Overview of IV associated Cell line (Mutation)

ID Literature Title Group
1 19641000 Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
Mutation
2 32887429 In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients
Mutation
3 20409386 Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus
Mutation
4 1566586 A single point mutation of the influenza C virus glycoprotein (HEF) changes the viral receptor-binding activity
Mutation
5 11991966 In vitro selection and characterization of influenza A (A/N9) virus variants resistant to a novel neuraminidase inhibitor, A-315675
Mutation
6 31400550 The evolution and characterization of influenza A(H7N9) virus under the selective pressure of peramivir
Mutation
7 32832869 Investigation of the Drug Resistance Mechanism of M2-S31N Channel Blockers through Biomolecular Simulations and Viral Passage Experiments
Mutation
8 16227287 Influenza virus hemagglutinin (H3 subtype) requires palmitoylation of its cytoplasmic tail for assembly: M1 proteins of two subtypes differ in their ability to support assembly
Mutation
9 33985852 Changes in sialic acid binding associated with egg adaptation decrease live attenuated influenza virus replication in human nasal epithelial cell cultures
Mutation
10 27226365 A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8+ T Cell Responses
Mutation
11 35583364 Mutation L319Q in the PB1 Polymerase Subunit Improves Attenuation of a Candidate Live-Attenuated Influenza A Virus Vaccine
Mutation
12 24173220 A novel cytotoxic sequence contributes to influenza A viral protein PB1-F2 pathogenicity and predisposition to secondary bacterial infection
Mutation
13 27440882 Reversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic Virus
Mutation
14 28053101 Generation of a Genetically Stable High-Fidelity Influenza Vaccine Strain
Mutation
15 33099886 Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil
Mutation
16 21930946 E339...R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors
Mutation
17 25817403 A single NS2 mutation of K86R promotes PR8 vaccine donor virus growth in Vero cells
Mutation
18 27405392 G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology
Mutation
19 12435681 Mechanism by which mutations at his274 alter sensitivity of influenza a virus n1 neuraminidase to oseltamivir carboxylate and zanamivir
Mutation
20 35045267 Identification of a Permissive Secondary Mutation That Restores the Enzymatic Activity of Oseltamivir Resistance Mutation H275Y
Mutation
21 29518414 Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers
Mutation
22 30328013 CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus
Mutation
23 29097654 Role of influenza A virus NP acetylation on viral growth and replication
Mutation
24 29046451 Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail
Mutation
25 39676676 Mutagenesis studies suggest a mechanism for influenza polymerase stalling during polyadenylation
Mutation
26 9144179 The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer
Mutation
27 12438632 Restriction of viral replication by mutation of the influenza virus matrix protein
Mutation
28 3753607 Studies on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus
Mutation
29 9060710 Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection
Mutation
30 20573832 Tyrosines in the influenza A virus M2 protein cytoplasmic tail are critical for production of infectious virus particles
Mutation
31 19436701 Avian Influenza virus glycoproteins restrict virus replication and spread through human airway epithelium at temperatures of the proximal airways
Mutation
32 22090209 Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells
Mutation
33 1700825 Mechanism of antigenic variation in an individual epitope on influenza virus N9 neuraminidase
Mutation
34 12834856 A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding
Mutation
35 23077315 The compensatory G88R change is essential in restoring the normal functions of influenza A/WSN/33 virus matrix protein 1 with a disrupted nuclear localization signal
Mutation
36 17922571 A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence
Mutation
37 21734052 Amino acid residues 253 and 591 of the PB2 protein of avian influenza virus A H9N2 contribute to mammalian pathogenesis
Mutation
38 22808250 Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence
Mutation
39 22615752 Functional analysis of conserved motifs in influenza virus PB1 protein
Mutation
40 23626667 Quantitative characterization of glycan-receptor binding of H9N2 influenza A virus hemagglutinin
Mutation
41 25078692 A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence
Mutation
42 25505067 The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA
Mutation
43 23860768 Resistance to neuraminidase inhibitors conferred by an R292K mutation in a human influenza virus H7N9 isolate can be masked by a mixed R/K viral population
Mutation
44 26738596 Species difference in ANP32A underlies influenza A virus polymerase host restriction
Mutation
45 19119420 Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N
Mutation
46 21852950 Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species
Mutation
47 25231317 Amino acid changes in the influenza A virus PA protein that attenuate avian H5N1 viruses in mammals
Mutation
48 21226922 Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence
Mutation
49 18404209 Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses
Mutation
50 20523902 Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets
Mutation
51 20881092 Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5
Mutation
52 21345953 Effects of receptor binding specificity of avian influenza virus on the human innate immune response
Mutation
53 24889237 Enhanced human receptor binding by H5 haemagglutinins
Mutation
54 1700833 Overlapping cytotoxic T-lymphocyte and B-cell antigenic sites on the influenza virus H5 hemagglutinin
Mutation
55 39138310 Adaptation potential of H3N8 canine influenza virus in human respiratory cells
Mutation
56 25183443 Generation and characterization of influenza A viruses with altered polymerase fidelity
Mutation
57 36293269 Serial Passaging of Seasonal H3N2 Influenza A/Singapore/G2-31.1/2014 Virus in MDCK-SIAT1 Cells and Primary Chick Embryo Cells Generates HA D457G Mutation and Other Variants in HA, NA, PB1, PB1-F2, and NS1
Mutation
58 1830112 Intragenic suppression of a deletion mutation of the nonstructural gene of an influenza A virus
Mutation
59 9835519 Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071
Mutation
60 24239666 The effect of the MDCK cell selected neuraminidase D151G mutation on the drug susceptibility assessment of influenza A(H3N2) viruses
Mutation
61 25896455 The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding
Mutation
62 12062393 Influenza virus carrying neuraminidase with reduced sensitivity to oseltamivir carboxylate has altered properties in vitro and is compromised for infectivity and replicative ability in vivo
Mutation
63 15890915 Improvement of influenza A/Fujian/411/02 (H3N2) virus growth in embryonated chicken eggs by balancing the hemagglutinin and neuraminidase activities, using reverse genetics
Mutation
64 18684820 Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol
Mutation
65 21422222 Combinatorial effect of two framework mutations (E119V and I222L) in the neuraminidase active site of H3N2 influenza virus on resistance to oseltamivir
Mutation
66 24080660 Cell culture-selected substitutions in influenza A(H3N2) neuraminidase affect drug susceptibility assessment
Mutation
67 10982377 Recognition of N-glycolylneuraminic acid linked to galactose by the alpha2,3 linkage is associated with intestinal replication of influenza A virus in ducks
Mutation
68 20920297 Characterization of an H3N2 triple reassortant influenza virus with a mutation at the receptor binding domain (D190A) that occurred upon virus transmission from turkeys to pigs
Mutation
69 22564359 Effect of receptor specificity of A/Hong Kong/1/68 (H3N2) influenza virus variants on replication and transmission in pigs
Mutation
70 23994833 Mutation tryptophan to leucine at position 222 of haemagglutinin could facilitate H3N2 influenza A virus infection in dogs
Mutation
71 24074585 Mutation from arginine to lysine at the position 189 of hemagglutinin contributes to the antigenic drift in H3N2 swine influenza viruses
Mutation
72 2476569 Single-amino-acid substitution in an antigenic site of influenza virus hemagglutinin can alter the specificity of binding to cell membrane-associated gangliosides
Mutation
73 8553549 Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en
Mutation
74 8787876 Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en
Mutation
75 9499107 Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
Mutation
76 19014974 Aurintricarboxylic acid inhibits influenza virus neuraminidase
Mutation
77 38140689 Genomic Analysis of Influenza A and B Viruses Carrying Baloxavir Resistance-Associated Substitutions Serially Passaged in Human Epithelial Cells
Mutation
78 28477572 Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus
Mutation
79 20689744 The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase
Mutation
80 21116343 Does pandemic A/H1N1 virus have the potential to become more pathogenic?
Mutation
81 19019950 Avian Influenza A virus polymerase association with nucleoprotein, but not polymerase assembly, is impaired in human cells during the course of infection
Mutation
82 20303563 Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice
Mutation
83 20962098 PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza a viruses in mice
Mutation
84 22449422 Engineering temperature sensitive live attenuated influenza vaccines from emerging viruses
Mutation
85 23671418 Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model
Mutation
86 23799150 Asparagine substitution at PB2 residue 701 enhances the replication, pathogenicity, and transmission of the 2009 pandemic H1N1 influenza A virus
Mutation
87 24335306 PB2-588I enhances 2009 H1N1 pandemic influenza virus virulence by increasing viral replication and exacerbating PB2 inhibition of beta interferon expression
Mutation
88 22809692 Both influenza hemagglutinin and polymerase acidic genes are important for delayed pandemic 2009 H1N1 virus clearance in the ferret model
Mutation
89 23029425 Multiple distinct forms of CD8+ T cell cross-reactivity and specificities revealed after 2009 H1N1 influenza A virus infection in mice
Mutation
90 30518648 HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit
Mutation
91 33351916 Multiple polymerase acidic (PA) I38X substitutions in influenza A(H1N1)pdm09 virus permit polymerase activity and cause reduced baloxavir inhibition
Mutation
92 20970464 Structure-based design of NS2 mutants for attenuated influenza A virus vaccines
Mutation
93 35558132 The Interaction of Influenza A NS1 and Cellular TRBP Protein Modulates the Function of RNA Interference Machinery
Mutation
94 31864377 Changes in RNA secondary structure affect NS1 protein expression during early stage influenza virus infection
Mutation
95 24366752 A conformational restriction in the influenza A virus neuraminidase binding site by R152 results in a combinational effect of I222T and H274Y on oseltamivir resistance
Mutation
96 19857993 Evaluation of a rapid molecular algorithm for detection of pandemic influenza A (H1N1) 2009 virus and screening for a key oseltamivir resistance (H275Y) substitution in neuraminidase
Mutation
97 19893749 Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein
Mutation
98 20686654 Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets
Mutation
99 21047959 Genetic and phylogenetic analyses of influenza A H1N1pdm virus in Buenos Aires, Argentina
Mutation
100 21980293 Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets
Mutation
101 22174688 Role of permissive neuraminidase mutations in influenza A/Brisbane/59/2007-like (H1N1) viruses
Mutation
102 24155392 Evolution of the influenza A virus genome during development of oseltamivir resistance in vitro
Mutation
103 24524021 Generation and Characterization of Recombinant Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors
Mutation
104 24699865 Estimating the fitness advantage conferred by permissive neuraminidase mutations in recent oseltamivir-resistant A(H1N1)pdm09 influenza viruses
Mutation
105 25119465 Functional balance between the hemagglutinin and neuraminidase of influenza A(H1N1)pdm09 HA D222 variants
Mutation
106 30466301 Activity of enisamium, an isonicotinic acid derivative, against influenza viruses in differentiated normal human bronchial epithelial cells
Mutation
107 39086132 Dual neutralization of influenza virus hemagglutinin and neuraminidase by a bispecific antibody leads to improved antiviral activity
Mutation
108 24237039 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant
Mutation
109 24391498 A single amino acid in the stalk region of the H1N1pdm influenza virus HA protein affects viral fusion, stability and infectivity
Mutation
110 2033664 Single amino acid substitutions in the hemagglutinin can alter the host range and receptor binding properties of H1 strains of influenza A virus
Mutation
111 6224879 Influenza virus site recognized by a murine helper T cell specific for H1 strains. Localization to a nine amino acid sequence in the hemagglutinin molecule
Mutation
112 21060798 Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice
Mutation
113 21407805 A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets
Mutation
114 21458512 Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice
Mutation
115 23514882 Molecular basis of the receptor binding specificity switch of the hemagglutinins from both the 1918 and 2009 pandemic influenza A viruses by a D225G substitution
Mutation
116 24147093 Emerging antigenic variants at the antigenic site Sb in pandemic A(H1N1)2009 influenza virus in Japan detected by a human monoclonal antibody
Mutation
117 19893747 Novel pandemic influenza A(H1N1) viruses are potently inhibited by DAS181, a sialidase fusion protein
Mutation
118 39565117 LDC000067, a CDK9 inhibitor, unveils promising results in suppressing influenza virus infections in vitro and in vivo
Mutation
119 24566185 Fitness costs for Influenza B viruses carrying neuraminidase inhibitor-resistant substitutions: underscoring the importance of E119A and H274Y
Mutation
120 30201817 Characterization of Influenza B Virus Variants with Reduced Neuraminidase Inhibitor Susceptibility
Mutation
121 24503069 The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus
Mutation
122 28102191 A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
Mutation
123 19403683 Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice
Mutation
124 15613301 Involvement of influenza virus PA subunit in assembly of functional RNA polymerase complexes
Mutation
125 7605205 Amino acid replacements leading to temperature-sensitive defects of the NS1 protein of influenza A virus
Mutation
126 19454348 Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
Mutation
127 20926573 Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response
Mutation
128 22787231 Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses
Mutation
129 24928037 The R35 residue of the influenza A virus NS1 protein has minimal effects on nuclear localization but alters virus replication through disrupting protein dimerization
Mutation
130 8918554 Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme
Mutation
131 21466220 Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus
Mutation
132 8609159 Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells
Mutation
133 23536663 Substitutions T200A and E227A in the hemagglutinin of pandemic 2009 influenza A virus increase lethality but decrease transmission
Mutation
134 3003392 Variant influenza virus hemagglutinin that induces fusion at elevated pH
Mutation
135 1661731 Evidence from lateral mobility studies for dynamic interactions of a mutant influenza hemagglutinin with coated pits
Mutation
136 21816827 Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex
Mutation
137 8879138 Mutations in the hemagglutinin and matrix genes of a virulent influenza virus variant, A/FM/1/47-MA, control different stages in pathogenesis
Mutation
138 14645582 A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice
Mutation
139 2014635 Mutants and revertants of an avian influenza A virus with temperature-sensitive defects in the nucleoprotein and PB2
Mutation
140 18768984 Mutations at alternative 5' splice sites of M1 mRNA negatively affect influenza A virus viability and growth rate
Mutation
141 1448912 Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses
Mutation
142 19905033 Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus
Mutation
143 38543924 MDCK-Adaptive Mutation of A169S Changes Glycosylation Pattern of Hemagglutinin and Enhances MDCK-Based H7N9 Vaccine Virus Production without Loss of Antigenicity and Immunogenicity
Mutation
144 37373148 RNA Overwriting of Cellular mRNA by Cas13b-Directed RNA-Dependent RNA Polymerase of Influenza A Virus
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.