Gene symbol: Ang2

Also known as: Ang; Raa2

Organism: Rattus norvegicus

Summary: Predicted to enable ribonuclease activity. Predicted to be involved in angiogenesis; antimicrobial humoral immune response mediated by antimicrobial peptide; and defense response to other organism. Predicted to act upstream of or within cell growth involved in cardiac muscle cell development; cellular response to glucose stimulus; and positive regulation of protein phosphorylation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in diabetic retinopathy; myocardial infarction; neurodegenerative disease (multiple); and prostate cancer. Orthologous to human ANG (angiogenin). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 497229 Ensembl:ENSRNOG00000025562 AllianceGenome:RGD:1359373


GO Annotation


Category Term ID Term description
Process GO:0001525 Angiogenesis
Process GO:0001568 Blood vessel development
Process GO:0001678 Cellular glucose homeostasis
Process GO:0001932 Regulation of protein phosphorylation
Process GO:0001934 Positive regulation of protein phosphorylation
Process GO:0001944 Vasculature development
Process GO:0002376 Immune system process
Process GO:0003008 System process
Process GO:0003012 Muscle system process
Process GO:0003298 Physiological muscle hypertrophy
Process GO:0003300 Cardiac muscle hypertrophy
Process GO:0003301 Physiological cardiac muscle hypertrophy
Process GO:0006139 Nucleobase-containing compound metabolic process
Process GO:0006725 Cellular aromatic compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006950 Response to stress
Process GO:0006952 Defense response
Process GO:0006955 Immune response
Process GO:0006959 Humoral immune response
Process GO:0007275 Multicellular organism development
Process GO:0007507 Heart development
Process GO:0008152 Metabolic process
Process GO:0009605 Response to external stimulus
Process GO:0009607 Response to biotic stimulus
Process GO:0009612 Response to mechanical stimulus
Process GO:0009617 Response to bacterium
Process GO:0009628 Response to abiotic stimulus
Process GO:0009653 Anatomical structure morphogenesis
Process GO:0009743 Response to carbohydrate
Process GO:0009746 Response to hexose
Process GO:0009749 Response to glucose
Process GO:0009888 Tissue development
Process GO:0009893 Positive regulation of metabolic process
Process GO:0009987 Cellular process
Process GO:0010033 Response to organic substance
Process GO:0010562 Positive regulation of phosphorus metabolic process
Process GO:0010604 Positive regulation of macromolecule metabolic process
Process GO:0014706 Striated muscle tissue development
Process GO:0014896 Muscle hypertrophy
Process GO:0014897 Striated muscle hypertrophy
Process GO:0016049 Cell growth
Process GO:0016070 RNA metabolic process
Process GO:0019220 Regulation of phosphate metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0019725 Cellular homeostasis
Process GO:0019730 Antimicrobial humoral response
Process GO:0019731 Antibacterial humoral response
Process GO:0030154 Cell differentiation
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0031325 Positive regulation of cellular metabolic process
Process GO:0031399 Regulation of protein modification process
Process GO:0031401 Positive regulation of protein modification process
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0033500 Carbohydrate homeostasis
Process GO:0034284 Response to monosaccharide
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0035051 Cardiocyte differentiation
Process GO:0035239 Tube morphogenesis
Process GO:0035265 Organ growth
Process GO:0035295 Tube development
Process GO:0040007 Growth
Process GO:0042221 Response to chemical
Process GO:0042325 Regulation of phosphorylation
Process GO:0042327 Positive regulation of phosphorylation
Process GO:0042592 Homeostatic process
Process GO:0042593 Glucose homeostasis
Process GO:0042692 Muscle cell differentiation
Process GO:0042742 Defense response to bacterium
Process GO:0043170 Macromolecule metabolic process
Process GO:0043207 Response to external biotic stimulus
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044419 Biological process involved in interspecies interaction between organisms
Process GO:0045087 Innate immune response
Process GO:0045937 Positive regulation of phosphate metabolic process
Process GO:0046483 Heterocycle metabolic process
Process GO:0048468 Cell development
Process GO:0048513 Animal organ development
Process GO:0048514 Blood vessel morphogenesis
Process GO:0048518 Positive regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0048588 Developmental cell growth
Process GO:0048589 Developmental growth
Process GO:0048646 Anatomical structure formation involved in morphogenesis
Process GO:0048731 System development
Process GO:0048738 Cardiac muscle tissue development
Process GO:0048856 Anatomical structure development
Process GO:0048869 Cellular developmental process
Process GO:0048878 Chemical homeostasis
Process GO:0050789 Regulation of biological process
Process GO:0050794 Regulation of cellular process
Process GO:0050830 Defense response to Gram-positive bacterium
Process GO:0050896 Response to stimulus
Process GO:0051146 Striated muscle cell differentiation
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051173 Positive regulation of nitrogen compound metabolic process
Process GO:0051174 Regulation of phosphorus metabolic process
Process GO:0051246 Regulation of protein metabolic process
Process GO:0051247 Positive regulation of protein metabolic process
Process GO:0051707 Response to other organism
Process GO:0051716 Cellular response to stimulus
Process GO:0055001 Muscle cell development
Process GO:0055006 Cardiac cell development
Process GO:0055007 Cardiac muscle cell differentiation
Process GO:0055013 Cardiac muscle cell development
Process GO:0055017 Cardiac muscle tissue growth
Process GO:0055082 Cellular chemical homeostasis
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0060419 Heart growth
Process GO:0060537 Muscle tissue development
Process GO:0061049 Cell growth involved in cardiac muscle cell development
Process GO:0061061 Muscle structure development
Process GO:0061844 Antimicrobial humoral immune response mediated by antimicrobial peptide
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0070887 Cellular response to chemical stimulus
Process GO:0071214 Cellular response to abiotic stimulus
Process GO:0071260 Cellular response to mechanical stimulus
Process GO:0071310 Cellular response to organic substance
Process GO:0071322 Cellular response to carbohydrate stimulus
Process GO:0071326 Cellular response to monosaccharide stimulus
Process GO:0071331 Cellular response to hexose stimulus
Process GO:0071333 Cellular response to glucose stimulus
Process GO:0071496 Cellular response to external stimulus
Process GO:0071704 Organic substance metabolic process
Process GO:0072359 Circulatory system development
Process GO:0080090 Regulation of primary metabolic process
Process GO:0090304 Nucleic acid metabolic process
Process GO:0090305 Nucleic acid phosphodiester bond hydrolysis
Process GO:0090501 RNA phosphodiester bond hydrolysis
Process GO:0098542 Defense response to other organism
Process GO:0104004 Cellular response to environmental stimulus
Process GO:1901360 Organic cyclic compound metabolic process
Process GO:1901700 Response to oxygen-containing compound
Process GO:1901701 Cellular response to oxygen-containing compound
Component GO:0005576 Extracellular region
Component GO:0005615 Extracellular space
Component GO:0110165 Cellular anatomical entity
Function GO:0003676 Nucleic acid binding
Function GO:0003824 Catalytic activity
Function GO:0004518 Nuclease activity
Function GO:0004519 Endonuclease activity
Function GO:0004540 Ribonuclease activity
Function GO:0005488 Binding
Function GO:0016787 Hydrolase activity
Function GO:0016788 Hydrolase activity, acting on ester bonds
Function GO:0097159 Organic cyclic compound binding
Function GO:0140098 Catalytic activity, acting on RNA
Function GO:0140640 Catalytic activity, acting on a nucleic acid
Function GO:1901363 Heterocyclic compound binding

Pathway annotation


Category Term ID Term description
RCTM RNO-1500931 Cell-Cell communication
RCTM RNO-418990 Adherens junctions interactions
RCTM RNO-421270 Cell-cell junction organization
RCTM RNO-446728 Cell junction organization
KEGG rno05014 Amyotrophic lateral sclerosis

Expression profile of Ang2 in omics data



ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 1.525540047
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 1.626286587
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 1.654818642
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 1.507444555
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 1.599727742
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 1.558404633

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 4.684158
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 4.8474415
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 4.779572
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.0064910000000005
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 4.79861
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 4.796453

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.0
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.0

ID GSE192399
Title Gene expression of brain regions activated by sevoflurane and propofol
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5746332 LHb, Sevoflurane, 60mins brain region: the lateral habenula (LHb) treatment: Sevoflurane 4.94967
GSM5746333 LHb, O2, 60mins brain region: the lateral habenula (LHb) treatment: O2 5.48044
GSM5746334 MHb, Sevoflurane, 60mins brain region: the medial habenula (MHb) treatment: Sevoflurane 6.09924
GSM5746335 MHb, O2, 60mins brain region: the medial habenula (MHb) treatment: O2 4.97632
GSM5746336 Sol, Sevoflurane, 60mins brain region: the solitary nucleus (Sol) treatment: Sevoflurane 5.26324
GSM5746337 Sol, O2, 60mins brain region: the solitary nucleus (Sol) treatment: O2 5.38465
GSM5746338 Mve, Sevoflurane, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane 4.75186
GSM5746339 Mve, O2, 60mins brain region: the medial vestibular nucleus (MVe) treatment: O2 5.56008
GSM5746340 LHb, Propofol, 60mins brain region: the lateral habenula (LHb) treatment: Propofol 5.16183
GSM5746341 LHb, Intralipos, 60mins brain region: the lateral habenula (LHb) treatment: Intralipos 5.10434
GSM5746342 MHb, Propofol, 60mins brain region: the medial habenula (MHb) treatment: Propofol 5.05914
GSM5746343 MHb, Intralipos, 60mins brain region: the medial habenula (MHb) treatment: Intralipos 5.22306
GSM5746344 Sol, Propofol, 60mins brain region: the solitary nucleus (Sol) treatment: Propofol 5.42156
GSM5746345 Sol, Intralipos, 60mins brain region: the solitary nucleus (Sol) treatment: Intralipos 5.66634
GSM5746346 MVe, Propofol, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Propofol 4.9877
GSM5746347 MVe, Intralipos, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Intralipos 6.25169

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 0.222629
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 0.082316
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 0.220395
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 0.064368