Gene symbol: Plpp1

Also known as: Ppap2a

Organism: Rattus norvegicus

Summary: Enables diacylglycerol diphosphate phosphatase activity; lipid phosphatase activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation; phospholipid metabolic process; and sphingolipid metabolic process. Is integral component of plasma membrane. Orthologous to human PLPP1 (phospholipid phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

NCBI gene ID: 64369 Ensembl:ENSRNOG00000009980 AllianceGenome:RGD:621832


GO Annotation


Category Term ID Term description
Process GO:0006066 Alcohol metabolic process
Process GO:0006629 Lipid metabolic process
Process GO:0006643 Membrane lipid metabolic process
Process GO:0006644 Phospholipid metabolic process
Process GO:0006665 Sphingolipid metabolic process
Process GO:0006670 Sphingosine metabolic process
Process GO:0006672 Ceramide metabolic process
Process GO:0006793 Phosphorus metabolic process
Process GO:0006796 Phosphate-containing compound metabolic process
Process GO:0006807 Nitrogen compound metabolic process
Process GO:0007154 Cell communication
Process GO:0007165 Signal transduction
Process GO:0008152 Metabolic process
Process GO:0009987 Cellular process
Process GO:0016311 Dephosphorylation
Process GO:0019637 Organophosphate metabolic process
Process GO:0019751 Polyol metabolic process
Process GO:0023052 Signaling
Process GO:0030258 Lipid modification
Process GO:0034311 Diol metabolic process
Process GO:0034641 Cellular nitrogen compound metabolic process
Process GO:0043603 Cellular amide metabolic process
Process GO:0044237 Cellular metabolic process
Process GO:0044238 Primary metabolic process
Process GO:0044255 Cellular lipid metabolic process
Process GO:0044281 Small molecule metabolic process
Process GO:0046519 Sphingoid metabolic process
Process GO:0046839 Phospholipid dephosphorylation
Process GO:0050789 Regulation of biological process
Process GO:0050794 Regulation of cellular process
Process GO:0050896 Response to stimulus
Process GO:0051716 Cellular response to stimulus
Process GO:0065007 Biological regulation
Process GO:0071704 Organic substance metabolic process
Process GO:1901564 Organonitrogen compound metabolic process
Process GO:1901615 Organic hydroxy compound metabolic process
Component GO:0005886 Plasma membrane
Component GO:0005887 Integral component of plasma membrane
Component GO:0005901 Caveola
Component GO:0016020 Membrane
Component GO:0016021 Integral component of membrane
Component GO:0016324 Apical plasma membrane
Component GO:0031224 Intrinsic component of membrane
Component GO:0031226 Intrinsic component of plasma membrane
Component GO:0044853 Plasma membrane raft
Component GO:0045121 Membrane raft
Component GO:0045177 Apical part of cell
Component GO:0071944 Cell periphery
Component GO:0098590 Plasma membrane region
Component GO:0098857 Membrane microdomain
Component GO:0110165 Cellular anatomical entity
Function GO:0000810 Diacylglycerol diphosphate phosphatase activity
Function GO:0003824 Catalytic activity
Function GO:0008195 Phosphatidate phosphatase activity
Function GO:0016462 Pyrophosphatase activity
Function GO:0016787 Hydrolase activity
Function GO:0016788 Hydrolase activity, acting on ester bonds
Function GO:0016791 Phosphatase activity
Function GO:0016817 Hydrolase activity, acting on acid anhydrides
Function GO:0016818 Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Function GO:0042392 sphingosine-1-phosphate phosphatase activity
Function GO:0042577 Lipid phosphatase activity
Function GO:0042578 Phosphoric ester hydrolase activity
Function GO:0106235 ceramide-1-phosphate phosphatase activity

Pathway annotation


Category Term ID Term description
RCTM RNO-1430728 Metabolism
RCTM RNO-1660661 Sphingolipid de novo biosynthesis
RCTM RNO-428157 Sphingolipid metabolism
RCTM RNO-556833 Metabolism of lipids
KEGG rno00561 Glycerolipid metabolism
KEGG rno00564 Glycerophospholipid metabolism
KEGG rno00565 Ether lipid metabolism
KEGG rno00600 Sphingolipid metabolism
KEGG rno01100 Metabolic pathways
KEGG rno04072 Phospholipase D signaling pathway
KEGG rno04666 Fc gamma R-mediated phagocytosis
KEGG rno04975 Fat digestion and absorption
KEGG rno05231 Choline metabolism in cancer

Expression profile of Plpp1 in omics data



ID GSE136833
Title Effects of lidocaine on the expression of rat spinal cord
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4058984 Control_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.41105273
GSM4058985 Control_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.488460156
GSM4058986 Control_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.448175531
GSM4058987 Lidocaine_1 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.655119379
GSM4058988 Lidocaine_2 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.597618728
GSM4058989 Lidocaine_3 strain: Sprague-Dawley tissue: Lumbar segment of spinal cord 6.747620382

ID GSE139220
Title Expression data from sevoflurane anesthesia treated rat
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4134285 Brain_Control_rep1 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 7.503362
GSM4134286 Brain_Control_rep2 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 7.321785
GSM4134287 Brain_Control_rep3 strain: Sprague-Dawley age: 18-month old treatment: control tissue: hippocampus 7.269161
GSM4134288 Brain_Sevoflurane_rep1 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 7.098554
GSM4134289 Brain_Sevoflurane_rep2 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 7.463507
GSM4134290 Brain_Sevoflurane_rep3 strain: Sprague-Dawley age: 18-month old treatment: sevoflurane anesthesia tissue: hippocampus 7.411529

ID GSE143895
Title GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM4276356 dhsc01 strain: Sprague Dawley tissue: DHSC treatment: CCI 50.612
GSM4276357 dhsc03 strain: Sprague Dawley tissue: DHSC treatment: CCI 44.264
GSM4276358 dhsc05 strain: Sprague Dawley tissue: DHSC treatment: CCI 47.306
GSM4276359 dhsc13 strain: Sprague Dawley tissue: DHSC treatment: SHAM 51.743
GSM4276360 dhsc15 strain: Sprague Dawley tissue: DHSC treatment: SHAM 46.791

ID GSE205202
Title Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM6208507 Rat_Baseline_0h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 10.100304
GSM6208508 Rat_Baseline_0h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 9.854107
GSM6208509 Rat_Baseline_0h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 9.939304
GSM6208510 Rat_Baseline_0h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 10.155165
GSM6208511 Rat_Baseline_0h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Untreated hours after treatment: 0 10.042164
GSM6208512 Rat_Vehicle_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 9.636549
GSM6208513 Rat_Vehicle_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 9.687911
GSM6208514 Rat_Vehicle_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 9.652444
GSM6208515 Rat_Vehicle_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 9.604873
GSM6208516 Rat_Vehicle_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 3 9.621975
GSM6208517 Rat_Vehicle_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 9.692146
GSM6208518 Rat_Vehicle_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 9.651241
GSM6208519 Rat_Vehicle_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 9.461123
GSM6208520 Rat_Vehicle_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 9.537603
GSM6208521 Rat_Vehicle_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 6 9.712595
GSM6208522 Rat_Vehicle_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 9.59682
GSM6208523 Rat_Vehicle_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 9.544808
GSM6208524 Rat_Vehicle_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 9.58804
GSM6208525 Rat_Vehicle_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 9.631477
GSM6208526 Rat_Vehicle_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 9 9.547748
GSM6208527 Rat_Vehicle_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 9.608758
GSM6208528 Rat_Vehicle_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 9.613721
GSM6208529 Rat_Vehicle_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 9.647488
GSM6208530 Rat_Vehicle_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 9.575897
GSM6208531 Rat_Vehicle_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: Vehicle (1% [w/v] hydroxyethylcellulose, o.g.) hours after treatment: 24 9.85833
GSM6208532 Rat_APAP_03h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 9.909493
GSM6208533 Rat_APAP_03h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 9.76609
GSM6208534 Rat_APAP_03h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 9.749259
GSM6208535 Rat_APAP_03h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 9.696626
GSM6208536 Rat_APAP_03h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 3 9.607738
GSM6208537 Rat_APAP_06h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 9.367567
GSM6208538 Rat_APAP_06h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 9.427692
GSM6208539 Rat_APAP_06h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 9.50803
GSM6208540 Rat_APAP_06h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 9.494608
GSM6208541 Rat_APAP_06h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 6 9.571867
GSM6208542 Rat_APAP_09h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 9.201536
GSM6208543 Rat_APAP_09h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 9.402257
GSM6208544 Rat_APAP_09h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 9.433724
GSM6208545 Rat_APAP_09h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 9.49767
GSM6208546 Rat_APAP_09h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 9 9.347502
GSM6208547 Rat_APAP_24h_1 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 9.682754
GSM6208548 Rat_APAP_24h_2 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 9.638346
GSM6208549 Rat_APAP_24h_3 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 9.379505
GSM6208550 Rat_APAP_24h_4 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 9.81545
GSM6208551 Rat_APAP_24h_5 tissue: liver strain: Sprague-Dawley Sex: male treatment: 1000 mg/kg acetamnophen (o.g.) hours after treatment: 24 9.763686

ID GSE244436
Title Similarity and dissimilarity in alteration of gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM7816143 Liver, Control for SevoAnes tissue: liver genotype: wild type treatment: Control for SevoAnes 23.941311
GSM7816144 Liver, Anesthetized with sevoflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with sevoflurane for 6 h 24.517387
GSM7816145 Liver, Control for DesAnes tissue: liver genotype: wild type treatment: Control for DesAnes 19.441814
GSM7816146 Liver, Anesthetized with desflurane for 6 h tissue: liver genotype: wild type treatment: Anesthetized with desflurane for 6 h 24.704933

ID GSE2982
Title Effect of inhaled anesthetic to cultured cortical neurons
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM61779 Cell Culture Exposure (control1) Cy3 label;Cy5; 0.0943
GSM61796 Cell Culture Exposure (control2) Cy3; Cy5 -0.0485
GSM61797 Cell Culture Exposure (control3) Cy3; Cy5 0.124
GSM61798 Cell Culture Exposure (1MAC Halo1) Cy3; Cy5 0.154
GSM61799 Cell Culture Exposure (1MAC Halo2) Cy3; Cy5 0.114
GSM61800 Cell Culture Exposure (1MAC Halo3) Cy3; Cy5 0.17
GSM61801 Cell Culture Exposure (3MAC Halo1) Cy3; Cy5 -0.0278
GSM61802 Cell Culture Exposure (3MAC Halo2) Cy3; Cy5 -0.0348
GSM61803 Cell Culture Exposure (3MAC Halo3) Cy3; Cy5 -0.0456
GSM61804 Cell Culture Exposure (3MAC ISO1) Cy3; Cy5 0.181
GSM61805 Cell Culture Exposure (3MAC ISO2) Cy3; Cy5 0.242
GSM61806 Cell Culture Exposure (3MAC ISO3) Cy3; Cy5 0.0814

ID GSE53897
Title Genome-wide analysis of dorsal root ganglion (DRG) gene expression after morphine or oxycodone treatment
Organism Rattus norvegicus
GSM Sample info Characteristics Value
GSM1303240 DRG RVM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.889692
GSM1303241 DRG RVM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.113232
GSM1303242 DRG RVM3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.0401
GSM1303243 DRG RVM7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.527426
GSM1303244 DRG RVOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.778577
GSM1303245 DRG RVOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.097
GSM1303246 DRG RVOx5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.129465
GSM1303247 DRG RVOx7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.952138
GSM1303248 DRG RVS4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.993846
GSM1303249 DRG RVS5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.676908
GSM1303250 DRG RVS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.12466
GSM1303251 DRG RVS7 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.931844
GSM1303252 DRG RSM1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.456612
GSM1303253 DRG RSM2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.916076
GSM1303254 DRG RSM4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.056123
GSM1303255 DRG RSM5 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.092548
GSM1303256 DRG RSOx1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.833389
GSM1303257 DRG RSOx2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.091275
GSM1303258 DRG RSOx3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.071464
GSM1303259 DRG RSOx4 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 5.968015
GSM1303260 DRG RSS1 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.854891
GSM1303261 DRG RSS2 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.015305
GSM1303262 DRG RSS3 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.139847
GSM1303263 DRG RSS6 strain: sprague-dawley age: 3 months tissue: dorsal root ganglion 6.191425