Overview of ZIKV associated Cell line (Mutation)

ID Literature Title Group
1 35891552 A Reverse Mutation E143K within the PrM Protein of Zika Virus Asian Lineage Natal RGN Strain Increases Infectivity and Cytopathicity
Mutation
2 36840584 Key Residue in the Precursor Region of M Protein Contributes to the Neurovirulence and Neuroinvasiveness of the African Lineage of Zika Virus
Mutation
3 34327243 The Ablation of Envelope Protein Glycosylation Enhances the Neurovirulence of ZIKV and Cell Apoptosis in Newborn Mice
Mutation
4 30886357 Determinants of Zika virus host tropism uncovered by deep mutational scanning
Mutation
5 37832876 Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein
Mutation
6 30391636 Analysis of cellular proteome changes in response to ZIKV NS2B-NS3 protease expression
Mutation
7 34699863 Optimal flexibility of the linker region of Zika virus NS5 methyltransferase-polymerase is critical for virus replication
Mutation
8 36271143 Adaptation to host cell environment during experimental evolution of Zika virus
Mutation
9 34910902 Dysregulated metabolism underpins Zika-virus-infection-associated impairment in fetal development
Mutation
10 28174309 Understanding Zika Virus Stability and Developing a Chimeric Vaccine through Functional Analysis
Mutation
11 28196656 A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine
Mutation
12 28069884 Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors
Mutation
13 33800884 Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro
Mutation
14 34282707 LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination
Mutation
15 31434319 Attenuation of Zika Virus by Passage in Human HeLa Cells
Mutation
16 34608212 Leu-to-Phe substitution at prM(146) decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice
Mutation
17 33198111 Single Amino Acid Mutations Affect Zika Virus Replication In Vitro and Virulence In Vivo
Mutation
18 32842538 N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle
Mutation
19 31757867 Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge
Mutation
20 34620704 A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host
Mutation
21 30144463 Novel genetically stable infectious clone for a Zika virus clinical isolate and identification of RNA elements essential for virus production
Mutation
22 33052957 Reversion to ancestral Zika virus NS1 residues increases competence of Aedes albopictus
Mutation
23 37068347 Tissue-specific expansion of Zika virus isogenic variants drive disease pathogenesis
Mutation
24 28514450 Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes
Mutation
25 32924767 Zika virus NS2A protein induces the degradation of KPNA2 (karyopherin subunit alpha 2) via chaperone-mediated autophagy
Mutation
26 36367083 Characterization and phylogenetic analysis of a neurovirulent Zika virus isolated from Cambodia in 2019
Mutation
27 33753816 Single dose of a replication-defective vaccinia virus expressing Zika virus-like particles is protective in mice
Mutation
28 32747564 A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission
Mutation
29 31138647 Characterization of two engineered dimeric Zika virus envelope proteins as immunogens for neutralizing antibody selection and vaccine design
Mutation
30 39986659 Mutation S139N on Zika virus prM protein shifts immune response from Asian to contemporary strain
Mutation
31 30995223 Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission
Mutation
32 37747060 Asian Zika virus can acquire generic African-lineage mutations during in utero infection
Mutation
33 37884553 A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype
Mutation
34 31547297 An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model
Mutation
35 32763144 The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis
Mutation
36 38166143 Identification of a critical role for ZIKV capsid alpha3 in virus assembly and its genetic interaction with M protein
Mutation
37 39412258 An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice
Mutation
38 30403995 A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates
Mutation
39 30845254 Shortening of Zika virus CD-loop reduces neurovirulence while preserving antigenicity
Mutation
40 40291117 Evolution of Zika virus in Rag1-deficient mice selects for unique envelope glycosylation motif mutants that show enhanced replication fitness
Mutation
41 29379028 An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
Mutation
42 40062839 A single mutation in the PrM gene of Zika virus determines AXL dependency for infection of human neural cells
Mutation
43 36768218 Identification of Potent Zika Virus NS5 RNA-Dependent RNA Polymerase Inhibitors Combining Virtual Screening and Biological Assays
Mutation
44 33718276 Functional Mapping of AGO-Associated Zika Virus-Derived Small Interfering RNAs in Neural Stem Cells
Mutation
45 35575481 Somatic Hypermutation and Framework Mutations of Variable Region Contribute to Anti-Zika Virus-Specific Monoclonal Antibody Binding and Function
Mutation
46 30763872 Mutations present in a low-passage Zika virus isolate result in attenuated pathogenesis in mice
Mutation
47 35793354 Zika virus-like particle vaccine fusion loop mutation increases production yield but fails to protect AG129 mice against Zika virus challenge
Mutation
48 35234632 A single nonsynonymous mutation on ZIKV E protein-coding sequences leads to markedly increased neurovirulence in vivo
Mutation
49 31238493 A Chimeric Zika Virus between Viral Strains MR766 and BeH819015 Highlights a Role for E-glycan Loop in Antibody-mediated Virus Neutralization
Mutation
50 29091758 Functional Analysis of Glycosylation of Zika Virus Envelope Protein
Mutation
51 32796074 Two Genetic Differences between Closely Related Zika Virus Strains Determine Pathogenic Outcome in Mice
Mutation
52 31043537 Human Monoclonal Antibodies Potently Neutralize Zika Virus and Select for Escape Mutations on the Lateral Ridge of the Envelope Protein
Mutation
53 29170504 Characterization of large and small-plaque variants in the Zika virus clinical isolate ZIKV/Hu/S36/Chiba/2016
Mutation
54 34745057 Rapid Construction of an Infectious Clone of the Zika Virus, Strain ZKC2
Mutation
55 37800949 Gain without pain: adaptation and increased virulence of Zika virus in vertebrate host without fitness cost in mosquito vector
Mutation
56 31662457 Zika Virus NS2A-Mediated Virion Assembly
Mutation
57 32999034 Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors
Mutation
58 35417697 A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity
Mutation
59 31815005 An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses
Mutation
60 32699085 NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells
Mutation
61 36968111 Replication in the presence of dengue convalescent serum impacts Zika virus neutralization sensitivity and fitness
Mutation
62 33910950 A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice
Mutation
63 34757841 Structurally Conserved Domains between Flavivirus and Alphavirus Fusion Glycoproteins Contribute to Replication and Infectious-Virion Production
Mutation
64 30301244 An Alanine-to-Valine Substitution in the Residue 175 of Zika Virus NS2A Protein Affects Viral RNA Synthesis and Attenuates the Virus In Vivo
Mutation
65 35536870 The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential
Mutation
66 31882898 A natural polymorphism in Zika virus NS2A protein responsible of virulence in mice
Mutation
67 32056710 Zika virus NS5 nuclear accumulation is protective of protein degradation and is required for viral RNA replication
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.