Acupuncture anesthesia

Detail information

ENOM00122

Accession

GSE192399

Status

Public on Dec 22, 2021

Title

Gene expression of brain regions activated by sevoflurane and propofol

Organism

Rattus norvegicus

Experiment type

Expression profiling by array

Summary

The basic mechanisms of action for general anesthesia are not fully understood. We thought differences in the neural activation sites of different types of anesthetics and differences in gene expression changes in those brain regions may lead to differences in the incidence of side effects. We performed gene expression analysis using microarrays in the identified regions that have been related to the mechanisms of anesthetic action and side effects. Gene expression changes in these brain regions were determined for sevoflurane and propofol to understand the mechanisms that cause differences among anesthetics.

Samples

GSM ID	Sample info	Characteristics	Description
GSM5746332	LHb, Sevoflurane, 60mins	brain region: the lateral habenula (LHb) treatment: Sevoflurane	Gene expression data from LHb treated by sevoflurane brains of Male Wistar rats (8–10 weeks old)
GSM5746333	LHb, O2, 60mins	brain region: the lateral habenula (LHb) treatment: O2	Gene expression data from LHb treated by O2 brains of Male Wistar rats (8–10 weeks old)
GSM5746334	MHb, Sevoflurane, 60mins	brain region: the medial habenula (MHb) treatment: Sevoflurane	Gene expression data from MHb treated by sevoflurane brains of Male Wistar rats (8–10 weeks old)
GSM5746335	MHb, O2, 60mins	brain region: the medial habenula (MHb) treatment: O2	Gene expression data from MHb treated by O2 brains of Male Wistar rats (8–10 weeks old)
GSM5746336	Sol, Sevoflurane, 60mins	brain region: the solitary nucleus (Sol) treatment: Sevoflurane	Gene expression data from Sol treated by sevoflurane brains of Male Wistar rats (8–10 weeks old)
GSM5746337	Sol, O2, 60mins	brain region: the solitary nucleus (Sol) treatment: O2	Gene expression data from Sol treated by O2 brains of Male Wistar rats (8–10 weeks old)
GSM5746338	Mve, Sevoflurane, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane	Gene expression data from MVe treated by sevoflurane brains of Male Wistar rats (8–10 weeks old)
GSM5746339	Mve, O2, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: O2	Gene expression data from MVe treated by O2 brains of Male Wistar rats (8–10 weeks old)
GSM5746340	LHb, Propofol, 60mins	brain region: the lateral habenula (LHb) treatment: Propofol	Gene expression data from LHb treated by propofol brains of Male Wistar rats (8–10 weeks old)
GSM5746341	LHb, Intralipos, 60mins	brain region: the lateral habenula (LHb) treatment: Intralipos	Gene expression data from LHb treated by intralipos brains of Male Wistar rats (8–10 weeks old)
GSM5746342	MHb, Propofol, 60mins	brain region: the medial habenula (MHb) treatment: Propofol	Gene expression data from MHb treated by propofol brains of Male Wistar rats (8–10 weeks old)
GSM5746343	MHb, Intralipos, 60mins	brain region: the medial habenula (MHb) treatment: Intralipos	Gene expression data from MHb treated by intralipos brains of Male Wistar rats (8–10 weeks old)
GSM5746344	Sol, Propofol, 60mins	brain region: the solitary nucleus (Sol) treatment: Propofol	Gene expression data from Sol treated by propofol brains of Male Wistar rats (8–10 weeks old)
GSM5746345	Sol, Intralipos, 60mins	brain region: the solitary nucleus (Sol) treatment: Intralipos	Gene expression data from Sol treated by intralipos brains of Male Wistar rats (8–10 weeks old)
GSM5746346	MVe, Propofol, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: Propofol	Gene expression data from MVe treated by propofol brains of Male Wistar rats (8–10 weeks old)
GSM5746347	MVe, Intralipos, 60mins	brain region: the medial vestibular nucleus (MVe) treatment: Intralipos	Gene expression data from MVe treated by intralipos brains of Male Wistar rats (8–10 weeks old)