Gene symbol: Wnt3a

Organism: Rattus norvegicus

Summary: Predicted to enable several functions, including co-receptor binding activity; signaling receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including canonical Wnt signaling pathway involved in heart development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of macromolecule metabolic process. Predicted to be located in cell surface. Predicted to be part of Wnt-Frizzled-LRP5/6 complex. Predicted to be active in extracellular space and glutamatergic synapse. Biomarker of hypothyroidism. Orthologous to human WNT3A (Wnt family member 3A). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 303181 Ensembl:ENSRNOG00000003039 AllianceGenome:RGD:1308057


GO Annotation


Category Term ID Term description
Process GO:0000902 Cell morphogenesis
Process GO:0000904 Cell morphogenesis involved in differentiation
Process GO:0001503 Ossification
Process GO:0001558 Regulation of cell growth
Process GO:0001649 Osteoblast differentiation
Process GO:0001701 In utero embryonic development
Process GO:0001704 Formation of primary germ layer
Process GO:0001707 Mesoderm formation
Process GO:0001710 Mesodermal cell fate commitment
Process GO:0001756 Somitogenesis
Process GO:0001775 Cell activation
Process GO:0001817 Regulation of cytokine production
Process GO:0001819 Positive regulation of cytokine production
Process GO:0001932 Regulation of protein phosphorylation
Process GO:0001934 Positive regulation of protein phosphorylation
Process GO:0001947 Heart looping
Process GO:0002009 Morphogenesis of an epithelium
Process GO:0002090 Regulation of receptor internalization
Process GO:0002092 Positive regulation of receptor internalization
Process GO:0002376 Immune system process
Process GO:0002520 Immune system development
Process GO:0002682 Regulation of immune system process
Process GO:0002684 Positive regulation of immune system process
Process GO:0002694 Regulation of leukocyte activation
Process GO:0002696 Positive regulation of leukocyte activation
Process GO:0003002 Regionalization
Process GO:0003007 Heart morphogenesis
Process GO:0003143 Embryonic heart tube morphogenesis
Process GO:0003156 Regulation of animal organ formation
Process GO:0003306 Wnt signaling pathway involved in heart development
Process GO:0003401 Axis elongation
Process GO:0006139 Nucleobase-containing compound metabolic process
Process GO:0006351 Transcription, DNA-templated
Process GO:0006355 Regulation of transcription, DNA-templated
Process GO:0006357 Regulation of transcription by RNA polymerase II
Process GO:0006366 Transcription by RNA polymerase II
Process GO:0006725 Cellular aromatic compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0006810 Transport
Process GO:0006811 Ion transport
Process GO:0006812 Cation transport
Process GO:0006816 Calcium ion transport
Process GO:0006935 Chemotaxis
Process GO:0006950 Response to stress
Process GO:0007154 Cell communication
Process GO:0007155 Cell adhesion
Process GO:0007165 Signal transduction
Process GO:0007166 Cell surface receptor signaling pathway
Process GO:0007267 Cell-cell signaling
Process GO:0007275 Multicellular organism development
Process GO:0007368 Determination of left/right symmetry
Process GO:0007369 Gastrulation
Process GO:0007389 Pattern specification process
Process GO:0007399 Nervous system development
Process GO:0007405 Neuroblast proliferation
Process GO:0007409 Axonogenesis
Process GO:0007411 Axon guidance
Process GO:0007417 Central nervous system development
Process GO:0007420 Brain development
Process GO:0007423 Sensory organ development
Process GO:0007498 Mesoderm development
Process GO:0007507 Heart development
Process GO:0007517 Muscle organ development
Process GO:0007519 Skeletal muscle tissue development
Process GO:0007596 Blood coagulation
Process GO:0007599 Hemostasis
Process GO:0008104 Protein localization
Process GO:0008152 Metabolic process
Process GO:0008283 Cell population proliferation
Process GO:0008284 Positive regulation of cell population proliferation
Process GO:0008361 Regulation of cell size
Process GO:0009058 Biosynthetic process
Process GO:0009059 Macromolecule biosynthetic process
Process GO:0009605 Response to external stimulus
Process GO:0009611 Response to wounding
Process GO:0009653 Anatomical structure morphogenesis
Process GO:0009790 Embryo development
Process GO:0009792 Embryo development ending in birth or egg hatching
Process GO:0009799 Specification of symmetry
Process GO:0009855 Determination of bilateral symmetry
Process GO:0009887 Animal organ morphogenesis
Process GO:0009888 Tissue development
Process GO:0009889 Regulation of biosynthetic process
Process GO:0009891 Positive regulation of biosynthetic process
Process GO:0009893 Positive regulation of metabolic process
Process GO:0009952 Anterior/posterior pattern specification
Process GO:0009953 Dorsal/ventral pattern formation
Process GO:0009966 Regulation of signal transduction
Process GO:0009967 Positive regulation of signal transduction
Process GO:0009987 Cellular process
Process GO:0009996 Negative regulation of cell fate specification
Process GO:0010387 COP9 signalosome assembly
Process GO:0010453 Regulation of cell fate commitment
Process GO:0010454 Negative regulation of cell fate commitment
Process GO:0010455 Positive regulation of cell fate commitment
Process GO:0010467 Gene expression
Process GO:0010468 Regulation of gene expression
Process GO:0010556 Regulation of macromolecule biosynthetic process
Process GO:0010557 Positive regulation of macromolecule biosynthetic process
Process GO:0010562 Positive regulation of phosphorus metabolic process
Process GO:0010604 Positive regulation of macromolecule metabolic process
Process GO:0010628 Positive regulation of gene expression
Process GO:0010646 Regulation of cell communication
Process GO:0010647 Positive regulation of cell communication
Process GO:0010720 Positive regulation of cell development
Process GO:0010721 Negative regulation of cell development
Process GO:0010941 Regulation of cell death
Process GO:0010950 Positive regulation of endopeptidase activity
Process GO:0010952 Positive regulation of peptidase activity
Process GO:0010975 Regulation of neuron projection development
Process GO:0010977 Negative regulation of neuron projection development
Process GO:0014706 Striated muscle tissue development
Process GO:0016043 Cellular component organization
Process GO:0016055 Wnt signaling pathway
Process GO:0016070 RNA metabolic process
Process GO:0017145 Stem cell division
Process GO:0018130 Heterocycle biosynthetic process
Process GO:0019219 Regulation of nucleobase-containing compound metabolic process
Process GO:0019220 Regulation of phosphate metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0019438 Aromatic compound biosynthetic process
Process GO:0021510 Spinal cord development
Process GO:0021515 Cell differentiation in spinal cord
Process GO:0021516 Dorsal spinal cord development
Process GO:0021527 Spinal cord association neuron differentiation
Process GO:0021532 Neural tube patterning
Process GO:0021537 Telencephalon development
Process GO:0021543 Pallium development
Process GO:0021761 Limbic system development
Process GO:0021766 Hippocampus development
Process GO:0021846 Cell proliferation in forebrain
Process GO:0021872 Forebrain generation of neurons
Process GO:0021873 Forebrain neuroblast division
Process GO:0021874 Wnt signaling pathway involved in forebrain neuroblast division
Process GO:0021904 Dorsal/ventral neural tube patterning
Process GO:0021915 Neural tube development
Process GO:0021953 Central nervous system neuron differentiation
Process GO:0022008 Neurogenesis
Process GO:0022407 Regulation of cell-cell adhesion
Process GO:0022409 Positive regulation of cell-cell adhesion
Process GO:0022603 Regulation of anatomical structure morphogenesis
Process GO:0022607 Cellular component assembly
Process GO:0023051 Regulation of signaling
Process GO:0023052 Signaling
Process GO:0023056 Positive regulation of signaling
Process GO:0030001 Metal ion transport
Process GO:0030030 Cell projection organization
Process GO:0030097 Hemopoiesis
Process GO:0030100 Regulation of endocytosis
Process GO:0030111 Regulation of Wnt signaling pathway
Process GO:0030154 Cell differentiation
Process GO:0030155 Regulation of cell adhesion
Process GO:0030162 Regulation of proteolysis
Process GO:0030168 Platelet activation
Process GO:0030177 Positive regulation of Wnt signaling pathway
Process GO:0030182 Neuron differentiation
Process GO:0030198 Extracellular matrix organization
Process GO:0030307 Positive regulation of cell growth
Process GO:0030308 Negative regulation of cell growth
Process GO:0030516 Regulation of axon extension
Process GO:0030517 Negative regulation of axon extension
Process GO:0030879 Mammary gland development
Process GO:0030888 Regulation of B cell proliferation
Process GO:0030890 Positive regulation of B cell proliferation
Process GO:0030900 Forebrain development
Process GO:0030901 Midbrain development
Process GO:0031175 Neuron projection development
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0031325 Positive regulation of cellular metabolic process
Process GO:0031326 Regulation of cellular biosynthetic process
Process GO:0031328 Positive regulation of cellular biosynthetic process
Process GO:0031344 Regulation of cell projection organization
Process GO:0031345 Negative regulation of cell projection organization
Process GO:0031346 Positive regulation of cell projection organization
Process GO:0031399 Regulation of protein modification process
Process GO:0031401 Positive regulation of protein modification process
Process GO:0032092 Positive regulation of protein binding
Process GO:0032101 Regulation of response to external stimulus
Process GO:0032102 Negative regulation of response to external stimulus
Process GO:0032501 Multicellular organismal process
Process GO:0032502 Developmental process
Process GO:0032535 Regulation of cellular component size
Process GO:0032774 RNA biosynthetic process
Process GO:0032879 Regulation of localization
Process GO:0032880 Regulation of protein localization
Process GO:0032886 Regulation of microtubule-based process
Process GO:0032943 Mononuclear cell proliferation
Process GO:0032944 Regulation of mononuclear cell proliferation
Process GO:0032946 Positive regulation of mononuclear cell proliferation
Process GO:0032989 Cellular component morphogenesis
Process GO:0032990 Cell part morphogenesis
Process GO:0033036 Macromolecule localization
Process GO:0033043 Regulation of organelle organization
Process GO:0033135 Regulation of peptidyl-serine phosphorylation
Process GO:0033138 Positive regulation of peptidyl-serine phosphorylation
Process GO:0033278 Cell proliferation in midbrain
Process GO:0033674 Positive regulation of kinase activity
Process GO:0034109 Homotypic cell-cell adhesion
Process GO:0034220 Ion transmembrane transport
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0034654 Nucleobase-containing compound biosynthetic process
Process GO:0035050 Embryonic heart tube development
Process GO:0035051 Cardiocyte differentiation
Process GO:0035239 Tube morphogenesis
Process GO:0035282 Segmentation
Process GO:0035295 Tube development
Process GO:0035914 Skeletal muscle cell differentiation
Process GO:0036342 Post-anal tail morphogenesis
Process GO:0040007 Growth
Process GO:0040008 Regulation of growth
Process GO:0040011 Locomotion
Process GO:0040012 Regulation of locomotion
Process GO:0040013 Negative regulation of locomotion
Process GO:0040019 Positive regulation of embryonic development
Process GO:0042060 Wound healing
Process GO:0042100 B cell proliferation
Process GO:0042113 B cell activation
Process GO:0042127 Regulation of cell population proliferation
Process GO:0042221 Response to chemical
Process GO:0042325 Regulation of phosphorylation
Process GO:0042327 Positive regulation of phosphorylation
Process GO:0042330 Taxis
Process GO:0042471 Ear morphogenesis
Process GO:0042472 Inner ear morphogenesis
Process GO:0042659 Regulation of cell fate specification
Process GO:0042660 Positive regulation of cell fate specification
Process GO:0042661 Regulation of mesodermal cell fate specification
Process GO:0042692 Muscle cell differentiation
Process GO:0042693 Muscle cell fate commitment
Process GO:0043009 Chordate embryonic development
Process GO:0043062 Extracellular structure organization
Process GO:0043085 Positive regulation of catalytic activity
Process GO:0043170 Macromolecule metabolic process
Process GO:0043280 Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Process GO:0043281 Regulation of cysteine-type endopeptidase activity involved in apoptotic process
Process GO:0043393 Regulation of protein binding
Process GO:0043549 Regulation of kinase activity
Process GO:0043583 Ear development
Process GO:0043933 Protein-containing complex organization
Process GO:0044085 Cellular component biogenesis
Process GO:0044087 Regulation of cellular component biogenesis
Process GO:0044093 Positive regulation of molecular function
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044249 Cellular biosynthetic process
Process GO:0044271 Cellular nitrogen compound biosynthetic process
Process GO:0045165 Cell fate commitment
Process GO:0045229 External encapsulating structure organization
Process GO:0045321 Leukocyte activation
Process GO:0045444 Fat cell differentiation
Process GO:0045445 Myoblast differentiation
Process GO:0045595 Regulation of cell differentiation
Process GO:0045596 Negative regulation of cell differentiation
Process GO:0045597 Positive regulation of cell differentiation
Process GO:0045598 Regulation of fat cell differentiation
Process GO:0045599 Negative regulation of fat cell differentiation
Process GO:0045664 Regulation of neuron differentiation
Process GO:0045665 Negative regulation of neuron differentiation
Process GO:0045785 Positive regulation of cell adhesion
Process GO:0045807 Positive regulation of endocytosis
Process GO:0045859 Regulation of protein kinase activity
Process GO:0045860 Positive regulation of protein kinase activity
Process GO:0045862 Positive regulation of proteolysis
Process GO:0045893 Positive regulation of transcription, DNA-templated
Process GO:0045926 Negative regulation of growth
Process GO:0045927 Positive regulation of growth
Process GO:0045935 Positive regulation of nucleobase-containing compound metabolic process
Process GO:0045937 Positive regulation of phosphate metabolic process
Process GO:0045944 Positive regulation of transcription by RNA polymerase II
Process GO:0045995 Regulation of embryonic development
Process GO:0046483 Heterocycle metabolic process
Process GO:0046649 Lymphocyte activation
Process GO:0046651 Lymphocyte proliferation
Process GO:0048103 Somatic stem cell division
Process GO:0048259 Regulation of receptor-mediated endocytosis
Process GO:0048260 Positive regulation of receptor-mediated endocytosis
Process GO:0048332 Mesoderm morphogenesis
Process GO:0048333 Mesodermal cell differentiation
Process GO:0048339 Paraxial mesoderm development
Process GO:0048340 Paraxial mesoderm morphogenesis
Process GO:0048341 Paraxial mesoderm formation
Process GO:0048342 Paraxial mesodermal cell differentiation
Process GO:0048343 Paraxial mesodermal cell fate commitment
Process GO:0048468 Cell development
Process GO:0048513 Animal organ development
Process GO:0048518 Positive regulation of biological process
Process GO:0048519 Negative regulation of biological process
Process GO:0048522 Positive regulation of cellular process
Process GO:0048523 Negative regulation of cellular process
Process GO:0048534 Hematopoietic or lymphoid organ development
Process GO:0048562 Embryonic organ morphogenesis
Process GO:0048568 Embryonic organ development
Process GO:0048583 Regulation of response to stimulus
Process GO:0048584 Positive regulation of response to stimulus
Process GO:0048585 Negative regulation of response to stimulus
Process GO:0048589 Developmental growth
Process GO:0048598 Embryonic morphogenesis
Process GO:0048638 Regulation of developmental growth
Process GO:0048639 Positive regulation of developmental growth
Process GO:0048640 Negative regulation of developmental growth
Process GO:0048641 Regulation of skeletal muscle tissue development
Process GO:0048643 Positive regulation of skeletal muscle tissue development
Process GO:0048646 Anatomical structure formation involved in morphogenesis
Process GO:0048666 Neuron development
Process GO:0048667 Cell morphogenesis involved in neuron differentiation
Process GO:0048670 Regulation of collateral sprouting
Process GO:0048672 Positive regulation of collateral sprouting
Process GO:0048696 Regulation of collateral sprouting in absence of injury
Process GO:0048697 Positive regulation of collateral sprouting in absence of injury
Process GO:0048699 Generation of neurons
Process GO:0048729 Tissue morphogenesis
Process GO:0048731 System development
Process GO:0048732 Gland development
Process GO:0048738 Cardiac muscle tissue development
Process GO:0048812 Neuron projection morphogenesis
Process GO:0048839 Inner ear development
Process GO:0048841 Regulation of axon extension involved in axon guidance
Process GO:0048843 Negative regulation of axon extension involved in axon guidance
Process GO:0048856 Anatomical structure development
Process GO:0048858 Cell projection morphogenesis
Process GO:0048869 Cellular developmental process
Process GO:0050670 Regulation of lymphocyte proliferation
Process GO:0050671 Positive regulation of lymphocyte proliferation
Process GO:0050678 Regulation of epithelial cell proliferation
Process GO:0050679 Positive regulation of epithelial cell proliferation
Process GO:0050730 Regulation of peptidyl-tyrosine phosphorylation
Process GO:0050731 Positive regulation of peptidyl-tyrosine phosphorylation
Process GO:0050767 Regulation of neurogenesis
Process GO:0050768 Negative regulation of neurogenesis
Process GO:0050769 Positive regulation of neurogenesis
Process GO:0050770 Regulation of axonogenesis
Process GO:0050771 Negative regulation of axonogenesis
Process GO:0050772 Positive regulation of axonogenesis
Process GO:0050789 Regulation of biological process
Process GO:0050790 Regulation of catalytic activity
Process GO:0050793 Regulation of developmental process
Process GO:0050794 Regulation of cellular process
Process GO:0050803 Regulation of synapse structure or activity
Process GO:0050804 Modulation of chemical synaptic transmission
Process GO:0050807 Regulation of synapse organization
Process GO:0050817 Coagulation
Process GO:0050864 Regulation of B cell activation
Process GO:0050865 Regulation of cell activation
Process GO:0050867 Positive regulation of cell activation
Process GO:0050871 Positive regulation of B cell activation
Process GO:0050878 Regulation of body fluid levels
Process GO:0050896 Response to stimulus
Process GO:0050920 Regulation of chemotaxis
Process GO:0050922 Negative regulation of chemotaxis
Process GO:0051049 Regulation of transport
Process GO:0051050 Positive regulation of transport
Process GO:0051090 Regulation of DNA-binding transcription factor activity
Process GO:0051091 Positive regulation of DNA-binding transcription factor activity
Process GO:0051093 Negative regulation of developmental process
Process GO:0051094 Positive regulation of developmental process
Process GO:0051098 Regulation of binding
Process GO:0051099 Positive regulation of binding
Process GO:0051128 Regulation of cellular component organization
Process GO:0051129 Negative regulation of cellular component organization
Process GO:0051130 Positive regulation of cellular component organization
Process GO:0051146 Striated muscle cell differentiation
Process GO:0051147 Regulation of muscle cell differentiation
Process GO:0051149 Positive regulation of muscle cell differentiation
Process GO:0051153 Regulation of striated muscle cell differentiation
Process GO:0051155 Positive regulation of striated muscle cell differentiation
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051173 Positive regulation of nitrogen compound metabolic process
Process GO:0051174 Regulation of phosphorus metabolic process
Process GO:0051179 Localization
Process GO:0051234 Establishment of localization
Process GO:0051239 Regulation of multicellular organismal process
Process GO:0051240 Positive regulation of multicellular organismal process
Process GO:0051241 Negative regulation of multicellular organismal process
Process GO:0051246 Regulation of protein metabolic process
Process GO:0051247 Positive regulation of protein metabolic process
Process GO:0051249 Regulation of lymphocyte activation
Process GO:0051251 Positive regulation of lymphocyte activation
Process GO:0051252 Regulation of RNA metabolic process
Process GO:0051254 Positive regulation of RNA metabolic process
Process GO:0051301 Cell division
Process GO:0051336 Regulation of hydrolase activity
Process GO:0051338 Regulation of transferase activity
Process GO:0051345 Positive regulation of hydrolase activity
Process GO:0051347 Positive regulation of transferase activity
Process GO:0051493 Regulation of cytoskeleton organization
Process GO:0051641 Cellular localization
Process GO:0051716 Cellular response to stimulus
Process GO:0051890 Regulation of cardioblast differentiation
Process GO:0051892 Negative regulation of cardioblast differentiation
Process GO:0051960 Regulation of nervous system development
Process GO:0051961 Negative regulation of nervous system development
Process GO:0051962 Positive regulation of nervous system development
Process GO:0051963 Regulation of synapse assembly
Process GO:0052547 Regulation of peptidase activity
Process GO:0052548 Regulation of endopeptidase activity
Process GO:0055007 Cardiac muscle cell differentiation
Process GO:0055057 Neuroblast division
Process GO:0055085 Transmembrane transport
Process GO:0060021 Roof of mouth development
Process GO:0060070 Canonical Wnt signaling pathway
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0060284 Regulation of cell development
Process GO:0060322 Head development
Process GO:0060341 Regulation of cellular localization
Process GO:0060429 Epithelium development
Process GO:0060485 Mesenchyme development
Process GO:0060537 Muscle tissue development
Process GO:0060538 Skeletal muscle organ development
Process GO:0060548 Negative regulation of cell death
Process GO:0060560 Developmental growth involved in morphogenesis
Process GO:0060562 Epithelial tube morphogenesis
Process GO:0060627 Regulation of vesicle-mediated transport
Process GO:0060795 Cell fate commitment involved in formation of primary germ layer
Process GO:0060828 Regulation of canonical Wnt signaling pathway
Process GO:0060911 Cardiac cell fate commitment
Process GO:0060923 Cardiac muscle cell fate commitment
Process GO:0061053 Somite development
Process GO:0061061 Muscle structure development
Process GO:0061097 Regulation of protein tyrosine kinase activity
Process GO:0061098 Positive regulation of protein tyrosine kinase activity
Process GO:0061183 Regulation of dermatome development
Process GO:0061184 Positive regulation of dermatome development
Process GO:0061311 Cell surface receptor signaling pathway involved in heart development
Process GO:0061316 Canonical Wnt signaling pathway involved in heart development
Process GO:0061317 Canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
Process GO:0061351 Neural precursor cell proliferation
Process GO:0061371 Determination of heart left/right asymmetry
Process GO:0061387 Regulation of extent of cell growth
Process GO:0061564 Axon development
Process GO:0062009 Secondary palate development
Process GO:0065003 Protein-containing complex assembly
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0065009 Regulation of molecular function
Process GO:0070507 Regulation of microtubule cytoskeleton organization
Process GO:0070527 Platelet aggregation
Process GO:0070588 Calcium ion transmembrane transport
Process GO:0070661 Leukocyte proliferation
Process GO:0070663 Regulation of leukocyte proliferation
Process GO:0070665 Positive regulation of leukocyte proliferation
Process GO:0070727 Cellular macromolecule localization
Process GO:0071704 Organic substance metabolic process
Process GO:0071840 Cellular component organization or biogenesis
Process GO:0072132 Mesenchyme morphogenesis
Process GO:0072359 Circulatory system development
Process GO:0080090 Regulation of primary metabolic process
Process GO:0090066 Regulation of anatomical structure size
Process GO:0090245 Axis elongation involved in somitogenesis
Process GO:0090263 Positive regulation of canonical Wnt signaling pathway
Process GO:0090304 Nucleic acid metabolic process
Process GO:0090381 Regulation of heart induction
Process GO:0090596 Sensory organ morphogenesis
Process GO:0097485 Neuron projection guidance
Process GO:0097659 Nucleic acid-templated transcription
Process GO:0098609 Cell-cell adhesion
Process GO:0098655 Cation transmembrane transport
Process GO:0098660 Inorganic ion transmembrane transport
Process GO:0098662 Inorganic cation transmembrane transport
Process GO:0098926 Postsynaptic signal transduction
Process GO:0099174 Regulation of presynapse organization
Process GO:0099177 Regulation of trans-synaptic signaling
Process GO:0099527 Postsynapse to nucleus signaling pathway
Process GO:0099536 Synaptic signaling
Process GO:0120035 Regulation of plasma membrane bounded cell projection organization
Process GO:0120036 Plasma membrane bounded cell projection organization
Process GO:0120039 Plasma membrane bounded cell projection morphogenesis
Process GO:0198738 Cell-cell signaling by wnt
Process GO:1901214 Regulation of neuron death
Process GO:1901215 Negative regulation of neuron death
Process GO:1901360 Organic cyclic compound metabolic process
Process GO:1901362 Organic cyclic compound biosynthetic process
Process GO:1901576 Organic substance biosynthetic process
Process GO:1901861 Regulation of muscle tissue development
Process GO:1901863 Positive regulation of muscle tissue development
Process GO:1901888 Regulation of cell junction assembly
Process GO:1902680 Positive regulation of RNA biosynthetic process
Process GO:1903076 Regulation of protein localization to plasma membrane
Process GO:1903078 Positive regulation of protein localization to plasma membrane
Process GO:1903506 Regulation of nucleic acid-templated transcription
Process GO:1903508 Positive regulation of nucleic acid-templated transcription
Process GO:1903829 Positive regulation of protein localization
Process GO:1904338 Regulation of dopaminergic neuron differentiation
Process GO:1904339 Negative regulation of dopaminergic neuron differentiation
Process GO:1904375 Regulation of protein localization to cell periphery
Process GO:1904377 Positive regulation of protein localization to cell periphery
Process GO:1905114 Cell surface receptor signaling pathway involved in cell-cell signaling
Process GO:1905207 Regulation of cardiocyte differentiation
Process GO:1905208 Negative regulation of cardiocyte differentiation
Process GO:1905209 Positive regulation of cardiocyte differentiation
Process GO:1905475 Regulation of protein localization to membrane
Process GO:1905477 Positive regulation of protein localization to membrane
Process GO:1905606 Regulation of presynapse assembly
Process GO:1905770 Regulation of mesodermal cell differentiation
Process GO:1905772 Positive regulation of mesodermal cell differentiation
Process GO:2000026 Regulation of multicellular organismal development
Process GO:2000027 Regulation of animal organ morphogenesis
Process GO:2000043 Regulation of cardiac cell fate specification
Process GO:2000047 Regulation of cell-cell adhesion mediated by cadherin
Process GO:2000049 Positive regulation of cell-cell adhesion mediated by cadherin
Process GO:2000079 Regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
Process GO:2000116 Regulation of cysteine-type endopeptidase activity
Process GO:2000177 Regulation of neural precursor cell proliferation
Process GO:2000179 Positive regulation of neural precursor cell proliferation
Process GO:2000345 Regulation of hepatocyte proliferation
Process GO:2000347 Positive regulation of hepatocyte proliferation
Process GO:2000725 Regulation of cardiac muscle cell differentiation
Process GO:2000727 Positive regulation of cardiac muscle cell differentiation
Process GO:2000736 Regulation of stem cell differentiation
Process GO:2000737 Negative regulation of stem cell differentiation
Process GO:2000826 Regulation of heart morphogenesis
Process GO:2001056 Positive regulation of cysteine-type endopeptidase activity
Process GO:2001141 Regulation of RNA biosynthetic process
Process GO:0003136 Negative regulation of heart induction by canonical Wnt signaling pathway
Process GO:0009997 Negative regulation of cardioblast cell fate specification
Process GO:0042686 Regulation of cardioblast cell fate specification
Process GO:0048337 Positive regulation of mesodermal cell fate specification
Process GO:0090676 Calcium ion transmembrane transport via low voltage-gated calcium channel
Process GO:0100012 Regulation of heart induction by canonical Wnt signaling pathway
Process GO:1901320 Negative regulation of heart induction
Process GO:2000044 Negative regulation of cardiac cell fate specification
Process GO:2000081 Positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation
Component GO:0005576 Extracellular region
Component GO:0005615 Extracellular space
Component GO:0005886 Plasma membrane
Component GO:0009986 Cell surface
Component GO:0016020 Membrane
Component GO:0030054 Cell junction
Component GO:0032991 Protein-containing complex
Component GO:0045202 Synapse
Component GO:0071944 Cell periphery
Component GO:0098796 Membrane protein complex
Component GO:0098797 Plasma membrane protein complex
Component GO:0098978 Glutamatergic synapse
Component GO:0110165 Cellular anatomical entity
Component GO:1990851 Wnt-Frizzled-LRP5/6 complex
Function GO:0001664 G protein-coupled receptor binding
Function GO:0003712 Transcription coregulator activity
Function GO:0003713 Transcription coactivator activity
Function GO:0005102 Signaling receptor binding
Function GO:0005109 Frizzled binding
Function GO:0005125 Cytokine activity
Function GO:0005488 Binding
Function GO:0005515 Protein binding
Function GO:0019904 Protein domain specific binding
Function GO:0030545 Signaling receptor regulator activity
Function GO:0030546 Signaling receptor activator activity
Function GO:0039706 Co-receptor binding
Function GO:0048018 Receptor ligand activity
Function GO:0098772 Molecular function regulator activity
Function GO:0140110 Transcription regulator activity

Pathway annotation


Category Term ID Term description
RCTM RNO-162582 Signal Transduction
RCTM RNO-195721 Signaling by WNT
RCTM RNO-201681 TCF dependent signaling in response to WNT
RCTM RNO-3238698 WNT ligand biogenesis and trafficking
RCTM RNO-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
RCTM RNO-4641263 Regulation of FZD by ubiquitination
WikiPathways WP1288 Wnt signaling pathway and pluripotency
WikiPathways WP375 Wnt signaling pathway
KEGG rno04150 mTOR signaling pathway
KEGG rno04310 Wnt signaling pathway
KEGG rno04390 Hippo signaling pathway
KEGG rno04550 Signaling pathways regulating pluripotency of stem cells
KEGG rno04916 Melanogenesis
KEGG rno04934 Cushing syndrome
KEGG rno05010 Alzheimer disease
KEGG rno05022 Pathways of neurodegeneration - multiple diseases
KEGG rno05165 Human papillomavirus infection
KEGG rno05200 Pathways in cancer
KEGG rno05205 Proteoglycans in cancer
KEGG rno05206 MicroRNAs in cancer
KEGG rno05217 Basal cell carcinoma
KEGG rno05224 Breast cancer
KEGG rno05225 Hepatocellular carcinoma
KEGG rno05226 Gastric cancer

Expression profile of Wnt3a in omics data



ID GSE100499
Title Exploring acupuncture mechanism in preconditioning of IRI
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM2685201 MX1 tissue: Myocardium gender: male 3.4561303
GSM2685202 MX2 tissue: Myocardium gender: female 3.1944056
GSM2685203 MX3 tissue: Myocardium gender: female 3.8126009
GSM2685204 MX4 tissue: Myocardium gender: male 3.7980518
GSM2685205 DZ1 tissue: Myocardium gender: male 4.1215525
GSM2685206 DZ2 tissue: Myocardium gender: male 3.0756466
GSM2685207 DZ3 tissue: Myocardium gender: female 4.0852532
GSM2685208 DZ4 tissue: Myocardium gender: female 3.7394507
GSM2685209 JJ1 tissue: Myocardium gender: male 3.7064908
GSM2685210 JJ2 tissue: Myocardium gender: female 4.589791
GSM2685211 JJ3 tissue: Myocardium gender: female 4.5739303
GSM2685212 JJ4 tissue: Myocardium gender: male 4.2925835
GSM2685213 NG1 tissue: Myocardium gender: male 4.387362
GSM2685214 NG2 tissue: Myocardium gender: female 4.124036
GSM2685215 NG3 tissue: Myocardium gender: male 3.4662194
GSM2685216 NG4 tissue: Myocardium gender: female 3.9235675
GSM2685217 YL1 tissue: Myocardium gender: male 2.3701637
GSM2685218 YL2 tissue: Myocardium gender: male 4.0457845
GSM2685219 YL3 tissue: Myocardium gender: female 3.5984564
GSM2685220 YL4 tissue: Myocardium gender: female 2.5710938
GSM2685221 QC1 tissue: Myocardium gender: male 3.593905
GSM2685222 QC2 tissue: Myocardium gender: male 4.4168115
GSM2685223 QC3 tissue: Myocardium gender: female 4.2306457
GSM2685224 QC4 tissue: Myocardium gender: female 4.2664104

ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.979467915
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.005851314
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 2.88208462
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.028655766
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.050589051
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 3.094452577

ID GSE138454
Title Impact of inflammation on hepatic subcellular energetics in anesthetized rats
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4108997 Sample 1 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4108998 Sample 2 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4108999 Sample 3 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109000 Sample 4 Isoflurane sepsis anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109001 Sample 5 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109002 Sample 6 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109003 Sample 7 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109004 Sample 8 Isoflurane control anesthetic background: Isoflurane strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109005 Sample9 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109006 Sample10 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109007 Sample11 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109008 Sample12 Propofol sepsis anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: sepsis gender: male 0.0
GSM4109009 Sample13 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109010 Sample14 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109011 Sample 15 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0
GSM4109012 Sample16 Propofol control anesthetic background: Propofol strain: Sprague-Dawley age: 10 weeks old sepsis/control: control gender: male 0.0

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.627091
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.626693
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 5.576748
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 6.076905
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.702284
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 5.530142

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 0.0
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.0
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 0.0

ID GSE192399
Title Gene expression of brain regions activated by sevoflurane and propofol
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM5746332 LHb, Sevoflurane, 60mins brain region: the lateral habenula (LHb) treatment: Sevoflurane 3.15234
GSM5746333 LHb, O2, 60mins brain region: the lateral habenula (LHb) treatment: O2 3.10618
GSM5746334 MHb, Sevoflurane, 60mins brain region: the medial habenula (MHb) treatment: Sevoflurane 3.36532
GSM5746335 MHb, O2, 60mins brain region: the medial habenula (MHb) treatment: O2 3.22326
GSM5746336 Sol, Sevoflurane, 60mins brain region: the solitary nucleus (Sol) treatment: Sevoflurane 3.12018
GSM5746337 Sol, O2, 60mins brain region: the solitary nucleus (Sol) treatment: O2 3.28768
GSM5746338 Mve, Sevoflurane, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Sevoflurane 3.46939
GSM5746339 Mve, O2, 60mins brain region: the medial vestibular nucleus (MVe) treatment: O2 3.62592
GSM5746340 LHb, Propofol, 60mins brain region: the lateral habenula (LHb) treatment: Propofol 3.42089
GSM5746341 LHb, Intralipos, 60mins brain region: the lateral habenula (LHb) treatment: Intralipos 3.20422
GSM5746342 MHb, Propofol, 60mins brain region: the medial habenula (MHb) treatment: Propofol 3.4559
GSM5746343 MHb, Intralipos, 60mins brain region: the medial habenula (MHb) treatment: Intralipos 3.34731
GSM5746344 Sol, Propofol, 60mins brain region: the solitary nucleus (Sol) treatment: Propofol 3.51769
GSM5746345 Sol, Intralipos, 60mins brain region: the solitary nucleus (Sol) treatment: Intralipos 3.42934
GSM5746346 MVe, Propofol, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Propofol 3.3659
GSM5746347 MVe, Intralipos, 60mins brain region: the medial vestibular nucleus (MVe) treatment: Intralipos 3.37856

ID GSE53897
Title Genome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1303240 DRG RVM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.322175
GSM1303241 DRG RVM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.56546
GSM1303242 DRG RVM3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.589709
GSM1303243 DRG RVM7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.425472
GSM1303244 DRG RVOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.481119
GSM1303245 DRG RVOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.474934
GSM1303246 DRG RVOx5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.559627
GSM1303247 DRG RVOx7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.544362
GSM1303248 DRG RVS4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.394146
GSM1303249 DRG RVS5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.434376
GSM1303250 DRG RVS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.555839
GSM1303251 DRG RVS7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.517143
GSM1303252 DRG RSM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.431668
GSM1303253 DRG RSM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.56246
GSM1303254 DRG RSM4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.33029
GSM1303255 DRG RSM5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.432185
GSM1303256 DRG RSOx1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.304866
GSM1303257 DRG RSOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.499154
GSM1303258 DRG RSOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.455821
GSM1303259 DRG RSOx4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.474105
GSM1303260 DRG RSS1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.531583
GSM1303261 DRG RSS2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.344452
GSM1303262 DRG RSS3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.477598
GSM1303263 DRG RSS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.385667

ID GSE55573
Title Using DNA microarray to screen intracellular signal pathways of hypoglycemic activity by electroacupuncture of Zusanli (ST36) acupoints in streptozotocin-induced rats with diabetes
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1339443 Mock skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 117.8735
GSM1339444 EA (electroacupuncture) skeletal muscle strain: Wistar age: 8-10 week-old gender: Male 121.471