Overview of HIV Mutation, Integration-Cistrome Factor Overlap and Target gene

Human Immunodeficiency Viruses (HIV) are two species of Lentivirus (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. In most cases, HIV is a sexually transmitted infection and occurs by contact with or transfer of blood, pre-ejaculate, semen, and vaginal fluids.
Size: ～9181 nucleotides [RefSeq: NC_001802]
Encoding: RT, PR, IN, Nef and so on
Human Disease: Infection with HIV can lead to HIV/AIDS, AIDS-associated lymphoma, etc. Click here to see all HIV associated human diseases
Drug: The long-term efficacy of drug can induce the emergence of drug resistant virus mutants, some common antiviral drug such as lamivudine, zidovudine, tenofovir, telbivudine, darunavir, raltegravir, enfuvirtide, efavirenz, stavudine, nelfinavir can produce HIV mutants RT.M184V, RT.K103N, RT.K101E, PR.M46I, IN.T97A, etc. Click here to see more HIV drug resistance mutations.

Click the blue font on the page to view detailed information.
The cistrome refers to "the set of cis-acting targets of a trans-acting factor on a genome-wide scale."

HIV Mutation Info

Click here to see all HIV Mutation Sites

ID	PMID	Mutation	Gene/Protein/Region	Description	Detail
1	17311088	Y79F	Gag	G R S I CI C	View
2	17311088	G79F	Gag	G R S I CI C	View
3	17311088	V82I	Gag	G R S I CI C	View
4	17311088	E98D	Nef	G R S I CI C	View
5	30714528	T215F	RT	D G R S CI C	View
6	30714528	T215Y	RT	D G R S CI C	View
7	30714528	T215A	RT	D G R S CI C	View
8	30714528	M41L	RT	G R S CI C	View
9	30714528	D67N	RT	G R S CI C	View
10	30714528	M184V	RT	G R S CI C	View
11	28622345	E138A	RT	D G R S C	View
12	30201008	T280V	Gag	R S I CI C	View
13	30119633	G140A	IN	D G R S C	View
14	30119633	Y143R	IN	D G R S C	View
15	30119633	Q146R	IN	D G R S C	View
16	30119633	H51Y	IN	D G R S C	View
17	30119633	S147G	IN	D G R S C	View
18	30119633	Q148K	IN	D G R S C	View
19	30119633	M50I	IN	D G R S C	View
20	30119633	V151I	IN	D G R S C	View
21	30119633	S153S	IN	D G R S C	View
22	30119633	S153Y	IN	D G R S C	View
23	30119633	S153F	IN	D G R S C	View
24	30119633	S153A	IN	D G R S C	View
25	30119633	M154I	IN	D G R S C	View
26	30119633	N155H	IN	D G R S C	View
27	30119633	E157Q	IN	D G R S C	View
28	30119633	G163R	IN	D G R S C	View
29	30119633	D167E	IN	D G R S C	View
30	30119633	G163G	IN	D G R S C	View
31	30119633	R263R	IN	D G R S C	View
32	30119633	E92E	IN	D G R S C	View
33	30119633	E157K	IN	D G R S C	View
34	30119633	E157E	IN	D G R S C	View
35	30119633	E92G	IN	D G R S C	View
36	30119633	Q148R	IN	D G R S C	View
37	30119633	S17N	IN	D G R S C	View
38	30119633	G140S	IN	D G R S C	View
39	28622345	E138G	RT	D G R S C	View
40	28622345	L23I	PR	D G R S C	View
41	28622345	G190E	RT	D G R S C	View
42	28622345	K238N	RT	D G R S C	View
43	28622345	Q58E	PR	D G R S C	View
44	28622345	V179D	RT	D G R S C	View
45	28622345	V179E	RT	D G R S C	View
46	28622345	K43T	PR	D G R S C	View
47	28622345	M46I	PR	D G R S C	View
48	28622345	K70Q	RT	D G R S C	View
49	28622345	K219R	RT	D G R S C	View
50	30119633	D10E	IN	D G R S C	View
51	30119633	E138E	IN	D G R S C	View
52	30119633	E138K	IN	D G R S C	View
53	30119633	D288N	IN	D G R S C	View
54	30119633	G193E	IN	D G R S C	View
55	30119633	R127K	IN	D G R S C	View
56	30119633	T125A	IN	D G R S C	View
57	30119633	H51H	IN	D G R S C	View
58	30119633	T112V	IN	D G R S C	View
59	30119633	V79I	IN	D G R S C	View
60	30119633	L74M	IN	D G R S C	View
61	30119633	S119R	IN	D G R S C	View
62	30119633	V72I	IN	D G R S C	View
63	30119633	L101I	IN	D G R S C	View
64	30119633	F121Y	IN	D G R S C	View
65	30119633	T66I	IN	D G R S C	View
66	30119633	T66K	IN	D G R S C	View
67	28589513	G190A	RT	D G R S C	View
68	30119633	T97A	IN	D G R S C	View
69	28589513	K103K	RT	D G R S C	View
70	28589513	K103N	RT	D G R S C	View
71	28589513	K101E	RT	D G R S C	View
72	30119633	V201I	IN	D G R S C	View
73	30119633	N232D	IN	D G R S C	View
74	30119633	D232N	IN	D G R S C	View
75	30119633	L234I	IN	D G R S C	View
76	30119633	E92Q	IN	D G R S C	View
77	30119633	Q95R	IN	D G R S C	View
78	30119633	G123S	IN	D G R S C	View
79	30119633	E92V	IN	D G R S C	View
80	30119633	R263K	IN	D G R S C	View
81	32345262	V179E	RT	D G S CI C	View
82	32345262	Y181C	RT	D G S CI C	View
83	32345262	H221Y	RT	D G S CI C	View
84	32345262	E138A	RT	D G S CI C	View
85	32345262	K103R	RT	D G S CI C	View
86	32345262	V179D	RT	D G S CI C	View
87	32300784	Y181C	RT	D G R S C	View
88	32300784	K103N	RT	D G R S C	View
89	32300784	V179E	RT	D G R S C	View
90	32300784	K65R	RT	D G R S C	View
91	32300784	M184V	RT	D G R S C	View
92	32692778	T215Y	RT	D G R S C	View
93	32692778	Y188H	RT	D G R S C	View
94	32692778	P225H	RT	D G R S C	View
95	32692778	K238T	RT	D G R S C	View
96	32692778	M230L	RT	D G R S C	View
97	32692778	V179E	RT	D G R S C	View
98	32692778	E138G	RT	D G R S C	View
99	32692778	E138A	RT	D G R S C	View
100	32692778	K103N	RT	D G R S C	View

HIV Overlap Info between Viral Integration Fragments and Cistrome Factors

Click to see statistics heatmap of VIS-Factor Overlap in the human genome of HIV

Click to see histogram of VIS-Factor Overlap by chromosome of HIV

Click to see the overlap count of three factors and HIV intergration fragments on the human chromosomes

Only show 100 info Click here to see all HIV Integration Sites

DVID	Chromosome	Histone Modification	Transcription Factor Binding Site	Chromatin Accessibility	Sum of Overlapped Records	Detail
4000003	chr1	1945	2399	1988	6332	View
4500020	chr1	3317	1850	1137	6304	View
4000024	chr1	2302	115	5	2422	View
4000044	chr1	1187	134	359	1680	View
4000049	chr1	1078	96	442	1616	View
4000072	chr1	1205	97	13	1315	View
4000079	chr1	430	382	448	1260	View
4000088	chr1	1162	11		1173	View
4000090	chr1	119	473	573	1165	View
4000094	chr1	932	66	146	1144	View
4000122	chr1	763	75	151	989	View
4000141	chr1	237	322	356	915	View
4000143	chr1	882	18		900	View
4000152	chr1	792	58	21	871	View
4000153	chr1	700	81	84	865	View
4000155	chr1	855	5	2	862	View
4000179	chr1	664	101	46	811	View
4000196	chr1	75	432	253	760	View
4000199	chr1	594	67	94	755	View
4000201	chr1	498	132	122	752	View
4000231	chr1	106	505	73	684	View
4000245	chr1	560	18	73	651	View
4000246	chr1	33	271	347	651	View
4000255	chr1	430	123	84	637	View
4000259	chr1	252	205	176	633	View
4000262	chr1	202	280	144	626	View
4000284	chr1	7	489	96	592	View
4000291	chr1	170	322	89	581	View
4000295	chr1	190	208	177	575	View
4000305	chr1	334	149	78	561	View
4000329	chr1	409	66	55	530	View
4000333	chr1	231	174	124	529	View
4000360	chr1	477	33	8	518	View
4000363	chr1	259	98	158	515	View
4000385	chr1	347	97	54	498	View
4000414	chr1	11	426	45	482	View
4000426	chr1	170	140	161	471	View
4000438	chr1	449	11	3	463	View
4000452	chr1	257	125	72	454	View
4000461	chr1	409	31	7	447	View
4000472	chr1	392	31	15	438	View
4000488	chr1	410	9	10	429	View
4000504	chr1	379	29	8	416	View
4000513	chr1	172	56	179	407	View
4000514	chr1	321	66	20	407	View
4000518	chr1	59	129	216	404	View
4000534	chr1	318	48	23	389	View
4000549	chr1	121	74	192	387	View
4000556	chr1	254	51	68	373	View
4000570	chr1	228	123	14	365	View
4000577	chr1	329	33	1	363	View
4000595	chr1	144	39	176	359	View
4000608	chr1	327	14	3	344	View
4000609	chr1	237	23	83	343	View
4000618	chr1	44	277	20	341	View
4000639	chr1	317	18		335	View
4000653	chr1	5	230	96	331	View
4000659	chr1	313	14	1	328	View
4000688	chr1	191	47	79	317	View
4000693	chr1	108	80	127	315	View
4000695	chr1	81	155	78	314	View
4000709	chr1	291	16	2	309	View
4000714	chr1	178	32	97	307	View
4000722	chr1	142	148	13	303	View
4000734	chr1	102	136	61	299	View
4500019	chr1	83	122	85	290	View
4000765	chr1	177	35	75	287	View
4000788	chr1	123	146	15	284	View
4000781	chr1	58	103	122	283	View
4000784	chr1	270	13		283	View
4000807	chr1	77	61	138	276	View
4000808	chr1	75	101	99	275	View
4000824	chr1	143	93	36	272	View
4000837	chr1	265	3		268	View
4000842	chr1	29	221	17	267	View
4000869	chr1	190	37	34	261	View
4000872	chr1	44	92	124	260	View
4000877	chr1	246	8	3	257	View
4000879	chr1	194	54	8	256	View
4000898	chr1	222	31		253	View
4000900	chr1	231	21	1	253	View
4000901	chr1	168	73	12	253	View
4000913	chr1	192	40	19	251	View
4000905	chr1	234	11	5	250	View
4000938	chr1	67	82	96	245	View
4000941	chr1	61	88	94	243	View
4000942	chr1	41	140	61	242	View
4000946	chr1	9	215	17	241	View
4000967	chr1	4	47	186	237	View
4000971	chr1	207	11	19	237	View
4000975	chr1	127	62	47	236	View
4000985	chr1	181	50	1	232	View
4000986	chr1	94	40	98	232	View
4000994	chr1	144	80	6	230	View
4001005	chr1	11	130	89	230	View
4001010	chr1	115	81	33	229	View
4001026	chr1	145	43	40	228	View
4001053	chr1	92	51	81	224	View
4001069	chr1	38	163	20	221	View
4001079	chr1	83	64	71	218	View

HIV Target Gene Info

Click to see correlation between gene expression and proportions of infiltrating immune cells of HIV

ID	Target gene	Virus	Gene Function	Literature Count	Detail
1	TP53BP1	HIV	Suppressor gene	1	View
2	ZNF292	HIV	Suppressor gene	2	View
3	TANK	HIV	Suppressor gene	2	View
4	ZBTB4	HIV	Suppressor gene	1	View
5	VPS53	HIV	Suppressor gene	1	View
6	TOM1L2	HIV	Suppressor gene	1	View
7	VDR	HIV	Suppressor gene	1	View
8	SYNPO2	HIV	Suppressor gene	1	View
9	SSBP2	HIV	Suppressor gene	1	View
10	UVRAG	HIV	Suppressor gene	3	View
11	ZMYND11	HIV	Suppressor gene	1	View
12	TRIM3	HIV	Suppressor gene	1	View
13	ST13	HIV	Suppressor gene	2	View
14	TRIM35	HIV	Suppressor gene	1	View
15	TNFRSF10B	HIV	Suppressor gene	1	View
16	TNFRSF10A	HIV	Suppressor gene	1	View
17	ZHX2	HIV	Suppressor gene	1	View
18	TRIT1	HIV	Suppressor gene	3	View
19	SUFU	HIV	Suppressor gene	2	View
20	WWOX	HIV	Suppressor gene	3	View
21	USP12	HIV	Suppressor gene	1	View
22	TSC1	HIV	Suppressor gene	1	View
23	TSC2	HIV	Suppressor gene	1	View
24	TSC22D1	HIV	Suppressor gene	1	View
25	ZFP82	HIV	Suppressor gene	1	View
26	XAF1	HIV	Suppressor gene	4	View
27	TES	HIV	Suppressor gene	1	View
28	UBE4B	HIV	Suppressor gene	4	View
29	TSG101	HIV	Suppressor gene	1	View
30	XPO5	HIV	Suppressor gene	1	View
31	STRADA	HIV	Suppressor gene	2	View
32	UIMC1	HIV	Suppressor gene	1	View
33	UHRF2	HIV	Suppressor gene	1	View
34	XRCC5	HIV	Suppressor gene	1	View
35	STAT1	HIV	Suppressor gene	1	View
36	UFL1	HIV	Suppressor gene	1	View
37	TGFBR2	HIV	Suppressor gene	3	View
38	STK11	HIV	Suppressor gene	2	View
39	STK10	HIV	Suppressor gene	2	View
40	ZDHHC2	HIV	Suppressor gene	1	View
41	TGFBR3	HIV	Suppressor gene	2	View
42	TTF1	HIV	Suppressor gene	1	View
43	RBM4	HIV	Suppressor gene	2	View
44	PIAS1	HIV	Suppressor gene	2	View
45	PHF6	HIV	Suppressor gene	1	View
46	PHC3	HIV	Suppressor gene	2	View
47	PHACTR4	HIV	Suppressor gene	4	View
48	PIWIL2	HIV	Suppressor gene	1	View
49	PKNOX1	HIV	Suppressor gene	1	View
50	PLA2R1	HIV	Suppressor gene	1	View
51	PLAAT4	HIV	Suppressor gene	2	View
52	PLD1	HIV	Suppressor gene	1	View
53	PPARA	HIV	Suppressor gene	1	View
54	PDSS2	HIV	Suppressor gene	1	View
55	PPP2CA	HIV	Suppressor gene	1	View
56	PPP2R5C	HIV	Suppressor gene	3	View
57	PPP3CC	HIV	Suppressor gene	2	View
58	PRDM1	HIV	Suppressor gene	1	View
59	PRDM2	HIV	Suppressor gene	4	View
60	PRKAA1	HIV	Suppressor gene	1	View
61	PRKAR1A	HIV	Suppressor gene	1	View
62	PDS5B	HIV	Suppressor gene	2	View
63	PRKCB	HIV	Suppressor gene	3	View
64	PRKN	HIV	Suppressor gene	1	View
65	NDST4	HIV	Suppressor gene	1	View
66	PDCD4	HIV	Suppressor gene	1	View
67	PTEN	HIV	Suppressor gene	2	View
68	NF1	HIV	Suppressor gene	4	View
69	NF2	HIV	Suppressor gene	1	View
70	PTPN1	HIV	Suppressor gene	1	View
71	PTPN12	HIV	Suppressor gene	1	View
72	PTPN13	HIV	Suppressor gene	2	View
73	PTPN2	HIV	Suppressor gene	1	View
74	PTPN23	HIV	Suppressor gene	2	View
75	PTPRC	HIV	Suppressor gene	1	View
76	PTPRD	HIV	Suppressor gene	1	View
77	PTPRK	HIV	Suppressor gene	1	View
78	PTPRT	HIV	Suppressor gene	1	View
79	PCDH9	HIV	Suppressor gene	2	View
80	NFATC2	HIV	Suppressor gene	2	View
81	PCDH17	HIV	Suppressor gene	1	View
82	PBRM1	HIV	Suppressor gene	1	View
83	RAB7A	HIV	Suppressor gene	3	View
84	RACK1	HIV	Suppressor gene	1	View
85	RAD23B	HIV	Suppressor gene	1	View
86	RAD51C	HIV	Suppressor gene	1	View
87	PARP1	HIV	Suppressor gene	1	View
88	RANBP9	HIV	Suppressor gene	1	View
89	RASSF3	HIV	Suppressor gene	2	View
90	RASSF5	HIV	Suppressor gene	1	View
91	RB1	HIV	Suppressor gene	2	View
92	RB1CC1	HIV	Suppressor gene	1	View
93	RBL1	HIV	Suppressor gene	4	View
94	RBL2	HIV	Suppressor gene	2	View
95	PAFAH1B1	HIV	Suppressor gene	2	View
96	RBM5	HIV	Suppressor gene	3	View
97	RBM6	HIV	Suppressor gene	2	View
98	RBMS3	HIV	Suppressor gene	1	View
99	RCHY1	HIV	Suppressor gene	1	View
100	NFKB1	HIV	Suppressor gene	3	View


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