Gene symbol: Angptl8

Also known as: Rifl; Gm6484; EG624219

Organism: Mus musculus

Summary: Predicted to enable hormone activity. Involved in several processes, including regulation of lipid metabolic process; regulation of lipoprotein metabolic process; and triglyceride homeostasis. Acts upstream of or within cell maturation and fat cell differentiation. Predicted to be active in extracellular region. Orthologous to human ANGPTL8 (angiopoietin like 8). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 624219 Ensembl:ENSMUSG00000047822 AllianceGenome:MGI:3643534


GO Annotation


Category Term ID Term description
Process GO:0006629 Lipid metabolic process
Process GO:0007154 Cell communication
Process GO:0007165 Signal transduction
Process GO:0008152 Metabolic process
Process GO:0009893 Positive regulation of metabolic process
Process GO:0009987 Cellular process
Process GO:0010468 Regulation of gene expression
Process GO:0010604 Positive regulation of macromolecule metabolic process
Process GO:0010628 Positive regulation of gene expression
Process GO:0010954 Positive regulation of protein processing
Process GO:0019216 Regulation of lipid metabolic process
Process GO:0019222 Regulation of metabolic process
Process GO:0021700 Developmental maturation
Process GO:0023052 Signaling
Process GO:0030154 Cell differentiation
Process GO:0030162 Regulation of proteolysis
Process GO:0031323 Regulation of cellular metabolic process
Process GO:0032502 Developmental process
Process GO:0042592 Homeostatic process
Process GO:0043086 Negative regulation of catalytic activity
Process GO:0044092 Negative regulation of molecular function
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044255 Cellular lipid metabolic process
Process GO:0045444 Fat cell differentiation
Process GO:0045862 Positive regulation of proteolysis
Process GO:0048468 Cell development
Process GO:0048469 Cell maturation
Process GO:0048518 Positive regulation of biological process
Process GO:0048856 Anatomical structure development
Process GO:0048869 Cellular developmental process
Process GO:0048878 Chemical homeostasis
Process GO:0050746 Regulation of lipoprotein metabolic process
Process GO:0050789 Regulation of biological process
Process GO:0050790 Regulation of catalytic activity
Process GO:0050794 Regulation of cellular process
Process GO:0050896 Response to stimulus
Process GO:0051004 Regulation of lipoprotein lipase activity
Process GO:0051005 Negative regulation of lipoprotein lipase activity
Process GO:0051171 Regulation of nitrogen compound metabolic process
Process GO:0051173 Positive regulation of nitrogen compound metabolic process
Process GO:0051246 Regulation of protein metabolic process
Process GO:0051247 Positive regulation of protein metabolic process
Process GO:0051336 Regulation of hydrolase activity
Process GO:0051346 Negative regulation of hydrolase activity
Process GO:0051716 Cellular response to stimulus
Process GO:0055088 Lipid homeostasis
Process GO:0055090 Acylglycerol homeostasis
Process GO:0060191 Regulation of lipase activity
Process GO:0060192 Negative regulation of lipase activity
Process GO:0060255 Regulation of macromolecule metabolic process
Process GO:0065007 Biological regulation
Process GO:0065008 Regulation of biological quality
Process GO:0065009 Regulation of molecular function
Process GO:0070328 Triglyceride homeostasis
Process GO:0070613 Regulation of protein processing
Process GO:0071695 Anatomical structure maturation
Process GO:0071704 Organic substance metabolic process
Process GO:0080090 Regulation of primary metabolic process
Process GO:1903317 Regulation of protein maturation
Process GO:1903319 Positive regulation of protein maturation
Component GO:0005576 Extracellular region
Component GO:0110165 Cellular anatomical entity
Function GO:0005102 Signaling receptor binding
Function GO:0005179 Hormone activity
Function GO:0005488 Binding
Function GO:0005515 Protein binding
Function GO:0030545 Signaling receptor regulator activity
Function GO:0030546 Signaling receptor activator activity
Function GO:0048018 Receptor ligand activity
Function GO:0098772 Molecular function regulator activity

Pathway annotation


Category Term ID Term description
RCTM MMU-174824 Plasma lipoprotein assembly, remodeling, and clearance
RCTM MMU-382551 Transport of small molecules
RCTM MMU-8963889 Assembly of active LPL and LIPC lipase complexes
RCTM MMU-8963899 Plasma lipoprotein remodeling
KEGG mmu04979 Cholesterol metabolism

Expression profile of Angptl8 in omics data



ID GSE109165
Title Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway
Organism Mus musculus
GSM Sample info Characteristics Value
GSM2934457 WT_Naive_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 25.0
GSM2934458 WT_Naive_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 53.0
GSM2934459 WT_Naive_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 71.0
GSM2934460 WT_Naive_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: naïve 36.0
GSM2934461 KO_Naive_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 60.0
GSM2934462 KO_Naive_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 52.0
GSM2934463 KO_Naive_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 25.0
GSM2934464 KO_Naive_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: naïve 44.0
GSM2934465 WT_Morphine_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 30.0
GSM2934466 WT_Morphine_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 26.0
GSM2934467 WT_Morphine_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 72.0
GSM2934468 WT_Morphine_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: wildtype treatment: morphine 30.0
GSM2934469 KO_Morphine_1 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 32.0
GSM2934470 KO_Morphine_2 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 23.0
GSM2934471 KO_Morphine_3 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 14.0
GSM2934472 KO_Morphine_4 tissue: brain brain region: Periaqueductal gray region Sex: Male genotype: RGSz1 KO treatment: morphine 48.0

ID GSE205201
Title Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [mouse]
Organism Mus musculus
GSM Sample info Characteristics Value
GSM6208462 Mouse_Baseline_0h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 8.82491
GSM6208463 Mouse_Baseline_0h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 9.110324
GSM6208464 Mouse_Baseline_0h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 8.785923
GSM6208465 Mouse_Baseline_0h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 8.773776
GSM6208466 Mouse_Baseline_0h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Untreated hours after treatment: 0 8.876376
GSM6208467 Mouse_Vehicle_03h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 11.467117
GSM6208468 Mouse_Vehicle_03h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 11.767739
GSM6208469 Mouse_Vehicle_03h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 11.890827
GSM6208470 Mouse_Vehicle_03h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 11.835215
GSM6208471 Mouse_Vehicle_03h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 10.700607
GSM6208472 Mouse_Vehicle_06h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 11.565396
GSM6208473 Mouse_Vehicle_06h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 12.203166
GSM6208474 Mouse_Vehicle_06h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 9.30652
GSM6208475 Mouse_Vehicle_06h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 11.854845
GSM6208476 Mouse_Vehicle_06h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 11.167183
GSM6208477 Mouse_Vehicle_09h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 11.793583
GSM6208478 Mouse_Vehicle_09h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 11.895704
GSM6208479 Mouse_Vehicle_09h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 11.512185
GSM6208480 Mouse_Vehicle_09h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 10.818287
GSM6208481 Mouse_Vehicle_09h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 12.462568
GSM6208482 Mouse_Vehicle_24h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 10.992562
GSM6208483 Mouse_Vehicle_24h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 9.89067
GSM6208484 Mouse_Vehicle_24h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 9.540933
GSM6208485 Mouse_Vehicle_24h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 10.726744
GSM6208486 Mouse_Vehicle_24h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 12.203492
GSM6208487 Mouse_APAP_03h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 9.858638
GSM6208488 Mouse_APAP_03h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 11.298261
GSM6208489 Mouse_APAP_03h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 10.526203
GSM6208490 Mouse_APAP_03h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 10.506255
GSM6208491 Mouse_APAP_03h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 3 10.636904
GSM6208492 Mouse_APAP_06h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 10.73139
GSM6208493 Mouse_APAP_06h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 10.743199
GSM6208494 Mouse_APAP_06h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 11.215814
GSM6208495 Mouse_APAP_06h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 10.621399
GSM6208496 Mouse_APAP_06h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 6 9.079881
GSM6208497 Mouse_APAP_09h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 10.868337
GSM6208498 Mouse_APAP_09h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 11.539703
GSM6208499 Mouse_APAP_09h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 11.62756
GSM6208500 Mouse_APAP_09h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 10.88168
GSM6208501 Mouse_APAP_09h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 9 10.912539
GSM6208502 Mouse_APAP_24h_1 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 11.425129
GSM6208503 Mouse_APAP_24h_2 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 11.272624
GSM6208504 Mouse_APAP_24h_3 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 10.555348
GSM6208505 Mouse_APAP_24h_4 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 11.960985
GSM6208506 Mouse_APAP_24h_5 tissue: liver strain: C57Bl/6J Sex: male treatment: 300 mg/kg acetamnophen (o.g.) hours after treatment: 24 10.971051

ID GSE223541
Title Oxycodone withdrawal induces HDAC1/2-dependent transcriptional maladaptations in the reward pathway in a murine model of peripheral nerve injury
Organism Mus musculus
GSM Sample info Characteristics Value
GSM6958536 B1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sa 0.0
GSM6958537 C1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958538 F1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958539 H1 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958540 B2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958541 C2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958542 F2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958543 H2 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958544 B3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958545 C3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958546 F3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958547 H3 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0
GSM6958548 B4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: Sal 0.0
GSM6958549 C4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: Sham condition: oxy 0.0
GSM6958550 F4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: Sal 0.0
GSM6958551 H4 tissue: Brain strain: C57BL/6 Sex: male cell type: Nac genotype: SNI condition: oxy 0.0

ID GSE26364
Title Gene expression changes in alpha GABA receptors in the mice brains after prolonged ketamine administration
Organism Mus musculus
GSM Sample info Characteristics Value
GSM647254 Saline PFC 1 strain: ICR tissue: prefrontal cortex Sex: female 5.25025
GSM647255 Saline PFC 2 strain: ICR tissue: prefrontal cortex Sex: female 5.47197
GSM647256 Ketamine PFC 1 strain: ICR tissue: prefrontal cortex Sex: female 5.47416
GSM647257 Ketamine PFC 2 strain: ICR tissue: prefrontal cortex Sex: female 5.41898