ViMIC2.0 Database

1

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

Mutation

2

Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma

Mutation

3

8051279

Identification of human cytomegalovirus strain with immediate-early (IE) antigen-specific monoclonal antibody is prevented by point mutation in IE gene

Mutation

4

8627655

Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS

Mutation

5

9037377

Comparison of human cytomegalovirus (HCMV) protease sequences among laboratory strains and seven clinical isolates

Mutation

6

9389413

Development of a point mutation assay for the detection of human cytomegalovirus UL97 mutations associated with ganciclovir resistance

Mutation

7

9527804

The Cys607-->Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients

Mutation

8

11595579

Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity

Mutation

9

11750939

GCV resistance due to the mutation A594P in the cytomegalovirus protein UL97 is partially reconstituted by a second mutation at D605E

Mutation

10

15230476

Ganciclovir resistance mutations in UL97 and UL54 genes of Human cytomegalovirus isolates resistant to ganciclovir

Mutation

11

20587851

Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity

Mutation

12

9697736

Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy

Mutation