Overview of HCMV associated Cell line (Mutation)

ID Literature Title Group
1 1653497 Human cytomegalovirus strain Towne pp28 gene: sequence comparison to pp28 of HCMV AD169 and stable expression in Chinese hamster ovary cells
Mutation
2 2159553 Sequence requirements for proteolytic processing of glycoprotein B of human cytomegalovirus strain Towne
Mutation
3 7559530 Single-chain recombinant human cytomegalovirus protease. Activity against its natural protein substrate and fluorogenic peptide substrates
Mutation
4 7738144 Value of a new rapid non-radioactive sequencing method for analysis of the cytomegalovirus UL97 gene in ganciclovir-resistant strains
Mutation
5 8207815 Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir
Mutation
6 8381637 A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives
Mutation
7 8892927 Mutations in the carboxyl-terminal hydrophobic sequence of human cytomegalovirus glycoprotein B alter transport and protein chaperone binding
Mutation
8 9260696 Humoral immune response to functional regions of human cytomegalovirus glycoprotein B
Mutation
9 9420278 Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product
Mutation
10 9558326 Site-directed mutagenesis probing the catalytic role of arginines 165 and 166 of human cytomegalovirus protease
Mutation
11 9573236 Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56
Mutation
12 9621055 Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments
Mutation
13 9658112 Steady-state plasma membrane expression of human cytomegalovirus gB is determined by the phosphorylation state of Ser900
Mutation
14 9721246 A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture
Mutation
15 9864050 Genetic analysis of a ganciclovir-resistant human cytomegalovirus mutant
Mutation
16 11602710 Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression
Mutation
17 11861863 Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication
Mutation
18 11861864 SUMO-1 modification of human cytomegalovirus IE1/IE72
Mutation
19 12163586 Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions
Mutation
20 12525621 Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agents
Mutation
21 12637079 Point mutations induced by foscarnet (PFA) in the human cytomegalovirus DNA polymerase
Mutation
22 12663783 Strain variations in single amino acids of the 86-kilodalton human cytomegalovirus major immediate-early protein (IE2) affect its functional and biochemical properties: implications of dynamic protein conformation
Mutation
23 14557635 Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27
Mutation
24 14694102 Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides
Mutation
25 15194788 Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavir
Mutation
26 15767408 Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein B
Mutation
27 15980340 Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene
Mutation
28 16207954 Use of time-saving flow cytometry for rapid determination of resistance of human cytomegalovirus to ganciclovir
Mutation
29 16304146 New reporter cell line to evaluate the sequential emergence of multiple human cytomegalovirus mutations during in vitro drug exposure
Mutation
30 16571804 Inhibition of cellular DNA synthesis by the human cytomegalovirus IE86 protein is necessary for efficient virus replication
Mutation
31 16897654 Characterization of human cytomegalovirus (HCMV) UL97 mutations found in a valganciclovir/oral ganciclovir prophylactic trial by use of a bacterial artificial chromosome containing the HCMV genome
Mutation
32 17079329 The amino-conserved domain of human cytomegalovirus UL80a proteins is required for key interactions during early stages of capsid formation and virus production
Mutation
33 17197042 Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet
Mutation
34 17376893 The autoregulatory and transactivating functions of the human cytomegalovirus IE86 protein use independent mechanisms for promoter binding
Mutation
35 17942550 Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant
Mutation
36 18385241 Multimerization of tegument protein pp28 within the assembly compartment is required for cytoplasmic envelopment of human cytomegalovirus
Mutation
37 18423509 Nuclear trafficking of the human cytomegalovirus pp71 (ppUL82) tegument protein
Mutation
38 18502683 Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus
Mutation
39 19369477 Biologic and immunologic effects of knockout of human cytomegalovirus pp65 nuclear localization signal
Mutation
40 19546362 Fluorescence-based assay for phenotypic characterization of human cytomegalovirus polymerase mutations regarding drug susceptibility and viral replicative fitness
Mutation
41 19570866 The flexible loop of the human cytomegalovirus DNA polymerase processivity factor ppUL44 is required for efficient DNA binding and replication in cells
Mutation
42 20385869 Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance
Mutation
43 20732421 Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia
Mutation
44 20843736 Contrasting effects on ganciclovir susceptibility and replicative capacity of two mutations at codon 466 of the human cytomegalovirus UL97 gene
Mutation
45 20876378 Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase
Mutation
46 21248036 Human cytomegalovirus UL97 kinase and nonkinase functions mediate viral cytoplasmic secondary envelopment
Mutation
47 21295516 Phenotypic diversity of cytomegalovirus DNA polymerase gene variants observed after antiviral therapy
Mutation
48 21429239 The effects of maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein
Mutation
49 21709106 Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet
Mutation
50 21788463 Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase
Mutation
51 21865379 Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32
Mutation
52 21900421 Structural modelling and mutagenesis of human cytomegalovirus alkaline nuclease UL98
Mutation
53 21968367 Cyclopropavir susceptibility of cytomegalovirus DNA polymerase mutants selected after antiviral drug exposure
Mutation
54 22552942 Human cytomegalovirus UL97 kinase alters the accumulation of CDK1
Mutation
55 22589554 Specific residues of a conserved domain in the N terminus of the human cytomegalovirus pUL50 protein determine its intranuclear interaction with pUL53
Mutation
56 23650158 Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus
Mutation
57 23650173 Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance
Mutation
58 24501413 Highly acidic C-terminal region of cytomegalovirus pUL96 determines its functions during virus maturation independently of a direct pp150 interaction
Mutation
59 25348532 Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89
Mutation
60 26259791 Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance
Mutation
61 26559840 Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses
Mutation
62 27044553 Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance
Mutation
63 27940027 Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene
Mutation
64 28446569 Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene
Mutation
65 28807919 Drug Susceptibility and Replicative Capacity of Multidrug-Resistant Recombinant Human Cytomegalovirus Harboring Mutations in UL56 and UL54 Genes
Mutation
66 28827420 Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds
Mutation
67 28878758 Differences in Growth Properties among Two Human Cytomegalovirus Glycoprotein O Genotypes
Mutation
68 29107686 A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance
Mutation
69 29649495 A Guinea pig cytomegalovirus resistant to the DNA maturation inhibitor BDCRB
Mutation
70 29914965 New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir
Mutation
71 30258013 Expression of Human Cytomegalovirus IE1 Leads to Accumulation of Mono-SUMOylated PML That Is Protected from Degradation by Herpes Simplex Virus 1 ICP0
Mutation
72 31427511 Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability
Mutation
73 31431555 Human Cytomegalovirus US28 Ligand Binding Activity Is Required for Latency in CD34(+) Hematopoietic Progenitor Cells and Humanized NSG Mice
Mutation
74 31941787 Evasion of a Human Cytomegalovirus Entry Inhibitor with Potent Cysteine Reactivity Is Concomitant with the Utilization of a Heparan Sulfate Proteoglycan-Independent Route of Entry
Mutation
75 32015044 Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase
Mutation
76 32321808 The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50
Mutation
77 32690704 Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor
Mutation
78 33588012 Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases
Mutation
79 33875432 Impact of Amino Acid Substitutions in Region II and Helix K of Herpes Simplex Virus 1 and Human Cytomegalovirus DNA Polymerases on Resistance to Foscarnet
Mutation
80 34082757 Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells
Mutation
81 34201364 Selection of Human Cytomegalovirus Mutants with Resistance against PDGFRalpha-Derived Entry Inhibitors
Mutation
82 34550009 Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV)
Mutation
83 34560144 Opposite effects of cytomegalovirus UL54 exonuclease domain mutations on acyclovir and cidofovir susceptibility
Mutation
84 35185843 Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance
Mutation
85 35746751 Design of a US28 ORF Deletion Virus in a Temperature-Sensitive Cytomegalovirus Strain Fails to Promote Lytic Replication in Hematopoietic Cells
Mutation
86 37113003 The RL13 Temperance Factor Represses Replication of the Highly Cell Culture-Adapted Towne Strain of Human Cytomegalovirus
Mutation
87 37976321 A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex
Mutation
88 38163624 Ganciclovir and maribavir cross-resistance revisited: Relative drug susceptibilities of canonical cytomegalovirus mutants
Mutation
89 39315800 Growth defect of domain III glycoprotein B mutants of human cytomegalovirus reverted by compensatory mutations co-localizing in post-fusion conformation
Mutation
90 39655954 Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation
Mutation
91 38805802 Structure-guided mutagenesis targeting interactions between pp150 tegument protein and small capsid protein identify five lethal and two live-attenuated HCMV mutants
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.