Acupuncture anesthesia

Detail information

ENOM00047

Accession

GSE106799

Status

Public on Nov 14, 2017

Title

Propofol alters the mRNA profile in the developing mouse hippocampus

Organism

Mus musculus

Experiment type

Expression profiling by array

Summary

Propofol has been found to be toxic to developing neurons. The goal of the current study was to nominate novel genes predicted to underly the neurotoxicity, and use these candidates for future functional pathway assessment

Samples

GSM ID	Sample info	Characteristics	Description
GSM2850452	Control 1	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.
GSM2850453	Control 2	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.
GSM2850454	Control 3	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.
GSM2850455	Control 4	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.
GSM2850456	Propofol 1	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.
GSM2850457	Propofol 2	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.
GSM2850458	Propofol 3	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.
GSM2850459	Propofol 4	tissue: hippocampus age: 7 days-old	7 day old mice received an intraperitoneal injection of 50mg/kg propofol or 50mg/kg intralipid vehicle control, with a total exposure of 3h. This was followed by a 3h washout. Mice were sacrificed, hippocampal tissues were collected, and RNA was extracted prior to profiling.