- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Emotion Regulation
- Depression
- Acupuncture anesthesia is beneficial for patients with depression undergoing surgery, as it can help stabilize mood and reduce the emotional impact of surgery.
- Anxiety
- Acupuncture anesthesia has anxiolytic effects, calming preoperative anxiety, and promoting a more relaxed state for patients before surgery.
- Sedation
- Acupuncture anesthesia provides sedation, allowing patients to undergo surgery in a tranquil and comfortable state without the need for excessive sedative drugs.
- Mood
- By regulating the body's natural balance, acupuncture anesthesia can positively influence mood, contributing to a more positive surgical experience.
Acupuncture anesthesia for Emotion Regulation-Mood
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 16414335 | Overall, controlled studies of acupuncture did not reliably improve hot flashes, sleep disturbances, or mood when compared with nonspecific acupuncture, estrogen therapy, or superficial needling. | Am J Med. 2005 Dec 19;118 Suppl 12B:109-17. doi: 10.1016/j.amjmed.2005.09.058. | Insomnia Mood | Review |
| 17264835 | Role of C tactile fibres in touch and emotion--clinical and research relevance to acupuncture. | Acupunct Med. 2006 Dec;24(4):169-71. doi: 10.1136/aim.24.4.169. | Mood | Review |
| 20204371 | Furthermore, greatly enhanced life quality of RA patients was obtained using acupuncture and massage to relieve pain, expand joint motion and modulate emotion which mainly correlated with the possible modulation of immune system, nerve system, endocrine system, etc. | Rheumatol Int. 2010 Apr;30(6):713-8. doi: 10.1007/s00296-010-1370-0. Epub 2010 Mar 5. | Immunity Endocrinology Mood | Review |
| 20451467 | Western descriptions of the clinical efficacy of acupuncture on pain, inflammation, motor dysfunction, mood disorders, and seizures are based on the stimulation of several classes of sensory afferent fibers and the consequent activation of physiological processes similar to those resulting from physical exercise or deep massage. | Auton Neurosci. 2010 Oct 28;157(1-2):9-17. doi: 10.1016/j.autneu.2010.03.020. Epub 2010 May 7. | Mood Motor Function | Review |
| 21563159 | OBJECTIVES: To determine the efficacy and safety of acupuncture in the acute management or rehabilitation (or both) of patients with a TBI, including cognitive, neurological, motor, communication, emotional, or behavioral complications, or a combination of such complications. | Cochrane Database Syst Rev. 2011 May 11;(5):CD007700. doi: 10.1002/14651858.CD007700.pub2. | Mood | Review |
| 21701996 | Western descriptions of the clinical efficacy of acupuncture on pain, inflammation, motor dysfunction, mood disorders, and seizures are based on the stimulation of several classes of sensory afferent fibers and the consequent activation of physiological processes similar to those resulting from physical exercise or deep massage. | Arch Ital Biol. 2011 Jun;149(2):247-55. doi: 10.4449/aib.v149i2.1365. | Mood Motor Function | Review |
| 23418645 | OBJECTIVES: To determine the efficacy and safety of acupuncture in the acute management or rehabilitation (or both) of patients with a TBI, including cognitive, neurological, motor, communication, emotional, or behavioral complications, or a combination of such complications. | Cochrane Database Syst Rev. 2012;12:CD007700. doi: 10.1002/14651858.CD007700.pub2. | Mood | Review |
| 23543554 | OBJECTIVES: To determine the efficacy and safety of acupuncture in the acute management or rehabilitation (or both) of patients with a TBI, including cognitive, neurological, motor, communication, emotional, or behavioral complications, or a combination of such complications. | Cochrane Database Syst Rev. 2013 Mar 28;(3):CD007700. doi: 10.1002/14651858.CD007700.pub3. | Mood | Review |
| 23882937 | The most common are: balneotherapy, exercise, cryotherapy, cognitive-behavioral psychotherapy and other forms of psychotherapy--in order to develop methods to combat stress and depressed mood, relaxation techniques, acupuncture, massage. | Pol Merkur Lekarski. 2013 Jun;34(204):360-2. | Mood | Review |
| 23904227 | Acupuncture was more effective than physiotherapy at relieving evening lumbo-pelvic pain and disability and improving pain and function when it was started at 26- rather than 20-weeks' gestation, although the effects were small.There was no significant difference in LBP and function for different support belts, exercise, neuro emotional technique or spinal manipulation (SMT), or in evening pelvic pain between deep and superficial acupuncture.Very low-quality evidence suggested a specially-designed pillow may reduce night-time LBP.Further research is very likely to have an important impact on our confidence in the estimates of effect and is likely to change the estimates. | Cochrane Database Syst Rev. 2013 Aug 1;(8):CD001139. doi: 10.1002/14651858.CD001139.pub3. | Mood | Review |
| 24744443 | Finally, we provide a brief overview of treatment options and discuss the efficacy of various medications, including benzodiazepines, antidepressants, antipsychotics and mood-stabilising agents, and various non-pharmacological treatment options, such as cognitive behavioural therapy, habituation therapy and acupuncture. | J Neurol Neurosurg Psychiatry. 2014 Oct;85(10):1138-44. doi: 10.1136/jnnp-2013-307339. Epub 2014 Apr 17. | Mood | Review |
| 24929454 | Acupuncture may also change the levels of neurotransmitters such as serotonin and dopamine, thereby affecting the emotional state and craving. | J Acupunct Meridian Stud. 2014 Jun;7(3):105-14. doi: 10.1016/j.jams.2013.07.008. Epub 2013 Aug 17. | Mood | Review |
| 26007331 | Because the LPNN is related to sleep and emotions, this might explain the improved qualities of life and sleep after acupuncture. | Explore (NY). 2015 Jul-Aug;11(4):281-91. doi: 10.1016/j.explore.2015.04.004. Epub 2015 Apr 28. | Mood | Review |
| 26880252 | The meta-analysis also demonstrated that acupuncture produced small-to-large effects on adverse symptoms including pain, fatigue, sleep disturbance, and some gastrointestinal discomfort; however, no significant effect was found on the frequency of hot flashes (Cohen's d = -0.02; 95% CI = -1.49 to 1.45; P = 0.97; I(2) = 36%) and mood distress (P > 0.05). | J Pain Symptom Manage. 2016 Apr;51(4):728-747. doi: 10.1016/j.jpainsymman.2015.11.027. Epub 2016 Feb 12. | Adverse Reactions Insomnia Mood | Review |
| 26896946 | This lesson outlines a brief history of acupuncture and how it may be used to treat various types of physical and emotional pain and specific conditions, including overactive bladder and psoriasis. | Curr Pain Headache Rep. 2016 Apr;20(4):22. doi: 10.1007/s11916-016-0552-1. | Mood | Review |
| 29180347 | Accordingly, acupuncture combined with Madopar appeared to have a positive effect on activities of daily life and the general condition of patients with PD, but was not better than Madopar alone for the treatment of mental activity, behaviour, mood and motor disability. | Acupunct Med. 2017 Dec;35(6):404-412. doi: 10.1136/acupmed-2016-011342. Epub 2017 Nov 27. | Mood Motor Function | Review |
| 30273275 | Is Tapping on Acupuncture Points an Active Ingredient in Emotional Freedom Techniques? A Systematic Review and Meta-analysis of Comparative Studies. | J Nerv Ment Dis. 2018 Oct;206(10):783-793. doi: 10.1097/NMD.0000000000000878. | Mood | Review |
| 31076901 | Due to the multimorphism of cancer pain, certain mind-body therapies acting on anxiety, stress, depression, or mood disturbances (such as massage, acupuncture, healing touch, hypnosis, and music therapy) are efficient on cancer pain. | Support Care Cancer. 2019 Aug;27(8):3119-3132. doi: 10.1007/s00520-019-04829-7. Epub 2019 May 11. | Cancer Pain Anxiety Depression Mood | Review |
| 31259837 | To date, the role of traditional Chinese acupuncture in mood disorders in the postpartum period is unclear. | J Chin Med Assoc. 2019 Sep;82(9):719-726. doi: 10.1097/JCMA.0000000000000140. | Mood | Review |
| 31989720 | Interventions explored were hypnosis, simple massage, distraction, relaxation, spiritual care, harp music, music therapy, listening to natural sounds, passive exercise, acupuncture, ice packs and emotional support. | J Clin Nurs. 2020 May;29(9-10):1488-1498. doi: 10.1111/jocn.15194. Epub 2020 Feb 7. | Mood | Review |
| 32538020 | Effect of acupuncture on emotional disorder in patients with chronic pain: a Meta-analysis. | Zhongguo Zhen Jiu. 2020 Jun 12;40(6):657-63. doi: 10.13703/j.0255-2930.20190528-k0006. | Mood | Review |
| 32538020 | OBJECTIVE: To systematically review the effect of acupuncture on emotional disorder in the patients with migraine and knee osteoarthritis and its effect time limit. | Zhongguo Zhen Jiu. 2020 Jun 12;40(6):657-63. doi: 10.13703/j.0255-2930.20190528-k0006. | Mood | Review |
| 32538020 | Regarding the immediate effect, the score of the emotional function subscale of migraine-specific quality-of-life questionnaire (MSQ) in the acupuncture group was higher than the control group (6.38[2.78,9.98], I (2)=25%). | Zhongguo Zhen Jiu. 2020 Jun 12;40(6):657-63. doi: 10.13703/j.0255-2930.20190528-k0006. | Mood | Review |
| 32538020 | In view of the emotional function subscale of the short-form of health survey (SF-36/SF-12), and the scores of the mental function and negative mode scale in Spain's index of quality of life (PQLC), there were no significant differences in the scores between the acupuncture group and the control group. | Zhongguo Zhen Jiu. 2020 Jun 12;40(6):657-63. doi: 10.13703/j.0255-2930.20190528-k0006. | Mood | Review |
| 32538020 | In 3 months of treatment, the score of the emotional function subscale of MSQ in the acupuncture group was higher than the control group (9.66 [3.06,16.25], I (2)=44%). | Zhongguo Zhen Jiu. 2020 Jun 12;40(6):657-63. doi: 10.13703/j.0255-2930.20190528-k0006. | Mood | Review |
| 32538020 | CONCLUSION: Acupuncture effectively maintains the healthy emotion in the patients with migraine and the effect is sustainable for 3 months after treatment. | Zhongguo Zhen Jiu. 2020 Jun 12;40(6):657-63. doi: 10.13703/j.0255-2930.20190528-k0006. | Mood | Review |
| 32538020 | But the improvement of acupuncture is not remarkable in emotional disorder induced by knee osteoarthritis. | Zhongguo Zhen Jiu. 2020 Jun 12;40(6):657-63. doi: 10.13703/j.0255-2930.20190528-k0006. | Mood | Review |
| 33838089 | The results showed that different CAM interventions (acupuncture, Traditional Chinese medicine [TCM], relaxation, Qigong) significantly improved various psychological symptoms (depression, anxiety, stress, sleep quality, negative emotions, quality of life) and physical symptoms (inflammatory factors, physical activity, chest pain, and respiratory function) in COVID-19 patients. | Rev Environ Health. 2021 Apr 12;36(3):443-450. doi: 10.1515/reveh-2021-0012. Print 2021 Sep 27. | Anxiety Depression Mood Sleep Quality | Review |
| 37356604 | Area of secondary hypersensitivity was decreased by anodal transcranial direct current stimulation, emotional disclosure, cognitive behavioral therapy, hyperbaric oxygen therapy, placebo analgesia, or spinal manipulation; increased by directing attention to the induction site, nicotine deprivation, or sleep disruption (in males only); and unaffected by cathodal transcranial direct current stimulation, thermal change, acupuncture, or electroacupuncture. | J Pain. 2023 Oct;24(10):1759-1797. doi: 10.1016/j.jpain.2023.06.013. Epub 2023 Jun 24. | Mood | Review |
| 37647670 | In TCM, there is a history of long-term medication for epilepsy, the main treatment for epilepsy is TCM drugs and its prescription, supplemented by TCM modalities such as acupuncture therapy, moxibustion therapy, tuina, emotion adjustment therapy, etc. | Phytomedicine. 2023 Nov;120:155022. doi: 10.1016/j.phymed.2023.155022. Epub 2023 Aug 14. | Mood | Review |
| 37921943 | Ayurvedic and traditional Chinese medicine practices including yoga, meditation, tai chi, and acupuncture may help improve mobility, mood, sleep, and quality of life. | Curr Neurol Neurosci Rep. 2023 Nov;23(11):717-726. doi: 10.1007/s11910-023-01312-z. Epub 2023 Nov 3. | Mood | Review |
| 20824863 | These include herbal remedies (ginger, chamomile, peppermint, raspberry leaf), acupressure, acustimulation bands and acupuncture, relaxation, autogenic feedback training, homeopathic remedies (nux vomica, pulsatilla), massage, hypnotherapy, dietary interventions, activity interventions, emotional support, psychological interventions and behavioural interventions/modifications. | Cochrane Database Syst Rev. 2010 Sep 8;(9):CD007575. doi: 10.1002/14651858.CD007575.pub2. | Mood | Review |
| 23338773 | Meanwhile, the intervention group also showed a decrease in depressive mood as compared to the control group (P = 0.003), suggesting that acupuncture plus massage in addition to usual care reduce pain and depressive mood among postoperative cancer patients when compared with usual care alone. | Curr Pain Headache Rep. 2013 Mar;17(3):321. doi: 10.1007/s11916-013-0321-3. | Mood | Review |
| 27417472 | Acupuncture for Delirium, Agitation, Withdrawal and Emotional Conditions | Children (Basel). 2014 Aug 21;1(2):134-48. doi: 10.3390/children1020134. | Mood | Review |
| 28436999 | As trials have been conducted on the effects of acupuncture, healing touch, and stress management on depression and improvement in mood, these therapies can be considered (Grades C). | CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. | Depression Mood | Review |
| 28436999 | Five trials assessed acupuncture as a treatment for depression/mood (but as a secondary outcome) and only one trial was large, with mixed findings in terms of effect. | CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. | Depression Mood | Review |
| 28436999 | Massage has been shown to improve mood and acupressure and electroacupuncture decrease CINV. | CA Cancer J Clin. 2017 May 6;67(3):194-232. doi: 10.3322/caac.21397. Epub 2017 Apr 24. | Mood | Review |
| 28459738 | Integrative medicine promotes the physical, emotional, and spiritual health of a person by incorporating complementary therapies (physical activity, diet, dietary supplements, mind-body modalities, acupuncture, and massage therapy) with conventional therapy. | Curr Opin Oncol. 2017 Jul;29(4):235-242. doi: 10.1097/CCO.0000000000000376. | Mood | Review |
| 28664077 | Chae et al reported that increases in the corticotrophin-releasing factor may be involved in the negative emotional state associated with nicotine withdrawal, and acupuncture at HT7 may attenuate anxiety-like behavior following nicotine withdrawal by modulating corticotrophin-releasing factor in the amygdala. | Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. | Anxiety Mood | Review |
| 30117343 | Acupuncture prescriptions varied in needling protocol, points, and meridian systems; indications for acupuncture mainly focused on hot flashes, fatigue, pain, joint stiffness, mood regulation, and quality of life (Tables 1 and 2). | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Mood | Review |
| 30416533 | Previous studies have shown that acupuncture plays an important role in correcting dysregulation of stress-related brain emotional systems and improves the efficiency of homeostatic mechanisms of emotion. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Mood | Review |
| 30416533 | Thus, it is not unexpected that acupuncture ameliorates negative emotional states of the addiction cycle by regulating neurotransmitters in the brain that have long been associated with addictive behaviors. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Mood | Review |
| 30416533 | Thus, it can be expected that acupuncture can reduce drug relapse by improving negative emotional state in drug dependence through modulation of the BDNF-mediated mesolimbic dopamine pathway. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Mood | Review |
| 30416533 | In conclusion, studies provide strong evidences that acupuncture reduces stress-induced negative emotional state and relapse to drug-seeking behavior by modulating the mesolimbic dopamine system and CRF stress system. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Mood | Review |
| 30809158 | Evidence shows that acupuncture can increase a patient's verbal and motor skills and improve mood and cognitive function. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Cognitive Function Mood | Review |
| 30854010 | Eight acupuncture points on the abdomen, including Tianshu (ST-25) bilateral, Weidao (GB-28) bilateral, Zhongwan (REN-12), Shuifen (REN-9), Guanyuan (REN-4), Sanyinjiao (SP-6), and additional points including Quchi (LI-11) and Fenlong (ST-40) for excess mood (patients with higher energy) and Qihai (REN-6) and Yinlingqau (SP-9) for deficiency mood (patients with lower energy) on both lower legs, were selected. | Evid Based Complement Alternat Med. 2019 Feb 3;2019:5796381. doi: 10.1155/2019/5796381. eCollection 2019. | Mood | Review |
| 31370200 | People who favour alternative treatments may elect to have acupuncture rather than other adjunctive approaches, such as a mood stabilizing agent like lithium. | J Clin Med. 2019 Jul 31;8(8):1140. doi: 10.3390/jcm8081140. | Mood | Review |
| 31467579 | have shown that amelioration of pain by electric acupuncture is associated with improved anxiety and mood disorders simultaneously, thereby promoting recovery. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Anxiety Mood | Review |
| 31680841 | Assuming that acupuncture is a pain stimulus that travels bottom-up and activates the pain networks, it must also be assumed that expectations, instructions, emotions, and other context factors modulate acupuncture effects. | Front Neurosci. 2019 Oct 17;13:1110. doi: 10.3389/fnins.2019.01110. eCollection 2019. | Mood | Review |
| 31802723 | Fifteen studies were included in the final review and findings tended to be in support of acupuncture and acupressure for symptoms such as agitation, anxiety, ADL function, sleep, mood, depression, and neuropsychological disturbances. | West J Nurs Res. 2020 Oct;42(10):867-880. doi: 10.1177/0193945919890552. Epub 2019 Dec 5. | Anxiety Depression Mood | Review |
| 32038351 | The research reviewed includes studies that investigate effects of massage therapy, reflexology, acupuncture, functional relaxation, emotional freedom technique, Rolfing, yoga, tai-chi, and dance/movement therapy on psychological conditions across the lifespan. | Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. | Mood | Review |
| 32038351 | Results demonstrated that overall, massage therapy, tai-chi, dance/movement therapy, functional relaxation, reflexology, acupuncture and emotional freedom technique seem to alleviate stress, depression, anxiety, bipolar disorder and facilitate pain reduction. | Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. | Anxiety Depression Mood | Review |
| 32038351 | Regarding psychopathology, acupuncture has demonstrated promising results for alleviating depression, bipolar disorder and mood associated with premenstrual disorder. | Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. | Depression Mood | Review |
| 32038351 | originally developed a technique for self-tapping on acupuncture points as a means to decrease unwanted emotions or stress and later simplified this method calling it the Emotional Freedom Technique (EFT). | Front Psychol. 2020 Jan 24;10:2907. doi: 10.3389/fpsyg.2019.02907. eCollection 2019. | Mood | Review |
| 32195928 | Study has found that acupuncture can mediate depressive emotion by regulating the deoxyribonucleic acid (DNA) methylation and histone modifications of brain-derived neurotrophic factor (BDNF). | Medicine (Baltimore). 2020 Mar;99(12):e18969. doi: 10.1097/MD.0000000000018969. | Mood | Review |
| 32718258 | Acupuncture needling protocols, points, and meridian systems varied, with outcomes including pain-related functional interference, fatigue, gastrointestinal symptoms, postoperative upper limb stiffness, hot flashes, and sleep and mood disorder symptoms (Table 1). | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Mood | Review |
| 32718258 | This systematic review has presented an updated view on the clinical applicability of acupuncture, and related therapies for symptom management, the small sample size effect of partial outcome (gastrointestinal symptoms, Kupperman index, physical well-being, social well-being, emotional well-being, TNF, and IL) exists due to the influence of the small sample size. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Mood | Review |
| 32718258 | Despite our inclusion of many RCTs, a limited number of studies reported particular indications of acupuncture, and many analyses also had only 2 outcomes available for inclusion: social well-being, emotional well-being, TNF, and IL (2 RCTs). | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Mood | Review |
| 33014115 | We extracted the data including the year of publication, nationality of the author, characteristics of the participant (patients or the health, gender, handedness, diseases, emotional state, and acupuncture experience), sample size, acupuncture intervention (method of intervention, acupoint selection, manipulation procedure, Deqi/needle sensation, and acupuncturist), outcome assessment, neuroimaging technology, and ethical review. | Evid Based Complement Alternat Med. 2020 Sep 21;2020:8502530. doi: 10.1155/2020/8502530. eCollection 2020. | Mood | Review |
| 33584181 | We used the search string [pain(MeSH)] OR [headache(MeSH)] OR [osteoarthritis(MeSH)] OR [fibromyalgia(MeSH)] OR [cancer (MeSH)], AND [acupuncture(MeSH)], AND [psychological disorder(MeSH)], OR [mental disorder(MeSH)] OR [emotional (MeSH)], OR [anxiety(MeSH)], OR [depression(MeSH)] for PubMed and adapted it for Web of Science and Embase. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Anxiety Depression Mood | Review |
| 33584181 | The majority of the studies suggest that acupuncture can significantly improve the emotional symptoms (such as anxiety and depression) in patients with chronic pain compared with both usual care and waiting list. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Anxiety Depression Mood | Review |
| 33584181 | The prevalence of use of acupuncture and other complementary and alternative medicine approaches in chronic headaches was 62%, and the results were promising, particularly in patients with mood or anxiety disorders caused by headache. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Anxiety Mood | Review |
| 33584181 | Clinical evidences showed that acupuncture could improve chronic headaches related symptoms, which led to improvements in emotional well-being of patients. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | A randomized clinical trial (RCT) of 249 participants with migraine compared electroacupuncture (five sessions per week for 4 weeks, each session lasted 30 min) with sham acupuncture (insertion of sterile disposable needles at non-acupuncture points) or waiting-list treatment and found that electroacupuncture produced a greater reduction in the frequency of migraine and a better therapeutic effect on emotional functional subscale of Migraine-Specific Quality of Life Questionnaire than sham acupuncture or waiting-list treatment (acupuncture vs. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | An intervention study of 72 patients with chronic low back pain found that after 8 weeks of acupuncture treatment (once a week, each treatment lasted 15 min), patients reported a significant decrease in the pain (measured with Numerical Rating Scale) and in the total mood disturbance score, as measured by the Profile of Mood States (P < 0.05). | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | Moreover, in a study of the mechanism of acupuncture in fibromyalgia patients, the authors found that after acupuncture, a complex interaction might occur between the insula cortex and the anterior cingulate, which induced a relief of pain and improvement of emotional experience. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Pain Relief Mood | Review |
| 33584181 | In addition, the serotonergic system in the dorsal raphe nucleus has been proved to participate in the descending modulation of pain and has a role in the effects of acupuncture on emotional disorders caused by pain. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | Acupuncture can improve the emotion of pain by modulating the opioid receptors in the cingulate cortex. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | Intra-rostral anterior cingulate cortex administration of antagonists against opioid receptor antagonist blocked electroacupuncture action, which demonstrated that electroacupuncture activated opioid receptors in the rostral anterior cingulate cortex to inhibit the emotion of pain. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | It should be noted that acupuncture cannot improve emotional symptoms caused by chronic pain in some cases. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | Another study assessed the effects of acupuncture on mood expressions in patients with chronic pain. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | It showed that for women, positive mood scales highly significantly increased and negative mood scales decreased after acupuncture treatment in their intensity highly. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | However, there was no significant influence of acupuncture on positive or negative mood scales of the male patients. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33584181 | Finally, how the emotion/pain-related brain nuclei work together and the peripheral mechanism of acupuncture on chronic pain-related psychological states should be further studied. | Front Neurosci. 2021 Jan 27;14:626497. doi: 10.3389/fnins.2020.626497. eCollection 2020. | Mood | Review |
| 33586504 | Given that this meta-analysis has shown that acupuncture is effective, perhaps in the future, all clinical and methodological experts should focus on finding a proper sham-acupuncture intervention to be used in acupuncture trials to concretely and scientifically show the effects of acupuncture; then, the medical community would have evidence that acupuncture is an acceptable and effective treatment for some symptoms such as pain and disorders such as insomnia and mood disorders. | Integr Cancer Ther. 2021 Jan-Dec;20:1534735420980811. doi: 10.1177/1534735420980811. | Insomnia Mood | Review |
| 33633868 | Several lines of evidence indicate that acupuncture treatment can improve the social and emotional responses of autistic patients characterized by impaired social behavior. | Transl Neurosci. 2021 Feb 16;12(1):96-102. doi: 10.1515/tnsci-2021-0011. eCollection 2021 Jan 1. | Mood | Review |
| 33680223 | The keywords used for the search consist of three parts: chronic pain (e.g., musculoskeletal pain, back pain), depression (e.g., depression, affective disorder, affective symptoms, mood), and acupuncture (e.g., acupuncture, electroacupuncture needling, acupoint). | Pain Res Manag. 2021 Feb 22;2021:6617075. doi: 10.1155/2021/6617075. eCollection 2021. | Depression Mood | Review |
| 33762855 | Five major search engines, namely MEDLINE, PubMed, EMBASE, and Cochrane Library, were searched for articles published prior to October 2020 that matched any combination of the following key words: [primary dysmenorrhea] OR [dysmenorrhea] OR [menstrual pain] AND [life-style] OR [alternative medicine] OR [complementary medicine] OR [diet] OR [physical activity] OR [herbs] OR [acupressure] OR [acupuncture] OR [aromatherapy] OR [heat therapy] AND [emotional support] AND [psychological support] AND [psychotherapy. | Int J Womens Health. 2021 Mar 17;13:327-336. doi: 10.2147/IJWH.S264023. eCollection 2021. | Mood | Review |
| 33762855 | In terms of QoL in women with PD that receive acupuncture alternative therapy, the evidence shows improved physical function, mental health, bodily pain, vitality, social function, and emotional role, while no adverse outcomes by this intervention were reported. | Int J Womens Health. 2021 Mar 17;13:327-336. doi: 10.2147/IJWH.S264023. eCollection 2021. | Mood | Review |
| 33883931 | Acupuncture is widely considered to be a potential effective therapy in treatment of depression and anxiety but has been involved in very limited studies concerning emotional disorders during PIPN, so further exploration is called for. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Anxiety Depression Mood | Review |
| 34093111 | It reflected the participation of the sensory and emotional parts of the pain processed the acupuncture analgesia. | Front Neurosci. 2021 May 20;15:648305. doi: 10.3389/fnins.2021.648305. eCollection 2021. | Mood | Review |
| 34093119 | After 30 min of acupuncture treatment, patients with MWoA showed increased metabolism in brain regions involved in the processing of pain including cognitive processing of pain [e.g., orbitofrontal cortex (Yang et al.,), the parahippocampal gyrus (Yang et al.,)] and affective-emotional processing of pain [e.g., the insula (Liu et al.,). | Front Neurosci. 2021 May 20;15:674852. doi: 10.3389/fnins.2021.674852. eCollection 2021. | Mood | Review |
| 34093119 | As shown in Supplementary Table 3 and Figure 4, Researchers have observed increased ReHo/ALFF/brain metabolites after acupuncture treatment in brain regions involved in the processing of pain including the affective-emotional processing of pain [e.g., the insula (Zhao et al.,; Qin et al.,), cerebellum (Zhao et al.,), and brainstem (Zhao et al.,)], the cognitive processing of pain [e.g., the orbitofrontal cortex (Li et al.,; Gu et al.,; Qin et al.,)] and the DPMS [e.g., the rostral ventromedial medulla/trigeminocervical complex (Li et al.,). | Front Neurosci. 2021 May 20;15:674852. doi: 10.3389/fnins.2021.674852. eCollection 2021. | Mood | Review |
| 34122180 | These findings suggest that acupuncture can improve both the depressed mood and quality of life in women with PMD. | Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. | Mood | Review |
| 34122180 | Acupuncture alone or combined with standard care (antidepressant/antidepressant + HRT) is superior to standard care alone in improving depressed mood in perimenopausal women. | Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. | Mood | Review |
| 34122180 | This review has provided a low-to-moderate level of evidence supporting acupuncture as a safe and effective alternative to or adjuvant to standard care (antidepressant/antidepressant + HRT) in improving depressed mood as well as other menopause-related symptoms among women with PMD. | Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. | Mood | Review |
| 34221081 | To explore constitutional differences, the studies measured HRV at resting level with paced breathing, after acupuncture stimulation, or other interventions such as meditation, forest healing program, autogenic training, emotional stimulus, and constitutional herbal formula. | Evid Based Complement Alternat Med. 2021 Jun 15;2021:6613798. doi: 10.1155/2021/6613798. eCollection 2021. | Mood | Review |
| 34408622 | Regulation of Emotions and Cognition Associated With Pain by Acupuncture | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Mood | Review |
| 34408622 | Acupuncture can not only reduce pain sensation, but can also help manage pain-related emotion and cognition by regulating neurotransmitters and neuroplasticity, thus alleviating pain and related factors in an all-round manner. | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Mood | Review |
| 34408622 | Acupuncture can also inhibit the release of central excitatory neurotransmitters and promote the release of inhibitory neurotransmitters, reduce the interaction between neurotransmitters, and relieve pain and pain-related emotions and cognition (Figure 4). | Front Neurosci. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670. eCollection 2021. | Mood | Review |
| 34489749 | Collectively, these findings may give us some clues whether the effects of acupuncture on emotion-related diseases are related to its effect on the ACC. | Front Psychiatry. 2021 Aug 20;12:670739. doi: 10.3389/fpsyt.2021.670739. eCollection 2021. | Mood | Review |
| 34526816 | For preoperative emotions, one study demonstrated women in the acupuncture group were more stressed (P<0.05), a different result was found in another two studies that there was no difference between their groups (P>0.05). | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Mood | Review |
| 34675729 | In the first category, six RCTs confirmed significant improvements acupuncture produced on sleep duration and quality as well as depressed mood, when compared with waitlist or placebo controls. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Mood | Review |
| 34675729 | It is hence reasonable to summarize that acupuncture can directly elevate serotonin levels, but also indirectly strengthen the benign regulation of serotonin in sleep and mood with this increased E2. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Mood | Review |
| 34675729 | Although there is no direct evidence investigating the effect of acupuncture on 8-OHdG in PMD populations, MA was found to improve cognitive function and mood in patients with vascular dementia, along with significant decline in urinary 8-OHdG. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Cognitive Function Mood | Review |
| 34675729 | Our review demonstrates that acupuncture has a positive and broad effect on PMI and PMD, being beneficial on mood, sleep, and vasomotor symptoms. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Mood | Review |
| 35085351 | Acupuncture for emotional symptoms in patients with functional gastrointestinal disorders: A systematic review and meta-analysis | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | To systematically evaluate the clinical efficacy and safety of acupuncture for emotional symptoms in patients with FGIDs. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | This meta-analysis found that acupuncture can alleviate emotional symptoms in FGID patients better than pharmacotherapy. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | Evidence has shown that acupuncture can relieve gastrointestinal symptoms of FGIDs and emotional symptoms such as depression and anxiety. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Anxiety Depression Mood | Review |
| 35085351 | Hence, in this study, we summarized evidence from randomized controlled trials (RCTs) and evaluated the effectiveness of acupuncture on relieving emotional symptoms in patients with FGIDs. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | In recent years, studies have found that acupuncture can be used to treat gastrointestinal diseases as well as emotional symptoms. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | The mechanism by which acupuncture regulates the brain-gut axis to treat emotional symptoms is a current research hotspot. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | In addition, this study found that the type of acupuncture was not related to the effect of acupuncture in the treatment of emotional symptoms in FDIG patients, and both manual acupuncture and electroacupuncture can reduce their psychological symptoms to a greater degree than conventional drugs. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | To the best of our knowledge, this is the first systematic review of acupuncture treatment for emotional symptoms in FGIDs patients. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35085351 | This meta-analysis found that acupuncture can alleviate emotional symptoms in FGID patients better than pharmacotherapy. | PLoS One. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166. eCollection 2022. | Mood | Review |
| 35145373 | In IBS rats, electroacupuncture relieved mood disorder and repaired the intestinal mucosal barrier by decreasing hypothalamic and gastrointestinal expression of CRF, indicating a potentially dual therapeutic role for acupuncture in regulating disorders of gut-brain interaction in the FGID model. | Front Neurosci. 2022 Jan 25;15:781215. doi: 10.3389/fnins.2021.781215. eCollection 2021. | Mood | Review |
| 35145373 | Additionally, female predominance, smoking, emotional disorder, atopic diseases, and autoimmune diseases were the risk factors of FD, however, the influences in acupuncture-treatment response by these factors still need to be identified. | Front Neurosci. 2022 Jan 25;15:781215. doi: 10.3389/fnins.2021.781215. eCollection 2021. | Mood | Review |
| 35233354 | Acupuncture can increase default mode network and sensorimotor network connectivity with brain areas controlling pain, emotion, and memory. | Tzu Chi Med J. 2021 Apr 19;34(1):35-43. doi: 10.4103/tcmj.tcmj_275_20. eCollection 2022 Jan-Mar. | Mood | Review |
| 35380733 | More specifically, the associated effects of acupuncture have been categorized as secondary benefits, such as feeling relaxed, elated, or tired or having improved mood and sleep. | Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. | Mood | Review |
| 35380733 | Central mechanisms of acupuncture include deactivation of the limbic system, which is important for emotion and internal homeostasis, which impact chronic pain. | Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. | Mood | Review |
| 35481320 | studied breast cancer patients undergoing reconstructive surgery who were evaluated post operatively using visual analog scores (VAS) to determine pain, mood, energy, relaxation, insomnia, stress, anxiety, alertness, fatigue, and tension after massage alone or with the addition of acupuncture. | Cureus. 2022 Mar 24;14(3):e23443. doi: 10.7759/cureus.23443. eCollection 2022 Mar. | Insomnia Anxiety Mood | Review |
| 35481320 | demonstrated that acupuncture in combination with massage resulted in decreased levels of anxiety, relaxation, nausea, fatigue, pain, and mood following breast reconstructive surgery compared to baseline. | Cureus. 2022 Mar 24;14(3):e23443. doi: 10.7759/cureus.23443. eCollection 2022 Mar. | Nausea and Vomiting Anxiety Mood | Review |
| 35481320 | Although the benefits of this intervention were similar to the benefits of massage-only intervention in regards to fatigue, anxiety, relaxation, nausea, pain, and mood scores, the massage plus acupuncture intervention increased stress levels compared to massage alone. | Cureus. 2022 Mar 24;14(3):e23443. doi: 10.7759/cureus.23443. eCollection 2022 Mar. | Nausea and Vomiting Anxiety Mood | Review |
| 35492706 | These three RCTs also adopted HAMD (17- or 24-item version) to explore the regulating effect of verum- or placebo-acupuncture on depressed mood. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Mood | Review |
| 35492706 | Similarly, acupuncture at HT7 was found to activate cerebral regions highly associated with cognition, sleep, and emotion. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Mood | Review |
| 35492706 | Existing hypotheses also include that acupuncture exerts a hypnotic effect through the modulation of regional brain activity and functional connectivity, particularly in emotion-related areas. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Mood | Review |
| 35492706 | This review has provided a low to moderate level of evidence supporting acupuncture as a safe and effective remedy alternative to or adjuvant to conventional pharmacotherapy (antidepressant and/or hypnotic) in improving insomnia as a major symptom among patients with active depression as well as their depressed mood. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Insomnia Depression Mood | Review |
| 35494482 | Currently, there are several assessment scales for acupuncture senses, such as Visual Analog Scales (VAS) that quantified the five acupuncture senses and the anxiety degree and the Massachusetts General Hospital Acupuncture Sensation Scale (MASS) that contains VAS and two subscales which are used to evaluate the acupuncture sensation spreading and patients' mood. | Neural Plast. 2022 Apr 21;2022:5635596. doi: 10.1155/2022/5635596. eCollection 2022. | Anxiety Mood | Review |
| 35548526 | Energy psychology is a novel treatment for emotional healing and psychological development that involves the somatic stimulation of acupuncture points (acupoints) by tapping on them with the fingertips. | Front Psychol. 2022 Apr 25;13:856209. doi: 10.3389/fpsyg.2022.856209. eCollection 2022. | Mood | Review |
| 35548526 | Tapping on specified acupuncture points whose stimulation has been shown to decrease activation signals in the amygdala, for instance, appears to rapidly decrease elevated emotional responses in stressful situations. | Front Psychol. 2022 Apr 25;13:856209. doi: 10.3389/fpsyg.2022.856209. eCollection 2022. | Mood | Review |
| 35755043 | Since originating in China, acupuncture has been practiced for thousands of years to treat numerous conditions including chronic pain and mood disorders. | Front Med (Lausanne). 2022 Jun 9;9:868079. doi: 10.3389/fmed.2022.868079. eCollection 2022. | Mood | Review |
| 35832139 | Anchored on the midnight-noon ebb-flow theory, the ziwuliuzhu technique in combination with an antidepressant was more effective at alleviating mood symptoms than acupuncture alone. | Psychol Res Behav Manag. 2022 Jul 7;15:1689-1706. doi: 10.2147/PRBM.S310207. eCollection 2022. | Mood | Review |
| 35884060 | More specific SCD-related limitations and disease process comorbidities may also pose inherent barriers to care, which include physical limitations from pain, feelings of fatigue, feelings of stigma, and emotional responses to health care visits for pain management, interpretation of acupuncture as an invaluable, and interpretation of acupuncture as an experimental treatment may provide additional barriers. | Children (Basel). 2022 Jul 19;9(7):1076. doi: 10.3390/children9071076. | Mood | Review |
| 35911986 | One study in this review showed decreased activation of PFC after EA treatment; another study formulated that acupuncture might exert potential influence on the modulation of 5-HT pathway in insula and mood via ascending pathway in the higher cortical center (pulvinar and medical nucleus of the thalamus) to process pain in IBS-D. | Front Neurosci. 2022 Jul 15;16:918701. doi: 10.3389/fnins.2022.918701. eCollection 2022. | Mood | Review |
| 35922617 | have shown that acupuncture may exert analgesic effects through the following three levels: (1) in the periphery, acupuncture stimulation promoted the release of endogenous opioids, and then inhibited the nociception of peripheral nerve endings; (2) at the spinal level, acupuncture blocked nociceptive transmission while increasing levels of opioids, norepinephrine, and 5-HT; (3) in the brain, acupuncture worked mainly by inhibiting the production of pain sensations and emotional components. | Pain Ther. 2022 Dec;11(4):1095-1112. doi: 10.1007/s40122-022-00415-8. Epub 2022 Aug 3. | Analgesic Effect Mood | Review |
| 35968313 | Further functional decoding analysis showed that acupuncture on ST36 was associated with pain, secondary somatosensory, sound and language processing, and mood regulation. | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Mood | Review |
| 35968313 | Our findings may have clinical implications for acupuncture in analgesia, language processing, and mood disorders. | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Mood | Review |
| 35968313 | As shown in Table 4, which depicts the functional profiles, acupuncture on ST36 was associated with SII stimulation, such as pain, touch, tactile, and electrical stimulation; sound and language processing, such as auditory sensory and speech; and mood regulation (Figure 4). | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Mood | Review |
| 35968313 | Further functional decoding implied that our findings may help to elucidate the neural targets of acupuncture at ST36 for pain, speech, and mood disorder management. | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Mood | Review |
| 35968313 | Our findings facilitate an understanding of the mechanisms of acupuncture treatment and provide neurological evidence for the clinical implications of acupuncture in analgesia, language processing, and mood disorders. | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Mood | Review |
| 35978992 | These meta-analyses show that acupuncture treatment effectively affects global health status, physical functioning, pain, emotional, insomnia, and social functioning. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Insomnia Mood | Review |
| 35978992 | The results showed that acupuncture could improve CIBP patients' global health status, physical functioning, pain, emotional, insomnia, social functioning, and KPS scores. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Insomnia Mood | Review |
| 36212046 | Functional characterization showed that these regions were mainly involved in cognitive, emotional, and decision-making regions, which may provide a possible central mechanism for acupuncture treatment of MCI from a neuroimaging perspective. | Front Aging Neurosci. 2022 Sep 23;14:914049. doi: 10.3389/fnagi.2022.914049. eCollection 2022. | Mood | Review |
| 36212046 | The above brain regions were mainly involved in cognitive, emotional, and decision-making regions, which confirmed to some extent the modulatory effect of acupuncture on brain regions in MCI. | Front Aging Neurosci. 2022 Sep 23;14:914049. doi: 10.3389/fnagi.2022.914049. eCollection 2022. | Mood | Review |
| 36212046 | Acupuncture of LR3 and K13 specifically regulates blood flow and activates brain regions associated with emotion, decision making, semantic processing, memory, attention, and sensation. | Front Aging Neurosci. 2022 Sep 23;14:914049. doi: 10.3389/fnagi.2022.914049. eCollection 2022. | Mood Blood Flow | Review |
| 36340786 | Clinical studies have demonstrated that acupuncture may be a beneficial migraine treatment, particularly in decreasing pain intensity, duration, emotional comorbidity, and days of acute medication intake. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Mood | Review |
| 36340786 | In light of their findings, the verum acupuncture group showed a significant decrease in migraine frequency, migraine days, and headache intensity compared to placebo acupuncture, as well as a long-term improvement in the emotional domains of quality of life. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Mood | Review |
| 36340786 | These correlations jointly indicate that acupuncture is implicated in the encoding of pain sensation and nociceptive emotions through the ACC. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Mood | Review |
| 36340786 | The above findings may provide supportive evidence for the hypotheses that acupuncture alterates the activity of the ACC, resulting in an alteration of the perception of nociceptive emotions triggered by headache pain. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Mood | Review |
| 36340786 | In addition to the instant and sustained effects, placebo effects were also shown through the insula, which may be through relieving emotional disorders using sham acupuncture. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Mood | Review |
| 36340786 | It is hoped that further studies should focus on the acupuncturing effects on amygdala activity and mechanisms focused on the rebuilding of DMN and limbic connections, which are likely to contribute to acupuncture in altering emotion-related impairment in migraine. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Mood | Review |
| 36340786 | Acupuncture has been discussed to have nonspecific modulation effects on a number of brain regions, implicated in the regulation of nociceptive perception and emotional disorders (e.g., anxiety and depression). | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Anxiety Depression Mood | Review |
| 36353235 | The effects of acupuncture for PCOS involved improvement in ovulation rate, pregnancy rate, insulin resistance, negative emotion, sexual hormone disturbance, and lipid metabolism dysfunction ( Figure 2 ). | Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. | Mood | Review |
| 36353235 | The effect of acupuncture on restoration of the hypothalamic-pituitary-ovarian (HPO) axis and amelioration of emotional disorders. | Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. | Mood | Review |
| 36353235 | To the best of our knowledge, this is the first detailed review to address acupuncture-specific action on PCOS-related symptoms, including ovulatory dysfunction, hyperandrogenism, insulin resistance, obesity, and emotional disorders. | Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. | Mood | Review |
| 36353235 | Secondly, the mechanisms of acupuncture on PCOS-related main symptoms (ovulatory dysfunction, hyperandrogenism, insulin resistance, obesity, and negative emotion) were all overviewed. | Front Endocrinol (Lausanne). 2022 Oct 24;13:1035929. doi: 10.3389/fendo.2022.1035929. eCollection 2022. | Mood | Review |
| 36408345 | With the advancement of studies on pain, these previous studies have found that acupuncture can ease the pain of patients and further regulate the negative emotions and cognition induced by pain. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood | Review |
| 36408345 | Acupuncture can effectively relieve pain itself and improve cognitive impairment and negative emotions and other complications. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood | Review |
| 36408345 | An fMRI study based on a mixed-effects model showed that immediate relief of chronic pain and negative emotions by acupuncture were associated with significant changes in spontaneous neural activity in the default network, basal ganglia region, and brain region where the limbic system is located, and NAc, especially in contrast to the spontaneous neural activity of chronic pain in the insular and bilateral occipital lobes. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood | Review |
| 36408345 | Considering that acupuncture also activates the reward loop in the brain of healthy subjects, these results suggest that the reward loop in the brain is a standard mechanism by which acupuncture modulates emotional disorders. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood | Review |
| 36408345 | A prior study has shown that electroacupuncture relieves emotional pain in an animal model of inflammatory pain involving the anterior cortical opioid peptide system. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood Inflammatory Pain | Review |
| 36408345 | In addition, electroacupuncture can activate the brain reward system and increase the 5-hydroxytryptamine (5-HT) level in the NAc of bound conscious rats, suggesting that acupuncture may be effective in the treatment of emotional disorders. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood | Review |
| 36408345 | Acupuncture can relieve pain and negative emotion simultaneously as analgesia. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood | Review |
| 36408345 | Acupuncture, including electroacupuncture, can significantly inhibit pain sensation with the immediate analgesic effect and improve pain-induced negative emotions, including anxiety and depression accompanied by pain and cognitive changes. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Analgesic Effect Anxiety Depression Mood | Review |
| 36408345 | We must deeply understand the similarities and differences between the reward learning process of acupuncture analgesia and the standard positive emotion learning process, which will provide necessary mechanism support for acupuncture treatment of patients with chronic pain. | Evid Based Complement Alternat Med. 2022 Nov 10;2022:3759181. doi: 10.1155/2022/3759181. eCollection 2022. | Mood | Review |
| 36570846 | Strengthening the connection between the AMG and the related nuclei in the PFC, hypothalamus, PAG, and VLM has been proposed to be the potential mechanism underlying the relief of pain-associated emotion by acupuncture, together with other therapeutic effects. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Pain Relief Mood | Review |
| 36570846 | Electroacupuncture at ST36 has also been shown to reduce neuroinflammation by downregulating the TRPV1-PERK signaling pathway in the mouse AMG, somatosensory cortex, and thalamus to attenuate acid saline injection-induced nociceptive hyperalgesia, suggesting that pain-related signaling pathways in the AMG are involved in acupuncture analgesia relieving pain-related emotions. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Mood | Review |
| 36570846 | These autonomic cortical regions form a complex pain regulatory network with autonomic nuclei related to descending inhibition systems such as PAG, RVM, NTS, and dorsal reticular nucleus to participate in acupuncture analgesia and alleviate pain-related emotion (Figure 1). | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Mood | Review |
| 36590302 | For instance, fMRI studies have demonstrated that acupuncture could achieve therapeutic effects by modulating a variety of brain networks in CP, such as the emotional response network (Kong et al.,; Liu et al.,), the default network (DMN) (Hou et al.,; Zou et al.,; Liu et al.,), the frontoparietal network (FPN) (Kong et al.,), etc. | Front Neurosci. 2022 Dec 14;16:1049887. doi: 10.3389/fnins.2022.1049887. eCollection 2022. | Mood | Review |
| 36590302 | The findings confirmed that acupuncture may produce the therapeutic effect on CP by modulating the brain regions associated with emotion and cognition. | Front Neurosci. 2022 Dec 14;16:1049887. doi: 10.3389/fnins.2022.1049887. eCollection 2022. | Mood | Review |
| 36590302 | In conjunction with the results of ALE, it showed that acupuncture could modulate the abnormal precuneus function in CP to achieve a smooth strip of emotional cognition. | Front Neurosci. 2022 Dec 14;16:1049887. doi: 10.3389/fnins.2022.1049887. eCollection 2022. | Mood | Review |
| 36704010 | In conclusion, for the sole purpose of relieving pain, the clinician should choose pricking and cupping plus antiepileptics, while PHN patients with negative emotions and insomnia should use electroacupuncture plus antiepileptics. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Insomnia Mood | Review |
| 36756246 | Acupuncture treatment can increase pain threshold, inhibit somatic pain, relieve acute and chronic pain, and reduce or even eliminate deep and involved pain along with emotional reactions to pain thereby improving patients' quality of life. | Front Neurol. 2023 Jan 23;14:1093849. doi: 10.3389/fneur.2023.1093849. eCollection 2023. | Mood | Review |
| 36778899 | Acupuncture could activate multiple brain areas related with the regulation of pain conduction, processing, emotion, cognition, and other brain regions in patients with migraine. | Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. | Mood | Review |
| 36778899 | Acupuncture could activate multiple brain areas related with the regulation of pain conduction, processing, emotion, cognition, and other brain regions in patients with migraine. | Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. | Mood | Review |
| 36823586 | Based on the ts-fMRI studies, nine neuroimaging studies reported that the activated brain areas after acupuncture concerned the processing of cognitive function, including the memory regions (e.g., the hippocampus, inferior frontal gyrus, superior frontal gyrus, and superior temporal gyrus), auditory speech area (e.g., the superior temporal gyrus, transverse temporal gyrus, and inferior parietal lobule), language function region (e.g., the middle frontal gyrus, middle temporal gyrus, and cerebellum), spatial attention region (e.g., the superior parietal lobule), affective-emotional processing areas of cognitive function (e.g., the insula, cingulate cortex, and thalamus), motor function region (e.g., the precentral gyrus), and sensory function region (e.g., the postcentral gyrus). | BMC Complement Med Ther. 2023 Feb 23;23(1):63. doi: 10.1186/s12906-023-03888-y. | Cognitive Function Mood Language Function Motor Function | Review |
| 36852393 | In comparison to moxibustion, acupuncture studies also found that the activation of the nociceptive modulation system in the brain also activated the limbic system associated with emotion and pain perception. | Pain Res Manag. 2023 Feb 18;2023:8307249. doi: 10.1155/2023/8307249. eCollection 2023. | Mood | Review |
| 36852393 | The limbic system is thought to be the system that processes motivational-emotional aspects, cognitive-evaluative aspects, and pain memory while mediating the analgesic effects of acupuncture. | Pain Res Manag. 2023 Feb 18;2023:8307249. doi: 10.1155/2023/8307249. eCollection 2023. | Analgesic Effect Mood | Review |
| 36875696 | In addition, two articles reported increased ReHo or ALFF after instant acupuncture in brain areas involved in the processing of cognitive function, including the memory regions (e.g., the parahippocampal gyrus, precuneus), affective-emotional processing areas of cognitive function (e.g., the cingulate cortex, thalamus), and executive/language function region (e.g., the middle frontal gyrus). | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Cognitive Function Mood Language Function | Review |
| 36950556 | It can be seen that the covered groups with the need to treat cancer pain by acupuncture mainly existed in women, and their negative emotions were mainly anxiety and depression. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Cancer Pain Anxiety Depression Mood | Review |
| 36950556 | Acupuncture plays a direct or indirect role in cancer pain management by increasing plasticity in the hippocampus and neural networks, reducing inflammation in the brain, and alleviating negative emotions. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Cancer Pain Mood | Review |
| 36968497 | In conclusion, acupuncture therapy can effectively treat IBS and modulate gastrointestinal symptoms and concomitant mood disorders in patients. | Front Neurosci. 2023 Mar 9;17:934341. doi: 10.3389/fnins.2023.934341. eCollection 2023. | Mood | Review |
| 36968499 | Consequently, acupuncture may restore ghrelin expression in FD, which indicates a potentially dual therapeutic role for mood disorders and mucosal inflammatory cell infiltration, therefore improving gastrointestinal motility. | Front Neurosci. 2023 Mar 8;17:1109510. doi: 10.3389/fnins.2023.1109510. eCollection 2023. | Mood | Review |
| 36970520 | The above study suggests that long-term acupuncture treatment may alleviate the painful symptoms of migraine by modulating the horn back modulation associated with pain and emotions. | Front Neurol. 2023 Mar 8;14:1036413. doi: 10.3389/fneur.2023.1036413. eCollection 2023. | Mood | Review |
| 36970520 | A fMRI study on the effects of acupuncture on pain-emotion-related brain regions in patients with cervical spondylosis showed that the functional connectivity of the patient's left corpus callosum to the insula was reduced after acupuncture. | Front Neurol. 2023 Mar 8;14:1036413. doi: 10.3389/fneur.2023.1036413. eCollection 2023. | Mood | Review |
| 37025199 | Sham acupuncture also induced greater activation in somatosensory, cognitive, and emotional brain regions. | Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. | Mood | Review |
| 37025199 | Acupuncture and moxibustion in the treatment of depression relieve depression and soothe the patient, which can promote emotional stability and peace of mind both physically and psychologically. | Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. | Depression Mood | Review |
| 37025199 | Studies have shown that electroacupuncture stimulation of the auricular thyroid vagus nerve can effectively treat mild to moderate depression in clinical practice, and its mechanism is regulation of the functional state of the vagus nerve, so as to change the emotion control center in the brain. | Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. | Depression Mood | Review |
| 37034090 | Through literature review of existing RCTs, the following acupuncture points are mainly selected in the treatment of PSD: Baihui point to awake the brain and open the body, calm the heart and calm the mind; Shenting point and Shenmen point to tonify Qi and calm the spirit; Taichong point and Neiguan point to calm the mind, calm the liver and calm the wind, so as to improve the mood of patients. | Front Neurol. 2023 Mar 23;14:979643. doi: 10.3389/fneur.2023.979643. eCollection 2023. | Mood | Review |
| 37046882 | In the study of Davies et al., self-administered acupuncture was recommended as an alternative coping skill for emotional distress in patients (n = 10) with emotionally unstable personality disorders with deliberate self-harm. | Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. | Mood | Review |
| 37221469 | Using RS fMRI, many studies demonstrated that, compared to controls, migraine patients experienced widespread functional alterations in brain areas implicated in the processing of the sensory-discriminative, cognitive, and emotional aspects of pain, which were reverted after acupuncture treatment. | J Headache Pain. 2023 May 24;24(1):58. doi: 10.1186/s10194-023-01590-5. | Mood | Review |
| 37360179 | This study found that acupuncture at ST36 activated the bilateral cerebellum, hemispheric lobule VIII, bilateral Rolandic operculum, and right supramarginal gyrus, suggesting that acupuncture at ST36 could be used to treat motor, cognitive, learning and memory, and emotion-related disorders. | Front Neurosci. 2023 Jun 9;17:1180434. doi: 10.3389/fnins.2023.1180434. eCollection 2023. | Learning and Memory Ability Mood | Review |
| 37363406 | A research team from Heilongjiang University of Chinese Medicine conducted electroacupuncture treatment on rats with GV20, emotional area I and bilateral sensory areas as the main acupoints in prescription and found that the morphological regularity and structural density of neurons in the hippocampus and hypothalamus area of rats with CFS were improved, and the inflammatory infiltration was reduced. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Mood | Review |
| 37363406 | treated CFS rats with electro-acupuncture on GV20, emotional area I and bilateral sensory areas, and found that the protein levels of NF- κB p65 and COX-2 in the hippocampus and hypothalamus areas was significantly reduced compared with those of the model group. | World J Acupunct Moxibustion. 2023 Mar 17. doi: 10.1016/j.wjam.2023.03.002. | Mood | Review |
| 37405111 | The effects of acupuncture on PCOS are related to sexual hormone regulation, improvement in ovulation and pregnancy rate, insulin resistance and lipid metabolism regulation as well as the rebalance of negative emotions. | J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. | Mood | Review |
| 37405111 | We also included information from the main databases for randomized (RCT) and non-randomized controlled trials (non-RCT) and attested to acupuncture efficacy in resolving the main symptoms of PCOS regarding endocrine, metabolic, and emotional features. | J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. | Endocrinology Mood | Review |
| 37405111 | Last but not least, when studying the effect of acupuncture intervention alone or in combination with other procedures on mental health issues related to PCOS, our review made it possible to infer that: 1) longer treatment period interventions seemed to worsen anxiety symptoms in the control groups; 2) a protocol of Shu points, such as BL18 and BL23 in combination with CV3, CV4, CV9 and CV12 was more effective addressing anxiety than protocols considering CV3 and CV6, plus stomach and spleen points and a few of sedative acupoints (GV20, PC6, and LR3); 3) a higher number of acupuncture sessions even performed for a shorter intervention period seemed to improve anxiety symptoms; 4) physiological decrease of serotonin and GABA, and an increase of norepinephrine after the active acupuncture treatment might be behind the positive effect on the psycho-emotional issues of women diagnosed with PCOS; and 5) a decrease of mental health status assessed through SF-36 could be attributed to several stress factors such as pressure for getting pregnant, external pressure of deadlines and diagnosis bureaucracy, lack of management time and resources to closely follow patients, which might lead to a sustained sympathetic activation of the nervous system that annuls the benefits of the acupuncture interventions. | J Pharmacopuncture. 2023 Jun 30;26(2):105-123. doi: 10.3831/KPI.2023.26.2.105. | Anxiety Mood | Review |
| 37510483 | A meta-analysis of 27 randomized controlled trials suggests that acupuncture treatment could ameliorate the symptoms of depression, quality of life, cognition, total mentation, behavior and mood, and activities of daily living in PD patients. | Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. | Depression Mood | Review |
| 37542321 | This systematic review and meta-analysis aimed to investigate the effect of acupuncture on the management of pain and mood disorders in patients with migraine. | BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. | Mood | Review |
| 37542321 | Since the purpose of this study was to investigate the effects of acupuncture on anxiety, depression and other emotional disorders in migraine patients, the main outcome indicators such as Pain-Related Mood Disorders (Zung Self-Rated Anxiety Scale (SAS), Zung Self-rating Depression Scale (SDS) and Short Form 36 Mental Health (MH) that can better reflect the improvement of mood were selected as the main outcome indicators. | BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. | Anxiety Depression Mood | Review |
| 37542321 | Although we focused more on mood disorders associated with migraines, pain and quality of life scores in migraine patients were also of concern, so we chose Visual Analog Scale (VAS) scores for acupuncture migraine and Migraine-Specific Quality of Life Questionnaire (MSQ) emotional Functioning Subscaleas secondary outcomes. | BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. | Mood | Review |
| 37542321 | However, because the sample size of the included literature is small and the doses of different drugs are inconsistent, the main observation indicators in this paper focus is on the psycho-emotional effects of acupuncture in patients with migraine. | BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. | Mood | Review |
| 37543780 | Scalp acupuncture (SA) can significantly improve somatic dysfunction and emotional disorder in stroke patients. | Medicine (Baltimore). 2023 Aug 4;102(31):e34561. doi: 10.1097/MD.0000000000034561. | Mood | Review |
| 37546517 | By regulating the balance of neurotransmitters, acupuncture can affect the neural circuits in the brain associated with mood regulation. | Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. | Mood | Review |
| 37568485 | Likewise, the reduction of constipation seemed to correlate with reductions in anxiety and depressive mood, as recorded with HADS after massages and aerobic and resistance training, and the self-rating anxiety scale and self-rating depression scale after electro-acupuncture stimulation at the Tiensu point. | J Clin Med. 2023 Aug 2;12(15):5083. doi: 10.3390/jcm12155083. | Anxiety Depression Mood | Review |
| 37614513 | A previous study had implied that acupuncture may ameliorate emotional depression by strengthening hippocampal neuroplasticity and attenuating inflammation in the brain. | Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. | Depression Mood | Review |
| 37644765 | Moreover, the acupuncture group demonstrated a relatively higher level of safety, contributing positively to the emotional well-being and quality of life of critically ill rehabilitation patients. | Libyan J Med. 2023 Dec;18(1):2251640. doi: 10.1080/19932820.2023.2251640. | Mood | Review |
| 37678839 | In the CNS, acupuncture regulates pain and its related emotions via different pathways that are mediated by different glutamate receptors. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Mood | Review |
| 37678839 | In addition, acupuncture inhibited the PKCzeta/PKMzeta-GluR1 pathway in ACC and up-regulated the NMDAR pathway in PFC, hippocampus and hypothalamus, relieving inflammatory pain-related adverse emotions. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Mood Inflammatory Pain | Review |
| 37678839 | Pain is often accompanied by different levels of pain emotions, and acupuncture can relieve pain and these bad emotions at the same time, which is also a feature of the mechanisms involved in acupuncture analgesia at the brain level. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Mood | Review |
| 37712096 | Although the complex mechanisms underlying acupuncture analgesia remain unclear, there is growing clinical evidence to suggest that acupuncture not only relieves the nociceptive experience of NP but also further modulates the negative emotions and cognitions caused by pain. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Mood | Review |
| 37712096 | The results showed that acupuncture could exert analgesic effects and regulate pain emotion and cognitive pain effects by affecting functional activities in different brain regions (e.g., synaptic plasticity, the release of different neurotransmitters), which explains the modulatory effects and mechanisms of acupuncture analgesia and further deepens the implication and extension of acupuncture analgesia. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect Mood | Review |
| 37712096 | In addition to the analgesic effects, acupuncture may improve neuropathic pain-induced mood/cognitive dysfunction by restoring overall DNA methylation in the PFC. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Analgesic Effect Neuropathic Pain Cognitive Function Mood | Review |
| 37712096 | One study investigated the intervention mechanism of different acupuncture methods on negative emotions in rats with neuropathic mirror pain, which may be related to the inhibition of proliferative activation of ACC microglia. | Front Neurosci. 2023 Aug 30;17:1243231. doi: 10.3389/fnins.2023.1243231. eCollection 2023. | Mood | Review |
| 37732301 | Furthermore, acupuncture can regulate the emotional components of IBS by targeting hypothalamic-pituitary-adrenal axis-related hormones and neurotransmitters via relevant brain nuclei, hence improving the IBS-induced VH response. | Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. | Mood | Review |
| 37732301 | Acupuncture can significantly relieve symptoms of gastrointestinal disorders (FGID) including IBS, and it is more effective than drugs in relieving the emotions of FGID patients. | Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. | Mood | Review |
| 37732301 | Acupuncture may improve IBS stress-induced visceral hypersensitivity and emotional comorbidity through the HPA axis | Front Neurosci. 2023 Sep 4;17:1251470. doi: 10.3389/fnins.2023.1251470. eCollection 2023. | Mood | Review |
| 37810368 | In 2018, ASCO proposed that acupuncture can be used to improve emotional disorders, anxiety, and depression in patients with breast cancer (level C). | Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. | Anxiety Depression Mood | Review |
| 37893778 | Acupuncture Treatment for Emotional Problems in Women with Infertility: A Systematic Review and Meta-Analysis | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | This systematic review and meta-analysis aimed to evaluate the efficacy and safety of acupuncture in treating emotional problems in women with infertility. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | We searched for randomized controlled trials using acupuncture treatment for emotional problems in women with infertility using 11 databases from their inception to 30 June 2023. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | Our findings demonstrate the potential of acupuncture for treating emotional problems in women with infertility. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | Acupuncture is a treatment that is widely used in oriental medicine to improve emotional problems. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | Previous studies have shown that acupuncture improves emotional problems such as anxiety, depression, and mental stress in unspecified people with mental problems; therefore, it is expected to be effective in improving emotional problems in women with infertility. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Anxiety Depression Mood | Review |
| 37893778 | Despite extensive research on the therapeutic effect of combining acupuncture and in vitro fertilization to improve pregnancy and implantation rates, the effect of acupuncture on emotional problems in women with infertility remains unclear. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | A systematic review of acupuncture treatment for emotional problems in women with infertility has been previously published; however, it only addressed anxiety among women with infertility, without exploring other emotional problems. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Anxiety Mood | Review |
| 37893778 | Therefore, we performed a systematic review and meta-analysis to evaluate the effectiveness and safety of acupuncture treatment for managing emotional problems in women with infertility. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | We included all randomized controlled trials (RCTs) that evaluated the effects of acupuncture treatment on emotional problems in women with infertility. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | Subsequently, the full texts of the 29 studies were reviewed, and 17 studies that did not meet the eligibility criteria were excluded: one that is not related to emotional problems of infertile women, two that did not use acupuncture as an intervention method, six review articles, two protocol articles, and five that were not RCTs. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | This systematic review examined the effectiveness and safety of acupuncture treatment in treating emotional problems in women with infertility. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | In all the included studies, the three most commonly used acupuncture points for treating emotional problems in women with infertility were PC6, ST36, and SP6. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | This study is meaningful because it evaluated the effectiveness and safety of acupuncture for emotional symptoms in women with infertility and provides a clinical basis for acupuncture treatment in women with infertility with emotional symptoms. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | However, the effect of acupuncture on emotional problems in women with infertility observed in this study needs to be confirmed by high-quality clinical studies. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Mood | Review |
| 37893778 | Our review and meta-analysis suggest that acupuncture may be an effective and safe treatment for emotional problems, particularly anxiety and depression, in women with infertility. | Healthcare (Basel). 2023 Oct 10;11(20):2704. doi: 10.3390/healthcare11202704. | Anxiety Depression Mood | Review |
| 37904453 | Overall, this study concluded that perioperative acupuncture using imbedded needles relieved early postoperative pain, improved emotional state and comfort, and promoted patient recovery. | Medicine (Baltimore). 2023 Oct 27;102(43):e35759. doi: 10.1097/MD.0000000000035759. | Mood | Review |
| 38027491 | Acupuncture has been shown to relieve visceral pain, depression, anxiety, and other negative emotions by regulating the functional activities of certain brain regions, including the regulation of receptor expression and neurotransmitter release, including serotonin and epinephrine (Figure 1). | Front Neurosci. 2023 Nov 1;17:1243232. doi: 10.3389/fnins.2023.1243232. eCollection 2023. | Visceral Pain Anxiety Depression Mood | Review |
| 38046594 | Numerous animal experiments and clinical studies suggest that acupuncture primarily intervenes in neuropathic pain through the sensory, emotional, cognitive, and social dimensions. | Front Neurol. 2023 Nov 16;14:1281485. doi: 10.3389/fneur.2023.1281485. eCollection 2023. | Neuropathic Pain Mood | Review |
| 38078016 | Acupuncture does not only provide analgesia by suppressing the sensation of pain, but it can also provide analgesia by intervening on emotions and cognitions (expectations) to relieve the sensation of pain. | J Pain Res. 2023 Dec 5;16:4165-4180. doi: 10.2147/JPR.S442151. eCollection 2023. | Mood | Review |
| 38200908 | Notably, electro-acupuncture was found to modulate brain activity and connectivity in regions associated with pain perception, emotional regulation, and cognitive processing. | Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. | Mood | Review |
| 38200908 | Electro-acupuncture for irritable bowel syndrome led to decreased activity in the anterior cingulate cortex, offering pain relief, while electro-acupuncture for obesity impacted brain regions associated with dietary inhibition and emotional regulation. | Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. | Pain Relief Mood | Review |
| 38200908 | In particular, fMRI studies have revealed that acupuncture can modulate brain activity and connectivity in areas associated with pain perception, emotion regulation, and cognitive processing. | Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. | Mood | Review |
| 38200908 | On the other hand, the long-term effect of electro-acupuncture resulted in significant improvements in weight, BMI, emotional eating, and food addiction. | Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. | Mood | Review |
| 38200908 | The specific mechanisms at play can vary depending on the condition and acupuncture methodology but often involve the modulation of pain perception, inflammation, and emotional regulation through alterations in brain connectivity and neurotransmitter levels. | Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. | Mood | Review |
| 38200908 | The findings suggest that electro-acupuncture can modulate neural pathways associated with pain perception, inflammation, emotional regulation, and homeostasis, contributing to symptom relief and improved clinical outcomes. | Healthcare (Basel). 2023 Dec 19;12(1):2. doi: 10.3390/healthcare12010002. | Mood | Review |
| 25047046 | Emotional, hormonal and affiliative responses to touch have already been assured. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Mood | Clinic |
| 21448381 | Thus, it's very important to take effective medical intervention for the mood preparation of patients before surgery. | J Res Med Sci. 2011 Jan;16(1):39-42. | Mood | Clinic |
| 23342207 | The International Association for the Study of Pain has proposed the following working definition: pain is 'an unpleasant sensory and emotional experience associated with either actual or potential tissue damage, or is described in terms of such damage.' Pain is a complex experience that results from physiological, sensory, affective, cognitive, and behavioral factors. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Mood | Clinic |
| 26170873 | The improvement in QoR scores in the TEAS group reflected improvements in the dimensions of emotional status (3 points), physical comfort (4.5 points), psychological support (3 points), physical independence (1 point), and postoperative pain (2.5 points). | Evid Based Complement Alternat Med. 2015;2015:324360. doi: 10.1155/2015/324360. Epub 2015 Jun 11. | Mood | Clinic |
| 27688791 | In the SF-36 survey for QoL, participants in the LR3 group reported the scores before acupuncture of physical functioning (PF, 85.71 xc2xb1 12.69), role physical (RP, 75.00 xc2xb1 36.69), bodily pain (BP, 79.07 xc2xb1 14.85), general health (GH, 50.64 xc2xb1 14.05), vitality (VI, 68.21 xc2xb1 18.57), social functioning (SF, 82.54 xc2xb1 15.54), role emotional (RE, 73.81 xc2xb1 35.03), and mental health (MH, 68.86 xc2xb1 14.98) and the scores after treatment of PF (84.29 xc2xb1 11.74), RP (76.78 xc2xb1 34.62), BP (80.14 xc2xb1 9.46), GH (52.50 xc2xb1 14.29), VI (67.86 xc2xb1 11.56), SF (89.68 xc2xb1 12.68), RE (76.19 xc2xb1 42.22), and MH (66.29 xc2xb1 15.51). | Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. | Blood Pressure Mood | Clinic |
| 27688791 | Frontal lobe closely associated with emotions and emotions had relationship with blood pressure. | Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. | Blood Pressure Mood | Clinic |
| 31915045 | These measure physical comfort, emotional state, physical independence, psychological support and pain. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Mood | Clinic |
| 34682857 | Because the vlPFC may be associated with the modulation of pain-related emotion, the decreased FC in the vlPFC may reflect a progressively weakening in affective pain modulation for menstrual pain. | J Clin Med. 2021 Oct 15;10(20):4731. doi: 10.3390/jcm10204731. | Mood | Clinic |
| 36098938 | This score measures the quality of a patientxe2x80x99s postoperative recovery in terms of changes in physical comfort, mood, physical independence, psychological support, and pain. | Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. | Mood | Clinic |
| 36749304 | For the SDS score, patients scored on the scale according to their emotional state. | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | Significant timexc2xa0xc3x97xc2xa0group interaction effects were found in pain intensity (mean reduction in NRS [Fxc2xa0=xc2xa015.634, pxc2xa0 |
Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | The MFG activity is implicated in pain stimulation and modulation, perception of negative emotions, and cognitive evaluation (Boissoneault etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | Deactivating the left IFGtriang is associated with response inhibition, as well cognitive and emotional dysregulation (Liu etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | Precuneus, a cortical element in the medial surface, is involved in attention, spatial integration, selfxe2x80x90awareness, psychological activities, social cognition, and emotional processing (Pereiraxe2x80x90Pedro & Bruner,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | The cuneus integrates somatosensory input with other sensory stimuli and cognitive processes, involving the emotion dimension of pain (Price,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | Emotion affects pain perception, and patients experiencing severe acute pain are more likely to develop a negative emotion, which in turn increases pain perception, thus forming a vicious circle (Michaelides & Zis,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | Temporal cortex participates in pain perception and modulation, as confirmed in human neuropathic states, and it is also closely related to emotional control and sensory process modulation, and pain sensation duration (Khoshnejad etxc2xa0al.,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 36749304 | The SDS score in EA group showed the patients receiving EA had a lower tendency to develop depression, which can be explained by the reduced pain severity and negative emotions after EA, and the resultant increase of the functional activities in the relevant brain regions. | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Depression Mood | Clinic |
| 36749304 | Another explanation is EA stimulation directly activates the relevant brain areas to regulate the adverse emotions and reduce the perception of acute pain. | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Mood | Clinic |
| 16565594 | This suggests that oriental acupuncture therapy may be effective for the treatment of emotional disorders, drug abuse and alcoholism. | Tohoku J Exp Med. 2006 Apr;208(4):321-6. doi: 10.1620/tjem.208.321. | Mood | Mechanism |
| 19733189 | Acupuncture with the manipulation of the needles according to traditional Chinese medicine or with the electrical stimulation applied on needles inserted into the acupoints (referred as electro-acupuncture, EA) may modulate stress response, mood, learning and memory process. | Physiol Behav. 2009 Dec 7;98(5):537-42. doi: 10.1016/j.physbeh.2009.08.011. Epub 2009 Sep 3. | Stress Response Learning and Memory Ability Mood | Mechanism |
| 8743718 | In the present study, we selected anesthetized animals as the subjects of this experiment in order to eliminate emotional factors, and investigated the responses to acupuncture stimulation at only a single point by changing animal conditions. | Jpn J Physiol. 1996 Feb;46(1):53-8. doi: 10.2170/jjphysiol.46.53. | Mood | Mechanism |
| 26419631 | NPY is a major neurotransmitter in the enteric plexus, and could affect cholinergic transmission in intestine mucous membrane inferior ganglion and regulate stress and mood by affecting hippocampus and hypothalamus. | BMC Complement Altern Med. 2015 Sep 29;15:340. doi: 10.1186/s12906-015-0863-5. | Mood | Mechanism |
| 37548586 | A growing body of clinical and basic research suggests that pain is closely associated with abnormalities in the function of neural structures involved in emotion and motivation (Liu,). | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Mood | Mechanism |
| 37548586 | Acupuncture can both reduce pain and improve the negative emotions associated with pain by modulating the brain's reward circuit (Zhang et al.,). | Brain Behav. 2023 Oct;13(10):e3177. doi: 10.1002/brb3.3177. Epub 2023 Aug 7. | Mood | Mechanism |
| 25282142 | A well-trained acupuncturist attempts to correct imbalances of the Qi and recover the equilibrium between physical, emotional and spiritual aspects of the individual by inserting needles into specific cutaneous points of the body. | BMC Complement Altern Med. 2014 Oct 5;14:375. doi: 10.1186/1472-6882-14-375. | Mood | Mechanism |
| 32796318 | Chronic pain reduces life quality and is an important clinical problem associated with emotional and cognitive dysfunction. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Mood | Mechanism |
| 32796318 | Acupuncture treatment for 6 months (3 days/week) improved mechanical/cold allodynia and the emotional/cognitive dysfunction caused by left partial sciatic nerve ligation (PSNL)-induced neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Cognitive Function Mood | Mechanism |
| 32796318 | Chronic pain, defined as persistent pain for at least 3 to 6 months, is associated with comorbidities, such as emotional and cognitive impairment, which further adversely affect quality of life. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Mood | Mechanism |
| 32796318 | Acupuncture, practiced for more than 2500 years in East Asia, has been used to treat chronic pain and emotional and cognitive disorders. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Mood | Mechanism |
| 32796318 | In this study, we investigated whether acupuncture improved allodynia, negative emotional states, and reduced cognitive capacity in mice 6 months after PSNL. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Mood | Mechanism |
| 32796318 | Acupuncture corrected persistent emotional disorders caused by partial sciatic nerve ligation | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Mood | Mechanism |
| 32796318 | We used OFT, EPM, and TST to examine the effects of acupuncture treatment on PSNL-induced emotional disorders. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Mood | Mechanism |
| 32796318 | Effects of acupuncture on emotional functions measured using the OFT, EPM, and TST. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Mood | Mechanism |
| 32796318 | Chronic neuropathic pain has multidimensional aspect from nociception to comorbid emotional and cognitive discomfort. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | Our results indicate that acupuncture improved nociceptive and emotional and cognitive impairment associated with PSNL-induced neuropathic pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | These results demonstrate the effect of acupuncture on DNA methylation in mediating the sensory, emotional, and cognitive impact of chronic neuropathic pain, and suggested molecular mechanism in the PFC. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | By contrast, acupuncture resulted in normalized emotional processing and cognitive function and allodynia. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Mood | Mechanism |
| 32796318 | Furthermore, reduction of gray matter in the PFC was associated with the appearance of emotional dysfunction in persistent neuropathic pain rats. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuropathic Pain Mood | Mechanism |
| 32796318 | In recent studies, DNA methylation in PFC decreased in mice with persistent pain and emotional and cognitive impairment, suggesting the importance of relationship between changes in DNA methylation in PFC and comorbidity by pain. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Mood | Mechanism |
| 32796318 | Moreover, restoration of DNA methylation levels in PFC by oral administration of S-adenosylmethionine, a methyl donor, improves emotional and cognitive functions impaired by spared nerve injury. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Cognitive Function Mood | Mechanism |
| 24886495 | The limbic system contains structures that are involved in emotion, memory and sensation. | BMC Complement Altern Med. 2014 May 31;14:178. doi: 10.1186/1472-6882-14-178. | Mood | Mechanism |
| 30089868 | The Diagnostic and Statistical Manual of Mental Disorder 5th edition (DSM-V) defines PTSD according to four distinct diagnostic symptom clusters: recurring memories of the traumatic event, avoidance, negative alterations in cognitions and mood, and alterations in arousal and reactivity. | Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. | Mood | Mechanism |
| 30089868 | Acupuncture administered at point HT7 has been found to relieve emotional problems, especially excessive anxiety and worry, and acupuncture at point HT8 has been reported to have therapeutic effects on mental disorders. | Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. | Anxiety Mood | Mechanism |
| 24980520 | Pain is considered both a sensation and an emotion, showing considerable complexity and subjectivity. | BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211. | Mood | Mechanism |
| 28358020 | The incidence of CAG arises from repeated lesions of gastric superficial mucosa induced by various endogenous and exogenous factors such as emotional stress, physicochemical factors and microbial infection. | Sci Rep. 2017 Mar 30;7:45580. doi: 10.1038/srep45580. | Mood | Mechanism |
| 24524846 | Acupuncture also has been reported to activate some brain structures such as the periaqueductal gray, nucleus raphe magnus, locus coeruleus, and arcuate nucleus that contribute to descending inhibitory modulation, as well as deactivate multiple limbic areas modulating pain emotion, such as insula and the anterior cingulate cortex. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Mood | Mechanism |
| 31600836 | Besides involvement in motor functions, these two nuclei also play a role in the regulation of emotional behavior, cognition, and autonomic functions. | J Comp Neurol. 2020 Apr;528(6):953-971. doi: 10.1002/cne.24789. Epub 2019 Nov 12. | Mood Motor Function | Mechanism |
| 31600836 | The amygdala is a primary structure of the central autonomic network in addition to playing a role in modulation of emotional responses. | J Comp Neurol. 2020 Apr;528(6):953-971. doi: 10.1002/cne.24789. Epub 2019 Nov 12. | Mood | Mechanism |
| 21695393 | Pain has both sensory-discriminative and emotional-affective dimensions. | Neurochem Res. 2011 Nov;36(11):2104-10. doi: 10.1007/s11064-011-0534-y. Epub 2011 Jun 22. | Mood | Mechanism |
| 21695393 | These data and our own show that acupuncture may modulate mood disorders induced by a variety of factors. | Neurochem Res. 2011 Nov;36(11):2104-10. doi: 10.1007/s11064-011-0534-y. Epub 2011 Jun 22. | Mood | Mechanism |
| 21695393 | The reciprocal effect between persistent pain and mood disorders is an extremely important issue given the prevalence of co-morbid emotional disorders in patients with chronic pain. | Neurochem Res. 2011 Nov;36(11):2104-10. doi: 10.1007/s11064-011-0534-y. Epub 2011 Jun 22. | Mood | Mechanism |
| 21695393 | low-frequency EA, for the treatment of both the sensory-discriminative and the emotional-affective dimensions of pain. | Neurochem Res. 2011 Nov;36(11):2104-10. doi: 10.1007/s11064-011-0534-y. Epub 2011 Jun 22. | Mood | Mechanism |
| 33384922 | The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma1 receptor involvement | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Mood | Mechanism |
| 33384922 | Then, ETOH-induced immobility was evaluated in an open field arena, ultrasonic vocalizations (USVs) indicating ethanol-induced emotional changes were recorded in a recording chamber, and the rats were sacrificed for the analysis of protein levels of Ï1 R in several regions of the brain. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Mood | Mechanism |
| 33384922 | Ultrasonic vocalizations (USVs) emitted by rats are considered to be a reflection of their real-time emotional state and are widely accepted as animal models of affect. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Mood | Mechanism |
| 33384922 | In the acute ETOH model, studies have focused on behavioral changes such as locomotor activity and FST, but few studies have evaluated the changes in real-time emotional state through USV analysis. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Mood | Mechanism |
| 33384922 | This present study aimed to investigate whether acupuncture at HT7 and treatment with the selective Sigma1 R antagonist BD 1047 would (1) block ethanol-induced immobility, (2) attenuate ethanol-induced negative or positive emotional states, and (3) regulate the ethanol-induced increases in protein levels of Sigma1 R in several regions of the rat brain. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Mood | Mechanism |
| 33384922 | This result represents a novel finding that the acute injection of ETOH induces negative emotions associated with abnormal mobility. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Mood | Mechanism |
| 33384922 | In summary, the previous results have suggested that (1) immobility is a reaction due to the effects of acute ETOH administration, (2) 22-kHz USVs reflect negative emotional responses caused by acute ETOH and (3) Sigma1 R is activated by acute ETOH. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Mood | Mechanism |
| 27978835 | Pain is characterized as a multidimensional experience, involving nociception, emotional, and cognitive aspects. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Mood | Mechanism |
| 27978835 | The hippocampus, a major component of the limbic system, has been shown to contribute to pain-related memory and emotional disorders. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Mood | Mechanism |
| 27978835 | These unique hippocampal disruptions are specific cellular correlation of the observed cognitive and emotional problems seen both in animal models of chronic pain and human patients with pain. | BMC Complement Altern Med. 2016 Dec 15;16(1):517. doi: 10.1186/s12906-016-1508-z. | Mood | Mechanism |
| 31217804 | Previous preclinical and clinical studies reported that some brain regions exhibited atypical functional connectivity in migraineurs and migraine model rats, including somatosensory pain processing (somatosensory cortex and posterior insula), emotional processing (anterior insula, anterior cingulate cortex, and amygdala), cognitive components and memories of pain processing (hippocampus and parahippocampal gyrus), and pain modulation (periaqueductal grey). | Evid Based Complement Alternat Med. 2019 May 14;2019:9512875. doi: 10.1155/2019/9512875. eCollection 2019. | Mood | Mechanism |
| 31217804 | In future studies, we will evaluate the effects of EA on the memory and emotional processing of pain. | Evid Based Complement Alternat Med. 2019 May 14;2019:9512875. doi: 10.1155/2019/9512875. eCollection 2019. | Mood | Mechanism |
| 30151295 | Major depressive disorder is a common and is characterized by various symptoms, such as depressed or irritable mood, decreased interest in activities, inability to experience pleasure, loss of appetite, sleep disturbances, and inappropriate feelings of guilt and worthlessness. | J Pharmacopuncture. 2017 Dec;20(4):257-264. doi: 10.3831/KPI.2017.20.031. Epub 2017 Sep 25. | Insomnia Mood | Mechanism |
| 34472492 | The results may indicate that β-EP in the midbrain PAG contributes to the rewarding and emotional effects of nicotine, which is consistent with some other studies (Berrendero et al., 2010; Gudehithlu et al., 2012). | Neural Regen Res. 2022 Apr;17(4):905-910. doi: 10.4103/1673-5374.322477. | Mood | Mechanism |
| 28672928 | Such negative emotions as tension, worry, fear, depression and anxiety; and social environment, diet, daily life and movement conditions are external factors. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Anxiety Depression Mood | Mechanism |
| 25861363 | At least 1/3 stroke survivors have varying degrees of emotional symptoms. | Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. | Mood | Mechanism |
| 37066940 | Our previous studies confirmed that PTSD model rats showed significant emotional disturbances, such as anxiety, depression, and fear, as well as obvious declines in learning and memory. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Learning and Memory Ability Anxiety Depression Mood | Mechanism |
| 28852400 | As a part of the prefrontal cortex, the orbital cortex is considered of vital importance in the control of emotions. | Neural Regen Res. 2017 Jul;12(7):1159-1165. doi: 10.4103/1673-5374.211197. | Mood | Mechanism |
| 25206746 | Chronic stress presents macroscopic changes in psychoactivity, causing stress-related mood disorders. | Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. | Mood | Mechanism |
| 25206746 | The hippocampus is a brain region closely associated with learning and memory abilities and emotion. | Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. | Learning and Memory Ability Mood | Mechanism |
| 34621320 | Regardless of the type of imaging study, results have consistently shown that the insula, a brain region in the deep cerebral hemisphere involved in processing emotional responses, visceral sensation, interoceptive awareness, cognitive and affective regulatory functions, and olfactory and gustatory stimulation processing, is an important area in FD research, since it is involved in both the pathogenesis and treatment of FD. | Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. | Mood | Mechanism |
| 34621320 | in their neural pattern study was that the temporal pole was related to the neuropsychological mechanism of emotion in FD patients and that patients with different disease durations could exhibit differing activity in this region. | Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. | Mood | Mechanism |
| 28806763 | However, most of the current anti-obesity drugs and therapies have failed to achieve adequate weight control in patients, due to side effects such as mood changes, suicidal thoughts, and gastrointestinal and cardiovascular complications. | PLoS One. 2017 Aug 14;12(8):e0181948. doi: 10.1371/journal.pone.0181948. eCollection 2017. | Cardiovascular Side Effects Mood | Mechanism |
| 37096024 | Hippocampus plays an important role in the limbic system, which is involved in physiological processes such as the formation and regulation of emotions and the formation of learning and memory. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability Mood | Mechanism |
| 37096024 | Serotonin, an important neurotransmitter and endogenous active substance, is critically involved in brain development and innervates the entire central nervous system, which allows serotonin to affect diverse physiological processes, including the sleep-wake cycle, learning and memory, mood, and aggression. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Learning and Memory Ability Mood | Mechanism |
| 37096024 | The combined effects of genetic factors, immune disorders, environmental factors and adverse factors during pregnancy, such as exposure to second-hand smoke, certain drugs and adverse emotions are considered to be closely related to the onset of autism. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Immunity Mood | Mechanism |
| 24527041 | Acupuncture Stimulation Attenuates Impaired Emotional-Like Behaviors and Activation of the Noradrenergic System during Protracted Abstinence following Chronic Morphine Exposure in Rats | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | Accordingly, the abuse of morphine and subsequent withdrawal from it result in an aversive emotional state and debilitating physical symptoms including restlessness, high emotionality, and lowered mood. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | Many studies have demonstrated that protracted morphine abstinence following spontaneous withdrawal causes emotion-related disorders in humans and corresponding behavioral responses in animals. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | In traditional oriental medicine, one of the most commonly used acupuncture points used for gynecological, fertility, digestive, urinary, sexual, and emotional disorders is SP6, or spleen 6. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Gastrointestinal Tract Mood | Mechanism |
| 24527041 | Conversely, depressed mood may contribute to drug abuse in accord with a self-medication hypothesis. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | The observed immobility behavior by rats in the FST is analogous to a state of lowered mood or helplessness and depression in humans. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Depression Mood | Mechanism |
| 24527041 | Although the FST provides information about mood (i.e., depression and anxiety) in rodents, it is important to use caution when extrapolating the data to humans. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Anxiety Depression Mood | Mechanism |
| 24527041 | In inescapable situations, immobility reflects a passive coping strategy associated with resignation, which is a behavioral measure of emotional despair. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | Moreover, BDNF is a central neurotrophic factor related to critical CNS functions and is important in the control of mood, emotion, and cognition. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | Acupuncture may exert its effects by influencing central noradrenergic pathways which support emotional states. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | Furthermore, acupuncture may also stimulate sensory nerves, induce the release of endogenous opioids, modulate autonomic nervous system activity and perhaps influence other hormones that medicate mood. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Mood | Mechanism |
| 24527041 | These results demonstrate that acupuncture stimulation of SP6 reduces the depression- and anxiety-like symptoms strongly associated with morphine abstinence, probably by modulating hypothalamic CRF and the noradrenergic system that underlies mood disruption. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Anxiety Depression Mood | Mechanism |
| 29033603 | To imitate the protrusion of lumbar intervertebral disc, the SNL model was generated by ligation of L5 spinal nerve to study pain-related emotion or pain memory. | J Pain Res. 2017 Sep 19;10:2271-2280. doi: 10.2147/JPR.S139324. eCollection 2017. | Mood | Mechanism |
| 28672900 | Acupuncture, particularly electro-acupuncture (EA), has been approved worldwide to be effective for pain or emotional problems. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Mood | Mechanism |
| 28672900 | It also has an important role in the induction and manipulation of emotional disorders. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Mood | Mechanism |
| 28672900 | Studies have shown that the serotonergic system in DRN has a role in the effects of EA on pain or emotional disorders. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Mood | Mechanism |
| 28672900 | Behavioral tests of depression and associated emotional disorders | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Depression Mood | Mechanism |
| 28672900 | Emotional behavior was quantified using the OF test and EZM test, which are generally used to evaluate depression and anxiety. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Anxiety Depression Mood | Mechanism |
| 28672900 | Pain-depression dyad is a complex illness with symptoms of pain overlapping with emotional disorders such as depression and anxiety. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Anxiety Depression Mood | Mechanism |
| 28672900 | 5-HT has an important role in the central nervous system in the descending control of pain or emotion. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Mood | Mechanism |
| 28672900 | Acupuncture, particularly EA, is commonly used for pain or emotional problems. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Mood | Mechanism |
| 20981331 | Recently, AC has been administrated in assisted reproductive technology to enhance the success of in vitro fertilization (IVF) treatment, due to the relatively low success rate of IVF per cycle, as well as the high emotional and financial costs. | Evid Based Complement Alternat Med. 2011;2011:606514. doi: 10.1155/2011/606514. Epub 2010 Sep 30. | Mood | Mechanism |
| 25878596 | Cerebral hemorrhage is often induced by exertion and emotion, and most patients show sudden onset during activity. | Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. | Bleeding Mood | Mechanism |
| 37383281 | Some patients also have anxiety, depression, and other negative psychological emotions. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Anxiety Depression Mood | Mechanism |
| 37383281 | In conclusion, acupuncture at Back-Shu acupoints improved cognitive behavioral changes and emotional disturbances caused by insomnia. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia Mood | Mechanism |
| 37383281 | In conclusion, the results show that acupuncture at the Back-Shu point can improve the cognitive behavior changes and emotional disorders caused by insomnia, improve learning and memory ability in rats, and promote learning and memory function recovery. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia Learning and Memory Ability Mood | Mechanism |
| 37383281 | The characteristics of insomnia are dissatisfaction with sleep, including difficulty beginning or maintaining sleep, waking up with/or early morning, accompanied by related daytime damage, such as fatigue and emotional disorders. | World J Psychiatry. 2023 Jun 19;13(6):340-350. doi: 10.5498/wjp.v13.i6.340. eCollection 2023 Jun 19. | Insomnia Mood | Mechanism |
| 18830456 | In the study of gastric-acid secretion, there are many factors apart from anesthetization such as emotions and hormones. | Evid Based Complement Alternat Med. 2008 Sep;5(3):251-6. doi: 10.1093/ecam/nem077. | Mood | Mechanism |
| 31737064 | Accumulating evidence has shown that CRF, which is mainly produced in the hypothalamic paraventricular nucleus, can induce altered bowel habits, visceral hypersensitivity, and emotional disorders, such as anxiety-like or depression-like behaviours, by combining with central CRF-R1. | Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. | Anxiety Depression Mood | Mechanism |
| 31737064 | It is pointed out in Rome IV Standards of Functional Gastrointestinal Disorders that IBS is the disorder of gut-brain interaction, further elaborating the importance of the interinfluence between intestinal and emotional symptoms in IBS. | Gastroenterol Res Pract. 2019 Oct 13;2019:1759842. doi: 10.1155/2019/1759842. eCollection 2019. | Mood | Mechanism |
| 33229729 | In addition, the early occurrence of non-cognitive and behavioral symptoms in prodromal AD, such as depression and general disturbances in mood (Chen et al., 2000; Wu et al., 2003), suggests the involvement of the DRN in AD. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Depression Mood | Mechanism |
| 31785199 | Depression is a major mood disorder. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Depression Mood | Mechanism |
| 31785199 | Depression is a mood disorder characterized by a persistent depressed mood, a feeling of helplessness, and can be associated with anxiety. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Anxiety Depression Mood | Mechanism |
| 26998388 | Panax ginseng (Radix ginseng) has been traditionally used as an adaptogen acting on the adrenal cortex and stimulating or relaxing the nervous system to restore emotional and physical balance and to improve well-being under degenerative conditions and in old age. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Mood | Mechanism |
| 37179843 | The information processing way of neuronal cells is the dynamic process in response to emotional changes, injury, external stimulators, and so forth. | Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. | Mood | Mechanism |
| 37179843 | The functional synapses in the central nervous system were disarranged in depression patients by emotional disorder and stress. | Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. | Depression Mood | Mechanism |
| 26770252 | In humans, patients with persistent pain frequently suffer from a series of aversive emotions including anxiety, fear, depression, loneliness, and misanthropy, which can be more distressing than the pain itself. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Anxiety Depression Mood | Mechanism |
| 26770252 | In last decades, preclinical and clinical researches have demonstrated that MA and EA are, respectively, effective for neuropathic pain and anxiety; however, it is unknown whether they have an effective role for neuropathic pain-induced negative mood. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Neuropathic Pain Anxiety Mood | Mechanism |
| 26770252 | Therefore, it is important to determine the functional significance of changes in the ACC when studying persistent pain-induced anxiety and other mood disorders. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Anxiety Mood | Mechanism |
| 26770252 | Extensive studies supported the notion that the ACC is a pivotal region for emotion. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Mood | Mechanism |
| 26770252 | A previous report suggested that ERK cascades in the ACC are involved in pain-induced negative emotion in the rat. | Evid Based Complement Alternat Med. 2015;2015:235491. doi: 10.1155/2015/235491. Epub 2015 Dec 3. | Mood | Mechanism |
| 34039946 | Many clinical studies and animal experiments have found that emotional responses are significantly correlated with changes in intestinal flora. | Med Sci Monit. 2021 May 27;27:e929027. doi: 10.12659/MSM.929027. | Mood | Mechanism |
| 36277498 | Trigeminal neuralgia (TN), one of the most severe and debilitating chronic pain conditions, is often accompanied by mood disorders, such as anxiety and depression. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuralgia Anxiety Depression Mood | Mechanism |
| 36277498 | TN is a chronic neuropathic pain which often causes mood disorders, such as anxiety and depression. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Neuropathic Pain Anxiety Depression Mood | Mechanism |
| 36277498 | The negative emotions induced by chronic pain can further exacerbate the pain sensation. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Mood | Mechanism |
| 36277498 | Thus, psychological therapies to improve mood disorders may be valuable adjuncts to pain management. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Mood | Mechanism |
| 36277498 | In recent years, EA has been widely used in the clinical treatment of TN and TN-related emotional disorders. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Mood | Mechanism |
| 36277498 | The main function of Hippocampal is to receive complex comprehensive sensory and cognitive information, and it is one of the core regions processing pain, emotion, cognition, and memory signals. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Mood | Mechanism |
| 36277498 | In chronic pain and abnormal emotional conditions, dysfunction in the CA1 region of the hippocampus, including fewer mature functional neurons, altered synaptic conformation and resting-state connectivity, abnormal expression of inflammatory cytokines and neurotrophic factors, reduced 5-hydroxytryptamine activity, and impaired glutamate transport metabolism, leads to impairments in synaptic plasticity. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Mood | Mechanism |
| 36277498 | Chronic pain can cause emotional disturbances like anxiety, depression, and fear in affected patients. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Anxiety Depression Mood | Mechanism |
| 36277498 | Thus, it adds to the probability of inducing mood disorders, including anxiety and depression. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Anxiety Depression Mood | Mechanism |
| 36277498 | Studies have demonstrated that EA has an analgesic effect on chronic pain and can modulate mood changes and cognitive dysfunction through central and peripheral mechanisms. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Analgesic Effect Cognitive Function Mood | Mechanism |
| 36277498 | The present study evaluated the anxiolytic effects of EA on TN-induced emotional disorders and explored its mechanism with respect to the hippocampal synaptic plasticity for the first time. | Front Mol Neurosci. 2022 Oct 6;15:979483. doi: 10.3389/fnmol.2022.979483. eCollection 2022. | Mood | Mechanism |
| 25206816 | Magnetic resonance imaging and functional magnetic resonance imaging revealed that heroin could activate brain areas regulating craving-related reward, learning and memory, cognition and emotion, but acupuncture at Zusanli suppressed the activation of craving-related brain areas. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Learning and Memory Ability Mood | Mechanism |
| 34393735 | Depression is a mood disorder characterized by disordered affect, thoughts, cognition, and behavior. | Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. | Depression Mood | Mechanism |
| 34393735 | Depression is a mood disorder characterized by disordered affect, thoughts, cognition, and behavior. | Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. | Depression Mood | Mechanism |
| 34393735 | NT-3 is thought to play a role in the neurobiological processes associated with mood and anxiety disorders. | Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. | Anxiety Mood | Mechanism |
| 34393735 | In recent years, it has been proposed that NT-3 is a potential pharmacological target for mood disorders due to its effects on monoamine neurotransmitters, regulation of synaptic plasticity and neurogenesis, enhancement of BDNF signaling, and regulation of the HPA axis. | Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. | Mood | Mechanism |
| 29636708 | Mood states, quality of feces, and appetite of rats were also observed and recorded. | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Mood | Mechanism |
| 29636708 | The findings for association of BMI in key white matter (WM) tracts that are crucial to mood regulation and neurocognitive functioning has suggested that BMI might contribute to the pathophysiology of bipolar disorder (BD) through a detrimental action on structural connectivity in critical cortico-limbic networks. | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Cognitive Function Mood | Mechanism |
| 29636708 | Interestingly, significant differences was found in ameliorating ahedonia (the core symptom of depression) and mood between fluoxetine and acupuncture, suggesting the comprehensively antidepressant response of acupuncture. | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Depression Mood | Mechanism |
| 29636708 | Such an antidepressant effect of acupuncture was evidenced by downregulating the expression level of HDAC2, thereby promoting the expression level of acH3K9, and elevating the expression levels of BNNF mRNA and protein, and finally restoring mood. | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Mood | Mechanism |
| 29636708 | Notably, we have also investigated that acupuncture could attenuate the expression level of HDAC2, then elevate the expression level of acH3K9, and the expression levels of BNNF mRNA and protein, and ultimately restore mood (Figures 4H,I). | Front Psychiatry. 2018 Mar 27;9:102. doi: 10.3389/fpsyt.2018.00102. eCollection 2018. | Mood | Mechanism |
| 23737830 | In clinical situations, acupuncture or EA may cause deqi sensations characterized by aching, pressure, heaviness, and numbness but not negative emotions such as sharp pain. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Mood | Mechanism |
| 23737830 | Emotional stress could be easily avoided in humans with sufficient verbal communications and habituation. | Evid Based Complement Alternat Med. 2013;2013:404956. doi: 10.1155/2013/404956. Epub 2013 May 12. | Mood | Mechanism |
| 29946236 | Also, animal studies demonstrate that chronic stress can lead to elevated IL-1β in several brain regions, including the hippocampus, a key area implicated in the stress response and responsible for memory and emotion (Liu et al.,; Pan et al.,). | Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. | Stress Response Mood | Mechanism |
| 25530777 | Depression is a kind of emotional disorder disease, characterized by low mood, body discomfort, and sleep disorders. | Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. | Depression Mood | Mechanism |
| 25530777 | The features mentioned indicate that Gal takes part in regulating many physiological functions and may be connected with cognition, emotional behavior, and other advanced physiological functions. | Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. | Mood | Mechanism |
| 25530777 | The hippocampus is closely related to learning, memorizing, behavior, and emotion. | Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. | Mood | Mechanism |
| 27843474 | Migraine is a common and complex brain disorder with significant morbidity, for example, autonomic, cognitive, emotional, and motor disturbance. | Evid Based Complement Alternat Med. 2016;2016:1846296. doi: 10.1155/2016/1846296. Epub 2016 Oct 24. | Mood | Mechanism |