Detail information
ID ENOM00096
Accession GSE205202
Status Public on Jun 20, 2023
Title Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary
The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.
Samples
GSM ID Sample info Characteristics Description
GSM6208507 Rat_Baseline_0h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated rats (baseline 0h controls)
GSM6208508 Rat_Baseline_0h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated rats (baseline 0h controls)
GSM6208509 Rat_Baseline_0h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated rats (baseline 0h controls)
GSM6208510 Rat_Baseline_0h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated rats (baseline 0h controls)
GSM6208511 Rat_Baseline_0h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated rats (baseline 0h controls)
GSM6208512 Rat_Vehicle_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with vehicle at 3h after administration
GSM6208513 Rat_Vehicle_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with vehicle at 3h after administration
GSM6208514 Rat_Vehicle_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with vehicle at 3h after administration
GSM6208515 Rat_Vehicle_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with vehicle at 3h after administration
GSM6208516 Rat_Vehicle_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with vehicle at 3h after administration
GSM6208517 Rat_Vehicle_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with vehicle at 6h after administration
GSM6208518 Rat_Vehicle_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with vehicle at 6h after administration
GSM6208519 Rat_Vehicle_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with vehicle at 6h after administration
GSM6208520 Rat_Vehicle_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with vehicle at 6h after administration
GSM6208521 Rat_Vehicle_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with vehicle at 6h after administration
GSM6208522 Rat_Vehicle_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with vehicle at 9h after administration
GSM6208523 Rat_Vehicle_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with vehicle at 9h after administration
GSM6208524 Rat_Vehicle_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with vehicle at 9h after administration
GSM6208525 Rat_Vehicle_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with vehicle at 9h after administration
GSM6208526 Rat_Vehicle_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with vehicle at 9h after administration
GSM6208527 Rat_Vehicle_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with vehicle at 24h after administration
GSM6208528 Rat_Vehicle_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with vehicle at 24h after administration
GSM6208529 Rat_Vehicle_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with vehicle at 24h after administration
GSM6208530 Rat_Vehicle_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with vehicle at 24h after administration
GSM6208531 Rat_Vehicle_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with vehicle at 24h after administration
GSM6208532 Rat_APAP_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 3h after administration
GSM6208533 Rat_APAP_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 3h after administration
GSM6208534 Rat_APAP_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 3h after administration
GSM6208535 Rat_APAP_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 3h after administration
GSM6208536 Rat_APAP_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 3h after administration
GSM6208537 Rat_APAP_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 6h after administration
GSM6208538 Rat_APAP_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 6h after administration
GSM6208539 Rat_APAP_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 6h after administration
GSM6208540 Rat_APAP_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 6h after administration
GSM6208541 Rat_APAP_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 6h after administration
GSM6208542 Rat_APAP_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 9h after administration
GSM6208543 Rat_APAP_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 9h after administration
GSM6208544 Rat_APAP_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 9h after administration
GSM6208545 Rat_APAP_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 9h after administration
GSM6208546 Rat_APAP_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 9h after administration
GSM6208547 Rat_APAP_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 24h after administration
GSM6208548 Rat_APAP_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 24h after administration
GSM6208549 Rat_APAP_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 24h after administration
GSM6208550 Rat_APAP_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 24h after administration
GSM6208551 Rat_APAP_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of rats treated with 1000 mg/kg APAP at 24h after administration
Platform GPL22499: [Rat230_2] Affymetrix Rat Genome 230 2.0 Array [CDF: Rat2302_Rn_ENTREZG_19.0.0]
Indicator
Nrf2
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