Detail information
ID ENOM00058
Accession GSE31827
Status Public on Aug 31, 2012
Title Gene expression profiling in murine mesenchymal stem cells treated with local anesthetics (ropivacaine)
Organism Mus musculus
Experiment type Expression profiling by array
Summary
Mesenchymal stem cells (MSCs) are recruited from the blood stream to tumors, healing wounds or sites of tissue injury by multiple growth factors and chemokines where they differentiate into e.g. fibroblasts or endothelial cells. Engrafted at the sites of tissue damage, they secrete growth factors and cytokines that facilitate healing. Inhibition of MSC proliferation by prolonged application of local anesthetics (commonly used after surgery) could delay wound closure and promote wound dehiscence.
Samples
GSM ID Sample info Characteristics Description
GSM789386 MSC_control1 tissue: bone marrow strain: C57B6/J agent: no treatment sample collection time: 24 hrs R0_1
GSM789387 MSC_control2 tissue: bone marrow strain: C57B6/J agent: no treatment sample collection time: 24 hrs R0_2
GSM789388 MSC_control3 tissue: bone marrow strain: C57B6/J agent: no treatment sample collection time: 24 hrs R0_3
GSM789389 MSC_control4 tissue: bone marrow strain: C57B6/J agent: no treatment sample collection time: 24 hrs R0_4
GSM789390 MSC_ROPI1 tissue: bone marrow strain: C57B6/J agent: ropivacaine 100 uM sample collection time: 24 hrs R100_1
GSM789391 MSC_ROPI2 tissue: bone marrow strain: C57B6/J agent: ropivacaine 100 uM sample collection time: 24 hrs R100_2
GSM789392 MSC_ROPI3 tissue: bone marrow strain: C57B6/J agent: ropivacaine 100 uM sample collection time: 24 hrs R100_3
GSM789393 MSC_ROPI4 tissue: bone marrow strain: C57B6/J agent: ropivacaine 100 uM sample collection time: 24 hrs R100_4
Platform GPL14363: [MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [CDF: Brainarray Version 11.0.1, MoEx10stv1_Mm_ENSG]
Indicator
CD105, CD34, CD45, c-kit (CD117), CD44
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