Overview of HCMV associated Cytomegalovirus infections

ID Literature Title Group
1 9721800 Ganciclovir resistance as a result of oral ganciclovir in a heart transplant recipient with multiple human cytomegalovirus strains in blood
Mutation
2 11160752 Infrequent occurrence of natural mutations in the pp65(495-503) epitope sequence presented by the HLA A*0201 allele among human cytomegalovirus isolates
Mutation
3 11505446 Aciclovir selects for ganciclovir-cross-resistance of human cytomegalovirus in vitro that is only in part explained by known mutations in the UL97 protein
Mutation
4 11888658 Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system
Mutation
5 14739146 Human cytomegalovirus double resistance in a donor-positive/recipient-negative lung transplant patient with an impaired CD4-mediated specific immune response
Mutation
6 15793144 Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient
Mutation
7 16000504 Fatal reactivation of postnatal cytomegalovirus infection with rapid emergence of ganciclovir resistance in an infant after allogeneic stem cell transplantation
Mutation
8 16962820 Maribavir sensitivity of cytomegalovirus isolates resistant to ganciclovir, cidofovir or foscarnet
Mutation
9 17112867 Prevalence of human cytomegalovirus UL97 D605E mutation in transplant recipients in China
Mutation
10 17157554 Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients
Mutation
11 17161359 The emergence of cytomegalovirus resistance to ganciclovir therapy in kidney transplant recipients
Mutation
12 17538888 Cytomegalovirus UL97 kinase mutations that confer maribavir resistance
Mutation
13 17605746 Viral monitoring and successful treatment of a ganciclovir-resistant cytomegalovirus infection in a heart transplant recipient
Mutation
14 17709468 Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens
Mutation
15 18419454 Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation
Mutation
16 19147520 Valganciclovir as pre-emptive therapy for cytomegalovirus infection post-allogenic stem cell transplantation: implications for the emergence of drug-resistant cytomegalovirus
Mutation
17 19152402 Successful valganciclovir treatment of post-transplant cytomegalovirus infection in the presence of UL97 mutation N597D
Mutation
18 19812447 Genetic analysis and putative role in resistance to antivirals of the human cytomegalovirus DNA polymerase UL44 processivity factor
Mutation
19 20138805 Incidence and characterization of cytomegalovirus resistance mutations among pediatric solid organ transplant patients who received valganciclovir prophylaxis
Mutation
20 20504236 Virologic characterization of multidrug-resistant cytomegalovirus infection in 2 transplant recipients treated with maribavir
Mutation
21 21070537 Diversity of antiviral-resistant human cytomegalovirus in heart and lung transplant recipients
Mutation
22 21199205 The role of cytomegalovirus infection and disease in pediatric bone marrow transplant recipients in Mexico City in the context of viral drug resistance
Mutation
23 21362026 Human cytomegalovirus UL97 D605E polymorphism has a high prevalence in immunocompetent Japanese infants and children
Mutation
24 22237003 Incidence of cytomegalovirus UL97 and UL54 amino acid substitutions detected after 100 or 200 days of valganciclovir prophylaxis
Mutation
25 22293247 Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene
Mutation
26 22300656 Detection of ganciclovir resistance mutations by pyrosequencing in HCMV-infected pediatric patients
Mutation
27 22381918 Multiple ganciclovir-resistant strains in a newborn with symptomatic congenital human cytomegalovirus infection
Mutation
28 22664236 Effects on maribavir susceptibility of cytomegalovirus UL97 kinase ATP binding region mutations detected after drug exposure in vitro and in vivo
Mutation
29 22939665 Lack of resistance-associated mutations in UL54 and UL97 genes of circulating cytomegalovirus strains isolated in a medical center in Taiwan
Mutation
30 23011309 A new mutation in the human cytomegalovirus UL97 gene may confer ganciclovir resistance in Chinese kidney transplant recipients
Mutation
31 23195018 Human cytomegalovirus (CMV) UL97 D605E mutation has a higher prevalence in infants with primary CMV infection compared with transplant recipients with CMV recurrence
Mutation
32 23198963 Cytomegalovirus infection and ganciclovir resistance caused by UL97 mutations in pediatric transplant recipients
Mutation
33 23415883 Novel DNA polymerase mutations conferring cytomegalovirus resistance: input of BAC-recombinant phenotyping and 3D model
Mutation
34 23546999 Successful ganciclovir treatment of primary cytomegalovirus infection containing the UL97 mutation N510S in an intestinal graft recipient
Mutation
35 23592041 Rapid detection and quantitation of ganciclovir resistance in cytomegalovirus quasispecies
Mutation
36 23688863 Emergence of antiviral resistance during oral valganciclovir treatment of an infant with congenital cytomegalovirus (CMV) infection
Mutation
37 23727806 Detection of human cytomegalovirus UL97 D605E mutation in Korean stem cell transplantation recipients and donors
Mutation
38 24183928 Dynamics of cytomegalovirus populations harbouring mutations in genes UL54 and UL97 in a haematopoietic stem cell transplant recipient
Mutation
39 24273181 Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial
Mutation
40 24752100 [Drug susceptibility and UL97 gene mutation analysis of cytomegalovirus in recipients of hematopoietic stem cell transplantation]
Mutation
41 25130511 Detecting human cytomegalovirus drug resistant mutations and monitoring the emergence of resistant strains using real-time PCR
Mutation
42 25143583 Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping
Mutation
43 25405808 The impact of drug-resistant cytomegalovirus in pediatric allogeneic hematopoietic cell transplant recipients: a prospective monitoring of UL97 and UL54 gene mutations
Mutation
44 25968338 Detection of Two Drug-Resistance Mutants of the Cytomegalovirus by High-Resolution Melting Analysis
Mutation
45 26113373 Characterization of Cytomegalovirus Breakthrough Events in a Phase 2 Prophylaxis Trial of Letermovir (AIC246, MK 8228)
Mutation
46 26448304 [Ganciclovir treatment failure in adult allogeneic hematopoietic stem cell transplant recipients with cytomegalovirus infection--a single centre experience]
Mutation
47 27214758 Contribution of next generation sequencing to early detection of cytomegalovirus UL97 emerging mutants and viral subpopulations analysis in kidney transplant recipients
Mutation
48 27540455 Assessment of the Human Cytomegalovirus UL97 Gene for Identification of Resistance to Ganciclovir in Iranian Immunosuppressed Patients
Mutation
49 27667983 Detection of Low Frequency Multi-Drug Resistance and Novel Putative Maribavir Resistance in Immunocompromised Pediatric Patients with Cytomegalovirus
Mutation
50 27743434 Molecular Analysis of Ganciclovir-Resistant Cytomegalovirus in Renal Transplant Recipients with High Viral Load
Mutation
51 27753183 Tolerability of up to 200 days of prophylaxis with valganciclovir oral solution and/or film-coated tablets in pediatric kidney transplant recipients at risk of cytomegalovirus disease
Mutation
52 27887982 Genotypic resistance of cytomegalovirus to antivirals in hematopoietic stem cell transplant recipients from Portugal: A retrospective study
Mutation
53 28979335 Incidence of Ganciclovir Resistance in CMV-positive Renal Transplant Recipients and its Association with UL97 Gene Mutations
Mutation
54 29746444 Role of letermovir for prevention of cytomegalovirus infection after allogeneic haematopoietic stem cell transplantation
Mutation
55 29989279 Letermovir successfully used for secondary prophylaxis in a heart transplant recipient with ganciclovir-resistant cytomegalovirus syndrome (UL97 mutation)
Mutation
56 30174240 Analysis of relationships between polymorphisms in the genes encoding the pentameric complex and neutralization of clinical cytomegalovirus isolates
Mutation
57 30286286 Emergence of letermovir resistance in a lung transplant recipient with ganciclovir-resistant cytomegalovirus infection
Mutation
58 30577289 Persistent Primary Cytomegalovirus Infection After Deceased Donor Kidney Transplant: Ganciclovir Susceptibility of Human Cytomegalovirus With UL97 D605E Mutation: A Case Report
Mutation
59 30671207 In Vivo Emergence of UL56 C325Y Cytomegalovirus Resistance to Letermovir in a Patient with Acute Myeloid Leukemia after Hematopoietic Cell Transplantation
Mutation
60 31068147 Fast breakthrough of resistant cytomegalovirus during secondary letermovir prophylaxis in a hematopoietic stem cell transplant recipient
Mutation
61 31262766 Patient-Derived Cytomegaloviruses with Different Ganciclovir Sensitivities from UL97 Mutation Retain Their Replication Efficiency and Some Kinase Activity In Vitro
Mutation
62 31532960 Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation
Mutation
63 31568799 Novel UL97 drug resistance mutations identified at baseline in a clinical trial of maribavir for resistant or refractory cytomegalovirus infection
Mutation
64 31781762 Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients
Mutation
65 31802131 De Novo Genotypic Heterogeneity in the UL56 Region in Cytomegalovirus-Infected Tissues: Implications for Primary Letermovir Resistance
Mutation
66 32035273 Letermovir for Secondary Prophylaxis of Cytomegalovirus Infection and Disease after Allogeneic Hematopoietic Cell Transplantation: Results from the French Compassionate Program
Mutation
67 32612959 Whole-Genome Approach to Assessing Human Cytomegalovirus Dynamics in Transplant Patients Undergoing Antiviral Therapy
Mutation
68 32726419 Drug Resistance Mutations and Associated Phenotypes Detected in Clinical Trials of Maribavir for Treatment of Cytomegalovirus Infection
Mutation
69 33210830 Emergence of letermovir resistance in solid organ transplant recipients with ganciclovir resistant cytomegalovirus infection: A case series and review of the literature
Mutation
70 33475730 Phenotype and Genotype Study of Novel C480F Maribavir-Ganciclovir Cross-Resistance Mutation Detected in Hematopoietic Stem Cell and Solid Organ Transplant Recipients
Mutation
71 33632621 Molecular Epidemiology of Cytomegalovirus UL97 and UL54 variants in Taiwan
Mutation
72 33966176 Cytomegalovirus Infection and the Implications of Drug-Resistant Mutations in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Retrospective Study from a Tertiary Hospital in China
Mutation
73 34118118 Letermovir in lung transplant recipients with cytomegalovirus infection: A retrospective observational study
Mutation
74 34211066 Prevalence of UL97 gene mutations and polymorphisms in cytomegalovirus infection in the colon associated with or without ulcerative colitis
Mutation
75 34273445 Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing
Mutation
76 34556034 Emergence of Letermovir-resistant HCMV UL56 mutant during rescue treatment in a liver transplant recipient with ganciclovir-resistant infection HCMV: a case report
Mutation
77 34660835 Development and Dynamics of Cytomegalovirus UL97 Ganciclovir Resistance Mutations in Transplant Recipients Detected by Next-Generation Sequencing
Mutation
78 34704798 Sequencing Directly from Clinical Specimens Reveals Genetic Variations in HCMV-Encoded Chemokine Receptor US28 That May Influence Antibody Levels and Interactions with Human Chemokines
Mutation
79 35343771 Assessment of UL56 Mutations before Letermovir Therapy in Refractory Cytomegalovirus Transplant Recipients
Mutation
80 35563032 Sequencing of the Viral UL111a Gene Directly from Clinical Specimens Reveals Variants of HCMV-Encoded IL-10 That Are Associated with Altered Immune Responses to HCMV
Mutation
81 35690130 First clinical description of letermovir resistance mutation in cytomegalovirus UL51 gene and potential impact on the terminase complex structure
Mutation
82 35733089 Detection of antiviral drug resistance in patients with congenital cytomegalovirus infection using long-read sequencing: a retrospective observational study
Mutation
83 35907059 Cytomegalovirus UL97 ganciclovir resistance mutations in kidney transplant recipients
Mutation
84 35993155 Genotypic and Phenotypic Study of Antiviral Resistance Mutations in Refractory Cytomegalovirus Infection
Mutation
85 36170912 Relative frequency of cytomegalovirus UL56 gene mutations detected in genotypic letermovir resistance testing
Mutation
86 36361707 Variants of HCMV UL18 Sequenced Directly from Clinical Specimens Associate with Antibody and T-Cell Responses to HCMV
Mutation
87 36693927 Cytomegalovirus breakthrough and resistance during letermovir prophylaxis
Mutation
88 37462304 [Investigation of Ganciclovir Resistance in Cytomegalovirus Isolates by Phenotypic and Genotypic Methods]
Mutation
89 37464399 Cytomegalovirus drug resistance mutations in transplant recipients with suspected resistance
Mutation
90 37466088 Pharmacokinetic analysis driven letermovir dosing in pediatric hematopoietic cell transplantation patients with resistant CMV disease
Mutation
91 37506264 Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients
Mutation
92 37566984 Application of the ViroKey(R) SQ FLEX assay for detection of cytomegalovirus antiviral resistance
Mutation
93 37724822 Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Mutation
94 37902387 Real-life experience in two cases of secondary prophylaxis with letermovir for CMV infection in solid organ transplantation
Mutation
95 38880196 Phenotypes of cytomegalovirus genetic variants encountered in a letermovir clinical trial illustrate the importance of genotyping validation
Mutation
96 39527767 Mutations in human cytymegalovirus (Orthoherpesviridae: Herpesvirales: Cytomegalovirus: Cytomegalovirus humanbeta 5) UL97 gene lead to increase in viremia duration and poor antiviral response in recipients of allogeneic hematopoietic stem cells
Mutation
97 39857098 Ganciclovir Resistance-Linked Mutations in the HCMV UL97 Gene: Sanger Sequencing Analysis in Samples from Transplant Recipients at a Tertiary Hospital in Southern Brazil
Mutation
98 40143348 Dual Resistance to Maribavir and Ganciclovir in Transplant Recipients
Mutation
99 9037377 Comparison of human cytomegalovirus (HCMV) protease sequences among laboratory strains and seven clinical isolates
Mutation
100 16856628 A novel mutation in the UL54 gene of human cytomegalovirus isolates that confers resistance to foscarnet
Mutation
101 17043128 Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates
Mutation
102 21041510 Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility
Mutation
103 35810104 Intra-host diversity of drug-resistant cytomegalovirus: A case report of cytomegalovirus infection after allogeneic hematopoietic cell transplantation
Mutation
104 19712701 Single and multiple mutations in the human cytomegalovirus UL97 gene and their relationship to the enzymatic activity of UL97 kinase for ganciclovir phosphorylation
Mutation