Overview of HBV associated Carcinoma, Hepatocellular (Mutation)

ID Literature Title Group
1 30505167 Hepatitis B virus precore G1896A mutation in chronic liver disease patients with HBeAg negative serology from North India
Mutation
2 10535488 Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen
Mutation
3 11002246 Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma
Mutation
4 14756274 Efficacy of combined lamivudine and adefovir dipivoxil treatment for severe HBV graft reinfection after living donor liver transplantation
Mutation
5 16080797 HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers
Mutation
6 17888035 Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma
Mutation
7 21461076 Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection
Mutation
8 21490166 Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection
Mutation
9 21933446 Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B
Mutation
10 22882650 Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients
Mutation
11 23383661 Synergistic effects of A1896, T1653 and T1762/A1764 mutations in genotype c2 hepatitis B virus on development of hepatocellular carcinoma
Mutation
12 32568442 The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population
Mutation
13 34899733 The Impact of HBV Quasispecies Features on Immune Status in HBsAg+/HBsAb+ Patients With HBV Genotype C Using Next-Generation Sequencing
Mutation
14 37735836 CHB patients with rtA181T-mutated HBV infection are associated with higher risk hepatocellular carcinoma due to increases in mutation rates of tumour suppressor genes
Mutation
15 16618410 High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases
Mutation
16 17203204 Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam
Mutation
17 18551606 Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection
Mutation
18 29285238 Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients
Mutation
19 31565220 Association between host TNF-alpha, TGF-beta1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients
Mutation
20 9824278 The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss
Mutation
21 9857356 Current aspects of hepatitis B surface antigen mutants in Singapore
Mutation
22 10949955 Detection of hepatitis B virus surface antigen mutants in paraffin-embedded hepatocellular carcinoma tissues
Mutation
23 11468748 Full-length genomic analysis of hepatitis B virus isolates in a patient progressing from hepatitis to hepatocellular carcinoma
Mutation
24 12805468 Coexistence of two distinct secretion mutations (P5T and I97L) in hepatitis B virus core produces a wild-type pattern of secretion
Mutation
25 15543574 Comparison of full length sequences of hepatitis B virus isolates in hepatocellular carcinoma patients and asymptomatic carriers of Korea
Mutation
26 16907843 Virological analysis, genotypes and mutational patterns of the HBV precore/core gene in HBV/HCV-related hepatocellular carcinoma
Mutation
27 17464459 A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan
Mutation
28 17652471 Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2
Mutation
29 18216102 Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus
Mutation
30 18695135 Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma
Mutation
31 18844615 HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study
Mutation
32 18939932 Combined mutations in pre-s/surface and core promoter/precore regions of hepatitis B virus increase the risk of hepatocellular carcinoma: a case-control study
Mutation
33 19043921 The oncogenic potential of hepatitis B virus rtA181T/ surface truncation mutant
Mutation
34 19187787 Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes
Mutation
35 20699378 Comparison study on the complete sequence of hepatitis B virus identifies new mutations in core gene associated with hepatocellular carcinoma
Mutation
36 20814897 Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma
Mutation
37 20820820 A population-based cohort study for the risk factors of HCC among hepatitis B virus mono-infected subjects in Japan
Mutation
38 20962085 Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections
Mutation
39 21063480 A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma
Mutation
40 21104161 Association of novel mutations and haplotypes in the preS region of hepatitis B virus with hepatocellular carcinoma
Mutation
41 21108338 A matched case-control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma
Mutation
42 21325784 Hepatitis B virus core protein variations differ in tumor and adjacent nontumor tissues from patients with hepatocellular carcinoma
Mutation
43 21865669 Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC
Mutation
44 21950207 Prevalence of hepatitis B genotype and viral basic core promoter and precore mutations among teenagers in Macao: relationship with hepatocellular carcinoma development
Mutation
45 22012717 Clonal analysis of hepatitis B viruses among blood donors from Joinville, Brazil: evidence of dual infections, intragenotype recombination and markers of risk for hepatocellular carcinoma
Mutation
46 22014121 Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients
Mutation
47 22136288 Mutational complex genotype of the hepatitis B virus X /precore regions as a novel predictive marker for hepatocellular carcinoma
Mutation
48 22178505 Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China
Mutation
49 22510145 Natural history of chronic hepatitis B: what exactly has REVEAL revealed?
Mutation
50 22675557 Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis
Mutation
51 22720023 Hepatitis B virus gene mutations in liver diseases: a report from New Delhi
Mutation
52 22962577 Re-evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis
Mutation
53 23071796 Naturally occurring precore/core region mutations of hepatitis B virus genotype C related to hepatocellular carcinoma
Mutation
54 23104706 Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma
Mutation
55 23166535 Effects of antiviral therapy on the recurrence of hepatocellular carcinoma after curative resection or liver transplantation
Mutation
56 23386590 Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B virus mutations in hepatocellular carcinoma
Mutation
57 23516510 Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk
Mutation
58 23621183 Hepatitis B virus gene C1653T polymorphism mutation and hepatocellular carcinoma risk: an updated meta-analysis
Mutation
59 24118778 Association of a potential functional pre-miR-218 polymorphism and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk
Mutation
60 24344773 Combinations of eight key mutations in the X/preC region and genomic activity of hepatitis B virus are associated with hepatocellular carcinoma
Mutation
61 24346287 HBx mutants differentially affect the activation of hypoxia-inducible factor-1alpha in hepatocellular carcinoma
Mutation
62 24583110 Generation of a human hepatoma cell line supporting efficient replication of a lamivudine resistant hepatitis B virus
Mutation
63 24748463 Association of miRNA-122-binding site polymorphism at the interleukin-1 alpha gene and its interaction with hepatitis B virus mutations with hepatocellular carcinoma risk
Mutation
64 24763132 Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers
Mutation
65 24788140 Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma
Mutation
66 24849936 Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in Qidong, China
Mutation
67 25019072 Hidden secret in hepatitis B viral X protein mutation and hypoxia-inducible factor-1alpha in hepatocarcinoma cancer
Mutation
68 25501679 Association between HBV Pre-S mutations and the intracellular HBV DNAs in HBsAg-positive hepatocellular carcinoma in China
Mutation
69 25942596 The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data
Mutation
70 26194746 Outcomes including liver histology after liver transplantation for chronic hepatitis B using oral antiviral therapy alone
Mutation
71 26543337 Quantitative evaluation of hepatitis B virus mutations and hepatocellular carcinoma risk: a meta-analysis of prospective studies
Mutation
72 26706415 A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines
Mutation
73 26715821 Development of Fok-I based nested polymerase chain reaction-restriction fragment length polymorphism analysis for detection of hepatitis B virus X region V5M mutation
Mutation
74 26848866 Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis
Mutation
75 27075395 Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma
Mutation
76 27303803 Hepatitis B Virus Core Promoter Double Mutations (A1762T, G1764A) Are Associated with Lower Levels of Serum Dihydrolipoyl Dehydrogenase
Mutation
77 27340355 Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma
Mutation
78 27420729 HBx mutations promote hepatoma cell migration through the Wnt/beta-catenin signaling pathway
Mutation
79 27422771 The relationship between HBcrAg and HBV reinfection in HBV related post-liver transplantation patients
Mutation
80 27486882 Occult HBV infection in HCC and cirrhotic tissue of HBsAg-negative patients: a virological and clinical study
Mutation
81 27727182 Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China
Mutation
82 27779207 HBV core promoter mutations and AKT upregulate S-phase kinase-associated protein 2 to promote postoperative hepatocellular carcinoma progression
Mutation
83 28339094 F221Y mutation in hepatitis B virus reverse transcriptase is associated with hepatocellular carcinoma prognosis following liver resection
Mutation
84 28373061 Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer
Mutation
85 29287068 Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients
Mutation
86 29609638 The truncated mutant HBsAg expression increases the tumorigenesis of hepatitis B virus by regulating TGF-beta/Smad signaling pathway
Mutation
87 29893492 An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People
Mutation
88 30472417 The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro
Mutation
89 31341412 Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations
Mutation
90 32504396 Molecular characterization of hepatitis B virus isolated from Black South African cancer patients, with and without hepatocellular carcinoma
Mutation
91 32722114 Next-Generation Sequencing-Based Quantitative Detection of Hepatitis B Virus Pre-S Mutants in Plasma Predicts Hepatocellular Carcinoma Recurrence
Mutation
92 33247709 Compartmentalized evolution of hepatitis B virus contributes differently to the prognosis of hepatocellular carcinoma
Mutation
93 33381105 Comprehensive Analysis of Clinically Significant Hepatitis B Virus Mutations in Relation to Genotype, Subgenotype and Geographic Region
Mutation
94 35390033 Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients
Mutation
95 35800619 CA10 is associated with HBV-related hepatocarcinogenesis
Mutation
96 36102940 Compartmentalisation of Hepatitis B virus X gene evolution in hepatocellular carcinoma microenvironment and the genotype-phenotype correlation of tumorigenicity in HBV-related patients with hepatocellular carcinoma
Mutation
97 36292082 Characteristics of Hepatitis B Virus Genotype and Sub-Genotype in Hepatocellular Cancer Patients in Vietnam
Mutation
98 37681020 Low host immune pressure may be associated with the development of hepatocellular carcinoma: a longitudinal analysis of complete genomes of the HBV 1762T, 1764A mutant
Mutation
99 37772469 The A1762T/G1764A mutations enhance HBV replication by alternating viral transcriptome
Mutation
100 38242020 The dynamic variation position and predominant quasispecies of hepatitis B virus: Novel predictors of early hepatocarcinoma
Mutation
101 39986372 A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults
Mutation
102 35415256 Precore/core mutations of hepatitis B virus genotype D arising in different states of infection
Mutation
103 20959817 Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma
Mutation
104 22919746 [Hepatitis B virus (HBV) mutation in enhancer I (HBV Enh I)/X-promoter and the relationship between chronic HBV-related disease spectrum]
Mutation
105 23272650 Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment
Mutation
106 24637457 Mutation profiling of the hepatitis B virus strains circulating in North Indian population
Mutation
107 30043328 Clinical implication and viral mutation in basal core promoter/pre-core of hepatitis B virus C/D recombinant
Mutation
108 31341154 Association Between HBx Variations and Development of Severe Liver Disease Among Indonesian Patients
Mutation
109 32523313 Conservation and variability of hepatitis B core at different chronic hepatitis stages
Mutation
110 33296295 Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection
Mutation
111 34029727 Increased hepatitis B virus quasispecies diversity is correlated with liver fibrosis progression
Mutation
112 35880842 The effects of the interactions of STAT4 rs7574865 with HBV mutations on the risk of hepatocellular carcinoma
Mutation
113 38037048 HLA-DR genetic polymorphisms and hepatitis B virus mutations affect the risk of hepatocellular carcinoma in Han Chinese population
Mutation
114 18508941 Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus
Mutation
115 20419326 Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma
Mutation
116 21323729 Natural history of chronic hepatitis B REVEALed
Mutation
117 21941645 Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia
Mutation
118 23304671 HBV Subgenotype C2 Infection, A1762T/G1764A Mutations May Contribute To Hepatocellular Carcinoma with Cirrhosis in Southeast China
Mutation
119 23903686 Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively
Mutation
120 25281206 Impacts of human leukocyte antigen DQ genetic polymorphisms and their interactions with hepatitis B virus mutations on the risks of viral persistence, liver cirrhosis, and hepatocellular carcinoma
Mutation
121 26290395 Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Carcinoma: A Clinic-Based Cohort Study
Mutation
122 26899956 Molecular characterization of hepatitis B virus from chronically-infected patients in Niamey, Niger
Mutation
123 28654219 A comparative study of hepatitis B virus X protein mutants K130M, V131I and KV130/131MI to investigate their roles in fibrosis, cirrhosis and hepatocellular carcinoma
Mutation
124 28902288 Basal core promoter and precore mutations among hepatitis B virus circulating in Brazil and its association with severe forms of hepatic diseases
Mutation
125 31105017 Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patients
Mutation
126 32155009 [The prevalence clinically significant virus mutations among patients with chronic viral hepatitis B.]
Mutation
127 33947693 The Landscape of Cell-Free HBV Integrations and Mutations in Cirrhosis and Hepatocellular Carcinoma Patients
Mutation
128 19431214 A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular carcinoma patients in Taiwan
Mutation
129 29434654 Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection
Mutation
130 23805180 Occult and Overt HBV Co-Infections Independently Predict Postoperative Prognosis in HCV-Associated Hepatocellular Carcinoma
Mutation
131 19574418 Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis
Mutation
132 19664630 Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression
Mutation
133 19998495 Clinical relevance and public health significance of hepatitis B virus genomic variations
Mutation
134 20160279 Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study
Mutation
135 24973814 Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related viral mutations in the post-immunization era
Mutation
136 30702819 Analyses of the Genetic Diversities and Mutations of the Hepatitis B Virus Genome BCP/Pre C Region
Mutation
137 34534105 Nucleotide variants in hepatitis B virus preS region predict the recurrence of hepatocellular carcinoma
Mutation
138 30406036 The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease
Mutation
139 31501793 Comparison of pre-S1/S2 variations of hepatitis B virus between asymptomatic carriers and cirrhotic/hepatocellular carcinoma-affected individuals
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.