):2267-2275. doi: 10.3892/mmr.2019.10470. Epub 2019 Jul 4. | Insomnia Kidney | Mechanism |
| 21799673 | The Sanyinjiao or SP6 (Spleen 6) acupoint is a spot in the spleen channel that also functions as an important, general tonification point indicated in many disorders, including gynecological, genitourinary, allergic, insomnia, immunological and psychosomatic diseases and pain control. | Evid Based Complement Alternat Med. 2011;2011:217946. doi: 10.1093/ecam/neq036. Epub 2011 Jun 5. | Immunity Insomnia | Mechanism |
| 27381504 | Moreover, this chronic pain is associated with fatigue, depression, memory problems, anxiety, sleep disturbances, and headaches. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Insomnia Anxiety Depression | Mechanism |
| 27381504 | Pregabalin is a presynaptic voltage-gated calcium channel blocker that is used to reduce FM-related pain and sleep disturbances. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Insomnia | Mechanism |
| 37384285 | Warm needle acupuncture has been reported to be effective in the treatment of various diseases and disorders, such as rheumatoid diseases, musculoskeletal disorders, and insomnia, although the underlying mechanisms remain to be identified. | Front Neurol. 2023 Jun 13;14:1168012. doi: 10.3389/fneur.2023.1168012. eCollection 2023. | Insomnia | Mechanism |
| 38164490 | Chronic extensive pain is the main syndrome upsetting individuals with fibromyalgia (FM), accompanied by anxiety, obesity, sleep disturbances, and depression, Transient receptor potential vanilloid 1 (TRPV1) has been reported to transduce inflammatory and pain signals to the brain. | Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. | Insomnia Anxiety Depression Inflammatory Pain | Mechanism |
| 38164490 | The beneficial effects of acupuncture in FM extend to its capacity to diminish anxiety, depression, and sleep disturbance. | Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. | Insomnia Anxiety Depression | Mechanism |
| 38164490 | ACE is broadly utilized in the hospital for weight control, insomnia, pain treatment, and osteoarthritis. | Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. | Insomnia | Mechanism |
| 35478723 | In addition, the patients with cervical spondylosis show mental tension, anxiety, and insomnia. | Front Surg. 2022 Apr 11;9:778608. doi: 10.3389/fsurg.2022.778608. eCollection 2022. | Insomnia Anxiety | Mechanism |