Detail information
ID ENOM00038
Accession GSE48293
Status Public on Dec 27, 2014
Title Gene expression data from substantia nigral regions of MPTP-intoxicated mouse brain by acupuncture
Organism Mus musculus
Experiment type Expression profiling by array
Summary
Parkinson’s disease (PD) is a representative neurodegenerative disease that is characterized the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulations at GB34 and LR3 resulted in the enhanced survival of dopaminergic neurons in the SN in the parkinsonism animal models. SN is known as an important player in brain function, in particular, movement. Behavioral tests showed that acupuncture stimulations improved the motor dysfunction in a previous study by almost 87.7%. This study investigated the changes of gene expression profiles in the SN regions of the relatively chronic parkinsonism model and demonstrated the genes that may be related to the inhibitory effect of acupuncture on the change in gene expression in the SN induced by an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication using a whole transcript array. We investigated gene expression profile changes in the substantia nigral region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3
Samples
GSM ID Sample info Characteristics Description
GSM1174263 Control mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: Control Gene expression data from normal substantia nigral regions
GSM1174264 Control mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: Control Gene expression data from normal substantia nigral regions
GSM1174265 MPTP-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP-treated Gene expression data from substantia nigral regions of MPTP-intoxicated mouse
GSM1174266 MPTP-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP-treated Gene expression data from substantia nigral regions of MPTP-intoxicated mouse
GSM1174267 MPTP and acupoints acupuncture-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated Gene expression data from substantia nigral regions following acupoints-acupuncture-treatment to MPTP-intoxicated mouse
GSM1174268 MPTP and acupoints acupuncture-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and acupoints acupuncture-treated Gene expression data from substantia nigral regions following acupoints-acupuncture-treatment to MPTP-intoxicated mouse
GSM1174269 MPTP and nonacupoints acupuncture-treated mouse 1 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated Gene expression data from substantia nigral regions following nonacupoints-acupuncture-treatment to MPTP-intoxicated mouse
GSM1174270 MPTP and nonacupoints acupuncture-treated mouse 2 substantia nigral regions gender: Male strain: C57BL/6 tissue: substantia nigral tissues developmental stage: Adult treatment: MPTP and nonacupoints acupuncture-treated Gene expression data from substantia nigral regions following nonacupoints-acupuncture-treatment to MPTP-intoxicated mouse
Platform GPL6246: [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
Indicator
Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, Ucma, 4921530L21Rik, Gm13931, GAPDH
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