Acupuncture anesthesia

Detail information

ENOM00137

Accession

GSE48954

Status

Public on Jul 18, 2013

Title

Psychotropic drug-induced gene expression alterations in mouse striatum II

Organism

Mus musculus

Experiment type

Expression profiling by array

Summary

To identify the molecular mechanisms that may initiate therapeutic effects, whole-genome expression profiling (Illumina Mouse WG-6 microarrays) of drug-induced alterations in the mouse brain was undertaken, with a focus on the time-course (1, 2, 4 and 8h) of gene expression changes produced by eighteen major psychotropic drugs: antidepressants, antipsychotics, anxiolytics, psychostimulants and opioids. The resulting database is freely accessible at www.genes2mind.org. Bioinformatics approaches led to the identification of three main drug-responsive genomic networks and indicated neurobiological pathways that mediate the alterations in transcription. Each tested psychotropic drug was characterized by a unique gene network expression profile related to its neuropharmacological properties. Functional links that connect expression of the networks to the development of neuronal adaptations (MAPK signaling pathway), control of brain metabolism (adipocytokine pathway), and organization of cell projections (mTOR pathway) were found. The additional data-sets are available at GEOX1 and GEOX2.

Samples

GSM ID	Sample info	Characteristics	Description
GSM1187415	BUP_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Bupropion	5316830053_A
GSM1187416	HAL_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Haloperidol	5316830053_B
GSM1187417	MIA_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Mianserin	5316830053_C
GSM1187418	NAI_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Naive	5316830053_D
GSM1187419	SAL_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Saline	5316830053_E
GSM1187420	TRA_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Tranylcypromine	5316830053_F
GSM1187421	BUP_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Bupropion	5426836040_A
GSM1187422	HAL_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Haloperidol	5426836040_B
GSM1187423	MIA_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Mianserin	5426836040_C
GSM1187424	NAI_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Naive	5426836040_D
GSM1187425	SAL_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Saline	5426836040_E
GSM1187426	TRA_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Tranylcypromine	5426836040_F
GSM1187427	BUP_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Bupropion	5426836047_A
GSM1187428	HAL_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Haloperidol	5426836047_B
GSM1187429	MIA_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Mianserin	5426836047_C
GSM1187430	NAI_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Naive	5426836047_D
GSM1187431	SAL_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Saline	5426836047_E
GSM1187432	TWE_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Tween 80	5426836047_F
GSM1187433	BUP_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Bupropion	5426836048_A
GSM1187434	HAL_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Haloperidol	5426836048_B
GSM1187435	MIA_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Mianserin	5426836048_C
GSM1187436	RIS_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Risperidone	5426836048_D
GSM1187437	SAL_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Saline	5426836048_E
GSM1187438	NAI_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Naive	5426836048_F
GSM1187439	BUP_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Bupropion	5426836055_A
GSM1187440	HAL_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Haloperidol	5426836055_B
GSM1187441	MIA_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Mianserin	5426836055_C
GSM1187442	RIS_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Risperidone	5426836055_D
GSM1187443	SAL_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Saline	5426836055_E
GSM1187444	TWE_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Tween 80	5426836055_F
GSM1187445	BUP_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Bupropion	5426836062_A
GSM1187446	KLO_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Clozapine	5426836062_B
GSM1187447	MIA_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Mianserin	5426836062_C
GSM1187448	RIS_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Risperidone	5426836062_D
GSM1187449	SAL_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Saline	5426836062_E
GSM1187450	HAL_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Haloperidol	5426836062_F
GSM1187451	BUP_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Bupropion	5426836067_A
GSM1187452	KLO_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Clozapine	5426836067_B
GSM1187453	MIA_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Mianserin	5426836067_C
GSM1187454	RIS_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Risperidone	5426836067_D
GSM1187455	SAL_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Saline	5426836067_E
GSM1187456	TWE_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Tween 80	5426836067_F
GSM1187457	DIA_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Diazepam	5513075002_A
GSM1187458	SAL_VIII_6 [II]	strain: C57Bl/6J timepoint: 8h drug: Saline	5513075002_B
GSM1187459	BUS_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Buspirone	5513075002_C
GSM1187460	HYD_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Hydroxizine	5513075002_D
GSM1187461	BUS_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Buspirone	5513075002_E
GSM1187462	SAL_II_4 [II]	strain: C57Bl/6J timepoint: 2h drug: Saline	5513075002_F
GSM1187463	DIA_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Diazepam	5513075007_A
GSM1187464	SAL_II_6 [II]	strain: C57Bl/6J timepoint: 2h drug: Saline	5513075007_B
GSM1187465	DIA_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Diazepam	5513075007_C
GSM1187466	HYD_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Hydroxizine	5513075007_D
GSM1187467	BUS_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Buspirone	5513075007_E
GSM1187468	HYD_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Hydroxizine	5513075007_F
GSM1187469	HYD_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Hydroxizine	5513075008_A
GSM1187470	BUS_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Buspirone	5513075008_B
GSM1187471	SAL_I_4 [II]	strain: C57Bl/6J timepoint: 1h drug: Saline	5513075008_C
GSM1187472	DIA_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Diazepam	5513075008_D
GSM1187473	SAL_IV_6 [II]	strain: C57Bl/6J timepoint: 4h drug: Saline	5513075008_E
GSM1187474	DIA_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Diazepam	5513075008_F
GSM1187475	SAL_VIII_5 [II]	strain: C57Bl/6J timepoint: 8h drug: Saline	5513075009_A
GSM1187476	BUS_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Buspirone	5513075009_B
GSM1187477	HYD_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Hydroxizine	5513075009_C
GSM1187478	BUS_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Buspirone	5513075009_D
GSM1187479	SAL_I_6 [II]	strain: C57Bl/6J timepoint: 1h drug: Saline	5513075009_E
GSM1187480	DIA_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Diazepam	5513075009_F
GSM1187481	BUP_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Bupropion	5513075013_A
GSM1187482	KLO_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Clozapine	5513075013_B
GSM1187483	NAI_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Naive	5513075013_C
GSM1187484	RIS_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Risperidone	5513075013_D
GSM1187485	TRA_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Tranylcypromine	5513075013_E
GSM1187486	TWE_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Tween 80	5513075013_F
GSM1187487	BUP_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Bupropion	5513075014_A
GSM1187488	KLO_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Clozapine	5513075014_B
GSM1187489	MIA_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Mianserin	5513075014_C
GSM1187490	RIS_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Risperidone	5513075014_D
GSM1187491	SAL_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Saline	5513075014_E
GSM1187492	TWE_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Tween 80	5513075014_F
GSM1187493	BUP_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Bupropion	5513075015_A
GSM1187494	KLO_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Clozapine	5513075015_B
GSM1187495	MIA_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Mianserin	5513075015_C
GSM1187496	RIS_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Risperidone	5513075015_D
GSM1187497	TRA_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Tranylcypromine	5513075015_E
GSM1187498	SAL_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Saline	5513075015_F
GSM1187499	HAL_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Haloperidol	5513075019_A
GSM1187500	KLO_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Clozapine	5513075019_B
GSM1187501	NAI_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Naive	5513075019_C
GSM1187502	RIS_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Risperidone	5513075019_D
GSM1187503	TRA_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Tranylcypromine	5513075019_E
GSM1187504	TWE_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Tween 80	5513075019_F
GSM1187505	BUP_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Bupropion	5513075020_A
GSM1187506	KLO_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Clozapine	5513075020_B
GSM1187507	MIA_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Mianserin	5513075020_C
GSM1187508	RIS_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Risperidone	5513075020_D
GSM1187509	TRA_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Tranylcypromine	5513075020_E
GSM1187510	TWE_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Tween 80	5513075020_F
GSM1187511	BUP_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Bupropion	5513075021_A
GSM1187512	KLO_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Clozapine	5513075021_B
GSM1187513	NAI_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Naive	5513075021_C
GSM1187514	RIS_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Risperidone	5513075021_D
GSM1187515	TRA_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Tranylcypromine	5513075021_E
GSM1187516	MIA_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Mianserin	5513075021_F
GSM1187517	HAL_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Haloperidol	5513075023_A
GSM1187518	KLO_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Clozapine	5513075023_B
GSM1187519	NAI_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Naive	5513075023_C
GSM1187520	SAL_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Saline	5513075023_D
GSM1187521	TRA_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Tranylcypromine	5513075023_E
GSM1187522	TWE_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Tween 80	5513075023_F
GSM1187523	HYD_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Hydroxizine	5513075029_A
GSM1187524	DIA_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Diazepam	5513075029_B
GSM1187525	SAL_IV_4 [II]	strain: C57Bl/6J timepoint: 4h drug: Saline	5513075029_C
GSM1187526	DIA_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Diazepam	5513075029_D
GSM1187527	HYD_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Hydroxizine	5513075029_E
GSM1187528	BUS_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Buspirone	5513075029_F
GSM1187529	BUS_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Buspirone	5513075032_A
GSM1187530	HYD_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Hydroxizine	5513075032_B
GSM1187531	BUS_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Buspirone	5513075032_C
GSM1187532	SAL_I_5 [II]	strain: C57Bl/6J timepoint: 1h drug: Saline	5513075032_D
GSM1187533	DIA_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Diazepam	5513075032_E
GSM1187534	SAL_VIII_4 [II]	strain: C57Bl/6J timepoint: 8h drug: Saline	5513075032_F
GSM1187535	SAL_II_5 [II]	strain: C57Bl/6J timepoint: 2h drug: Saline	5513075033_A
GSM1187536	DIA_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Diazepam	5513075033_B
GSM1187537	HYD_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Hydroxizine	5513075033_C
GSM1187538	BUS_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Buspirone	5513075033_D
GSM1187539	HYD_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Hydroxizine	5513075033_E
GSM1187540	BUS_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Buspirone	5513075033_F
GSM1187541	HAL_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Haloperidol	5513075044_A
GSM1187542	KLO_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Clozapine	5513075044_B
GSM1187543	NAI_VIII_1 [II]	strain: C57Bl/6J timepoint: 8h drug: Naive	5513075044_C
GSM1187544	RIS_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Risperidone	5513075044_D
GSM1187545	TRA_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Tranylcypromine	5513075044_E
GSM1187546	TWE_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Tween 80	5513075044_F
GSM1187547	HAL_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Haloperidol	5513075046_A
GSM1187548	KLO_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Clozapine	5513075046_B
GSM1187549	NAI_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Naive	5513075046_C
GSM1187550	SAL_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Saline	5513075046_D
GSM1187551	TRA_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Tranylcypromine	5513075046_E
GSM1187552	TWE_IV_3 [II]	strain: C57Bl/6J timepoint: 4h drug: Tween 80	5513075046_F
GSM1187553	HAL_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Haloperidol	5513075047_A
GSM1187554	KLO_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Clozapine	5513075047_B
GSM1187555	NAI_I_2 [II]	strain: C57Bl/6J timepoint: 1h drug: Naive	5513075047_C
GSM1187556	RIS_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Risperidone	5513075047_D
GSM1187557	TRA_IV_2 [II]	strain: C57Bl/6J timepoint: 4h drug: Tranylcypromine	5513075047_E
GSM1187558	TWE_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Tween 80	5513075047_F
GSM1187559	HAL_II_2 [II]	strain: C57Bl/6J timepoint: 2h drug: Haloperidol	5513075048_A
GSM1187560	MIA_I_1 [II]	strain: C57Bl/6J timepoint: 1h drug: Mianserin	5513075048_B
GSM1187561	NAI_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Naive	5513075048_C
GSM1187562	SAL_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Saline	5513075048_D
GSM1187563	TRA_II_3 [II]	strain: C57Bl/6J timepoint: 2h drug: Tranylcypromine	5513075048_E
GSM1187564	TWE_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Tween 80	5513075048_F
GSM1187565	BUS_IV_1 [II]	strain: C57Bl/6J timepoint: 4h drug: Buspirone	5513649027_A
GSM1187566	HYD_VIII_3 [II]	strain: C57Bl/6J timepoint: 8h drug: Hydroxizine	5513649027_B
GSM1187567	DIA_I_3 [II]	strain: C57Bl/6J timepoint: 1h drug: Diazepam	5513649027_C
GSM1187568	SAL_IV_5 [II]	strain: C57Bl/6J timepoint: 4h drug: Saline	5513649027_D
GSM1187569	DIA_VIII_2 [II]	strain: C57Bl/6J timepoint: 8h drug: Diazepam	5513649027_E
GSM1187570	HYD_II_1 [II]	strain: C57Bl/6J timepoint: 2h drug: Hydroxizine	a scanning protocol. Description

Platform

GPL6887: Illumina MouseWG-6 v2.0 expression beadchip

Indicator

Areg, Npas4, Cdkn1a, Cirbp, Arc, Egr

Download

Download data in GEO database