Detail information
ID ENOM00036
Accession GSE65490
Status Public on Jan 31, 2015
Title The effects of herb-partitioned moxibustion on miRNA expression profiling in the colons of CD rats
Organism Rattus norvegicus
Experiment type Non-coding RNA profiling by array
Summary
Using the highly sensitive miRNA microarray, we screened differentially-expressed miRNAs in colons of normal control (NC) rats, model control (MC) rats and herb-partitioned moxibustion (HPM) rats. We found 40 miRNAs differentially expressed in CD rats’ colons compared with the NC rats, and HPM significantly regulated 26 miRNAs in colon tissues compared with the MC group. Furthermore, the quantitative real-time polymerase chain reaction results showed that down-regulated miR-147 and miR-205 in CD rats’ colons were both significantly up-regulated by HPM, with 2.64- and 3.72-folds increased respectively, indicating that miR-147 and miR-205 are the target genes of HPM in treating CD rats.
Samples
GSM ID Sample info Characteristics Description
GSM1598743 colon 1-8-1 (NC) tissue: Colon age: 8 weeks old group: normal control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598744 colon 1-5-1 (NC) tissue: Colon age: 8 weeks old group: normal control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598745 colon 1-4-1 (NC) tissue: Colon age: 8 weeks old group: normal control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598746 colon 1-3-1 (NC) tissue: Colon age: 8 weeks old group: normal control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598747 colon 2-1 (MC) tissue: Colon age: 8 weeks old group: model control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598748 colon 2-3 (MC) tissue: Colon age: 8 weeks old group: model control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598749 colon 2-8 (MC) tissue: Colon age: 8 weeks old group: model control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598750 colon 2-10 (MC) tissue: Colon age: 8 weeks old group: model control Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598751 colon 4-10 (HPM) tissue: Colon age: 8 weeks old group: herb-partitioned moxibustion Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598752 colon 4-9 (HPM) tissue: Colon age: 8 weeks old group: herb-partitioned moxibustion Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598753 colon 4-11 (HPM) tissue: Colon age: 8 weeks old group: herb-partitioned moxibustion Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
GSM1598754 colon 4-13 (HPM) tissue: Colon age: 8 weeks old group: herb-partitioned moxibustion Experimental animals were male and commercially-available SD rats (SCXK, Shanghai, China).
Platform GPL18058: Exiqon miRCURY LNA microRNA array, 7th generation [miRBase v18, condensed Probe_ID version]
Indicator
BDNF, ZNF148, ZNF518B, LRP1, LRRK2, SerpinB2, SMAD4, ErbB4, MARCKS, ADAMTS9, MMD, IL-1R1, TNF-alpha, NF-kappaB, TLR4, p38, IL-1beta, Akt
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