Overview of HSV1 associated Cell line (Mutation)

ID Literature Title Group
1 12829822 Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids
Mutation
2 14694096 A point mutation within conserved region VI of herpes simplex virus type 1 DNA polymerase confers altered drug sensitivity and enhances replication fidelity
Mutation
3 29186456 The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase
Mutation
4 39717706 Combined use of pritelivir with acyclovir or foscarnet suppresses evolution of HSV-1 drug resistance
Mutation
5 24352467 Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery
Mutation
6 11264356 AlaArg motif in the carboxyl terminus of the gamma(1)34.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates eIF-2alpha
Mutation
7 30327436 Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant
Mutation
8 22695228 Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L (gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor alpha
Mutation
9 20686018 A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor alpha (PILRalpha) abrogates PILRalpha-dependent viral entry and reduces pathogenesis
Mutation
10 10766304 Herpes simplex virus 1 (HSV-1) strain HSZP glycoprotein B gene: comparison of mutations among strains differing in virulence
Mutation
11 12727347 A single amino acid substitution in the cytoplasmic tail of the glycoprotein B of herpes simplex virus 1 affects both syncytium formation and binding to intracellular heparan sulfate
Mutation
12 17604805 Molecular basis for resistance of herpes simplex virus type 1 mutants to the sulfated oligosaccharide inhibitor PI-88
Mutation
13 19846518 Effects of phosphorylation of herpes simplex virus 1 envelope glycoprotein B by Us3 kinase in vivo and in vitro
Mutation
14 23152509 Novel mutations in gB and gH circumvent the requirement for known gD Receptors in herpes simplex virus 1 entry and cell-to-cell spread
Mutation
15 37919266 Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection
Mutation
16 15078954 The herpes simplex virus JMP mutant enters receptor-negative J cells through a novel pathway independent of the known receptors nectin1, HveA, and nectin2
Mutation
17 2467994 Fine mapping of antigenic site II of herpes simplex virus glycoprotein D
Mutation
18 8116256 Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity
Mutation
19 15613355 Potential nectin-1 binding site on herpes simplex virus glycoprotein d
Mutation
20 2173780 Glycoprotein D of herpes simplex virus encodes a domain which precludes penetration of cells expressing the glycoprotein by superinfecting herpes simplex virus
Mutation
21 8202498 Mapping of herpes simplex virus 1 genes with mutations which overcome host restrictions to infection
Mutation
22 18243431 An HSV-1 gD mutant virus as an entry-impaired live virus vaccine
Mutation
23 15890943 A heptad repeat in herpes simplex virus 1 gH, located downstream of the alpha-helix with attributes of a fusion peptide, is critical for virus entry and fusion
Mutation
24 18222518 Mutagenic analysis of herpes simplex virus type 1 glycoprotein L reveals the importance of an arginine-rich region for function
Mutation
25 10482598 Genetic analysis of the role of herpes simplex virus type 1 glycoprotein K in infectious virus production and egress
Mutation
26 1656625 Further characterization of ts1-8, a mutant of herpes simplex virus type 1
Mutation
27 19369321 Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops
Mutation
28 10627537 Nectin2alpha (PRR2alpha or HveB) and nectin2delta are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D
Mutation
29 2154881 Antigenic and functional analysis of a neutralization site of HSV-1 glycoprotein D
Mutation
30 2463380 Identification of mar mutations in herpes simplex virus type 1 glycoprotein B which alter antigenic structure and function in virus penetration
Mutation
31 25673718 Contrasting effects of W781V and W780V mutations in helix N of herpes simplex virus 1 and human cytomegalovirus DNA polymerases on antiviral drug susceptibility
Mutation
32 23221554 N-terminal phosphorylation sites of herpes simplex virus 1 ICP0 differentially regulate its activities and enhance viral replication
Mutation
33 1846199 A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties
Mutation
34 29950407 Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease
Mutation
35 30598436 Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication
Mutation
36 39772124 A Mutation in the Herpes Simplex Virus Type 1 (HSV-1) UL29 Gene is Associated with Anti-Herpesvirus Drugs' Susceptibility
Mutation
37 17634223 Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice
Mutation
38 8551616 Resistance of herpes simplex virus type 1 to peptidomimetic ribonucleotide reductase inhibitors: selection and characterization of mutant isolates
Mutation
39 19259663 PET imaging of HSV1-tk mutants with acquired specificity toward pyrimidine- and acycloguanosine-based radiotracers
Mutation
40 19223410 Molecular-genetic PET imaging using an HSV1-tk mutant reporter gene with enhanced specificity to acycloguanosine nucleoside analogs
Mutation
41 33631413 Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication
Mutation
42 27426251 Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility
Mutation
43 29848849 Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported
Mutation
44 38619252 Combination of ganciclovir and trifluridine prevents drug-resistance emergence in HSV-1
Mutation
45 28956767 The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus
Mutation
46 21791071 Herpes simplex virus type 1 UL14 tegument protein regulates intracellular compartmentalization of major tegument protein VP16
Mutation
47 10482584 Proteolytic cleavage of the amino terminus of the U(L)15 gene product of herpes simplex virus type 1 is coupled with maturation of viral DNA into unit-length genomes
Mutation
48 37959793 Large Subunit of the Human Herpes Simplex Virus Terminase as a Promising Target in Design of Anti-Herpesvirus Agents
Mutation
49 24760889 Phenylalanine residues at the carboxyl terminus of the herpes simplex virus 1 UL20 membrane protein regulate cytoplasmic virion envelopment and infectious virus production
Mutation
50 19864385 Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin
Mutation
51 39696608 Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance
Mutation
52 31332074 Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1
Mutation
53 21561917 Herpes simplex virus 1 pUL34 plays a critical role in cell-to-cell spread of virus in addition to its role in virus replication
Mutation
54 37787529 Extragenic suppression of an HSV-1 UL34 nuclear egress mutant reveals role for pUS9 as an inhibitor of epithelial cell-to-cell spread
Mutation
55 34133898 Herpes Simplex Virus 1 UL34 Mutants That Affect Membrane Budding Regulation and Nuclear Lamina Disruption
Mutation
56 22112849 Identification of a single amino acid residue which is critical for the interaction between HSV-1 inner tegument proteins pUL36 and pUL37
Mutation
57 8970998 Expression and function of the equine herpesvirus 1 virion-associated host shutoff homolog
Mutation
58 23636254 Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-alpha-induced NF-kappaB activation by interacting with p65/RelA and p50/NF-kappaB1
Mutation
59 21734045 Herpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells
Mutation
60 22013045 Analysis of the interaction between the essential herpes simplex virus 1 tegument proteins VP16 and VP1/2
Mutation
61 34228537 Characteristics of Helicase-Primase Inhibitor Amenamevir-Resistant Herpes Simplex Virus
Mutation
62 22687623 Characterization of virus strains resistant to the herpes virus helicase-primase inhibitor ASP2151 (Amenamevir)
Mutation
63 19740984 Tryptophan residues in the portal protein of herpes simplex virus 1 critical to the interaction with scaffold proteins and incorporation of the portal into capsids
Mutation
64 17634220 In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3
Mutation
65 19297494 Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis
Mutation
66 34935440 The US3 Kinase of Herpes Simplex Virus Phosphorylates the RNA Sensor RIG-I To Suppress Innate Immunity
Mutation
67 27030266 Roles of Us8A and Its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis
Mutation
68 21715485 Autocatalytic activity of the ubiquitin-specific protease domain of herpes simplex virus 1 VP1-2
Mutation
69 35632611 Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication
Mutation
70 9507079 Understanding the molecular mechanism of viral resistance to peptidomimetic inhibitors of ribonucleotide reductase
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.