Gene symbol: Grk2

Also known as: BARK1; GRK-2; Adrbk1

Organism: Rattus norvegicus

Summary: Enables several functions, including opioid receptor binding activity; protein kinase activity; and scaffold protein binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of G protein-coupled receptor signaling pathway; and negative regulation of cellular protein metabolic process. Located in several cellular components, including basolateral plasma membrane; caveola; and dendrite. Used to study hyperglycemia; impotence; and limb ischemia. Biomarker of Parkinson's disease; congestive heart failure; hypertension; and portal hypertension. Orthologous to human GRK2 (G protein-coupled receptor kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 25238 Ensembl:ENSRNOG00000018985 AllianceGenome:RGD:2062


GO Annotation


Category Term ID Term description
Process GO:0000003 Reproduction
Process GO:0000302 Response to reactive oxygen species
Process GO:0001541 Ovarian follicle development
Process GO:0001678 Cellular glucose homeostasis
Process GO:0001817 Regulation of cytokine production
Process GO:0001819 Positive regulation of cytokine production
Process GO:0001932 Regulation of protein phosphorylation
Process GO:0001933 Negative regulation of protein phosphorylation
Process GO:0002026 Regulation of the force of heart contraction
Process GO:0002029 Desensitization of G protein-coupled receptor signaling pathway
Process GO:0003006 Developmental process involved in reproduction
Process GO:0003008 System process
Process GO:0003012 Muscle system process
Process GO:0003013 Circulatory system process
Process GO:0003015 Heart process
Process GO:0003018 Vascular process in circulatory system
Process GO:0003057 Regulation of the force of heart contraction by chemical signal
Process GO:0003108 Negative regulation of the force of heart contraction by chemical signal
Process GO:0006468 Protein phosphorylation
Process GO:0006793 Phosphorus metabolic process
Process GO:0006796 Phosphate-containing compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006810 Transport
Process GO:0006897 Endocytosis
Process GO:0006898 Receptor-mediated endocytosis
Process GO:0006936 Muscle contraction
Process GO:0006937 Regulation of muscle contraction
Process GO:0006941 Striated muscle contraction
Process GO:0006942 Regulation of striated muscle contraction
Process GO:0006950 Response to stress
Process GO:0006979 Response to oxidative stress
Process GO:0007154 Cell communication
Process GO:0007165 Signal transduction
Process GO:0007186 G protein-coupled receptor signaling pathway
Process GO:0007217 Tachykinin receptor signaling pathway
Process GO:0007275 Multicellular organism development
Process GO:0007399 Nervous system development
Process GO:0007417 Central nervous system development
Process GO:0007507 Heart development
Process GO:0007548 Sex differentiation
Process GO:0007568 Aging
Process GO:0008015 Blood circulation
Process GO:0008016 Regulation of heart contraction
Process GO:0008104 Protein localization
Process GO:0008152 Metabolic process
Process GO:0008277 Regulation of G protein-coupled receptor signaling pathway
Process GO:0008284 Positive regulation of cell population proliferation
Process GO:0008406 Gonad development
Process GO:0008585 Female gonad development
Process GO:0009605 Response to external stimulus
Process GO:0009719 Response to endogenous stimulus
Process GO:0009725 Response to hormone
Process GO:0009743 Response to carbohydrate
Process GO:0009746 Response to hexose
Process GO:0009749 Response to glucose
Process GO:0009892 Negative regulation of metabolic process
Process GO:0009893 Positive regulation of metabolic process
Process GO:0009966 Regulation of signal transduction
Process GO:0009967 Positive regulation of signal transduction
Process GO:0009968 Negative regulation of signal transduction
Process GO:0009987 Cellular process
Process GO:0009991 Response to extracellular stimulus
Process GO:0010001 Glial cell differentiation
Process GO:0010033 Response to organic substance
Process GO:0010035 Response to inorganic substance
Process GO:0010243 Response to organonitrogen compound
Process GO:0010466 Negative regulation of peptidase activity
Process GO:0010468 Regulation of gene expression
Process GO:0010563 Negative regulation of phosphorus metabolic process
Process GO:0010604 Positive regulation of macromolecule metabolic process
Process GO:0010605 Negative regulation of macromolecule metabolic process
Process GO:0010628 Positive regulation of gene expression
Process GO:0010646 Regulation of cell communication
Process GO:0010647 Positive regulation of cell communication
Process GO:0010648 Negative regulation of cell communication
Process GO:0010660 Regulation of muscle cell apoptotic process
Process GO:0010661 Positive regulation of muscle cell apoptotic process
Process GO:0010799 Regulation of peptidyl-threonine phosphorylation
Process GO:0010801 Negative regulation of peptidyl-threonine phosphorylation
Process GO:0010827 Regulation of glucose transmembrane transport
Process GO:0010829 Negative regulation of glucose transmembrane transport
Process GO:0010941 Regulation of cell death
Process GO:0010942 Positive regulation of cell death
Process GO:0010951 Negative regulation of endopeptidase activity
Process GO:0014070 Response to organic cyclic compound
Process GO:0014072 Response to isoquinoline alkaloid
Process GO:0014823 Response to activity
Process GO:0014850 Response to muscle activity
Process GO:0016032 Viral process
Process GO:0016192 Vesicle-mediated transport
Process GO:0016310 Phosphorylation
Process GO:0018105 Peptidyl-serine phosphorylation
Process GO:0018107 Peptidyl-threonine phosphorylation
Process GO:0018193 Peptidyl-amino acid modification
Process GO:0018209 Peptidyl-serine modification
Process GO:0018210 Peptidyl-threonine modification
Process GO:0019058 Viral life cycle
Process GO:0019079 Viral genome replication
Process GO:0019220 Regulation of phosphate metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0019229 Regulation of vasoconstriction
Process GO:0019538 Protein metabolic process
Process GO:0019725 Cellular homeostasis
Process GO:0022008 Neurogenesis
Process GO:0022401 Negative adaptation of signaling pathway
Process GO:0022412 Cellular process involved in reproduction in multicellular organism
Process GO:0022414 Reproductive process
Process GO:0022602 Ovulation cycle process
Process GO:0023051 Regulation of signaling
Process GO:0023052 Signaling
Process GO:0023056 Positive regulation of signaling
Process GO:0023057 Negative regulation of signaling
Process GO:0023058 Adaptation of signaling pathway
Process GO:0030154 Cell differentiation
Process GO:0030162 Regulation of proteolysis
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0031324 Negative regulation of cellular metabolic process
Process GO:0031399 Regulation of protein modification process
Process GO:0031400 Negative regulation of protein modification process
Process GO:0031623 Receptor internalization
Process GO:0031644 Regulation of nervous system process
Process GO:0031646 Positive regulation of nervous system process
Process GO:0031667 Response to nutrient levels
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0032504 Multicellular organism reproduction
Process GO:0032507 Maintenance of protein location in cell
Process GO:0032675 Regulation of interleukin-6 production
Process GO:0032755 Positive regulation of interleukin-6 production
Process GO:0032879 Regulation of localization
Process GO:0033036 Macromolecule localization
Process GO:0033135 Regulation of peptidyl-serine phosphorylation
Process GO:0033137 Negative regulation of peptidyl-serine phosphorylation
Process GO:0033365 Protein localization to organelle
Process GO:0033500 Carbohydrate homeostasis
Process GO:0033605 Positive regulation of catecholamine secretion
Process GO:0033993 Response to lipid
Process GO:0034097 Response to cytokine
Process GO:0034284 Response to monosaccharide
Process GO:0034504 Protein localization to nucleus
Process GO:0034762 Regulation of transmembrane transport
Process GO:0034763 Negative regulation of transmembrane transport
Process GO:0035150 Regulation of tube size
Process GO:0035296 Regulation of tube diameter
Process GO:0036211 Protein modification process
Process GO:0042063 Gliogenesis
Process GO:0042127 Regulation of cell population proliferation
Process GO:0042221 Response to chemical
Process GO:0042311 Vasodilation
Process GO:0042325 Regulation of phosphorylation
Process GO:0042326 Negative regulation of phosphorylation
Process GO:0042391 Regulation of membrane potential
Process GO:0042542 Response to hydrogen peroxide
Process GO:0042592 Homeostatic process
Process GO:0042593 Glucose homeostasis
Process GO:0042698 Ovulation cycle
Process GO:0042699 Follicle-stimulating hormone signaling pathway
Process GO:0042981 Regulation of apoptotic process
Process GO:0043065 Positive regulation of apoptotic process
Process GO:0043066 Negative regulation of apoptotic process
Process GO:0043067 Regulation of programmed cell death
Process GO:0043068 Positive regulation of programmed cell death
Process GO:0043069 Negative regulation of programmed cell death
Process GO:0043086 Negative regulation of catalytic activity
Process GO:0043170 Macromolecule metabolic process
Process GO:0043278 Response to morphine
Process GO:0043279 Response to alkaloid
Process GO:0043412 Macromolecule modification
Process GO:0044000 Movement in host
Process GO:0044057 Regulation of system process
Process GO:0044092 Negative regulation of molecular function
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044321 Response to leptin
Process GO:0044403 Biological process involved in symbiotic interaction
Process GO:0044409 Entry into host
Process GO:0044419 Biological process involved in interspecies interaction between organisms
Process GO:0045137 Development of primary sexual characteristics
Process GO:0045185 Maintenance of protein location
Process GO:0045472 Response to ether
Process GO:0045744 Negative regulation of G protein-coupled receptor signaling pathway
Process GO:0045822 Negative regulation of heart contraction
Process GO:0045861 Negative regulation of proteolysis
Process GO:0045907 Positive regulation of vasoconstriction
Process GO:0045932 Negative regulation of muscle contraction
Process GO:0045936 Negative regulation of phosphate metabolic process
Process GO:0045988 Negative regulation of striated muscle contraction
Process GO:0046324 Regulation of glucose import
Process GO:0046325 Negative regulation of glucose import
Process GO:0046545 Development of primary female sexual characteristics
Process GO:0046660 Female sex differentiation
Process GO:0046718 Viral entry into host cell
Process GO:0048145 Regulation of fibroblast proliferation
Process GO:0048146 Positive regulation of fibroblast proliferation
Process GO:0048511 Rhythmic process
Process GO:0048513 Animal organ development
Process GO:0048518 Positive regulation of biological process
Process GO:0048519 Negative regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0048523 Negative regulation of cellular process
Process GO:0048583 Regulation of response to stimulus
Process GO:0048584 Positive regulation of response to stimulus
Process GO:0048585 Negative regulation of response to stimulus
Process GO:0048608 Reproductive structure development
Process GO:0048609 Multicellular organismal reproductive process
Process GO:0048660 Regulation of smooth muscle cell proliferation
Process GO:0048661 Positive regulation of smooth muscle cell proliferation
Process GO:0048709 Oligodendrocyte differentiation
Process GO:0048731 System development
Process GO:0048856 Anatomical structure development
Process GO:0048869 Cellular developmental process
Process GO:0048878 Chemical homeostasis
Process GO:0050433 Regulation of catecholamine secretion
Process GO:0050789 Regulation of biological process
Process GO:0050790 Regulation of catalytic activity
Process GO:0050794 Regulation of cellular process
Process GO:0050804 Modulation of chemical synaptic transmission
Process GO:0050896 Response to stimulus
Process GO:0051046 Regulation of secretion
Process GO:0051047 Positive regulation of secretion
Process GO:0051049 Regulation of transport
Process GO:0051050 Positive regulation of transport
Process GO:0051051 Negative regulation of transport
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051172 Negative regulation of nitrogen compound metabolic process
Process GO:0051174 Regulation of phosphorus metabolic process
Process GO:0051179 Localization
Process GO:0051234 Establishment of localization
Process GO:0051235 Maintenance of location
Process GO:0051239 Regulation of multicellular organismal process
Process GO:0051240 Positive regulation of multicellular organismal process
Process GO:0051241 Negative regulation of multicellular organismal process
Process GO:0051246 Regulation of protein metabolic process
Process GO:0051248 Negative regulation of protein metabolic process
Process GO:0051336 Regulation of hydrolase activity
Process GO:0051346 Negative regulation of hydrolase activity
Process GO:0051457 Maintenance of protein location in nucleus
Process GO:0051641 Cellular localization
Process GO:0051651 Maintenance of location in cell
Process GO:0051701 Biological process involved in interaction with host
Process GO:0051716 Cellular response to stimulus
Process GO:0051930 Regulation of sensory perception of pain
Process GO:0051931 Regulation of sensory perception
Process GO:0051952 Regulation of amine transport
Process GO:0051954 Positive regulation of amine transport
Process GO:0052547 Regulation of peptidase activity
Process GO:0052548 Regulation of endopeptidase activity
Process GO:0055082 Cellular chemical homeostasis
Process GO:0060047 Heart contraction
Process GO:0060048 Cardiac muscle contraction
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0060548 Negative regulation of cell death
Process GO:0061458 Reproductive system development
Process GO:0061771 Response to caloric restriction
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0065009 Regulation of molecular function
Process GO:0070727 Cellular macromolecule localization
Process GO:0070848 Response to growth factor
Process GO:0070849 Response to epidermal growth factor
Process GO:0070887 Cellular response to chemical stimulus
Process GO:0071310 Cellular response to organic substance
Process GO:0071322 Cellular response to carbohydrate stimulus
Process GO:0071326 Cellular response to monosaccharide stimulus
Process GO:0071331 Cellular response to hexose stimulus
Process GO:0071333 Cellular response to glucose stimulus
Process GO:0071345 Cellular response to cytokine stimulus
Process GO:0071362 Cellular response to ether
Process GO:0071363 Cellular response to growth factor stimulus
Process GO:0071364 Cellular response to epidermal growth factor stimulus
Process GO:0071396 Cellular response to lipid
Process GO:0071407 Cellular response to organic cyclic compound
Process GO:0071417 Cellular response to organonitrogen compound
Process GO:0071495 Cellular response to endogenous stimulus
Process GO:0071704 Organic substance metabolic process
Process GO:0071867 Response to monoamine
Process GO:0071868 Cellular response to monoamine stimulus
Process GO:0071869 Response to catecholamine
Process GO:0071870 Cellular response to catecholamine stimulus
Process GO:0072359 Circulatory system development
Process GO:0072595 Maintenance of protein localization in organelle
Process GO:0072752 Cellular response to rapamycin
Process GO:0080090 Regulation of primary metabolic process
Process GO:0090066 Regulation of anatomical structure size
Process GO:0090257 Regulation of muscle system process
Process GO:0097305 Response to alcohol
Process GO:0097306 Cellular response to alcohol
Process GO:0097746 Blood vessel diameter maintenance
Process GO:0098815 Modulation of excitatory postsynaptic potential
Process GO:0099177 Regulation of trans-synaptic signaling
Process GO:0106070 Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
Process GO:0106072 Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
Process GO:1900076 Regulation of cellular response to insulin stimulus
Process GO:1900077 Negative regulation of cellular response to insulin stimulus
Process GO:1901077 Regulation of relaxation of muscle
Process GO:1901078 Negative regulation of relaxation of muscle
Process GO:1901080 Regulation of relaxation of smooth muscle
Process GO:1901081 Negative regulation of relaxation of smooth muscle
Process GO:1901355 Response to rapamycin
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1901654 Response to ketone
Process GO:1901655 Cellular response to ketone
Process GO:1901698 Response to nitrogen compound
Process GO:1901699 Cellular response to nitrogen compound
Process GO:1901700 Response to oxygen-containing compound
Process GO:1901701 Cellular response to oxygen-containing compound
Process GO:1903522 Regulation of blood circulation
Process GO:1903523 Negative regulation of blood circulation
Process GO:1903530 Regulation of secretion by cell
Process GO:1903532 Positive regulation of secretion by cell
Process GO:1904058 Positive regulation of sensory perception of pain
Process GO:1904627 Response to phorbol 13-acetate 12-myristate
Process GO:1904628 Cellular response to phorbol 13-acetate 12-myristate
Process GO:1904705 Regulation of vascular associated smooth muscle cell proliferation
Process GO:1904707 Positive regulation of vascular associated smooth muscle cell proliferation
Process GO:1990868 Response to chemokine
Process GO:1990869 Cellular response to chemokine
Process GO:2000116 Regulation of cysteine-type endopeptidase activity
Process GO:2000117 Negative regulation of cysteine-type endopeptidase activity
Process GO:2000463 Positive regulation of excitatory postsynaptic potential
Component GO:0005622 Intracellular anatomical structure
Component GO:0005634 Nucleus
Component GO:0005737 Cytoplasm
Component GO:0005739 Mitochondrion
Component GO:0005829 Cytosol
Component GO:0005886 Plasma membrane
Component GO:0005901 Caveola
Component GO:0009925 Basal plasma membrane
Component GO:0016020 Membrane
Component GO:0016323 Basolateral plasma membrane
Component GO:0016324 Apical plasma membrane
Component GO:0030054 Cell junction
Component GO:0030424 Axon
Component GO:0030425 Dendrite
Component GO:0036477 Somatodendritic compartment
Component GO:0042995 Cell projection
Component GO:0043005 Neuron projection
Component GO:0043197 Dendritic spine
Component GO:0043198 Dendritic shaft
Component GO:0043226 Organelle
Component GO:0043227 Membrane-bounded organelle
Component GO:0043229 Intracellular organelle
Component GO:0043231 Intracellular membrane-bounded organelle
Component GO:0044309 Neuron spine
Component GO:0044853 Plasma membrane raft
Component GO:0045121 Membrane raft
Component GO:0045177 Apical part of cell
Component GO:0045178 Basal part of cell
Component GO:0045202 Synapse
Component GO:0070161 Anchoring junction
Component GO:0071944 Cell periphery
Component GO:0097447 Dendritic tree
Component GO:0098590 Plasma membrane region
Component GO:0098793 Presynapse
Component GO:0098794 Postsynapse
Component GO:0098857 Membrane microdomain
Component GO:0110165 Cellular anatomical entity
Component GO:0120025 Plasma membrane bounded cell projection
Function GO:0000166 Nucleotide binding
Function GO:0001664 G protein-coupled receptor binding
Function GO:0003824 Catalytic activity
Function GO:0004672 Protein kinase activity
Function GO:0004674 Protein serine/threonine kinase activity
Function GO:0004703 G protein-coupled receptor kinase activity
Function GO:0005102 Signaling receptor binding
Function GO:0005488 Binding
Function GO:0005515 Protein binding
Function GO:0005524 ATP binding
Function GO:0016301 Kinase activity
Function GO:0016740 Transferase activity
Function GO:0016772 Transferase activity, transferring phosphorus-containing groups
Function GO:0016773 Phosphotransferase activity, alcohol group as acceptor
Function GO:0017076 Purine nucleotide binding
Function GO:0019899 Enzyme binding
Function GO:0030554 Adenyl nucleotide binding
Function GO:0031625 Ubiquitin protein ligase binding
Function GO:0031628 Opioid receptor binding
Function GO:0031753 Endothelial differentiation G protein-coupled receptor binding
Function GO:0031755 Edg-2 lysophosphatidic acid receptor binding
Function GO:0031850 Delta-type opioid receptor binding
Function GO:0031851 Kappa-type opioid receptor binding
Function GO:0032553 Ribonucleotide binding
Function GO:0032555 Purine ribonucleotide binding
Function GO:0032559 Adenyl ribonucleotide binding
Function GO:0035639 Purine ribonucleoside triphosphate binding
Function GO:0036094 Small molecule binding
Function GO:0043167 Ion binding
Function GO:0043168 Anion binding
Function GO:0044389 Ubiquitin-like protein ligase binding
Function GO:0047696 Beta-adrenergic receptor kinase activity
Function GO:0097110 Scaffold protein binding
Function GO:0097159 Organic cyclic compound binding
Function GO:0097367 Carbohydrate derivative binding
Function GO:0140096 Catalytic activity, acting on a protein
Function GO:1901265 Nucleoside phosphate binding
Function GO:1901363 Heterocyclic compound binding

Pathway annotation


Category Term ID Term description
RCTM RNO-111885 Opioid Signalling
RCTM RNO-111933 Calmodulin induced events
RCTM RNO-111996 Ca-dependent events
RCTM RNO-111997 CaM pathway
RCTM RNO-112040 G-protein mediated events
RCTM RNO-112043 PLC beta mediated events
RCTM RNO-1489509 DAG and IP3 signaling
RCTM RNO-162582 Signal Transduction
RCTM RNO-199991 Membrane Trafficking
RCTM RNO-372790 Signaling by GPCR
RCTM RNO-388396 GPCR downstream signalling
RCTM RNO-416476 G alpha (q) signalling events
RCTM RNO-418555 G alpha (s) signalling events
RCTM RNO-418594 G alpha (i) signalling events
RCTM RNO-5358351 Signaling by Hedgehog
RCTM RNO-5632684 Hedgehog on state
RCTM RNO-5635838 Activation of SMO
RCTM RNO-5653656 Vesicle-mediated transport
RCTM RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
RCTM RNO-8856828 Clathrin-mediated endocytosis
RCTM RNO-9006925 Intracellular signaling by second messengers
KEGG rno04062 Chemokine signaling pathway
KEGG rno04144 Endocytosis
KEGG rno04340 Hedgehog signaling pathway
KEGG rno04724 Glutamatergic synapse
KEGG rno04740 Olfactory transduction
KEGG rno05032 Morphine addiction

Expression profile of Grk2 in omics data



ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 94.55
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 103.153
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 93.616
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 92.667
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 91.498

ID GSE205202
Title Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM6208507 Rat_Baseline_0h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.333345
GSM6208508 Rat_Baseline_0h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.288018
GSM6208509 Rat_Baseline_0h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.353506
GSM6208510 Rat_Baseline_0h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.254212
GSM6208511 Rat_Baseline_0h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 7.324845
GSM6208512 Rat_Vehicle_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 7.456734
GSM6208513 Rat_Vehicle_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 7.341234
GSM6208514 Rat_Vehicle_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 7.3941
GSM6208515 Rat_Vehicle_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 7.330554
GSM6208516 Rat_Vehicle_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 7.323123
GSM6208517 Rat_Vehicle_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.256627
GSM6208518 Rat_Vehicle_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.442706
GSM6208519 Rat_Vehicle_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.250549
GSM6208520 Rat_Vehicle_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.219433
GSM6208521 Rat_Vehicle_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 7.330031
GSM6208522 Rat_Vehicle_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 7.345393
GSM6208523 Rat_Vehicle_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 7.436165
GSM6208524 Rat_Vehicle_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 7.269439
GSM6208525 Rat_Vehicle_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 7.262141
GSM6208526 Rat_Vehicle_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 7.288534
GSM6208527 Rat_Vehicle_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.285187
GSM6208528 Rat_Vehicle_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.035282
GSM6208529 Rat_Vehicle_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.233222
GSM6208530 Rat_Vehicle_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.040455
GSM6208531 Rat_Vehicle_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 7.375078
GSM6208532 Rat_APAP_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 7.332725
GSM6208533 Rat_APAP_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 7.180859
GSM6208534 Rat_APAP_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 7.271695
GSM6208535 Rat_APAP_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 7.158528
GSM6208536 Rat_APAP_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 7.075779
GSM6208537 Rat_APAP_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.761667
GSM6208538 Rat_APAP_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.786552
GSM6208539 Rat_APAP_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.484016
GSM6208540 Rat_APAP_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.755763
GSM6208541 Rat_APAP_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 7.564911
GSM6208542 Rat_APAP_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.49531
GSM6208543 Rat_APAP_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.875335
GSM6208544 Rat_APAP_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.711893
GSM6208545 Rat_APAP_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.69712
GSM6208546 Rat_APAP_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 7.719381
GSM6208547 Rat_APAP_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.217088
GSM6208548 Rat_APAP_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.200413
GSM6208549 Rat_APAP_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.4943
GSM6208550 Rat_APAP_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.034382
GSM6208551 Rat_APAP_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 7.241524

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 22.287086
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 22.97604
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 18.095718
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 19.770617

ID GSE2982
Title Effect of inhaled anesthetic to cultured cortical neurons
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM61779 Cell Culture Exposure (control1) Cy3 label;Cy5; 0.0946
GSM61796 Cell Culture Exposure (control2) Cy3; Cy5 0.168
GSM61797 Cell Culture Exposure (control3) Cy3; Cy5 0.162
GSM61798 Cell Culture Exposure (1MAC Halo1) Cy3; Cy5 -0.187
GSM61799 Cell Culture Exposure (1MAC Halo2) Cy3; Cy5 0.0318
GSM61800 Cell Culture Exposure (1MAC Halo3) Cy3; Cy5 0.0433
GSM61801 Cell Culture Exposure (3MAC Halo1) Cy3; Cy5 0.239
GSM61802 Cell Culture Exposure (3MAC Halo2) Cy3; Cy5 0.418
GSM61803 Cell Culture Exposure (3MAC Halo3) Cy3; Cy5 0.159
GSM61804 Cell Culture Exposure (3MAC ISO1) Cy3; Cy5 0.262
GSM61805 Cell Culture Exposure (3MAC ISO2) Cy3; Cy5 0.0544
GSM61806 Cell Culture Exposure (3MAC ISO3) Cy3; Cy5 0.4

ID GSE53897
Title Genome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1303240 DRG RVM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.967339
GSM1303241 DRG RVM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.951279
GSM1303242 DRG RVM3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 7.116464
GSM1303243 DRG RVM7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.551659
GSM1303244 DRG RVOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.738492
GSM1303245 DRG RVOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.974922
GSM1303246 DRG RVOx5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.827538
GSM1303247 DRG RVOx7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.973161
GSM1303248 DRG RVS4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 7.135793
GSM1303249 DRG RVS5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.925575
GSM1303250 DRG RVS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.872558
GSM1303251 DRG RVS7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.995778
GSM1303252 DRG RSM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.942483
GSM1303253 DRG RSM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.913371
GSM1303254 DRG RSM4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.877531
GSM1303255 DRG RSM5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.975445
GSM1303256 DRG RSOx1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.85998
GSM1303257 DRG RSOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 7.062908
GSM1303258 DRG RSOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.674104
GSM1303259 DRG RSOx4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 7.092688
GSM1303260 DRG RSS1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.746151
GSM1303261 DRG RSS2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 7.189582
GSM1303262 DRG RSS3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.773601
GSM1303263 DRG RSS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.989717