- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Body System Protection
- Brain Protection
- Acupuncture anesthesia plays a vital role in brain surgeries, ensuring precise and safe anesthesia, reducing the risk of neurological complications, and supporting optimal cognitive function.
- Lung Protection
- Acupuncture anesthesia reduces post-operative lung complications, aiding in rapid lung function recovery, particularly beneficial for lung surgeries.
- Neuroprotection
- Acupuncture anesthesia is crucial for safeguarding the nervous system, reducing nerve injuries, and preventing the progression of neurological disorders.
- Kidney
- Acupuncture anesthesia alleviates stress on the kidneys, reducing the risk of kidney injury, particularly valuable in kidney surgeries.
- Gastrointestinal Tract
- Acupuncture anesthesia supports gastrointestinal health, reducing the risk of post-operative digestive issues, and ensuring a smoother recovery.
- Cardiovascular
- Acupuncture anesthesia eases the cardiovascular system's burden, reducing the risk of cardiovascular complications, especially in cardiac surgeries.
- Myocardium
- Acupuncture anesthesia aids in protecting the myocardium, minimizing adverse effects on heart muscle, ensuring cardiac health.
- Cognitive Function
- Through emotional stability and neuroprotection, acupuncture anesthesia helps preserve cognitive function, reducing the risk of post-operative cognitive impairment.
- Motor Function
- Acupuncture anesthesia improves motor function, aiding in post-operative mobility, and enhancing overall quality of life.
- Language Function
- Acupuncture anesthesia supports language function rehabilitation, assisting patients in regaining their communication skills.
- Learning and Memory Ability
- Acupuncture anesthesia, by reducing post-operative pain and emotional instability, enhances learning and memory ability, promoting a speedy recovery.
Acupuncture anesthesia for Body System Protection-Neuroprotection
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 17264834 | Vagal nerve stimulation and electroacupuncture have some promise as neuroprotective therapies for patients with poorly controlled epilepsy. | Acupunct Med. 2006 Dec;24(4):164-8. doi: 10.1136/aim.24.4.164. | Neuroprotection | Review |
| 17264834 | Taken together with laboratory findings, the neuroprotective pathways of electroacupuncture in epileptic models may stem from the collaboration of its anti-inflammatory and neurotrophic actions through the nucleus of the solitary tract via vagus nerve stimulation. | Acupunct Med. 2006 Dec;24(4):164-8. doi: 10.1136/aim.24.4.164. | Neuroprotection | Review |
| 20034437 | RESULTS: Acupuncture treatments in animal experiments have generated valuable mechanistic insights of Parkinson's disease and shown that acupuncture therapy is in fact a neuroprotective therapy which increases various neuroprotective agents such as brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor and cyclophilin A. In addition, acupuncture therapy decreases cell death processes and attenuates oxidative stress to substantia nigra dopaminergic neurons. | Neurol Res. 2010 Feb;32 Suppl 1:5-9. doi: 10.1179/016164109X12537002793643. | Neuroprotection | Review |
| 24215921 | We showed that acupuncture stimulation in Parkinson's models had generated valuable mechanistic insight of Parkinson's and showed that acupuncture treatment is in fact a neuroprotective therapy that increase the release of various neuroprotective agents such as brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, and cyclophilin A. In addition, acupuncture therapy slows cell death process and attenuates oxidative stress to dopaminergic neurons in the substantia nigra. | Int Rev Neurobiol. 2013;111:141-58. doi: 10.1016/B978-0-12-411545-3.00007-9. | Neuroprotection | Review |
| 30707414 | The results showed that the therapeutic effect of acupuncture on nerve injury focused on the anti-oxidation pathway, neuroprotective and anti-inflammatory processes. | Chin J Integr Med. 2020 Apr;26(4):310-320. doi: 10.1007/s11655-019-3150-3. Epub 2019 Feb 1. | Neuroprotection | Review |
| 24407111 | Here we review recent research progress in the mechanisms and clinical implications of non-pharmaceutical therapies, mainly including neuroprotective approaches such as hypothermia, ischemic/hypoxic conditioning, acupuncture, medical gases, transcranial laser therapy, etc. | Prog Neurobiol. 2014 Apr;115:246-69. doi: 10.1016/j.pneurobio.2013.12.007. Epub 2014 Jan 7. | Neuroprotection Hypothermia | Review |
| 24407111 | Among them, DOR appears to play a unique role as an acupuncture-induced neuroprotective protein against cerebral ischemia. | Prog Neurobiol. 2014 Apr;115:246-69. doi: 10.1016/j.pneurobio.2013.12.007. Epub 2014 Jan 7. | Neuroprotection | Review |
| 24407111 | Though acupuncture may influence several neurotransmitters/modulators and accordingly regulate various survival/death signals, the DOR-mediated survival pathway may play a critical role in acupuncture-induced neuroprotection against ischemic brain injury. | Prog Neurobiol. 2014 Apr;115:246-69. doi: 10.1016/j.pneurobio.2013.12.007. Epub 2014 Jan 7. | Neuroprotection | Review |
| 24407111 | Indeed, such DOR-mediated regulation is important for acupuncture to confer the neuroprotective effect because intracerebroventricular or intravenous injection of Naltrindole, a DOR agonist, largely reverses the EA-induced protection against ischemic brain injury. | Prog Neurobiol. 2014 Apr;115:246-69. doi: 10.1016/j.pneurobio.2013.12.007. Epub 2014 Jan 7. | Neuroprotection | Review |
| 24407111 | We argue that improved preclinical research will help to establish the basic biology behind neuroprotection afforded by acupuncture as well as delineate therapeutic paradigms to improve standardization into clinical practice. | Prog Neurobiol. 2014 Apr;115:246-69. doi: 10.1016/j.pneurobio.2013.12.007. Epub 2014 Jan 7. | Neuroprotection | Review |
| 24566146 | The Neuroprotective Role of Acupuncture and Activation of the BDNF Signaling Pathway | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | Recent studies have been conducted to examine the neuroprotective effects of acupuncture in many neurological disorders. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | Although the neuroprotective effects of acupuncture has been linked to changes in signaling pathways, accumulating evidence suggest the participation of endogenous biological mediators, such as the neurotrophin (NT) family of proteins, specifically, the brain derived neurotrophic factor (BDNF). | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | The purpose of this article is to review the recent findings and ongoing studies on the neuroprotective roles of acupuncture and therapeutic implications of acupuncture-induced activation of BDNF and its signaling pathway. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | Moreover, several recent studies have demonstrated neuroprotective activities of acupuncture therapy. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | For instance, it has been found that acupuncture-mediated neuroprotection can decrease p38MAPK levels and reduce the expression of pro-inflammatory cytokines/mediators and pro nerve growth factor (NGF), which are involved in apoptotic cell death of neurons and oligodendrocytes. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | In contrast, there are but a few studies which implicated the role of neurotrophins (e.g., BDNF, GDNF) in acupuncture-induced neuroprotection. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | The purpose of this article is to review the recent findings and ongoing studies on the neuroprotective roles of acupuncture and therapeutic implications of acupuncture-induced activation of BDNF and its signaling pathway. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | The Neuroprotective Effects of Acupuncture in Brain Function | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | Acupuncture treatments in animal experiments have generated valuable mechanistic insights into the pathology of PD and have provided evidence that acupuncture therapy is neuroprotective and can increase various neuroprotective agents such as BDNF, GDNF, and cyclophilin A (CypA). | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | For example, acupuncture can exert beneficial effects in the CNS by enhancing BDNF mRNA expression levels in the hippocampus of mice following cerebral ischemia-reperfusion injury, which protects neurons from injuries, and inhibits apoptosis of hippocampal cells. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | Some researchers believe that acupuncture can exert neuroprotective function in ischemic stroke via activation of the PI3K/Akt pathway. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | Acupuncture or ear acupressure has also been shown to protect patients from blindness, and the potential mechanism may be related with the neuroprotection via regulation of NGF and BDNF and their receptors. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | It has been reported that acupuncture can promote the expression of BDNF, and recent studies demonstrate that BDNF can protect neurons both in vitro and in vivo against various insults. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | At the same time, acupuncture also plays a critical role in neuroprotection. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | In light of evidence obtained from several animal studies, acupuncture-induced increase in endothelial BDNF exerted neuroprotection after nervous lesion. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 24566146 | BDNF and the neurotrophin family of proteins, which play a critical role in acupuncture-induced neuroprotection, will provide important insights into the nature of acupuncture. | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Neuroprotection | Review |
| 25097658 | Furthermore, acupuncture-induced dopaminergic neuron protection and motor function improvement were significantly blocked by administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway. | Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. | Neuroprotection Motor Function | Review |
| 25097658 | These results concluded that neuroprotection by acupuncture treatment comes from the collaboration of its anti-inflammatory actions. | Evid Based Complement Alternat Med. 2014;2014:483294. doi: 10.1155/2014/483294. Epub 2014 Jul 7. | Neuroprotection | Review |
| 26124961 | The current approaches against RP include the Chinese herbal medicine, acupuncture, moxibustion, gene therapy, neuroprotection therapy, neurotrophic growth factors, antiapoptotic agents, ribozyme therapy, RNAi, retinal transplantation, dietary supplementation, retinal prostheses, stem cell therapy, and so on. | J Ophthalmol. 2015;2015:421269. doi: 10.1155/2015/421269. Epub 2015 Jun 1. | Neuroprotection | Review |
| 26786869 | One systematic review of preclinical study indicates that acupuncture decreases infarct volume, ameliorates neurological impairment and plays a neuroprotective role in animal models with acute ischemia. | Sci Rep. 2016 Jan 20;6:19521. doi: 10.1038/srep19521. | Neuroprotection | Review |
| 29143805 | Acupuncture improves the division of stem cells by enhancing GSK-3β/PP2A expression, increasing neurotrophic factors BDNF/VEGF (brain-derived neurotrophic factor/vascular endothelial growth factor), and upregulating neuroprotective substances such as retinoic acid. | Int J Mol Sci. 2017 Oct 28;18(11):2270. doi: 10.3390/ijms18112270. | Neuroprotection | Review |
| 29234418 | In addition to AD, studies have reported the utility of acupuncture treatment in Parkinson's disease, showing that it improves symptoms and has a neuroprotective role. | Evid Based Complement Alternat Med. 2017;2017:6512520. doi: 10.1155/2017/6512520. Epub 2017 Sep 27. | Neuroprotection | Review |
| 29234418 | Acupuncture may have a potential neuroprotective role worth studying regarding the treatment of neurological diseases. | Evid Based Complement Alternat Med. 2017;2017:6512520. doi: 10.1155/2017/6512520. Epub 2017 Sep 27. | Neuroprotection | Review |
| 29722298 | Electroacupuncture pretreatment or treatment after ischemic stroke by using appropriate electroacupuncture parameters generates neuroprotective and neuroregenerative effects that increase cerebral blood flow, regulate oxidative stress, attenuate glutamate excitotoxicity, maintain blood-brain barrier integrity, inhibit apoptosis, increase growth factor production, and induce cerebral ischemic tolerance. | Neural Regen Res. 2018 Apr;13(4):573-583. doi: 10.4103/1673-5374.230272. | Neuroprotection Toxic Side Effects Blood Flow | Review |
| 29722298 | A large number of animal experiments revealed the neuroprotective effects of acupuncture on ischemic stroke (Feng and Zhang, 2014). | Neural Regen Res. 2018 Apr;13(4):573-583. doi: 10.4103/1673-5374.230272. | Neuroprotection | Review |
| 29722298 | Acupuncture and EA can exert similar neuroprotective actions in a MCAo rat model (Xu et al., 2014). | Neural Regen Res. 2018 Apr;13(4):573-583. doi: 10.4103/1673-5374.230272. | Neuroprotection | Review |
| 29722303 | Thus, stimulation of this acupuncture point appears to replicate many of the neuroprotective features of migraine without the pain of a full attack. | Neural Regen Res. 2018 Apr;13(4):609-615. doi: 10.4103/1673-5374.230275. | Neuroprotection | Review |
| 30050856 | Electroacupuncture has been shown to have neuroprotective effects in nonhuman primate models of cerebral ischemia and stroke. | Vet Med (Auckl). 2017 Aug 24;8:53-58. doi: 10.2147/VMRR.S125609. eCollection 2017. | Neuroprotection | Review |
| 30298094 | Interestingly, a significant difference in ADC and FA values between the two groups was observed, with a higher FA value in the acupuncture group than the control group, thus suggesting the effectiveness of acupuncture for protecting neurons by postponing Wallerian degeneration of brain infarction, and facilitating recovery. | Evid Based Complement Alternat Med. 2018 Sep 12;2018:8107508. doi: 10.1155/2018/8107508. eCollection 2018. | Neuroprotection | Review |
| 30424749 | The included studies investigated several signaling pathways to gain a better understanding of the mechanism of improving cognitive function via acupuncture, including modulating the production and degradation of free radicals to reduce brain damage, exerting anti-apoptotic effects by up-regulating B-cell lymphoma-2 (Bcl-2) and counter-regulating Bcl-2-associated X protein (Bax) to protect neurons, enhancing glucose metabolism in the brain, reducing tumor protein P53 and Noxa expression to protect pyramidal cells from apoptosis, increasing cerebral blood flow for increased glucose and oxygen supply to neurons, exerting neuroprotective effects via an antioxidative pathway mediated by nuclear factor erythroid2-related factor 2 (Nrf2), and increasing complex enzymes to protect neurons from oxidative stress. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Neuroprotection Cognitive Function Blood Flow | Review |
| 30424749 | The present study indicated that acupuncture protects neurons during vascular dementia mainly through enhancing oxygen and glucose metabolism and anti-apoptosis and antioxidant properties. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Neuroprotection | Review |
| 30424749 | Furthermore, our findings indicates that acupuncture could protect neurons in animal models of vascular dementia through enhanced oxygen and glucose metabolism, as well as antioxidant and anti-apoptosis effects. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Neuroprotection | Review |
| 30618558 | Mechanisms Involved in the Neuroprotection of Electroacupuncture Therapy for Ischemic Stroke | Front Neurosci. 2018 Dec 11;12:929. doi: 10.3389/fnins.2018.00929. eCollection 2018. | Neuroprotection | Review |
| 30855351 | Finally, recent researches showed that the endocannabinoid system has been involved in many of the various therapeutic effects induced by acupuncture, the biological effects including analgesia, neuroprotection and cardiovascular regulation shared by both acupuncture and the endocannabinoid system. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Neuroprotection Cardiovascular | Review |
| 31139074 | Objective: To evaluate the neuroprotective effect of acupuncture in animal models of PD. | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | In contrast, it was also reported that acupuncture treatment did not demonstrate a neuroprotective effect in an MPTP mouse model (Yang et al.,). | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | Therefore, the present systematic review and meta-analysis aimed to assess the pre-clinical evidence supporting the neuroprotective effects of acupuncture in rodent models of PD. | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | English-language studies that examined the neuroprotective effect of acupuncture in PD rodent models were included in the present study. | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | Effect of Acupuncture on DA Neuron Protection | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | First, the neurotrophic factor-induced cell proliferation pathway was suggested as a potential mechanism to explain the neuroprotective effect of acupuncture. | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | Additionally, it was found that acupuncture activates hypothalamic melanin-concentrating hormone (MCH), which is involved in neuronal protection by upregulating a downstream pathway related to neuroprotection in the SN of MPTP-induced and A53T α-syn mutant PD mice (Park et al.,). | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | Although all of these processes need to be clinically verified, the scientific evidence revealed strong possibilities of a neuroprotective effect of acupuncture on PD. | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | In contrast, we found that one study reported non-meaningful changes in TH+ levels (Jia et al.,) and contradicting results in another study (Yang et al.,), which reported that acupuncture is not effective in improving DA neuron protection. | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | Instead, studies have suggested that acupuncture treatment has another effect on PD animals, which is improvement of synaptic function in addition to neuronal protection (Jia et al.,; Kim et al.,; Yang et al.,; Sun et al.,; Rui et al.,; Yu et al.,). | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31139074 | Nevertheless, it is meaningful that the potential neuroprotective effect of acupuncture treatment was evident in most of the included studies. | Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Acupuncture affects synaptic plasticity, causes an increase in neurotrophic factors, and results in neuroprotection, cell proliferation, antiapoptosis, antioxidant activity, anti-inflammation, and maintenance of the blood-brain barrier. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Acupuncture was reported to exert a neuroprotective effect on dopaminergic neurons through anti-inflammatory and neurotrophic effects. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Acupuncture causes an increase in the expression of neurotrophic factors, such as BDNF and glial-derived neurotrophic factor (GDNF), in the central nervous system (CNS), exerts a neuroprotective effect on hypoxic-ischemic insults, and results in neurogenesis after the reconstruction phase. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Therefore, acupuncture results in cell proliferation, antiapoptosis, neuroprotection, and BBB maintenance. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | At the level of molecular signal transduction, acupuncture exerts a neuroprotective effect by increasing the angiopoietin level and reducing TNF-α and NF-κB levels. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Furthermore, acupuncture augments the antiapoptosis process and provides neuroprotection by increasing the GRP78 level and reducing the CHOP level. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | reported that acupuncture on HT8 elevated the serum corticosterone level and hippocampal mTOR phosphorylation, Akt, ERK, p70S6K, p4E-BP1, and CREB enhanced the effect of BDNF on neuroprotection and synaptic plasticity. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Acupuncture on GV20 reduces Aβ deposits in the brain, elevates the BDNF level, and exerts a neuroprotective effect on CNS cells. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Acupuncture has been reported to exert neuroprotective effects that increase the levels of endogenous neurotrophins and modulate the apoptosis and neuroinflammation of dopaminergic neurons in the SN. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31379957 | Through the aforementioned pathways, acupuncture affects synaptic plasticity, elevates neurotrophic factors, and results in neuroprotection, cell proliferation, antiapoptosis, antioxidant activity, anti-inflammation, and maintenance of the BBB. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Neuroprotection | Review |
| 31467579 | Deng G and Jiang S have revealed the role of electroacupuncture in neuroprotection and neuropathic pain in specific acupoints, and studies by Deng G et al. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Neuroprotection Neuropathic Pain | Review |
| 32148660 | Acupuncture provides neuroprotection through various mechanisms. | Oxid Med Cell Longev. 2020 Feb 13;2020:9641904. doi: 10.1155/2020/9641904. eCollection 2020. | Neuroprotection | Review |
| 32218746 | The effect of PbP per se has been studied in parents and their children for temper tantrums, acupuncture for postoperative symptoms, as well as for neuroprotection in very preterm-born infants. | Front Psychiatry. 2020 Mar 11;11:169. doi: 10.3389/fpsyt.2020.00169. eCollection 2020. | Neuroprotection | Review |
| 32337259 | Several signaling pathways associated with the neuroprotective mechanisms of acupuncture were extensively investigated in those studies, including correction of the abnormal cerebral glycolysis metabolism, enhancement of synaptic plasticity, antiapoptosis and repair of neuronal cells, degradation and decreases of Aβ protein deposits, upregulation of the hippocampal expression of BDNF and TrkB, and reduction of neuron loss and apoptosis. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Neuroprotection | Review |
| 32337259 | The findings suggest that acupuncture may have a neuroprotective effect in animal models of AD, and this benefit is more than just a placebo effect. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Neuroprotection | Review |
| 32337259 | and Cao et al., acupuncture could alleviate cognitive impairments by modulating multiple signaling pathways involved in neuroprotection and neurorepair. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Neuroprotection | Review |
| 32337259 | Furthermore, our findings implies that the neuroprotective effects of acupuncture might be achieved through blocking the apoptosis and loss of neuronal cells, correcting of the abnormal cerebral glycolysis metabolism, enhancing of synaptic plasticity, degrading and decreasing of Aβ deposits, and upregulating of the hippocampal expression of BDNF. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Neuroprotection | Review |
| 33029119 | Acupuncture may exert neuroprotective effects in several nervous system diseases through the modulation of BDNF. | Neural Plast. 2020 Sep 22;2020:8850653. doi: 10.1155/2020/8850653. eCollection 2020. | Neuroprotection | Review |
| 33178387 | Acupuncture therapy possesses the potential in alleviating oxidative stress caused by cerebral ischemia, which may be linked with the neuroprotective effect of acupuncture. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Neuroprotection | Review |
| 33178387 | Recently, emerging experimental studies have demonstrated that acupuncture exerts the neuroprotective role in acute stroke via its antioxidant potential. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Neuroprotection | Review |
| 33178387 | investigated whether NOX was involved in the neuroprotection of acupuncture in a rat BCCAO model. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Neuroprotection | Review |
| 33178387 | Nowadays, various basic studies have also confirmed that scalp acupuncture at Baihui plays multiple neuroprotective roles including antiapoptosis, anti-inflammatory, and perfusion augmentation in the pathophysiological process of laboratory models of ischemic stroke, not only regulating oxidative stress. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Neuroprotection | Review |
| 33178387 | Hence, acupuncture stands a chance of serving as one of the potential complementary approaches for neuroprotection against acute stroke, especially in the early stage. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Neuroprotection | Review |
| 33178387 | Acupuncture therapy possesses the potential in alleviating oxidative stress caused by cerebral ischemia, which may be linked with the neuroprotective effect of acupuncture. | Oxid Med Cell Longev. 2020 Oct 24;2020:7875396. doi: 10.1155/2020/7875396. eCollection 2020. | Neuroprotection | Review |
| 33229734 | (2015a) found that acupuncture up-regulates the nuclear translocation of nuclear factor erythroid2-related factor 2 (Nrf2) in neurons as well as the expression of Nrf2 and the downstream target genes NADPH quinone oxidoreductase-1 and heme oxygenase-1 in hippocampal neurons, reduces Nrf2-dependent activation of microglia, improves cognitive impairment caused by bilateral carotid ischemia, and exerts neuroprotective effects. | Neural Regen Res. 2021 May;16(5):944-954. doi: 10.4103/1673-5374.297061. | Neuroprotection | Review |
| 33229734 | These studies confirmed that acupuncture exerts neuroprotective effects through the biphasic action of astrocytes, reduces secondary inflammatory damage, and promotes nerve function restoration. | Neural Regen Res. 2021 May;16(5):944-954. doi: 10.4103/1673-5374.297061. | Neuroprotection | Review |
| 33408601 | Fewer studies have examined effects on the pathological process resulting from β-amyloid accumulation and deposition, which could be a more convincing mechanism for explaining acupuncture-induced neuroprotection. | Front Neurosci. 2020 Dec 21;14:549772. doi: 10.3389/fnins.2020.549772. eCollection 2020. | Neuroprotection | Review |
| 33883931 | In addition, the neuroprotective effects of acupuncture have been demonstrated in many neurological disorders, involving its regulation of signaling pathways of endogenous biological mediators, especially the protein family of neurotrophic factors. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Neuroprotection | Review |
| 33883931 | Although there is no direct evidence supporting the neuroprotective action of acupuncture in PIPN, the regulation of neurotrophic factors might be one of the possible neuroprotective mechanisms potentiating the therapeutic effect of acupuncture on PIPN, and that requires further investigations in the future. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Neuroprotection | Review |
| 33917977 | The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Neuroprotection Stress Response | Review |
| 33917977 | The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Neuroprotection Stress Response | Review |
| 33917977 | Acupuncture has been reported to promote neuroprotection, neurogenesis, and synaptic plasticity in several areas of the brain in the PTSD model. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Neuroprotection | Review |
| 33917977 | The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Neuroprotection Stress Response | Review |
| 34188677 | Studies that examined the neuroprotective effect of acupuncture in stroke patients were included in the present study. | Neural Plast. 2021 Jun 2;2021:8841720. doi: 10.1155/2021/8841720. eCollection 2021. | Neuroprotection | Review |
| 34307076 | In addition to the positive effects mediated by several neurotransmitters and NTs, there is experimental evidence from a rat spinal cord injury model that acupuncture provides neuroprotection via mitigating inflammation and microglial activation. | Open Vet J. 2021 Apr-Jun;11(2):203-209. doi: 10.5455/OVJ.2021.v11.i2.3. Epub 2021 Apr 15. | Neuroprotection | Review |
| 34992414 | Acupuncture also exerts its anti-inflammatory role to achieve neuroprotection via inhibition of oxidative stress and activation of the endogenous cannabinoid system. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Neuroprotection | Review |
| 34992414 | Acupuncture protects DA neurons by affecting the brain-enteritis state. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Neuroprotection | Review |
| 35168522 | In addition, acupuncture at Shenmen (HT7) also upregulated the expression of BDNF in the PFC, suggesting that acupuncture has neuroprotective effects in depression via up-regulating BDNF (Fig. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Neuroprotection Depression | Review |
| 35233354 | These findings indicate that acupuncture at ST36 has a neuroprotective potential mediated by inhibition of astrogliosis. | Tzu Chi Med J. 2021 Apr 19;34(1):35-43. doi: 10.4103/tcmj.tcmj_275_20. eCollection 2022 Jan-Mar. | Neuroprotection | Review |
| 35241146 | Clinical and laboratory evidence suggests that acupuncture induces multilevel regulation through complex mechanisms against cerebral ischemia, including: (1) neuroprotection, (2) collateral circulation reconstruction, (3) neuro-regeneration, and (4) modulating brain glucose metabolism and brain plasticity. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Neuroprotection Circulation | Review |
| 35241146 | Unlike neuroprotective agents, acupuncture is a multi-target neuroprotective solution, which enhances endogenous neuroprotection functions to diminish brain edema and the volume of cerebral infarction, thus promoting the recovery of neural functions via the following therapeutic mechanisms. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Neuroprotection | Review |
| 35241146 | Acupuncture therapy possesses the potential to reduce oxidative stress caused by cerebral ischemia, which may be related to the neuroprotective effect of acupuncture. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Neuroprotection | Review |
| 35281899 | Scientific researches into the mechanisms of acupuncture have been rapidly growing in the past several decades, which prove that acupuncture can exert anti-inflammatory, analgesic, antiapoptotic, antioxidative, neuroprotective and antidepressant effects. | Front Pharmacol. 2022 Feb 25;13:816025. doi: 10.3389/fphar.2022.816025. eCollection 2022. | Neuroprotection | Review |
| 35449821 | A meta-analysis revealed that acupuncture at DU20 manifested potential neuroprotective effects on stroke. | Evid Based Complement Alternat Med. 2022 Apr 11;2022:7705256. doi: 10.1155/2022/7705256. eCollection 2022. | Neuroprotection | Review |
| 35462893 | Acupuncture-induced neuroprotection includes several mechanisms such as reducing oxidative stress, inhibiting the inflammatory response and neuronal apoptosis, alleviating glial scar formation, promoting neural stem cell differentiation, and improving microcirculation within the injured area. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuroprotection Microcirculation | Review |
| 35462893 | Acupuncture has been demonstrated to have a neuroprotective role in cerebral ischemia by regulating HSP 70. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuroprotection | Review |
| 35462893 | Neuroprotection by acupuncture is partially mediated by inhibiting inflammation and microglial activation after SCI. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Neuroprotection | Review |
| 35968313 | Moreover, acupuncture at ST36 has neuroprotective effects in hydrocephalus infantile rats, exhibiting anti-inflammatory and neuroprotective effects via inhibition of reactive astrogliosis. | Front Neurol. 2022 Jul 22;13:930753. doi: 10.3389/fneur.2022.930753. eCollection 2022. | Neuroprotection | Review |
| 36211826 | Interestingly, laser acupuncture improved cerebral ischemia-induced cognitive deficits and modulated the expression of creb, bdnf, bcl-2, and bax genes, exerting neuroprotective effects. | Oxid Med Cell Longev. 2022 Sep 28;2022:6080282. doi: 10.1155/2022/6080282. eCollection 2022. | Neuroprotection | Review |
| 36340786 | Acupuncture near ST36 can significantly increase the local concentration of extracellular adenosine, a neuromodulator with neuroprotective, anti-inflammatory, and analgesic properties. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Neuroprotection | Review |
| 36439200 | Thus, acupuncture may play a neuroprotective role in ischemic stroke by modulating the expression of BDNF, but the functional verification of this possibility remains to be obtained. | Front Cell Neurosci. 2022 Nov 10;16:817732. doi: 10.3389/fncel.2022.817732. eCollection 2022. | Neuroprotection | Review |
| 36670425 | Acupuncture at the same acupoints restored the 2VO-induced elevation of hippocampus thioredoxin-interacting protein (TXNIP), NLRP3, caspase-1, and IL-1β, indicating that acupuncture may perform neuroprotective effects in VD rats by decreasing TXNIP-related oxidative stress and inflammation. | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Neuroprotection | Review |
| 36741282 | Nape cluster acupuncture has neuroprotective and restorative effects in rats with post-ischemic stroke sequelae, and its mechanism may involve effective upregulation of BDNF and NGF protein expression. | Front Neurol. 2023 Jan 20;14:1082625. doi: 10.3389/fneur.2023.1082625. eCollection 2023. | Neuroprotection | Review |
| 36741282 | EA treatment at Quchi (LI11) and ST36 acupoints exerted neuroprotective effects on I/R-injured rats through the proliferation of GFAP/vimentin/nestin-positive reactive astrocytes and secretion of potentially reactive astrocyte-derived BDNF and may also be related to the activation of cortical PGC-1α/Irisin (FNDC5)/BDNF pathway by electroacupuncture. | Front Neurol. 2023 Jan 20;14:1082625. doi: 10.3389/fneur.2023.1082625. eCollection 2023. | Neuroprotection | Review |
| 37025378 | Researchers speculated that electroacupuncture acted as a neuroprotective role on dopaminergic neurons by inhibiting inflammation in the SN to alleviate behavioral defects in mice, and this effect may be related to the regulation of intestinal microbes. | Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. | Neuroprotection | Review |
| 37025378 | Neuroprotection occurs through manual acupuncture by blocking neuroinflammation responses and apoptosis, and increasing the level of dopaminergic fibers and neurons in the striatum and SN. | Front Neurosci. 2023 Mar 21;17:1146946. doi: 10.3389/fnins.2023.1146946. eCollection 2023. | Neuroprotection | Review |
| 37091130 | In summary, it can be reasonably speculated that acupuncture may be a pathway that regulates the expression and activity of glutamate and its receptors and reduces excitotoxicity to interfere with cell death in the penumbra region to improve the survival rate of penumbra cells and protect neurons. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Neuroprotection Toxic Side Effects | Review |
| 37091130 | Acupuncture can be neuroprotective by inhibiting the excitotoxic effects of glutamate by activating the expression activity of GABA. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Neuroprotection Toxic Side Effects | Review |
| 37200784 | High-frequency electroacupuncture has a better neuroprotective effect, as it can lower malondialdehyde levels and boost superoxide dismutase activity, reducing free radical damage, protecting nerve cells, and repairing damaged tissues (Shi et al.,). | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Neuroprotection | Review |
| 37200784 | In a study, acupuncture was shown to increase the expression of amygdala BDNF and weaken TH in PTSD model animals, implying that acupuncture promotes neuroprotection and inhibits the active amygdala, which influences PTSD prevention and treatment (Zhu and Lu,). | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Neuroprotection | Review |
| 37200784 | Acupuncture was reported to counteract the neurotoxicity of excitatory amino acids, reduce stress-induced nerve cell damage, and promote neuroprotective effects and fear memory regression by upregulating BDNF in the PFC (Chen et al.,) and downregulating mPFC GABAARal (Zhu et al.,). | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Neuroprotection Toxic Side Effects | Review |
| 37200784 | Moreover, acupuncture's effect on PTSD may be mediated by the promotion of neuroprotection, neurogenesis, and synaptic plasticity in multiple brain areas, the regulation of stress responses in the neuroendocrine system, and signaling pathway involvement. | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Neuroprotection Stress Response | Review |
| 37229426 | Animal experiments have proved that there is a certain scientific basis for acupuncture to improve motor function in PD, such as reducing neuronal apoptosis of the striatum (Lu et al.,), normalizing the brain functional connectivity (Oh et al.,), inhibiting the level of lipid peroxides in dopaminergic neurons and protect neurons from oxidative damage (Zuo et al.,). | Front Neurosci. 2023 May 9;17:1125626. doi: 10.3389/fnins.2023.1125626. eCollection 2023. | Neuroprotection Motor Function | Review |
| 37289799 | Although the underlying therapeutic mechanism by which scalp electro-acupuncture promotes beneficial effects against various neuropsychiatric disorders needs to be further elucidated, this approach has the potential for neuroprotective effects and modulating the functional connectivity between brain regions. | PLoS One. 2023 Jun 8;18(6):e0286671. doi: 10.1371/journal.pone.0286671. eCollection 2023. | Neuroprotection | Review |
| 37505150 | Studies have found that early electroacupuncture intervention delayed the time of rotenone-induced dyskinesia in PD mice, reduced the loss of dopaminergic neurons in the SN, and played a good neuroprotective role in the degenerative changes of PD, which may be related to the improvement of intestinal inflammatory response by acupuncture, inhibition of microglial activation, and reduction of neuroinflammatory response. | Medicine (Baltimore). 2023 Jul 28;102(30):e34278. doi: 10.1097/MD.0000000000034278. | Neuroprotection | Review |
| 37510483 | Acupuncture is therapeutically effective for motor symptoms and provides neuroprotection by preventing the death of dopaminergic neurons. | Healthcare (Basel). 2023 Jul 17;11(14):2042. doi: 10.3390/healthcare11142042. | Neuroprotection | Review |
| 37614343 | Previous studies have presented the neuroprotective activity and neurotransmitter regulation of acupuncture therapy. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Neuroprotection | Review |
| 37614343 | Acupuncture therapy, which has beneficial effects on neuroprotection, has been shown to improve serum and hippocampal 5-HT and DA levels in depression model rats. | Front Neurosci. 2023 Aug 8;17:1243029. doi: 10.3389/fnins.2023.1243029. eCollection 2023. | Neuroprotection Depression | Review |
| 37795371 | Another rat model shows that acupuncture, treatment of acupoints GB34, LR3, ST36 and SP10, exerts an antioxidant action and showed neuroprotective properties. | Front Endocrinol (Lausanne). 2023 Sep 18;14:1236370. doi: 10.3389/fendo.2023.1236370. eCollection 2023. | Neuroprotection | Review |
| 38013378 | Acupuncture, particularly electroacupuncture, can enhance the neuroprotective effect, and the combination of the 2 can more effectively promote recovery in patients with dysfunction. | Medicine (Baltimore). 2023 Nov 24;102(47):e36160. doi: 10.1097/MD.0000000000036160. | Neuroprotection | Review |
| 22380768 | BACKGROUND: Acupuncture pretreatment exerts neuroprotective and cardioprotective effects in animal models and in adult patients underwent cardiac surgery; however, data in pediatric patient are unavailable. | Paediatr Anaesth. 2012 Aug;22(8):805-11. doi: 10.1111/j.1460-9592.2012.03822.x. Epub 2012 Mar 2. | Neuroprotection | Clinic |
| 15955428 | In the light of these findings, it is suggested that EA on specific and established acupoints that are commonly used in clinical management of cerebral ischemia may have elicited an up-regulated expression of GABA that would have a neuroprotective effect. | Neurosci Lett. 2005 Aug 5;383(3):317-21. doi: 10.1016/j.neulet.2005.04.032. | Neuroprotection | Mechanism |
| 14725963 | This study aimed to clarify the neuroprotective mechanism of electro-acupuncture (EA) preconditioning on hypoxic-ischemic brain injury (HIBI). | Brain Res. 2004 Feb 13;998(1):13-9. doi: 10.1016/j.brainres.2003.10.043. | Neuroprotection | Mechanism |
| 26116163 | CONCLUSIONS: All of these results suggest that acupuncture as a potential treatment may exert neuroprotective effects via inhibiting cellular apoptosis, increased GDNF and BDNF expression levels in rat hippocampus experiencing HI. | J Ethnopharmacol. 2015 Aug 22;172:124-32. doi: 10.1016/j.jep.2015.06.032. Epub 2015 Jun 23. | Neuroprotection | Mechanism |
| 20308770 | Potential neuroprotective effects of acupuncture stimulation on diabetes mellitus in a global ischemic rat model. | Physiol Meas. 2010 May;31(5):633-47. doi: 10.1088/0967-3334/31/5/003. Epub 2010 Mar 22. | Neuroprotection | Mechanism |
| 20034450 | OBJECTIVES: To find new biomarkers by stimulating acupuncture point GB34 (Yangneungcheon) which has neuroprotective effect on the mouse model of Parkinson's disease, analysis of cDNA microarray on mRNAs of the substantia nigra was performed. | Neurol Res. 2010 Feb;32 Suppl 1:74-8. doi: 10.1179/016164109X12537002794165. | Neuroprotection | Mechanism |
| 20034450 | These biomarkers might provide a promising clue for understanding the neuroprotective effect of acupuncture in Parkinson's disease. | Neurol Res. 2010 Feb;32 Suppl 1:74-8. doi: 10.1179/016164109X12537002794165. | Neuroprotection | Mechanism |
| 18401708 | This EA-mediated neuroprotection is associated with a decrease in the number of Bax immunoreactive neurons and an increase in the number of Bcl-2 immunoreactive neurons. | Neurochem Res. 2008 Nov;33(11):2214-21. doi: 10.1007/s11064-008-9677-x. Epub 2008 Apr 10. | Immunity Neuroprotection | Mechanism |
| 25002029 | Neuroprotection of up-regulated carbon monoxide by electrical acupuncture on perinatal hypoxic-ischemic brain damage in rats. | Neurochem Res. 2014 Sep;39(9):1724-32. doi: 10.1007/s11064-014-1366-3. Epub 2014 Jul 8. | Neuroprotection | Mechanism |
| 25002029 | This study investigated the neuroprotection and potential mechanism of carbon monoxide (CO) against perinatal hypoxic-ischemic brain damage in rats by electrical acupuncture (EA). | Neurochem Res. 2014 Sep;39(9):1724-32. doi: 10.1007/s11064-014-1366-3. Epub 2014 Jul 8. | Neuroprotection | Mechanism |
| 27664868 | Accumulating evidence demonstrates that acupuncture and electroacupuncture (EA) can exert a neuroprotective role for cerebral ischemia, but their precise mechanism remains largely unknown. | Neurosci Lett. 2016 Oct 28;633:158-164. doi: 10.1016/j.neulet.2016.09.033. Epub 2016 Sep 21. | Neuroprotection | Mechanism |
| 27664868 | Therefore, in this study, the effects of EA stimulation on cerebral ischemia reperfusion and its neuroprotective mechanisms were investigated. | Neurosci Lett. 2016 Oct 28;633:158-164. doi: 10.1016/j.neulet.2016.09.033. Epub 2016 Sep 21. | Neuroprotection | Mechanism |
| 27664868 | These findings indicate that EA stimulation at Baihui and Siguan acupoints exerts a neuroprotective role against cerebral ischemia-reperfusion injury, which is probably associated with the inhibition of apoptosis and altering the balance of MMP-9/TIMP-1 expression. | Neurosci Lett. 2016 Oct 28;633:158-164. doi: 10.1016/j.neulet.2016.09.033. Epub 2016 Sep 21. | Neuroprotection | Mechanism |
| 17173870 | Using a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD), this study investigated on the neuroprotective effects of acupuncture by examining whether acupuncture contributed to inhibiting microglial activation and inflammatory events. | Brain Res. 2007 Feb 2;1131(1):211-9. doi: 10.1016/j.brainres.2006.10.089. Epub 2006 Dec 14. | Neuroprotection | Mechanism |
| 17173870 | These experiments demonstrated that acupuncture inhibited the decreased of the tyrosine hydroxylase (TH) immunoreactivity (IR) and generated a neuroprotective effects in the striatum (ST) and the substantia nigra (SN) on days 1, 3, and 7 post-MPTP injections. | Brain Res. 2007 Feb 2;1131(1):211-9. doi: 10.1016/j.brainres.2006.10.089. Epub 2006 Dec 14. | Immunity Neuroprotection | Mechanism |
| 17173870 | On the basis of these results, we suggest that acupuncture could be used as a neuroprotective intervention for the purpose of inhibiting microglial activation and inflammatory events in PD. | Brain Res. 2007 Feb 2;1131(1):211-9. doi: 10.1016/j.brainres.2006.10.089. Epub 2006 Dec 14. | Neuroprotection | Mechanism |
| 24055977 | OBJECTIVE: Electroacupuncture (EA) has been widely used for treatment of stroke, but there is little information on the effect of EA on the neuroprotective function in traumatic brain injury (TBI). | Acupunct Med. 2013 Dec;31(4):395-403. doi: 10.1136/acupmed-2013-010406. Epub 2013 Sep 20. | Neuroprotection | Mechanism |
| 11210429 | The results give us some hints for the neuroprotective mechanism of EA, that is, EA may partially exert protective effects on neurons through regulating the blood dynamics and the endogenous expression of bFGF. | Neurol Res. 2001 Jan;23(1):47-50. doi: 10.1179/016164101101198271. | Neuroprotection | Mechanism |
| 31857129 | Mechanism of the neuroprotective effect of injecting brain cells on ST36 in an animal model of Parkinson's disease. | Neurosci Lett. 2020 Jan 19;717:134698. doi: 10.1016/j.neulet.2019.134698. Epub 2019 Dec 16. | Neuroprotection | Mechanism |
| 31857129 | Taken together, these results suggest that the injection of choroid plexus cell at ST36 had neuroprotective effects in the Parkinson's disease mouse model. | Neurosci Lett. 2020 Jan 19;717:134698. doi: 10.1016/j.neulet.2019.134698. Epub 2019 Dec 16. | Neuroprotection | Mechanism |
| 17963318 | The AS also reduced brain atrophy after cerebral infarct, suggesting that AS at the Baihui acupoint acts as neuroprotector. | Am J Chin Med. 2007;35(5):779-91. doi: 10.1142/S0192415X07005260. | Neuroprotection | Mechanism |
| 12668152 | In the present study, we investigated the neuroprotective effects of acupuncture on the nigrostriatal system in rat unilaterally lesioned with 6-hydroxydopamine (6-OHDA, 4 microg/microl, intrastriatal injection) using tyrosine hydroxylase (TH) and receptor for brain-derived neurotrophic factor, trkB, immunohistochemistries. | Exp Neurol. 2003 Mar;180(1):93-8. doi: 10.1016/s0014-4886(02)00031-6. | Immunity Neuroprotection | Mechanism |
| 12668152 | In conclusion, we observed that only acupuncturing without the use of any drug has the neuroprotective effects against neuronal death in the rat PD model and these protective properties of acupuncture could be mediated by trkB. | Exp Neurol. 2003 Mar;180(1):93-8. doi: 10.1016/s0014-4886(02)00031-6. | Neuroprotection | Mechanism |
| 24610411 | These results provide clues to acupuncture's neuroprotective properties. | Chin J Integr Med. 2014 May;20(5):369-74. doi: 10.1007/s11655-014-1800-z. Epub 2014 Mar 7. | Neuroprotection | Mechanism |
| 22842715 | Electroacupuncture at the Quchi and Zusanli acupoints exerts neuroprotective role in cerebral ischemia-reperfusion injured rats via activation of the PI3K/Akt pathway. | Int J Mol Med. 2012 Oct;30(4):791-6. doi: 10.3892/ijmm.2012.1074. Epub 2012 Jul 24. | Neuroprotection | Mechanism |
| 22842715 | However, the precise mechanism of its neuroprotective activities remains largely unknown. | Int J Mol Med. 2012 Oct;30(4):791-6. doi: 10.3892/ijmm.2012.1074. Epub 2012 Jul 24. | Neuroprotection | Mechanism |
| 22842715 | Our data suggest that electroacupuncture at Quchi and Zusanli acupoints exerts neuroprotective function in ischemic stroke via activation of the PI3K/Akt pathway. | Int J Mol Med. 2012 Oct;30(4):791-6. doi: 10.3892/ijmm.2012.1074. Epub 2012 Jul 24. | Neuroprotection | Mechanism |
| 20034453 | Neuroprotective effects of bee venom pharmaceutical acupuncture in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. | Neurol Res. 2010 Feb;32 Suppl 1:88-91. doi: 10.1179/016164109X12537002794282. | Neuroprotection | Mechanism |
| 20034453 | OBJECTIVES: We explored the neuroprotective effects of bee venom acupuncture in acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. | Neurol Res. 2010 Feb;32 Suppl 1:88-91. doi: 10.1179/016164109X12537002794282. | Neuroprotection | Mechanism |
| 21107677 | Neuroprotective changes of striatal degeneration-related gene expression by acupuncture in an MPTP mouse model of Parkinsonism: microarray analysis. | Cell Mol Neurobiol. 2011 Apr;31(3):377-91. doi: 10.1007/s10571-010-9629-2. Epub 2010 Nov 25. | Neuroprotection | Mechanism |
| 23165960 | However, the precise mechanism of its neuroprotective effect remains poorly understood. | Int J Mol Med. 2013 Jan;31(1):75-80. doi: 10.3892/ijmm.2012.1184. Epub 2012 Nov 16. | Neuroprotection | Mechanism |
| 23165960 | Using a focal cerebral I/R injured rat model, in the present study we evaluated the neuroprotective and anti-inflammatory activities of electroacupuncture at Quchi and Zusanli, and investigated the underlying molecular mechanisms. | Int J Mol Med. 2013 Jan;31(1):75-80. doi: 10.3892/ijmm.2012.1184. Epub 2012 Nov 16. | Neuroprotection | Mechanism |
| 23165960 | Our data suggest that electroacupuncture exerts a neuroprotective function in ischemic stroke through inhibition of TLR4/NF-kappaB-mediated inflammation. | Int J Mol Med. 2013 Jan;31(1):75-80. doi: 10.3892/ijmm.2012.1184. Epub 2012 Nov 16. | Neuroprotection | Mechanism |
| 25671811 | CONCLUSION: EA can up-regulate the expression of GLT-1 and inhibit the excessive release of Glu in the striatum in the process of subsequent ischaemic-reperfusion brain injury, which may be one of the mechanisms of inducing BIT and, thus, be neuroprotective for early ischaemic brain injury. | Brain Inj. 2015;29(3):396-402. doi: 10.3109/02699052.2014.896944. | Neuroprotection | Mechanism |
| 25827815 | p53 signalling mediates acupuncture-induced neuroprotection in Parkinson's disease. | Biochem Biophys Res Commun. 2015 May 8;460(3):772-9. doi: 10.1016/j.bbrc.2015.03.105. Epub 2015 Mar 28. | Neuroprotection | Mechanism |
| 25827815 | However, to date, the molecular mechanisms underlying acupuncture's effect on DA neuronal protection are largely unknown. | Biochem Biophys Res Commun. 2015 May 8;460(3):772-9. doi: 10.1016/j.bbrc.2015.03.105. Epub 2015 Mar 28. | Neuroprotection | Mechanism |
| 21770712 | Phosphatidylinositol 3-kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse model of Parkinson's disease. | Int J Neurosci. 2011 Oct;121(10):562-9. doi: 10.3109/00207454.2011.591515. Epub 2011 Jul 19. | Neuroprotection Motor Function | Mechanism |
| 21770712 | However, the mechanistic pathways underlying, such neuroprotection, are poorly understood. | Int J Neurosci. 2011 Oct;121(10):562-9. doi: 10.3109/00207454.2011.591515. Epub 2011 Jul 19. | Neuroprotection | Mechanism |
| 21770712 | Furthermore, we demonstrated for the first time that the brain-specific blockade of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, by intranasal administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway, significantly blocked acupuncture-induced dopaminergic neuron protection and motor function improvement. | Int J Neurosci. 2011 Oct;121(10):562-9. doi: 10.3109/00207454.2011.591515. Epub 2011 Jul 19. | Neuroprotection Motor Function | Mechanism |
| 18942673 | Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model. | Proteomics. 2008 Nov;8(22):4822-32. doi: 10.1002/pmic.200700955. | Neuroprotection | Mechanism |
| 18942673 | The levels of cyclophilin A (CypA), which is a neuroprotective agent, were unchanged by MPTP treatment but were increased in MPTP-EA mice. | Proteomics. 2008 Nov;8(22):4822-32. doi: 10.1002/pmic.200700955. | Neuroprotection | Mechanism |
| 23068989 | In this study, we first evaluated in vitro the neuroprotective function of CGRP on mechanically injured cerebellar granule neurons (CGNs) of rats. | Neurochem Int. 2012 Dec;61(8):1397-403. doi: 10.1016/j.neuint.2012.10.002. Epub 2012 Oct 13. | Neuroprotection | Mechanism |
| 23068989 | Our results suggest that CGRP may be a specific neuropeptide expressed in GV-EA treatment of spinal cord injuries (SCI), and that CGRP may play a neuroprotective role in survival of neurons injured mechanically. | Neurochem Int. 2012 Dec;61(8):1397-403. doi: 10.1016/j.neuint.2012.10.002. Epub 2012 Oct 13. | Neuroprotection | Mechanism |
| 23235115 | Neuroprotective changes of thalamic degeneration-related gene expression by acupuncture in an MPTP mouse model of parkinsonism: microarray analysis. | Gene. 2013 Feb 25;515(2):329-38. doi: 10.1016/j.gene.2012.12.002. Epub 2012 Dec 9. | Neuroprotection | Mechanism |
| 28546432 | Regulation of the endoplasmic reticulum stress response and neuroprotective effects of acupuncture on brain injury caused by heroin addiction. | Acupunct Med. 2017 Oct;35(5):366-373. doi: 10.1136/acupmed-2016-011220. Epub 2017 May 25. | Neuroprotection Stress Response | Mechanism |
| 28546432 | OBJECTIVES: To evaluate regulation of the endoplasmic reticulum stress (ERS) response by acupuncture and to investigate its neuroprotective effect on brain injury caused by heroin addiction. | Acupunct Med. 2017 Oct;35(5):366-373. doi: 10.1136/acupmed-2016-011220. Epub 2017 May 25. | Neuroprotection | Mechanism |
| 28546432 | CONCLUSION: The acupuncture-regulated ERS response appears to mediate the neuroprotective effect of acupuncture in heroin-addicted rats with brain injury. | Acupunct Med. 2017 Oct;35(5):366-373. doi: 10.1136/acupmed-2016-011220. Epub 2017 May 25. | Neuroprotection | Mechanism |
| 28392262 | One possible mechanism of this neuroprotective effect is that EA has regulatory effect on NMDARs. | Life Sci. 2017 May 15;177:8-14. doi: 10.1016/j.lfs.2017.04.004. Epub 2017 Apr 6. | Neuroprotection | Mechanism |
| 27893607 | Acupuncture treatment, a complementary and alternative medicine, is associated with a suggested neuroprotective effect in previous preclinical studies of Parkinson's disease (PD); however, results from human clinical trials have been mixed or unsuccessful. | Neuroreport. 2017 Jan 1;28(1):50-55. doi: 10.1097/WNR.0000000000000709. | Neuroprotection | Mechanism |
| 27893607 | Recent systematic reviews of translational neuroprotective studies showed that the supposed efficacy is confounded by low methodological quality, particularly by a lack of randomization and concealed allocation. | Neuroreport. 2017 Jan 1;28(1):50-55. doi: 10.1097/WNR.0000000000000709. | Neuroprotection | Mechanism |
| 27893607 | Our results indicate that acupuncture is not neuroprotective against nigrostriatal loss in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of PD. | Neuroreport. 2017 Jan 1;28(1):50-55. doi: 10.1097/WNR.0000000000000709. | Neuroprotection | Mechanism |
| 31893437 | Our findings indicate that the MPTP-mediated increase in alpha-syn, and the acupuncture-mediated inhibition of the increase in alpha-syn, may be responsible for the neuroprotective effects of acupuncture in the SN following damage induced by MPTP. | Adv Exp Med Biol. 2020;1232:401-408. doi: 10.1007/978-3-030-34461-0_51. | Neuroprotection | Mechanism |
| 27085942 | The neuro-protective effect of ENT was associated with reduced Bax protein-positive neurons and increased Bcl-2 protein-positive neurons. | J Ethnopharmacol. 2016 Jul 1;187:28-41. doi: 10.1016/j.jep.2016.04.019. Epub 2016 Apr 13. | Neuroprotection | Mechanism |
| 27085942 | And the neuro-protective effect of ENT during the restoration of SCI may be associated with the suppression of both inflammation and activation of PI3K/Akt and MAPK/ERK signaling pathways, resulting from down-regulation of Bax protein, up-regulation of Bcl-2, and inhibition of the mitochondrial apoptosis pathway. | J Ethnopharmacol. 2016 Jul 1;187:28-41. doi: 10.1016/j.jep.2016.04.019. Epub 2016 Apr 13. | Neuroprotection | Mechanism |
| 26895770 | Electroacupuncture improves memory and protects neurons by regulation of the autophagy pathway in a rat model of Alzheimer's disease. | Acupunct Med. 2016 Dec;34(6):449-456. doi: 10.1136/acupmed-2015-010894. Epub 2016 Feb 19. | Neuroprotection | Mechanism |
| 28077367 | This may be related to the neuroprotective effect of NT-3, which may increase the polarisation of M2 microglia/macrophages. | Acupunct Med. 2017 Jun;35(3):224-230. doi: 10.1136/acupmed-2016-011107. Epub 2017 Jan 11. | Neuroprotection | Mechanism |
| 30889365 | Conclusions: The CB2R in the cannabinoid receptor is mainly involved in the electro-acupuncture-induced neuroprotection. | Int J Neurosci. 2019 Sep;129(9):923-929. doi: 10.1080/00207454.2019.1593980. Epub 2019 Apr 2. | Neuroprotection | Mechanism |
| 25481089 | Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis. | Neurochem Int. 2015 Jan;80:79-86. doi: 10.1016/j.neuint.2014.11.008. Epub 2014 Dec 3. | Neuroprotection | Mechanism |
| 25481089 | The current study was directed to evaluate the neuroprotective effect of bee venom acupuncture therapy (BVA) against rotenone-induced oxidative stress, neuroinflammation, and apoptosis in PD mouse model. | Neurochem Int. 2015 Jan;80:79-86. doi: 10.1016/j.neuint.2014.11.008. Epub 2014 Dec 3. | Neuroprotection | Mechanism |
| 25481089 | Therefore, BVA is a promising neuroprotective therapy for PD. | Neurochem Int. 2015 Jan;80:79-86. doi: 10.1016/j.neuint.2014.11.008. Epub 2014 Dec 3. | Neuroprotection | Mechanism |
| 38126262 | EA treatment at GB20 may exert this neuroprotective effect by regulating the CACNA1B-CaM-CaMKII-CREB axis. | Acupunct Med. 2024 Feb;42(1):23-31. doi: 10.1177/09645284231202805. Epub 2023 Oct 15. | Neuroprotection | Mechanism |
| 32796318 | In our previous studies, we demonstrated that acupuncture restores both mechanical hyperalgesia and comorbid cognitive impairment by modulating synaptic plasticity-related protein expression levels in the HIP of a partial sciatic nerve ligation (PSNL) mouse model and exhibits neuroprotective effects in a Parkinson disease mouse model induced by mitochondrial dysfunction. | Pain. 2021 Feb 1;162(2):514-530. doi: 10.1097/j.pain.0000000000002031. | Neuroprotection | Mechanism |
| 24828425 | This study evaluated the hypothesis that acupuncture and electroacupuncture can similarly exert neuroprotective actions in a rat model of middle cerebral artery occlusion (MCAO) by modulating MMP2/AQP4/APQ9 expression and inflammatory cell infiltration. | PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. | Neuroprotection | Mechanism |
| 24828425 | Acupuncture and electroacupuncture at GV20 and ST36 both exercised neuroprotective actions in a rat model of MCAO, with no clear differences between groups A and EA. | PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. | Neuroprotection | Mechanism |
| 24828425 | The current study explored the hypothesis that acupuncture alone and electroacupuncture at GV20 and ST36 can similarly confer neuroprotection in a rat model of middle cerebral artery occlusion (MCAO) via attenuation of MMP2/AQP4/AQP9 expression and inflammatory cell infiltration in the ischemic brain. | PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. | Neuroprotection | Mechanism |
| 24828425 | No significant differences in infarct volume were detected between the three treatment groups (A, EA, and ED), confirming the neuroprotective effect of acupuncture and electroacupuncture against CIRI. | PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. | Neuroprotection | Mechanism |
| 24828425 | Thus, acupuncture and electroacupuncture may share the same mechanism of neuroprotective action, with the added stimulation of electroacupuncture conferring a slight therapeutic advantage. | PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. | Neuroprotection | Mechanism |
| 36422883 | Recent investigations have already proved the neuroprotective efficacy of acupuncture in clinical practice in the treatment of neurological diseases, such as traumatic brain injury (TBI). | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | Since growing evidence has suggested that neuronal autophagy was involved in multiple stages of TBI, this study aims to clarify the autophagy mediating mechanism underlying the neuroprotective effect of acupuncture in TBI rats. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | Three experiments were carried out to detect changes in neuronal autophagy and identify the potential molecular mechanism underlying the neuroprotective effect of acupuncture for TBI treatment. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | However, the specific mechanism remains unclear in acupuncture regulating autophagy to provide a neuroprotective effect after TBI. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | These results suggested that neuronal autophagy may mediate the neuroprotective effect of acupuncture on TBI rats. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | Collectively, acupuncture may mediate the autophagy of cerebral cortex neurons through the mTOR/ULK1 pathway, thus exhibiting a neuroprotective effect. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | In this work, we revealed neuronal autophagy contributes to the neuroprotective effects of acupuncture. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | Surprisingly, acupuncture was able to induce or inhibit autophagy at different time points to protect neurons according to the needs of the body. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 36422883 | The neuroprotective effect may be achieved by regulating the mTOR/ULK1 signaling pathway, thus affecting the initiation of autophagy. | CNS Neurosci Ther. 2023 Jan;29(1):458-470. doi: 10.1111/cns.14018. Epub 2022 Nov 24. | Neuroprotection | Mechanism |
| 26016857 | Therefore, the activation of the Nrf2-ARE pathway is of a neuroprotective nature. | J Neuroinflammation. 2015 May 28;12:103. doi: 10.1186/s12974-015-0302-z. | Neuroprotection | Mechanism |
| 21625423 | Our previous work has shown that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons in the substantia nigra pars compacta from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in male C57BL/6 mice, a model of PD. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection Toxic Side Effects | Mechanism |
| 21625423 | Previous studies have suggested that antioxidants could protect DA neurons in the SNpc from MPTP injury, indicating that antioxidant therapy might be a potential therapeutic choice for PD. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection | Mechanism |
| 21625423 | In this study, we hypothesized that the acupuncture stimulation has neuroprotective effect on DA neurons and this effect is stimulation frequency-dependent and is related to the antioxidative effect of acupuncture. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection | Mechanism |
| 21625423 | These results suggest that 100 Hz EA stimulation can protect DA neurons in the SNpc from MPTP injury. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection | Mechanism |
| 21625423 | Enhanced SOD activity may be neuroprotective since transgenic mice with increased SOD activity are resistant to MPTP injury, while mice with decreased SOD activity are more susceptible to MPTP toxicity. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection Toxic Side Effects | Mechanism |
| 21625423 | We think that the mechanism is due to the regulatory effect of EA on other nuclei in the basal ganglia, such as the globus pallidus, but not the neuroprotective effect of EA on the dopaminergic neurons in the nigrostriatal system (Wang HM et al. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection | Mechanism |
| 26792101 | We also note that such a neuroprotective effect was not found in SG. | Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. | Neuroprotection | Mechanism |
| 26792101 | Nerve transmission might be another possible mechanism for the observed neuroprotective effects of acupuncture, as also observed in a recent electro-acupuncture study in treating system inflammation. | Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. | Neuroprotection | Mechanism |
| 26792101 | Previous studies have proven that stimulation at GB34 showed better neuroprotective effects in the PD mouse model than that at houxi (SI3), shenmai (BL62) and zusanli (ST36). | Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. | Neuroprotection | Mechanism |
| 28358020 | It is known that taurine, a ubiquitous sulfur-containing β-amino acid, exhibits neuroprotective effect through stabilizing the cell membrane and modulating cellular calcium homeostasis and antioxidation. | Sci Rep. 2017 Mar 30;7:45580. doi: 10.1038/srep45580. | Neuroprotection | Mechanism |
| 23737982 | The effects of 100 Hz EA on spontaneous locomotor activity in MPTP mice might not relate with the striatal dopamine, but with its neuroprotective and regulatory effects on motor circuits in the brain. | PLoS One. 2013 May 30;8(5):e64403. doi: 10.1371/journal.pone.0064403. Print 2013. | Neuroprotection | Mechanism |
| 23737982 | Acupuncture might exert extensive neuroprotective and regulatory effects on motor circuits in PD brain. | PLoS One. 2013 May 30;8(5):e64403. doi: 10.1371/journal.pone.0064403. Print 2013. | Neuroprotection | Mechanism |
| 22132113 | We found that acupuncture treatment at acupoint GB34 improved motor function with accompanying dopaminergic neuron protection against MPTP but did not restore striatal dopamine depletion. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection Motor Function | Mechanism |
| 22132113 | In both the 6-hydroxydopamine (6-OHDA) lesioned rat and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned mouse, acupuncture has proven to be neuroprotective. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection | Mechanism |
| 22132113 | Since we previously found that acupoint GB34 exerted the highest neuroprotective effect among several candidate acupoints (GB34, SI3, BL62, and ST36) using the same MPTP protocol, GB34 was chosen for the present study. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection | Mechanism |
| 22132113 | Previously, we reported that GB34 exerted the highest neuroprotective effect among several candidate acupoints in a mice Parkinsonian model. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection | Mechanism |
| 22132113 | The behavioural and neuroprotective effects of acupuncture treatment at GB34 in MPTP mice. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection | Mechanism |
| 22132113 | Recently, we reported that acupuncture can restore MPTP-induced impairment of phosphatidylinositol 3-kinase (PI3K)/Akt cell survival pathway, and PI3K/Akt signalling mediates both acupuncture-induced dopaminergic neuron protection and motor function improvement. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection Motor Function | Mechanism |
| 22132113 | Given LY294002, a specific inhibitor of PI3K, concomitantly blocked both acupuncture-induced dopaminergic neuron protection and motor function improvement, there seems to be a strong correlation between acupuncture-induced neuroprotection and motor function improvement. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection Motor Function | Mechanism |
| 22132113 | 2, 3, 4) results raise one possibility that the acupuncture-induced dopaminergic neuronal protection may lead to increase in dopamine efflux from the surviving dopaminergic neurons, which in turn may result in improved motor function without necessitating restoration of the striatal dopamine content. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Neuroprotection Motor Function | Mechanism |
| 19756387 | Recently, we have shown that the activation of δ-opioid receptor (DOR) is neuroprotective from hypoxic/ischemic injury (, Zhang et al, 1999 SfN Abstract), which is also documented by many other investigators. | Cell Mol Life Sci. 2009 Nov;66(21):3505-16. doi: 10.1007/s00018-009-0136-x. | Neuroprotection | Mechanism |
| 19756387 | In the mechanistic exploration, our initial data suggest that the DOR-induced neuroprotection may be attributed to the stabilization of Na+-K+ homeostasis across the membrane under anoxic stress. | Cell Mol Life Sci. 2009 Nov;66(21):3505-16. doi: 10.1007/s00018-009-0136-x. | Neuroprotection | Mechanism |
| 36003380 | It contributed to neuroprotection against chronic unpredictable mild stress by enhancing brain-derived neurotrophic factor expression and improving hippocampal neurogenesis in a rat model of depression. | Front Immunol. 2022 Aug 8;13:955581. doi: 10.3389/fimmu.2022.955581. eCollection 2022. | Neuroprotection Depression | Mechanism |
| 28913350 | found that acupuncture and EA at the Baihui and Zusanli acupoints can not only reduce infarct size in the brain but also improve neurological function through neuronal protection. | Biomed Res Int. 2017;2017:3178014. doi: 10.1155/2017/3178014. Epub 2017 Aug 24. | Neuroprotection | Mechanism |
| 28913350 | Reactive astrocytes play a neuroprotective role after cerebral ischemia, given that astrocytes enhance glutamate transport after ischemia. | Biomed Res Int. 2017;2017:3178014. doi: 10.1155/2017/3178014. Epub 2017 Aug 24. | Neuroprotection | Mechanism |
| 38026466 | In the vascular dementia model, electroacupuncture at BL17 has a neuroprotective effect by reducing p38-induced neuronal apoptosis in the hippocampus. | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Neuroprotection | Mechanism |
| 38026466 | Although often used, it shows some analgesic and neuroprotective effects in several animal models, which are very limited in experimental data of CSR. | J Pain Res. 2023 Nov 20;16:3945-3960. doi: 10.2147/JPR.S419927. eCollection 2023. | Neuroprotection | Mechanism |
| 36816326 | While many studies have explored different mechanisms regulating inflammatory factor expression, data regarding the neuroprotective effects of acupuncture-mediated immunomodulation are currently lacking. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Immunity Neuroprotection | Mechanism |
| 36816326 | Moreover, some research suggests that acupuncture can protect neurons within the brain by increasing the concentrations of cytokines related to neuronal survival, engaging key neuroprotective signaling pathways and other related regulatory mechanisms. | Heliyon. 2023 Jan 31;9(2):e13346. doi: 10.1016/j.heliyon.2023.e13346. eCollection 2023 Feb. | Neuroprotection | Mechanism |
| 34782576 | However, whether the neuroprotective effects of electroacupuncture (EA) treatment in focal ischemic stroke result from effects on neuronal activity or network connectivity beyond the molecular level remains unknown. | Neural Regen Res. 2022 Jun;17(6):1310-1317. doi: 10.4103/1673-5374.327355. | Neuroprotection | Mechanism |
| 25206406 | Electroacupuncture improves or reverses neuronal impairment in ischemic brain tissue, and regulates energy supply and metabolism in the ischemic area, suggesting a neuroprotective effect. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Neuroprotection | Mechanism |
| 25206406 | This phenomenon might explain the way for astrocytes exert a neuroprotective effect. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Neuroprotection | Mechanism |
| 25206406 | This indicated that pretreatment was more effective in maintaining cell shape and created a neuroprotective effect. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Neuroprotection | Mechanism |
| 25206406 | Moreover, the activated astrocytes could lessen the damage caused by the second ischemic event through inducing endogenous neuroprotective effects, which play an important role in brain ischemic tolerance. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Neuroprotection | Mechanism |
| 25206406 | In addition, Ca2+ fluctuation, homeostasis, and vasomotor function adjustment mechanism may also be associated with endogenous neuroprotective effects. | Neural Regen Res. 2013 Apr 25;8(12):1122-31. doi: 10.3969/j.issn.1673-5374.2013.12.007. | Neuroprotection Motor Function | Mechanism |
| 34630618 | These results indicate that abnormal brain metabolism shown by MRS is reversible, and EA may protect neurons and improve cognitive function by regulating the metabolism of NAA, Glx, and Cho in rats with HE. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Neuroprotection Cognitive Function | Mechanism |
| 34630618 | This experiment also shows that EA has a neuroprotective effect and can improve brain injury. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Neuroprotection | Mechanism |
| 36440366 | In short, we found that EA of the Zusanli (ST36) and Neiguan (PC6) acupoints in p-MCAO rats induced neuroprotective and neuroplastic effects by regulating the mTOR signaling pathway. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | Effects such as the promotion of vascular and nerve regeneration, and the release of neuroprotective neurotrophic factors have been reported. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | In previous studies, EA was found to be neuroprotective via activation of the mTOR pathway. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | Therefore, we hypothesized that EA may promote axonal regeneration after ischemic stroke and exert neuroprotective effects by activating the mTOR pathway. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | In this study, we investigated whether electroacupuncture stimulation of the Zusanli (ST36) and Neiguan (PC6) acupoints regulates axonal regeneration in the contralateral cortex and CST after ischemic brain injury through the mTOR signaling pathway, and activates neuroplasticity to achieve neuroprotective effects. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | To test if EA exerts a neuroprotective effect, we performed neurological deficit scores at 1, 3, 7, and 14 days after p-MCAO. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | These findings indicate that EA treatment can improve cerebral ischemic injury and exert neuroprotective effects by attenuating neuronal damage via mTOR. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | These results suggest that EA can exert neuroprotective effects on p-MCAO rats by modulating the mTOR pathway. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | The body activates neuroprotective mechanisms after ischemic stroke, including the promotion of cell proliferation and neurogenesis, regulation of cerebral blood flow and neurochemicals, and the inhibition of cell death in the ischemic area. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection Blood Flow | Mechanism |
| 36440366 | This demonstrates that EA exerts neuroprotective effects by activating the neuroplasticity-associated proteins GAP-43 and SYN. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | Several studies have shown that mTOR plays a key role in neuroprotection activated by EA in cerebral ischemia and the AKT-mTOR-S6 signaling axis has an important functional role in the intrinsic mechanisms of axonal regeneration. | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 36440366 | According to these results, we demonstrated that mTOR is essential for CST axon sprouting and that EA may promote CST axon regeneration through the mTOR pathway to achieve a neuroprotective effect (Figure 10). | Biomed Res Int. 2022 Nov 14;2022:3470685. doi: 10.1155/2022/3470685. eCollection 2022. | Neuroprotection | Mechanism |
| 24803946 | Neuroprotective Effects of Different Modalities of Acupuncture on Traumatic Spinal Cord Injury in Rats | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Neuroprotection | Mechanism |
| 24803946 | Using male rats of spinal cord injury with the New York University (NYU) Impactor, we investigated the response of electroacupuncture (EA), manual acupuncture (MA), and transcutaneous acupoint electrical stimulation (TAES) at Shuigou (DU26) and Fengfu (DU16) acupoints to understand the effects and mechanisms of acupuncture in neuroprotection and neuronal function recovery after SCI. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Neuroprotection | Mechanism |
| 24803946 | Our data confirmed that the role of acupuncture in neuroprotection and dorsal neuronal function recovery after rat SCI, especially, EA stimulating at Shuigou (DU26) and Fengfu (DU16) can greatly promote neuronal function recovery, which may result from antioxidation, anti-inflammation, and antiapoptosis effects of acupuncture. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Neuroprotection | Mechanism |
| 24803946 | Previous studies showed that acupuncture applied at both Shuigou (DU26) and Yanglingquan (GB34) acupoints simultaneously exerted a neuroprotection which would be partly mediated via inhibition of inflammation and microglial activation; furthermore, acupuncture alleviated neuropathic pain induced by SCI. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Neuroprotection Neuropathic Pain | Mechanism |
| 24803946 | also reported that DU26 was identified as a neuroprotective acupoint after SCI. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Neuroprotection | Mechanism |
| 24803946 | Meanwhile, the neuroprotective effects of the above three modalities of treatments might be mediated in part by antioxidation, anti-inflammation, and antiapoptosis effects following injury. | Evid Based Complement Alternat Med. 2014;2014:431580. doi: 10.1155/2014/431580. Epub 2014 Apr 3. | Neuroprotection | Mechanism |
| 30136700 | EA treatment increased the synaptic curvatures, decreased the width of the synaptic cleft, and thickened the postsynaptic density; 50-Hz EA was more neuroprotective than 2-Hz or 30-Hz EA treatment. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Neuroprotection | Mechanism |
| 30136700 | High-frequency EA also exhibited stronger neuroprotective effects than low-frequency EA (Du and Liu, 2015). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Neuroprotection | Mechanism |
| 30136700 | We did find differences between the 2-Hz and 50-Hz EA groups, indicating that 50-Hz EA treatment for 15 days produced better neuroprotective effects than 2-Hz or 30-Hz EA treatment. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Neuroprotection | Mechanism |
| 30136700 | Inhibition of the GSK-3β signaling pathway by lithium in transgenic mice has been shown to produce neuroprotective effects via regulation of APP proteolytic processing and maturation (Rockenstein et al., 2007). | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Neuroprotection | Mechanism |
| 30136700 | This study deepens our understanding of the mechanisms through which EA has neuroprotective effects related to AD and provides scientific experimental evidence for the optimal EA-stimulation frequency for AD in clinical application. | Neural Regen Res. 2018 Oct;13(10):1833-1841. doi: 10.4103/1673-5374.238620. | Neuroprotection | Mechanism |
| 23970931 | This result indicates that acupuncture stimulation at HT8 suppresses KA-induced neuronal cell death in the CA3 of the hippocampus, and the deactivation of astrocytes can account for the neuroprotective effect of the acupuncture stimulation in this study. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Neuroprotection | Mechanism |
| 23970931 | Changes in the level of CRMP-2 protein have been related to neurodegenerative disorders, and upregulation of CRMP-2 contributes to neuroprotective actions in reactive oxygen species (ROS) stress. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Neuroprotection | Mechanism |
| 23970931 | We found that acupuncture stimulation at HT8 restored the CRMP-2 level that was decreased by KA administration, which suggests that the restoration of the CRMP-2 level by the acupuncture stimulation contributed to the neuroprotective effect against KA toxicity. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Neuroprotection Toxic Side Effects | Mechanism |
| 23970931 | In conclusion, this study demonstrates that acupuncture stimulation at HT8 protects against KA-induced neuronal damage in the hippocampus, and that the acupuncture-mediated neuroprotection may be due, in part, to the normalization of the altered expression of VCP and CRMP-2, which are implicated in cell death mechanisms following KA administration. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Neuroprotection | Mechanism |
| 23970931 | Furthermore, we propose that the PURA, PP5 and TCP-1α upregulation by acupuncture stimulation at HT8 may be a significant event in the neuroprotective effect of acupuncture. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Neuroprotection | Mechanism |
| 23970931 | Neuroprotective effect of acupuncture stimulation at acupoint HT8 in hippocampal CA3 region after kainic acid (KA) administration. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Neuroprotection | Mechanism |
| 31836020 | Some papers reported that the neuroprotective effects induced by EA are related to its anti-inflammatory activity. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Neuroprotection | Mechanism |
| 31836020 | EA as one of the complementary alternative medicine (CAM) techniques showed clinically neuroprotective effects in patients with mild cognitive impairment. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Neuroprotection | Mechanism |
| 25206697 | Neurotrophic factors regulate mature neuron function, protect neuronal survival and promote neuronal regeneration. | Neural Regen Res. 2013 Feb 25;8(6):540-9. doi: 10.3969/j.issn.1673-5374.2013.06.007. | Neuroprotection | Mechanism |
| 29853959 | PPP largely contributes to neuronal protection against oxidative injury by reducing NADP to NADPH. | Evid Based Complement Alternat Med. 2018 Apr 26;2018:5712857. doi: 10.1155/2018/5712857. eCollection 2018. | Neuroprotection | Mechanism |
| 32082125 | The results confirmed that WA had a potent neuroprotective effect on brain damage in exhaustive exercise. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Neuroprotection | Mechanism |
| 32082125 | However, microgial cells also have an important role in neuroprotection (Upthegrove et al.,). | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Neuroprotection | Mechanism |
| 32082125 | Therefore, the appropriate concentration of IFN-γ in the Model + WA group might have neuroprotective effect and helps prevent overtraining injury in the central nervous system. | Front Integr Neurosci. 2020 Jan 31;13:78. doi: 10.3389/fnint.2019.00078. eCollection 2019. | Neuroprotection | Mechanism |
| 37128191 | The neuroprotective effect of EA on MPTP-induced neuronal death was evaluated by measuring the number of TH-positive cells in the SN and optical density in the striatum. | J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. | Neuroprotection | Mechanism |
| 37128191 | GB34 is a representative acupoint to demonstrate the neuroprotective effect in PD animal models. | J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. | Neuroprotection | Mechanism |
| 37128191 | Considering that MA at GB34 also affords a neuroprotective effect and alleviates MPTP-induced behavioral impairment, the effect could be attributed to the needle penetration of the skin at GB34. | J Tradit Complement Med. 2023 Jan 11;13(3):263-269. doi: 10.1016/j.jtcme.2023.01.005. eCollection 2023 May. | Neuroprotection | Mechanism |
| 25558226 | PDGF has been shown to play a neuroprotective role in nervous system injury. | Neural Regen Res. 2012 Sep 25;7(27):2131-5. doi: 10.3969/j.issn.1673-5374.2012.27.007. | Neuroprotection | Mechanism |
| 25558226 | This observation most probably resulted from two reasons: early spinal injury induced by partial dorsal root rhizotomy inhibits the function of spared DRG; in addition, PDGF synthesis is spared in DRG, but its expression is reduced when it is transported to the spinal cord where it participates in early spinal injury neuroprotection, in a similar way to brain-derived neurotrophic factor, neurotrophin-3 and glial cell-derived neurotrophic factor. | Neural Regen Res. 2012 Sep 25;7(27):2131-5. doi: 10.3969/j.issn.1673-5374.2012.27.007. | Neuroprotection | Mechanism |
| 25558226 | This occurred in favor of the spinal cord central process of collateral sprouting for compensation of the removal of partial afferent nerve fibers, and in addition to partial PDGF transportation to the spinal cord for early spinal injury neuroprotection. | Neural Regen Res. 2012 Sep 25;7(27):2131-5. doi: 10.3969/j.issn.1673-5374.2012.27.007. | Neuroprotection | Mechanism |
| 33269744 | Additionally, the PI3K/Akt signaling pathway, which has been associated with both apoptosis and autophagy, is essential for neuroprotection and cell-survival (Feng et al., 2013). | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Neuroprotection | Mechanism |
| 33269744 | Previous studies have suggested a neuroprotective role for the PI3K/Akt signaling pathway in cerebral injury, resulting in the decreased number of apoptotic cells and smaller infarct volumes (Mullonkal and Toledo-Pereyra, 2007; Ishrat et al., 2012). | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Neuroprotection | Mechanism |
| 33269744 | Therefore, EA appears to exert a neuroprotective effect via the activation of the PI3K/Akt signaling pathway. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Neuroprotection | Mechanism |
| 33269744 | Recently, numerous studies have confirmed the neuroprotective mechanism of EA (Xie et al., 2013; Kim et al., 2014). | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Neuroprotection | Mechanism |
| 33269744 | In the present study, we only investigated the effects of EA on the brain regions directly affected by the ischemia-reperfusion injury, but did not explored the long-term neuroprotective and cognitive improvement effects of EA which was mediated by the anti-apoptotic and autophagy responses and the activation of the autophagy network system. | Neural Regen Res. 2021 Jun;16(6):1011-1016. doi: 10.4103/1673-5374.300454. | Neuroprotection | Mechanism |
| 37143500 | CB1R and FAAH belong to endocannabinoid system, which interacts with various endogenous ligands and neurotransmitters with neuroprotective, analgesic, and anti-inflammatory properties. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Neuroprotection | Mechanism |
| 28837077 | However, the most appropriate timing for EA intervention and its effect on dopamine neuronal protection remain unclear. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | In the MPP+ studies, EA inhibited apomorphine induced rotational behavior and locomotor activity, and demonstrated neuroprotective effects via the activation of survival pathways of Akt and brain-derived neurotrophic factor (BDNF) in the SN region. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | In one study, acupuncture at GB34 and LR3 decreased in tyrosine hydroxylase immunoreactivity and generated neuroprotective effects in the SN and striatum on days 1, 3, and 7 post-MPTP injection in mice. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Immunity Neuroprotection | Mechanism |
| 28837077 | It remains unclear as to whether electrical stimulation by EA exerts neuroprotective effects against MPP+-induced dopaminergic neuronal death in vivo. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | Immunohistochemistry (IHC) data of tyrosine hydroxylase also indicated that 50 Hz EA stimulation exerted neuroprotection in the dopaminergic neuronal body in the SN (Figure 1D). | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Immunity Neuroprotection | Mechanism |
| 28837077 | These data indicate that pre-treatment with EA at 50 Hz but not 0 Hz exerts motor improvement and neuroprotection in the MPTP mouse model. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | EA Provides Dopaminergic Neuroprotection in MPP+-Lesioned Rats | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | These data suggest that EA stimulation after MPP+-lesioning provides dopaminergic neuroprotection in rats. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | These data suggest that EA provides dopaminergic neuroprotection in the unilateral MPP+-lesion model by enhancing BDNF and Bcl-2 expressions with activation of the Akt survival pathway in rat SN. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | In this report, we used two different PD animal models to evaluate the effects of EA on motor improvement (symptoms) and dopaminergic neuron protection. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | Following MPTP injections, the application of acupuncture to the GB34 acupoint induced neuroprotective effects in the mouse striatum and SN, resulting in significant recovery to normal levels in the context of behavior and molecular signatures. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | Besides effecting changes in signaling pathways, accumulating evidence suggests that the neuroprotective effects of acupuncture also involve endogenous biological mediators, such as the neurotrophin (NT) family of proteins, specifically, BDNF. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection Side Effects | Mechanism |
| 28837077 | Scientific investigations have shown that stimulation at these acupoints can enhance neuroprotection and improve mobility in PD. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | EA stimulation at 50 Hz but not 0 Hz significantly increased the latency to fall in the rotarod test on day 9; (C) Dopamine content from both sides of the mouse brain showed that EA 50 Hz but not 0 Hz stimulation increased the striatal dopamine content as compared to MPTP-alone treated animals; (D) Immunohistochemistry (IHC) analysis of tyrosine hydroxylase levels in the SN also indicated that 50 Hz EA stimulation exerted neuroprotection in dopaminergic neuronal bodies. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Immunity Neuroprotection | Mechanism |
| 28837077 | EA produces dopaminergic neuroprotection in rats unilaterally lesioned with MPP+. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 28837077 | The data suggest that the way in which EA exerts dopaminergic neuroprotection in the unilateral MPP+-lesion model is by activating Akt phosphorylation and enhancing BDNF and Bcl-2 expression in the rat SN. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection | Mechanism |
| 30127121 | Therefore, we speculated that activated Shh pathway contributes to the neuroprotective effect of Baihui-penetrating-Qubin acupuncture. | Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. | Neuroprotection | Mechanism |
| 25983633 | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | Acupuncture stimulation at the same acupoints also attenuates the decrease in tyrosine hydroxylase (TH) immunoreactivity (IR) and generates neuroprotective effects in the SN in an MPTP-induced mouse model of Parkinsonism. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Immunity Neuroprotection | Mechanism |
| 25983633 | The mechanisms underlying the neuroprotective effects of acupuncture on the SN are thought to be in part related to decreased microglial activation and reduced inflammatory responses; these, in turn, inhibit ferric iron and ferritin heavy chain deposition. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | Because PD is a chronic neurodegenerative disorder, changes in gene expression in the SN in a chronic Parkinsonism animal model should be investigated to identify the neuroprotective mechanisms underlying acupuncture treatment. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | However, acupuncture stimulation at GB34 and LR3 maintained Cdh1 expression similar to levels in control animals, suggesting that the down-regulation of Cdh1 expression by acupuncture may have a neuroprotective effect. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | Accordingly, the overstimulation of GABAA receptors can potentiate neuronal cell damage; GABA transport blockers are neuroprotective in these situations (, ), suggesting that overexpression of the GABA transporter can damage neurons. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | However, acupuncture stimulation at GB34 and LR3 maintained Slc6a13 gene expression at levels similar to those in control animals, suggesting that acupuncture has a neuroprotective effect. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | Therefore, the maintenance by acupuncture stimulation of expression levels of Itih2 and Serping1, which are involved in neuroinflammation, similar to those in control animals suggests that acupuncture may have a neuroprotective effect. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | Increasing pro-line levels in ECF may induce neuronal cell death, suggesting that down-regulation of Slc6a20a gene expression following acupuncture may have a neuroprotective effect. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | However, further evidence is needed to confirm this, and the maintenance of Rdh9 expression following acupuncture may have neuro-protective effects. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25983633 | The neuroprotective effects of acupuncture have been confirmed at a genetic level. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Neuroprotection | Mechanism |
| 25878596 | Our results suggest that acupuncture has a neuroprotective effect on cerebral hemorrhage by inhibiting Notch-Hes signaling pathway transduction in rat basal ganglia after cerebral hemorrhage. | Neural Regen Res. 2015 Mar;10(3):457-62. doi: 10.4103/1673-5374.153696. | Neuroprotection Bleeding | Mechanism |
| 35251208 | Neuroprotective Effect of Acupuncture against Single Prolonged Stress-Induced Memory Impairments and Inflammation in Rat Brain via Modulation of Brain-Derived Neurotrophic Factor Expression | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Neuroprotection | Mechanism |
| 25767501 | To further explore its mechanism, this study confirmed that electroacupuncture was able to increase the expression of p70S6 kinase and ribosomal protein S6 in the hippocampus of VD rats, which might protect neurons and facilitate long-term potentiation in the hippocampus. | Neural Regen Res. 2012 Jan 25;7(3):207-11. doi: 10.3969/j.issn.1673-5374.2012.03.009. | Neuroprotection | Mechanism |
| 26889195 | Indeed, increased GDNF expression has a neuroprotective effect and promotes recovery of motor neuron function (Yuan et al., 2007; Koeberle and Bahr, 2008; Naoi and Maruyama, 2009), consistent with the present study. | Neural Regen Res. 2015 Dec;10(12):2033-9. doi: 10.4103/1673-5374.172323. | Neuroprotection | Mechanism |
| 27630692 | Our results indicate that electroacupuncture at Baihui and Shuigou increases the serum level of TGF-β1 in rats with acute cerebral ischemia/reperfusion injury, and exerts neuroprotective effects. | Neural Regen Res. 2016 Jul;11(7):1099-101. doi: 10.4103/1673-5374.187042. | Neuroprotection | Mechanism |
| 27630692 | These are all important effects in neuroprotection, nerve regeneration, synaptic remodeling and angiogenesis after ischemic cerebrovascular disease. | Neural Regen Res. 2016 Jul;11(7):1099-101. doi: 10.4103/1673-5374.187042. | Neuroprotection | Mechanism |
| 25767502 | Estrogen has a neuroprotective effect in the central nervous system and also plays an important role in modulation of hippocampal functions with regard to cell morphology, synapse formation, signaling, and excitability. | Neural Regen Res. 2012 Jan 25;7(3):212-8. doi: 10.3969/j.issn.1673-5374.2012.03.010. | Neuroprotection | Mechanism |
| 33229729 | These results indicate that other effector pathways are also involved in the neuroprotective effects of PEA. | Neural Regen Res. 2021 May;16(5):916-923. doi: 10.4103/1673-5374.297090. | Neuroprotection | Mechanism |
| 28357997 | Acupuncture therapy can influence the ratio between BCL-2 and BAX, suppress apoptosis, and exert a neuroprotective function in perihematomal brain tissue upon acute cerebral hemorrhage. | Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. | Neuroprotection Bleeding | Mechanism |
| 28357997 | reviewed the neuroprotective effect of electroacupuncture (EA) on cerebral ischemic strokes, and clarified that EA could reduce the brain damage caused by cerebral ischemic strokes and induce cerebral ischemic tolerance before the occurrence of cerebral stroke. | Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. | Neuroprotection | Mechanism |
| 28357997 | This study indicates that by ameliorating the changes in the mRNA expression of the apoptotic factors BCL-2 and BAX caused by acute cerebral hemorrhage, acupuncture therapy exerts a neuroprotective function in perihematomal brain tissue upon acute cerebral hemorrhage. | Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. | Neuroprotection Bleeding | Mechanism |
| 30505267 | Conclusion: We propose that EA contributes to neuroprotection by inhibiting PTEN and p53 expression and by increasing the levels of pmTOR/Akt/Erk and of MBP after SCI. | Front Mol Neurosci. 2018 Nov 16;11:411. doi: 10.3389/fnmol.2018.00411. eCollection 2018. | Neuroprotection | Mechanism |
| 30505267 | In addition, we show that EA influences activities of Akt, Bad and caspases, which mediate neuritogenesis and neuroprotection and are specifically and differentially triggered by activation of L1 (Kilic et al.,). | Front Mol Neurosci. 2018 Nov 16;11:411. doi: 10.3389/fnmol.2018.00411. eCollection 2018. | Neuroprotection | Mechanism |
| 30505267 | Enhanced mTOR activity reduces death of motor neurons, protects the damaged nerve tissue, reduces formation of syringomyelia after SCI and contributes to repair (Wang et al.,). | Front Mol Neurosci. 2018 Nov 16;11:411. doi: 10.3389/fnmol.2018.00411. eCollection 2018. | Neuroprotection | Mechanism |
| 31871478 | The combined treatment also had a neuroprotective effect via the PI3K/AKT and MAPK/ERK signaling pathways. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | Other researchers have reported that acupuncture at GB34 has a neuroprotective effect on dopaminergic neurons in a PD animal model. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | As discussed by Bae et al., two herbal medicines have been shown to exhibit neuroprotective effects by enhancing autophagy. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | Other herbal medicines have a neuroprotective effect on dopaminergic neurons and improve motor symptoms by inhibiting oxidative stress and cell death and by improving mitochondrial dysfunction. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | The modified form of Chunggantang (KD5040) is widely used in Traditional Oriental Medicine and has many effects, including anti-inflammatory and neuroprotective properties, improvement of motor function, decreasing the dose of levodopa, and relieving LID. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection Motor Function | Mechanism |
| 31871478 | High-dose KD5040 had a greater neuroprotective effect than low-dose KD5040, so it was inappropriate to use high-dose KD5040 investigating the synergistic effect of the combined treatment. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | Effect of the Combined Treatment on the Expression of Proteins Related to the Neuroprotective Effect | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | We found that the combined treatment had a synergistic effect on motor function enhancement and a neuroprotective effect on dopaminergic neurons compared with the use of acupuncture or KD5040 alone. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection Motor Function | Mechanism |
| 31871478 | To determine how the combined treatment exhibited a neuroprotective effect, we investigated changes in neuroprotection-related protein expression in the SNpc by western blot. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | AKT has been linked to a variety of cell functions, such as survival, growth, death, differentiation, transcription, and migration and has a neuroprotective effect on dopaminergic neurons. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | reported that the electroacupuncture treatment at GB34 and LR3 had neuroprotective effects modulating BDNF and AKT pathways. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | Phosphorylation of ERK was suppressed by MPTP treatment, but activation of ERK increased significantly in response to the combined treatment, suggesting that the MEK/ERK pathway is involved in the neuroprotective effect of the combined treatment. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | The combined treatment has antiapoptosis and neuroprotective effects on dopaminergic cells. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | We identified the mechanism of the synergistic effect through expression of neuroprotective proteins, but further study is necessary to examine whether the combined treatment increases the level and availability of reduced dopamine. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | It suppresses α-synuclein expression, thereby having neuroprotective effects. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | It has an antioxidant effect, has shown neuroprotective effects in the PD mouse model, and inhibits monoamine oxidase (MAO) activity. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 31871478 | The combined treatment of acupuncture and low-dose KD5040 exhibited a synergistic effect on abnormal motor function and neuroprotection compared with treatment with acupuncture or KD5040 alone. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection Motor Function | Mechanism |
| 31871478 | Moreover, the neuroprotective effect of dopaminergic neurons occurred via activation of the PI3K/AKT/GSK3β and MEK/ERK pathways. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Neuroprotection | Mechanism |
| 27852302 | The aim of the present study was to investigate whether the neuroprotective effects of electroacupuncture (EA) are mediated by anti-neuroinflammatory effects in a rat model of TBI. | BMC Complement Altern Med. 2016 Nov 16;16(1):470. doi: 10.1186/s12906-016-1457-6. | Neuroprotection | Mechanism |
| 27852302 | Recently, we have demonstrated that application of EA 60Â min post-TBI has neuroprotective effects on neuronal cells. | BMC Complement Altern Med. 2016 Nov 16;16(1):470. doi: 10.1186/s12906-016-1457-6. | Neuroprotection | Mechanism |
| 27852302 | previously reported that EA at 2Â Hz (low frequency) can provide neuroprotection by preserving retinal function in glaucomatous rats. | BMC Complement Altern Med. 2016 Nov 16;16(1):470. doi: 10.1186/s12906-016-1457-6. | Neuroprotection | Mechanism |
| 33193035 | However, more and more evidence suggests that the immune responses can also serve to protect the injured area from further insult by engulfing pathogens, removing cell debris, exerting repair, and neuroprotection mechanisms. | Front Neurol. 2020 Oct 30;11:580997. doi: 10.3389/fneur.2020.580997. eCollection 2020. | Immunity Neuroprotection | Mechanism |
| 30106055 | Thus, decreasing brain edema is critical for protecting neurovascular structures. | Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. | Neuroprotection | Mechanism |
| 37179843 | BDNF enhances the release of neurotransmitters to protect neuroplasticity and promotes cannabinoid-mediated neurogenesis. | Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. | Neuroprotection | Mechanism |
| 27073385 | Manual acupuncture at the SJ5 (Waiguan) acupoint shows neuroprotective effects by regulating expression of the anti-apoptotic gene Bcl-2 | Neural Regen Res. 2016 Feb;11(2):305-11. doi: 10.4103/1673-5374.177740. | Neuroprotection | Mechanism |
| 27073385 | Acupuncture at the SJ5 (Waiguan) acupoint has neuroprotective effects in cerebral infarction, but the underlying mechanism remains poorly understood. | Neural Regen Res. 2016 Feb;11(2):305-11. doi: 10.4103/1673-5374.177740. | Neuroprotection | Mechanism |
| 27073385 | These findings indicate that acupuncture at SJ5 exerts neuroprotective effects by regulating the expression of anti-apoptotic gene Bcl-2. | Neural Regen Res. 2016 Feb;11(2):305-11. doi: 10.4103/1673-5374.177740. | Neuroprotection | Mechanism |
| 27073385 | Our present findings suggest that acupuncture at SJ5 can initiate protein changes in the cerebellum related to neuroprotection, and this effect may last from 20 minutes to 2 hours after treatment. | Neural Regen Res. 2016 Feb;11(2):305-11. doi: 10.4103/1673-5374.177740. | Neuroprotection | Mechanism |
| 27073385 | Together, this evidence supports the theory that acupuncture stimulation has neuroprotective effects and can mediate anti-apoptosis. | Neural Regen Res. 2016 Feb;11(2):305-11. doi: 10.4103/1673-5374.177740. | Neuroprotection | Mechanism |
| 29311503 | To exclude influences of anesthesia in EA treatment, such as central sedation and possible neuroprotection or neural injury, we designed a restriction device (Patent application No. | Exp Anim. 2018 May 10;67(2):271-280. doi: 10.1538/expanim.17-0142. Epub 2018 Jan 1. | Neuroprotection Sedation | Mechanism |
| 26064176 | Acupuncture has been demonstrated to exert a neuroprotective effect on several diseases especially for painful diseases. | Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29. | Neuroprotection | Mechanism |
| 25206919 | Our results suggest that the mechanism underlying the neuroprotective effect of acupuncture and moxibustion in Alzheimer's disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway. | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Neuroprotection | Mechanism |
| 25206919 | The present study demonstrates that electroacupuncture pretreatment has a neuroprotective function in the hippocampus, suggesting that this technique could be used to protect learning and memory functions, and prevent senile dementia. | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Neuroprotection Learning and Memory Ability | Mechanism |
| 25206919 | The combination of moxibustion and electroacupuncture obtained a better neuroprotective effect than either technique alone, and can be applied in the clinic. | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Neuroprotection | Mechanism |
| 23837037 | However, the precise mechanism of its neuroprotective activities remains largely unknown. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 23837037 | The present data suggest that EA at the Quchi and Zusanli acupoints exerts a neuroprotective effect in ischemic stroke via the activation of ERK signaling. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 23837037 | However, the precise mechanism of the neuroprotective effect remains to be elucidated. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 23837037 | In present study, a focal cerebral I/R-injured rat model was used to elucidate the neuroprotective mechanism of electroacupuncture (EA) at the Quchi and Zusanli acupoints, evaluate the therapeutic efficacy of EA against ischemic stroke and investigate its effect on the ERK pathway. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 23837037 | The neuroprotective effect of EA was first evaluated by measuring the neurological deficit scores. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 23837037 | However, the mode of action of the neuroprotective activities of EA remain poorly understood. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 23837037 | In the present study, a focal cerebral I/R rat model was used to demonstrate that EA at Zusanli and Quchi for only 24 h had a neuroprotective effect as evidenced by improved neurological deficits and reduced cerebral infarct volume. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 23837037 | In conclusion, to the best of our knowledge, the present study reported for the first time that EA at the Quchi (LI11) and Zusanli (ST36) acupoints exerts a neuroprotective effect in ischemic stroke via the activation of the ERK1/2 pathway. | Exp Ther Med. 2013 Jun;5(6):1593-1597. doi: 10.3892/etm.2013.1030. Epub 2013 Mar 26. | Neuroprotection | Mechanism |
| 34804173 | Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling and neuronal nuclear protein (NeuN) double staining and cellular inhibitor of apoptosis protein-1 (cIAP1) and NeuN immunofluorescence double staining were used to detect the short-term and long-term neuroprotective effects of scalp acupuncture combined with treadmill training on pMCAO rats. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Immunity Neuroprotection | Mechanism |
| 34804173 | Systematic evidence has suggested that Baihui (GV20)-based scalp acupuncture is beneficial in the treatment of ischemic stroke as it improves infarct volume and neurological function scores and exerts a potential neuroprotective role in experimental ischemic stroke. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 34804173 | The neuronal expression level of cellular inhibitor of apoptosis protein-1 (cIAP1), which is considered the key target of neuroprotection induced by ischemic preconditioning, was examined in vivo to further investigate the regulatory effects of scalp acupuncture combined with treadmill training therapy in inhibiting neuronal apoptosis and neuroprotection. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 34804173 | It is noteworthy that SA-T was more neuroprotective than SA and TT (Figure 2(d)). | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 34804173 | This further indicates that SA-T mainly plays a neuroprotective role by targeting cIAP1. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 34804173 | It was also confirmed that the expression of cIAP1 in primary cultured cortical neurons treated with glutamic acid was significantly decreased, and upregulation of cIAP1 could significantly inhibit apoptosis induced by glutamic acid and thus play a neuroprotective role. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 34804173 | First of all, this study only explored the neuroprotective mechanism of scalp acupuncture combined with treadmill training therapy from the aspect of nerve apoptosis. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 34804173 | In conclusion, we first report the neuroprotective effect of cIAP1 in ischemic stroke. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 34804173 | SA-T plays a neuroprotective role through the caspase-independent pathway by upregulating the expression of cIAP1. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Neuroprotection | Mechanism |
| 25810743 | Experimental studies have shown that acupuncture provides neuroprotection with antioxidation and antiapoptosis effects through stimulating the specific acupoints. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Neuroprotection | Mechanism |
| 25206816 | Glial cell line-derived neurotrophic factor has been shown to protect neurons against injury, and also contributes to axon growth. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Neuroprotection | Mechanism |
| 34108361 | Although the neuroprotective effect of DU20-penetrating-GB7 acupuncture is basically clear, few research teams pay close attention to its mechanism on ICH. | Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. | Neuroprotection | Mechanism |
| 34108361 | 1A, neurological deficits were alleviated with Baihui-penetrating-Qubin acupuncture treatment, however, the neuroprotective effects could be counteracted by miR-34a-5p overexpression (P<0.05). | Exp Anim. 2021 Nov 10;70(4):469-478. doi: 10.1538/expanim.21-0034. Epub 2021 Jun 10. | Neuroprotection | Mechanism |
| 30028333 | The adjunctive therapies, such as corticosteroids (Fehlings et al., 2014; Schroeder et al., 2014) and neuroprotectant agents (Wilson et al., 2013; Grossman et al., 2014), have some protective effect on the spinal cord and nerve roots, but the overall effects are not ideal. | Neural Regen Res. 2018 Jul;13(7):1241-1246. doi: 10.4103/1673-5374.235062. | Neuroprotection | Mechanism |
| 30028333 | Also, Governor Vessel electroacupuncture (EA) has been proven to prevent secondary damage and to improve neuroprotective effects after SCI (Liu et al., 2011; Juarez Becerril et al., 2015; Wei et al., 2017). | Neural Regen Res. 2018 Jul;13(7):1241-1246. doi: 10.4103/1673-5374.235062. | Neuroprotection | Mechanism |
| 28761425 | Studies have found that acupuncture treatment reduces ischemia/reperfusion injury through multiple paths and targets (Feng et al., 2013; Liu et al., 2015a; Jin et al., 2016), and that it has multiple functions such as reducing inflammation, neuron protection, and promoting the repair of damaged neurons (Yang et al., 2012). | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Neuroprotection | Mechanism |
| 25120577 | Coincidences with the result of clinic trial, animal researches also demonstrate a neuroprotective effect on MCAO rats treated by acupuncture, which is relative to increased brain blood flow, reduced ischemic infarction volume, and lowered neuronal cell death rate in acupuncture group under the proper stimulated parameter on special acupoint. | Evid Based Complement Alternat Med. 2014;2014:962343. doi: 10.1155/2014/962343. Epub 2014 Jul 10. | Neuroprotection Blood Flow | Mechanism |
| 25120577 | As evidences given by recently extensive reports, the beneficial effects of acupuncture on brain ischemic damage in vivo or in vitro mainly focus on microcirculation, anti-apoptotic, anti-inflammation, neuron protection, brain metabolism. | Evid Based Complement Alternat Med. 2014;2014:962343. doi: 10.1155/2014/962343. Epub 2014 Jul 10. | Brain Protection Neuroprotection Microcirculation | Mechanism |
| 25120577 | Our previous studies indicated that acupuncture combined with basic modern medicine treatment showed a great effect on stroke patients' self-care ability and quality of life in clinic trial, and the underlying mechanism may be associated with improving cerebral haemodynamics and neuron protective effect under a special stimulated parameter on a special acupionts revealed by animal researches. | Evid Based Complement Alternat Med. 2014;2014:962343. doi: 10.1155/2014/962343. Epub 2014 Jul 10. | Neuroprotection | Mechanism |
| 25120577 | Given the results mentioned above, we speculate that acupuncture may achieve neuroprotection by enhancing self-repairing capacity which increases cerebral blood flow to create an appropriate microenvironment for subsequent proliferation and migration of neural stem cell towards the ischemic boundary region to replenish damaged neuron. | Evid Based Complement Alternat Med. 2014;2014:962343. doi: 10.1155/2014/962343. Epub 2014 Jul 10. | Neuroprotection Blood Flow | Mechanism |
| 25120577 | Here, we found out that high expression of GSK-3β and suppression of PP2A were evoked by ischemia damage but regulated by acupuncture treatment in vivo, which suggests that mechanism of acupuncture neuroprotection may be associated with regulation GSK-3β and PP2A expression. | Evid Based Complement Alternat Med. 2014;2014:962343. doi: 10.1155/2014/962343. Epub 2014 Jul 10. | Neuroprotection | Mechanism |
| 25624811 | The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | Increased transforming growth factor-beta 1 protein levels may act as an initiator of neuroprotective mechanisms. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | Bcl-2 is a known oncogene product that protects cells from apoptosis by preventing the release of cytochrome C. Increased Bcl-2 expression is also neuroprotective because it decreases the formation of peroxynitrite and nitric oxide, thereby reducing infarct volume and inhibiting the activation of caspase-3. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | As described above, the increased production of transforming growth factor-beta 1 and Bcl-2 has been shown to be neuroprotective against cerebral ischemia. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | Therefore, pre-ischemia electro-acupuncture may have a beneficial effect in neuroprotection after cerebral ischemia by upregulating the content of transforming growth factor-beta 1. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | The neuroprotection may take place in penumbral region of the cerebral cortex and striatum where the elevated expression of transforming growth factor-beta 1 mRNA following occlusion of middle cerebral artery was reported recently. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | Bcl-2 also plays an important role in neuroprotection in cerebral ischemia. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | The neuronal protection controlled by Bcl-2 is through the inhibition of free radical production, cytosolic accumulation of cytochrome C and caspase-3 activation. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | In contrast of our previous study, pre-ischemia electro-acupuncture at GB20 showed that malondialdehyde production was inhibited suggesting that different acupoints may exert neuronal protection through different biochemical pathways. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | Data from this study confirmed that multiple pre-injury electro-acupuncture stimulations at ST36 could effectively increase the production of both transforming growth factor-beta 1 and Bcl-2, with an up-regulation of transforming growth factor-beta 1 correlated to a neuroprotective effect at GB20. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |
| 25624811 | In addition, transforming growth factor-beta 1 promotes the neuroprotection of proteins against expected oxidative stress by regulating the apoptotic cascade. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Neuroprotection | Mechanism |