- The advantages of acupuncture anesthesia in clinical practice
In clinical practice, acupuncture anesthesia presents a multitude of advantages, pivotal among these being Body System Protection. This technique supports the body's natural defenses, reducing the physiological stress often associated with surgical procedures. By modulating the body's response to pain, acupuncture anesthesia allows for a lower Dosage of Medication, significantly reducing the potential for drug-related side effects. Furthermore, this approach plays a crucial role in Emotion Regulation, helping patients maintain a calm and stable emotional state, which is essential for a positive surgical outcome. The impact of acupuncture on the nervous system not only aids in Pain Relief but also promotes Enhanced Recovery After Surgery. Patients tend to experience faster recuperation times, attributed to the holistic nature of this method. Additionally, acupuncture anesthesia is associated with a Lower Incidence of Side Effects compared to conventional anesthetics. Its ability to modulate and balance the body's responses makes it an invaluable tool in the realm of modern medicine, offering a safer, more patient-centered approach to pain management and recovery.
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Lower Incidence of Side Effects
- Toxic Side Effects
- Acupuncture anesthesia can help reduce the toxic side effects of certain medications used in surgery, minimizing harm to the patient's body.
- Hypothermia
- Acupuncture anesthesia can aid in maintaining normal body temperature during surgery, reducing the risk of hypothermia.
- Stress Response
- Acupuncture anesthesia can mitigate the body's stress response to surgery, promoting a more relaxed and stable physiological state.
- Nausea and Vomiting
- Acupuncture anesthesia has antiemetic properties, effectively preventing postoperative nausea and vomiting.
- Adverse Reactions
- Acupuncture anesthesia can minimize adverse reactions to anesthesia drugs, enhancing patient safety during surgical procedures.
- Side Effects
- Acupuncture anesthesia's minimal side effects make it a safer alternative to traditional anesthesia methods.
- Insomnia
- Acupuncture anesthesia can improve sleep quality by reducing postoperative pain and discomfort.
- Urinary Retention
- Acupuncture anesthesia can help prevent urinary retention, ensuring proper urinary function post-surgery.
- Sleep Quality
- Acupuncture anesthesia contributes to better sleep quality by alleviating pain and promoting relaxation.
- Urinary Incontinence
- Acupuncture anesthesia can address urinary incontinence issues, improving bladder control post-surgery.
Acupuncture anesthesia for Lower Incidence of Side Effects-Stress Response
| PMID | Evidence | Source | Keyword | Type |
|---|---|---|---|---|
| 33788440 | The summarized findings showed that acupuncture anesthesia has a better analgesic effect in thyroid surgery, which can reduce the occurrence of stress reactions, adverse reactions and complications, and is conducive to postoperative recovery. | Zhen Ci Yan Jiu. 2021 Feb 25;46(2):168-71. doi: 10.13702/j.1000-0607.200283. | Analgesic Effect Adverse Reactions Stress Response | Review |
| 38191169 | CONCLUSIONS: The combined anesthesia of acupuncture-pharmacotherapy in pulmonary resection surgery could improve anesthesia and analgesia effectiveness, reduce anesthesia drug usage, regulate immune responses, suppress stress reactions, and the safety is satisfactory. | Zhongguo Zhen Jiu. 2023 Jan 12;44(1):109-122. doi: 10.13703/j.0255-2930.20221008-0005. | Immunity Stress Response | Review |
| 30416533 | Accordingly, it seems reasonable to propose that acupuncture attenuates relapse to drug-seeking behavior through inhibition of stress response. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Stress Response | Review |
| 30416533 | In the present review, we focused on acupuncture's effectiveness in suppressing relapse to drug-seeking behavior by modulating brain stress response systems. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Stress Response | Review |
| 30416533 | Effect of Acupuncture on Stress Response | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Stress Response | Review |
| 30416533 | In addition, studies have demonstrated that acupuncture reduces stress response by the following mechanisms: (1) inhibition of the sympathoadrenal medullary system in rats exposed to immobilization stress, (2) inhibition of HPA system in maternal separation rats, and (3) suppression of HPA system in ethanol-withdrawn rats, respectively. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Stress Response | Review |
| 30416533 | Based on CRF-noradrenergic interaction in the amygdala, it was suggested that acupuncture may reduce ethanol withdrawal dysphoric symptoms by modulating the stress response system. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Stress Response | Review |
| 30416533 | Thus, acupuncture inhibition of drug-seeking behavior might result from modulation of stress response system in the amygdala through activation of β-endorphinergic neurons in the arcuate nucleus of the hypothalamus. | Evid Based Complement Alternat Med. 2018 Oct 17;2018:5367864. doi: 10.1155/2018/5367864. eCollection 2018. | Stress Response | Review |
| 30424749 | The mechanisms of acupuncture for vascular dementia are multiple such as anti-apoptosis, antioxidative stress reaction, and metabolism enhancing of glucose and oxygen. | BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z. | Stress Response | Review |
| 30855351 | The acupuncture group showed that the changes in the mean arterial pressure and heart rate were significantly less than those in the control group, and the increases in plasma adrenaline and cortisol before and after lobectomy in the acupuncture group were also less than those in the control group, indicating that acupuncture could reduce the stress response. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Heart Rate Stress Response | Review |
| 30855351 | TEAS experiments (TEAS at Yuyao [EX-HN4], Taiyang [EX-HN5], Hegu [LI4], and Fengchi [GB20] acupoints) compared the perioperative stress response of craniotomy, and confirmed that the heart rate and arterial pressure during the operation of electroacupuncture group were more stable than those of the control group. | Chin Med J (Engl). 2019 Mar 20;132(6):707-715. doi: 10.1097/CM9.0000000000000123. | Heart Rate Stress Response | Review |
| 30984420 | We have reviewed the research from 2000 to 2017 studying the mechanism of acupuncture in treating hypertension and have found that RAAS, vascular endothelium, oxidative stress response, neuroendocrine system, genes, metabolism, and other factors are all involved in the antihypertensive mechanism of acupuncture. | Int J Hypertens. 2019 Mar 7;2019:8676490. doi: 10.1155/2019/8676490. eCollection 2019. | Stress Response | Review |
| 33633868 | It has been confirmed that acupuncture at specific acupoints specifically activates stress reaction neurons (SRNs) in PVN and influences the CNS through the HPA axis. | Transl Neurosci. 2021 Feb 16;12(1):96-102. doi: 10.1515/tnsci-2021-0011. eCollection 2021 Jan 1. | Stress Response | Review |
| 33917977 | The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Neuroprotection Stress Response | Review |
| 33917977 | In these studies, the effects and/or underlying mechanisms of acupuncture on anxiety and fear behaviors, depression behavior, sleep disturbance, cognitive symptoms (especially spatial learning and memory), and stress responses in PTSD animal models have been reported (Figure 3 and Table 2). | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Insomnia Stress Response Learning and Memory Ability Anxiety Depression | Review |
| 33917977 | The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Neuroprotection Stress Response | Review |
| 33917977 | As other aspects of the stress response, acupuncture downregulated nNOS expression in the locus coeruleus and hippocampus, which are associated with stress responses, upregulation of hippocampal mineralocorticoid receptor expression, and downregulation of hippocampal glucocorticoid receptor expression. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Stress Response | Review |
| 33917977 | These results suggest the role of acupuncture in the regulation of stress responses by neuroendocrine regulation. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Stress Response | Review |
| 33917977 | The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. | J Clin Med. 2021 Apr 8;10(8):1575. doi: 10.3390/jcm10081575. | Neuroprotection Stress Response | Review |
| 34437474 | demonstrated that acupuncture could promote the central secretion of opioid peptides in patients with headaches in the recovery phase of ischemic stroke to reduce the pain stress response and the secretion of pain-related factors, thus playing a therapeutic role. | Vet Sci. 2021 Jul 30;8(8):149. doi: 10.3390/vetsci8080149. | Stress Response | Review |
| 34671411 | The underlying molecular mechanisms of acupuncture involved in the present review for hypertension are summarized as follows: (1) inhibition of inflammatory factors including tumor necrosis factor-α (TNF-α), interleukin-6, and C-reactive protein, as well as inflammation-related genes, through toll-like receptor 4 in the PVN; (2) reduction of oxidative stress reactions by inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity by downregulation of p38 mitogen-activated protein kinases and extracellular signal-regulated protein kinase 1/2; (3) inhibition of AngII activity in the plasma, myocardium, thoracic aorta, rostral ventrolateral medulla, kidney, etc. | Evid Based Complement Alternat Med. 2021 Oct 11;2021:8171636. doi: 10.1155/2021/8171636. eCollection 2021. | Stress Response Kidney Myocardium | Review |
| 36864974 | We studied the mechanism of acupuncture for hypertension from 2002 to 2021 and discovered that the brain function, vascular endothelium, oxidative stress response, neuroendocrine system, renin-angiotensin-aldosterone system (RAAS), genes, metabolism, and other elements all play a role in the antihypertensive mechanism of acupuncture. | Cardiovasc Diagn Ther. 2023 Feb 28;13(1):67-82. doi: 10.21037/cdt-22-480. Epub 2022 Dec 15. | Stress Response | Review |
| 36864974 | Acupuncture, for instance, may enhance NO to control endothelial dysfunction, as well as downregulate AT1R affirmation and enhance AT2R interpretation to influence RAAS by controlling C-reactive protein (CRP); or acupuncture may prevent the oxidative stress of reactive oxygen species (ROS) by constraining Ang II, resulting in an antihypertensive effect. | Cardiovasc Diagn Ther. 2023 Feb 28;13(1):67-82. doi: 10.21037/cdt-22-480. Epub 2022 Dec 15. | Stress Response | Review |
| 37046882 | In particular, the fact that auricular acupuncture stimulates the vagus nerve through ABVN means that this treatment can be regarded as a type of noninvasive vagus nerve stimulation; furthermore, it can have a beneficial effect on the stress response control. | Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. | Stress Response | Review |
| 37046882 | Three of the included studies found a significant reduction in salivary cortisol levels after auricular acupuncture in individuals with suicidal ideation, which is considered the biological basis for the improvement of the stress response. | Healthcare (Basel). 2023 Mar 27;11(7):955. doi: 10.3390/healthcare11070955. | Stress Response | Review |
| 37200784 | Moreover, acupuncture's effect on PTSD may be mediated by the promotion of neuroprotection, neurogenesis, and synaptic plasticity in multiple brain areas, the regulation of stress responses in the neuroendocrine system, and signaling pathway involvement. | Front Behav Neurosci. 2023 May 2;17:1163718. doi: 10.3389/fnbeh.2023.1163718. eCollection 2023. | Neuroprotection Stress Response | Review |
| 37396891 | In addition, studies have reported that acupuncture combined with sedation was effective in suppressing stress responses and stabilizing hemodynamics in patients, thus less affecting vital signs than using sedatives alone. | Front Med (Lausanne). 2023 Jun 16;10:1189429. doi: 10.3389/fmed.2023.1189429. eCollection 2023. | Hemodynamics Stress Response Sedation | Review |
| 37397275 | Perioperative acupuncture aims to reduce stress response, pain, postoperative complications, and mortality, and plays a significant role in the postoperative recovery of patients. | J Pain Res. 2023 Jun 27;16:2189-2204. doi: 10.2147/JPR.S415998. eCollection 2023. | Stress Response Postoperative Complications | Review |
| 37795371 | This study shows that the regulation of the HPA-axis trough EA, treating acupoints SP6, KI9, LR14 and BL23, is one of the explanatory mechanisms by which acupuncture modulates the stress response. | Front Endocrinol (Lausanne). 2023 Sep 18;14:1236370. doi: 10.3389/fendo.2023.1236370. eCollection 2023. | Stress Response | Review |
| 21442823 | [Effect of acupuncture-assisted anesthesia on stress response during laparoscopic cholecystectomy in aged patients]. | Zhongguo Zhen Jiu. 2011 Feb;31(2):155-7. | Stress Response | Clinic |
| 21442823 | OBJECTIVE: To compare the difference between transcutaneous electrical acupoint stimulation (TEAS) assisted general anesthesia and simple general anesthesia on stress response during laparoscopic cholecystectomy (LC) in aged patients. | Zhongguo Zhen Jiu. 2011 Feb;31(2):155-7. | Stress Response | Clinic |
| 21442823 | CONCLUSION: Acupuncture-assisted anesthesia profit to maintain the hemodynamic stable and reduce the stress response during LC in aged patients. | Zhongguo Zhen Jiu. 2011 Feb;31(2):155-7. | Stress Response | Clinic |
| 22073889 | CONCLUSION: Acupuncture-assisted anesthesia can decrease the dosage of general anesthetics, and effectively restrain cardiovascular stress reaction during trachea extubation in pulmonery lobectomy patients. | Zhen Ci Yan Jiu. 2011 Oct;36(5):361-5. | Cardiovascular Stress Response | Clinic |
| 22073889 | CONCLUSION: Acupuncture-assisted anesthesia can decrease the dosage of general anesthetics, and effectively restrain cardiovascular stress reaction during trachea extubation in pulmonery lobectomy patients. | Zhen Ci Yan Jiu. 2011 Oct;36(5):361-5. | Cardiovascular Stress Response | Clinic |
| 8280549 | We have studied the effects of electroacupuncture at classical acupuncture points, applied before and during surgery in patients undergoing hysterectomy, on postoperative pain and metabolic stress responses in a prospective, randomized and patient-blinded manner. | Br J Anaesth. 1993 Dec;71(6):835-8. doi: 10.1093/bja/71.6.835. | Stress Response | Clinic |
| 8280549 | There were no significant differences between the two groups in postoperative analgesic requirements, pain-rating or metabolic stress responses. | Br J Anaesth. 1993 Dec;71(6):835-8. doi: 10.1093/bja/71.6.835. | Stress Response | Clinic |
| 29391879 | Overall, combined acupuncture and general anesthesia in elderly gastric cancer patients receiving subtotal gastrectomy showed more stable hemodynamics and fewer stress responses during surgery. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Hemodynamics Stress Response | Clinic |
| 29391879 | The stress responses caused by general anesthesia can increase the secretion of catechol and epinephrine, thus leading to suppression of immune functions of the T lymphocytes. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Immunity Stress Response | Clinic |
| 29391879 | However, combined acupuncture and general anesthesia can control the stress responses and partially protect immune function. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Immunity Stress Response | Clinic |
| 29391879 | Systematic and bidirectional regulation on multiple organs can be realized via electro-acupuncture stimulation, which can not only mobilize pain suppression but also suppress physiological disorders and reduce stress responses to inhibit the inflammatory responses and maintain stable circulation. | Oncol Lett. 2018 Jan;15(1):189-194. doi: 10.3892/ol.2017.7262. Epub 2017 Oct 24. | Stress Response Circulation | Clinic |
| 35647012 | It can stabilize the internal environment of patients, alleviate postoperative stress response and inflammatory response, and regulate the body immune function. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Immunity Stress Response | Clinic |
| 35647012 | During this period, severe hemodynamic abnormalities, severe stress response, obvious postoperative anesthesia side effects and high incidence of adverse reactions easily occur. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Side Effects Adverse Reactions Stress Response | Clinic |
| 35647012 | When patients undergo surgical trauma, the release of inflammatory mediators will lead to increased nervous system sensitivity, increased pain, significant stress response, and the appearance of agitation. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Stress Response | Clinic |
| 35647012 | In addition, stimulant actions such as tracheal intubation and extubation performed on patients during the surgery will lead to the aggravation of stress response of the body and trigger agitation reaction. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Stress Response | Clinic |
| 35647012 | In summary, acupuncture anesthesia combined with general anesthesia has good anesthesia effect in elderly patients undergoing gastrointestinal tumor resection, which can stabilize the body environment of patients, alleviate postoperative stress response and inflammatory response, and regulate body immune function. | Front Surg. 2022 May 12;9:901638. doi: 10.3389/fsurg.2022.901638. eCollection 2022. | Immunity Stress Response Acupuncture Anesthesia Effect | Clinic |
| 36034956 | Therefore, strengthening perioperative analgesia management, reducing pain degree, alleviating patients' physical and mental stress response, and promoting early postoperative functional exercise are of great importance for postoperative rehabilitation and prognosis. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Stress Response | Clinic |
| 36034956 | Studies have reported that the pain caused by surgical injurious stimulation and the disease itself can cause neuroendocrine stress response, resulting in excessive metabolism such as elevated blood glucose and water and sodium retention, which hinder postoperative recovery of patients. | Evid Based Complement Alternat Med. 2022 Aug 17;2022:3130956. doi: 10.1155/2022/3130956. eCollection 2022. | Stress Response | Clinic |
| 24137250 | Surgery and the resultant stress response lead to a suppression of immune function. | Exp Ther Med. 2013 Sep;6(3):699-702. doi: 10.3892/etm.2013.1225. Epub 2013 Jul 16. | Immunity Stress Response | Clinic |
| 32062864 | There is accumulating evidence indicating that TEAS may decrease the stress response during extubation, enhance the anesthetic effect, improve the quality of postoperative recovery, yield a cardioprotective effect, and reduce opioid consumption and related PONV risks.3, 6, 7, 8, 9, 10 | Thorac Cancer. 2020 Apr;11(4):928-934. doi: 10.1111/1759-7714.13343. Epub 2020 Feb 16. | Stress Response | Clinic |
| 33488793 | Recently, there has been increasing interest in the influence of perioperative immune function secondary to the surgical stress response, anesthesia and postoperative acute pain. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Immunity Stress Response | Clinic |
| 33488793 | Postoperative pain may trigger a strong stress response, stimulate the release of inflammatory factors and inhibit immune function. | Exp Ther Med. 2021 Mar;21(3):184. doi: 10.3892/etm.2021.9615. Epub 2021 Jan 7. | Immunity Stress Response | Clinic |
| 36098938 | However, preoperative anxiety, intraoperative pneumoperitoneum, and postoperative pain-induced stress reactions can suppress gastrointestinal and immune functions, seriously affecting postoperative recovery. | Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. | Immunity Stress Response Anxiety | Clinic |
| 36098938 | Our study showed that TEAS effectively suppressed the stress response during pneumoperitoneum establishment and extubation, keeping MAPs and HRs stable. | Pain Ther. 2022 Dec;11(4):1327-1339. doi: 10.1007/s40122-022-00429-2. Epub 2022 Sep 13. | Stress Response | Clinic |
| 30381011 | The traditional thoracotomy causes more trauma and can lead to a strong stress reaction and severe fluctuation of hemodynamics intraoperatively. | Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. | Hemodynamics Stress Response | Clinic |
| 30381011 | This phenomenon is primarily related to tumor cell dissemination, perioperative stress response, and the inhibition of cellular immune function. | Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. | Immunity Stress Response | Clinic |
| 30381011 | Nevertheless, the MAPs and HRs after induction were higher than the baseline values in group sham TEAS, demonstrating that TEAS was beneficial to maintaining hemodynamic stability and reducing the stress response. | Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. | Stress Response | Clinic |
| 30381011 | The TEAS was also beneficial for maintaining hemodynamic stability, reducing the stress response, decreasing the interoperative consumption of propofol and remifentanil, and decreasing the length of the hospital stay. | Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806477. doi: 10.1177/1533033818806477. | Stress Response | Clinic |
| 15633814 | These results suggest that decreased c-fos expression in hypothalamic and LC neurons, among stress-related areas, may reflect the integrative action of acupuncture in stress response. | Am J Chin Med. 2004;32(5):795-806. doi: 10.1142/S0192415X04002405. | Stress Response | Mechanism |
| 19733189 | Acupuncture with the manipulation of the needles according to traditional Chinese medicine or with the electrical stimulation applied on needles inserted into the acupoints (referred as electro-acupuncture, EA) may modulate stress response, mood, learning and memory process. | Physiol Behav. 2009 Dec 7;98(5):537-42. doi: 10.1016/j.physbeh.2009.08.011. Epub 2009 Sep 3. | Stress Response Learning and Memory Ability Mood | Mechanism |
| 29330044 | Sound stimuli such as fireworks, firearms, and claps of thunder have been used as a stress reactivity model for dogs. | Physiol Behav. 2018 Mar 15;186:37-44. doi: 10.1016/j.physbeh.2018.01.006. Epub 2018 Jan 9. | Stress Response | Mechanism |
| 7819540 | It is suggested that the anterior pituitary cells that respond to stress are also activated by acupuncture or painful stimulation. | Neuroreport. 1994 Aug 15;5(13):1649-52. doi: 10.1097/00001756-199408150-00027. | Stress Response | Mechanism |
| 23386059 | The interplay of stress hormones of the hypothalamus-pituitary-adrenal axis (HPA) and the sympathetic nervous system (SNS) is critical in the stress response. | J Endocrinol. 2013 Mar 15;217(1):95-104. doi: 10.1530/JOE-12-0404. Print 2013 Apr. | Stress Response | Mechanism |
| 22156045 | While many factors contribute to the chronic stress response, the sympathetic peptide, neuropeptide Y (NPY), has been shown to be elevated in chronic stress and is hypothesized to contribute to the physiological stress response. | Exp Biol Med (Maywood). 2012 Jan;237(1):18-23. doi: 10.1258/ebm.2011.011224. Epub 2011 Dec 7. | Stress Response | Mechanism |
| 28546432 | Regulation of the endoplasmic reticulum stress response and neuroprotective effects of acupuncture on brain injury caused by heroin addiction. | Acupunct Med. 2017 Oct;35(5):366-373. doi: 10.1136/acupmed-2016-011220. Epub 2017 May 25. | Neuroprotection Stress Response | Mechanism |
| 36156370 | HT7 stimulation ameliorated the acute caffeine exposure-induced increase in the expression of BiP, an endoplasmic reticulum stress response protein, in the rat medial septum. | Biomed Pharmacother. 2022 Nov;155:113724. doi: 10.1016/j.biopha.2022.113724. Epub 2022 Sep 23. | Stress Response | Mechanism |
| 36156370 | These findings suggest that HT7 stimulation improves wake time and REM sleep dysfunction by regulating the BDNF-mediated endoplasmic reticulum stress response in the medial septum. | Biomed Pharmacother. 2022 Nov;155:113724. doi: 10.1016/j.biopha.2022.113724. Epub 2022 Sep 23. | Stress Response | Mechanism |
| 38189854 | MPTP intraperitoneal injection induced an increase in inflammatory factors in PD mice and promoted the oxidative stress response, and the inflammatory response was alleviated after electroacupuncture treatment. | J Mol Neurosci. 2024 Jan 8;74(1):5. doi: 10.1007/s12031-023-02186-z. | Stress Response | Mechanism |
| 25139460 | MAPK have an important role in cellular processes, such as stress responses, apoptosis, and immune defense. | Med Sci Monit. 2014 Aug 16;20:1452-60. doi: 10.12659/MSM.890736. | Immunity Stress Response | Mechanism |
| 25282142 | Our results indicated that the background effect of acupuncture at GV14, BL12 and BL13 modulated biological regulatory processes, including protein stability, stress responses and metabolic systems, such as energy metabolism and responses to steroid hormone stimuli, which could maintain or promote physiological homeostasis in the body. | BMC Complement Altern Med. 2014 Oct 5;14:375. doi: 10.1186/1472-6882-14-375. | Stress Response | Mechanism |
| 29550760 | Compared with the Normal group, modelled group rats had significantly decreased food intake with reduced activity, were stress unresponsive, and had limb hemiplegia and signs of other neurological deficits, which demonstrated that the modelling had been successful. | Acupunct Med. 2018 Aug;36(4):247-253. doi: 10.1136/acupmed-2017-011472. Epub 2018 Mar 17. | Stress Response | Mechanism |
| 37435647 | Corticotropin-releasing hormone (CRH) is a key regulatory peptide that mediates the hypothalamus-autonomic nervous system pathway to various stress responses and plays an important role in stress responses. | J Neurophysiol. 2023 Aug 1;130(2):380-391. doi: 10.1152/jn.00156.2023. Epub 2023 Jul 12. | Stress Response | Mechanism |
| 37435647 | Therefore, CRH is an important participant in stress response, integrating peripheral and visceral stress-related information to guide neuroendocrine autonomy and behavioral adaptation through the endocrine and neural transmission of PVN. | J Neurophysiol. 2023 Aug 1;130(2):380-391. doi: 10.1152/jn.00156.2023. Epub 2023 Jul 12. | Endocrinology Stress Response | Mechanism |
| 37435647 | In addition, CRH is a key regulatory peptide mediating the hypothalamic-autonomic nervous system pathway to various stress responses and plays an important role in the stress response. | J Neurophysiol. 2023 Aug 1;130(2):380-391. doi: 10.1152/jn.00156.2023. Epub 2023 Jul 12. | Stress Response | Mechanism |
| 23173601 | We can only infer that the possible reason for an OXA decrease in the model group is that the laparotomy is a traumatic injury to rats and induces a stress response, which causes exhaustion of OXA in the CNS. | BMC Complement Altern Med. 2012 Nov 22;12:225. doi: 10.1186/1472-6882-12-225. | Stress Response | Mechanism |
| 30089868 | Acupuncture modulates stress response by the mTOR signaling pathway in a rat post-traumatic stress disorder model | Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. | Stress Response | Mechanism |
| 30089868 | Forced maintenance of high corticosterone levels is associated with the stress response and subsequent depression- and anxiety-like behaviors in patients with PTSD. | Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. | Stress Response Anxiety Depression | Mechanism |
| 30089868 | Therefore, the modulatory action of acupuncture on the HPA axis could participate in inhibiting stress responses induced by SPS. | Sci Rep. 2018 Aug 8;8(1):11864. doi: 10.1038/s41598-018-30337-5. | Stress Response | Mechanism |
| 21625423 | found that 100 Hz EA normalized the elevation of glyoxalase II, which plays a pro-survival role in the metabolic stress response through detoxifying methylglyoxal in MPTP mice, and they assumed that it could be due to the relief of oxidative stress in the striatum by increasing antioxidant enzyme activities, thereby precluding methylglyoxal accumulation. | PLoS One. 2011;6(5):e19790. doi: 10.1371/journal.pone.0019790. Epub 2011 May 23. | Stress Response | Mechanism |
| 24524846 | Several genes, such as fos, nr4a1, dusp1, and nfkbia, which increased after acupuncture needling and are part of the immediate early genes, respond to various external stimulations and trigger the expression of stress response genes. | J Pain. 2014 May;15(5):535-49. doi: 10.1016/j.jpain.2014.01.498. Epub 2014 Feb 10. | Stress Response | Mechanism |
| 30906419 | In addition, coexpressed DEGs networks indicated that Cd4 and Il-33 might mediate the cascade of inflammation and oxidative stress responses, which could serve as a potential target of acupuncture treatment. | Evid Based Complement Alternat Med. 2019 Feb 18;2019:9541079. doi: 10.1155/2019/9541079. eCollection 2019. | Stress Response | Mechanism |
| 30906419 | For instance, MAPK signaling pathway, JNK or ERK cascade, and glutathione metabolism are acknowledged as the fundamental processes mediating oxidative stress responses, while NF-kappa B and Toll-like receptor signaling pathways, and interleukin-1 could be the direct mediator of cellular inflammation or promotor of oxidative stress. | Evid Based Complement Alternat Med. 2019 Feb 18;2019:9541079. doi: 10.1155/2019/9541079. eCollection 2019. | Stress Response | Mechanism |
| 34630618 | The P38MAPK signaling pathway is an important member of the mitogen-activated protein kinase family, which can be activated by a variety of stress stimuli including reactive oxygen species and plays an important role in processes such as inflammatory response, cellular stress response, and cell apoptosis. | Evid Based Complement Alternat Med. 2021 Oct 1;2021:7992688. doi: 10.1155/2021/7992688. eCollection 2021. | Stress Response | Mechanism |
| 25206746 | These 21 genes encode stress-response proteins, DNA injury and repair proteins, apoptotic proteins, ion channel receptors, growth factors, and cell cycle-related proteins. | Neural Regen Res. 2014 Jan 1;9(1):76-83. doi: 10.4103/1673-5374.125333. | Stress Response | Mechanism |
| 36636219 | The HPA axis is a nerve endocrine system that regulates the stress reaction of the body. | Heliyon. 2022 Dec 22;8(12):e12574. doi: 10.1016/j.heliyon.2022.e12574. eCollection 2022 Dec. | Endocrinology Stress Response | Mechanism |
| 29853959 | Therefore, we speculate that acupuncture may reduce BP by inhibiting oxidative stress response, which is regulated by ROS formation and PPP. | Evid Based Complement Alternat Med. 2018 Apr 26;2018:5712857. doi: 10.1155/2018/5712857. eCollection 2018. | Stress Response Blood Pressure | Mechanism |
| 25206591 | In particular, it stimulates the pituitary gland and initiates the tightly regulated stress response. | Neural Regen Res. 2013 Jan 25;8(3):218-25. doi: 10.3969/j.issn.1673-5374.2013.03.003. | Stress Response | Mechanism |
| 26654890 | In the present study, it is noteworthy that the dorsal thalamus showed increased glucose metabolic activity during both the first and 20th treatments in AD+HT7 versus AD+Sham groups, which may represent an acute stress reaction. | Acupunct Med. 2016 Jun;34(3):215-22. doi: 10.1136/acupmed-2015-010865. Epub 2015 Dec 9. | Stress Response | Mechanism |
| 30431067 | The effects of the treatment on oxidative stress response and the function of the mitochondria in brain tissues were also assessed. | Int J Mol Med. 2019 Jan;43(1):221-232. doi: 10.3892/ijmm.2018.3981. Epub 2018 Nov 6. | Stress Response | Mechanism |
| 23878591 | For example, different caliber blood vessels closely related to the different types of neural endings which had different neurotransmitters and peptides regulated the flow of the peripheral blood circulation precisely then influenced the transport and distribution of body fluid and took part in the stress response and nerve-endocrine-immunity procedure. | Evid Based Complement Alternat Med. 2013;2013:160651. doi: 10.1155/2013/160651. Epub 2013 Jun 26. | Immunity Endocrinology Stress Response Circulation | Mechanism |
| 28357997 | found that there is a unique groove or trigger site, i.e., BH III death domain (α-helix structure), in the BAX protein that triggers BAX activation under certain circumstances (such as upon activation of the cellular stress response). | Med Sci Monit. 2017 Mar 30;23:1522-1532. doi: 10.12659/msm.897689. | Stress Response | Mechanism |
| 34393735 | In this study, we examined the effects of acupuncture on the suppression of depressive-like symptoms in an SDS-induced depression mouse model that is attacked by other animals to mimic the mental stress response that would occur in a more natural environment. | Front Behav Neurosci. 2021 Jul 28;15:685433. doi: 10.3389/fnbeh.2021.685433. eCollection 2021. | Stress Response Depression | Mechanism |
| 35484628 | Actually, the upregulation and production of cytokines, such as TNF-α and IL-6, represent an intrinsic or an innate stress response against myocardial injury, and they were regulated by acupuncture. | Chin Med. 2022 Apr 28;17(1):52. doi: 10.1186/s13020-022-00606-7. | Stress Response | Mechanism |
| 28761425 | Heat shock protein 70 and other endogenous injury-signaling molecules are released by damaged cells, which can lead to systemic stress reactions. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Stress Response | Mechanism |
| 28761425 | Release of adrenocorticotrophic hormone (ACTH) from the pituitary gland is a key signal that precedes the body's stress response. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Stress Response | Mechanism |
| 28761425 | A strong stress response occurs in the acute phase of cerebral ischemia. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Stress Response | Mechanism |
| 28761425 | Heat shock protein 70 (Hsp70) is a protein involved in the stress response, and is the most conservative and dominant type of HSP family. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Stress Response | Mechanism |
| 28761425 | This activates the stress response to systemic injury, and inflammatory mediators and chemokines are released to accelerate inflammation. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Stress Response | Mechanism |
| 28761425 | After the stress response was triggered, their expression levels exhibited bimodal trends. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Stress Response | Mechanism |
| 28761425 | This evidence indicates that cerebral ischemia/reperfusion injury can be relieved by EA by suppressing excessive stress responses, reducing inflammatory injury, promoting the contact between cells, and starting the repair process. | Neural Regen Res. 2017 Jun;12(6):925-930. doi: 10.4103/1673-5374.208574. | Stress Response | Mechanism |
| 25887143 | In vivo recording the activities of stress reaction neurons (SRNs, CRH-like neurons) in hypothalamic paraventricular nucleus (PVN) in response to the stimulations from different acupoints could therefore objectively reflect the acupuncture afferent effect. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 25887143 | These hormones are the principal components of stress responses through hypothalamus-hypophysis axis. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 25887143 | The exogenous glucocorticoids regulate the secretion of CRH from PVN via feedback regulation on hypothalamic-pituitary- adrenal cortex axis (HPAA), reduce stress response, influence responses in hippocampus and other limbic system, and impact the arousal, cognition and affection. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 25887143 | The neurons that involved in stress reaction were further determined and selected via their reaction to sexual hormones. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 25887143 | As a result, it was to explore whether the acupoints for the specific activation on stress reaction and hydrocortisone sensitive neurons were also the specificity acupoints for the regulation of corticosterone secretion as well as the expressions of CRH and GR protein in PVN. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 25887143 | Of those 10 neurons, the firing of 1 neuron was slightly stronger after temperature increase while the firing of the rest 9 neurons did not change, indicating that these 490 neurons belong to the non-stress reaction-related neurons in PVN. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 25887143 | In order to further determine whether or not the recorded neurons in response to noxious stimulus were related to stress reaction, we selected 47 neurons from 121 excitatory neurons and injected hydrocortisone intravenously. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 25887143 | Figure 2B illustrated the sites of stress reactive neurons recorded in the experiment. | BMC Complement Altern Med. 2015 Mar 27;15:87. doi: 10.1186/s12906-015-0625-4. | Stress Response | Mechanism |
| 29946236 | Also, animal studies demonstrate that chronic stress can lead to elevated IL-1β in several brain regions, including the hippocampus, a key area implicated in the stress response and responsible for memory and emotion (Liu et al.,; Pan et al.,). | Front Mol Neurosci. 2018 May 31;11:149. doi: 10.3389/fnmol.2018.00149. eCollection 2018. | Stress Response Mood | Mechanism |
| 25530777 | Many neuropeptide expressions are observed producing noticeable changes during the process of stress reaction, such as galanin (Gal), neuropeptide Y (NPY), vasopressin (VP), corticotrophin releasing hormone (CRH), substance p (SP), and somatostatin. | Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. | Stress Response | Mechanism |
| 25530777 | The regulatory effect of Gal on neuroendocrine stress reactions and its involvement in anxious and depressive symptomatology have been thoroughly reviewed. | Evid Based Complement Alternat Med. 2014;2014:179796. doi: 10.1155/2014/179796. Epub 2014 Oct 30. | Stress Response | Mechanism |