- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Lower Incidence of Side Effects
- Toxic Side Effects
- Acupuncture anesthesia can help reduce the toxic side effects of certain medications used in surgery, minimizing harm to the patient's body.
- Hypothermia
- Acupuncture anesthesia can aid in maintaining normal body temperature during surgery, reducing the risk of hypothermia.
- Stress Response
- Acupuncture anesthesia can mitigate the body's stress response to surgery, promoting a more relaxed and stable physiological state.
- Nausea and Vomiting
- Acupuncture anesthesia has antiemetic properties, effectively preventing postoperative nausea and vomiting.
- Adverse Reactions
- Acupuncture anesthesia can minimize adverse reactions to anesthesia drugs, enhancing patient safety during surgical procedures.
- Side Effects
- Acupuncture anesthesia's minimal side effects make it a safer alternative to traditional anesthesia methods.
- Insomnia
- Acupuncture anesthesia can improve sleep quality by reducing postoperative pain and discomfort.
- Urinary Retention
- Acupuncture anesthesia can help prevent urinary retention, ensuring proper urinary function post-surgery.
- Sleep Quality
- Acupuncture anesthesia contributes to better sleep quality by alleviating pain and promoting relaxation.
- Urinary Incontinence
- Acupuncture anesthesia can address urinary incontinence issues, improving bladder control post-surgery.
Acupuncture anesthesia for Lower Incidence of Side Effects-Side Effects
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 11075428 | Appropriate techniques, hygiene safeguards and knowledge of contraindications will minimize the risks of rare side effects of acupuncture which represents a valuable adjunction to the treatment repertoire in modern neurology. | Wien Med Wochenschr. 2000;150(13-14):278-85. | Side Effects | Review |
| 11246939 | This theory explains the distribution and nonspecific activation of organizing centers and acupuncture points; the high electric conductance of the meridian system; the polarity effect of electroacupuncture; the side-effect profile of acupuncture; and the ontogeny, phylogeny, and physiologic function of the meridian system and chakra system. | J Altern Complement Med. 2001 Feb;7(1):83-91. doi: 10.1089/107555301300004565. | Side Effects | Review |
| 12619444 | It is very important that there are no harms of acupuncture treatment, although mild side effects are possible. | Lijec Vjesn. 2002 Oct;124(10):322-9. | Side Effects | Review |
| 15524070 | Complementary therapies such as acupuncture, mind-body techniques, and massage therapy can help when conventional treatment does not bring satisfactory relief or causes undesirable side effects. | J Support Oncol. 2004 Sep-Oct;2(5):419-26; discussion 427-9. | Side Effects | Review |
| 15673993 | Throughout all the clinical trials reviewed, no side-effects of acupuncture were noted. | J Altern Complement Med. 2004 Dec;10(6):985-1000. doi: 10.1089/acm.2004.10.985. | Side Effects | Review |
| 1581655 | Applications of acupuncture include treatment of inflammation and trauma; stimulation of tissue healing in burns, ulcers, indolent wounds, ischemia, necrosis, and gangrene; infections; postinfection sequelae; fever; autoimmune disease; allergies; anaphylaxis and shock; and treatment or prevention of side effects from cytotoxic chemotherapy and ionizing radiation. | Probl Vet Med. 1992 Mar;4(1):162-93. | Toxic Side Effects Side Effects | Review |
| 1581663 | Acupuncture was found to be beneficial in cases in which analgesics and anti-inflammatory medications have been ineffective or have demonstrated side effects, and in cases in which surgery was not recommended. | Probl Vet Med. 1992 Mar;4(1):88-97. | Side Effects | Review |
| 15911926 | This article will provide current cancer treatment providers with information on acupuncture as well as the research conducted on cancer symptoms and side effects of cancer treatments. | Integr Cancer Ther. 2005 Jun;4(2):131-43. doi: 10.1177/1534735405276419. | Side Effects | Review |
| 15911926 | Despite the immense popularity in the community, few large randomized trials have been conducted to determine the effects acupuncture has on cancer symptoms and side effects of treatments. | Integr Cancer Ther. 2005 Jun;4(2):131-43. doi: 10.1177/1534735405276419. | Side Effects | Review |
| 16092807 | Acupuncture for side effects of chemoradiation therapy in cancer patients. | Semin Oncol Nurs. 2005 Aug;21(3):190-5. doi: 10.1016/j.soncn.2005.04.008. | Side Effects | Review |
| 16092807 | OBJECTIVE: To review strategies and recommendations to improve utilization of acupuncture treatment for side effects of chemoradiation therapy in cancer centers. | Semin Oncol Nurs. 2005 Aug;21(3):190-5. doi: 10.1016/j.soncn.2005.04.008. | Side Effects | Review |
| 17012933 | Low side effect therapies such as cognitive therapy and acupuncture show some benefits but their utility in combination with pharmacotherapies remains to be demonstrated. | Curr Opin Psychiatry. 2006 Nov;19(6):570-4. doi: 10.1097/01.yco.0000245744.60631.84. | Side Effects | Review |
| 18440533 | Despite these deficiencies, acupuncture can be considered as an effective alternative for pain relief during oocyte retrieval in patients who cannot tolerate side effects of conscious sedation. | Fertil Steril. 2008 Jul;90(1):1-13. doi: 10.1016/j.fertnstert.2008.02.094. Epub 2008 Apr 28. | Pain Relief Side Effects Sedation | Review |
| 18522936 | The acupuncture treatment group was associated with a lower incidence of opioid-related side-effects such as nausea (relative risk, RR: 0.67; 95% CI: 0.53, 0.86), dizziness (RR: 0.65; 95% CI: 0.52, 0.81), sedation (RR: 0.78; 95% CI: 0.61, 0.99), pruritus (RR: 0.75; 95% CI: 0.59, 0.96), and urinary retention (RR: 0.29; 95% CI: 0.12, 0.74). | Br J Anaesth. 2008 Aug;101(2):151-60. doi: 10.1093/bja/aen146. Epub 2008 Jun 2. | Side Effects Nausea and Vomiting Urinary Retention Sedation | Review |
| 18652123 | Acupuncture is affirmatively effective in treating obesity with its flexible point selection and various methods without toxic and side effects. | J Tradit Chin Med. 2008 Jun;28(2):139-47. doi: 10.1016/s0254-6272(08)60033-3. | Toxic Side Effects Side Effects | Review |
| 18652337 | Acupuncture as one of TCM therapies with advantages of safety, effectiveness and no side effect is playing an important role in treatment of cancer pain. | Zhongguo Zhen Jiu. 2008 May;28(5):392-4. | Cancer Pain Side Effects | Review |
| 19370841 | Very often acupuncture has mild side-effects and rather rarely serious side-effects or health hazards. | Versicherungsmedizin. 2009 Mar 1;61(1):19-24. | Side Effects | Review |
| 19887992 | However, the effectiveness of acupuncture in treating toxic neuropathy has not been assessed. | Am J Clin Oncol. 2009 Jun;32(3):319-25. doi: 10.1097/COC.0b013e318173a520. | Toxic Side Effects | Review |
| 20209979 | Results indicate that any anesthetic method has its own advantages and disadvantages, while compound acupuncture anesthesia for thyroid surgery is of prominent preponderance not only in the analgesic effect but also in fewer side-effects and less physiological interference. | Zhen Ci Yan Jiu. 2009 Dec;34(6):410-2, 420. | Analgesic Effect Side Effects | Review |
| 20605536 | Acupuncture is safe with minimal side-effects, and is clinically effective for the management of these symptoms. | Auton Neurosci. 2010 Oct 28;157(1-2):96-100. doi: 10.1016/j.autneu.2010.05.001. | Side Effects | Review |
| 21116744 | While debates on methodological problems confronting the study of acupuncture remain, the most recent research demonstrates that acupuncture is safe, tolerable and effective for a range of side effects resulting from conventional cancer treatments. | Curr Treat Options Oncol. 2010 Dec;11(3-4):87-94. doi: 10.1007/s11864-010-0131-3. | Side Effects | Review |
| 21376483 | These reviews evaluated the efficacy of acupuncture for treating the side effects of breast cancer chemotherapy, menstrual disturbances, menopausal symptoms, female infertility, uterine fibroids and polycystic ovary syndrome. | Maturitas. 2011 Apr;68(4):346-54. doi: 10.1016/j.maturitas.2011.02.001. Epub 2011 Mar 3. | Side Effects | Review |
| 21617789 | Therefore standard painkillers, NSAIDs (COX2 inhibitors), week opioids and other interventions (vitamin D, calcium, bisphosphonates, exercise, acupuncture, complementary and alternative approaches, eventually switch to another endocrine drug) are used for managing this treatment-related side effect, and improve adherence and quality of life among breast cancer survivors. | Magy Onkol. 2011 Mar;55(1):32-9. Epub 2011 Mar 31. | Endocrinology Side Effects | Review |
| 21695618 | Compared with the currently available pharmacological interventions, acupuncture therapy has the potential to help drug addicts stay away from drugs without major adverse side effects. | Front Med. 2011 Jun;5(2):141-50. doi: 10.1007/s11684-011-0136-8. Epub 2011 Jun 22. | Side Effects | Review |
| 21701996 | Recently, it has been shown that peripheral sensory stimulation by electroacupuncture (EA) could improve brain NGF availability and utilization, at the same time counteracting the major sideeffects induced by NGF administration. | Arch Ital Biol. 2011 Jun;149(2):247-55. doi: 10.4449/aib.v149i2.1365. | Side Effects | Review |
| 21820545 | Acupuncture is a potential treatment for cancer-induced bone pain (CIBP) as it has few side effects and is relatively easy to administer. | Physiotherapy. 2011 Sep;97(3):256-63. doi: 10.1016/j.physio.2010.08.008. Epub 2010 Oct 30. | Side Effects | Review |
| 22234164 | Acupuncture as well as physical modalities, such as massage or warming of the abdomen, is promising with few side-effects and should be considered as well. | Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):166-73. doi: 10.1097/MCO.0b013e32834f3000. | Side Effects | Review |
| 22419418 | Acupuncture has many beneficial effects during cancer therapy and has proven efficacy in the management of side effects induced by chemotherapy and radiotherapy. | Am J Chin Med. 2012;40(2):219-29. doi: 10.1142/S0192415X12500176. | Side Effects | Review |
| 22762294 | We also examined adverse events associated with acupuncture, and evidence for acupuncture as a means of reducing side effects of ADs. | Can J Psychiatry. 2012 Jul;57(7):397-405. doi: 10.1177/070674371205700702. | Side Effects | Review |
| 22762294 | Manual acupuncture reduced side effects of ADs in MDD. | Can J Psychiatry. 2012 Jul;57(7):397-405. doi: 10.1177/070674371205700702. | Side Effects | Review |
| 23227705 | It turned out that in the area of clinical research, the main usage of acupuncture was assist treatment of artificial abortion and drug-induced abortion: in artificial abortion, acupuncture can play a role in analgesia, artificial abortion syndrome relieving, and cervix dilating, while in the drug induced abortion, acupuncture can play a role in improving completed abortion rate, accelerating foetal sac release, decreasing side effects and regulating postoperative bleeding. | Zhongguo Zhen Jiu. 2012 Sep;32(9):860-4. | Side Effects Bleeding | Review |
| 23650807 | In the present paper, the authors review new progresses of researches on acupuncture analgesia for postoperative pain and side effects in the past few years from thyroidectomy, chest surgery, abdominal surgery, five sense organs (ear, nose, eye and throat) surgery, and others. | Zhen Ci Yan Jiu. 2013 Feb;38(1):83-7. | Side Effects | Review |
| 23650807 | As a common technique widely used in the field of clinical medicine, the underlying mechanisms of acupuncture therapy for relieving post-surgery pain and side-effects should be studied profoundly in the future. | Zhen Ci Yan Jiu. 2013 Feb;38(1):83-7. | Side Effects | Review |
| 23724696 | When compared with conventional medical treatment, the acupuncture therapy shows the obvious advantage of lacking, adverse side effects commonly associated with the Western anti-anginal drugs such as 1) Nitroglycerine (headache--63% with nitroglycerine patch and 50% with spray; syncope--4%; and dizziness--8% with patch; hypotension--4% with patch; and increased angina 2% with patch). | Acupunct Electrother Res. 2013;38(1-2):17-35. doi: 10.3727/036012913x13831831849457. | Side Effects | Review |
| 23724696 | Combination of conventional drug therapy and acupuncture would considerably decrease the frequency and the required dosage of drug taking, thereby decreasing the unpleasant side effects of the drug therapy. | Acupunct Electrother Res. 2013;38(1-2):17-35. doi: 10.3727/036012913x13831831849457. | Side Effects | Review |
| 23818069 | OBJECTIVES: To assess the effectiveness and side effects of acupuncture for stress urinary incontinence in adults. | Cochrane Database Syst Rev. 2013 Jul 1;(7):CD009408. doi: 10.1002/14651858.CD009408.pub2. | Side Effects Urinary Incontinence | Review |
| 24338183 | The effects of acupuncture on different cancer-related aspects were shown, including chemotherapy or radiotherapy-induced side effects (13/33, 39.4%), cancer pain (6/33, 18.2%), post-operative urinary retention (4/33, 12.1%), quality of life (2/33, 6.1%), vasomotor syndrome (2/33, 6.1%), post-operative gastrointestinal dysfunction (2/33, 6.1%), prevention of prolonged postoperative ileus (2/33, 6.1%), joint symptoms (1/33, 3.0%), and immunomodulation (1/33, 3.0%). | Chin J Integr Med. 2014 Feb;20(2):136-47. doi: 10.1007/s11655-013-1439-1. Epub 2013 Dec 13. | Immunity Cancer Pain Side Effects Urinary Retention | Review |
| 24338183 | CONCLUSIONS: The result of our systematic review suggested that the effectiveness of acupuncture in palliative care for cancer patients is promising, especially in reducing chemotherapy or radiotherapyinduced side effects and cancer pain. | Chin J Integr Med. 2014 Feb;20(2):136-47. doi: 10.1007/s11655-013-1439-1. Epub 2013 Dec 13. | Cancer Pain Side Effects | Review |
| 24494306 | And it is approved that acupuncture treatment, which includes body needling, moxibustion, combination of acupuncture and moxibustion, acupoint injection and medication plasters, has reliable effects and less side-effects. | Zhongguo Zhen Jiu. 2013 Nov;33(11):1052-6. | Side Effects | Review |
| 24501113 | Published studies in cancer patients and survivors show that acupuncture treatment is not only safe but also more acceptable with fewer side effects than standard of care pharmacological treatments like antidepressants. | Integr Cancer Ther. 2014 Sep;13(5):371-85. doi: 10.1177/1534735413520181. Epub 2014 Feb 4. | Side Effects | Review |
| 24653050 | Non-pharmacological treatments such as acupuncture may have an adjunctive role in controlling pain without the undesirable side effects of drug regimens and yet the evidence base remains limited. | BMJ Support Palliat Care. 2011 Jun;1(1):51-5. doi: 10.1136/bmjspcare-2011-000022. | Side Effects | Review |
| 24724890 | Other herbal treatments have reversed the cardiac arrhythmias associated with ATS intoxication, and acupuncture has been used successfully for the protracted depressive and somatic symptoms of ATS withdrawal over a period of 3 months. | Am J Addict. 2014 May-Jun;23(3):313-7. doi: 10.1111/j.1521-0391.2014.12116.x. | Toxic Side Effects | Review |
| 26484723 | CONCLUSION: Perioperative acupuncture may provide pain relief without side effects in patients undergoing tonsillectomy. | Laryngoscope. 2016 Mar;126(3):608-15. doi: 10.1002/lary.25721. Epub 2015 Oct 20. | Pain Relief Side Effects | Review |
| 26742319 | Clinical studies in China and Korea, in particular, have shown a positive benefit of acupuncture in treating Parkinson's disease, especially in reducing the doses of dopaminergic medications and the associated side effects. | J Tradit Chin Med. 2015 Dec;35(6):709-17. doi: 10.1016/s0254-6272(15)30164-3. | Side Effects | Review |
| 26906261 | Acupuncture is safe, has minimal detrimental side effects, and is well tolerated by most horses. | Vet Clin North Am Equine Pract. 2016 Apr;32(1):73-85. doi: 10.1016/j.cveq.2015.12.004. Epub 2016 Feb 20. | Side Effects | Review |
| 26963020 | A trained physician can rapidly use certain acupuncture techniques in an austere environment with potentially fewer side effects. | Curr Sports Med Rep. 2016 Mar-Apr;15(2):111-5. doi: 10.1249/JSR.0000000000000240. | Side Effects | Review |
| 27141629 | Results indicate that scalp acupuncture intervention can 1) improve cerebral blood circulation to promote regional energy metabolism, 2) up-regulate expression of glial cell-line derived neurotrophic factor (GDNF), etc., possibly promoting proliferation and differentiation of neural stem cells in the focal cerebral cortex and hippocampus, 3) reduce contents of excitatory amino acid and increase level of gamma-aminobutyric acid (GABA) to lower neurogenic toxicity, and relieve cerebral injury, 4) ease cerebral vascular immunoinflammatory reactions, 5) regulate blood lipid metabolism to resist cerebral free radical damage, and 6) inhibit cerebral cortical apoptosis. | Zhen Ci Yan Jiu. 2016 Feb;41(1):87-9, 93. | Immunity Toxic Side Effects Circulation | Review |
| 27323449 | Ischemic Stroke, Excitatory Amino Acids Toxicity and the Adjustment of Acupuncture Intervention. | Zhen Ci Yan Jiu. 2016 Apr;41(2):180-5. | Toxic Side Effects | Review |
| 27323449 | In this paper the authors introduce the research status of antiexcitatory amino acids toxicity effect of acupuncture in ischemic stroke animals by summarizing its effects on subunits of ionotropic glutamate receptor (NMDA/AMPA) and metabotropic glutamate receptors (mGluRs), and on astrocyte activities. | Zhen Ci Yan Jiu. 2016 Apr;41(2):180-5. | Toxic Side Effects | Review |
| 27323449 | Results indicated that acupuncture intervention may down-regulate the expression levels of cerebral multi-types (NR 1, NR 2 B) of glutamate NMDA receptors, up-regulate expression of glutamate transporter-1, NR 2 A, cannabinoid receptor (CBR) type 1 and 2, and suppress activities of cerebral astrocytes, reduce the content of extracellular glutamate to lower its toxicity and to improve stroke at last. | Zhen Ci Yan Jiu. 2016 Apr;41(2):180-5. | Toxic Side Effects | Review |
| 27924797 | The blood pressure-lowering effect of acupuncture alone is controversial but worthy of exploration, considering the side effects of and the problems of low adherence to drugs. | Forsch Komplementmed. 2016;23(6):351-355. doi: 10.1159/000452984. Epub 2016 Dec 8. | Side Effects Blood Pressure | Review |
| 27924797 | The third patient, who refused to take antihypertensive drugs because of their side effects, received acupuncture treatment of 46 sessions over 2 months, which reduced his blood pressure from 150/90 to 120/80 mm Hg. | Forsch Komplementmed. 2016;23(6):351-355. doi: 10.1159/000452984. Epub 2016 Dec 8. | Side Effects Blood Pressure | Review |
| 28395101 | CONCLUSIONS: Ear acupuncture may be a promising modality to be used for pain reduction within 48 hours, with a low side effect profile. | Pain Med. 2017 Mar 1;18(3):551-564. doi: 10.1093/pm/pnw215. | Side Effects | Review |
| 28527041 | Acupuncture regulates multiple molecules and signaling pathways that lead to excitoxicity, oxidative stress, inflammation, neurons death and survival. | J Neuroimmune Pharmacol. 2017 Dec;12(4):575-592. doi: 10.1007/s11481-017-9747-4. Epub 2017 May 19. | Toxic Side Effects | Review |
| 28748654 | Our primary aim was to assess the efficacy of acupuncture in the emergency setting while secondary objectives were to explore its suitability through its side-effect profile, patient satisfaction, cost, administration time and points used. | Emerg Med Australas. 2017 Oct;29(5):490-498. doi: 10.1111/1742-6723.12832. Epub 2017 Jul 26. | Side Effects | Review |
| 29619620 | Current literature does not support the routine use of acupuncture for improving pain or quality of life in FM; however, given its benign side effect profile, it should not be discouraged. | Curr Pain Headache Rep. 2018 Apr 4;22(5):33. doi: 10.1007/s11916-018-0688-2. | Side Effects | Review |
| 29705474 | Overall, there is good scientific evidence encouraging acupuncture therapy to treat anxiety disorders as it yields effective outcomes, with fewer side effects than conventional treatment. | Complement Ther Clin Pract. 2018 May;31:31-37. doi: 10.1016/j.ctcp.2018.01.008. Epub 2018 Jan 31. | Side Effects Anxiety | Review |
| 30007828 | Meanwhile, acupuncture was more tolerated than medication because of less side effect reports (RR = 0.29; 95% CI: 0.17-0.51; P < 0.0001). | J Integr Med. 2018 Sep;16(5):312-321. doi: 10.1016/j.joim.2018.06.002. Epub 2018 Jun 28. | Side Effects | Review |
| 30707414 | Clinical trials were well carried out on acupuncture curative effect of tumor complications and side effects of chemo-radiotherapy, but the potential mechanisms have not been clarified. | Chin J Integr Med. 2020 Apr;26(4):310-320. doi: 10.1007/s11655-019-3150-3. Epub 2019 Feb 1. | Side Effects | Review |
| 32138535 | Acupuncture is being used more widely and with a growing number of people in the treatment of pain because it is safer and has fewer side effects. | Am J Chin Med. 2020;48(2):245-258. doi: 10.1142/S0192415X20500135. Epub 2020 Mar 5. | Side Effects | Review |
| 32951719 | Few trials reported on safety outcomes, one trial of acupuncture reported one case of placental abruption and three cases of acupuncture related side effects. | Complement Ther Med. 2020 Aug;52:102469. doi: 10.1016/j.ctim.2020.102469. Epub 2020 Jun 6. | Side Effects | Review |
| 33131633 | There are minimal to no side effects with the use of acupuncture and acupressure for the treatment of nausea and vomiting. | Nurs Clin North Am. 2020 Dec;55(4):571-580. doi: 10.1016/j.cnur.2020.07.001. Epub 2020 Oct 14. | Side Effects Nausea and Vomiting | Review |
| 33131633 | Providers should be encouraged to discuss the efficacy, benefits, and side-effect profile of acupuncture and acupressure with patients who suffer from nausea and vomiting. | Nurs Clin North Am. 2020 Dec;55(4):571-580. doi: 10.1016/j.cnur.2020.07.001. Epub 2020 Oct 14. | Side Effects Nausea and Vomiting | Review |
| 33636511 | Acupuncture having bidirectional regulatory ability and a much lower incidence of side effects can prevent disease. | Neuropeptides. 2021 Jun;87:102132. doi: 10.1016/j.npep.2021.102132. Epub 2021 Feb 19. | Side Effects | Review |
| 33957493 | Side effects were minor and rarely reported on acupuncture. | Complement Ther Clin Pract. 2021 Aug;44:101396. doi: 10.1016/j.ctcp.2021.101396. Epub 2021 Apr 23. | Side Effects | Review |
| 34371213 | BACKGROUND: Acupuncture is considered as an effective alternative treatment for post-stroke depression because of its low side effects and easy availability. | Complement Ther Clin Pract. 2021 Nov;45:101471. doi: 10.1016/j.ctcp.2021.101471. Epub 2021 Aug 4. | Side Effects Depression | Review |
| 34421064 | Some Chinese herbal medicines (e.g., Panax ginseng, Panax quinquefolius, Astragali radix, Bu-zhong-yi-qi-tang (TJ-41), Liu-jun-zi-tang (TJ-43), Shi-quan-da-bu-tang (TJ-48), and Ban-xia-xie-xin-tang (TJ-14)) and some acupuncture points (e.g., Zusanli (ST36), Zhongwan (CV12), Neiguan (PC6) and Baihui (GV20)) that are commonly used to treat cancer-related symptoms and/or to reduce the toxicity of chemotherapy, radiotherapy, or targeted-therapy are highlighted and summarized. | Biosci Trends. 2021 Nov 21;15(5):283-298. doi: 10.5582/bst.2021.01318. Epub 2021 Aug 20. | Toxic Side Effects | Review |
| 34623754 | Clinical studies have shown that acupuncture is an effective therapy without obvious side effects compared to limited efficacy and adverse reactions of drug therapy, cognitive behavioral therapy, and neuromodulation technology in treating depression. | Anat Rec (Hoboken). 2021 Nov;304(11):2436-2453. doi: 10.1002/ar.24783. Epub 2021 Oct 8. | Side Effects Adverse Reactions Depression | Review |
| 34772331 | Results of meta-analysis showed that compared with HT, acupuncture significantly improved clinical effective rate (RR = 1.09, 95% CI 1.03 to 1.16, [Formula: see text] = 0.005), decreased the Kupperman index (WMD = -2.55, 95% CI = -2.93 to -2.17, [Formula: see text] < 0.00001) and the incidence of side effects (RR = 0.14, 95% CI = 0.06-0.32, [Formula: see text] < 0.00001). | Am J Chin Med. 2021;49(8):1793-1812. doi: 10.1142/S0192415X21500853. Epub 2021 Nov 12. | Side Effects | Review |
| 35128875 | It is found that acupuncture induced amelioration of symptoms of CIS is closely related to its functions in 1) inhibiting neuroinflammation, 2) reducing oxidative stress, 3) lowering excitatory amino acid toxicity, 4) resisting neuronal apoptosis, 5) regulating cellular autophagy, 6) promoting neuronal regeneration and repair, 7) facilitating vascular remodeling, 8) regulating cerebrovascular reserve, 9) adjusting brain metabolism, and 10) maintaining the integrity of blood-brain barrier. | Zhen Ci Yan Jiu. 2022 Jan 25;47(1):78-82. doi: 10.13702/j.1000-0607.201026. | Toxic Side Effects | Review |
| 35459333 | Acupuncture seems to be an effective and safe treatment method for many of the cancer symptoms or the side effects of cancer treatment, but, like any other treatment method, it has its indications and contraindications. | Klin Onkol. 2022 Spring;35(2):94-99. doi: 10.48095/ccko202294. | Side Effects | Review |
| 35482244 | Acupuncture is a low-risk method that has the potential to enhance perioperative analgesia, decrease opioid requirement, and reduce unwanted side effects of anesthesia, surgery, and opioid administration such as nausea/vomiting. | Curr Pain Headache Rep. 2022 Jun;26(6):453-458. doi: 10.1007/s11916-022-01048-4. Epub 2022 Apr 28. | Side Effects Nausea and Vomiting Acupuncture Anesthesia Effect | Review |
| 35595611 | Analysis of the 16 RCTs showed that, compared with antidepressants alone, acupuncture along with antidepressants reduced the Hamilton Depression Rating Scale-17 (HAMD-17) scores (standard mean difference [SMD] -0.44, 95% confidence interval [CI] -0.55 to -0.33, P < 0.01; I(2) = 14%), Self-rating Depression Scale (SDS) scores (SMD -0.53, 95% CI -0.84 to -0.23, P < 0.01; I(2) = 79%), and the Side Effect Rating Scale (SERS) scores (SMD -1.11, 95% CI -1.56 to -0.66, P < 0.01; I(2) = 89%). | J Integr Med. 2022 Jul;20(4):305-320. doi: 10.1016/j.joim.2022.05.002. Epub 2022 May 6. | Side Effects Depression | Review |
| 36048280 | CONCLUSIONS: This review is the first snapshot of the landscape of acupuncture clinical trials registered in international trial registries, providing a methodological basis for the management of common treatment- and disease-related side effects among cancer patients undergoing acupuncture and offering useful information that will guide future acupuncture-focused research. | Support Care Cancer. 2022 Dec;30(12):10461-10470. doi: 10.1007/s00520-022-07331-9. Epub 2022 Sep 1. | Side Effects | Review |
| 37382085 | RELEVANCE TO CLINICAL PRACTICE: Acupuncture treatments could act by minimising the side effects of conventional treatments and reducing symptoms induced by tumours. | J Clin Nurs. 2023 Oct;32(19-20):6917-6933. doi: 10.1111/jocn.16812. Epub 2023 Jun 29. | Side Effects | Review |
| 37805054 | CONCLUSION: According to this meta-analysis, acupuncture therapy significantly improved the clinical efficacy of pain intensity, pain changes, and clinical neuropathy in patients with DNP, improved the quality of life of patients to a certain extent, and had lower side effects. | Complement Ther Med. 2023 Nov;78:102992. doi: 10.1016/j.ctim.2023.102992. Epub 2023 Oct 5. | Side Effects | Review |
| 19370583 | No side effects were observed for patients receiving acupuncture; acupressure, in several trials; or transcutaneous electro-acupoint stimulation by a peripheral nerve stimulator. | Cochrane Database Syst Rev. 2009 Apr 15;(2):CD003281. doi: 10.1002/14651858.CD003281.pub3. | Side Effects | Review |
| 23055010 | Acupuncture is relatively safe but there are still reports of serious and fatal side effects that must be taken into account when recommending this therapy. | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Side Effects | Review |
| 23055010 | Acupuncture is relatively safe but there are still reports of serious and fatal side effects that must be taken into account when recommending this therapy to our patients. | Curr Rheumatol Rep. 2012 Dec;14(6):589-97. doi: 10.1007/s11926-012-0295-x. | Side Effects | Review |
| 23338773 | Clinically, the role of acupuncture applying to cancer pain management is twofold: one is to use acupuncture, along with opioids, to alleviate specific cancer pain conditions; the second is to use acupuncture to minimize opioid-related side effects including opioid-induced constipation, pruritus, and nausea/vomiting. | Curr Pain Headache Rep. 2013 Mar;17(3):321. doi: 10.1007/s11916-013-0321-3. | Cancer Pain Side Effects Nausea and Vomiting | Review |
| 23338773 | Acupuncture may reduce postoperative opioid consumption and reduce opioid-related side effects. | Curr Pain Headache Rep. 2013 Mar;17(3):321. doi: 10.1007/s11916-013-0321-3. | Side Effects | Review |
| 23338773 | The acupuncture treatment group was associated with a lower incidence of opioid-related side-effects such as nausea (RR: 0.67; 95% CI: 0.53, 0.86), dizziness (RR: 0.65; 95% CI: 0.52, 0.81), sedation (RR: 0.78, 95% CI: 0.61, 0.99), pruritus (RR: 0.75; 95% CI: 0.59, 0.96), and urinary retention (RR: 0.29: 95% CI: 0.12, 0.74). | Curr Pain Headache Rep. 2013 Mar;17(3):321. doi: 10.1007/s11916-013-0321-3. | Side Effects Nausea and Vomiting Urinary Retention Sedation | Review |
| 23338773 | The author concluded that both the noninvasive and the invasive acupuncture stimulation methods seemed to prevent PONV with minimal side effects. | Curr Pain Headache Rep. 2013 Mar;17(3):321. doi: 10.1007/s11916-013-0321-3. | Side Effects | Review |
| 23338773 | A RCT (n = 69) conducted in China investigated the effects of acupuncture on morphine-induced side effects including nausea, vomiting and pruritus. | Curr Pain Headache Rep. 2013 Mar;17(3):321. doi: 10.1007/s11916-013-0321-3. | Side Effects Nausea and Vomiting | Review |
| 35313481 | Acupuncture can provide analgesia by releasing endogenous opioids with a few side effects and high safety and could be an effective alternative therapy for analgesia to the clinical use rate of drugs to avoid potential adverse events caused by medicines. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Side Effects | Review |
| 35313481 | As a safe analgesic therapy with low side effects and low economic burden, acupuncture has a lower incidence of adverse events than drug therapy. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Side Effects | Review |
| 35313481 | When combined with drugs to treat pain diseases, acupuncture can enhance the analgesic effect and reduce patients' dependence on drugs and even reduce the side effects of drugs. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Side Effects | Review |
| 24206922 | No adverse effect was found in acupuncture group, while in cisapride and mosapride group, some mild side effects such as dry mouth, dizziness, diarrhea, debilitation, erythra were observed. | BMC Complement Altern Med. 2013 Nov 9;13:311. doi: 10.1186/1472-6882-13-311. | Side Effects Adverse Reactions | Review |
| 24278807 | Scalp acupuncture is more easily accessible, less expensive, entails less risk, can yield quicker responses, and causes fewer side effects than many Western treatments. | Glob Adv Health Med. 2012 Mar;1(1):102-21. doi: 10.7453/gahmj.2012.1.1.017. | Side Effects | Review |
| 24278807 | Scalp acupuncture for MS is accessible, less expensive, safer, more effective, and causes fewer side effects than Western medical treatments. | Glob Adv Health Med. 2012 Mar;1(1):102-21. doi: 10.7453/gahmj.2012.1.1.017. | Side Effects | Review |
| 24322588 | Additional studies suggest that electroacupuncture, when combined with low dosages of conventional analgesics, provides effective pain management that can forestall the side effects of often-debilitating pharmaceuticals. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Side Effects | Review |
| 24322588 | These studies show that electroacupuncture treatment has the potential to allow the use of lower dosages of such medications in clinical settings, thus reducing side effects and improving patient quality of life. | Anesthesiology. 2014 Feb;120(2):482-503. doi: 10.1097/ALN.0000000000000101. | Side Effects | Review |
| 24349293 | This study is carried out to evaluate the efficacy of different type of acupuncture, acupoint selection, optimal timing, technique of intervention, side effects and used of rescue therapy in PONV in the recent years. | PLoS One. 2013 Dec 13;8(12):e82474. doi: 10.1371/journal.pone.0082474. eCollection 2013. | Side Effects | Review |
| 24349293 | Use of electro-acupuncture also resulted in a decrease in the incidence of opioid-related side effects after lower abdominal surgery. | PLoS One. 2013 Dec 13;8(12):e82474. doi: 10.1371/journal.pone.0082474. eCollection 2013. | Side Effects | Review |
| 24407111 | The acupuncture modality is relatively convenient and cost-efficient with few side-effects. | Prog Neurobiol. 2014 Apr;115:246-69. doi: 10.1016/j.pneurobio.2013.12.007. Epub 2014 Jan 7. | Side Effects | Review |
| 24566146 | Other research showed that acupuncture can inhibit the nigrostriatal neurodegeneration caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication by increasing expression levels of tyrosine hydroxylase (TH) and dopamine transporter (DAT). | Int J Mol Sci. 2014 Feb 21;15(2):3234-52. doi: 10.3390/ijms15023234. | Toxic Side Effects | Review |
| 24701237 | In clinic, acupuncture therapy for EM is confirmed to improve efficacy with fewer side effects, especially in EM-associated dysmenorrhoea. | Evid Based Complement Alternat Med. 2014;2014:146383. doi: 10.1155/2014/146383. Epub 2014 Feb 19. | Side Effects | Review |
| 24716180 | The most current Cochrane review on acupuncture for migraine prophylaxis concluded in 2009 that acupuncture is at least as effective as the standard drug treatment for migraine and carries fewer side effects. | J Tradit Complement Med. 2013 Oct;3(4):213-20. doi: 10.4103/2225-4110.119720. | Side Effects | Review |
| 24716183 | Acupuncture (a complementary modality) plays some role in reducing the hot flashes in breast cancer patients on treatment with accompanying side effects. | J Tradit Complement Med. 2013 Oct;3(4):234-9. doi: 10.4103/2225-4110.119733. | Side Effects | Review |
| 24744814 | Low level laser therapy (LLLT) on wound areas as well as on acupuncture points, as a noninvasive, pain-free method with minor side effects, has been considered as a possible treatment option for the diabetic foot syndrome. | Evid Based Complement Alternat Med. 2014;2014:626127. doi: 10.1155/2014/626127. Epub 2014 Mar 16. | Side Effects | Review |
| 25032003 | It is generally accepted that acupuncture is safe and not associated with serious side effects. | J Adv Pract Oncol. 2013 Jul;4(4):219-31. doi: 10.6004/jadpro.2013.4.4.3. | Side Effects | Review |
| 25032003 | Xerostomia is a difficult radiation-induced side effect to treat, and acupuncture has shown benefit for treatment of this condition. | J Adv Pract Oncol. 2013 Jul;4(4):219-31. doi: 10.6004/jadpro.2013.4.4.3. | Side Effects | Review |
| 25132858 | Meanwhile WAA was associated with fewer side effects as compared with western medicine and equal safety to sham acupuncture. | Evid Based Complement Alternat Med. 2014;2014:261709. doi: 10.1155/2014/261709. Epub 2014 Jul 15. | Side Effects | Review |
| 25254059 | Patients benefit from the lack of side effects and relatively low cost involved in acupuncture. | Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. | Side Effects | Review |
| 25254059 | (c) Side effect acupuncture versus sham acupuncture. | Evid Based Complement Alternat Med. 2014;2014:850367. doi: 10.1155/2014/850367. Epub 2014 Sep 2. | Side Effects | Review |
| 25379462 | The application and use of Acupuncture (éç¸ ZhÄn JiÇ) comes with some side effects. | J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. | Side Effects | Review |
| 25379462 | Like other strategies used in treating health conditions, acupuncture (éç¸ ZhÄn JiÇ) may have some side effects. | J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. | Side Effects | Review |
| 25379462 | This was further strengthened by the fact that the side effects of acupuncture (éç¸ ZhÄn JiÇ) are much less than that of conventional drugs that are being sold by pharmaceutical companies. | J Tradit Complement Med. 2014 Oct;4(4):218-23. doi: 10.4103/2225-4110.139113. | Side Effects | Review |
| 25383081 | Acupuncture may represent a potentially valuable adjunctive strategy for pain alleviation, and it is known to be relatively free of harmful side effects. | Evid Based Complement Alternat Med. 2014;2014:191347. doi: 10.1155/2014/191347. Epub 2014 Oct 14. | Side Effects | Review |
| 25892995 | Compared to anti-obesity drugs (Orlistat and Sibutramine), moreover, acupuncture displayed equally positive results, with a reduced number of side effects and relapses. | Int J Endocrinol Metab. 2015 Apr 20;13(2):e19678. doi: 10.5812/ijem.19678. eCollection 2015 Apr. | Side Effects | Review |
| 25892995 | Putting together larger, more carefully designed clinical trials, with long duration of follow up and strict protocols, for registering side effects and adverse events, is mandatory to offer proof of the value of herbal supplements, acupuncture and non-invasive body contouring in overweight/obese individuals. | Int J Endocrinol Metab. 2015 Apr 20;13(2):e19678. doi: 10.5812/ijem.19678. eCollection 2015 Apr. | Side Effects | Review |
| 26161404 | This review article provides an overview of published data regarding the potential toxic effects of different anesthetic techniques (Loco-regional, general anesthesia (GA), and monitored anesthesia care (MAC)), different anesthetic agents, and alternative medicine approach (principally acupuncture) on the IVF outcome. | Biomed Res Int. 2015;2015:475362. doi: 10.1155/2015/475362. Epub 2015 Jun 16. | Toxic Side Effects | Review |
| 26161404 | Specifically, we included studies using either traditional anesthetic procedures or alternative medicine (acupuncture) for pain relief during ART and only trials that assessed IVF outcomes in terms of different parameters such us pregnancy rate, fertilization rate, number and quality of oocytes collected, embryo quality, and follicular levels of an anesthetic agent possibly related to toxicity. | Biomed Res Int. 2015;2015:475362. doi: 10.1155/2015/475362. Epub 2015 Jun 16. | Pain Relief Toxic Side Effects | Review |
| 26355256 | However, acupuncture has virtually no lasting side effects and therefore could be offered very reasonably as an alternative therapy to interested patients with UP who do not respond to first-line treatments, who are unwilling to take systemic medications, or who have a particular interest in acupuncture. | Semin Nephrol. 2015 Jul;35(4):383-91. doi: 10.1016/j.semnephrol.2015.06.009. | Side Effects | Review |
| 26522652 | There were no side effects for participants receiving acupuncture; electroacupuncture; acupressure; or transcutaneous electro-acupoint stimulation. | Cochrane Database Syst Rev. 2015 Nov 2;2015(11):CD003281. doi: 10.1002/14651858.CD003281.pub4. | Side Effects | Review |
| 26652982 | Another single-arm study by Garcia et al demonstrated that electroacupuncture was safe and possibly effective in treating thalidomide/bortezomib-induced peripheral neuropathy in 19 multiple myeloma patients with significant improvements in Functional Assessment of Cancer therapy-neurotoxicity score after 9 weeks treatment. | Crit Rev Oncol Hematol. 2016 Feb;98:325-34. doi: 10.1016/j.critrevonc.2015.11.014. Epub 2015 Nov 23. | Toxic Side Effects | Review |
| 26945382 | However, only 2 RCTs reported acupuncture induced side effects, including dizziness during needle insertion (5/30), subcutaneous bleeding (3/30), and mild burn, which was observed in few cases when moxibustion was inappropriately conducted, which was judged by the original RCT. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Side Effects Bleeding | Review |
| 26945382 | Overall, acupuncture and related therapies only caused minor side effects. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Side Effects | Review |
| 26945382 | Results from our SR suggested clinicians may consider acupuncture and related therapies for cancer related pain, in particular when pain control is unsatisfactory under conventional care, or when patients are experiencing significant side effects induced by analgesic medications. | Medicine (Baltimore). 2016 Mar;95(9):e2901. doi: 10.1097/MD.0000000000002901. | Side Effects | Review |
| 27358589 | The use of acupuncture in these patients has been recommended by the American Cancer Society (ACS) for the treatment of side effects associated with conventional cancer therapy and cancer-related ailments. | Contemp Oncol (Pozn). 2016;20(2):119-23. doi: 10.5114/wo.2016.60065. Epub 2016 Jun 14. | Side Effects | Review |
| 27358589 | Acupuncture, belonging to the Manipulative Therapies category, due to its low cost, safety (considering all possible contraindications) and the minimal number of side effects is gaining popularity among patients. | Contemp Oncol (Pozn). 2016;20(2):119-23. doi: 10.5114/wo.2016.60065. Epub 2016 Jun 14. | Side Effects | Review |
| 27358589 | Acupuncture has repeatedly been reported to be useful in oncological practice in alleviating side effects of anti-tumor treatment. | Contemp Oncol (Pozn). 2016;20(2):119-23. doi: 10.5114/wo.2016.60065. Epub 2016 Jun 14. | Side Effects | Review |
| 27358589 | Despite many RCTs on treatment of other chemotherapy-induced side effects, the level of evidence is not yet satisfactory, but considering its relative safety, acupuncture may be useful in everyday practice. | Contemp Oncol (Pozn). 2016;20(2):119-23. doi: 10.5114/wo.2016.60065. Epub 2016 Jun 14. | Side Effects | Review |
| 27358589 | Descriptions of these clinical trials on the effectiveness of acupuncture in minimizing cancer treatment-related side effects are summarized in Table 2. | Contemp Oncol (Pozn). 2016;20(2):119-23. doi: 10.5114/wo.2016.60065. Epub 2016 Jun 14. | Side Effects | Review |
| 27403201 | Acupuncture is a practical and cost-effective intervention with few adverse side effects that is useful for the treatment of many disorders. | Evid Based Complement Alternat Med. 2016;2016:9874207. doi: 10.1155/2016/9874207. Epub 2016 Jun 14. | Side Effects | Review |
| 27471137 | The incidences of side effects and adverse events with acupuncture are lower than that with opioid analgesics and anti-inflammatory medications. | Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. | Side Effects | Review |
| 27471137 | One possibility is that the treatment effects were blunted in the real acupuncture group because of the higher rates of side effects, particularly mild pain during treatment. | Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. | Side Effects | Review |
| 27471137 | Most side effects of acupuncture undergo spontaneous remission over several minutes or hours. | Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. | Side Effects | Review |
| 27471137 | The total occurrence rate for meaningful minor side effects, including pain at acupuncture points, nausea and vomiting, and dizziness or syncope, was less than 0.1%. | Sci Rep. 2016 Jul 29;6:30675. doi: 10.1038/srep30675. | Side Effects Nausea and Vomiting | Review |
| 27531549 | Acupuncture may help treat specific cancer-related symptoms, including pain, gastrointestinal side effects, hot flushes, fatigue, anxiety, and depression. | Integr Cancer Ther. 2017 Jun;16(2):135-146. doi: 10.1177/1534735416664172. Epub 2016 Aug 16. | Side Effects Anxiety Depression | Review |
| 27543143 | As a kind of economical and side-effect free natural remedies, acupuncture has been used in China widely for over 2000Â years. | BMC Complement Altern Med. 2016 Aug 19;16(1):297. doi: 10.1186/s12906-016-1298-3. | Side Effects | Review |
| 27705610 | The potential side effects of acupuncture in the context of TBI treatment and rehabilitation remain unclear and understudied. | Nutr Neurosci. 2018 Feb;21(2):79-91. doi: 10.1080/1028415X.2016.1236174. Epub 2016 Oct 5. | Side Effects | Review |
| 28664077 | Acupuncture stimulation has an acupoint-specific property that may be useful as a therapeutic alternative with few side effects for treating addiction to drugs such as nicotine, cocaine, and morphine. | Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. | Side Effects | Review |
| 28664077 | These authors also found that bee venom acupuncture at the GB34 point protected DA neurons effectively against MPTP toxicity, possibly by inhibition of phospho-Jun activation. | Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. | Toxic Side Effects | Review |
| 28664077 | Diluted bee venom acupuncture enhanced clonidine-induced analgesia significantly in both the mouse formalin test and the rat chronic constriction injury neuropathic pain model, suggesting that a combination of low-dose clonidine and acupuncture therapy decreases the side effects of clonidine. | Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. | Neuropathic Pain Side Effects | Review |
| 28664077 | These findings indicate that pairing a lower dose of a α2-adrenoceptor agonist such as clonidine with acupuncture stimulation may be an improved strategy for pain management, by enhancing analgesia and decreasing α2-adrenoceptor agonist-induced side effects. | Integr Med Res. 2014 Jun;3(2):41-48. doi: 10.1016/j.imr.2014.03.003. Epub 2014 Apr 1. | Side Effects | Review |
| 28740905 | Use of acupuncture to alleviate side effects in radiation oncology: Current evidence and future directions | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | Most of these studies discuss a benefit of acupuncture for side-effect reduction; however, not all could demonstrate significant improvements. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | Thus, innovative trial designs are necessary to confirm that acupuncture can alleviate side effects related to radiation therapy. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | Only articles fulfilling the following requirements were included in this review: (1) patients treated with RT, (2) acupuncture implemented to alleviate symptoms or side effects from RT, and (3) randomized prospective trial. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | Thus, the team from Fudan University could demonstrate that acupuncture works as an excellent strategy to alleviate side effects. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | The present article summarizes all relevant studies available on the effect of acupuncture to reduce radiation-related side effects. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | The primary aim of all trials was to demonstrate that verum acupuncture has the potential to reduce common side effects, including fatigue or xerostomia, in patients treated with radiation therapy. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | White et al published a cumulative review on acupuncture-related side effects and reported serious side effects at 0.05 per 10,000 patients treated. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | A conclusion from all studies, independent of RT treatment, is that acupuncture is considered a safe treatment without any severe side effects. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | Acupuncture has the potential to reduce side effects and enhance QoL when applied by an experienced therapist and in conjunction with high-end modern medicine. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | At the Technical University of Munich, Department of Radiation Oncology, we are currently in the process of implementing such trials, and the first study evaluating the effect of acupuncture on fatigue and QoL related to RT based on a sham acupuncture comparator is the first in line (Randomized double-blind study to evaluate the efficacy of acupuncture compared to sham-acupuncture to ameliorate radiation-related side effects [ROSETTA] Trial). | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28740905 | A few small studies have assessed the benefit of acupuncture against radiation-related side effects. | Adv Radiat Oncol. 2016 Aug 18;1(4):344-350. doi: 10.1016/j.adro.2016.08.002. eCollection 2016 Oct-Dec. | Side Effects | Review |
| 28851961 | We expected that acupuncture may have not less effect than anti-depressants on depression and have an advantage on less side effects, which is helpful for patients to adhere to the treatment. | Sci Rep. 2017 Aug 29;7(1):9669. doi: 10.1038/s41598-017-09712-1. | Side Effects Depression | Review |
| 28930208 | Complementary and alternative medical treatments like acupuncture, moxibustion, and massage are becoming more and more attractive because of their effectiveness, fewer side effects, and reliable safety. | Medicines (Basel). 2015 Aug 4;2(3):212-219. doi: 10.3390/medicines2030212. | Side Effects | Review |
| 28930208 | Acupuncture, moxibustion and massage are complementary alternative medicine techniques with reliable efficacy and fewer side effects, and are quickly becoming more widely used world-wide. | Medicines (Basel). 2015 Aug 4;2(3):212-219. doi: 10.3390/medicines2030212. | Side Effects | Review |
| 28930208 | Additionally, acupuncture was overall safer and produced fewer side effects than domperidone treatment. | Medicines (Basel). 2015 Aug 4;2(3):212-219. doi: 10.3390/medicines2030212. | Side Effects | Review |
| 28930208 | Acupuncture-treated patients reported no adverse reactions, whereas drug-treated patients did report adverse side-effects in two trials. | Medicines (Basel). 2015 Aug 4;2(3):212-219. doi: 10.3390/medicines2030212. | Side Effects Adverse Reactions | Review |
| 28930222 | Methods: The aims of the paper are to review the main and recent papers of international literature on the effectiveness of complementary medicine (CM) therapies on side effects of anti-cancer protocols and improvement in the quality of life of oncological patients, and to describe the integration of evidence-based acupuncture, herbal medicine and homeopathy treatments in Public Cancer Network of the region of Tuscany. | Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. | Side Effects | Review |
| 28930222 | Results: After the review of literature and the approval of a Regional Resolution, some CM will be introduced in Cancer Departments in Tuscany to additionally treat cancer-related symptoms and side effects of conventional cancer therapy: acupuncture for nausea and post-chemotherapy and post-surgery vomiting, pain, hot flashes of iatrogenic menopause, xerostomia; homeopathy for hot flashes of iatrogenic menopause and the side effects of radiotherapy; herbal medicine for cancer-related fatigue, nausea and vomiting, pain, mucositis, anxiety, and depression. | Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. | Side Effects Nausea and Vomiting Anxiety Depression | Review |
| 28930222 | These show promising positive effects for depressive symptoms, but the methodological problems (no randomization for some, low number of participants, undefined protocol according to the Stricta criteria) make it necessary to perform well-designed studies to demonstrate the effectiveness of acupuncture which, however, remains a treatment with fewer side effects than pharmacological therapies. | Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. | Side Effects | Review |
| 28930222 | It is worth remembering that, unlike acupuncture and homeopathy, which have very few side effects or interactions, the use of medicinal plants in oncology requires attention and specific high standard skills. | Medicines (Basel). 2017 Jan 24;4(1):5. doi: 10.3390/medicines4010005. | Side Effects | Review |
| 29143805 | Manual acupuncture at Zusanli (ST36) and EA at Baihui (GV20) improves cognitive hippocampus function by modulating cAMP/PKA/CREB and by reducing the expression of NR1-TRPV1, thus reducing deficits related to LTP due to excitotoxicity. | Int J Mol Sci. 2017 Oct 28;18(11):2270. doi: 10.3390/ijms18112270. | Toxic Side Effects | Review |
| 29229658 | Clinical studies have shown benefits of acupuncture and related therapies for supportive and palliative care in cancer, by diminishing side effects of conventional therapies, relieving cancer-related concomitant symptoms and improving overall quality of life. | BMJ Open. 2017 Dec 10;7(12):e018494. doi: 10.1136/bmjopen-2017-018494. | Side Effects | Review |
| 29234418 | Acupuncture is a useful form of complementary/alternative medicine for the managing neurodegenerative disorders, because it can reduce the side effects of therapy as well as the financial burden of treatment on patients and their families. | Evid Based Complement Alternat Med. 2017;2017:6512520. doi: 10.1155/2017/6512520. Epub 2017 Sep 27. | Side Effects | Review |
| 29722298 | Electroacupuncture pretreatment or treatment after ischemic stroke by using appropriate electroacupuncture parameters generates neuroprotective and neuroregenerative effects that increase cerebral blood flow, regulate oxidative stress, attenuate glutamate excitotoxicity, maintain blood-brain barrier integrity, inhibit apoptosis, increase growth factor production, and induce cerebral ischemic tolerance. | Neural Regen Res. 2018 Apr;13(4):573-583. doi: 10.4103/1673-5374.230272. | Neuroprotection Toxic Side Effects Blood Flow | Review |
| 29722298 | Acupuncture, one of the most important components of traditional Chinese medicine, has been shown to activate relevant brain regions, modulate cerebral blood flow (CBF), and regulate multiple molecules and signaling pathways that lead to excitotoxicity, oxidative stress, inflammation, neuronal death, and survival after interruption of blood supply. | Neural Regen Res. 2018 Apr;13(4):573-583. doi: 10.4103/1673-5374.230272. | Toxic Side Effects Blood Flow | Review |
| 29722298 | Acupuncture intervention can significantly reduce the size of the infarcted area, improve cerebral blood circulation to promote regional energy metabolism, regulate blood lipid metabolism to resist cerebral free radical damage, inhibit cerebral cortical apoptosis, reduce the amount of excitatory amino acids to lower neurogenic toxicity, reduce calcium overloading, ease cerebral vascular immune-inflammatory reactions, and upregulate the expression of antiapoptosis genes and neurotrophic factors, thereby promoting the proliferation and differentiation of neural stem cells in the focal cerebral cortex and hippocampus. | Neural Regen Res. 2018 Apr;13(4):573-583. doi: 10.4103/1673-5374.230272. | Immunity Toxic Side Effects Circulation | Review |
| 29729027 | Two RCTs reported minor side effects of acupuncture, which were primarily minor bruising, bleeding, or pain at needle insertion sites. | Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. | Side Effects Bleeding | Review |
| 29729027 | Possible side effects associated with acupuncture treatment were minor. | Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. | Side Effects | Review |
| 29729027 | Possible side effects of acupuncture treatment included minor bruising and bleeding at the site of needle insertion, which were reported in 2 trials. | Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. | Side Effects Bleeding | Review |
| 29729027 | Additionally, a large UK survey of patients who received acupuncture treatment supports the notion that serious adverse effects of acupuncture are very rare, while minor side effects such as pain, nausea, or bruising at the site of needling may be experienced by up to 30% of patients. | Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. | Side Effects Adverse Reactions Nausea and Vomiting | Review |
| 29729027 | Additionally, some patients experience the minor side effects of bruising and bleeding at needle insertion points, and thus acupuncture should be used cautiously by patients on anticoagulant therapy, or by patients who have a bleeding disorder. | Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. | Side Effects Bleeding | Review |
| 29729027 | Two RCTs reported minor side effects of acupuncture, which were primarily minor bruising, bleeding, or pain at needle insertion sites. | Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010. | Side Effects Bleeding | Review |
| 29941854 | Integration of acupuncture treatments with conventional therapies, and pharmacological agents should lead to medical strategies without addictive side effects. | Medicines (Basel). 2018 Jun 25;5(3):63. doi: 10.3390/medicines5030063. | Side Effects | Review |
| 30117343 | Acupuncture can help reduce unpleasant side effects associated with endocrine therapy for breast cancer. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Endocrinology Side Effects | Review |
| 30117343 | To estimate the efficacy of acupuncture for the reduction of hormone therapy-related side effects in breast cancer patients. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Side Effects | Review |
| 30117343 | An increasing number of studies indicate that acupuncture can be used in treatment-related symptom control and the alleviation of side effects caused by hormone treatment. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Side Effects | Review |
| 30117343 | The aim of this meta-analysis, therefore, was to assess the efficacy of acupuncture for treatment-related side effects of hormone therapy and the quality of life of patients with breast cancer. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Side Effects | Review |
| 30117343 | A forest plot of the effects of the subgroup acupuncture therapies on treatment-related side effects: the width of the horizontal lines represent the 95% CIs of the individual studies, and the squares represent the proportional weight of each study. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Side Effects | Review |
| 30117343 | Residual confounding factors, including the characteristics of the acupuncture prescription, age at diagnosis, disease stage and severity, frequency, duration of the intervention for treatment-related side effects, indications for acupuncture, hormone prescription, lifestyle factors, and self-reported quality of life could not be completely excluded, and the findings thus could not result in a reasonable recommendation. | Integr Cancer Ther. 2018 Sep;17(3):602-618. doi: 10.1177/1534735418786801. | Side Effects | Review |
| 30298094 | Scalp acupuncture has been reported to (1) improve cerebral blood circulation, promoting regional energy metabolism; (2) upregulate expression of glial cell-line derived neurotrophic factor (GDNF), possibly promoting proliferation and differentiation of neural stem cells in the focal cerebral cortex and hippocampus; (3) reduce contents of excitatory amino acid and increase level of GABA, thus lowering neurogenic toxicity; (4) ease cerebral vascular immunoinflammatory reactions; (5) regulate blood lipid metabolism to resist cerebral free radical damage; and (6) inhibit cerebral cortical apoptosis. | Evid Based Complement Alternat Med. 2018 Sep 12;2018:8107508. doi: 10.1155/2018/8107508. eCollection 2018. | Immunity Toxic Side Effects Circulation | Review |
| 30365567 | No serious side effects occurred when using acupuncture on these four lifestyle risk factors. | PLoS One. 2018 Oct 26;13(10):e0206288. doi: 10.1371/journal.pone.0206288. eCollection 2018. | Side Effects | Review |
| 30416533 | Other studies have reported that electroacupuncture suppressed the relapse rate and plasma β-endorphin and dynorphin A levels in heroin addicts and the prolonged acupuncture treatment showed dominant control effects on heroin craving behaviors with little side effects. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Side Effects | Review |
| 30424749 | Acupuncture, an economical type of traditional Chinese therapy with minimal side effects, has been used for many diseases in Asian countries for thousands of years and is widely used for rehabilitation after stroke. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Side Effects | Review |
| 30584456 | Given the fact that 10-20% of females with PD do not respond to NSAIDs or oral contraceptives treatment or are just not suitable for its indications or intolerant to the side effects, alternative therapies have become an important supplement for PD treatment, among which acupuncture has played the leading role. | Evid Based Complement Alternat Med. 2018 Nov 21;2018:8791538. doi: 10.1155/2018/8791538. eCollection 2018. | Side Effects | Review |
| 30618558 | Shi shows that acupuncture may decrease the N-methyl-D-aspartate receptor subtype 1 (NMDAR1) mRNA mediated excitotoxicity of glutamate after cerebral ischemia-reperfusion injury (Shi,). | Front Neurosci. 2018 Dec 11;12:929. doi: 10.3389/fnins.2018.00929. eCollection 2018. | Toxic Side Effects | Review |
| 30762808 | With few side effects, acupuncture treatment for PDD has been gradually accepted. | Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. | Side Effects | Review |
| 30762808 | Compared with other treatments, acupuncture has the advantages of safety, convenience, fewer side effects, and significant efficacy. | Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. | Side Effects | Review |
| 30762808 | Although the mechanism of acupuncture as a non-drug therapy for the treatment of PDD is not yet clear, its curative effect has been proved, with few adverse reactions and almost no side effects. | Medicine (Baltimore). 2019 Feb;98(7):e14574. doi: 10.1097/MD.0000000000014574. | Side Effects Adverse Reactions | Review |
| 30809158 | After completing individualized acupuncture sessions, patients reported improvements in symptoms of schizophrenia, side effects of medication, energy, motivation, sleep, addictions and other associated physical problems. | Front Psychiatry. 2019 Feb 12;10:14. doi: 10.3389/fpsyt.2019.00014. eCollection 2019. | Side Effects | Review |
| 30854010 | After acupuncture treatment, the active component such as 5-Hydroxytryptamine (5-HT) and Histamine (HB) in the gastrointestinal microcirculation decreased in obese patients, while prostaglandin E2(PGE2) increased on the effected side. | Evid Based Complement Alternat Med. 2019 Feb 3;2019:5796381. doi: 10.1155/2019/5796381. eCollection 2019. | Microcirculation Side Effects | Review |
| 30915143 | A domestic study shows that after summing up clinical diseases and symptoms treated by modern acupuncture abroad, 110 diseases and symptoms were considered effective. | Evid Based Complement Alternat Med. 2019 Feb 24;2019:2326867. doi: 10.1155/2019/2326867. eCollection 2019. | Side Effects | Review |
| 30984420 | Acupuncture is able to lower BP, resulting in medication dosage reduction, medication types reduction, and fewer side effects, which is regarded as an adjunctive therapy for hypertension. | Int J Hypertens. 2019 Mar 7;2019:8676490. doi: 10.1155/2019/8676490. eCollection 2019. | Dosage of Medication Side Effects Blood Pressure | Review |
| 30984420 | Acupuncture as a nonpharmacological therapy has fewer side effects, in contrast to drug treatments. | Int J Hypertens. 2019 Mar 7;2019:8676490. doi: 10.1155/2019/8676490. eCollection 2019. | Side Effects | Review |
| 30984420 | In summary, acupuncture as a treatment for hypertension has many advantages, in terms of efficacy, sustained effects, fewer side effects, target organ protection, improvement in patient compliance, etc. | Int J Hypertens. 2019 Mar 7;2019:8676490. doi: 10.1155/2019/8676490. eCollection 2019. | Side Effects Organ Protection | Review |
| 31016194 | These findings indicate that although the efficacy of acupuncture was lower compared to antidepressants, the benefits of acupuncture were still attractive to women with postpartum depression due to their negligible side-effects. | Biomed Res Int. 2019 Mar 20;2019:6597503. doi: 10.1155/2019/6597503. eCollection 2019. | Side Effects Depression | Review |
| 31110553 | It is suggested in some meta-analyses that acupuncture or CHM alone can attain a more satisfactory clinical efficacy rate, greater improvement of specific symptoms (such as abdominal pain, diarrhea, and abdominal distension), while fewer obvious side effects than the control treatments. | Evid Based Complement Alternat Med. 2019 Apr 14;2019:7680963. doi: 10.1155/2019/7680963. eCollection 2019. | Side Effects | Review |
| 31110553 | Moreover, acupuncture combined with THM has displayed a synergistic effect on strengthening the curative effect, shortening the course of treatment, prolonging the duration of efficacy, and reducing side effects. | Evid Based Complement Alternat Med. 2019 Apr 14;2019:7680963. doi: 10.1155/2019/7680963. eCollection 2019. | Side Effects | Review |
| 31223326 | Three trials found that in the acupuncture- and Tai Chi-medication groups, the side effects caused by medication were significantly reduced. | Evid Based Complement Alternat Med. 2019 May 15;2019:2183403. doi: 10.1155/2019/2183403. eCollection 2019. | Side Effects | Review |
| 31379957 | In addition to medication and psychosocial support, acupuncture serves as an alternative option for patients with depression that exhibits promising effects and fewer side effects. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Side Effects Depression | Review |
| 31379957 | performed a microarray analysis study of acupuncture on GB34 and LR3 in an MPTP mouse model of parkinsonism and reported that acupuncture reversed the downregulation of five annotated genes and upregulation of three annotated genes through MPTP intoxication. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Toxic Side Effects | Review |
| 31379957 | Acupuncture modulates neuroinflammation by inactivating ERK 1/2 and p38/MAPK signaling pathway and reduces neuronal excitotoxicity through the pPKA/pPKC/CaMKIIα signaling pathway. | Evid Based Complement Alternat Med. 2019 Jul 11;2019:2909632. doi: 10.1155/2019/2909632. eCollection 2019. | Toxic Side Effects | Review |
| 31467579 | There are no reports demonstrating that electroacupuncture may have side effects during labor analgesia. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Side Effects | Review |
| 31467579 | Scholars from the Tianjin Medical University found that PKCa and p38MAPK pathways are involved in the electroacupuncture-mediated upregulation of HO-1 expression during acute lung injury in rabbits with endotoxic shock. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Toxic Side Effects | Review |
| 31467579 | The protective role of Keap 1-Nrf2/ARE pathway in electroacupuncture-relieved lung injury induced by endotoxic shock in rabbits is related to its phosphorylation, which promoted nuclear translocation of Nrf2 protein by p38MAPK. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Toxic Side Effects | Review |
| 31467579 | found that electroacupuncture can regulate the MAPK/ERK signaling pathway, reduce the expression of p-ERK in the early stage of cerebral ischemia, and finally interfere with the potential toxic effects on neurons thereby protecting the brain. | Evid Based Complement Alternat Med. 2019 Jul 31;2019:8138017. doi: 10.1155/2019/8138017. eCollection 2019. | Toxic Side Effects | Review |
| 31517844 | Acupoint therapies, including acupuncture, acupressure, acupoints injection, massage, and moxibustion, are safe medical procedures with minimal side effects for CINV, but studies about overall safety and effectiveness of acupoint therapies have not been scientifically and methodically evaluated in recent years. | Medicine (Baltimore). 2019 Sep;98(37):e17109. doi: 10.1097/MD.0000000000017109. | Side Effects | Review |
| 31517844 | Acupoint therapies include acupuncture, acupressure, acupoints injection, massage, and moxibustion, which are safe medical procedures with minimal side effects for CINV. | Medicine (Baltimore). 2019 Sep;98(37):e17109. doi: 10.1097/MD.0000000000017109. | Side Effects | Review |
| 31517846 | This study will provide high-quality synthesis based on current evidence of acupuncture treatment for COPD in several aspects, including symptom score, quality of life score, side effects and laboratory examination, such as lung function text, blood eosinophils (EOS) etc. | Medicine (Baltimore). 2019 Sep;98(37):e17112. doi: 10.1097/MD.0000000000017112. | Side Effects | Review |
| 31517846 | With few side effects, wide indication, convenient operation, economical, and safety, acupuncture has been used for thousands of years in China. | Medicine (Baltimore). 2019 Sep;98(37):e17112. doi: 10.1097/MD.0000000000017112. | Side Effects | Review |
| 31565065 | Acupuncture treatments are used frequently in the treatment of primary insomnia considering its less side effect. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Side Effects Insomnia | Review |
| 31565065 | In China, acupuncture is considered as an effective alternative treatment for insomnia because of its low side effects and easy availability. | Evid Based Complement Alternat Med. 2019 Sep 3;2019:8961748. doi: 10.1155/2019/8961748. eCollection 2019. | Side Effects Insomnia | Review |
| 31567462 | If opioid therapy creates undesirable effects, such as sedation, constipation, fatigue, nausea, and emesis, the addition of acupuncture has the potential of lowering the required dose of pain medications and hence their side effects. | Cancer J. 2019 Sep/Oct;25(5):343-348. doi: 10.1097/PPO.0000000000000399. | Side Effects Nausea and Vomiting Sedation | Review |
| 31680841 | A systematic review consisting of twenty-two trials with a total of 4,419 patients came to the conclusion that acupuncture is not only at least as effective for migraine prophylaxis as prophylactic drug treatment but that it also has less side effects. | Front Neurosci. 2019 Oct 17;13:1110. doi: 10.3389/fnins.2019.01110. eCollection 2019. | Side Effects | Review |
| 31702639 | Acupuncture may be one of the alternative methods to treat insomnia, with little side effects. | Medicine (Baltimore). 2019 Nov;98(45):e17842. doi: 10.1097/MD.0000000000017842. | Side Effects Insomnia | Review |
| 31772597 | As a physical therapy with low side effects, acupuncture is suitable for long-term application, but no studies have observed the survival curve of acupuncture in the treatment of HF. | Evid Based Complement Alternat Med. 2019 Oct 20;2019:6074967. doi: 10.1155/2019/6074967. eCollection 2019. | Side Effects | Review |
| 31814859 | 11 studies included referred the side effects information of treatments, among which 2 studies reported a bit obvious side effects about acupuncture: 1 study recording the absorbable congestion around eyes after removing needles, the other study recorded one case of needle fainting which was shortly relieved by warm water. | Pain Res Manag. 2019 Nov 11;2019:2871505. doi: 10.1155/2019/2871505. eCollection 2019. | Side Effects | Review |
| 31914030 | With the increasing side effects of drug use and drug resistance, acupuncture is becoming more and more popular. | Medicine (Baltimore). 2020 Jan;99(2):e18548. doi: 10.1097/MD.0000000000018548. | Side Effects | Review |
| 32080154 | Of the included studies, only 3 RCTs reported adverse events, and there were no side effects associated with ear acupuncture. | Medicine (Baltimore). 2020 Feb;99(8):e19342. doi: 10.1097/MD.0000000000019342. | Side Effects | Review |
| 32148660 | Since acupuncture is nonpharmacologically based, there are no concerns regarding dependence, addiction, tolerance, and neurological toxicity, nor will acupuncture increase the metabolic burdens of the liver and kidney, making acupuncture a potentially attractive therapy for treating POCD. | Oxid Med Cell Longev. 2020 Feb 13;2020:9641904. doi: 10.1155/2020/9641904. eCollection 2020. | Toxic Side Effects Kidney | Review |
| 32195928 | In addition, compared to pharmacological agents, acupuncture has the advantages of cheap, safe, reliable, and easy to use without side effects. | Medicine (Baltimore). 2020 Mar;99(12):e18969. doi: 10.1097/MD.0000000000018969. | Side Effects | Review |
| 32318130 | Acupuncture was also found to lower the incidences of side effects compared with analgesics. | Pain Res Manag. 2020 Mar 20;2020:8506591. doi: 10.1155/2020/8506591. eCollection 2020. | Side Effects | Review |
| 32318130 | Additionally, the side effects or complications of acupuncture were reported so insufficiently that other meaningful clinical endpoints could not be evaluated. | Pain Res Manag. 2020 Mar 20;2020:8506591. doi: 10.1155/2020/8506591. eCollection 2020. | Side Effects | Review |
| 32337259 | Acupuncture is an integral part of traditional Chinese medicine with considerable clinical efficacy and minimal side effects that can be traced back for at least 4000 years. | Biomed Res Int. 2020 Mar 31;2020:5901573. doi: 10.1155/2020/5901573. eCollection 2020. | Side Effects | Review |
| 32630156 | The effectiveness of acupuncture was similar to or greater than that of prophylactic pharmacotherapy, with fewer side effects in migraine. | Int J Mol Sci. 2020 Jun 30;21(13):4693. doi: 10.3390/ijms21134693. | Side Effects | Review |
| 32630156 | Further studies are required to identify and characterize the various substrates of these kinases involved in cell differentiation/cell repair, neurotoxicity, and neurodegeneration, thus potentially furthering the current understanding of the mechanism underlying acupuncture in treating these diseases. | Int J Mol Sci. 2020 Jun 30;21(13):4693. doi: 10.3390/ijms21134693. | Toxic Side Effects | Review |
| 32714268 | Compared with medication, acupuncture therapy is relatively low-cost and has fewer side effects, making it an attractive option for the auxiliary regulation and prevention of various chronic diseases. | Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. | Side Effects | Review |
| 32714268 | This was demonstrated through the lower frequency of migraine attacks, lower VAS score, and fewer side effects observed in the acupuncture group (compared to the sham acupuncture group). | Front Neurol. 2020 Jun 30;11:596. doi: 10.3389/fneur.2020.00596. eCollection 2020. | Side Effects | Review |
| 32714417 | In the treatment of chronic pain with depression, acupuncture could not only get better clinical efficacy, but also have higher security compared with medicine therapy, which can be used in patients with poorer response to the conventional medication or suffering from serious side effects. | Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. | Side Effects Depression | Review |
| 32714417 | Acupuncture uses needles to stimulate specified acupuncture points, which has the advantages of simple operation, economical cost and few side effects, and it has obvious curative effect on pain and depression separately. | Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. | Side Effects Depression | Review |
| 32714417 | Patients in the experimental group had lower incidence of adverse events and side effect scores, which proved the safety of acupuncture. | Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. | Side Effects | Review |
| 32714417 | The results of the systematic review suggested that acupuncture has a promising application prospect due to its unique advantages for the treatment of chronic pain with depression, and it can be used in patients with poorer response to the medication or suffering from serious side effects. | Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. | Side Effects Depression | Review |
| 32714417 | Acupuncture has a promising application prospect due to its unique advantages for the treatment of chronic pain with depression comorbidity, which can be used in patients suffering from some certain chronic pain with depression comorbidity with poorer response to the conventional medication or suffering from serious side effects. | Evid Based Complement Alternat Med. 2020 Jun 25;2020:7479459. doi: 10.1155/2020/7479459. eCollection 2020. | Side Effects Depression | Review |
| 32718258 | Methods: Randomized controlled trials of acupuncture versus a control or placebo in breast cancer patients that examined reductions in therapy-related side effects were retrieved from PubMed, EMBASE, Web of Science, and the Cochrane Library through April 2020. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Side Effects | Review |
| 32718258 | Previous studies have suggested that a substantial proportion of patients with breast cancer use acupuncture and that acupuncture may relieve cancer treatment-related side effects. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Side Effects | Review |
| 32718258 | The present study included a comprehensive and reproducible search of the literature examining the effect of acupuncture on the management of the postoperative side effects of breast cancer, as well as a transparent study selection process. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Side Effects | Review |
| 32718258 | There were some concerns around serious methodological defects found in the retrieved original RCTs of acupuncture for therapy-related side effects management with breast cancer patients in the regional language database. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420940394. doi: 10.1177/1534735420940394. | Side Effects | Review |
| 32875921 | The inclusion criteria were as follows: (1) SRs and meta/analyses of clinical studies in which at least 1 RCT was included; (2) target population was any type of cancer participants with CIPN (any type of chemotherapy) where the nonpharmacological management was the primary focus of the review; (3) the interventions included were nonpharmacological approaches such as lifestyle interventions, physical therapy, nutritional supplements, and complementary medicine therapies (eg, acupuncture, herbal medicine); (4) comparator(s)/control were pharmacological control or any other forms of control (eg, placebo, no intervention); and (5) the main outcomes reported were neurotoxicity incidence and/or severity measured by standardized and validated clinical assessment tools, including, but not limited to, patient-reported outcomes, clinician-rated neuropathy assessments, and physical/functional measures. | Integr Cancer Ther. 2020 Jan-Dec;19:1534735420945027. doi: 10.1177/1534735420945027. | Toxic Side Effects | Review |
| 32992601 | Despite its clinical complications, toxicity or anaphylaxis, it is a safe form of acupuncture and it has interesting pharmacological properties from a biotechnological point of view. | Toxins (Basel). 2020 Sep 27;12(10):618. doi: 10.3390/toxins12100618. | Toxic Side Effects | Review |
| 33441387 | In the past decade, acupuncture has been actively used for relieving cancer pain, as well as decreasing analgesic medication doses and side effects. | BMJ Support Palliat Care. 2021 Sep;11(3):264-270. doi: 10.1136/bmjspcare-2020-002638. Epub 2021 Jan 13. | Dosage of Medication Cancer Pain Side Effects | Review |
| 33441387 | The impact of acupuncture on cancer pain in palliative care was sparsely addressed in reviews of acupuncture on pain improvement, though reviews have included other symptoms such as fatigue, nausea, depression, chemotherapy-induced or radiotherapy-induced side effects for palliative care in patients with cancer. | BMJ Support Palliat Care. 2021 Sep;11(3):264-270. doi: 10.1136/bmjspcare-2020-002638. Epub 2021 Jan 13. | Cancer Pain Side Effects Nausea and Vomiting Depression | Review |
| 33498883 | Regarding the risks or adverse effects of CTs in cancer patients, the RCTs on electroacupuncture, laser moxibustion and traditional Chinese medicine described side effects, although they are listed as mild and rapidly resolving symptoms. | Int J Environ Res Public Health. 2021 Jan 24;18(3):1017. doi: 10.3390/ijerph18031017. | Side Effects Adverse Reactions | Review |
| 33505460 | In addition to directly attenuating the deposition, neuroinflammatory response, and neurotoxicity of Aβ and increasing cerebral blood flow, acupuncture also could improve cognitive abilities through regulation of neuroplasticity (Figure 3). | Neural Plast. 2021 Jan 12;2021:8868447. doi: 10.1155/2021/8868447. eCollection 2021. | Toxic Side Effects Blood Flow | Review |
| 33586504 | Considering these unfavorable side effects, alternative approaches, such as acupuncture, yoga or exercise, have been used to treat AIA in recent years. | Integr Cancer Ther. 2021 Jan-Dec;20:1534735420980811. doi: 10.1177/1534735420980811. | Side Effects | Review |
| 33586504 | The Clinical Practice Guidelines also recommended that acupuncture is used to relieve side effects caused by conventional treatments for breast cancer. | Integr Cancer Ther. 2021 Jan-Dec;20:1534735420980811. doi: 10.1177/1534735420980811. | Side Effects | Review |
| 33586504 | No significant side effects were associated with acupuncture treatment. | Integr Cancer Ther. 2021 Jan-Dec;20:1534735420980811. doi: 10.1177/1534735420980811. | Side Effects | Review |
| 33868443 | Acupuncture therapy, as an important part of traditional Chinese medicine, has the characteristics of quick effects, low recurrence rates, and few side effects, an especially important value in pain control. | Evid Based Complement Alternat Med. 2021 Apr 2;2021:6694936. doi: 10.1155/2021/6694936. eCollection 2021. | Side Effects | Review |
| 33883931 | Patients receiving acupuncture therapy obtained improved symptoms in pain, neurotoxicity and distress which suggested that acupuncture could be a promising intervention in the treatment of CIPN. | J Pain Res. 2021 Apr 15;14:993-1005. doi: 10.2147/JPR.S296150. eCollection 2021. | Toxic Side Effects | Review |
| 33936242 | In recent years, acupuncture and moxibustion therapy has been widely used in the clinical treatment of various gynecological diseases due to its good clinical efficacy and few side effects. | Evid Based Complement Alternat Med. 2021 Apr 15;2021:6677767. doi: 10.1155/2021/6677767. eCollection 2021. | Side Effects | Review |
| 33986818 | ); (2) when acupuncture is used as an adjuvant therapy to standard Western pharmacotherapy, could it further enhance the therapeutic effect or reduce the side effects of the standard Western pharmacotherapy? | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Side Effects | Review |
| 33986818 | No studies reported if acupuncture could reduce the side effects of HRT or hypnotic drugs. | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Side Effects | Review |
| 33986818 | While three RCTs in this category showed the combined therapy was more significantly effective in improving PMI than hypnotics, none reported if acupuncture also reduces the side effects of those medications. | Evid Based Complement Alternat Med. 2021 Apr 26;2021:5566742. doi: 10.1155/2021/5566742. eCollection 2021. | Side Effects | Review |
| 34055020 | In recent years, due to the limited efficacy and common side effects of Western medicine in the process of treating PCOS patients, acupuncture plays an important role in the treatment of menstrual disorders caused by PCOS. | Evid Based Complement Alternat Med. 2021 May 17;2021:6678398. doi: 10.1155/2021/6678398. eCollection 2021. | Side Effects | Review |
| 34055020 | Nevertheless, the advantages of the abdominal acupuncture are more outstanding apparently, which reflected in less side effects, reducing BMI significantly by reducing visceral adipose tissue. | Evid Based Complement Alternat Med. 2021 May 17;2021:6678398. doi: 10.1155/2021/6678398. eCollection 2021. | Side Effects | Review |
| 34060024 | Traditional Chinese herbs and acupuncture have shown good anti-stress efficacy and fewer side effects in clinical application, which may improve the CSR in the battlefield. | Chin J Integr Med. 2021 Nov;27(11):874-880. doi: 10.1007/s11655-021-2864-1. Epub 2021 May 31. | Side Effects | Review |
| 34093119 | Acupuncture is one non-pharmacological therapy that has relatively few side effects, and is widely used for managing migraine, especially for drug-refractory patients (Xu et al.,; Chen et al.,). | Front Neurosci. 2021 May 20;15:674852. doi: 10.3389/fnins.2021.674852. eCollection 2021. | Side Effects | Review |
| 34093119 | Indeed, many studies have shown that acupuncture has acute analgesic and prophylactic effects on migraine without obvious side effects (Li et al.,; Zhao et al.,; Govind,). | Front Neurosci. 2021 May 20;15:674852. doi: 10.3389/fnins.2021.674852. eCollection 2021. | Side Effects | Review |
| 34122180 | ; (2) how effective is acupuncture for the management of PMD in comparison with standard care; and (3) when acupuncture is used as an adjuvant therapy to standard care, could it further enhance the therapeutic effect or reduce the side effects of Western pharmacotherapy? | Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. | Side Effects | Review |
| 34122180 | Not enough studies reported if acupuncture could reduce the side effects of HRT or antidepressants, as only one study with a small sample size addressed this comparison. | Front Psychiatry. 2021 May 28;12:666988. doi: 10.3389/fpsyt.2021.666988. eCollection 2021. | Side Effects | Review |
| 34122601 | Head acupuncture is more friendly to headache, insomnia, and other neurological diseases because of its unique role, with the rising number of insomnia cases, the side effects of sleeping pills are obvious, so scholars have a strong interest in acupuncture treatment of insomnia. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Side Effects Insomnia | Review |
| 34122601 | With people's awareness of the side effects of drugs in the treatment of insomnia, there are more and more clinical studies on the treatment of insomnia with scalp acupuncture alone or in combination. | Evid Based Complement Alternat Med. 2021 May 22;2021:6621993. doi: 10.1155/2021/6621993. eCollection 2021. | Side Effects Insomnia | Review |
| 34262271 | Juan et al reported that acupuncture combined with exercise therapy can reduce exercise-induced fatigue, which is a side effect of exercise, and improve the effect of pulmonary rehabilitation in patients with stable COPD. | Int J Chron Obstruct Pulmon Dis. 2021 Jul 7;16:2023-2037. doi: 10.2147/COPD.S313439. eCollection 2021. | Side Effects | Review |
| 34306150 | According to the literature, CAM therapy for EM dysmenorrhea, including herbs (herbal prescriptions, extracts, and patents), acupuncture, and Chinese herbal medicine enema (CHM enema), is effective for relieving dysmenorrhea with fewer unpleasant side effects when compared to hormonal and surgical treatments. | Evid Based Complement Alternat Med. 2021 Jul 2;2021:6663602. doi: 10.1155/2021/6663602. eCollection 2021. | Side Effects | Review |
| 34336626 | Once acupuncture is put into practice to achieve the desired mechanism, other things to consider are side effects from the procedure. | Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. | Side Effects | Review |
| 34336626 | More specifically, a systemic review on acupuncture safety that looked at nine different studies found that the most common side effects were: needle pain, tiredness, and bleeding. | Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. | Side Effects Bleeding | Review |
| 34336626 | Because acupuncture is a procedure that can produce potentially adverse side effects, the FDA has a close regulation on the needles used to perform acupuncture to ensure the safety and sterility of the procedure. | Anesth Pain Med. 2021 Apr 3;11(2):e113627. doi: 10.5812/aapm.113627. eCollection 2021 Apr. | Side Effects | Review |
| 34349826 | Various acupuncture treatments can be combined, with no risk of addiction, no side effects, convenient application and at a low cost, demonstrating the unique advantages of TCM in the treatment of cancer pain. | Evid Based Complement Alternat Med. 2021 Jul 26;2021:5558590. doi: 10.1155/2021/5558590. eCollection 2021. | Cancer Pain Side Effects | Review |
| 34349826 | The effect of acupuncture combined with three-step analgesic drug therapy for treatment of cancer pain was analyzed in terms of response rate, numerical rating scale (NRS), side effect rates, times of burst pain, onset time, and duration of response (DOR). | Evid Based Complement Alternat Med. 2021 Jul 26;2021:5558590. doi: 10.1155/2021/5558590. eCollection 2021. | Cancer Pain Side Effects | Review |
| 34349826 | Forest plot of side effect rates of acupuncture combined with three-step analgesic drugs versus three-step analgesic drugs alone for cancer pain. | Evid Based Complement Alternat Med. 2021 Jul 26;2021:5558590. doi: 10.1155/2021/5558590. eCollection 2021. | Cancer Pain Side Effects | Review |
| 34430628 | Importantly, these studies observed greater symptomatic improvement, better long-term effects, lower relapse rates, and fewer side effects in patients treated with acupuncture. | Ann Transl Med. 2021 Jul;9(14):1187. doi: 10.21037/atm-21-2779. | Side Effects | Review |
| 34526816 | Prolonged clinical practice proved acupuncture compound analgesia therapy in OPU has the advantages of safety, high efficiency, fast recovery, and few side effects. | J Pain Res. 2021 Sep 9;14:2833-2849. doi: 10.2147/JPR.S319923. eCollection 2021. | Side Effects | Review |
| 34629905 | Patients received opioids and acupuncture for pain relief with the central outcome assessment of pain and other side effects. | Clin Epidemiol. 2021 Oct 2;13:907-919. doi: 10.2147/CLEP.S324193. eCollection 2021. | Pain Relief Side Effects | Review |
| 34629905 | In contrast, the side effects of acupuncture are rarely reported. | Clin Epidemiol. 2021 Oct 2;13:907-919. doi: 10.2147/CLEP.S324193. eCollection 2021. | Side Effects | Review |
| 34629905 | Considering the minor side effects of acupuncture compared with drug prescriptions, acupuncture is suggested to be a safer option to choose for the clinical management of OIC patients. | Clin Epidemiol. 2021 Oct 2;13:907-919. doi: 10.2147/CLEP.S324193. eCollection 2021. | Side Effects | Review |
| 34646653 | Acupuncture is a widely used alternative therapy that is well tolerated and has fewer side effects compared to drugs used in pharmacologic treatment. | Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. | Side Effects | Review |
| 34646653 | One of the most common side effects of acupuncture is micro bleeding which is defined as bleeding that took from 10 to 30 seconds to resolve. | Cureus. 2021 Aug 31;13(8):e17601. doi: 10.7759/cureus.17601. eCollection 2021 Aug. | Side Effects Bleeding | Review |
| 34658755 | A popular second therapy that is being approved for the induction of analgesia and attenuates VH with fewer side effects includes electro-acupuncture (EA). | Front Neurosci. 2021 Sep 28;15:696843. doi: 10.3389/fnins.2021.696843. eCollection 2021. | Side Effects | Review |
| 34658755 | Some alternative therapies, including acupuncture, have been known to be effective treatment protocols that possess efficient therapeutic effects and minimum side effects compared with pharmacotherapy. | Front Neurosci. 2021 Sep 28;15:696843. doi: 10.3389/fnins.2021.696843. eCollection 2021. | Side Effects | Review |
| 34667434 | Acupuncture-related side effects occurred only in 8% of patients, were characterized by low intensity, and included subcutaneous haemorrhages, petechiae, and fainting. | Contemp Oncol (Pozn). 2021;25(2):88-94. doi: 10.5114/wo.2021.105969. Epub 2021 May 7. | Side Effects | Review |
| 34667434 | The most common side effects resulting from acupuncture needling is local pain (3.3% patients), bruising (3.2%), minor bleeding (1.4%), and orthostatic problems (0.5%). | Contemp Oncol (Pozn). 2021;25(2):88-94. doi: 10.5114/wo.2021.105969. Epub 2021 May 7. | Side Effects Bleeding | Review |
| 34675729 | Given its non-pharmacological basis, acupuncture also obviates the concerns with respect to toxicity and AEs that commonly occur when using hypnotics/sedatives, such as hangover, tolerance, increased alertness, and even endocrinological, hematological or cardiovascular events, and concerns regarding common side effects of contemporary antidepressive agents, such as dry mouth, cardiovascular/gastrointestinal side effects, seizure, bleeding, sexual dysfunction, weight gain, and even suicidality. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Cardiovascular Endocrinology Toxic Side Effects Side Effects Bleeding | Review |
| 34675729 | Whether reduced use of conventional drugs can be made up by the addition of acupuncture is a topic with important clinical significance because reduction of dosage in conventional drugs means fewer risks of side effects. | Nat Sci Sleep. 2021 Oct 12;13:1823-1863. doi: 10.2147/NSS.S332474. eCollection 2021. | Side Effects | Review |
| 34675990 | Systematic Review with Meta-Analysis: Effectiveness and Safety of Acupuncture as Adjuvant Therapy for Side Effects Management in Drug Therapy-Receiving Breast Cancer Patients | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | To investigate the potential benefits and safety of acupuncture on managing side effects induced by drug therapies in patients with breast cancer using a PRISMA standard systematic review and meta-analysis. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | The primary outcome and all subgroup analyses showed statistically significant improvements in the management of side effects by real acupuncture. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | Several systemic reviews had discussed some aspects of cancer treatment side effects by acupuncture, but recent updates are unavailable on the specific benefits of acupuncture to the breast cancer patients receiving drug therapy. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | studied the clinical benefits of acupuncture on hormone therapy-related side effects in breast cancer, while the study by Roberts et al. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | A systematic review researching the beneficial effects of herbal medicine on side-effect management is available; however, a comprehensive meta-analysis of using acupuncture for managing the side effects induced by drug therapies is still deficient. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | Acupuncture has a systematic approach that could enhance the body conditions and relieve symptoms as a whole; therefore, most of the case studies included multiple side-effect managements. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | Only RCTs studying the effect of acupuncture on relieving the side effects of drug therapies that treat breast cancer were included. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | Primary outcomes were standard mean differences (SMD) of side effect level indices between the experimental group (real acupuncture) and control group (sham acupuncture/no treatment/waitlist control). | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | Acupuncture could alleviate the side effects brought about by drug therapy that treat breast cancer to a certain extent. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | To further illustrate the adjuvant effects of acupuncture in managing the side effects, subgroup analysis was performed according to the symptoms caused by drug therapies. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | The result of this meta-analysis undoubtedly showed the beneficial effects of acupuncture in the management of side effects from drug therapies on patients with breast cancer. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | The purpose of the subgroup analysis was to ensure that acupuncture is effective in reducing the common side effects. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | Acupuncture can manage the side effects of drug therapies with minimal risk and promising benefits. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34675990 | This meta-analysis showed that acupuncture could effectively reduce the side effects induced by drug therapies in patients with breast cancer. | Evid Based Complement Alternat Med. 2021 Oct 12;2021:9949777. doi: 10.1155/2021/9949777. eCollection 2021. | Side Effects | Review |
| 34729102 | The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects | Review |
| 34729102 | In this review, we summarized the clinical application of acupuncture and EA in alleviating the cancer symptoms, reducing the cancer treatment-related side-effects, and relieving the cancer pain. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Cancer Pain Side Effects | Review |
| 34729102 | In this review, we introduced the effects of acupuncture and EA on cancer-related symptoms and side-effects, the possible mechanisms behind acupuncture, and the hindrance against the wide application of acupuncture and EA in cancer-related treatment. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects | Review |
| 34729102 | Effects of acupuncture and EA on the symptoms and side-effects related to cancer and cancer treatment | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects | Review |
| 34729102 | Because some of those symptoms and side-effects are tightly related, we mainly discussed the therapeutic potential of acupuncture and EA in some of those symptoms and side-effects in this review. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects | Review |
| 34729102 | A recent case report study demonstrated that acupuncture is an effective and safe therapeutic option for reducing cancer pain with minimal side-effects and lowering the need for narcotic analgesics. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Cancer Pain Side Effects | Review |
| 34729102 | Although many efforts have been made to understand the effects of acupuncture and EA in the treatment of cancer-related symptoms and side-effects, the mechanisms by which acupuncture and EA achieve therapeutic benefits remain largely unknown. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects | Review |
| 34729102 | The studies on mechanisms of acupuncture and EA for treating other cancer-related symptoms and side-effects are limited. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects | Review |
| 34729102 | This review summarized the application of acupuncture and EA in cancer patients for improving cancer-related symptoms and side-effects, such as fatigue, insomnia, chemotherapy-associated dyspepsia syndrome (CADS), radiation-induced xerostomia (RIX), anxiety and depression, and pain (Table 1). | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects Insomnia Anxiety Depression | Review |
| 34729102 | Given that the actual mechanisms of acupuncture and EA remain largely unknown, more basic and clinical studies are needed to endorse the broad clinical application of acupuncture and EA in the treatment of cancer-related symptoms and side-effects. | J Cancer. 2021 Oct 11;12(23):7003-7009. doi: 10.7150/jca.55803. eCollection 2021. | Side Effects | Review |
| 34760630 | CAM has become popular, and methods such as acupuncture, CHBT, Chinese herbal ointments, and oral herbal medicines have been successfully used to treat UP with few side effects. | Tzu Chi Med J. 2020 Dec 24;33(4):350-358. doi: 10.4103/tcmj.tcmj_151_20. eCollection 2021 Oct-Dec. | Side Effects | Review |
| 34760630 | Omega-3 and zinc sulfate supplements with minimal adverse effects can be used first; external treatments without side effects, such as acupuncture, CHBT, and Chinese herbal-based cream, can then be considered. | Tzu Chi Med J. 2020 Dec 24;33(4):350-358. doi: 10.4103/tcmj.tcmj_151_20. eCollection 2021 Oct-Dec. | Side Effects Adverse Reactions | Review |
| 34828543 | In traditional Chinese medicine, acupuncture is widely used in numerous musculoskeletal disorders, as it can induce analgesic effects with minimal and minor side effects. | Healthcare (Basel). 2021 Nov 2;9(11):1497. doi: 10.3390/healthcare9111497. | Analgesic Effect Side Effects | Review |
| 34930039 | Nevertheless, as of today, there was only one systematic review focused on the breast cancer population for acupoint stimulation-managed treatment- related side-effects in breast cancer, although there are published academic studies evaluating the association between acupoint injection/acupuncture and chemotherapy related complications in patients with lung cancer regardless of the tumor type. | Integr Cancer Ther. 2021 Jan-Dec;20:15347354211063884. doi: 10.1177/15347354211063884. | Side Effects | Review |
| 34983587 | The guideline proposed three recommendations: (1) a strong recommendation for the treatment of acupuncture rather than no treatment to relieve pain in patients with moderate to severe cancer pain; (2) a weak recommendation for the combination treatments with acupuncture/acupressure to reduce pain intensity, decrease the opioid dose, and alleviate opioid-related side effects in moderate to severe cancer pain patients who are using analgesics; and (3) a strong recommendation for acupuncture in breast cancer patients to relieve their aromatase inhibitor-induced arthralgia. | Chin Med. 2022 Jan 5;17(1):8. doi: 10.1186/s13020-021-00558-4. | Cancer Pain Side Effects | Review |
| 34983587 | We suggest a combination treatment with acupuncture/acupressure to reduce pain intensity, decrease opioid dose, and alleviate opioid-related side effects in moderate to severe cancer pain patients who are using analgesics (weak recommendation, low certainty evidence). | Chin Med. 2022 Jan 5;17(1):8. doi: 10.1186/s13020-021-00558-4. | Cancer Pain Side Effects | Review |
| 34992414 | Morphine and acetaminophen-induced hepatotoxicity can also be relieved by acupuncture through the amelioration of antioxidant defense systems. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Toxic Side Effects | Review |
| 34992414 | Acupuncture directly activates the endogenous HPA axis and plays an anti-inflammatory role, which prevents overdose of exogenous cortisol and its related side effects. | J Inflamm Res. 2021 Dec 21;14:7191-7224. doi: 10.2147/JIR.S341581. eCollection 2021. | Side Effects | Review |
| 35036916 | Many cancer patients turn to complementary and alternative therapies such as acupuncture or moxibustion to manage their symptoms due to fear of side effects of drugs that can further exacerbate cancer symptoms. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Side Effects | Review |
| 35036916 | Consequently, many cancer patients turn to complementary and alternative therapies such as acupuncture or moxibustion to manage their symptoms due to fear of side effects of drugs that can further exacerbate cancer symptoms. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Side Effects | Review |
| 35036916 | Due to moxibustion and acupuncture-related adverse events being poorly underreported, keywords and index terms related to adverse events such as side effects and safety were therefore not included in the searches; however, this outcome was investigated and assessed at a later stage for those studies that were included in the analysis of this review. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Side Effects | Review |
| 35036916 | This study suggested that the effect of using moxibustion and acupuncture to treat tumour patients with insomnia is as good as conventional medicine, but its long-term effect is better with no side effects. | Palliat Care Soc Pract. 2022 Jan 10;16:26323524211070569. doi: 10.1177/26323524211070569. eCollection 2022. | Side Effects Insomnia | Review |
| 35055089 | In addition, there are also asserted acupuncture abilities to augment post-ischemia CBF by promoting VEGF and angiogenin-1-mediated angiogenesis and the improved release of vasoactive mediators (i.e., acetylcholine and NO); moreover, it can improve regional energy metabolism, regulate blood lipid metabolism to resist cerebral free radical damage, reduce the number of excitatory amino acids to lower neurogenic toxicity, and reduce calcium overloading. | Int J Mol Sci. 2022 Jan 14;23(2):907. doi: 10.3390/ijms23020907. | Toxic Side Effects | Review |
| 35055089 | The therapeutic intervention pathways seem to be similar to those asserted for acupuncture: increase cerebral blood flow, regulate oxidative stress, attenuate glutamate excitotoxicity, suppress Ca2+ overload in the infarct region of the brain, causing neuroinflammatory reactions, maintain BBB integrity, inhibit apoptosis, increase growth factor production, and induce cerebral ischemic tolerance. | Int J Mol Sci. 2022 Jan 14;23(2):907. doi: 10.3390/ijms23020907. | Toxic Side Effects Blood Flow | Review |
| 35090456 | Although acupuncture has advantages on improving the sequelae of stroke, we still should attach great importance to its limitation and side effect. | BMC Complement Med Ther. 2022 Jan 28;22(1):28. doi: 10.1186/s12906-021-03484-y. | Side Effects | Review |
| 35145373 | Meanwhile, acupuncture may be used in patients with refractory FD who had poorer responses to conventional medical therapy or suffered from serious side effects. | Front Neurosci. 2022 Jan 25;15:781215. doi: 10.3389/fnins.2021.781215. eCollection 2021. | Side Effects | Review |
| 35145373 | Acupuncture combined with pharmacological treatment may have the potential to reduce the side effects of medical treatment, but it remained controversial due to limited research. | Front Neurosci. 2022 Jan 25;15:781215. doi: 10.3389/fnins.2021.781215. eCollection 2021. | Side Effects | Review |
| 35145373 | It was emphasized that acupuncture combined with pharmacological treatment not only enhanced the improvement FD symptoms but also reduced the side effects of the medical treatment which were the main cause for high dropout rates with drug treatment. | Front Neurosci. 2022 Jan 25;15:781215. doi: 10.3389/fnins.2021.781215. eCollection 2021. | Side Effects | Review |
| 35168522 | It was emphasized that acupuncture combined with antidepressant pharmacological treatment not only enhanced the improvement of primary and secondary depressive symptoms but also reduced the side effects of the medical treatment, which is the main cause for high dropout rates with drug treatment. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects | Review |
| 35168522 | Compared with pharmacological treatments, acupuncture has the advantages of low cost and minimal side effects. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects | Review |
| 35168522 | Besides, an RCT compared SSRIs alone versus SSRIs together with manual acupuncture or electroacupuncture in 477 moderate to severely depressed patients, identifying that compared with SSRIs alone, both manual acupuncture and electroacupuncture were significantly better on 17-item Hamilton Depression Rating Scale (HDRS) response rate, HDRS-17 early-onset rate, Self-Rating Depression Scale (SDS), Clinical Global Impression (CGI) and Rating Scale foe Side Effects (SERS), indicating that acupuncture have therapeutic effects in addition to SSRIs alone in patients with moderate to severe depression, and was well tolerated. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects Depression | Review |
| 35168522 | In a study, 58 participants with ischemic PSD received acupuncture and placebo starch tablets treatment or fluoxetine tablets add body acupuncture treatment during a 12-week intervention period, found that both acupuncture and fluoxetine could reduce the depressive scores, but the former had no obvious adverse reaction and side effects, indicating that the effects of acupuncture were comparable to first-line treatments in PSD patients | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects Adverse Reactions | Review |
| 35168522 | A systematic review that recruited 7 available RCTs with 535 patients in 2020 found that compared with medicine therapy, acupuncture significantly decreased the scores of pain and depressive symptoms assessing by Visual Analogue Scale (VAS) and HDRS, separately, and lower side effects in PRD patients. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects | Review |
| 35168522 | This review supported the view that acupuncture can be used in patients with poorer responses to conventional medical therapy or suffering from serious side effects. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects | Review |
| 35168522 | A prospective study with 15 patients diagnosed with mild PPD to explore the effects of acupuncture found that acupuncture alone could decrease the depressive scores and alleviate symptoms of mild PPD, with no side effects. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects | Review |
| 35168522 | Acupuncture combined with antidepressant pharmacological treatment may have the potential to reduce the side effects of medical treatment, but it remains controversial due to limited research. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects | Review |
| 35168522 | Although acupuncture has been used to manage various physical symptoms that may present as side effects from antidepressants, including nausea, insomnia, weight gain, and sexual dysfunction, few studies have directly demonstrated that acupuncture could improve the side effects of antidepressants. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects Insomnia Nausea and Vomiting | Review |
| 35168522 | This research found no significant difference between the two groups in therapeutic response rates and depressive score, whereas the patients in the acupuncture group showed better improvement than the sham acupuncture group in side-effects of antidepressants. | Curr Neuropharmacol. 2022;20(4):738-750. doi: 10.2174/1570159X19666210609162809. | Side Effects | Review |
| 35211071 | Advantages of acupuncture, as non-pharmacological therapy, including safety, convenience, and minimal side effect profile. | Front Neurol. 2022 Feb 7;12:723424. doi: 10.3389/fneur.2021.723424. eCollection 2021. | Side Effects | Review |
| 35233354 | Acupuncture modulates multiple molecules and signaling pathways that lead to excitotoxicity, inflammation, oxidative stress, neuron death, and survival. | Tzu Chi Med J. 2021 Apr 19;34(1):35-43. doi: 10.4103/tcmj.tcmj_275_20. eCollection 2022 Jan-Mar. | Toxic Side Effects | Review |
| 35241146 | GABA-mediated inhibition also plays a role in acupuncture-induced reduction of excitotoxicity. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Toxic Side Effects | Review |
| 35241146 | Acupuncture may increase the survival rate, migration and homing ability of the implated cells and maintain cell functions by increasing the cerebral blood flow, modulating the blood brain barrier (BBB) integrity, and attenuating the excitotoxicity and inflammatory responses. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Toxic Side Effects Blood Flow | Review |
| 35241146 | Acupuncture can modulate the brain microenvironment and reduce the cell loss caused by excitotoxicity and oxidative stress, which could  further enhance cell therapy efficiency. | Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y. | Toxic Side Effects | Review |
| 35313481 | Acupuncture can provide analgesia by releasing endogenous opioids with a few side effects and high safety and could be an effective alternative therapy for analgesia to the clinical use rate of drugs to avoid potential adverse events caused by medicines. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Side Effects | Review |
| 35313481 | As a safe analgesic therapy with low side effects and low economic burden, acupuncture has a lower incidence of adverse events than drug therapy. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Side Effects | Review |
| 35313481 | When combined with drugs to treat pain diseases, acupuncture can enhance the analgesic effect and reduce patients' dependence on drugs and even reduce the side effects of drugs. | Evid Based Complement Alternat Med. 2022 Mar 12;2022:1451342. doi: 10.1155/2022/1451342. eCollection 2022. | Analgesic Effect Side Effects | Review |
| 35341147 | Acupuncture and moxibustion techniques are widely used in pain management, which cause fewer side effects than other pharmaceutical alternatives. | Evid Based Complement Alternat Med. 2022 Mar 16;2022:6886465. doi: 10.1155/2022/6886465. eCollection 2022. | Side Effects | Review |
| 35360658 | Therefore, there has been increasing interest in complementary and alternative medicines (CAMs) for the treatment of UC, of which traditional Chinese medicine (TCM) is one.. As a natural CAM with an excellent safety profile and few side effects, acupuncture is increasingly recognized as a viable adjunct to other management strategies in many Western countries. | Evid Based Complement Alternat Med. 2022 Mar 22;2022:8362892. doi: 10.1155/2022/8362892. eCollection 2022. | Side Effects | Review |
| 35380733 | In multiple SRMs, acupuncture was found to be effective in reducing postsurgical pain compared with sham acupuncture, controls, and usual care, with a reduction in opioid need (21% opioid reduction at 8Â hours, 23% at 24Â hours, and 29% at 72Â hours post surgery) and with a lowered incidence of opioid-related side effects such as nausea, dizziness, sedation, pruritus, and urinary retention. | Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. | Side Effects Nausea and Vomiting Urinary Retention Sedation | Review |
| 35380733 | An SRM of auricular acupuncture for acute and postsurgical pain found that it provided immediate pain relief and benefit at 48Â hours, was equivalent to analgesics, and had fewer side effects. | Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. | Pain Relief Side Effects | Review |
| 35380733 | Additionally, acupuncture was effective, safe, and well tolerated for post-tonsillectomy pain in children, with no significant side effects. | Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. | Side Effects | Review |
| 35380733 | SRs and surveys have clarified that acupuncture is safe when performed by appropriately trained practitioners, with infrequent minor side effects, such as feeling relaxed, elated, or tired or having sensation or itching at the point of insertion. | Pain Med. 2022 Aug 31;23(9):1582-1612. doi: 10.1093/pm/pnac056. | Side Effects | Review |
| 35462893 | Compared with other therapeutic methods, acupuncture is non-toxic and has a simple operation and low cost, but its mechanism remains unclear. | Front Pharmacol. 2022 Apr 7;13:875103. doi: 10.3389/fphar.2022.875103. eCollection 2022. | Toxic Side Effects | Review |
| 35492706 | In light of the challenges in the current management of DI, we conducted this systematic review, aiming to address the following research questions: (1) could acupuncture be used as an isolated remedy for DI; (2) how effective and safe was acupuncture in the treatment of DI in comparison with standard care; and (3) when acupuncture was applied as an adjunctive remedy of standard care, could it further enhance the efficacy or minimize the side effects of Western pharmacotherapy? | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Side Effects | Review |
| 35492706 | Another two RCTs employed the Asberg Side Effects Rating Scale (SERS) and found that SERS scores were significantly lower in the combined therapy, indicating that AEs caused by mirtazapine or paroxetine were diminished when acupuncture was superimposed. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Side Effects | Review |
| 35492706 | We recommend the inclusion of internationally endorsed and standard tools such as the Antidepressant Side-Effect Checklist, the UKU Side Effects Rating Scale, and/or the Frequency, Intensity, and Burden of Side Effects Rating Scale in future studies to truly reflect the real impact of acupuncture on antidepressant-induced AEs. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Side Effects | Review |
| 35492706 | A previous systematic review revealed that acupuncture was helpful in reducing antidepressant-induced side reactions in the first 6 weeks of the treatment period among patients with depression. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Side Effects Depression | Review |
| 35492706 | Hence, whether acupuncture produces a similar benefit of attenuating side effects caused by antidepressants and/or hypnotics during the early onset of DI would be an attractive direction for future investigation. | Front Psychiatry. 2022 Apr 15;13:863134. doi: 10.3389/fpsyt.2022.863134. eCollection 2022. | Side Effects | Review |
| 35496051 | Acupuncture, as a treatment with fewer side effects which has been practiced for over 2500 years in China, is widely used to manage chronic pain. | Biomed Res Int. 2022 Apr 21;2022:6561633. doi: 10.1155/2022/6561633. eCollection 2022. | Side Effects | Review |
| 35496051 | In our study, we consider acupuncture as an effective treatment in relieving pain and improving function for people who are troubled by KOA, especially those refusing conventional drug therapy because of unbearable side effects. | Biomed Res Int. 2022 Apr 21;2022:6561633. doi: 10.1155/2022/6561633. eCollection 2022. | Side Effects | Review |
| 35547876 | Besides, various acupoint stimulation modalities such as electroacupuncture (EA), transcutaneous electrical acupoint stimulation (TEAS), bee venom acupuncture therapy (BVA), and laser acupuncture (LA) have been used for the management of various chemotherapy side effects. | Front Oncol. 2022 Apr 25;12:864046. doi: 10.3389/fonc.2022.864046. eCollection 2022. | Side Effects | Review |
| 35586692 | Acupuncture is known to be safe, relatively free of side effects, and without adverse physiological impact. | Evid Based Complement Alternat Med. 2022 May 9;2022:4807271. doi: 10.1155/2022/4807271. eCollection 2022. | Side Effects | Review |
| 35721049 | Given the side effect of TPA or sedatives, a reduced dosage when combined with acupuncture should be another key reflection of the effect of acupuncture. | Front Med (Lausanne). 2022 Jun 3;9:865035. doi: 10.3389/fmed.2022.865035. eCollection 2022. | Side Effects | Review |
| 35725779 | Similarly, in a recent meta-analysis by Li et al (2021) including 19 articles (N= 1502 patients), in which the efficacy and safety of acupuncture combined with the WHO three-step analgesic drug ladder for cancer pain was studied, addition of acupuncture to the drug ladder increased pain relief response rates (relative risk/risk ratio (RR) = 1.12, 95% CI: 1.08 to 1.17), reduced NRS score (standard mean difference (SMD) = â1.10, 95% CI: â1.86 to â0.35, ), reduced the rate of side effects (RR = 0.45, 95% CI: 0.38 to 0.53, ), reduced the burst pain rate (SMD = â1.38; 95% CI: â2.44 to â0.32, ), shortened analgesia effect onset time, and extended the duration of response. | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Cancer Pain Pain Relief Side Effects | Review |
| 35725779 | examining six high quality RCTs investigating the effect of acupuncture on CIPN by using specific pain scores (N=386 cancer patients), it was found that acupuncture significantly improved pain scores (â1.21, 95% [CI] = â1.61 to â0.82, P < .00001) and neurological symptoms based on Functional Assessment of Cancer Therapy/Neurotoxicity questionnaire scores (â2.02, 95% CI = â2.21 to â1.84, P < .00001). | Blood Rev. 2022 Nov;56:100985. doi: 10.1016/j.blre.2022.100985. Epub 2022 Jun 13. | Toxic Side Effects | Review |
| 35755043 | The limited side effect profile of acupuncture makes it an advantageous treatment option, however, factors including cost, time, limited access, and aversion to needles may serve as barriers to treatment. | Front Med (Lausanne). 2022 Jun 9;9:868079. doi: 10.3389/fmed.2022.868079. eCollection 2022. | Side Effects | Review |
| 35755043 | The limited side effect profile of acupuncture makes it an advantageous treatment option for alopecia. | Front Med (Lausanne). 2022 Jun 9;9:868079. doi: 10.3389/fmed.2022.868079. eCollection 2022. | Side Effects | Review |
| 35755043 | Yet, given the beneficial side effect profile associated with acupuncture and notable improvements reported in the literature, it is a treatment modality that warrants further exploration. | Front Med (Lausanne). 2022 Jun 9;9:868079. doi: 10.3389/fmed.2022.868079. eCollection 2022. | Side Effects | Review |
| 35755043 | Although this acupuncture is viewed as generally safe practice, careful evaluation of adverse events is needed for a better understanding of the side effect profile associated with its practice. | Front Med (Lausanne). 2022 Jun 9;9:868079. doi: 10.3389/fmed.2022.868079. eCollection 2022. | Side Effects | Review |
| 35788539 | acupuncture) have been observed and organ toxicity from the use of specific TCAM products has been seen, if the consumer does not disclose TCAM use, then there is a risk of misdiagnosis and/or inappropriate treatment. | Drug Saf. 2022 Jul;45(7):713-735. doi: 10.1007/s40264-022-01189-w. Epub 2022 Jul 5. | Toxic Side Effects | Review |
| 35800002 | In 2021, Meng's research found that acupuncture can improve the Glutamic Acid and Gamma-aminobutyric acid levels in PCIV rats, which lessens the excitability toxicity of ischemic stroke. | Evid Based Complement Alternat Med. 2022 Jun 28;2022:3740856. doi: 10.1155/2022/3740856. eCollection 2022. | Toxic Side Effects | Review |
| 35832526 | Studies in recent years have shown that the acupuncture treatment of acute renal colic caused by urinary calculi has rapid pain relief, reliable curative effect, and no toxic side effects, but the sample sizes of these trials were small, and their conclusions were seen as overly positive. | Evid Based Complement Alternat Med. 2022 Jul 4;2022:7140038. doi: 10.1155/2022/7140038. eCollection 2022. | Pain Relief Toxic Side Effects Side Effects Kidney | Review |
| 35875071 | Acupuncture combined with antiemetics could reduce the incidence of CINV, improve the quality of life of patients and reduce the incidence of adverse side effects of antiemetic drugs. | Front Oncol. 2022 Jul 8;12:888651. doi: 10.3389/fonc.2022.888651. eCollection 2022. | Side Effects | Review |
| 35875071 | The addition of acupuncture played a vital role in reducing toxicity and enhancsing efficiency. | Front Oncol. 2022 Jul 8;12:888651. doi: 10.3389/fonc.2022.888651. eCollection 2022. | Toxic Side Effects | Review |
| 35875071 | This study indicated that acupuncture combined with antiemetics could reduce the incidence of CINV, improve the quality of life of patients and reduce the incidence of adverse side effects of antiemetic drugs. | Front Oncol. 2022 Jul 8;12:888651. doi: 10.3389/fonc.2022.888651. eCollection 2022. | Side Effects | Review |
| 35884060 | However, the positive results of these studies indicate that acupuncture is both accepted, feasible, beneficial, and without significant side effects in the pediatric emergency department, inpatient, and outpatient clinic settings. | Children (Basel). 2022 Jul 19;9(7):1076. doi: 10.3390/children9071076. | Side Effects | Review |
| 35922617 | Importantly, acupuncture has few side effects and high compliance, effectively demonstrating that it should be considered a valid alternative and/or complementary strategy. | Pain Ther. 2022 Dec;11(4):1095-1112. doi: 10.1007/s40122-022-00415-8. Epub 2022 Aug 3. | Side Effects | Review |
| 35922617 | Compared with other interventions, acupuncture also has the advantages of minimal side effects, low cost, and high patient compliance. | Pain Ther. 2022 Dec;11(4):1095-1112. doi: 10.1007/s40122-022-00415-8. Epub 2022 Aug 3. | Side Effects | Review |
| 35923845 | That acupuncture could control acute postoperative pain and reduce the side effects of pharmacological analgesia was supported by the reference with the highest centrality. | J Pain Res. 2022 Jul 27;15:2085-2104. doi: 10.2147/JPR.S371399. eCollection 2022. | Side Effects | Review |
| 35978992 | Acupuncture has a certain effect as a complementary therapy on pain management of CIBP, which not only mitigates the pain intensity but also improves the quality of life and reduces the incidence of opioids' side effects, although the evidence level was very low. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Side Effects | Review |
| 35978992 | The adverse events reported by these studies were largely related to opioids' side effects, including nausea or vomiting, constipation, dizziness, itching, delirium, drowsiness, and abdominal distention, and there is no report about the adverse effects associated with acupuncture treatment. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Side Effects Adverse Reactions Nausea and Vomiting | Review |
| 35978992 | It should be noted that adverse events reported in this review were largely related to opioids' side effects rather than acupuncture treatment, and the incidence of side effects of opioids was lower than that in the control group. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Side Effects | Review |
| 35978992 | Acupuncture has a certain effect as a complementary therapy on pain management of CIBP, which not only mitigates the pain intensity but also improves the quality of life, and reduces the incidence of opioid side effects. | Front Pain Res (Lausanne). 2022 Aug 1;3:925013. doi: 10.3389/fpain.2022.925013. eCollection 2022. | Side Effects | Review |
| 36119472 | Acupuncture also alleviates side effects induced by chemotherapy or radiotherapy such as nausea and vomiting, cancer-related pain, fatigue, insomnia, and the QOL. | Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. | Side Effects Insomnia Nausea and Vomiting | Review |
| 36119472 | Eight trials reported side effects but did not state in detail whether they were caused by acupuncture or chemotherapy. | Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. | Side Effects | Review |
| 36119472 | However, all the trials reported that the side effects of involved acupuncture groups were lower than those of the control group. | Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. | Side Effects | Review |
| 36119472 | This indicated that conventional Western medicine combined with acupuncture had the advantage of reducing toxicity and increasing effects in the treatment of lung cancer, reflecting the advantages of acupuncture in lung cancer such as safety, effectiveness, urgency, acceptability, and applicability. | Front Oncol. 2022 Sep 2;12:921151. doi: 10.3389/fonc.2022.921151. eCollection 2022. | Toxic Side Effects | Review |
| 36186098 | According to the intervention, 14 SRs/MAs (68%, 14/19) reported the side effects of acupuncture, one (20%, 1/5) for MBP, and five for natural products (83.3%, 5/6) (Supplementary Table S8). | J Pharmacopuncture. 2022 Sep 30;25(3):186-198. doi: 10.3831/KPI.2022.25.3.186. | Side Effects | Review |
| 36203799 | In spinal cord injury patients, acupuncture could be useful to improve pain and other complications if patients experience side effects or have no (or a weak) response to a conventional treatment. | Front Neurosci. 2022 Sep 20;16:940343. doi: 10.3389/fnins.2022.940343. eCollection 2022. | Side Effects | Review |
| 36230606 | This is a scoping review of published literature on the usefulness of acupuncture-related therapies and herbal medicine in alleviating the side effects associated with breast cancer treatments. | Cancers (Basel). 2022 Sep 26;14(19):4683. doi: 10.3390/cancers14194683. | Side Effects | Review |
| 36230606 | The effectiveness of acupuncture-related therapies and herbal medicine in managing the side effect is not fully understood. | Cancers (Basel). 2022 Sep 26;14(19):4683. doi: 10.3390/cancers14194683. | Side Effects | Review |
| 36230606 | Most studies suggested beneficial effects of acupuncture and herbal medicine on managing pain, daily function, and quality of life in patients going through AIA, CIPN, and/or lymphedema, with mild side effects. | Cancers (Basel). 2022 Sep 26;14(19):4683. doi: 10.3390/cancers14194683. | Side Effects | Review |
| 36230606 | In summary, the AEs from complementary therapies of acupuncture and herbal medicine were associated with mild side effects, and in general, safe. | Cancers (Basel). 2022 Sep 26;14(19):4683. doi: 10.3390/cancers14194683. | Side Effects | Review |
| 36268156 | Acupuncture can regulate viscera in the treatment of insomnia and has the advantages of safety and no side effects. | Comput Intell Neurosci. 2022 Oct 11;2022:1081713. doi: 10.1155/2022/1081713. eCollection 2022. | Side Effects Insomnia | Review |
| 36291216 | Compared with many rehabilitation therapies, acupuncture has the advantages of safety, simple operation, non-toxic side effects, and relatively low cost. | Brain Sci. 2022 Sep 23;12(10):1282. doi: 10.3390/brainsci12101282. | Toxic Side Effects Side Effects | Review |
| 36340786 | Because of the difficulty in overcoming side effects, including hypersensitivity reactions, cardiovascular disease, and cerebrovascular disease, more clinical studies are required to make acupuncture an alternative strategy to target CGRP. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Cardiovascular Side Effects | Review |
| 36340786 | However, a variety of psychotropic side effects make its clinical application ineffective, making acupuncture a potential alternative therapy for regulating the endocannabinoid system. | Front Neurosci. 2022 Oct 20;16:1022455. doi: 10.3389/fnins.2022.1022455. eCollection 2022. | Side Effects | Review |
| 36381700 | Due to the potential adverse toxicities related to traditional treatments for chronic pain, integrative medicine techniques such as massage, osteopathic spinal manipulation, acupuncture, and yoga are extremely relevant in the treatment of chronic pain and should be considered a leading treatment option. | Cureus. 2022 Oct 5;14(10):e29963. doi: 10.7759/cureus.29963. eCollection 2022 Oct. | Toxic Side Effects | Review |
| 36388203 | Compared with drug therapy, acupuncture is increasingly used in the integrative and complementary treatment of pain diseases due to its long-term effectiveness, good tolerance, and fewer side effects. | Front Neurol. 2022 Oct 26;13:1010410. doi: 10.3389/fneur.2022.1010410. eCollection 2022. | Side Effects | Review |
| 36388203 | Acupuncture as a preventive measure for migraine is safer and more effective than common medicines due to less side effects and lower risks and has been widely accepted in Western countries. | Front Neurol. 2022 Oct 26;13:1010410. doi: 10.3389/fneur.2022.1010410. eCollection 2022. | Side Effects | Review |
| 36439200 | At present, most of the research on the action of acupuncture on the neurological deficits of ischemic stroke has been from the perspective of reducing neuroinflammation, represented by reducing microglial activation and the release of proinflammatory mediators and neurotoxic substances. | Front Cell Neurosci. 2022 Nov 10;16:817732. doi: 10.3389/fncel.2022.817732. eCollection 2022. | Toxic Side Effects | Review |
| 36475060 | Acupuncture is a safe method and has a low rate of side effects. | Open Med (Wars). 2022 Nov 23;17(1):1869-1882. doi: 10.1515/med-2022-0598. eCollection 2022. | Side Effects | Review |
| 36482655 | Acupuncture, electroacupuncture, pharmacoacupuncture, moxibustion, and chuna manual treatment are some of the procedures used to treat occipital neuralgia in China and Korea, all of which have little to no side effects. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Neuralgia Side Effects | Review |
| 36482655 | The findings of this study add to the mounting body of evidence that demonstrates acupuncture to be a useful therapeutic method with few negative side effects. | Medicine (Baltimore). 2022 Dec 2;101(48):e31891. doi: 10.1097/MD.0000000000031891. | Side Effects | Review |
| 36570846 | According to multiple meta-analyses, acupuncture is a valuable option for individuals who are unsuitable for prokinetic therapy and experience fewer side effects than gastrointestinal motility drugs used to treat functional dyspepsia. | Front Neurosci. 2022 Dec 8;16:1038945. doi: 10.3389/fnins.2022.1038945. eCollection 2022. | Side Effects | Review |
| 36590284 | Acupuncture and moxibustion in traditional Chinese medicine has a long history, and its advantages of quit onset, simplicity and low side effects also have an irreplaceable role in modern treatment. | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Side Effects | Review |
| 36590284 | Comparison the relatively low number of adverse events in the experimental group compared to the control group indicates that acupuncture has fewer side effects in the treatment of CRI and has advantages in terms of safety compared to other treatments (e.g., sham acupuncture and cognitive behavioral therapy). | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Side Effects | Review |
| 36590284 | Moreover, although acupuncture treatment has fewer side effects, there is no clear solution to these adverse effects, which is what we need to improve in the use of acupuncture in the future, such as pain, itching, bruising, colds, etc. | Front Neurosci. 2022 Dec 15;16:1026759. doi: 10.3389/fnins.2022.1026759. eCollection 2022. | Side Effects Adverse Reactions | Review |
| 36620677 | Compared with pharmacological therapy, acupuncture therapy has less side effects. | Front Psychiatry. 2022 Dec 23;13:1067329. doi: 10.3389/fpsyt.2022.1067329. eCollection 2022. | Side Effects | Review |
| 36626458 | Acupuncture can effectively relieve the anxiety symptoms of generalized anxiety disorder patients with fewer side effects, but randomized controlled trials with large sample size and high quality are also required to support the result. | Medicine (Baltimore). 2022 Dec 9;101(49):e30076. doi: 10.1097/MD.0000000000030076. | Side Effects Anxiety | Review |
| 36626458 | Besides, acupuncture reported fewer side effects. | Medicine (Baltimore). 2022 Dec 9;101(49):e30076. doi: 10.1097/MD.0000000000030076. | Side Effects | Review |
| 36628350 | When the treatment target was not acute gout, studies that could not analyze the results of heat stimuli during acupuncture were excluded, and no restrictions on side effects were applied for the analysis of the safety of heat stimuli during acupuncture. | J Pharmacopuncture. 2022 Dec 31;25(4):301-316. doi: 10.3831/KPI.2022.25.4.301. | Side Effects | Review |
| 36670425 | A systematic review and meta-analysis of 13 randomized controlled trials (RCTs) with 750 cases showed that acupuncture could help AD patients with cognitive impairment and that it was more effective than traditional Western medicine on the Mini-Mental State Examination (MMSE), the Activity of Daily Living (ADL), and the AD Assessment Scale-Cognitive scales, with no serious side effects. | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Side Effects | Review |
| 36670425 | Acupuncture may improve cognitive impairment in AD rats by inhibiting the production of toxic proteins and promoting their clearance. | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Toxic Side Effects | Review |
| 36670425 | It has been reported that acupuncture might promote correct folding in potentially toxic proteins; for example, acupuncture at Danzhong (CV17), Zhongwan (CV12), Qihai (CV6), Xuhai (SP10), and ST36 improved cognitive function and increased neuronal numbers in senescence-accelerated mouse prone 8 (SAMP8) mice, accompanied by increased expression of HSP84 and HSP86. | Chin Med. 2023 Jan 20;18(1):8. doi: 10.1186/s13020-023-00707-x. | Cognitive Function Toxic Side Effects | Review |
| 36698826 | The acupuncture-related side effects of the four studies that provided relevant information are summarized in Supplementary Table 2. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Side Effects | Review |
| 36698826 | Forest plot comparing the overall risk of side effects between acupuncture and control groups. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Side Effects | Review |
| 36698826 | Compared to the well-known side effects of NSAIDs such as gastrointestinal complications (e.g., bleeding, ulcer perforation), the relative safety of acupuncture and its association with few serious adverse events render it a promising option for patients with pain not responding to regular medications and those experiencing serious drug-related side effects. | Front Med (Lausanne). 2023 Jan 9;9:1100014. doi: 10.3389/fmed.2022.1100014. eCollection 2022. | Side Effects Bleeding | Review |
| 36704010 | Comparisons between acupuncture and antiepileptics are meaningful because antiepileptics are the recommended first-line treatment for PHN with fewer side effects than other effective drugs. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Side Effects | Review |
| 36704010 | Nevertheless, these two treatments both had the most AEs, combining the side effects of both antiepileptic and acupuncture treatments. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Side Effects | Review |
| 36704010 | Based on the evidence from our analysis, acupuncture-related therapies may be potential treatment options for PHN and are relatively safe with only mild side effects. | Front Neurosci. 2023 Jan 10;16:1056102. doi: 10.3389/fnins.2022.1056102. eCollection 2022. | Side Effects | Review |
| 36778899 | Mounting evidence supports the application of acupuncture to prevent and treat migraines, due to its long-term effectiveness, good tolerance, and fewer side effects. | Front Neurosci. 2023 Jan 27;16:1097450. doi: 10.3389/fnins.2022.1097450. eCollection 2022. | Side Effects | Review |
| 36845439 | Acupuncture was suggested as a widely used non-pharmacological intervention for pain control, with the advantages of various treatment modalities (i.e., MA, EA, and WA) and minor side effects (Qiao et al.,). | Front Neurosci. 2023 Feb 9;17:1097830. doi: 10.3389/fnins.2023.1097830. eCollection 2023. | Side Effects | Review |
| 36862907 | In terms of safety, drug adverse reactions as dizziness, dry mouth, drowsiness, gastrointestinal symptoms, and adverse reactions of acupuncture for subcutaneous bleeding, strong sense of needle legacy, at the end of the withdrawal or acupuncture treatment can obviously relieve or disappear, never reported left side effects. | Medicine (Baltimore). 2023 Mar 3;102(9):e33006. doi: 10.1097/MD.0000000000033006. | Side Effects Adverse Reactions Bleeding | Review |
| 36873742 | However, their analysis suggests that acupuncture may have a positive impact on cognition and daily performance with few side effects. | Front Aging. 2023 Feb 16;4:1143408. doi: 10.3389/fragi.2023.1143408. eCollection 2023. | Side Effects | Review |
| 36875696 | Many systematic reviews (SRs) have demonstrated that acupuncture results in cognitive enhancement in MCI, improved subjective cognitive decline, and diminished post-stroke cognitive impairment without obvious side effects. | Front Aging Neurosci. 2023 Feb 15;15:1007436. doi: 10.3389/fnagi.2023.1007436. eCollection 2023. | Side Effects | Review |
| 36950556 | Acupuncture is well-tolerated with little risk of serious side effects. | Front Oncol. 2023 Mar 6;13:1077961. doi: 10.3389/fonc.2023.1077961. eCollection 2023. | Side Effects | Review |
| 36964825 | The laser used in acupuncture is of low energy intensity and causes no side effects when used under appropriate conditions. | Lasers Med Sci. 2023 Mar 25;38(1):92. doi: 10.1007/s10103-023-03754-w. | Side Effects | Review |
| 37025199 | However, a large number of clinical studies have reported that (i) long-term oral chemical prescription drugs can have debilitating anticholinergic side effects, resulting in poor patient compliance with the drugs and a high recurrence rate and (ii) on the contrary, acupuncture has good green clinical efficacy in the treatment of depression. | Front Neurol. 2023 Mar 21;14:1151421. doi: 10.3389/fneur.2023.1151421. eCollection 2023. | Side Effects Depression | Review |
| 37091130 | Acupuncture antagonizes excitotoxicity damage by activating syn-NMDAR, and enhancing neuronal survival signals this way may be advantageous over conventional NMDA receptor antagonists. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Toxic Side Effects | Review |
| 37091130 | Moreover, acupuncture for cerebrovascular disease involves reducing the excitotoxic effects by enhancing syn-NMDAR and inhibiting eNMDAR, thus reducing the intracellular Ca2+ concentration. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Toxic Side Effects | Review |
| 37091130 | In summary, it can be reasonably speculated that acupuncture may be a pathway that regulates the expression and activity of glutamate and its receptors and reduces excitotoxicity to interfere with cell death in the penumbra region to improve the survival rate of penumbra cells and protect neurons. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Neuroprotection Toxic Side Effects | Review |
| 37091130 | Acupuncture can be neuroprotective by inhibiting the excitotoxic effects of glutamate by activating the expression activity of GABA. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Neuroprotection Toxic Side Effects | Review |
| 37091130 | Therefore, acupuncture improvement of language function in PSA patients may be due to the upregulation of GABA expression by acupuncture treatment, activating the cAMP/PKA/CREB signaling pathway, and inhibiting excitotoxic effects. | Behav Neurol. 2023 Apr 12;2023:9445381. doi: 10.1155/2023/9445381. eCollection 2023. | Toxic Side Effects Language Function | Review |
| 37187857 | Additionally, acupuncture is cost effective with fewer severe potential side-effects compared to opioid therapy. | Front Pain Res (Lausanne). 2023 Apr 28;4:1020038. doi: 10.3389/fpain.2023.1020038. eCollection 2023. | Side Effects | Review |
| 37200784 | A meta-analysis of acupuncture for PTSD in adults found that it can help with PTSD core symptoms and has fewer side effects (Grant et al.,). | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Side Effects | Review |
| 37200784 | Acupuncture was reported to counteract the neurotoxicity of excitatory amino acids, reduce stress-induced nerve cell damage, and promote neuroprotective effects and fear memory regression by upregulating BDNF in the PFC (Chen et al.,) and downregulating mPFC GABAARal (Zhu et al.,). | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Neuroprotection Toxic Side Effects | Review |
| 37229426 | 3 studies (Jiang et al.,; Chen et al.,; Han et al.,) reported that the incidence of side effects like dizziness, vomiting and insomnia in acupuncture combined with conventional medicines were lower than those in conventional medicines alone. | Front Neurosci. 2023 May 9;17:1125626. doi: 10.3389/fnins.2023.1125626. eCollection 2023. | Side Effects Insomnia Nausea and Vomiting | Review |
| 37229426 | Madopar or other dopaminergic drugs combined with acupuncture have been used to treat PD patients by physicians aiming to reduce side effects and increase therapeutic effectiveness (Xia et al.,; de Amorim Aroxa et al.,; Wu et al.,). | Front Neurosci. 2023 May 9;17:1125626. doi: 10.3389/fnins.2023.1125626. eCollection 2023. | Side Effects | Review |
| 37229426 | This research also found that acupuncture therapy has many characteristics, few side effects, relatively safe, and in the treatment of PD, it has a certain antagonistic effect on the adverse reactions caused by madopar or other dopaminergic drugs, such as nausea and vomiting, which are typical symptoms of the gastrointestinal adverse reactions. | Front Neurosci. 2023 May 9;17:1125626. doi: 10.3389/fnins.2023.1125626. eCollection 2023. | Side Effects Adverse Reactions Nausea and Vomiting | Review |
| 37256179 | On the other hand, compared with western medicine, acupuncture has a greater advantage in security and can reduce side effects happening, such as nausea, vomiting, constipation, and dizziness. | Front Oncol. 2023 May 15;13:1169458. doi: 10.3389/fonc.2023.1169458. eCollection 2023. | Side Effects Nausea and Vomiting | Review |
| 37297763 | However, in situations where the side effects of conventional medical drugs and surgical treatments are not small, acupuncture treatment among TCM treatments can be an alternative to conventional treatment, because it has few side effects and is effective in reducing pain. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Side Effects | Review |
| 37297763 | In one study of acupuncture, side effects such as minor local bleeding or hematoma, pain at the site of needle insertion, and vegetative symptoms were reported in the experimental acupuncture group. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Side Effects Bleeding | Review |
| 37297763 | In one study of auricular acupuncture, side effects such as auricular haemorrhage, local pain, headache, and hip pain after needle placement were reported in both the experimental acupuncture group and the control sham acupuncture group. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Side Effects | Review |
| 37297763 | Similar side effects have been reported in other studies related to acupuncture and auricular acupuncture; therefore, they can be considered common side effects of auricular acupuncture. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Side Effects | Review |
| 37297763 | One of the greatest advantages of acupuncture is its low incidence of side effects; no fatal side effects were reported in the 12 RCTs included in this study. | Healthcare (Basel). 2023 Jun 1;11(11):1624. doi: 10.3390/healthcare11111624. | Side Effects | Review |
| 37383912 | Acupuncture and moxibustion can reduce the intensity and duration of pain, promote quick recovery of the activities before the injury, and assist in the development of a suitable rehabilitation training regime while bearing almost no side effects. | World J Clin Cases. 2023 May 26;11(15):3395-3407. doi: 10.12998/wjcc.v11.i15.3395. | Side Effects | Review |
| 37396891 | Therefore, a conclusion could be drawn with caution that the application of acupuncture in sedation in gastrointestinal endoscopy was considered effective. | Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. | Side Effects Sedation | Review |
| 37397275 | The cited references with the most citations indicated acupuncture therapies were beneficial to postoperative pain management and reduced the incidence of opioid-related side effects. | J Pain Res. 2023 Jun 27;16:2189-2204. doi: 10.2147/JPR.S415998. eCollection 2023. | Side Effects | Review |
| 37397439 | The other six studies reported no adverse events or side effects of neuromodulation (t-VNS, at-VNS, ear-electro-acupuncture) (Vijayalakshmi et al.,; Yang et al.,; Zhang et al.,; Luo et al.,; Cao et al.,; Wei et al.,) (Table 2). | Front Neurosci. 2023 Jun 15;17:1151892. doi: 10.3389/fnins.2023.1151892. eCollection 2023. | Side Effects | Review |
| 37525791 | Compared to other pain management methods like pharmaceuticals, acupuncture is considered to have rare and infrequent serious side effects. | Cureus. 2023 Jun 30;15(6):e41203. doi: 10.7759/cureus.41203. eCollection 2023 Jun. | Side Effects | Review |
| 37533466 | Acupuncture, a traditional Chinese medicine procedure used in which sterile needles are inserted into specific areas of the body, is often used to treat PI because of its low side effects. | Front Neurol. 2023 Jul 18;14:1180393. doi: 10.3389/fneur.2023.1180393. eCollection 2023. | Side Effects | Review |
| 37542321 | Compared with medication, acupuncture therapy is more cost-effective and has fewer side effects, making it an attractive option for the auxiliary regulation and prevention of various chronic diseases. | BMC Complement Med Ther. 2023 Aug 4;23(1):278. doi: 10.1186/s12906-023-04103-8. | Side Effects | Review |
| 37543780 | Acupuncture, as a traditional Chinese medical method, has achieved good clinical efficacy in treating PSD, offering the benefits of convenience, cost-effectiveness, no side effects, and significant effectiveness. | Medicine (Baltimore). 2023 Aug 4;102(31):e34561. doi: 10.1097/MD.0000000000034561. | Side Effects | Review |
| 37546517 | Compared with drug therapy, acupuncture has the advantages of low cost and less side effects. | Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. | Side Effects | Review |
| 37546517 | Acupuncture, as a convenient and quick treatment method, can prevent and cure diseases by stimulating the biological function of the human body, significantly improving symptoms, and having no side effects. | Neuropsychiatr Dis Treat. 2023 Aug 1;19:1741-1753. doi: 10.2147/NDT.S421540. eCollection 2023. | Side Effects | Review |
| 37551854 | Studies have depicted that acupuncture can relieve cancer pain and reduce the dose and side effects of analgesics. | Integr Cancer Ther. 2023 Jan-Dec;22:15347354231192017. doi: 10.1177/15347354231192017. | Analgesic Effect Cancer Pain Side Effects | Review |
| 37568485 | Therefore, this side effect generally necessitates additional pharmacologic and rehabilitative interventions, as well as alternative strategies, like acupuncture and osteopathy. | J Clin Med. 2023 Aug 2;12(15):5083. doi: 10.3390/jcm12155083. | Side Effects | Review |
| 37568485 | In developing a program that combines osteopathy, acupuncture and rehabilitation, the objectives should be aimed at reducing constipation symptoms, improving quality of life, and decreasing the reliance on constipation medications laden with side effects. | J Clin Med. 2023 Aug 2;12(15):5083. doi: 10.3390/jcm12155083. | Side Effects | Review |
| 37614513 | The advantages of acupuncture consist of safety, rare and mild side effects, and high patient acceptance. | Front Oncol. 2023 Aug 8;13:1198286. doi: 10.3389/fonc.2023.1198286. eCollection 2023. | Side Effects | Review |
| 37655096 | Although the safety of acupuncture was poorly described in the included studies, the available data suggested that acupuncture is a safe treatment with only mild side effects. | Front Oncol. 2023 Aug 15;13:1232754. doi: 10.3389/fonc.2023.1232754. eCollection 2023. | Side Effects | Review |
| 37675019 | A prospective observational study on acupuncture for chronic pain in Germany included 454920 patients, of whom more than 30% were over 60 years old, and reported mild side-effects (pain, hematoma, and bleeding) in 7.9% of patients. | Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. | Side Effects Bleeding | Review |
| 37675019 | Some researchers believe that some side-effects of acupuncture are due to malpractice by acupuncturists, which can be avoided by strengthening training. | Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. | Side Effects | Review |
| 37675019 | Third, acupuncture is a simple supplementary therapy with mild side-effects, which prevent patients from taking additional drugs, especially opioids, to improve patient compliance. | Front Nephrol. 2022 Nov 9;2:1006506. doi: 10.3389/fneph.2022.1006506. eCollection 2022. | Side Effects | Review |
| 37678839 | Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Side Effects | Review |
| 37678839 | Due to its good analgesic effects and minimal side effects, acupuncture is a viable option for treatment of inflammatory pain. | Mol Pain. 2023 Jan-Dec;19:17448069231202882. doi: 10.1177/17448069231202882. | Analgesic Effect Side Effects Inflammatory Pain | Review |
| 37760483 | Complementary therapies, such as acupuncture, yoga and herbal medicine are used by many patients with cancer to relieve symptoms and side effects from anti-cancer treatment. | Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. | Side Effects | Review |
| 37760483 | Peripheral neuropathy symptoms measured with the FACT-NTX (Functional Assessment of Cancer Therapy-Neurotoxicity) subscale seem to be significantly relieved in cancer patients receiving acupuncture. | Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. | Toxic Side Effects | Review |
| 37760483 | The side effects of three-step analgesics, such as nausea, vomiting, constipation and dizziness, were significantly reduced in patients using acupuncture compared to using only three-step analgesic drugs. | Cancers (Basel). 2023 Sep 11;15(18):4513. doi: 10.3390/cancers15184513. | Side Effects Nausea and Vomiting | Review |
| 37795371 | Because of its clinical efficacy, cost efficiency and limited side effects, the use of acupuncture is recommended for a wide variety of diseases by the WHO. | Front Endocrinol (Lausanne). 2023 Sep 18;14:1236370. doi: 10.3389/fendo.2023.1236370. eCollection 2023. | Side Effects | Review |
| 37799620 | Side effects, such as subcutaneous hematoma during acupuncture occurred in two patients in the treatment group, and a mild burning sensation occurred during moxibustion in one patient in the control group. | J Pharmacopuncture. 2023 Sep 30;26(3):211-226. doi: 10.3831/KPI.2023.26.3.211. | Side Effects | Review |
| 37810368 | Various acupuncture intervention methods are used, including manual acupuncture, filiform-fire needling, tube needle, thumb-tack needles, ear point pressure, intradermal needle, and acupoint injection, and there are little side effects. | Acupunct Herb Med. 2023 Jun;3(2):83-95. doi: 10.1097/HM9.0000000000000062. Epub 2023 Mar 13. | Side Effects | Review |
| 37861487 | Studies have shown that the effect of acupuncture is mainly to enhance the effect of chemotherapy and reduce the toxic side effects of chemotherapy, so as to improve the quality of life. | Medicine (Baltimore). 2023 Oct 20;102(42):e35000. doi: 10.1097/MD.0000000000035000. | Toxic Side Effects Side Effects | Review |
| 37861487 | Second, acupuncture can reduce the side effects of chemoradiotherapy and improve the quality of life. | Medicine (Baltimore). 2023 Oct 20;102(42):e35000. doi: 10.1097/MD.0000000000035000. | Side Effects | Review |
| 37861487 | Studies have shown that acupuncture at acupoints can stimulate the secretion of β-enikacin and interleukin-2 in the human body, which can effectively relieve pain with rapid action and no side effects. | Medicine (Baltimore). 2023 Oct 20;102(42):e35000. doi: 10.1097/MD.0000000000035000. | Side Effects | Review |
| 37928412 | These side effects included subcutaneous cyanosis, pain, hot flushes, and insatiable hunger caused by acupuncture; pain, fatigue, and bruising caused by acupressure; allergic skin reactions caused by auricular acupressure. | Asia Pac J Oncol Nurs. 2023 Sep 18;10(11):100308. doi: 10.1016/j.apjon.2023.100308. eCollection 2023 Nov. | Side Effects | Review |
| 37942632 | Criteria for inclusion were as follows: (a) types of studies: only SRs/MAs that based on randomized controlled trials (RCTs) were included; (b) participants: patients with cancer and suffering from pain, regardless of cancer stage and current treatment; (c) types of interventions: acupuncture was an eligible intervention, while comparative intervention could be analgesics or sham acupuncture; (d) types of outcomes: response rate, reduction of pain intensity, onset time of pain relief, duration of pain relief, reduction of analgesic dose, and side effects. | Integr Cancer Ther. 2023 Jan-Dec;22:15347354231210288. doi: 10.1177/15347354231210288. | Pain Relief Side Effects | Review |
| 37954034 | The results showed that acupuncture can improve the total effective rate [OR=3.43 (95% CI: 2.71, 4.35), moderate credibility], reduce the incidence of adverse reactions [OR=0.45 (95% CI: 0.32, 0.63), moderate credibility], reduce the TESS score (side effect scale) [MD=â1.83 (95% CI: â2.94, â0.71), very low credibility. | Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. | Side Effects Adverse Reactions | Review |
| 37954034 | Acupuncture, as a green therapy, provides another option for SZ without significant side effects. | Neuropsychiatr Dis Treat. 2023 Nov 7;19:2381-2400. doi: 10.2147/NDT.S428518. eCollection 2023. | Side Effects | Review |
| 37998449 | In two other studies, falls and withdrawals due to discomfort from acupuncture were reported as side effects in the acupuncture group. | Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. | Side Effects | Review |
| 37998449 | No serious adverse events directly related to acupuncture were reported, and some side effects resolved after stopping the intervention for specific acupoints. | Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. | Side Effects | Review |
| 37998449 | Generally, side effects of acupuncture can include infection, damage to the internal organs, such as pneumothorax or heart injury, injury to the central or peripheral nerves, local discomforts such as bruising and pain, and other reactions such as orthostatic problems, worsening of symptoms, headache, and fatigue. | Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. | Side Effects | Review |
| 37998449 | The side effects of auricular acupuncture tend to focus on infection, local discomfort, and autonomic reactions, such as dizziness, as it does not cause damage to the internal organs or central nervous system. | Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. | Side Effects | Review |
| 37998449 | Therefore, the adverse effects of auricular acupuncture and acupuncture for PTSD military personnel in distal acupoints are not fatal, and the side effects are within the controllable range of the operator. | Healthcare (Basel). 2023 Nov 14;11(22):2957. doi: 10.3390/healthcare11222957. | Side Effects Adverse Reactions | Review |
| 38046583 | In contrast, acupuncture has the advantages of high safety and no toxic side effects and is more easily accepted by patients with heart, liver, and kidney damage. | Front Neurol. 2023 Nov 17;14:1268626. doi: 10.3389/fneur.2023.1268626. eCollection 2023. | Toxic Side Effects Side Effects Kidney | Review |
| 38125513 | Electroacupuncture (EA) demonstrates efficacy comparable to pharmacological antidepressants for major depressive disorder with fewer side effects. | Heliyon. 2023 Nov 28;9(12):e22798. doi: 10.1016/j.heliyon.2023.e22798. eCollection 2023 Dec. | Side Effects | Review |
| 38162142 | Finally, studies on side effects do not allow for an adequate evaluation of the safety of acupuncture because of the small amount of literature mentioned. | Front Cardiovasc Med. 2023 Dec 14;10:1147135. doi: 10.3389/fcvm.2023.1147135. eCollection 2023. | Side Effects | Review |
| 38165870 | Traditional Chinese medicine (TCM) including traditional Chinese medicine decoction, Chinese patent medicine, acupuncture and other therapies have certain advantages in improving the efficiency of disease treatment, reducing the recurrence rate, reducing side effects and improving the condition. | PLoS One. 2024 Jan 2;19(1):e0291685. doi: 10.1371/journal.pone.0291685. eCollection 2024. | Side Effects | Review |
| 38165870 | Most studies have focused on the effectiveness of acupuncture, and little attention has been paid to the side effects. | PLoS One. 2024 Jan 2;19(1):e0291685. doi: 10.1371/journal.pone.0291685. eCollection 2024. | Side Effects | Review |
| 2125871 | Appendectomy under acupuncture anesthesia (A.A) is save and effective, easy and economical, and helpful to recover with no side effects to patients, organism. | Zhen Ci Yan Jiu. 1990;15(3):167-9. | Side Effects | Clinic |
| 20209977 | Postoperative urinary retention, pain severity I and II and the cases with intoxic response in AAA and control groups were 1 and 8, 16 and 6, 4 and 14, and 1 and 9, separately. | Zhen Ci Yan Jiu. 2009 Dec;34(6):403-5. | Toxic Side Effects Urinary Retention | Clinic |
| 20209977 | The effects of AAA group were significantly superior to those of control group in lessening urinary retention and toxication, and in inducing analgesia (P<0.05). | Zhen Ci Yan Jiu. 2009 Dec;34(6):403-5. | Toxic Side Effects Urinary Retention | Clinic |
| 24576720 | Transcutaneous electric acupoint stimulation reduces intra-operative remifentanil consumption and alleviates postoperative side-effects in patients undergoing sinusotomy: a prospective, randomized, placebo-controlled trial. | Br J Anaesth. 2014 Jun;112(6):1075-82. doi: 10.1093/bja/aeu001. Epub 2014 Feb 26. | Side Effects | Clinic |
| 24576720 | BACKGROUND: Although opioids are widely used as analgesics in general anaesthesia, they have unpleasant side-effects and can delay postoperative recovery. | Br J Anaesth. 2014 Jun;112(6):1075-82. doi: 10.1093/bja/aeu001. Epub 2014 Feb 26. | Side Effects | Clinic |
| 24576720 | Acupuncture and related techniques are effective for acute and chronic pain, and reduces some side-effects. | Br J Anaesth. 2014 Jun;112(6):1075-82. doi: 10.1093/bja/aeu001. Epub 2014 Feb 26. | Side Effects | Clinic |
| 24576720 | We assessed the effect of transcutaneous electric acupoint stimulation (TEAS) on intra-operative remifentanil consumption and the incidences of anaesthesia-related side-effects. | Br J Anaesth. 2014 Jun;112(6):1075-82. doi: 10.1093/bja/aeu001. Epub 2014 Feb 26. | Side Effects | Clinic |
| 24576720 | The primary end point was intraoperative remifentanil consumption and the secondary endpoints were recovery quality and anaesthesia-related side-effects. | Br J Anaesth. 2014 Jun;112(6):1075-82. doi: 10.1093/bja/aeu001. Epub 2014 Feb 26. | Side Effects | Clinic |
| 24576720 | CONCLUSION: The use of TEAS significantly reduced intra-operative remifentanil consumption and alleviated postoperative side-effects in patients undergoing sinusotomy. | Br J Anaesth. 2014 Jun;112(6):1075-82. doi: 10.1093/bja/aeu001. Epub 2014 Feb 26. | Side Effects | Clinic |
| 24865978 | Electroacupuncture has been demonstrated to be effective at alleviating pain and postoperative side-effects. | Anaesthesia. 2014 Aug;69(8):832-9. doi: 10.1111/anae.12639. Epub 2014 May 28. | Side Effects | Clinic |
| 24865978 | Further, postoperative pain scores and the incidence of side-effects were all lower in the transcutaneous electric acupoint stimulation group. | Anaesthesia. 2014 Aug;69(8):832-9. doi: 10.1111/anae.12639. Epub 2014 May 28. | Side Effects | Clinic |
| 24865978 | In conclusion, transcutaneous electric acupoint stimulation can significantly improve the quality of recovery and decrease the incidence of anaesthesia-related side-effects for patients undergoing ambulatory surgery. | Anaesthesia. 2014 Aug;69(8):832-9. doi: 10.1111/anae.12639. Epub 2014 May 28. | Side Effects | Clinic |
| 15992223 | We aimed to evaluate the efficacy and side-effects of either transcutaneous electrical acupoint stimulation (TEAS) or Ondansetron compared to a control group receiving no treatment in the prevention of postoperative retching and vomiting. | J Altern Complement Med. 2005 Jun;11(3):407-13. doi: 10.1089/acm.2005.11.407. | Side Effects Nausea and Vomiting | Clinic |
| 15992223 | OUTCOME MEASURES: The frequency of retching and vomiting attacks and side-effects were noted on the day of surgery in the postanesthesia care unit and the day surgery care unit, on the day of surgery after discharge, and on the first day after surgery. | J Altern Complement Med. 2005 Jun;11(3):407-13. doi: 10.1089/acm.2005.11.407. | Side Effects Nausea and Vomiting | Clinic |
| 15992223 | In the ondansetron group, side-effects were seen in more patients than in the other groups (p < 0.001). | J Altern Complement Med. 2005 Jun;11(3):407-13. doi: 10.1089/acm.2005.11.407. | Side Effects | Clinic |
| 17959591 | BACKGROUND: Despite prophylactic measures, hypotension remains a common side-effect of spinal anaesthesia for parturients. | Br J Anaesth. 2008 Jan;100(1):78-81. doi: 10.1093/bja/aem306. Epub 2007 Oct 24. | Side Effects | Clinic |
| 20131040 | Clinical efficacy of acupuncture on the morphine-related side effects in patients undergoing spinal-epidural anesthesia and analgesia. | Chin J Integr Med. 2010 Feb;16(1):71-4. doi: 10.1007/s11655-010-0070-7. Epub 2010 Feb 4. | Side Effects | Clinic |
| 20131040 | OBJECTIVE: To investigate the effects of acupuncture on the morphine-related side effects (nausea, vomiting, itchiness and gastrointestinal disorders) in patients undergoing anesthesia and analgesia and try to find the clinical mechanism of acupuncture. | Chin J Integr Med. 2010 Feb;16(1):71-4. doi: 10.1007/s11655-010-0070-7. Epub 2010 Feb 4. | Side Effects Nausea and Vomiting | Clinic |
| 20131040 | CONCLUSIONS: On the basis of this study, it is obviously seen that acupuncture could: decrease the incidence of morphine-related side effects (nausea and vomiting, itchiness and gastrointestinal disorders) when the spinal cord conduct is normal. | Chin J Integr Med. 2010 Feb;16(1):71-4. doi: 10.1007/s11655-010-0070-7. Epub 2010 Feb 4. | Side Effects Nausea and Vomiting | Clinic |
| 12411789 | BACKGROUND: Antiemetic drugs are costly, are associated with variable efficacy, and can produce unwanted side effects when used for prophylaxis against postoperative nausea and vomiting. | Anesthesiology. 2002 Nov;97(5):1075-81. doi: 10.1097/00000542-200211000-00008. | Side Effects Nausea and Vomiting | Clinic |
| 11506105 | CONCLUSION: Preoperative insertion of intradermal needles reduces postoperative pain, the analgesic requirement, and opioid-related side effects after both upper and lower abdominal surgery. | Anesthesiology. 2001 Aug;95(2):349-56. doi: 10.1097/00000542-200108000-00015. | Side Effects | Clinic |
| 15777857 | Intraoperative anesthetic requirement, incidence of analgesia-related side effects, inflammation parameters and success of patients' blinding were also recorded. | Pain. 2005 Apr;114(3):320-327. doi: 10.1016/j.pain.2004.08.021. | Side Effects | Clinic |
| 15777857 | Pain intensity on VAS-100 and incidence of analgesia-related side effects were similar in both groups. | Pain. 2005 Apr;114(3):320-327. doi: 10.1016/j.pain.2004.08.021. | Side Effects | Clinic |
| 12406527 | In the present study, we examined the effects of preoperative electroacupuncture (EA) at classical bilateral acupuncture points (Zusanli, also known as ST-36) on postoperative pain and opioid-related side effects. | Pain. 2002 Oct;99(3):509-514. doi: 10.1016/S0304-3959(02)00261-0. | Side Effects | Clinic |
| 12406527 | We also found that sham-EA exerts a beneficial effect with respect to its pain relieving quality but not the side effect profiles. | Pain. 2002 Oct;99(3):509-514. doi: 10.1016/S0304-3959(02)00261-0. | Side Effects | Clinic |
| 12406527 | Our findings demonstrates that preoperative treatment with low-EA and high-EA can reduce postoperative analgesic requirements and associated side effects in patients undergoing lower abdominal surgery. | Pain. 2002 Oct;99(3):509-514. doi: 10.1016/S0304-3959(02)00261-0. | Side Effects | Clinic |
| 1544195 | The antiemetic effects and side-effects of P6 acupuncture and droperidol pre-treatment were evaluated in a randomized, patient- and observer-blinded study. | Can J Anaesth. 1992 Feb;39(2):151-4. doi: 10.1007/BF03008646. | Side Effects | Clinic |
| 25926298 | OBJECTIVES: To investigate the anaesthetic and analgesic effect of multipoint transcutaneous electrical acupuncture stimulation (TEAS) during supratentorial tumour resection for postoperative recovery and side effects. | Acupunct Med. 2015 Aug;33(4):270-6. doi: 10.1136/acupmed-2014-010749. Epub 2015 Apr 29. | Analgesic Effect Side Effects | Clinic |
| 25926298 | Postoperative pain, recovery and side effects were evaluated. | Acupunct Med. 2015 Aug;33(4):270-6. doi: 10.1136/acupmed-2014-010749. Epub 2015 Apr 29. | Side Effects | Clinic |
| 25926298 | Postoperative recovery and pain were significantly improved by TEAS (p<0.001), without the postoperative side effects. | Acupunct Med. 2015 Aug;33(4):270-6. doi: 10.1136/acupmed-2014-010749. Epub 2015 Apr 29. | Side Effects | Clinic |
| 25926298 | CONCLUSIONS: Multipoint TEAS at both proximal and distal points combined with TIVA can significantly decrease intraoperative sufentanil requirements, increase pain relief on postoperative day 1 and improve postoperative recovery of patients during supratentorial tumour resection, with no significant increase of side effects. | Acupunct Med. 2015 Aug;33(4):270-6. doi: 10.1136/acupmed-2014-010749. Epub 2015 Apr 29. | Pain Relief Side Effects | Clinic |
| 27437568 | No side effect related to TEAS was observed during the postoperative 48 hours. | Clin J Pain. 2017 Apr;33(4):340-347. doi: 10.1097/AJP.0000000000000400. | Side Effects | Clinic |
| 11754709 | MAIN OUTCOME MEASURES: Cocaine use during treatment and at the 3- and 6-month postrandomization follow-up based on urine toxicology screens; retention in treatment. | JAMA. 2002 Jan 2;287(1):55-63. doi: 10.1001/jama.287.1.55. | Toxic Side Effects | Clinic |
| 25047046 | Recent reviews support the effectiveness of acupuncture regimen in reducing postoperative pain, cumulative opioid consumption or opioid related side effects. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Side Effects | Clinic |
| 25047046 | This in particular seems to be of interest when taking into account patient populations that are at higher risk of suffering from side effects from local bleeding. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Side Effects Bleeding | Clinic |
| 25047046 | The safety of acupuncture has been described in depth, suggesting that acupuncture is free of severe side effects and being considered a safe intervention. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Side Effects | Clinic |
| 25047046 | There is a small number of trials dealing with the safety of press needles; one long-term observation over one year in cancer patients suggests a ratio of 10% of minor side effects, mostly rashes. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Side Effects | Clinic |
| 25047046 | It can be expected to provide valuable new information on the clinical effectiveness of acupuncture improving post anaesthetic recovery parameters, which are a) preoperative anxiety relief, b) perioperative variables of anaesthesia and narcotic guidance, c) the occurrence of postoperative pain and anaesthetic side effects such as PONV or shivering. | Trials. 2014 Jul 21;15:292. doi: 10.1186/1745-6215-15-292. | Side Effects Anxiety | Clinic |
| 25152761 | It is anticipated that the improvements in anesthetic technology and the enhancement of the lithotripsy apparatus will substantially reduce the amount of sedative anesthetic and analgesic administered and this, in turn, will decrease the side effects that arise from these drugs. | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Side Effects | Clinic |
| 25152761 | The following information was recorded during operation: (1) patients' requests for analgesia indicated by raising their hand during the operation as the time of first raising the hand, the number of times the hand was raised for analgesia, the pain visual analogue scale (VAS) values indicated by the patients, and the dosage opium derivative analgesic given; (2) the vital signs such as blood pressure, heart rate, and arterial oxygen partial pressure; and (3) any relevant side effects induced by sedatives and opium derivative analgesic such as nausea, vomit, dizziness, and itching. | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Heart Rate Side Effects Nausea and Vomiting Blood Pressure | Clinic |
| 25152761 | In addition, the following information was also recorded in the recovery room: (1) any side effects after operation; (2) the recovery time after anesthesia; and (3) a grading on the level of satisfaction with respect to pain control during the operation. | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Side Effects | Clinic |
| 25152761 | Gender, ASA, location of calculi, side effects of the analgesic, patients satisfaction regarding pain controllability, and relevant side effects caused by the opium derivative analgesic were assessed by the Ï 2 test or Fisher's exact test; specifically, when less than 20% of columns had expected values smaller than 5, the Ï 2 test was used and, conversely, when more than 20% of columns had values smaller than 5, Fisher's exact test was used. | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Side Effects | Clinic |
| 25152761 | Analgesic Side Effects Analysis (Table 6) | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Side Effects | Clinic |
| 25152761 | Each group was analyzed and compared based on the side effects of the analgesia, but there was no statistically significant variation. | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Side Effects | Clinic |
| 25152761 | showed that electroacupuncture can effectively reduce the side effects of ESWL, which benefits early recovery. | Evid Based Complement Alternat Med. 2014;2014:592319. doi: 10.1155/2014/592319. Epub 2014 Jul 23. | Side Effects | Clinic |
| 35647012 | During this period, severe hemodynamic abnormalities, severe stress response, obvious postoperative anesthesia side effects and high incidence of adverse reactions easily occur. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Side Effects Adverse Reactions Stress Response | Clinic |
| 36034956 | Studies have found that multimode analgesia can not only improve the analgesic effect but also reduce the side effects of anesthesia to maximize the effect/side effects ratio, so as to achieve balanced analgesia. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Analgesic Effect Side Effects Acupuncture Anesthesia Effect | Clinic |
| 23573118 | High-dose opioids are used for pain management, but they may cause side effects such as respiratory depression. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Side Effects Depression | Clinic |
| 23573118 | It is controversially discussed whether opioids after median sternotomy lead to side effects such as respiratory depression, vomiting, nausea, and sedation. | Evid Based Complement Alternat Med. 2013;2013:219817. doi: 10.1155/2013/219817. Epub 2013 Mar 14. | Side Effects Nausea and Vomiting Depression Sedation | Clinic |
| 23342207 | When the opioid related side effects were compared for each group, the results showed that the number of subjects who experienced dizziness in the acupuncture group was significantly lower than the control group (P < 0.05). | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Side Effects | Clinic |
| 23342207 | In 1980, WHO announced 43 types of different diseases that could be treated with acupuncture without any significant side effects. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Side Effects | Clinic |
| 23342207 | The opioid related side effects, such as nausea, vomiting, dizziness, and pruritus, were also documented in both groups at regular intervals. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Side Effects Nausea and Vomiting | Clinic |
| 23342207 | When opioid related side effects were compared, the results showed that the number of subjects with dizziness and nausea in the acupuncture group was significantly lower than the control group. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Side Effects Nausea and Vomiting | Clinic |
| 23342207 | In a study by Wang et al., they concluded that high transcutaneous acupoint electrical stimulation produced a significant decrease in the PCA opioid requirement and the opioid related side effects after low intra-abdominal surgery. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Side Effects | Clinic |
| 23342207 | They found that preoperative insertion of intradermal needles reduced postoperative pain, the analgesic requirement, and opioid-related side effects after both upper and lower abdominal surgery. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Side Effects | Clinic |
| 23342207 | The results for the opioid related side effects displayed that the subjects in the acupuncture group had less dizziness when compared to the other subjects of the control group, which had a statistical significance. | Korean J Pain. 2013 Jan;26(1):46-50. doi: 10.3344/kjp.2013.26.1.46. Epub 2013 Jan 4. | Side Effects | Clinic |
| 15937559 | The incidence of analgesia-related side effects, time to discharge from the anesthesia recovery room, heart rate and blood pressure were also recorded. | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Heart Rate Side Effects Blood Pressure | Clinic |
| 15937559 | The secondary endpoints were pain intensity assessed by the patients on VAS-100 at rest before acupuncture, 30 min after tracheal extubation, on discharge from the anesthesia recovery room and during the follow-up examination; total piritramide requirement in the anesthesia recovery room between surgery and discharge; duration of general anesthesia, time from tracheal extubation to discharge and duration of night's sleep after surgery (in hours) self-reported during the follow-up examination; and the incidence of analgesia-related side effects (nausea and vomiting, sedation and pruritus). | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Side Effects Nausea and Vomiting Sedation | Clinic |
| 15937559 | The Chi-square test was used to analyze the incidence of analgesia-related side effects. | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Side Effects | Clinic |
| 15937559 | No patient reported side effects from pharmacological analgesia or AA. | Evid Based Complement Alternat Med. 2005 Jun;2(2):185-189. doi: 10.1093/ecam/neh097. Epub 2005 May 11. | Side Effects | Clinic |
| 26170873 | Preoperative TEAS enhances QoR, improves postoperative analgesia and patient's satisfaction, alleviates postoperative side effects, and accelerates discharge after general anesthesia for gynecological laparoscopic surgery. | Evid Based Complement Alternat Med. 2015;2015:324360. doi: 10.1155/2015/324360. Epub 2015 Jun 11. | Side Effects | Clinic |
| 26170873 | Due to side effects of drug therapy, an integrated approach combining pharmacological methods and various complementary analgesic techniques has been recommended in clinical practice. | Evid Based Complement Alternat Med. 2015;2015:324360. doi: 10.1155/2015/324360. Epub 2015 Jun 11. | Side Effects | Clinic |
| 26170873 | Clinical trials have demonstrated that TEAS reduces the consumption of intraoperative anesthetics and general anesthesia related side-effects. | Evid Based Complement Alternat Med. 2015;2015:324360. doi: 10.1155/2015/324360. Epub 2015 Jun 11. | Side Effects | Clinic |
| 26170873 | In addition, TEAS reduces the incidence of general anesthesia induced side effects, such as dizziness, nausea, and vomiting, shortens the duration of PACU stay, and improves patient's satisfaction. | Evid Based Complement Alternat Med. 2015;2015:324360. doi: 10.1155/2015/324360. Epub 2015 Jun 11. | Side Effects Nausea and Vomiting | Clinic |
| 27688791 | However, due to various side effects or safety concerns, such as drug resistance which could affect therapeutic efficacy, antihypertensive medication is unsatisfactory. | Evid Based Complement Alternat Med. 2016;2016:6908710. doi: 10.1155/2016/6908710. Epub 2016 Sep 4. | Side Effects | Clinic |
| 28658163 | High concentration of S100xcexb2 protein is toxic to neurons, and is closely related to POCD. | Medicine (Baltimore). 2017 Jun;96(26):e7375. doi: 10.1097/MD.0000000000007375. | Toxic Side Effects | Clinic |
| 30356057 | No acupuncture or acupressure-related side-effects could be observed. | Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. | Side Effects | Clinic |
| 30356057 | Also, patients should arrive in the post anaesthesia care unit (PACU) the least sedated as possible in order to reduce the period at which they are vulnerable to side effects of anaesthesia. | Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. | Side Effects | Clinic |
| 30356057 | There is substantial evidence provided by systematic reviews for the effectiveness of acupuncture in reducing post-operative pain, cumulative opioid consumption, opioid related side effects as well as pre-operative anxiety. | Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. | Side Effects Anxiety | Clinic |
| 30356057 | Acupuncture-related outcomes included pre-operative anxiety, depth of sedation (bispectral index; BIS), reaction times during emergence, time to extubation, post-operative analgesic consumption and pain intensity, and the occurrence of anaesthesia-related side effects. | Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. | Side Effects Anxiety Sedation | Clinic |
| 30356057 | There were no severe side effects caused by one of the study interventions. | Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. | Side Effects | Clinic |
| 30356057 | The observed number of acupuncture-related side effects -one single event of redness at the acupuncture site- is in accordance with the assumption that acupuncture is a safe intervention. | Sci Rep. 2018 Oct 24;8(1):15734. doi: 10.1038/s41598-018-33459-y. | Side Effects | Clinic |
| 30425466 | In one review of opioid usage among chronic pain patients, the cognitive side effects from opioids were most apparent within several hours of an initial dose, which could explain the increased risk for POD among patients who received opioids intraoperatively. | Clin Interv Aging. 2018 Oct 24;13:2127-2134. doi: 10.2147/CIA.S183698. eCollection 2018. | Side Effects | Clinic |
| 31915045 | The primary end points were postoperative quality of recovery and cognitive functioning, and the secondary endpoint was anesthesia-related side effects, including pain scores, the incidence of nausea and vomiting and use of postoperative pain medications and antiemetics. | Trials. 2020 Jan 8;21(1):43. doi: 10.1186/s13063-019-3892-4. | Cognitive Function Side Effects Nausea and Vomiting | Clinic |
| 33488793 | The results indicated that TEAS could improve postoperative analgesia, reduce postoperative consumption of opioids and alleviate postoperative side effects. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Side Effects | Clinic |
| 33488793 | Due to the advantages of the non-invasive, convenient application and reduced number of side effects of TEAS, it has been increasingly applied in conventional medical settings. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Side Effects | Clinic |
| 33488793 | Although weak opioids (for example, tramadol) and non-steroidal anti-inflammatory drugs cannot inhibit immune function, they are rarely used alone for postoperative pain control, given their weak analgesic effects and side effects. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Analgesic Effect Immunity Side Effects | Clinic |
| 33488793 | TEAS displayed an analgesic role via certain intensity stimulation on specific acupoints, which was characterized by low stimulation, strong operability and few side effects. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Side Effects | Clinic |
| 33488793 | In addition, Liang et al reported that TEAS was an effective adjunct to opioid therapy for moderate and severe cancer-related pain, and could reduce side effects and improve immune function. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Immunity Side Effects | Clinic |
| 33488793 | A previous study indicated that acupuncture at LI-4 was as effective as analgesics in relieving headaches with fewer side effects, which was suggested as an alternative to the non-pharmacological analgesia method. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Side Effects | Clinic |
| 33488793 | To conclude, the present study indicated that TEAS maintained cellular immune function, alleviated postoperative pain and reduced the occurrence of opioid-related side effects, providing a novel insight for selection of postoperative analgesia. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Immunity Side Effects | Clinic |
| 36098938 | CD8+ Txc2xa0cells are cytotoxic Txc2xa0cells, and an elevation in their level indicates that the body is immunocompromised. | Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. | Immunity Toxic Side Effects | Clinic |
| 36749304 | Conventional analgesia medicine could increase the risk of nausea, vomiting and other digestive system side effects, abnormal liver/ renal functions, and inhibit bone formation and healing (Zhao & Davis,). | Brain Behav. 2023 Mar;13(3):e2913. doi: 10.1002/brb3.2913. Epub 2023 Feb 7. | Gastrointestinal Tract Side Effects Nausea and Vomiting Kidney | Clinic |
| 30381011 | Previous studies proved that increased levels of IL-6 may inhibit the cytotoxic activity of NK cells by decreasing the expression of perforin, granzyme B (a serine protease), and tyrosine phosphatase-2 (SHP-2) but do not decrease NK cell numbers. | Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. | Toxic Side Effects | Clinic |
| 30381011 | As an important inflammatory cytokine, TNF-xcexb1 directly influences NK cell activation and cytotoxic effects on tumor cells. | Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. | Toxic Side Effects | Clinic |
| 29773696 | Opioids, in particular morphine, hydromorphine and meperidine, are commonly used in the management of postoperative pain, but have significant side effects, including sedation, nausea, vomiting and itching. | BMJ Open. 2018 May 17;8(5):e018464. doi: 10.1136/bmjopen-2017-018464. | Side Effects Nausea and Vomiting Sedation | Clinic |
| 29773696 | Many people suffer from LBP after back surgery and experience side effects from the opioids used to relieve their pain. | BMJ Open. 2018 May 17;8(5):e018464. doi: 10.1136/bmjopen-2017-018464. | Side Effects | Clinic |
| 29773696 | Therefore, it may be carefully conjectured that EA, a type of acupuncture treatment commonly used by Korean medicine doctors, mayxc2xa0be a good alternative as a non-pharmacological treatment without the risk of opioid-related side effects. | BMJ Open. 2018 May 17;8(5):e018464. doi: 10.1136/bmjopen-2017-018464. | Side Effects | Clinic |
| 34622872 | Opioids could greatly improve the quality of postoperative analgesia and the quality of life after surgery, but it is accompanied with obvious side effects. | Medicine (Baltimore). 2021 Oct 8;100(40):e27461. doi: 10.1097/MD.0000000000027461. | Side Effects | Clinic |
| 34622872 | Patient controlled analgesia, involving opioids such as morphine and fentanyl, as well as anti-inflammatory drugs, could greatly improve the quality of postoperative analgesia and the quality of life after surgery, but it is accompanied with obvious side effects, such as urine retention, vomiting, and allergies. | Medicine (Baltimore). 2021 Oct 8;100(40):e27461. doi: 10.1097/MD.0000000000027461. | Side Effects Nausea and Vomiting | Clinic |
| 34622872 | Our group preliminarily found that plum-blossom needle percussion, one of the acupuncture therapies in traditional Chinese medicine, combined with analgesic could significantly relieve CPSP in NSCLC patients and reduce the side effects of analgesic. | Medicine (Baltimore). 2021 Oct 8;100(40):e27461. doi: 10.1097/MD.0000000000027461. | Analgesic Effect Side Effects | Clinic |
| 34622872 | Opioids, such as Tramadol, could improve the quality of postoperative analgesia and the quality of life after surgery, but it is accompanied with obvious side effects. | Medicine (Baltimore). 2021 Oct 8;100(40):e27461. doi: 10.1097/MD.0000000000027461. | Side Effects | Clinic |
| 20308770 | Acupuncture (ACU) is known to be effective in ischemia treatment, and glutamate (GLU) excitotoxicity is an important factor in neuronal cell death. | Physiol Meas. 2010 May;31(5):633-47. doi: 10.1088/0967-3334/31/5/003. Epub 2010 Mar 22. | Toxic Side Effects | Mechanism |
| 19151301 | Acupuncture stimulation and phototherapy, associated with minimal systemic and local side effects, can enhance the microcirculation and may be a useful supportive treatment for diseases caused by poor peripheral blood flow. | Anesth Analg. 2009 Feb;108(2):635-40. doi: 10.1213/ane.0b013e31819317bc. | Microcirculation Side Effects Blood Flow | Mechanism |
| 20034453 | DISCUSSION: We found that bee venom acupuncture effectively protected dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity, possibly through inhibition of Jun activation. | Neurol Res. 2010 Feb;32 Suppl 1:88-91. doi: 10.1179/016164109X12537002794282. | Toxic Side Effects | Mechanism |
| 19010737 | administration of the alpha(2)-adrenoceptor agonist clonidine has a pronounced analgesic effect, the clinical use of clonidine is limited by its side effects. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Side Effects | Mechanism |
| 19010737 | clonidine produced an analgesic effect similar to that of the high dose of clonidine, but without significant side effects. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Side Effects | Mechanism |
| 19010737 | These data show that DBV-apipuncture significantly enhances clonidine-induced analgesia and suggest that a combination of low dose clonidine with acupuncture therapy represents a novel strategy for pain management that could eliminates clonidine's side effects. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Side Effects | Mechanism |
| 19010737 | The administration of low-dose clonidine in combination with acupuncture produced a potent analgesic effect without significant side effects and thus represents a potential novel strategy for the management of chronic pain. | J Pain. 2009 Mar;10(3):253-63. doi: 10.1016/j.jpain.2008.09.002. Epub 2008 Nov 17. | Analgesic Effect Side Effects | Mechanism |
| 10968647 | Nitric oxide (NO) is an important diffusible neurotransmitter, which also has neurotoxicity when it is overproduced. | Acupunct Electrother Res. 2000;25(2):101-7. doi: 10.3727/036012900816356163. | Toxic Side Effects | Mechanism |
| 19056464 | Acupuncture inhibited decreases in the immunoreactivities of tyrosine hydroxylase (TH) and dopamine transporter (DAT) that occurred as a result of MPTP neurotoxicity. | Neurosci Lett. 2009 Jan 30;450(2):92-6. doi: 10.1016/j.neulet.2008.11.049. Epub 2008 Nov 27. | Immunity Toxic Side Effects | Mechanism |
| 18022144 | Concerns regarding the side effects of pharmacological approaches have recently increased interest in the use of acupuncture for treatment of epilepsy. | Brain Res. 2008 Jan 10;1188:165-72. doi: 10.1016/j.brainres.2007.10.017. Epub 2007 Oct 18. | Side Effects | Mechanism |
| 31192694 | After EA treatment for 3 days, immune response, natural killer (NK) cell toxicity and the expression of cytokines and DREAM/NF-kappaB were assessed. | Acupunct Med. 2019 Oct;37(5):292-300. doi: 10.1136/acupmed-2017-011593. Epub 2019 Jun 13. | Immunity Toxic Side Effects | Mechanism |
| 31192694 | RESULTS: EA treatment, especially at alternating 2/100 Hz frequency, improved spleen and thymus indices, increased lactate dehydrogenase and acid phosphatase levels, promoted concanavalin A- and lipopolysaccharide-induced splenocyte proliferation, increased NK cell toxicity and ameliorated CP-induced immunosuppression in mice. | Acupunct Med. 2019 Oct;37(5):292-300. doi: 10.1136/acupmed-2017-011593. Epub 2019 Jun 13. | Immunity Toxic Side Effects | Mechanism |
| 16376128 | Acupuncture is one of the most effective alternative medical treatments in pain management with the advantages of simple application, low cost and minimal side effects. | Eur J Pain. 2006 Nov;10(8):689-94. doi: 10.1016/j.ejpain.2005.11.001. Epub 2005 Dec 22. | Side Effects | Mechanism |
| 31941349 | However, these drugs produce undesirable side effects, such as headaches, nausea and diarrhoea. | Acupunct Med. 2020 Apr;38(2):101-108. doi: 10.1136/acupmed-2017-011395. Epub 2020 Jan 16. | Side Effects Nausea and Vomiting | Mechanism |
| 31941349 | Acupuncture may serve as an effective alternative treatment for pain relief with few side effects. | Acupunct Med. 2020 Apr;38(2):101-108. doi: 10.1136/acupmed-2017-011395. Epub 2020 Jan 16. | Pain Relief Side Effects | Mechanism |
| 21440609 | Changes of gene expression profiles in the cervical spinal cord by acupuncture in an MPTP-intoxicated mouse model: microarray analysis. | Gene. 2011 Jul 15;481(1):7-16. doi: 10.1016/j.gene.2011.03.006. Epub 2011 Apr 1. | Toxic Side Effects | Mechanism |
| 21440609 | These data suggest that the expression of these exclusively regulated 16 probes (9 genes) may be, at least in part, affected by acupuncture at the acupoints in the cervical spinal cord which can be damaged by MPTP intoxication. | Gene. 2011 Jul 15;481(1):7-16. doi: 10.1016/j.gene.2011.03.006. Epub 2011 Apr 1. | Toxic Side Effects | Mechanism |
| 20034451 | OBJECTIVES: Acupuncture has been known to be effective in ischemia, and glutamate excitotoxicity is an important factor for the neuronal cell death. | Neurol Res. 2010 Feb;32 Suppl 1:79-83. doi: 10.1179/016164109X12537002794200. | Toxic Side Effects | Mechanism |
| 23235115 | These results suggest that the 32 probes (8 annotated genes) which are affected by MPTP and acupuncture may be responsible for exerting the inhibitory effect of acupuncture in the thalamus which can be damaged by MPTP intoxication. | Gene. 2013 Feb 25;515(2):329-38. doi: 10.1016/j.gene.2012.12.002. Epub 2012 Dec 9. | Toxic Side Effects | Mechanism |
| 10794115 | Current methods of treatment are not very effective and often have significant side effects. | Am J Chin Med. 2000;28(1):35-40. doi: 10.1142/S0192415X00000064. | Side Effects | Mechanism |
| 30966771 | We identified that serum- and glucocorticoid-dependent kinase 1 (SGK1) is evidently downregulated in chronic MPTP-intoxication and acupuncture stimulation maintained SGK1 expression at levels similar to the control group. | Am J Chin Med. 2019;47(3):527-539. doi: 10.1142/S0192415X19500277. Epub 2019 Apr 9. | Toxic Side Effects | Mechanism |
| 19607689 | These agents not only inhibit respiratory function and cause constipation, but also induce other significant side effects such as addiction and tolerance, all of which further contribute to a reduced quality of life for cancer patients. | J Exp Clin Cancer Res. 2009 Jul 16;28(1):102. doi: 10.1186/1756-9966-28-102. | Side Effects | Mechanism |
| 19607689 | Some studies have been reported that opioid switching therapy reduced side effects and produced a reduction in pain level. | J Exp Clin Cancer Res. 2009 Jul 16;28(1):102. doi: 10.1186/1756-9966-28-102. | Side Effects | Mechanism |
| 19607689 | But, unfortunately, opioid analgesics often produce poor pain relief against neuropathic cancer pain and also induce adverse side effects such as hormone (e.g., ACTH, cortisol, LH and testosterone) secretion, neurotransmitter (e.g., nicotine, adenosine, GABA and cholecystokinine) release, feeding, gastrointestinal motility, and respiratory activity. | J Exp Clin Cancer Res. 2009 Jul 16;28(1):102. doi: 10.1186/1756-9966-28-102. | Cancer Pain Pain Relief Side Effects | Mechanism |
| 19419550 | Moreover, there are also significant concerns regarding the potential side effects from the long term use of conventional drugs, such as corticosteroids. | J Biomed Sci. 2009 May 6;16(1):46. doi: 10.1186/1423-0127-16-46. | Side Effects | Mechanism |
| 19419550 | It plays a key role in the conversion of testosterone to dihydrotestosterone and in the removal of excess of potentially neurotoxic steroids. | J Biomed Sci. 2009 May 6;16(1):46. doi: 10.1186/1423-0127-16-46. | Toxic Side Effects | Mechanism |
| 22984478 | Major barriers to successful conventional pharmacological treatment include side effects, out-of-pocket expenses, noncompliance of patients and improper dosage/regimen. | PLoS One. 2012;7(9):e44216. doi: 10.1371/journal.pone.0044216. Epub 2012 Sep 12. | Side Effects | Mechanism |
| 25139460 | After electro-acupuncture stimulation at ST36 and BL13, severe lung injury during endotoxic shock was attenuated. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Thus, the regulation of ERK1/2 pathways via electro-acupuncture may be a therapeutic strategy for endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Acute respiratory distress syndrome (ARDS), an indication of acute lung injury (ALI), is highly associated with endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | ALI and ARDS, which represent the severest form of lung injury associated with endotoxic shock, are the leading causes of morbidity and mortality in patients. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | The first-line treatments for patients with endotoxic shock, such as antibiotics, source control, and resuscitation with intravenous fluids to optimize circulation and organ perfusion, are largely limited to persistent hypo-perfusion and end-organ dysfunctions. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects Circulation | Mechanism |
| 25139460 | Investigators have suggested that increased oxidative stress and end-organ damage is related to mortality during endotoxic shock, but the hypotension partly contributing to HO-1 protein and CO has no obvious relation. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Our previous studies also revealed that electro-acupuncture stimulation at ST36 and BL13 could attenuate lung injury during the endotoxic shock, and this effect was due to increased expression of HO-1. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | In particular, we demonstrated that the inhibition of the ERK1/2 pathway, the activation of which contributed to the induction and maintenance of HO-1, in endotoxic shock rats, was possibly involved in exacerbation of lung dysfunction during the endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | However, whether ERK1/2 pathways are involved in mediating the effect of EA on HO-1 in severe lung injury during endotoxic shock has not been fully demonstrated. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Our purpose was to study the molecular mechanisms of EA-mediated up-regulation of HO-1 in lungs of rabbits with endotoxic shock and to correlate it with ERK1/2 activation. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | We used a rabbit model of endotoxic shock, similar to the experimental preparation that we have previously described. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Electro-acupuncture treatment was performed on groups EAM and EAMPD, and group SEAM received acupuncture at a non-acupoint as described above, with no electro-acupuncture treatment on groups C, group D, group PD98059, and group M. Rabbits in group M, SEAM, EAM, EAMPD, and EAMP received 2 mL (5 mg/kg, intravenously) LPS (L2630, Sigma, USA) to replicate the experimental model of endotoxic shock, and those in group C, D, and PD98059 received 2 mL normal saline intravenously as a control. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | The experimental model of endotoxic shock-induced lung injury was defined by the lowered MAP (<75% of the baseline) and oxygenation index (PaO2/FiO2 <300 mmHg). | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | In the present study, we have shown that EA is capable of attenuating LPS-induced lung injury during endotoxic shock and significantly inhibiting LPS-induced up-regulation of MDA and TNF-α, as well as down-regulation of SOD activity. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | These findings show a novel linkage between HO-1 and ERK1/2 signaling pathways in LPS-induced lung injury during endotoxic shock, which expands the understanding of the anti-inflammatory and anti-oxidative activities of EA, and outlines potential molecular mechanisms that explain the protective respiratory effects of EA. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Lung Protection Toxic Side Effects | Mechanism |
| 25139460 | Our previous study showed that the induction of HO-1 by LPS can cause protection of lung, kidney, and liver during endotoxic shock in rats, and up-regulation of HO-1 may become a novel protective strategy for organ injury during endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects Kidney | Mechanism |
| 25139460 | Another previous study also indicated that EA could attenuate lung injury by up-regulating HO-1 during endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Fluorescence quantitative PCR and Western blot analysis showed that HO-1 expression was significantly increased after EA stimulation, indicating that EA stimulation can attenuate lung injury by the up-regulation of HO-1 during endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | In agreement with previous findings, these results suggest that EA stimulation (but not non-acupoint EA stimulation), exerts protective effects on lungs with endotoxic shock by increasing expression of HO-1. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Numerous studies have demonstrated that severe lung injury during endotoxic shock can be caused by multiple factors and that long-lasting inflammatory responses play an important role in the progression of ALI and ARDS. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Our previous study demonstrated that down-regulation of the HO-1 protein by ZnPP-IX, a special inhibitor of HO-1, results in an increase of end-organ dysfunctions in endotoxic shock, while SOD activity was reduced and the MDA content was increased. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | After giving PD98059, accompanied with down-regulation of p-ERK1/2 and HO-1, this effect of EA against oxidative stress was significantly reduced, which shows that a critical mechanism of electro-acupuncture in protecting lungs with endotoxic shock against oxidative stress may be through the effect of the ERK1/2 pathway on up-regulation of HO-1. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Lung Protection Toxic Side Effects | Mechanism |
| 25139460 | To clarify whether the ERK1/2 pathway induced the expression of HO-1 by electro-acupuncture in the lungs of rabbits with endotoxic shock, we used PD98059. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | In summary, this study demonstrated that electro-acupuncture stimulation at acupoints ST36 and BL13, but not EA stimulation at non-acupoints, could up-regulate heme oxygenase-1 in the lungs of rabbits with endotoxic shock and attenuate lung injury during the endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | However, the pathophysiology of lung injury induced by endotoxic shock is a very complicated process, and the exact mechanisms underlying the regulatory role of the ERK1/2 pathway induced by electro-acupuncture on HO-1 expression need further investigation. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Although there is a long way to go before the exact mechanisms of electro-acupuncture on lung injury induced by endotoxic shock can be determined, we believe that the role of signaling pathways induced by electro-acupuncture on expression of HO-1 in the lungs of rabbits with endotoxic shock will draw increasing interest in the future. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | Electro-acupuncture stimulation at ST36 and BL13, in contrast with the non-acupoint, can up-regulate heme oxygenase-1 in the lungs of rabbits with endotoxic shock and attenuate the lung injury during the endotoxic shock. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects | Mechanism |
| 25139460 | In the models of the lung injury induced by endotoxic shock, whether given non-acupoint treatment or given PDTC, histologic examination showed typical pathologic traits of lung injury, such as diffuse edema and severe inflammatory cell (predominantly neutrophils) infiltration in alveoli and interstitium of the lung, hemorrhage, and thickened interlobular septa (M, SEAM and EAMPD), whereas the model with electro-acupuncture treatment showed minimal lung injury, with a mild degree of neutrophil infiltration and thickening of the alveolar walls (EAM). | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Toxic Side Effects Bleeding | Mechanism |
| 26386034 | Nausea and vomiting are major side effects of chemotherapy and can severely impair quality of life. | Acupunct Med. 2016 Apr;34(2):120-6. doi: 10.1136/acupmed-2015-010833. Epub 2015 Sep 17. | Side Effects Nausea and Vomiting | Mechanism |
| 26386034 | Moreover, these drugs frequently cause additional side effects such as headaches, constipation, diarrhoea, asthenia, and somnolence. | Acupunct Med. 2016 Apr;34(2):120-6. doi: 10.1136/acupmed-2015-010833. Epub 2015 Sep 17. | Side Effects | Mechanism |
| 34564665 | Although these treatments are used alone or in combination, there are side effects such as gastrointestinal disorders, exacerbation of heart failure (NSAIDs), hypertension, restriction of use in diabetic patients (corticosteroids), digestive side effects, and renal and nervous system toxicity (Col). | Toxins (Basel). 2021 Sep 16;13(9):661. doi: 10.3390/toxins13090661. | Gastrointestinal Tract Toxic Side Effects Side Effects Kidney | Mechanism |
| 34564665 | Therefore, there is a great demand for a treatment that can quickly relieve pain and reduce inflammation while minimizing the side effects in the treatment of acute gouty arthritis. | Toxins (Basel). 2021 Sep 16;13(9):661. doi: 10.3390/toxins13090661. | Side Effects | Mechanism |
| 34564665 | In our previous experiment, in which BV alone was injected intra-articularly, pain and edema increased temporarily (after 3 h), but returned to normal within 6 h. No significant systemic side effects resulting from BV treatment, such as changes in body weight or increase in mortality, were observed during our experiments. | Toxins (Basel). 2021 Sep 16;13(9):661. doi: 10.3390/toxins13090661. | Side Effects | Mechanism |
| 24828425 | The BBB facilitates selective, diffusion-mediated exchange of membrane-permeant molecules between the circulating blood and the central nervous system, and in this manner protects the brain from extraneous compounds and neurotoxic substances. | PLoS One. 2014 May 14;9(5):e97488. doi: 10.1371/journal.pone.0097488. eCollection 2014. | Toxic Side Effects Circulation | Mechanism |
| 21796340 | In our data, the surprisingly long-lasting Ca2+ oscillations seen after an hour of actuation are testimonies of the power of acupuncture in migrant headache in which healing is now recognized more effective than a chemical drug and yet without side effects. | Pflugers Arch. 2011 Oct;462(4):587-97. doi: 10.1007/s00424-011-0993-7. Epub 2011 Jul 28. | Side Effects | Mechanism |
| 25481535 | Thus, our findings may provide a clinically useful evidence for the application of BVA as an alternative therapeutic option for the management of peripheral neuropathy, a dose-limiting side effect that occurs after an administration of oxaliplatin. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Side Effects | Mechanism |
| 25481535 | The most important side effect of oxaliplatin treatment is a peripheral neuropathy that has unique characteristics and represents a major dose-limiting toxicity. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Toxic Side Effects Side Effects | Mechanism |
| 25481535 | This unpleasant acute neurosensory toxicity with dysesthesia of the distal extremities and perioral region occurs shortly after an infusion in as much as 90% of the patients. | BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471. | Toxic Side Effects | Mechanism |
| 26184310 | The most widely-used models are rat SCI contusion, excitotoxic and hemisection models. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Toxic Side Effects | Mechanism |
| 26184310 | In general, bee venom (BV) contains a number of potential pain-related substances, including melittin, histamine and phospholipase A2, and this mixture of biologically-active substances is able to induce toxic effects, contributing to certain clinical signs or symptoms of envenomation. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Toxic Side Effects | Mechanism |
| 26184310 | Human responses to BV include small edema, redness, extensive local swelling, anaphylaxis, systemic toxic reaction and pain. | Toxins (Basel). 2015 Jul 10;7(7):2571-85. doi: 10.3390/toxins7072571. | Toxic Side Effects Inflammatory Pain | Mechanism |
| 25158599 | The activities of splenic natural killer (NK) cells and cytotoxic T lymphocytes were detected by methyl thiazolyl tetrazolium colorimetric method. | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Toxic Side Effects | Mechanism |
| 25158599 | NK cell and cytotoxic T lymphocyte (CTL) activities assay | BMC Complement Altern Med. 2014 Aug 26;14:316. doi: 10.1186/1472-6882-14-316. | Toxic Side Effects | Mechanism |
| 34659396 | After a cerebral ischemic injury, most grafted cells die as a result of malignant changes in the ischemic focus and the surrounding microenvironment; for example, inflammation or immune response, trophic factor withdrawal, oxidative stress, excitotoxicity, hypoxia, and apoptosis. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Immunity Toxic Side Effects | Mechanism |
| 34659396 | The inflammation leads to the deterioration of the local microenvironment, which is toxic to the host neural cells and is not conducive to the survival of exogenous grafted cells. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Toxic Side Effects | Mechanism |
| 34659396 | Most cell death occurs during the first few days after transplantation as a result of inflammation or immune response, trophic factor withdrawal, oxidative stress, excitotoxicity, hypoxia, and apoptosis. | Neural Plast. 2021 Oct 7;2021:4894881. doi: 10.1155/2021/4894881. eCollection 2021. | Immunity Toxic Side Effects | Mechanism |
| 25302705 | Electro-acupuncture activated some genes involved in apoptosis, NOD-like receptor, cytosolic DNA-sensing pathway, p53, leukocyte transendothelial migration, natural killer cell mediated cytotoxicity, cytokine-cytokine receptor interaction, adipocytokine, and B cell receptor pathways (Figure 4B). | Molecules. 2014 Oct 9;19(10):16158-78. doi: 10.3390/molecules191016158. | Toxic Side Effects | Mechanism |
| 25302705 | Although several common pathways, such as ECM-receptor interaction, MAPK signaling pathway, apoptosis, natural killer cell mediated cytotoxicity, cytokine-cytokine receptor interaction, and leukocyte transendothelial migration pathways were detected in both EA and NA pretreatment groups (Figure 4C,D), most of the genes involved in these pathways were different in EA and NA group; only 27 genes appeared in both EA and NA rats. | Molecules. 2014 Oct 9;19(10):16158-78. doi: 10.3390/molecules191016158. | Toxic Side Effects | Mechanism |
| 25342636 | However, some of these have significant side effects, such as weight gain and increased risk of myocardial infarction. | J Vet Med Sci. 2015 Feb;77(2):167-73. doi: 10.1292/jvms.14-0400. Epub 2014 Oct 22. | Side Effects | Mechanism |
| 25342636 | Acupuncture is thought to be an effective alternative and complementary therapy without side effects. | J Vet Med Sci. 2015 Feb;77(2):167-73. doi: 10.1292/jvms.14-0400. Epub 2014 Oct 22. | Side Effects | Mechanism |
| 26438555 | However, these pharmacological agents have been associated with suboptimal efficacy, poor adherence and side effects, and have many contraindications. | Acupunct Med. 2016 Apr;34(2):127-35. doi: 10.1136/acupmed-2015-010840. Epub 2015 Oct 5. | Side Effects | Mechanism |
| 23173601 | This approach has few side effects and is considered to be a new, effective alternative medicine in Western countries. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Side Effects | Mechanism |
| 26016857 | Due to severe side effects induced by long-term medications for treating chronic neurodegenerative diseases, it is necessary to find non-pharmacological tools to ameliorate these disorders. | J Neuroinflammation. 2015 May 28;12:103. doi: 10.1186/s12974-015-0302-z. | Side Effects | Mechanism |
| 26016857 | It has been found that EA increased ubiquitin C terminal hydrolase-L1 (UCH-L1) and ubiquitin activating enzyme-1 (UBE1) expression in the SN, which led to a reduction of α-syn expression and toxicity. | J Neuroinflammation. 2015 May 28;12:103. doi: 10.1186/s12974-015-0302-z. | Toxic Side Effects | Mechanism |
| 26016857 | Of note, the Nrf2 protection is not restricted to α-syn toxicity. | J Neuroinflammation. 2015 May 28;12:103. doi: 10.1186/s12974-015-0302-z. | Toxic Side Effects | Mechanism |
| 32249904 | However, drug treatment is usually accompanied by many side effects, and with poor long-term efficacy. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects | Mechanism |
| 32249904 | Mongolian medicine annals documentation and modern clinical studies have proven the effectiveness of Mongolian medical warm acupuncture in treating insomnia, and have shown that it is safer than hypnotics as it does not possess any side effects. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects Insomnia | Mechanism |
| 32249904 | However, drug treatment is usually accompanied by many side effects, and with poor long-term efficacy. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects | Mechanism |
| 32249904 | Mongolian medicine annals documentation and modern clinical studies have proven the effectiveness of Mongolian medical warm acupuncture in treating insomnia, and have shown that it is safer than hypnotics as it does not possess any side effects. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects Insomnia | Mechanism |
| 32249904 | Thus, treatment of insomnia using Mongolian medical warm acupuncture has been widely accepted by the patients due to its advantages such as high efficiency, safety, no side effects, simplicity and no drug dependence. | Biosci Rep. 2020 May 29;40(5):BSR20191517. doi: 10.1042/BSR20191517. | Side Effects Insomnia | Mechanism |
| 30089868 | Research has found significant individual differences in the response to such therapies, as well as side effects; therefore, better therapies are needed to treat PTSD. | Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. | Side Effects | Mechanism |
| 30089868 | Acupuncture, a treatment with few side effects, is a major therapy that has been used in East Asia for thousands of years to treat various medical and psychiatric conditions. | Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. | Side Effects | Mechanism |
| 21625423 | Our previous work has shown that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons in the substantia nigra pars compacta from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity in male C57BL/6 mice, a model of PD. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection Toxic Side Effects | Mechanism |
| 21625423 | In the brain MPTP is metabolized to 1-methyl-4-phenylpyridinium (MPP+), the active toxic compound. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 21625423 | The formation and toxic production process of MPP+ are accompanied by an increased production of free radicals, especially superoxide, which is poorly reactive but can be turned into hydrogen peroxide (H2O2). | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 21625423 | 100 Hz EA stimulation protects dopaminergic neurons from MPTP toxicity | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 21625423 | Here we assessed whether EA stimulation could rescue DA neurons in the SNpc from MPTP toxicity by TH immunohistochemistry. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Immunity Toxic Side Effects | Mechanism |
| 21625423 | 100 Hz EA stimulation protects dopaminergic neurons from MPTP toxicity. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 21625423 | In the brain the toxicity of MPTP is due to its toxic form, MPP+, which is selectively toxic to dopaminergic neurons. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 21625423 | Enhanced SOD activity may be neuroprotective since transgenic mice with increased SOD activity are resistant to MPTP injury, while mice with decreased SOD activity are more susceptible to MPTP toxicity. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Neuroprotection Toxic Side Effects | Mechanism |
| 21625423 | Impairment of the GSH system may trigger a cascade of events leading to oxidative stress and destruction of the nigrostriatal pathway as well as render the pathway susceptible to a toxic insult. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 21625423 | In our model the rapid elevation of H2O2 content and GSH-PX activity suggests that the production of ROS is an early event in MPTP toxicity, consistent with the observations in other experiments. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 21625423 | MPP+ activates microglia which exaggerates its toxicity via ROS dependent and independent mechanisms. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Toxic Side Effects | Mechanism |
| 26345700 | Cigarettes contain over 4000 chemical compounds and 400 or more toxic substances including nicotine, tar, acrolein, carbon monoxide, hydrogen cyanide, ammonia, aromatic compounds, arsenic, mercury and chromium. | Acupunct Med. 2016 Apr;34(2):107-13. doi: 10.1136/acupmed-2014-010674. Epub 2015 Sep 7. | Toxic Side Effects | Mechanism |
| 26792101 | More specifically, it can attenuate toxicity of aggregate-prone proteins by activating ALP to clear protein aggregation in several types of NDDs. | Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. | Toxic Side Effects | Mechanism |
| 26792101 | However, since rapamycin influences both upstream and downstream ALP, and broadly affects cell growth and metabolism, rapamycin-based treatments show adverse effects including dyslipidemias, anti-proliferative toxicity and renal dysfunction, which has intrigued intense interest in developing new drugs independent of mTOR or finding new therapeutic targets. | Sci Rep. 2016 Jan 21;6:19714. doi: 10.1038/srep19714. | Toxic Side Effects Adverse Reactions Kidney | Mechanism |
| 28358020 | The common therapies of CAG focus on symptomatic treatment, which are often accompanied by unwanted side effects, incomplete remedy and recurrent episodes. | Sci Rep. 2017 Mar 30;7:45580. doi: 10.1038/srep45580. | Side Effects | Mechanism |
| 23737982 | Electro-Acupuncture Stimulation Improves Spontaneous Locomotor Hyperactivity in MPTP Intoxicated Mice | PLoS One. 2013 May 30;8(5):e64403. doi: 10.1371/journal.pone.0064403. Print 2013. | Toxic Side Effects | Mechanism |
| 23737982 | Our previous work demonstrated that 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI and SANYINJIAO protected the dopaminergic nigrostriatal system of C57BL/6 mice from MPTP toxicity, indicating that acupuncture might be an effective therapy for PD sufferers. | PLoS One. 2013 May 30;8(5):e64403. doi: 10.1371/journal.pone.0064403. Print 2013. | Toxic Side Effects | Mechanism |
| 23737982 | MPTP-lesioned C57BL/6 mice model is widely used to assess novel anti-Parkinsonian therapies, but conflicted results show decreased, increased and neutral phenomenon on locomotor activity, which might be due to different sources of mice or intoxication protocols. | PLoS One. 2013 May 30;8(5):e64403. doi: 10.1371/journal.pone.0064403. Print 2013. | Toxic Side Effects | Mechanism |
| 23737982 | In the brain, it is transformed into the toxic form, MPP+, in non-dopaminergic cells. | PLoS One. 2013 May 30;8(5):e64403. doi: 10.1371/journal.pone.0064403. Print 2013. | Toxic Side Effects | Mechanism |
| 22132113 | Dopamine replacement therapies remain the most effective clinical option for PD patients despite the occasionally severe side effects. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Side Effects | Mechanism |
| 22132113 | Animals and MPTP intoxication | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Toxic Side Effects | Mechanism |
| 22132113 | In the striatum, acupuncture treatment also showed similar protection of dopaminergic fibers against MPTP toxicity (65.61±2.85% vs. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Toxic Side Effects | Mechanism |
| 22132113 | Therefore, the observed increases in relative HVA concentrations and increases in DOPAC/DA and HVA/DA ratios following acupuncture treatment in MPTP-intoxicated mice (Fig. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Toxic Side Effects | Mechanism |
| 22132113 | Consistent with previous reports, MPTP intoxication increased FosB expression in the striatum (Fig. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Toxic Side Effects | Mechanism |
| 22132113 | We also found an increase in the phosphorylation of DARPP-32 after MPTP intoxication (Fig. | PLoS One. 2011;6(11):e27566. doi: 10.1371/journal.pone.0027566. Epub 2011 Nov 22. | Toxic Side Effects | Mechanism |
| 29981376 | These medications have poor efficacy for managing chronic pain and produce adverse side-effects, such as altered mental state, addiction, and life-threatening respiratory depression. | J Pain. 2018 Dec;19(12):1384.e1-1384.e14. doi: 10.1016/j.jpain.2018.05.013. Epub 2018 Jul 4. | Side Effects Depression | Mechanism |
| 24321617 | It has been reported that more than 50% of PD patients who receive chronic l-dopa suffer from this side effect within 5 years. | Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. | Side Effects | Mechanism |
| 24321617 | After the injection with or without acupuncture treatment 10 days more, AIM were scored for test the side effect in addition to motor function improvement by same treatment. | Brain Res. 2014 Jan 28;1544:33-44. doi: 10.1016/j.brainres.2013.11.028. Epub 2013 Dec 7. | Side Effects Motor Function | Mechanism |
| 24524846 | Patients, however, often seek alternatives because of unsatisfactory results or side effects of the conventional approaches. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Side Effects | Mechanism |
| 21872220 | Paclitaxel-induced neurotoxicity has been reported in 60-70% of all treated patients; it mainly presents as sensory neuropathy, with numbness, tingling, and burning pain being the most common complaints. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Toxic Side Effects | Mechanism |
| 21872220 | Thus, lower frequency EA has a potent inhibitory effect on peripheral nerve injury-induced allodynia and hyperalgesia, both metabolic/toxic and traumatic. | Brain Res. 2011 Sep 26;1414:58-65. doi: 10.1016/j.brainres.2011.08.004. Epub 2011 Aug 7. | Toxic Side Effects | Mechanism |
| 29034548 | Current medical treatments for chemotherapy-induced pain (CIP) are either ineffective or have adverse side effects. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Side Effects | Mechanism |
| 29034548 | It represents the chief dose-limiting side effect of the major classes of anti-neoplastic drugs, such as the taxanes, the vinca alkaloids, and the platinum-based drugs, which are used against all of the most common types of cancer. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Side Effects | Mechanism |
| 29034548 | Paclitaxel-induced neurotoxicity typically presents as sensory neuropathy. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Toxic Side Effects | Mechanism |
| 29034548 | However, these approaches have had limited success, and have resulted in a number of side effects. | Eur J Pain. 2018 Apr;22(4):679-690. doi: 10.1002/ejp.1132. Epub 2017 Oct 16. | Side Effects | Mechanism |
| 31600836 | Potential advantages of acupuncture over conventional medical therapy include its prolonged action and few, if any, of side effects. | J Comp Neurol. 2020 Apr;528(6):953-971. doi: 10.1002/cne.24789. Epub 2019 Nov 12. | Side Effects | Mechanism |
| 22524543 | Localized actions could also reduce or eliminate side-effects associated with systemic analgesic drug administration. | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Side Effects | Mechanism |
| 22524543 | Given that PAP works via an A1R-dependent mechanism, PAPupuncture would also bypass side-effects associated with opioid-based analgesics, and hence could provide a novel abuse-resistant way to treat pain. | Mol Pain. 2012 Apr 23;8:28. doi: 10.1186/1744-8069-8-28. | Side Effects | Mechanism |
| 33384922 | Acute ETOH administration studies are scarce despite the potential of ETOH to cause sedation, intoxication and reduced acute functional tolerance. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Toxic Side Effects Sedation | Mechanism |
| 33384922 | Acute ETOH administration studies are scarce despite the potential of ETOH to cause sedation, intoxication and reduced acute functional tolerance. | Integr Med Res. 2021 Jun;10(2):100497. doi: 10.1016/j.imr.2020.100497. Epub 2020 Aug 12. | Toxic Side Effects Sedation | Mechanism |
| 28913350 | Many other studies have demonstrated that acupuncture, which is a safe and effective treatment for stroke, can promote functional recovery in stroke patients without inducing any special side effects. | Biomed Res Int. 2017;2017:3178014. doi: 10.1155/2017/3178014. Epub 2017 Aug 24. | Side Effects | Mechanism |
| 34782576 | A large number of animal experiments have shown that acupuncture at GV20 and GV14 can reduce excitotoxicity, enhance neurogenesis, and promote the release of neurotrophic factors in the brain (e.g., brain-derived neurotrophic factor, nuclear factor kappa B, tropomyosin-related kinase B), which reduces cerebral infarct volume and improves sensorimotor function (Cheng et al., 2014; Kim et al., 2014; Wang et al., 2014; Chang et al., 2018; Park et al., 2019). | Neural Regen Res. 2022 Jun;17(6):1310-1317. doi: 10.4103/1673-5374.327355. | Toxic Side Effects Motor Function | Mechanism |
| 23304201 | Therefore, we believe acupuncture may provide a non-toxic and natural alternative to wound healing. | Evid Based Complement Alternat Med. 2012;2012:464586. doi: 10.1155/2012/464586. Epub 2012 Dec 10. | Toxic Side Effects | Mechanism |
| 34630618 | However, the gastrointestinal adverse effects of lactulose have limited its usage, and it is not recommended for long-term clinical application due to its potential toxicity and the development of drug-resistant strains. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Toxic Side Effects Adverse Reactions | Mechanism |
| 34630618 | Currently, the pathogenesis of HE remains unclear, possible theories include toxication derived from excessive ammonia, γ-aminobutyric acid, manganese ions, and pseudo neurotransmitters, as well as oxidative stress and imbalance of serum amino acid. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Toxic Side Effects | Mechanism |
| 34630618 | Studies on the effects of ammonia toxication on the pathogenesis of HE and neurological damage have made some progress. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Toxic Side Effects | Mechanism |
| 34630618 | IL-6, also known as a proinflammatory factor, can activate microglia and astrocytes and cause neuronal damage and cognitive impairment by inducing the production of neurotoxic transmitters. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Toxic Side Effects | Mechanism |
| 34646326 | Acupuncture is widely used to alleviate visceral pain in China, owing to its ability to provide pain relief with few side effects such as addictiveness. | Evid Based Complement Alternat Med. 2021 Oct 4;2021:5561999. doi: 10.1155/2021/5561999. eCollection 2021. | Visceral Pain Pain Relief Side Effects | Mechanism |
| 31447579 | Due to the side-effects of opioids including addiction, non-opioid treatments are needed for the long-term treatment of chronic pain in SCD. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Side Effects | Mechanism |
| 31447579 | Strategies such as acupuncture have fewer side-effects than pharmacological agents. | J Pain Res. 2019 Aug 1;12:2419-2426. doi: 10.2147/JPR.S210196. eCollection 2019. | Side Effects | Mechanism |
| 26623337 | The advantages of acupuncture are, that it is practical, safe, less expensive, and with fewer side effects when compared with conventional pharmaceutical management of pain. | Open Vet J. 2014;4(1):44-50. Epub 2014 Apr 25. | Side Effects | Mechanism |
| 28672928 | This drug treatment may be accompanied by many side effects. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Side Effects | Mechanism |
| 28672928 | It is widely accepted way of treatment by the patients due to such characteristics as high efficiency, safety, no side effects, simplicity and no drug dependence. | Exp Ther Med. 2017 Jul;14(1):289-297. doi: 10.3892/etm.2017.4452. Epub 2017 May 11. | Side Effects | Mechanism |
| 23970931 | Kainic acid (KA) is a neurotoxin that induces epileptic seizures and excitotoxicity in the hippocampus. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Toxic Side Effects | Mechanism |
| 23970931 | Acupuncture is frequently used as an alternative therapy for epilepsy, and it has been known to protect hippocampal neurons against KA toxicity. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Toxic Side Effects | Mechanism |
| 23970931 | The administration of KA commonly induces epileptic seizures and excitotoxic cell death in the hippocampus, similar to that observed in temporal lobe epilepsy patients. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Toxic Side Effects | Mechanism |
| 23970931 | These results indicate that acupuncture stimulation at HT8 protects hippocampal cells from KA toxicity, but it is still unknown which proteins are related to the action of the acupuncture stimulation. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Toxic Side Effects | Mechanism |
| 23970931 | KA increases ROS production, therefore the upregulation of CRMP-2 may contribute to the suppression of neuronal death from KA toxicity. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Toxic Side Effects | Mechanism |
| 23970931 | We found that acupuncture stimulation at HT8 restored the CRMP-2 level that was decreased by KA administration, which suggests that the restoration of the CRMP-2 level by the acupuncture stimulation contributed to the neuroprotective effect against KA toxicity. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Neuroprotection Toxic Side Effects | Mechanism |
| 23970931 | T-complex protein 1 (TCP-1), a chaperonin family member, that folds protein properly, supports the maintenance of the native forms of cytoskeletal proteins, and the overexpression of all TCP-1 subunits suppressed Neuro2a cell death induced by the cytotoxicity of polyglutamine-expansion proteins. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Toxic Side Effects | Mechanism |
| 23970931 | Taken together, the increases of PURA, PP5, and TCP-1 have the potential to protect hippocampal neurons against KA toxicity. | Evid Based Complement Alternat Med. 2013;2013:436315. doi: 10.1155/2013/436315. Epub 2013 Jul 23. | Toxic Side Effects | Mechanism |
| 26487031 | It has few serious side effects, as long as bead-deposition within the joint is avoided. | Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. | Side Effects | Mechanism |
| 26487031 | The aims of the present study were to describe the technique of implanting 24-karat gold beads around the hip joints of dogs with chronic hip dysplasia, and to record any side effects or complications of such treatment. | Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. | Side Effects | Mechanism |
| 26487031 | There were few long-term side effects of the GBI treatment such as pain, infection and migration of the gold beads, but technical difficulties may occur during positioning of the needles. | Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. | Side Effects | Mechanism |
| 26487031 | The study by Klitsgaard (1996) was not performed as a prospective clinical trial and side effects were not properly evaluated with evaluation forms within 14 days after implantation, and the dogs were not re-examined by a veterinarian at follow-up visits. | Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. | Side Effects | Mechanism |
| 26487031 | With the exception of some aggravation of discomfort during the first two weeks post-implantation, the method has few serious side effects, as long as bead-deposition within the joint is avoided. | Animals (Basel). 2012 Sep 4;2(3):426-36. doi: 10.3390/ani2030426. | Side Effects | Mechanism |
| 31836020 | demonstrated in an animal model of AD that the microglial surface receptor triggering receptor expressed on myeloid cells 2 (TREM-2) plays as a critical role in the protection of neurons by enhancing microglial activities against Aβ depositions and their related toxicity. | J Neuroinflammation. 2019 Dec 13;16(1):264. doi: 10.1186/s12974-019-1665-3. | Toxic Side Effects | Mechanism |
| 25861363 | Thus, many researches have tried to explore the secret of stroke by using gene-chip technology and a lot of biological processes have been found to be related to the pathological injury of ischemic stroke such as inflammation, apoptosis, and excitotoxicity. | Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. | Toxic Side Effects | Mechanism |
| 25861363 | 58 pathways were examined for upregulated mRNAs in this study including the regulation of Staphylococcus aureus infection, phagosome, cell adhesion molecules, cytokine-cytokine receptor interaction, hematopoietic cell lineage, Toll-like receptor signaling pathway, natural killer cell mediated cytotoxicity MAPK signaling pathway, p53 signaling pathway, VEGF signaling pathway, and TGF-beta signaling pathway (see Table 3). | Evid Based Complement Alternat Med. 2015;2015:496932. doi: 10.1155/2015/496932. Epub 2015 Mar 10. | Toxic Side Effects | Mechanism |
| 37066940 | One of the core PTSD symptom is the persistence of memories of the traumatic event that triggered PTSD (i.e., traumatic fear memory) . Recent studies have confirmed that acupuncture can suppress or eliminate fear memory as well as improve sleep architecture, relieve depression, and alleviate spatial learning and memory deficits ; moreover, acupuncture has relatively long-term effects and few side effects. | Technol Health Care. 2023;31(S1):409-421. doi: 10.3233/THC-236035. | Side Effects Learning and Memory Ability Depression | Mechanism |
| 25206697 | Acupuncture is simple to perform, is not toxic, does not have adverse effects, and has been extensively used in the clinic. | Neural Regen Res. 2013 Feb 25;8(6):540-9. doi: 10.3969/j.issn.1673-5374.2013.06.007. | Toxic Side Effects Adverse Reactions | Mechanism |
| 25206697 | Rotenone, an insecticide used for agriculture and fishponds, has strong liposolubility and can traverse the blood-brain barrier, where it exerts a cytotoxic effect. | Neural Regen Res. 2013 Feb 25;8(6):540-9. doi: 10.3969/j.issn.1673-5374.2013.06.007. | Toxic Side Effects | Mechanism |
| 34621320 | Current conventional allopathic treatment options exist for FD, such as H. pylori eradication, proton pump inhibitors (PPIs), and histamine-type-2-receptor antagonists (H2RAs); however, their efficacies are modest at best, and they also result in negative side effects or negative long-term effects to the patient. | Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. | Side Effects | Mechanism |
| 34621320 | For example, H. pylori eradication using antibiotics often produces gastrointestinal side effects such as diarrhea, nausea, taste distortion, stomatitis, and bloating, which reduce the tolerability of treatment and lead to treatment withdrawal; treatments using PPIs have been shown to potentially cause serious long-term adverse effects, such as pneumonia, C. difficile diarrhea, risk of fractures, and hypomagnesemia. | Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. | Side Effects Adverse Reactions Nausea and Vomiting | Mechanism |
| 34621320 | As an alternative form of treatment for FD that does not result in the same long-term side effects and resistance as drugs, acupuncture and/or electroacupuncture (EA) has been used in China for thousands of years to help relieve its various symptoms. | Evid Based Complement Alternat Med. 2021 Sep 14;2021:2771094. doi: 10.1155/2021/2771094. eCollection 2021. | Side Effects | Mechanism |
| 28806763 | However, most of the current anti-obesity drugs and therapies have failed to achieve adequate weight control in patients, due to side effects such as mood changes, suicidal thoughts, and gastrointestinal and cardiovascular complications. | PLoS One. 2017 Aug 14;12(8):e0181948. doi: 10.1371/journal.pone.0181948. eCollection 2017. | Cardiovascular Side Effects Mood | Mechanism |
| 28299842 | Our study supports that harvesting of MSC from the blood of EA-treated human subjects and ex vivo expansion is feasible and may serve as a practical method to harvest cells for autologous cell therapy, free of the risks and discomfort associated with current more invasive and toxic collection methods. | Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613. | Toxic Side Effects | Mechanism |
| 28299842 | chemotherapy, growth factors, or AMD3100) into the bloodstream are plagued by adverse side effects; however use of EA or TENS represents an easy and inexpensive approach to increasing MSC numbers in the peripheral blood to allow MSC harvest and ex vivo expansion. | Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613. | Side Effects | Mechanism |
| 28299842 | Furthermore, harvesting of MSC from the blood of EA-treated human subjects and ex vivo expansion is feasible and may serve as a practical method to harvest cells for autologous cell therapy, free of the risks and discomfort associated with current more invasive and toxic collection methods. | Stem Cells. 2017 May;35(5):1303-1315. doi: 10.1002/stem.2613. | Toxic Side Effects | Mechanism |
| 32021397 | Although pharmacologic treatment is the mainstay of treatment of migraine, many problems, such as medication contraindications, limited response to medications, side effects, and acute medication overuse, are problematic. | J Pain Res. 2020 Jan 13;13:75-86. doi: 10.2147/JPR.S225431. eCollection 2020. | Side Effects | Mechanism |
| 32021397 | Non-pharmacological approaches may potentially offer an alternative for migraineurs who hope to avoid the side effects of pharmacological therapies. | J Pain Res. 2020 Jan 13;13:75-86. doi: 10.2147/JPR.S225431. eCollection 2020. | Side Effects | Mechanism |
| 26064171 | Side effects, such as lethargy and mortality, were observed in one rat in response to oligonol. | Evid Based Complement Alternat Med. 2015;2015:687196. doi: 10.1155/2015/687196. Epub 2015 May 3. | Side Effects | Mechanism |
| 26064171 | We can say that quantum light therapy is a new approach to CP's treatment as an inexpensive and reasonable alternative treatment that has no apparent side effects. | Evid Based Complement Alternat Med. 2015;2015:687196. doi: 10.1155/2015/687196. Epub 2015 May 3. | Side Effects | Mechanism |
| 25206545 | Management of neuropathic pain in patients still constitutes a remarkable therapeutic challenge owing to the modest and variable efficacy as well as the side effects of drugs. | Neural Regen Res. 2013 Sep 5;8(25):2350-9. doi: 10.3969/j.issn.1673-5374.2013.25.006. | Neuropathic Pain Side Effects | Mechanism |
| 31775332 | Its major side effects include chemotherapy-induced peripheral neuropathy (CIPN), which occurred in almost all patients in a dose-dependent manner. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Side Effects | Mechanism |
| 31775332 | Acupuncture is a traditional and effective method for pain relief with few side effects. | Int J Mol Sci. 2019 Nov 25;20(23):5917. doi: 10.3390/ijms20235917. | Pain Relief Side Effects | Mechanism |
| 37096024 | Behavioral interventions are costly and time-consuming, and drugs have inevitable side effects, so they are limited in the clinical treatment of autism. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Side Effects | Mechanism |
| 37096024 | Several clinical studies have confirmed the clinical efficacy of acupuncture for children in treating the diseases mentioned above, especially in the areas of verbal communication, social function and social problems, and no fatal side effects have been reported. | Neuropsychiatr Dis Treat. 2023 Apr 18;19:951-972. doi: 10.2147/NDT.S398321. eCollection 2023. | Side Effects | Mechanism |
| 28600329 | After thyroidectomy, patients often require analgesics such as ketorolac, acetaminophen and morphine, which may aggravate anaesthetic-induced side effects. | Acupunct Med. 2017 Aug;35(4):276-283. doi: 10.1136/acupmed-2016-011177. Epub 2017 Jun 9. | Side Effects | Mechanism |
| 24527041 | However, most antidepressants are not very effective against the wide variety of complex depressive symptoms, and most are associated with serious side effects such as drowsiness, dryness of the mouth, headache, nausea, and sexual dysfunction. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Side Effects Nausea and Vomiting | Mechanism |
| 24527041 | Thus, it is crucial to identify alternative treatments that balance antidepressant therapeutic effects and with minimal side effects. | Evid Based Complement Alternat Med. 2014;2014:216503. doi: 10.1155/2014/216503. Epub 2014 Jan 9. | Side Effects | Mechanism |
| 34405366 | Earlier work has demonstrated that iron, a major component of haemoglobin, which is extremely toxic to nerve cells, is liberated during haematoma formation following ICH and can initiate a Fenton reaction. | J Mol Neurosci. 2022 Jan;72(1):82-96. doi: 10.1007/s12031-021-01890-y. Epub 2021 Aug 17. | Toxic Side Effects | Mechanism |
| 33062027 | However, most of the current antiobesity drugs have failed to achieve adequate weight control in patients due to side effects. | Evid Based Complement Alternat Med. 2020 Sep 24;2020:8764507. doi: 10.1155/2020/8764507. eCollection 2020. | Side Effects | Mechanism |
| 28672900 | However, due to heavy side effects of antidepressants, it is difficult for patients to adhere to the medication for a long duration. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Side Effects | Mechanism |
| 28672900 | While antidepressants and antiepileptics substantially reduce the symptoms, numerous patients cannot tolerate the side effects of their long-term administration. | Exp Ther Med. 2017 Jul;14(1):107-114. doi: 10.3892/etm.2017.4479. Epub 2017 May 19. | Side Effects | Mechanism |
| 37143500 | However, paclitaxel inhibits tumor growth and affects normal cells simultaneously, resulting in damage to mucous membranes, blood vessels, and neurons with a short cell cycle; this causes neuropathic side effects such as pain, tingling, cold sensitivity, and numbness. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Side Effects | Mechanism |
| 37143500 | These side effects are thought to be caused by an immune response following the production of pro-inflammatory mediators and the development of central sensitization and pain behavior caused by paclitaxel administration. | Front Vet Sci. 2023 Apr 18;10:1153903. doi: 10.3389/fvets.2023.1153903. eCollection 2023. | Immunity Side Effects | Mechanism |
| 18830446 | Pharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. | Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. | Side Effects | Mechanism |
| 18830446 | In large animals, it reduces drug undesirable side effects, residues in animal consumption products and treatment costs. | Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. | Side Effects | Mechanism |
| 18830446 | In horses, the side effects are protrusion of the penis and cardiorespiratory depression, leading to hypotension which is the main limitation for its use. | Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. | Side Effects Depression | Mechanism |
| 18830446 | This fact supports the effect of pharmacopuncture to enhance the effect of subclinical doses of drugs, with the advantage of reduction of undesirable side effects. | Evid Based Complement Alternat Med. 2008 Sep;5(3):267-72. doi: 10.1093/ecam/nel096. | Side Effects | Mechanism |
| 26561562 | Diet, hormonal disorders such as hypothyroidism, side effects of medication and, rarely, heavy metal toxicity may induce constipation. | Acupunct Med. 2016 Jun;34(3):194-200. doi: 10.1136/acupmed-2015-010897. Epub 2015 Nov 11. | Toxic Side Effects Side Effects | Mechanism |
| 28837077 | One study showed that manual acupuncture for 15 s at GB34 and LR3 inhibits neurotoxicity and rotational behavior in the PD rat model 2 weeks after intrastriatal injection of 6-hydroxydopamine. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Toxic Side Effects | Mechanism |
| 28837077 | 1-Methyl-4-phenylpyridinium (MPP+) is the toxic metabolite of MPTP. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Toxic Side Effects | Mechanism |
| 28837077 | In mice overexpressing Bcl-2, MPTP toxicity is attenuated via the enhancement of antioxidant activity and the suppression of apoptosis. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Toxic Side Effects | Mechanism |
| 28837077 | Besides effecting changes in signaling pathways, accumulating evidence suggests that the neuroprotective effects of acupuncture also involve endogenous biological mediators, such as the neurotrophin (NT) family of proteins, specifically, BDNF. | Int J Mol Sci. 2017 Aug 24;18(9):1846. doi: 10.3390/ijms18091846. | Neuroprotection Side Effects | Mechanism |
| 30127121 | In addition to primary injury, secondary injury (including ischemia and edema around the hematoma, toxic effects of hemoglobin metabolites, inflammatory responses, and neural cell apoptosis) contributes to the overall functional loss and determines the long-term outcome (Lu et al., 2014; Xu et al., 2017). | Neural Regen Res. 2018 Sep;13(9):1602-1608. doi: 10.4103/1673-5374.237123. | Toxic Side Effects | Mechanism |
| 20981331 | The aim of this study was to investigate whether AC administration would improve these side effects of CC on the endometrium histology, endometrium receptivity cytokine, and the serum estradiol(E2) and progesterone(P) in CC-induced rat model and to provide evidence for the use of AC in reproduction. | Evid Based Complement Alternat Med. 2011;2011:606514. doi: 10.1155/2011/606514. Epub 2010 Sep 30. | Side Effects | Mechanism |
| 20981331 | Under the present high dose in our experiment, the rat model with high-serum E2, thin and impaired endometrium confirmed the side effects of CC and resulted in abnormal endometrial receptivity which may cause the failure of approximately two-thirds of implantations. | Evid Based Complement Alternat Med. 2011;2011:606514. doi: 10.1155/2011/606514. Epub 2010 Sep 30. | Side Effects | Mechanism |
| 35069759 | However, these drugs are accompanied by some side effects, such as headache, dizziness, fatigue, loss of appetite, nausea, vomiting, and drowsiness, and approximately 18% of women do not respond these. | Evid Based Complement Alternat Med. 2022 Jan 13;2022:4571981. doi: 10.1155/2022/4571981. eCollection 2022. | Side Effects Nausea and Vomiting | Mechanism |
| 35722406 | Acupuncture is an economical TCM therapy with few side effects; it has been used for thousands of years in Asia for numerous diseases, including the rehabilitation stage following stroke. | Ann Transl Med. 2022 May;10(10):540. doi: 10.21037/atm-22-2068. | Side Effects | Mechanism |
| 25983633 | These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Additionally, gene expression in thalamic regions damaged by MPTP intoxication may be affected, at least in part, by acupuncture at specific acupoints. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Thus, we investigated changes in gene expression profiles in the SN region in a relatively chronic Parkinsonism model and identified the genes related to the inhibitory effect of acupuncture on alterations in gene expression induced by MPTP intoxication. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Immunohistochemical analyses using Western blots confirmed that the decrease in TH levels in the striatal and SNpc regions induced by MPTP intoxication was significantly inhibited by acupuncture at acupoints (MPTP-A) but not at non-acupoints (MPTP-NA; Figure 2). | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Immunity Toxic Side Effects | Mechanism |
| 25983633 | These results confirm that acupuncture stimulation suppresses the pathological change in TH levels induced by MPTP intoxication in the striatal and SNpc regions, of the mice in our study. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Changes in gene expression in the SN region following chronic MPTP intoxication | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Compared to the control, 244 up-regulated (Table S1) and 255 down-regulated (Table S2) DEGs were identified in the SN region following chronic MPTP intoxication. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Up-down-regulated genes following MPTP intoxication and acupuncture | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | In the current study, Slc6a13 was up-regulated in the MPTP group compared to the control group; therefore this may be the underlying cause of neuronal intoxication. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Serping1 is up-regulated in the microglial pathway upon stimulation by interferon-gamma (IFN-gamma; or lethal lipopolysaccharide-induced endotoxic shock. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Proline itself has been postulated to be neurotoxic when its extracellular concentration is increased in the brain. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | These results indicate that acupuncture may suppress the Slc6a4 overexpression caused by MPTP intoxication. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Moreover, testosterone has been reported to be neurotoxic to dopaminergic neurons. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Thus, olfactory receptor-related genes may be related to the pathological mechanisms of MPTP neurotoxicity. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Pathway analyses for the 22 probes that were up-regulated by MPTP intoxication (vs. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | MPTP), as well as for the 17 probes down-regulated by MPTP intoxication (vs. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Acupuncture stimulation attenuates the reduction of TH induced by 6-OHDA intoxication and MPTP (; ) in nigrostriatal dopaminergic neurons. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 25983633 | Therefore, the effect of MPTP intoxication on gene expression in the SN region may be ameliorated by acupuncture at acupoints. | Genet Mol Biol. 2015 Mar;38(1):115-27. doi: 10.1590/S1415-475738120140137. Epub 2014 Mar 17. | Toxic Side Effects | Mechanism |
| 30069225 | Although Intranasal corticosteroids and antihistamines exhibit clinical efficacy for the treatment of AR, they cause inevitable side effects such as hormone resistance, drowsiness, and sedation. | Evid Based Complement Alternat Med. 2018 Jul 5;2018:7629239. doi: 10.1155/2018/7629239. eCollection 2018. | Side Effects Sedation | Mechanism |
| 35416841 | Therefore, the search for an effective, nontoxic treatment with minimal side effects has received close attention from the scientific community. | Arq Neuropsiquiatr. 2022 Mar;80(3):289-295. doi: 10.1590/0004-282X-ANP-2021-0149. | Toxic Side Effects Side Effects | Mechanism |
| 35251208 | Because a fundamental and effective treatment method is unavailable for the complex mechanism underlying PTSD, anti-depressants are used most frequently; these therapeutic agents have limitations related to their serious side effects and the potential for treatment refusal. | Evid Based Complement Alternat Med. 2022 Feb 23;2022:4430484. doi: 10.1155/2022/4430484. eCollection 2022. | Side Effects | Mechanism |
| 35178106 | However, conventional chemotherapy drugs have high systemic side effects and poor local selectivity, and the survival rates of HCC patients remain poor. | Evid Based Complement Alternat Med. 2022 Feb 8;2022:5572869. doi: 10.1155/2022/5572869. eCollection 2022. | Side Effects | Mechanism |
| 28860844 | It measures the efficiency of swimming to a hidden, submerged platform from four different locations in a circular tank filled with opaque and nontoxic water (22°C±1°C). | J Pain Res. 2017 Aug 8;10:1887-1897. doi: 10.2147/JPR.S140840. eCollection 2017. | Toxic Side Effects Circulation | Mechanism |
| 31312613 | Compared with the conventional drug delivery system, TDDS has advantages in improving drug efficacy, reducing drug dosages, and side effects. | Front Oncol. 2019 Jul 2;9:576. doi: 10.3389/fonc.2019.00576. eCollection 2019. | Side Effects | Mechanism |
| 31312613 | Cytotoxic chemotherapy is the major treatment choice used for triple-negative breast cancer. | Front Oncol. 2019 Jul 2;9:576. doi: 10.3389/fonc.2019.00576. eCollection 2019. | Toxic Side Effects | Mechanism |
| 31312613 | Besides, the elevated TUNEL apoptosis index in paclitaxel combined acupuncture group further suggested that acupuncture intervention may lead to increased paclitaxel cytotoxicity most likely by increasing the intratumoral drug concentration. | Front Oncol. 2019 Jul 2;9:576. doi: 10.3389/fonc.2019.00576. eCollection 2019. | Toxic Side Effects | Mechanism |
| 27630692 | The main functions of acupuncture treatment are improvement of blood circulation, increasing of cerebral blood flow, improvement of hemorheological properties, regulation of metabolism and neurotransmitter balance after ischemia, reduction of oxidative free radical damage, reduction of lipid peroxidation, excitatory amino acid release and toxicity, maintenance of membrane equilibrium, prevention of calcium overload in cells, regulation of gene expression, and inhibition of neuronal apoptosis (Liu et al., 2004; Dong et al., 2009). | Neural Regen Res. 2016 Jul;11(7):1099-101. doi: 10.4103/1673-5374.187042. | Toxic Side Effects Circulation Blood Flow | Mechanism |
| 30106051 | Acupuncture is different from drug therapy and achieves a better effect with minimal side effects during treatment of multiple chronic conditions (Luo and Du, 2014). | Neural Regen Res. 2018 Aug;13(8):1390-1395. doi: 10.4103/1673-5374.235292. | Side Effects | Mechanism |
| 30431067 | It has been hypothesized that the mitochondria exert neurotoxicity by allowing the influx of Aβ to cells via the Tom40 import pore. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Toxic Side Effects | Mechanism |
| 35928244 | reported that acupuncture at GB34 reduced CCl4-induced liver toxicity and protected liver function. | Evid Based Complement Alternat Med. 2022 Jun 29;2022:3294273. doi: 10.1155/2022/3294273. eCollection 2022. | Toxic Side Effects | Mechanism |
| 31785199 | Currently, antidepressant drugs have variable efficacy and can have serious side effects. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Side Effects | Mechanism |
| 31785199 | Acupuncture is a traditional Chinese medicine that is effective in some cases of clinical depression and has few side effects. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Side Effects Depression | Mechanism |
| 31785199 | A high concentration of NO in cells can further release Glu through NO-cGMP pathway, resulting in a neuronal cytotoxic effect, reducing synaptic plasticity of neurons. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Toxic Side Effects | Mechanism |
| 31785199 | When levels of the NMDA receptor subunits NR1, NR2A, and NR2B are increased, they can cause neuro-excitatory toxicity and neuropsychiatric symptoms. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Toxic Side Effects | Mechanism |
| 31785199 | The NO derived from iNOS and nNOS) has neurotoxic effects. | Med Sci Monit. 2019 Nov 30;25:9112-9122. doi: 10.12659/MSM.917593. | Toxic Side Effects | Mechanism |
| 23573158 | Moxibustion has been adopted as an analgesic method for thousands of years in China and other AsiaN countries and is still frequently used in the present clinical practice because of its advantages of safety, effectiveness, and no side effects. | Evid Based Complement Alternat Med. 2013;2013:920675. doi: 10.1155/2013/920675. Epub 2013 Mar 16. | Side Effects | Mechanism |
| 26998388 | Intravenous Toxicity Study of Water-soluble Ginseng Pharmacopuncture in SD Rats | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | This study was performed to investigate the single-dose intravenous toxicity of water-soluble ginseng pharmacopuncture (WSGP) in Sprague-Dawley (SD) rats. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | The rat's general conditions and body weights, the results of their hematological and biochemistry tests, and their necropsy and histopathological findings were investigated to identify the toxicological effect of WSGP injected intravenously. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | No deaths were found in this single-dose toxicity test on the intravenous injection of WSGP, and no significant changes in the rat's general conditions and body weights, the results on their hematological and biochemistry test, and their necropsy findings were observed during the test. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | In this research, a toxicological test on water-soluble ginseng pharmacopuncture (WSGP) was carried out. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | On the day of injection (day 0), the general symptoms (toxicological effects, manifestation time, recovery time, etc. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | WSGP was made, and toxicity test was performed at 0.1-, 0.5-, and 1.0-mL doses of WSGP. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | Tissue from a liver in the intravenous single-dose toxicity study on the injection of WSGP in SD rats. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | Tissue from the brain in the intravenous single-dose toxicity study of WSGP in SD rats. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 26998388 | Tissue from a kidney in the intravenous single-dose toxicity study of WSGP in SD rats. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects Kidney | Mechanism |
| 26998388 | Tissue from spinal nerves in the intravenous single-dose toxicity study of WSGP in SD rats. | J Pharmacopuncture. 2015 Dec;18(4):38-44. doi: 10.3831/KPI.2015.18.036. | Toxic Side Effects | Mechanism |
| 23970928 | Therefore, an understanding of the pathogenesis of CD intestinal fibrosis and the discovery of effective prophylactic measures with fewer side effects are urgently needed in this field. | Evid Based Complement Alternat Med. 2013;2013:198282. doi: 10.1155/2013/198282. Epub 2013 Jul 22. | Side Effects | Mechanism |
| 32967614 | Pharmacological therapy is effective in improving the clinical symptoms of DPN, but it is also associated with considerable side effects in a long-term drug treatment. | J Physiol Sci. 2020 Sep 23;70(1):45. doi: 10.1186/s12576-020-00769-8. | Side Effects | Mechanism |
| 31045558 | As a common means of PTSD, acupuncture has high efficiency, long duration of action, and low side effects, it can effectively reduce anxiety-like behaviors and improve the impaired learning-memory ability in PTSD rats . | Technol Health Care. 2019;27(S1):425-443. doi: 10.3233/THC-199038. | Side Effects Learning and Memory Ability Anxiety | Mechanism |
| 31871478 | However, the dose of levodopa must be increased as treatment duration is extended, and more than 50% of patients with PD taking levodopa suffer from side effects, such as levodopa-induced dyskinesia (LID). | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Side Effects | Mechanism |
| 31871478 | It also enhances the availability of synaptic dopamine, decreases the effective dose of levodopa, and relieves side effects. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Side Effects | Mechanism |
| 31871478 | A histological analysis was performed to determine the effect of KD5040 on MPTP neurotoxicity. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Toxic Side Effects | Mechanism |
| 31871478 | High-dose KD5040 also led to cytotoxicity ( in the Supplementary Materials). | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Toxic Side Effects | Mechanism |
| 31871478 | Additionally, acupuncture treatment increased the efficiency of levodopa at doses lower than those normally considered effective. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Side Effects | Mechanism |
| 31871478 | Acupuncture treatment also reduced the side effects of levodopa. | Evid Based Complement Alternat Med. 2019 Nov 21;2019:3612587. doi: 10.1155/2019/3612587. eCollection 2019. | Side Effects | Mechanism |
| 33791033 | Pharmacopunture also reduces undesirable side effects, sediments in animal products for consumption, and treatment costs, thus enabling successive applications during the breeding season. | Anim Reprod. 2020 Nov 25;17(4):e20200554. doi: 10.1590/1984-3143-AR2020-0554. | Side Effects | Mechanism |
| 30899176 | It is simple in equipment, simple in operation, effectively avoids trauma to the body, with a good therapeutic effect and no toxic or side effects. | Saudi J Biol Sci. 2019 Mar;26(3):589-594. doi: 10.1016/j.sjbs.2018.12.007. Epub 2018 Dec 6. | Toxic Side Effects Side Effects | Mechanism |
| 30899176 | used laser acupotomy to treat temporomandibular disorders (TMD), and also found that laser irradiation can relieve pain, relax muscles and promote blood circulation, and can regulate metabolism, change histopathological conditions and promote the recovery of tissue health, and it is safe and efficient without side effects. | Saudi J Biol Sci. 2019 Mar;26(3):589-594. doi: 10.1016/j.sjbs.2018.12.007. Epub 2018 Dec 6. | Side Effects Circulation | Mechanism |
| 27852302 | reported the same effects in an endotoxic shock-related lung injury model in rabbits. | BMC Complement Altern Med. 2016 Nov 16;16(1):470. doi: 10.1186/s12906-016-1457-6. | Toxic Side Effects | Mechanism |
| 34646336 | Metabolic cardiomyopathy (MC) is characterized by the accumulation of TG and lipotoxic damage in the myocardium, which is a new cause of heart failure in obese patients. | Comput Math Methods Med. 2021 Oct 4;2021:6730274. doi: 10.1155/2021/6730274. eCollection 2021. | Toxic Side Effects Myocardium | Mechanism |
| 22110373 | Although N-methyl-d-aspartate (NMDA) receptors antagonists are highly effective in reducing neuropathic pain, these agents cause severe side effects at therapeutic doses, which limit their clinical uses. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain Side Effects | Mechanism |
| 22110373 | Human case series have demonstrated substantial symptom reduction without added side effects. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Side Effects | Mechanism |
| 22110373 | Although NMDA antagonists are highly effective in reducing neuropathic pain, these agents cause side effects at therapeutic doses including hallucination, dysphoria, and impairment of cognitive function. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Neuropathic Pain Cognitive Function Side Effects | Mechanism |
| 22110373 | Therefore, the development of methods with a reduced side effect profile is greatly needed. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Side Effects | Mechanism |
| 22110373 | From these findings, the combination of EA with low doses of an NMDA receptor antagonist may provide improved strategies for pain management, thus potentially decreasing drug side effects in patients with persistent pain. | Exp Neurobiol. 2011 Sep;20(3):144-52. doi: 10.5607/en.2011.20.3.144. Epub 2011 Sep 20. | Side Effects | Mechanism |
| 30106055 | Cytotoxicity, oxidative stress, and especially, inflammation play key roles in secondary injury after ICH (Keep et al., 2012; Zhou et al., 2014). | Neural Regen Res. 2018 Aug;13(8):1425-1432. doi: 10.4103/1673-5374.235298. | Toxic Side Effects | Mechanism |
| 21799685 | Frequently used medications such as non-steroidal anti-inflammatory drugs have serious and even dangerous side effects, including bleeding and perforated ulcers. | Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. | Side Effects Bleeding | Mechanism |
| 21799685 | Cyclooxygenase-2 inhibitors can reduce the gastrointestinal side effects, but these carry an elevated risk for cardiovascular disease, and some have now been withdrawn from the market. | Evid Based Complement Alternat Med. 2011;2011:619650. doi: 10.1093/ecam/neq016. Epub 2011 Jan 9. | Cardiovascular Side Effects | Mechanism |
| 37179843 | Unfortunately, there are no completely effective therapeutic approaches for depression to date; the currently available antidepressant strategies such as medications, psychotherapies, or others have limited efficacy and significant side effects during the treatment period. | Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. | Side Effects Depression | Mechanism |
| 37179843 | Current available therapeutic approaches such as medications and psychotherapies have limited efficacy and obvious side effects. | Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. | Side Effects | Mechanism |
| 37179843 | Acupuncture has been identified as a safe and effective alternative therapy for depression with fewer side effects. | Neural Plast. 2023 May 2;2023:1474841. doi: 10.1155/2023/1474841. eCollection 2023. | Side Effects Depression | Mechanism |
| 27381504 | Duloxetine also decreases FM-related pain symptoms but may have potentially serious side effects. | Acupunct Med. 2017 Mar;35(1):59-68. doi: 10.1136/acupmed-2015-010986. Epub 2016 Jul 5. | Side Effects | Mechanism |
| 37384285 | RTX, a TRPV1 agonist, leads to a sustained influx of sodium and calcium through the TRPV1 channel and leads to a loss of TRPV1-expressing DRG neurons or their fiber terminals through channel desensitization and calcium-induced cytotoxicity. | Front Neurol. 2023 Jun 13;14:1168012. doi: 10.3389/fneur.2023.1168012. eCollection 2023. | Toxic Side Effects | Mechanism |
| 26064176 | Active microglia exerted a cytotoxic effect due to the secretion of ROS and the proinflammatory cytokines including TNF-α and IL-1β and was responsible for painful behavior induced by inflammation and injury. | Evid Based Complement Alternat Med. 2015;2015:848603. doi: 10.1155/2015/848603. Epub 2015 Apr 29. | Toxic Side Effects | Mechanism |
| 26279808 | Investigations of AQP4-deficient (AQP4-/-) mice have revealed that AQP4 promotes cytotoxic edema but reduces vasogenic edema after brain injury. | J Korean Neurosurg Soc. 2015 Jul;58(1):14-21. doi: 10.3340/jkns.2015.58.1.14. Epub 2015 Jul 31. | Toxic Side Effects | Mechanism |
| 26279808 | In AQP4-/- mice, acute brain injury after focal cerebral ischemia is attenuated as a result of reduced cytotoxic edema. | J Korean Neurosurg Soc. 2015 Jul;58(1):14-21. doi: 10.3340/jkns.2015.58.1.14. Epub 2015 Jul 31. | Toxic Side Effects | Mechanism |
| 25206919 | Modern studies have demonstrated that acupuncture and moxibustion at Baihui and Shenshu regulate acetylcholinesterase activity, elevate cortical excitability and cerebral blood flow, improve cerebral circulation, protect against free radical oxidation and neurotoxic injury, suppress inflammation and cell apoptosis, improve learning and memory functions, and effectively treat senile dementia (Mao et al., 2012; Luo et al., 2013). | Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148. | Toxic Side Effects Learning and Memory Ability Circulation Blood Flow | Mechanism |
| 34804173 | Caspase-9 is involved in the intrinsic mitochondria pathway, which is initiated by various stimuli such as hypoxia and cytotoxic agents, cellular distress, and DNA damage inside the cell. | Evid Based Complement Alternat Med. 2021 Nov 12;2021:1418616. doi: 10.1155/2021/1418616. eCollection 2021. | Toxic Side Effects | Mechanism |
| 25810743 | Acupuncture is one of the most promising supplementary medical treatments because of easy application, low cost, and minimum side effects. | Evid Based Complement Alternat Med. 2015;2015:393569. doi: 10.1155/2015/393569. Epub 2015 Feb 25. | Side Effects | Mechanism |
| 38164490 | The use of ACE in musculoskeletal pain has been explored to replace agents such as NSAIDs and acetaminophen, which have severe side effects, including weight gain, gastrointestinal symptoms, and dizziness. | Iran J Basic Med Sci. 2024;27(1):66-73. doi: 10.22038/IJBMS.2023.71431.15534. | Side Effects | Mechanism |
| 25206816 | This study showed that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression was increased in the rat frontal lobe and ventral tegmental area of heroin relapse rats, and indicated that chronic toxic effects of heroin caused nerve cell injury, led to compensatory protection of the body, increased endogenous brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression, and repaired injured nerve cells. | Neural Regen Res. 2014 Feb 1;9(3):301-7. doi: 10.4103/1673-5374.128228. | Toxic Side Effects | Mechanism |
| 34393735 | However, antidepressant therapy may cause unwanted side effects, and its effects are slow. | Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. | Side Effects | Mechanism |
| 34393735 | However, antidepressant therapy may cause unwanted side effects, and its effects are slow. | Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. | Side Effects | Mechanism |
| 29623933 | Using electroacupuncture and moxibustion to treat peripheral nerve injury is highly efficient with low side effects. | Neural Regen Res. 2018 Mar;13(3):477-483. doi: 10.4103/1673-5374.228731. | Side Effects | Mechanism |
| 29623933 | Although exogenous NGF has been utilized in the clinic to improve nerve injury, the optimal administration route, dosage, and side effects of NGF still need to be clearly described. | Neural Regen Res. 2018 Mar;13(3):477-483. doi: 10.4103/1673-5374.228731. | Side Effects | Mechanism |
| 29849693 | Given the limited effects of standard treatments on DN progression, several new agents such as empagliflozin have been developed to more effectively reduce proteinuria; yet, these agents are also associated with side effects such as urinary tract infection, hypovolemia, and ketoacidosis. | Evid Based Complement Alternat Med. 2018 Apr 23;2018:1913691. doi: 10.1155/2018/1913691. eCollection 2018. | Side Effects | Mechanism |
| 28386185 | Modern research shows that cerebral ischemia, reperfusion injury appears as calcium overload, brain edema, excitotoxicity, and oxidative stress. | Saudi J Biol Sci. 2017 Mar;24(3):595-602. doi: 10.1016/j.sjbs.2017.01.031. Epub 2017 Jan 23. | Toxic Side Effects | Mechanism |
| 28386185 | This phenomenon was induced by glutamate excitotoxicity, which aggravated the injury of ischemia reperfusion. | Saudi J Biol Sci. 2017 Mar;24(3):595-602. doi: 10.1016/j.sjbs.2017.01.031. Epub 2017 Jan 23. | Toxic Side Effects | Mechanism |
| 28386185 | Sodium and water retention were caused by cytotoxic cerebral edema. | Saudi J Biol Sci. 2017 Mar;24(3):595-602. doi: 10.1016/j.sjbs.2017.01.031. Epub 2017 Jan 23. | Toxic Side Effects | Mechanism |
| 30028333 | The pathophysiology of SCI involves the primary injury and the subsequent secondary injury, which results from a progressive local cascade of tissue destruction, including the change in the microenvironment of the injured spinal cord (ischemia of the microcirculation, edema, inflammation, glutamatergic excitotoxicity) and apoptosis. | Neural Regen Res. 2018 Jul;13(7):1241-1246. doi: 10.4103/1673-5374.235062. | Microcirculation Toxic Side Effects | Mechanism |
| 30105072 | Amyloid-β can have direct toxic effect on nerve cells and can also activate central nervous system microglia to release inflammatory mediators which trigger nerve cell injury signaling pathways, leading to neuronal damage. | Evid Based Complement Alternat Med. 2018 Jul 12;2018:8296824. doi: 10.1155/2018/8296824. eCollection 2018. | Toxic Side Effects | Mechanism |
| 28761425 | The pathological and physiological mechanism underlying cerebral ischemia/reperfusion injury is now thought to be associated with an injury cascade that includes several sub-mechanisms, such as excitatory toxicity (Lewerenz and Maher, 2015), peripheral depolarization, inflammation (Cuenca-López et al., 2010; Mozaffarian et al., 2015), lipid peroxide reaction caused by oxidative stress (Ying and Xiong, 2010), and programmed cell death. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Toxic Side Effects | Mechanism |
| 29946236 | Nowadays, all available antidepressants whose action is based on the monoamine hypothesis of depression have many side effects and limited efficacies, which limits their usages and results in poor compliance. | Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. | Side Effects Depression | Mechanism |
| 25624811 | It is virtually absent from intact brain tissue, but its expression increases strongly after trauma, excitotoxic lesioning1 and ischemia-reperfusion injury. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Toxic Side Effects | Mechanism |
| 25624811 | Transforming growth factor-beta 1 induction has been associated with several anti-inflammatory effects including decreased neuronal susceptibility to glutamate excitotoxicity, macrophage deactivation and astrocytic brain-derived neurotrophic factor induction. | Neural Regen Res. 2012 Aug 25;7(24):1859-65. doi: 10.3969/j.issn.1673-5374.2012.24.003. | Toxic Side Effects | Mechanism |
| 26392912 | Single-dose Intramuscular-injection Toxicology Test of Water-soluble Carthami-flos and Cervi cornu parvum Pharmacopuncture in a Rat Model | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | The aim of the study is to investigate both the single-dose intramuscular injection toxicity and the approximate lethal dose of water-soluble Carthami-flos and Cervi cornu parvum pharmacopuncture (WCFC) in male and female Sprague-Dawley (SD) rats. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | according to the Good Laboratory Practice (GLP) regulation and the toxicity test guidelines of the Ministry of Food and Drug Safety (MFDS) after approval of the Institutional Animal Care and Use Committee. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | The results of this single-dose toxicity study show that WCFC is safe, its lethal doses in male and female SD rats being estimated to be higher than 0.5 mL/animal. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | Water-soluble Carthami-flos and Cervi cornu parvum pharmacopuncture (WCFC) is CFC emulsified in water and is developed to enhance the effect of CFC and to reduce the side effects caused by oil-based pharmacopuncture. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Side Effects | Mechanism |
| 26392912 | On the bases of single intramuscular- dose toxicity tests and single intravenous-dose toxicity tests, WCF was reported to be safe when injected into the body intramuscularly or intravenously. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | Now, a toxicity study of WCFC is necessary. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | For that reason, we performed a single-dose intramuscular-injection toxicity study to evaluate the safety of WCFC and to estimate its approximate lethal dose. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | The tests were performed according to Good Laboratory Practice (GLP) regulation and toxicity test guidelines of the Ministry of Food and Drug Safety (MFDS). | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | General clinical sign, such as types of toxicity, onset time, recovery time, etc., and deaths were observed 30 minutes, 1, 2, 4, and 6 hours after the first injection on the day of the first injection (day 0). | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | No toxicological importance was found because the slight changes in the AST level in the female rat in the low dosage (0.125 mL/animal) group were sporadically observed with no dose dependence (AST in female group: 96.2 ± 23.7 U/L in the low dose (0.125 mL/animal) group vs. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | These residues in the muscle or subcutaneous tissue can cause inflammation and produce side effects. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Side Effects | Mechanism |
| 26392912 | Thus, we hypothesize that WCFC can reduce the side effects of CFC that may occur in the clinic because WCFC emulsifies CFC in water and can be absorbed easily. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Side Effects | Mechanism |
| 26392912 | No mortalities or abnormal findings in body weights, clinical symptoms, and hematology and serum chemistry data were observed in this single-dose intramuscular-injection toxicology test. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | However, we speculate that those abnormalities have no toxicological meaning because they were spontaneous and sporadic and showed no dose dependence. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | Therefore, based on the results of this toxicity study, we conclude that WCFC is safe. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | However, additional safety studies or toxicological tests, such as 4-week, repeated toxicity tests and so on, as well as efficacy studies, are needed. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 26392912 | The results of this single-dose toxicity study show that WCFC is safe because the lethal doses of WCFC in male and female SD rats were estimated to be higher than 0.5 mL/animal. | J Pharmacopuncture. 2015 Sep;18(3):42-8. doi: 10.3831/KPI.2015.18.023. | Toxic Side Effects | Mechanism |
| 31835339 | Due to its advantages of low cost, few side effects, and simple operation, the role of acupuncture in disease prevention and treatment has recently attracted attention, and a large body of evidence has shown that acupuncture can induce pathophysiological consequences and alleviate the symptoms of diseases in multiple organs. | Metabolites. 2019 Dec 9;9(12):299. doi: 10.3390/metabo9120299. | Side Effects | Mechanism |
| 31835339 | Given its safety and few side effects, this major TCM has been widely used to treat various diseases and symptoms, especially chronic metabolic illness. | Metabolites. 2019 Dec 9;9(12):299. doi: 10.3390/metabo9120299. | Side Effects | Mechanism |
| 31835339 | However, in some NAFLD patients, the accumulation of lipids is not toxic to liver cells, a paradoxical effect that is believed to be related to the type of lipid itself. | Metabolites. 2019 Dec 9;9(12):299. doi: 10.3390/metabo9120299. | Toxic Side Effects | Mechanism |
| 31835339 | Second, although acupuncture treatment has few side effects, since this was the first instance of observing the effects of needling the three acupoints ST36, KI1, and CV4 in mice with NAFLD, and since this treatment was administered daily for only two weeks, we cannot confirm that no side effects would be noted with this approach over a long period of time. | Metabolites. 2019 Dec 9;9(12):299. doi: 10.3390/metabo9120299. | Side Effects | Mechanism |
| 36116306 | Electroacupuncture is a safe, effective method with few side effects. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Side Effects | Mechanism |
| 36116306 | Electro-acupuncture is a safe, effective method with few side effects. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Side Effects | Mechanism |
| 36116306 | Today, modern medicine often uses analgesics, anti-inflammatory, anti-edematous drugs with the advantage of fast-acting, long-lasting but with many side effects. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Side Effects | Mechanism |
| 36116306 | Regarding the unwanted effects of the treatment regimen, we noted that electroacupuncture is a safe, effective method with few side effects. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Side Effects | Mechanism |
| 36116306 | This result is similar to the study of Cao Thi Huyen Trang and Bui Tien Hung when the authors showed that the use of electroacupuncture in patients after arthroscopic surgery for anterior cruciate ligament rupture did not cause any side effects. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Side Effects | Mechanism |
| 36116306 | Electro-acupuncture is a safe, effective method with few side effects. | Int J Surg Case Rep. 2022 Oct;99:107600. doi: 10.1016/j.ijscr.2022.107600. Epub 2022 Sep 7. | Side Effects | Mechanism |
| 27843474 | In clinic, numerous randomized controlled trials have demonstrated that acupuncture therapy in migraine can reduce frequencies of attacks for prophylactic intervention with few side effects, and it can instantly attenuate pain in the acute phase. | Evid Based Complement Alternat Med. 2016;2016:1846296. doi: 10.1155/2016/1846296. Epub 2016 Oct 24. | Side Effects | Mechanism |