Gene symbol: Plaat1

Also known as: A-C1; HRSL1; RLP-2; Hrasls

Organism: Rattus norvegicus

Summary: Enables phospholipase activity. Predicted to be involved in glycerophospholipid metabolic process; lens fiber cell differentiation; and organelle disassembly. Predicted to act upstream of or within ether lipid metabolic process and peroxisome organization. Predicted to be located in several cellular components, including lysosome; nuclear envelope lumen; and peroxisome. Predicted to be active in cytoplasm. Orthologous to human PLAAT1 (phospholipase A and acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 288025 Ensembl:ENSRNOG00000001711 AllianceGenome:RGD:1309485


GO Annotation


Category Term ID Term description
Process GO:0001654 Eye development
Process GO:0002088 Lens development in camera-type eye
Process GO:0006629 Lipid metabolic process
Process GO:0006644 Phospholipid metabolic process
Process GO:0006650 Glycerophospholipid metabolic process
Process GO:0006662 Glycerol ether metabolic process
Process GO:0006793 Phosphorus metabolic process
Process GO:0006796 Phosphate-containing compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006996 Organelle organization
Process GO:0007031 Peroxisome organization
Process GO:0007275 Multicellular organism development
Process GO:0007423 Sensory organ development
Process GO:0008152 Metabolic process
Process GO:0009056 Catabolic process
Process GO:0009888 Tissue development
Process GO:0009987 Cellular process
Process GO:0016042 Lipid catabolic process
Process GO:0016043 Cellular component organization
Process GO:0018904 Ether metabolic process
Process GO:0019637 Organophosphate metabolic process
Process GO:0022411 Cellular component disassembly
Process GO:0030154 Cell differentiation
Process GO:0030855 Epithelial cell differentiation
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0043010 Camera-type eye development
Process GO:0043603 Cellular amide metabolic process
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044255 Cellular lipid metabolic process
Process GO:0044281 Small molecule metabolic process
Process GO:0046337 Phosphatidylethanolamine metabolic process
Process GO:0046470 Phosphatidylcholine metabolic process
Process GO:0046485 Ether lipid metabolic process
Process GO:0046486 Glycerolipid metabolic process
Process GO:0048513 Animal organ development
Process GO:0048731 System development
Process GO:0048856 Anatomical structure development
Process GO:0048869 Cellular developmental process
Process GO:0048880 Sensory system development
Process GO:0060429 Epithelium development
Process GO:0070292 N-acylphosphatidylethanolamine metabolic process
Process GO:0070306 Lens fiber cell differentiation
Process GO:0071704 Organic substance metabolic process
Process GO:0071840 Cellular component organization or biogenesis
Process GO:0150063 Visual system development
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1901575 Organic substance catabolic process
Process GO:1903008 Organelle disassembly
Component GO:0000323 Lytic vacuole
Component GO:0005622 Intracellular anatomical structure
Component GO:0005634 Nucleus
Component GO:0005635 Nuclear envelope
Component GO:0005641 Nuclear envelope lumen
Component GO:0005737 Cytoplasm
Component GO:0005739 Mitochondrion
Component GO:0005764 Lysosome
Component GO:0005773 Vacuole
Component GO:0005777 Peroxisome
Component GO:0005783 Endoplasmic reticulum
Component GO:0005829 Cytosol
Component GO:0012505 Endomembrane system
Component GO:0016020 Membrane
Component GO:0016021 Integral component of membrane
Component GO:0031224 Intrinsic component of membrane
Component GO:0031967 Organelle envelope
Component GO:0031970 Organelle envelope lumen
Component GO:0031974 Membrane-enclosed lumen
Component GO:0031975 Envelope
Component GO:0042579 Microbody
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0043233 Organelle lumen
Component GO:0070013 Intracellular organelle lumen
Component GO:0110165 Cellular anatomical entity
Function GO:0003824 Catalytic activity
Function GO:0004620 Phospholipase activity
Function GO:0004623 Phospholipase A2 activity
Function GO:0008374 O-acyltransferase activity
Function GO:0008970 Phospholipase A1 activity
Function GO:0016298 Lipase activity
Function GO:0016410 N-acyltransferase activity
Function GO:0016740 Transferase activity
Function GO:0016746 Acyltransferase activity
Function GO:0016747 Acyltransferase activity, transferring groups other than amino-acyl groups
Function GO:0016787 Hydrolase activity
Function GO:0016788 Hydrolase activity, acting on ester bonds
Function GO:0052689 Carboxylic ester hydrolase activity
Function GO:0052739 Phosphatidylserine 1-acylhydrolase activity
Function GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity

Pathway annotation


Category Term ID Term description
RCTM RNO-1430728 Metabolism
RCTM RNO-1482839 Acyl chain remodelling of PE
RCTM RNO-1483206 Glycerophospholipid biosynthesis
RCTM RNO-1483257 Phospholipid metabolism
RCTM RNO-556833 Metabolism of lipids

Expression profile of Plaat1 in omics data



ID GSE205202
Title Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM6208507 Rat_Baseline_0h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 6.847059
GSM6208508 Rat_Baseline_0h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.097387
GSM6208509 Rat_Baseline_0h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 6.908181
GSM6208510 Rat_Baseline_0h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.12499
GSM6208511 Rat_Baseline_0h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.287686
GSM6208512 Rat_Vehicle_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 6.826423
GSM6208513 Rat_Vehicle_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 6.950335
GSM6208514 Rat_Vehicle_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 6.908166
GSM6208515 Rat_Vehicle_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 7.078118
GSM6208516 Rat_Vehicle_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 6.943607
GSM6208517 Rat_Vehicle_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.090849
GSM6208518 Rat_Vehicle_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.221718
GSM6208519 Rat_Vehicle_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.066394
GSM6208520 Rat_Vehicle_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 6.971521
GSM6208521 Rat_Vehicle_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.071123
GSM6208522 Rat_Vehicle_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 7.169097
GSM6208523 Rat_Vehicle_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 6.835647
GSM6208524 Rat_Vehicle_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 6.941111
GSM6208525 Rat_Vehicle_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 6.93227
GSM6208526 Rat_Vehicle_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 7.241562
GSM6208527 Rat_Vehicle_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.161004
GSM6208528 Rat_Vehicle_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.053184
GSM6208529 Rat_Vehicle_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 6.971762
GSM6208530 Rat_Vehicle_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.207561
GSM6208531 Rat_Vehicle_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.035469
GSM6208532 Rat_APAP_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 6.883213
GSM6208533 Rat_APAP_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 7.333221
GSM6208534 Rat_APAP_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 6.910772
GSM6208535 Rat_APAP_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 7.06358
GSM6208536 Rat_APAP_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 6.976551
GSM6208537 Rat_APAP_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.6326
GSM6208538 Rat_APAP_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.132815
GSM6208539 Rat_APAP_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.434463
GSM6208540 Rat_APAP_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 6.856761
GSM6208541 Rat_APAP_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.243053
GSM6208542 Rat_APAP_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.156837
GSM6208543 Rat_APAP_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.228369
GSM6208544 Rat_APAP_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.223791
GSM6208545 Rat_APAP_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.060017
GSM6208546 Rat_APAP_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.128877
GSM6208547 Rat_APAP_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.195844
GSM6208548 Rat_APAP_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.3003
GSM6208549 Rat_APAP_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.793328
GSM6208550 Rat_APAP_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.147823
GSM6208551 Rat_APAP_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.466586

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 2.787364
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 4.829358
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 1.580568
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 1.918375