- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Modulation
- Immunity
- Acupuncture anesthesia may enhance the body's immune response, reducing the risk of postoperative infections.
- Blood Flow
- Acupuncture anesthesia can optimize blood flow to tissues, aiding in wound healing and tissue recovery.
- Endocrinology
- Acupuncture anesthesia can influence endocrine function, helping maintain hormonal balance during surgery.
- Circulation
- Acupuncture anesthesia supports overall circulatory health, ensuring adequate oxygen and nutrient delivery to tissues.
- Microcirculation
- Acupuncture anesthesia positively affects microcirculation, benefiting tissue perfusion and healing.
- Blood Pressure
- Acupuncture anesthesia can help stabilize blood pressure, reducing perioperative hypertension risks.
- Heart Rate
- Acupuncture anesthesia can regulate heart rate, promoting cardiovascular stability during surgery.
- Hemodynamics
- Acupuncture anesthesia optimizes hemodynamic parameters, contributing to surgical safety.
- Bleeding
- Acupuncture anesthesia may reduce intraoperative bleeding, enhancing surgical outcomes.
- Skin Temperature
- Acupuncture anesthesia can help maintain stable skin temperature during surgery, preventing hypothermia.
Acupuncture anesthesia for Modulation-Microcirculation
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 17206916 | Bioengineering assessment of acupuncture, part 2: monitoring of microcirculation. | Crit Rev Biomed Eng. 2006;34(4):273-94. doi: 10.1615/critrevbiomedeng.v34.i4.10. | Microcirculation | Review |
| 17206916 | In the second part of the review article, monitoring of microcirculation during acupuncture is described. | Crit Rev Biomed Eng. 2006;34(4):273-94. doi: 10.1615/critrevbiomedeng.v34.i4.10. | Microcirculation | Review |
| 17206916 | Using these types of biomedical equipment, it is possible to quantify and objectify peripheral changes in microcirculation during different methods of acupuncture stimulation (manual needle acupuncture and laserneedle acupuncture). | Crit Rev Biomed Eng. 2006;34(4):273-94. doi: 10.1615/critrevbiomedeng.v34.i4.10. | Microcirculation | Review |
| 17907396 | In the present paper, the authors review the current development of studies on mechanisms of acupuncture treatment of acute ischemic cerebral apoplexy from (1) blood rheology, (2) cerebral microcirculation, 3) metabolism of cerebral tissue, (4) cerebral electrical activity, (5) free radicals and lipid peroxidation reaction, (6) excitatory aminoacid, (7) calcium overload, (8) nitrogen monoxidum, and (9) cerebral apoptosis. | Zhen Ci Yan Jiu. 2007 Aug;32(4):285-8. | Microcirculation | Review |
| 21090338 | In the present paper, the authors review recent development of experimental researches on the mechanism underlying acupuncture-induced improvement of migraine from: 1) inhibiting neurogenic inflammation, 2) improving cerebro-microcirculation, and 3) regulating vasoactive substances. | Zhen Ci Yan Jiu. 2010 Aug;35(4):315-8. | Microcirculation | Review |
| 24215922 | Series of clinical trials have shown that acupuncture primarily regulates the release of neurochemicals, hemorheology, cerebral microcirculation, metabolism, neuronal activity, and the function of specific brain region. | Int Rev Neurobiol. 2013;111:159-79. doi: 10.1016/B978-0-12-411545-3.00008-0. | Microcirculation | Review |
| 25854040 | Development on research of acupuncture effects on microcirculation. | Zhongguo Zhen Jiu. 2015 Feb;35(2):203-8. | Microcirculation | Review |
| 25854040 | The Chinese and English published literature regarding the effects of acupuncture on microcirculation in recent years were analyzed, and it was found out that the theory of TCM meridian had subtle connection with microcirculation on structure and function, which could provide a possible breakthrough for the research of meridian essence. | Zhongguo Zhen Jiu. 2015 Feb;35(2):203-8. | Microcirculation | Review |
| 25854040 | Acupuncture, through multiple links, multiple paths and multiple levels, could regulate microcirculation under physiological or pathological condition, which was a bidirectional benign adjustment function, and reflected the characteristic of acupoint specificity. | Zhongguo Zhen Jiu. 2015 Feb;35(2):203-8. | Microcirculation | Review |
| 8073239 | To establish responders and non-responders, lung function tests and measurement of microcirculation and skin temperature are carried out before and after acupuncture treatment. | Schweiz Med Wochenschr Suppl. 1994;62:39-48. | Microcirculation Skin Temperature | Review |
| 24809037 | Moreover, acupuncture have been shown to increase glucose uptake and microcirculation. | Transl Med UniSa. 2014 Apr 24;9:56-65. eCollection 2014 Apr. | Microcirculation | Review |
| 26221180 | The Effects of Acupuncture on Cerebral and Muscular Microcirculation: A Systematic Review of Near-Infrared Spectroscopy Studies | Evid Based Complement Alternat Med. 2015;2015:839470. doi: 10.1155/2015/839470. Epub 2015 Jun 11. | Microcirculation | Review |
| 26221180 | We review the literature investigating the effect of acupuncture on muscular and/or cerebral microcirculation. | Evid Based Complement Alternat Med. 2015;2015:839470. doi: 10.1155/2015/839470. Epub 2015 Jun 11. | Microcirculation | Review |
| 27403201 | Studies demonstrating any type of microcirculation response to manual acupuncture in healthy subjects and patients were included. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | Of the seven studies in healthy subjects, four reported significant increases in blood flow following acupuncture compared with control, whereas one other study observed reductions in microcirculation immediately after acupuncture needling. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation Blood Flow | Review |
| 27403201 | Microcirculation is affected by the autonomic nervous system (ANS) and is regarded as a useful method with which to evaluate the peripheral effects of acupuncture. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | Thus, the primary aims of the present review were to summarize and evaluate the effects of acupuncture on local microcirculation and to compare the blood flow changes induced by acupuncture among five types of typical control groups: no-acupuncture, nonpenetrating acupuncture at same acupoint, superficial acupuncture, acupuncture needling at a nonacupoint, and insertion-only without manipulation. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation Blood Flow | Review |
| 27403201 | In the studies that assessed patients with fibromyalgia and trapezius myalgia, the sensitivity of microcirculation to acupuncture needling varied according to patient characteristics. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | The subsequent study from this group revealed that acupuncture performed at GB21 (on the back of the shoulder located on the trapezius muscle), where the trapezius myalgia and fibromyalgia patients suffered pain, produced different patterns of microcirculation. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | reported a transient reduction in skin microcirculation following acupuncture at a nearby fingertip and the transient effects of acupuncture stimulation on transient sympathetic activation. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | In the two studies of patients with fibromyalgia or trapezius myalgia, there were significant increases in blood flow in the skin and muscle, but the sensitivity of microcirculation to the acupuncture needling varied depending on the characteristics of disease. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation Blood Flow | Review |
| 27403201 | Clinical Aspects of Microcirculation Measures: Differences between Healthy Subjects and Patients in Microcirculation Changes after Acupuncture | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | studied whether acupuncture-induced changes in local microcirculation could have a clinical influence and found that the repeated manipulation of LI4 enhanced local microcirculation and increased the analgesic effects compared with single manipulations or insertion-only. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Analgesic Effect Microcirculation | Review |
| 27403201 | Additionally, these two parameters were correlated, which indicates that local increases in microcirculation might influence the analgesic effects of acupuncture. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Analgesic Effect Microcirculation | Review |
| 27403201 | reported a reduction in skin microcirculation immediately following acupuncture treatment. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | also reported that acupuncture induced an immediate reduction in microcirculation that returned to normal levels within 1 minute. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | The studies selected for the present review propose several possible mechanisms that may underlie the changes in microcirculation following acupuncture treatment. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 27403201 | It suggested here that the increased blood perfusion induced by acupuncture stimulation might be relevant to the suppression of the sympathetic nerve activity and the vasodilation in local microvascular beds. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Microcirculation | Review |
| 28933377 | A schematic diagram of the relationship between acupuncture stimulation, changes of microcirculation and mast cells is presented as result. | Medicines (Basel). 2014 Nov 20;1(1):56-63. doi: 10.3390/medicines1010056. | Microcirculation | Review |
| 28933377 | In the research area of microcirculation, laser Doppler flowmetry (LDF) is widely being used for monitoring the microcirculation due to its advantage of a good frequency response, and is therefore well suited for noninvasive investigations of microvascular responses to acupuncture. | Medicines (Basel). 2014 Nov 20;1(1):56-63. doi: 10.3390/medicines1010056. | Microcirculation | Review |
| 28933377 | It has also been shown that acupuncture cannot only increase general circulation and circulation in specific organs, but it can also change the skin microcirculation as well. | Medicines (Basel). 2014 Nov 20;1(1):56-63. doi: 10.3390/medicines1010056. | Microcirculation Circulation | Review |
| 28933377 | Previous results indicated that acupuncture can regulate microcirculation. | Medicines (Basel). 2014 Nov 20;1(1):56-63. doi: 10.3390/medicines1010056. | Microcirculation | Review |
| 28933377 | Block diagram of the relationship between acupuncture stimulation, changes of microcirculation, and mast cells. | Medicines (Basel). 2014 Nov 20;1(1):56-63. doi: 10.3390/medicines1010056. | Microcirculation | Review |
| 30854010 | After acupuncture treatment, the active component such as 5-Hydroxytryptamine (5-HT) and Histamine (HB) in the gastrointestinal microcirculation decreased in obese patients, while prostaglandin E2(PGE2) increased on the effected side. | Evid Based Complement Alternat Med. 2019 Feb 3;2019:5796381. doi: 10.1155/2019/5796381. eCollection 2019. | Microcirculation Side Effects | Review |
| 30984420 | Studies have reported that acupuncture can improve cerebral blood flow and increase microvascular openings in the hippocampus CA1 area by increasing the proportion of Bcl-2/Bax and inhibiting apoptosis, in order to lower BP and prevent target organ damage. | Int J Hypertens. 2019 Mar 7;2019:8676490. doi: 10.1155/2019/8676490. eCollection 2019. | Microcirculation Blood Pressure Blood Flow | Review |
| 31467579 | Current research shows that acupuncture has a definite curative effect on the treatment of cerebral ischemia-reperfusion injury, and it plays an important role in improving microcirculation, improving brain electrical activity, and inhibiting oxygen-free radicals, thereby greatly reducing nerve injury. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Microcirculation | Review |
| 32215037 | Acupuncture therapies were reported significantly decreasing intestinal microvascular permeability and improving microcirculation, protecting intestinal epithelial cells from inflammatory response in sepsis. | Evid Based Complement Alternat Med. 2020 Mar 7;2020:3620741. doi: 10.1155/2020/3620741. eCollection 2020. | Microcirculation | Review |
| 34992414 | Several lines of evidence have confirmed that acupuncture effectively treats circulatory system diseases and adjusts the levels of a variety of chemical components, such as plasma proteins, blood ammonia, electrolytes, enzyme activities, and other biological active substances to regulate vascular function, promote the formation of collateral neovascularization, improve the microcirculation, and enhance the remodeling of ventricular function. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Microcirculation Circulation | Review |
| 35241146 | Acupuncture has been shown to increase CBF and improve microcirculation, which could potentially explain the beneficial effects of acupuncture on treating cerebral ischemia. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Microcirculation | Review |
| 35241146 | Both animal and clinical studies have proved that acupuncture can increase the cerebral blood flow and cerebral microcirculation by regulating the expression of angiogenesis-related factors, which result in a more conducive microenvironment for the survival of transplanted stem cells and the regeneration of NVUs at the infarct site. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Microcirculation Blood Flow | Review |
| 35462893 | Acupuncture-induced neuroprotection includes several mechanisms such as reducing oxidative stress, inhibiting the inflammatory response and neuronal apoptosis, alleviating glial scar formation, promoting neural stem cell differentiation, and improving microcirculation within the injured area. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuroprotection Microcirculation | Review |
| 35462893 | Clinical studies conducted in healthy adults demonstrated that acupuncture influences the tortuousness of capillary loops, the diameter of the afferent loop, and capillary refill time, thereby regulating the microcirculation. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Microcirculation | Review |
| 35462893 | In addition, a study using the intervertebral disc extrusion model revealed that electroacupuncture improves microcirculation characterized by high blood flow, micro-vessel density, and reduced vacuolation within the white matter. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Microcirculation Blood Flow | Review |
| 35462893 | Acupuncture can also regulate microcirculation and attenuate neurological dysfunction by suppressing the cPLA2 activity and PGE2 level. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Microcirculation | Review |
| 35462893 | We explained in detail the underlying mechanisms of acupuncture therapy for SCI, including oxidative stress reduction, inflammation and apoptosis inhibition, microcirculation improvement, glial scar formation reduction, and stimulation of NSC differentiation (Figure 1). | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Microcirculation | Review |
| 35462893 | Illustration of the possible mechanism underlying acupuncture therapy in SCI, including oxidative stress reduction, inflammation and apoptosis inhibition, microcirculation improvement, reduction of glial scar formation, and stimulation of NSC differentiation and proliferation. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Microcirculation | Review |
| 35737304 | Physiologically, all acupuncture points share the same effects including fibroblast mechanotransduction, fascial interaction, neuromodulation leading to analgesia, fluid motion modulation and the manipulation of the microvascular environment.. Some points may specifically cause immune modulation, affect the autonomic nervous system, visceral organs, or the brain, modulate lymphatic flow or cause neuromuscular effects. | Vet Sci. 2022 May 26;9(6):252. doi: 10.3390/vetsci9060252. | Immunity Microcirculation | Review |
| 36388196 | Acupuncture modulates microcirculation | Front Neurol. 2022 Oct 28;13:1030747. doi: 10.3389/fneur.2022.1030747. eCollection 2022. | Microcirculation | Review |
| 36388196 | Furthermore, acupuncture effectively dilated the diameter of microvessels and augmented the blood flow of the leptomeningeal microcirculation (Table 4). | Front Neurol. 2022 Oct 28;13:1030747. doi: 10.3389/fneur.2022.1030747. eCollection 2022. | Microcirculation Blood Flow | Review |
| 36388196 | Therefore, it is reasonable to infer that acupuncture may enhance microcirculation through the regulation of key enzymes in cell metabolism, thereby improving neurological function prognosis in ischemic stroke. | Front Neurol. 2022 Oct 28;13:1030747. doi: 10.3389/fneur.2022.1030747. eCollection 2022. | Microcirculation | Review |
| 36388196 | In the meantime, acupuncture improved microcirculation, enhancing energy metabolism of brain tissues and ameliorating neurological function prognosis (Figure 6). | Front Neurol. 2022 Oct 28;13:1030747. doi: 10.3389/fneur.2022.1030747. eCollection 2022. | Microcirculation | Review |
| 38189090 | First, promoting blood circulation: acupuncture can stimulate the nerves and tissues around acupoints, thus increasing blood flow and microcirculation, which helps to improve the blood supply to the kidneys. | Ren Fail. 2024 Dec;46(1):2301504. doi: 10.1080/0886022X.2023.2301504. Epub 2024 Jan 8. | Microcirculation Circulation Blood Flow | Review |
| 29391879 | Furthermore, acupuncture combined with drugs can effectively suppress the central nervous system, improve microcirculation and oxygen metabolism of brain tissues, increase cerebral blood supply, relieve cerebral edema, and reduce inflammatory responses in the hippocampus caused by inflammatory factors crossing the blood-brain barrier. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Microcirculation | Clinic |
| 23573118 | According to a well-known part of classical Chinese medical theoryxe2x80x94the Shang Han Lunxe2x80x94which is systematized in the xe2x80x9cAlgor Laedens Theoryxe2x80x9d of the xe2x80x9cHeidelberg model of TCMxe2x80x9d, severe postoperative pain arises from xe2x80x9cxue stasisxe2x80x9d (relative hypoxis of a tissue arising from a disrupted microcirculation) due to xe2x80x9cpost-traumatic algorxe2x80x9d (reduced microcirculation of a tissue following a trauma due to vasospasmic reflexes and immunological reactions). | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Immunity Microcirculation | Clinic |
| 25185370 | Effect of zusanli (ST 36) moxibustion on rat mesenteric microvascular system. | J Tradit Chin Med. 2014 Aug;34(4):491-7. doi: 10.1016/s0254-6272(15)30052-2. | Microcirculation | Mechanism |
| 25185370 | We continuously monitored mesenteric microvascular changes with in vivo microscopic video. | J Tradit Chin Med. 2014 Aug;34(4):491-7. doi: 10.1016/s0254-6272(15)30052-2. | Microcirculation | Mechanism |
| 19151301 | BACKGROUND: Acupuncture stimulation and phototherapy have been reported to have analgesic effects and improve the microcirculation. | Anesth Analg. 2009 Feb;108(2):635-40. doi: 10.1213/ane.0b013e31819317bc. | Analgesic Effect Microcirculation | Mechanism |
| 19151301 | Acupuncture stimulation and phototherapy, associated with minimal systemic and local side effects, can enhance the microcirculation and may be a useful supportive treatment for diseases caused by poor peripheral blood flow. | Anesth Analg. 2009 Feb;108(2):635-40. doi: 10.1213/ane.0b013e31819317bc. | Microcirculation Side Effects Blood Flow | Mechanism |
| 2883836 | Effects of acupuncture needle application upon cutaneous microcirculation of rabbit ear lobe. | Acupunct Electrother Res. 1987;12(1):45-51. doi: 10.3727/036012987816951121. | Microcirculation | Mechanism |
| 2883836 | Although no striking findings were obtained during the needle application for a period of 30 minutes, it was clearly observed that the microvascular blood flow increases gradually in parallel with augmenting spontaneous rhythmic fluctuation of the vessel diameter, namely vasomotion, throughout a continuous observation period longer than 2 hours following release from the needle application. | Acupunct Electrother Res. 1987;12(1):45-51. doi: 10.3727/036012987816951121. | Microcirculation Blood Flow | Mechanism |
| 2883836 | The clinical efficacy of acupuncture was suggested to be explained at least in part by the increased rhythmic microvascular blood flow in parallel with vasomotion, from the physiological point of view based on the previous investigations. | Acupunct Electrother Res. 1987;12(1):45-51. doi: 10.3727/036012987816951121. | Microcirculation Blood Flow | Mechanism |
| 24170631 | Indices of neurobehavioral scores, cerebral blood flow, infarction rate, microcirculation, and light microscope, etc. | Chin J Integr Med. 2013 Nov;19(11):853-8. doi: 10.1007/s11655-013-1530-7. Epub 2013 Oct 30. | Microcirculation Blood Flow | Mechanism |
| 24619238 | Neurobehavioral scores, cerebral blood flow, infarction rate, microcirculation, light microscopy, etc. | Chin J Integr Med. 2014 Feb;20(2):130-5. doi: 10.1007/s11655-013-1584-6. Epub 2014 Mar 6. | Microcirculation Blood Flow | Mechanism |
| 635615 | Possible mechanisms to explain alleged acupuncture-induced arousal may include vasodilatory effects caused by smypathetic stimulation which leads to an augmentation of cerebral microcirculation and thereby improves oxygen supply to the brain tissue. | South Med J. 1978 Apr;71(4):392-5, 398. doi: 10.1097/00007611-197804000-00015. | Microcirculation | Mechanism |
| 608334 | Possible mechanisms to explain alleged acupuncture-induced arousal may include vasodilatory effects caused by sympathetic stimulation which leads to an augmentation of cerebral microcirculation and thereby improves oxygen supply to the brain tissue. | Comp Med East West. 1977 Summer;5(2):147-54. doi: 10.1142/s0147291777000210. | Microcirculation | Mechanism |
| 35216533 | Here, the efficacy of electroacupuncture (EA) with respect to regulation of microvascular remodeling induced by VEGF/PI3K/Akt was evaluated in a rat model of COPD. | Acupunct Med. 2022 Aug;40(4):389-400. doi: 10.1177/09645284221078873. Epub 2022 Feb 25. | Microcirculation | Mechanism |
| 30883553 | Moreover, the modulation of the immune system and microcirculation are also considered important effects in acupoint activation and acupuncture mechanisms. | PLoS One. 2019 Mar 18;14(3):e0211341. doi: 10.1371/journal.pone.0211341. eCollection 2019. | Immunity Microcirculation | Mechanism |
| 30883553 | Previous results indicated the mean blood flow was larger at the acupoints than in their surrounding tissues, indicating when an acupoint was stimulated adequately, the blood perfusion of this point continued to increase and improve local microcirculation in specific organs and tissues. | PLoS One. 2019 Mar 18;14(3):e0211341. doi: 10.1371/journal.pone.0211341. eCollection 2019. | Microcirculation Blood Flow | Mechanism |
| 30883553 | This is probably because LA can promote local microcirculation to increase waste removal and adequate nutrient delivery to chondrocytes. | PLoS One. 2019 Mar 18;14(3):e0211341. doi: 10.1371/journal.pone.0211341. eCollection 2019. | Microcirculation | Mechanism |
| 30740905 | We proposed that acupoint sensitization may not be associated with the structural changes in microcirculation and that the microcirculatory changes during acupoint sensitization are more likely to be functional. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | Therefore, the structural changes and functional characteristics of microcirculation during acupoint sensitization need to be clarified to improve diagnostic and treatment capabilities, as well as better understand of acupoint connotation. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | Microcirculation plays a pivotal role in metabolic supply and metabolism, regulating blood flow and maintaining homeostasis. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation Blood Flow | Mechanism |
| 30740905 | Local microcirculation has been identified as an important target of acupuncture and is closely associated with the acupuncture effects 11. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | However, the structural and functional characteristics of microcirculation during the sensitization have been neglected to some extent. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | In the present study, we aimed to characterize the structural changes in microcirculation at several acupoints such as Yanglingquan (GB34) and Zusanli (ST36) by using PAI. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | Our findings can be added to the debate on the microcirculatory characteristics of sensitized acupoints and support the negative structural changes in microcirculation during acupoint sensitization. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | Quantitative analysis of microvascular morphological parameters | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | A dedicated microvascular quantification algorithm, as described previously 20, 28, was used to quantitatively analyze the changes in microcirculatory structure at the GB34, ST36 and nonacupoint sites. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | No significant differences in the microvascular changes of the GB34, ST36 and nonacupoint sites were found on days 0, 7 and 21 among the N, NS and OA groups. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | These two acupoints were selected as the target acupoints in this study to better clarify the structural changes of microcirculation during acupoint sensitization. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | Based on these findings, we hypothesized that acupoint sensitization primarily contribute to the functional changes in microcirculation. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | Moreover, it was speculated that the acupoint sensitization on microcirculation is more likely to be functional and thus displays a functional characteristic. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | The functional changes in the microcirculation during acupoint sensitization such as hemoglobin oxygen saturation, blood flow and rate of oxygen metabolism should be investigated. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation Blood Flow | Mechanism |
| 30740905 | To the best of our knowledge, this study is the first time that acupoint sensitization in knee OA has been shown to have no association with the structural changes in microcirculation, suggesting that microcirculatory changes during acupoint sensitization are more likely to be functional. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | It is suggested that the structural changes in microcirculation lag behind functional changes and are closely associated with disease severity. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | In an experimental knee OA mouse model, structural changes in the microcirculation were dynamically observed during acupoint sensitization. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | This study preliminarily confirmed that acupoint sensitization in knee OA is not associated with structural changes in microcirculation at the ST36, GB34 and nonacupoints sites. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation | Mechanism |
| 30740905 | Further research should focus on the functional changes in the microcirculation during acupoint sensitization such as hemoglobin oxygen saturation, blood flow and rate of oxygen metabolism. | J Biophotonics. 2019 Jun;12(6):e201800458. doi: 10.1002/jbio.201800458. Epub 2019 Mar 6. | Microcirculation Blood Flow | Mechanism |
| 21796340 | A second cell model was murine microvascular endothelial cell line H5V. | Pflugers Arch. 2011 Oct;462(4):587-97. doi: 10.1007/s00424-011-0993-7. Epub 2011 Jul 28. | Microcirculation | Mechanism |
| 29123119 | CGRP released by activation of small fibre sensory nerve terminals causes neurogenic inflammation in the skin by activating vasodilation, axon reflex flare, and microvascular plasma extravasation. | Sci Rep. 2017 Nov 9;7(1):15214. doi: 10.1038/s41598-017-14359-z. | Microcirculation | Mechanism |
| 24722278 | Past records indicate that needling at Neiguan (PC6) acupoint exerts cardioprotective effects on several kinds of ischemic heart injuries, including cardiac surgery, myocardial ischemia-reperfusion, and acute myocardial ischemia by improving hemodynamics, microcirculation and energy metabolism, as well as decreasing susceptibility to ventricular tachycardia. | PLoS One. 2014 Apr 10;9(4):e94604. doi: 10.1371/journal.pone.0094604. eCollection 2014. | Microcirculation Hemodynamics | Mechanism |
| 32956833 | Due in part to its broad anatomical distribution, the SP/NK1R system is involved in a variety of complex physiological responses, including neuroinflammation, microvascular permeability, and pain. | Brain Behav Immun. 2021 Jan;91:683-694. doi: 10.1016/j.bbi.2020.08.016. Epub 2020 Sep 18. | Microcirculation | Mechanism |
| 32956833 | These neuropeptides play a role in neurogenic inflammation in the skin by activating vasodilation, axon reflex flare, and microvascular plasma extravasation. | Brain Behav Immun. 2021 Jan;91:683-694. doi: 10.1016/j.bbi.2020.08.016. Epub 2020 Sep 18. | Microcirculation | Mechanism |
| 38026466 | In the future, it will be necessary to test the therapeutic effect of IQAB using a larger sample size, different CSR stages, and detection indicators that better reflect the state of Qi and Blood such as microcirculation and motor scores. | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Microcirculation | Mechanism |
| 25206406 | The far-end of the internal carotid artery was blocked with a microvascular clip. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Microcirculation | Mechanism |
| 25206406 | The silk suture around the internal carotid artery was tightened and the microvascular clip was removed. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Microcirculation | Mechanism |
| 24803946 | In addition to the damage at the site of the spinal cord injury, secondary pathological changes occur in the following order: edema, ischemia, calcium overload, lipid peroxidation, microcirculation obstruction, and apoptosis. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Microcirculation | Mechanism |
| 19531626 | Changes of blood perfusion and microcirculation distribution in the stomach were investigated with laser Doppler blood perfusion imager (LDPI). | Evid Based Complement Alternat Med. 2011;2011:969231. doi: 10.1093/ecam/nep050. Epub 2010 Oct 20. | Microcirculation | Mechanism |
| 19531626 | It cannot only measure microcirculation of the skin but also measure general blood perfusion of the internal organs. | Evid Based Complement Alternat Med. 2011;2011:969231. doi: 10.1093/ecam/nep050. Epub 2010 Oct 20. | Microcirculation | Mechanism |
| 19531626 | In addition, the blood perfusion of microcirculation in other parts of the stomach increased in dissimilar degrees, it more obviously increased in the parts close to the moderate and small blood vessels. | Evid Based Complement Alternat Med. 2011;2011:969231. doi: 10.1093/ecam/nep050. Epub 2010 Oct 20. | Microcirculation | Mechanism |
| 19531626 | After acupuncture or EA, obviously a potent vasodilator reaction of gastric vessels was induced, with blood perfusion in the moderate and small vessels and microcirculation increased in dissimilar degrees, and this increase is the result offsetting the natural decrease of blood flow, so the action of acupuncture and EA increasing blood flow is obvious. | Evid Based Complement Alternat Med. 2011;2011:969231. doi: 10.1093/ecam/nep050. Epub 2010 Oct 20. | Microcirculation Blood Flow | Mechanism |
| 19531626 | After EA, the light green and yellow-red regions increased gradually, indicating that blood perfusion of the small vessels and microcirculation increased in dissimilar degrees. | Evid Based Complement Alternat Med. 2011;2011:969231. doi: 10.1093/ecam/nep050. Epub 2010 Oct 20. | Microcirculation | Mechanism |
| 26064171 | They have also pointed out a proven association between the primary mechanisms of the stimulatory effects of light and the secondary mechanisms defining the sanitation effects (bactericidal effect, cellular proliferation, and regulation of microcirculation). | Evid Based Complement Alternat Med. 2015;2015:687196. doi: 10.1155/2015/687196. Epub 2015 May 3. | Microcirculation | Mechanism |
| 26339273 | In the presence of IL-6 and TNF-α causes microvascular dysfunction in the intestinal mucosa, damaging its barrier function. | Evid Based Complement Alternat Med. 2015;2015:949065. doi: 10.1155/2015/949065. Epub 2015 Aug 3. | Microcirculation | Mechanism |
| 30127121 | Activating the Shh pathway can attenuate motor and sensory deficits after stroke by increasing microvascular density and neuronal survival (Chen et al., 2017) and inhibiting neuronal apoptosis (Meng et al., 2016). | Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. | Microcirculation | Mechanism |
| 35722406 | This causes progressive hypoxic-ischemic injury to the neurons and microcirculation in brain regions sensitive to injury (e.g., cerebral cortex, hippocampus), thereby simulating the pathological environment of VaD. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Microcirculation | Mechanism |
| 31485183 | 1-c), a low level of capillary hyperplasia was observed on the vertebral arterial surface, suggesting improved microcirculation, increased blood flow volume and a reduction in the symptoms of CSA. | Saudi J Biol Sci. 2019 Feb;26(2):390-394. doi: 10.1016/j.sjbs.2018.11.011. Epub 2018 Nov 20. | Microcirculation Blood Flow | Mechanism |
| 31312613 | Importantly, it has been reported that acupuncture intervention could significantly increase perfusion in local microcirculation, and affect the distribution of chemotherapeutic drugs in mice. | Front Oncol. 2019 Jul 2;9:576. doi: 10.3389/fonc.2019.00576. eCollection 2019. | Microcirculation | Mechanism |
| 31312613 | This result was in consistent with the above mentioned high level of COL IV and α-SMA in EAPTG group, because the integrity of microvascular basement membrane reduces the risk of metastasis. | Front Oncol. 2019 Jul 2;9:576. doi: 10.3389/fonc.2019.00576. eCollection 2019. | Microcirculation | Mechanism |
| 32967614 | Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication of diabetes. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Microcirculation | Mechanism |
| 32967614 | DPN is a recognized microvascular complication of diabetes, and its main etiology is loss of nourishment in tendons, vessels, and skin caused by blood stasis. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Microcirculation | Mechanism |
| 30899176 | 1-c), a low level of capillary hyperplasia was observed on the vertebral artery surface, which improved microcirculation, increased blood flow volume and alleviated CSA symptoms. | Saudi J Biol Sci. 2019 Mar;26(3):589-594. doi: 10.1016/j.sjbs.2018.12.007. Epub 2018 Dec 6. | Microcirculation Blood Flow | Mechanism |
| 30899176 | (1) To promote the division and proliferation of vascular endothelial cells, thereby generating new blood vessels; (2) To increase microvascular permeability as a vascular permeability factor. | Saudi J Biol Sci. 2019 Mar;26(3):589-594. doi: 10.1016/j.sjbs.2018.12.007. Epub 2018 Dec 6. | Microcirculation | Mechanism |
| 21799673 | Acute inflammation involves microvascular changes with increased vascular permeability, flow of exudation, including plasmatic protein, cell migration (primarily neutrophils) and amplification of endogenous chemical mediators into the site of injury. | Evid Based Complement Alternat Med. 2011;2011:217946. doi: 10.1093/ecam/neq036. Epub 2011 Jun 5. | Microcirculation | Mechanism |
| 34108361 | Recently, emerging evidence suggested that Klf4 was involved in the protective effect of microvascular endothelial cells from ischemic stroke injury by inhibiting apoptosis and inflammation. | Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. | Microcirculation | Mechanism |
| 35478723 | This suggests that the treatment improves microcirculation and blood flow and alleviates CSA symptoms. | Front Surg. 2022 Apr 11;9:778608. doi: 10.3389/fsurg.2022.778608. eCollection 2022. | Microcirculation Blood Flow | Mechanism |
| 28386185 | Cerebral ischemia and reperfusion appears microcirculation, inadequate supply of oxygen and glucose, ATP was rapidly depleted, mitochondrial ATP synthase failure, resulting in ATP dependent enzymes (including Ca2-ATP enzyme and Na+-K+-ATPase enzyme activity decreased, resulting in a massive outflow of intracellular K+, Na+, Clâ and Ca2+ large inflows of cells, resulting in cell, ion imbalance. | Saudi J Biol Sci. 2017 Mar;24(3):595-602. doi: 10.1016/j.sjbs.2017.01.031. Epub 2017 Jan 23. | Microcirculation | Mechanism |
| 30028333 | The pathophysiology of SCI involves the primary injury and the subsequent secondary injury, which results from a progressive local cascade of tissue destruction, including the change in the microenvironment of the injured spinal cord (ischemia of the microcirculation, edema, inflammation, glutamatergic excitotoxicity) and apoptosis. | Neural Regen Res. 2018 Jul;13(7):1241-1246. doi: 10.4103/1673-5374.235062. | Microcirculation Toxic Side Effects | Mechanism |
| 30028333 | The disturbance of the microcirculation after SCI is an important link between neurological injury, cardiovascular complications, and the change in hemodynamics after SCI (Sezer et al., 2015), which are consistent with stasis of the Governor Vessels in traditional Chinese medicine. | Neural Regen Res. 2018 Jul;13(7):1241-1246. doi: 10.4103/1673-5374.235062. | Microcirculation Cardiovascular Hemodynamics | Mechanism |
| 30028333 | Once SCI occurs, the platelet-activating factor content will rise rapidly in the SCI tissue, and prompt microvascular thrombosis, vascular endothelial cell damage, increased permeability of blood vessel walls, and blood-spinal cord barrier disruption, thereby altering the microenvironment of the injured spinal cord (Lindsberg et al., 1990; Faden et al., 1992; Xiao et al., 1996). | Neural Regen Res. 2018 Jul;13(7):1241-1246. doi: 10.4103/1673-5374.235062. | Microcirculation | Mechanism |
| 25120577 | As evidences given by recently extensive reports, the beneficial effects of acupuncture on brain ischemic damage in vivo or in vitro mainly focus on microcirculation, anti-apoptotic, anti-inflammation, neuron protection, brain metabolism. | Evid Based Complement Alternat Med. 2014;2014:962343. doi: 10.1155/2014/962343. Epub 2014 Jul 10. | Brain Protection Neuroprotection Microcirculation | Mechanism |