Detail information
ID ENOM00134
Accession GSE126662
Status Public on Apr 14, 2020
Title Comparison between opioid (morphine) and vehicle treatments in mouse trigeminal ganglia and nucleus accumbens
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary
Chronic opioid treatment elicits hyperalgesia in mice that is significantly augmented by a human migraine trigger and reduced with migraine therapy. The purpose of this study was to profile mRNA levels (transcriptome) to understand the differences between opioid (morphine) and vehicle treatments in two nervous system regions, the trigeminal ganglia and the nucleus accumbens. Mice received 10 mL/kg intraperitoneal injections of either morphine or vehicle volume twice daily (s.c.) for 4 days where on days 1-3 the dose of morphine was 20 mg/kg, and on day 4 it was 40 mg/kg.
Samples
GSM ID Sample info Characteristics Description
GSM3610703 TG_M1: OIH_M1_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610704 TG_M2: OIH_M2_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610705 TG_M3: OIH_M3_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610706 TG_M4: OIH_M4_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610707 TG_M5: OIH_M5_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610708 TG_V1: VehicleOIH_V1_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610709 TG_V2: VehicleOIH_V2_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610710 TG_V3: VehicleOIH_V3_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610711 TG_V4: VehicleOIH_V4_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610712 TG_V5: VehicleOIH_V5_Trigeminal_Ganglia tissue: Trigeminal ganglia strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610713 NAc_M1: OIH_M1_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610714 NAc_M2: OIH_M2_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610715 NAc_M3: OIH_M3_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610716 NAc_M4: OIH_M4_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610717 NAc_M5: OIH_M5_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: OIH age: 9-12 weeks old Sex: male
GSM3610718 NAc_V1: VehicleOIH_V1_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610719 NAc_V2: VehicleOIH_V2_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610720 NAc_V3: VehicleOIH_V3_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610721 NAc_V4: VehicleOIH_V4_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
GSM3610722 NAc_V5: VehicleOIH_V5_Nucleus_Accumbens tissue: Nucleus accumbens strain: C57BL/6J treatment: Vehicle age: 9-12 weeks old Sex: male
Platform GPL21103: Illumina HiSeq 4000 (Mus musculus)
Indicator
Per2, Per3, E2f6, Bcl3, Hsf1, Dbp, Mlxipl, Bhlhe41, HIf, Lnpep, Ciart, Zfp369, Dbp, Arntl, Ciita, Mpz, Gnb3, Prph
Download Download data in GEO database