Detail information
ID ENOM00097
Accession GSE205201
Status Public on Jun 20, 2023
Title Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]
Organism Mus musculus
Experiment type Expression profiling by array
Summary
The well-known difference in sensitivity of mice and rats to acetaminophen (APAP) liver injury has been related to differences in the fraction that is bioactivated to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI). Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.
Samples
GSM ID Sample info Characteristics Description
GSM6208462 Mouse_Baseline_0h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated mice (baseline 0h controls)
GSM6208463 Mouse_Baseline_0h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated mice (baseline 0h controls)
GSM6208464 Mouse_Baseline_0h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated mice (baseline 0h controls)
GSM6208465 Mouse_Baseline_0h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated mice (baseline 0h controls)
GSM6208466 Mouse_Baseline_0h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 Gene expression data from liver of untreated mice (baseline 0h controls)
GSM6208467 Mouse_Vehicle_03h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with vehicle at 3h after administration
GSM6208468 Mouse_Vehicle_03h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with vehicle at 3h after administration
GSM6208469 Mouse_Vehicle_03h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with vehicle at 3h after administration
GSM6208470 Mouse_Vehicle_03h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with vehicle at 3h after administration
GSM6208471 Mouse_Vehicle_03h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with vehicle at 3h after administration
GSM6208472 Mouse_Vehicle_06h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with vehicle at 6h after administration
GSM6208473 Mouse_Vehicle_06h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with vehicle at 6h after administration
GSM6208474 Mouse_Vehicle_06h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with vehicle at 6h after administration
GSM6208475 Mouse_Vehicle_06h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with vehicle at 6h after administration
GSM6208476 Mouse_Vehicle_06h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with vehicle at 6h after administration
GSM6208477 Mouse_Vehicle_09h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with vehicle at 9h after administration
GSM6208478 Mouse_Vehicle_09h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with vehicle at 9h after administration
GSM6208479 Mouse_Vehicle_09h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with vehicle at 9h after administration
GSM6208480 Mouse_Vehicle_09h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with vehicle at 9h after administration
GSM6208481 Mouse_Vehicle_09h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with vehicle at 9h after administration
GSM6208482 Mouse_Vehicle_24h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with vehicle at 24h after administration
GSM6208483 Mouse_Vehicle_24h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with vehicle at 24h after administration
GSM6208484 Mouse_Vehicle_24h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with vehicle at 24h after administration
GSM6208485 Mouse_Vehicle_24h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with vehicle at 24h after administration
GSM6208486 Mouse_Vehicle_24h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with vehicle at 24h after administration
GSM6208487 Mouse_APAP_03h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with 300 mg/kg APAP at 3h after administration
GSM6208488 Mouse_APAP_03h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with 300 mg/kg APAP at 3h after administration
GSM6208489 Mouse_APAP_03h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with 300 mg/kg APAP at 3h after administration
GSM6208490 Mouse_APAP_03h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with 300 mg/kg APAP at 3h after administration
GSM6208491 Mouse_APAP_03h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 Gene expression data from liver of mice treated with 300 mg/kg APAP at 3h after administration
GSM6208492 Mouse_APAP_06h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with 300 mg/kg APAP at 6h after administration
GSM6208493 Mouse_APAP_06h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with 300 mg/kg APAP at 6h after administration
GSM6208494 Mouse_APAP_06h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with 300 mg/kg APAP at 6h after administration
GSM6208495 Mouse_APAP_06h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with 300 mg/kg APAP at 6h after administration
GSM6208496 Mouse_APAP_06h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 Gene expression data from liver of mice treated with 300 mg/kg APAP at 6h after administration
GSM6208497 Mouse_APAP_09h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with 300 mg/kg APAP at 9h after administration
GSM6208498 Mouse_APAP_09h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with 300 mg/kg APAP at 9h after administration
GSM6208499 Mouse_APAP_09h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with 300 mg/kg APAP at 9h after administration
GSM6208500 Mouse_APAP_09h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with 300 mg/kg APAP at 9h after administration
GSM6208501 Mouse_APAP_09h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 Gene expression data from liver of mice treated with 300 mg/kg APAP at 9h after administration
GSM6208502 Mouse_APAP_24h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with 300 mg/kg APAP at 24h after administration
GSM6208503 Mouse_APAP_24h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with 300 mg/kg APAP at 24h after administration
GSM6208504 Mouse_APAP_24h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with 300 mg/kg APAP at 24h after administration
GSM6208505 Mouse_APAP_24h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with 300 mg/kg APAP at 24h after administration
GSM6208506 Mouse_APAP_24h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 Gene expression data from liver of mice treated with 300 mg/kg APAP at 24h after administration
Platform GPL29970: [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array [CDF: Mouse4302_Mm_ENTREZG Brainarray version 24.0.0]
Indicator
Nrf2
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