Detail information
ID ENOM00100
Accession GSE214563
Status Public on Aug 30, 2023
Title Transcriptional effects of extended opioid exposure in clear cell renal cell carcinomas.
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary
Opioids are commonly prescribed to patients with advanced clear cell renal cell carcinoma for extended periods of time in assistance for pain management. Because extended opioid exposure has been shown to affect the vasculature and to be immunosuppressive, we investigated how it may affect the metabolism and physiology of advanced clear cell renal cell carcinoma. RNA sequencing of archived patient’s specimens with extended opioid exposure or non-opioid exposure were peformed.
Samples
GSM ID Sample info Characteristics Description
GSM6611803 ccRCC_OpioidNaive_1 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Opioid naive
GSM6611804 ccRCC_OpioidNaive_2 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Opioid naive
GSM6611805 ccRCC_ExtendedOpioid_1 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Extended opioid exposure
GSM6611806 ccRCC_ExtendedOpioid_2 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Extended opioid exposure
GSM6611807 ccRCC_OpioidNaive_3 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Opioid naive
GSM6611808 ccRCC_ExtendedOpioid_3 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Extended opioid exposure
GSM6611809 ccRCC_OpioidNaive_4 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Opioid naive
GSM6611810 ccRCC_ExtendedOpioid_4 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Extended opioid exposure
GSM6611811 ccRCC_ExtendedOpioid_5 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Extended opioid exposure
GSM6611812 ccRCC_OpioidNaive_5 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Opioid naive
GSM6611813 ccRCC_OpioidNaive_6 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Opioid naive
GSM6611814 ccRCC_OpioidNaive_7 tissue: Advanced clear cell renal cell carcinoma - tumor FFPE treatment: Opioid naive
Platform GPL24676: Illumina NovaSeq 6000 (Homo sapiens)
Indicator
CREB, AKT1, AKT2, FOS, PDE10A, RAC1, PAK1, PLD2
Download Download data in GEO database