Detail information
ID ENOM00080
Accession GSE178505
Status Public on Dec 31, 2021
Title Differential expression of myocardial microRNAs is implicated in dexmedetomidine induced cardioprotection in rats
Organism Rattus norvegicus
Experiment type Non-coding RNA profiling by array
Summary
Using the highly sensitive miRNA array, we screened 83 microRNAs abundant in the myocardium and we explored the functions of these miRNAs by Gene Ontology and Kyoto Encyclopedia of Genes annotation. The enrichment results indicated that these miRNAs mainly participated in the phosphatidylinositol signaling system, PI3K-Akt, and MAPK. Furthermore, the TTC staining results showed that dexmedetomidine preconditioning attenuates myocardial ischemia-reperfusion injury by desregulation of several miRNAs and their potential target genes, which will give new insights into disclosing the mechanism of dexmedetomidine-induced cardioprotection.
Samples
GSM ID Sample info Characteristics Description
GSM5393006 C1_Con age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393007 C2_Con age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393008 C3_Con age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393009 DP2_DP age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393010 DP3_DP age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393011 DP4_DP age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393012 IR1_IR age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393013 IR2_IR age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China).
GSM5393014 IR4_IR age: 8 weeks old Sex: male tissue: myocardium Rats were male and commercially-available SD rats (HSLAC, Changsha, China)
Platform GPL17107: Exiqon miRCURY LNA™ microRNA Array - hsa, mmu & rno
Indicator
Download Download data in GEO database