Detail information
ID ENOM00117
Accession GSE225158
Status Public on Nov 28, 2023
Title Transcriptional responses of the human dorsal striatum in opioid use disorder implicates cell type-specifc programs
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary
Gene expression profile at single cell level of striatal cells from the caudate nucleus and putamen in postmortem human brains of unaffected individuals or those with opioid use disorder.
Samples
GSM ID Sample info Characteristics Description
GSM7040221 C-1366 tissue: Caudate cell type: striatal cells pair: 1 subject: 1366 Sex: F race: W age: 35 bmi: 35.2 pmi: 11 ph: 6.1 rin: 7.1 tissue.storage.time.mo: 149 dx oud: OUD dx substances: Poly-SUD dx comorbid: Pain Disorder dur.oud: 8 dsm.iv.sud: Opioid Dependence; Sedative or Hypnotic or Anxiolytic Dependence dsm.iv.psych: Pain Disorder Associated with Both Psychological Factors and a General Medical Condition blood.toxicology: Methadone, Tramadol, Alprazolam, Diphenhydramine infxn.dx: Asthma; Recurrent Bronchitis medications.atodc: B, O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040222 C-13281 tissue: Caudate cell type: striatal cells pair: 1 subject: 1366 Sex: F race: W age: 35 bmi: 35.2 pmi: 11 ph: 6.1 rin: 7.1 tissue.storage.time.mo: 149 dx oud: OUD dx substances: Poly-SUD dx comorbid: Pain Disorder dur.oud: 8 dsm.iv.sud: Opioid Dependence; Sedative or Hypnotic or Anxiolytic Dependence dsm.iv.psych: Pain Disorder Associated with Both Psychological Factors and a General Medical Condition blood.toxicology: Methadone, Tramadol, Alprazolam, Diphenhydramine infxn.dx: Asthma; Recurrent Bronchitis medications.atodc: B, O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040223 C-1252 tissue: Caudate cell type: striatal cells pair: 1 subject: 1366 Sex: F race: W age: 35 bmi: 35.2 pmi: 11 ph: 6.1 rin: 7.1 tissue.storage.time.mo: 149 dx oud: OUD dx substances: Poly-SUD dx comorbid: Pain Disorder dur.oud: 8 dsm.iv.sud: Opioid Dependence; Sedative or Hypnotic or Anxiolytic Dependence dsm.iv.psych: Pain Disorder Associated with Both Psychological Factors and a General Medical Condition blood.toxicology: Methadone, Tramadol, Alprazolam, Diphenhydramine infxn.dx: Asthma; Recurrent Bronchitis medications.atodc: B, O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040224 C-1670 tissue: Caudate cell type: striatal cells pair: 12 subject: 1670 Sex: M race: W age: 42 bmi: 36.2 pmi: 18.5 ph: 6.5 rin: 8.1 tissue.storage.time.mo: 95.2 dx oud: OUD dx substances: OUD-only dx comorbid: None dur.oud: 17 dsm.iv.sud: Opioid Dependence dsm.iv.psych: None blood.toxicology: Morphine, Oxycodone infxn.dx: Osteomyelitis with Non-healing Ulcer; Recurring Foot Infections medications.atodc: O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040225 C-1262 tissue: Caudate cell type: striatal cells pair: 14 subject: 1262 Sex: M race: W age: 41 bmi: 29.9 pmi: 16.3 ph: 6.7 rin: 7.2 tissue.storage.time.mo: 168 dx oud: OUD dx substances: Poly-SUD dx comorbid: None dur.oud: 4 dsm.iv.sud: Opioid Dependence; Cocaine Dependence; Sedative or Hypnotic or Anxiolytic Dependence dsm.iv.psych: None blood.toxicology: Fentanyl, Norfentanyl, Lidocaine, Butalbital, Cocaine Metabolites, Trazodone, Alprazolam, Citalopram, Acetaminophen medications.atodc: B, D tobacco.atod: N manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040226 C-13114 tissue: Caudate cell type: striatal cells pair: 3 subject: 13114 Sex: F race: B age: 54 bmi: 27.6 pmi: 13.7 ph: 6.3 rin: 8.7 tissue.storage.time.mo: 46.8 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected infxn.dx: Arthritis medications.atodc: O tobacco.atod: Y manner.of.death: Natural cause.of.death: Cardiovascular Disease
GSM7040227 C-13151 tissue: Caudate cell type: striatal cells pair: 6 subject: 13151 Sex: F race: W age: 55 bmi: 44.9 pmi: 13.4 ph: 6.2 rin: 7 tissue.storage.time.mo: 41.7 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected infxn.dx: Degenerative Joint Disease medications.atodc: O tobacco.atod: N manner.of.death: Natural cause.of.death: Cardiovascular Disease
GSM7040228 C-612 tissue: Caudate cell type: striatal cells pair: 20 subject: 612 Sex: M race: W age: 60 bmi: 37.5 pmi: 9.6 ph: 6.8 rin: 9 tissue.storage.time.mo: 270.2 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected medications.atodc: N tobacco.atod: U manner.of.death: Accidental cause.of.death: Aspiration
GSM7040229 C-13291 tissue: Caudate cell type: striatal cells pair: 2 subject: 13291 Sex: M race: B age: 37 bmi: 36.3 pmi: 18 ph: 6.9 rin: 7.5 tissue.storage.time.mo: 23.1 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected medications.atodc: U tobacco.atod: U manner.of.death: Natural cause.of.death: Cardiac Tamponade
GSM7040230 C-1488 tissue: Caudate cell type: striatal cells pair: 4 subject: 1488 Sex: M race: B age: 39 bmi: 33.1 pmi: 21.5 ph: 6.6 rin: 8.7 tissue.storage.time.mo: 127.2 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected infxn.dx: Asthma medications.atodc: N tobacco.atod: Y manner.of.death: Natural cause.of.death: Pulmonary Embolism
GSM7040231 P-1366 tissue: Putamen cell type: striatal cells pair: 1 subject: 1366 Sex: F race: W age: 35 bmi: 35.2 pmi: 11 ph: 6.1 rin: 7.1 tissue.storage.time.mo: 149 dx oud: OUD dx substances: Poly-SUD dx comorbid: Pain Disorder dur.oud: 8 dsm.iv.sud: Opioid Dependence; Sedative or Hypnotic or Anxiolytic Dependence dsm.iv.psych: Pain Disorder Associated with Both Psychological Factors and a General Medical Condition blood.toxicology: Methadone, Tramadol, Alprazolam, Diphenhydramine infxn.dx: Asthma; Recurrent Bronchitis medications.atodc: B, O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040232 P-13281 tissue: Putamen cell type: striatal cells pair: 6 subject: 13281 Sex: F race: W age: 54 bmi: 17.8 pmi: 12.5 ph: 6.9 rin: 8.8 tissue.storage.time.mo: 24.1 dx oud: OUD dx substances: Poly-SUD dx comorbid: None dur.oud: 5 dsm.iv.sud: Opioid Dependence; Sedative or Hypnotic or Anxiolytic Dependence dsm.iv.psych: None blood.toxicology: Fentanyl, Meprobamate medications.atodc: B, C, D, L, O, P tobacco.atod: Y manner.of.death: Accidental cause.of.death: Fentanyl Overdose
GSM7040233 P-1252 tissue: Putamen cell type: striatal cells pair: 4 subject: 1252 Sex: M race: W age: 40 bmi: 25.9 pmi: 21.1 ph: 6.5 rin: 7.6 tissue.storage.time.mo: 167.5 dx oud: OUD dx substances: Poly-SUD dx comorbid: MDD dur.oud: 13 dsm.iv.sud: Opioid Dependence; Alcohol Dependence; Cocaine Dependence; Polysubstance Dependence dsm.iv.psych: Major Depressive Disorder, Single Episode, Severe without Psychotic Features blood.toxicology: Morphine, Phenobarbital, Cocaine Metabolites infxn.dx: Arthritis medications.atodc: O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040234 P-1670 tissue: Putamen cell type: striatal cells pair: 12 subject: 1670 Sex: M race: W age: 42 bmi: 36.2 pmi: 18.5 ph: 6.5 rin: 8.1 tissue.storage.time.mo: 95.2 dx oud: OUD dx substances: OUD-only dx comorbid: None dur.oud: 17 dsm.iv.sud: Opioid Dependence dsm.iv.psych: None blood.toxicology: Morphine, Oxycodone infxn.dx: Osteomyelitis with Non-healing Ulcer; Recurring Foot Infections medications.atodc: O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040235 P-1262 tissue: Putamen cell type: striatal cells pair: 14 subject: 1262 Sex: M race: W age: 41 bmi: 29.9 pmi: 16.3 ph: 6.7 rin: 7.2 tissue.storage.time.mo: 168 dx oud: OUD dx substances: Poly-SUD dx comorbid: None dur.oud: 4 dsm.iv.sud: Opioid Dependence; Cocaine Dependence; Sedative or Hypnotic or Anxiolytic Dependence dsm.iv.psych: None blood.toxicology: Fentanyl, Norfentanyl, Lidocaine, Butalbital, Cocaine Metabolites, Trazodone, Alprazolam, Citalopram, Acetaminophen medications.atodc: B, D tobacco.atod: N manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040236 P-13114 tissue: Putamen cell type: striatal cells pair: 3 subject: 13114 Sex: F race: B age: 54 bmi: 27.6 pmi: 13.7 ph: 6.3 rin: 8.7 tissue.storage.time.mo: 46.8 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected infxn.dx: Arthritis medications.atodc: O tobacco.atod: Y manner.of.death: Natural cause.of.death: Cardiovascular Disease
GSM7040237 P-13151 tissue: Putamen cell type: striatal cells pair: 6 subject: 13151 Sex: F race: W age: 55 bmi: 44.9 pmi: 13.4 ph: 6.2 rin: 7 tissue.storage.time.mo: 41.7 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected infxn.dx: Degenerative Joint Disease medications.atodc: O tobacco.atod: N manner.of.death: Natural cause.of.death: Cardiovascular Disease
GSM7040238 P-612 tissue: Putamen cell type: striatal cells pair: 20 subject: 612 Sex: M race: W age: 60 bmi: 37.5 pmi: 9.6 ph: 6.8 rin: 9 tissue.storage.time.mo: 270.2 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected medications.atodc: N tobacco.atod: U manner.of.death: Accidental cause.of.death: Aspiration
GSM7040239 P-13291 tissue: Putamen cell type: striatal cells pair: 2 subject: 13291 Sex: M race: B age: 37 bmi: 36.3 pmi: 18 ph: 6.9 rin: 7.5 tissue.storage.time.mo: 23.1 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected medications.atodc: U tobacco.atod: U manner.of.death: Natural cause.of.death: Cardiac Tamponade
GSM7040240 P-1488 tissue: Putamen cell type: striatal cells pair: 4 subject: 1488 Sex: M race: B age: 39 bmi: 33.1 pmi: 21.5 ph: 6.6 rin: 8.7 tissue.storage.time.mo: 127.2 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected infxn.dx: Asthma medications.atodc: N tobacco.atod: Y manner.of.death: Natural cause.of.death: Pulmonary Embolism
GSM7040241 C-1034 tissue: Caudate cell type: striatal cells pair: 11 subject: 1034 Sex: F race: W age: 23 bmi: 20 pmi: 8.5 ph: 7 rin: 7.8 tissue.storage.time.mo: 197.2 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected medications.atodc: N tobacco.atod: N manner.of.death: Natural cause.of.death: Endocardial Fibroelastosis
GSM7040242 P-1034 tissue: Putamen cell type: striatal cells pair: 11 subject: 1034 Sex: F race: W age: 23 bmi: 20 pmi: 8.5 ph: 7 rin: 7.8 tissue.storage.time.mo: 197.2 dx oud: None dx substances: None dx comorbid: None dur.oud: 0 blood.toxicology: No substances detected medications.atodc: N tobacco.atod: N manner.of.death: Natural cause.of.death: Endocardial Fibroelastosis
GSM7040243 C-1572 tissue: Caudate cell type: striatal cells pair: 11 subject: 1572 Sex: F race: W age: 35 bmi: 40.9 pmi: 11.8 ph: 6.5 rin: 9.1 tissue.storage.time.mo: 111.4 dx oud: OUD dx substances: OUD-only dx comorbid: None dur.oud: 5 dsm.iv.sud: Opioid Dependence dsm.iv.psych: None blood.toxicology: Methadone, Methadone Metabolite, Trazodone infxn.dx: Osteoarthritis; Degenerative Changes of Cervical Spine medications.atodc: B, O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
GSM7040244 P-1572 tissue: Putamen cell type: striatal cells pair: 11 subject: 1572 Sex: F race: W age: 35 bmi: 40.9 pmi: 11.8 ph: 6.5 rin: 9.1 tissue.storage.time.mo: 111.4 dx oud: OUD dx substances: OUD-only dx comorbid: None dur.oud: 5 dsm.iv.sud: Opioid Dependence dsm.iv.psych: None blood.toxicology: Methadone, Methadone Metabolite, Trazodone infxn.dx: Osteoarthritis; Degenerative Changes of Cervical Spine medications.atodc: B, O, Z tobacco.atod: Y manner.of.death: Accidental cause.of.death: Combined Drug Overdose
Platform GPL18573: Illumina NextSeq 500 (Homo sapiens)
Indicator
CEBPB, FOXP2, STAT3, CMP2, HLA-F, IFI44, PPM1B, RSAD2, NFKB1, HPF1, TCF7L2, RXRG
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