Overview of HBV associated Hepatitis B, Chronic

ID Literature Title Group
1 24992206 Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection
Mutation
2 25028473 Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility
Mutation
3 25061278 Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir
Mutation
4 25132017 The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil
Mutation
5 25170961 Correlation between the promoter basal core and precore mutations and HBsAg quantification in French blood donors infected with hepatitis B virus
Mutation
6 25208639 Performance of LigAmp assay for sensitive detection of drug-resistant hepatitis B virus minor variants in comparison with standard nucleotide sequencing
Mutation
7 25244642 Hepatitis B virus depicts a high degree of conservation during the immune-tolerant phase in familiarly transmitted chronic hepatitis B infection: deep-sequencing and phylogenetic analysis
Mutation
8 25287170 Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B
Mutation
9 25303802 Different mechanism of selection of adefovir-resistant mutant viruses during adefovir monotherapy in patients with lamivudine-resistant chronic hepatitis B
Mutation
10 25374716 Death from Liver Failure despite Lamivudine Prophylaxis during R-CHOP Chemotherapy due to Rapid Emergence M204 Mutations
Mutation
11 25382636 A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians
Mutation
12 25452041 Specific mutations in the C-terminus domain of HBV surface antigen significantly correlate with low level of serum HBV-DNA in patients with chronic HBV infection
Mutation
13 25477976 Hepatitis B virus core promoter mutations in patients with chronic hepatitis B and hepatocellular carcinoma in bucharest, romania
Mutation
14 25626648 Hepatitis B virus genotypes and mutations in the basal core promoter and pre-core/core in chronically infected patients in southern Brazil: a cross-sectional study of HBV genotypes and mutations in chronic carriers
Mutation
15 25732900 New amino acid changes in drug resistance sites and HBsAg in hepatitis B virus genotype H
Mutation
16 25742145 Clinical course of chronic hepatitis B patients receiving nucleos(t)ide analogues after virological breakthrough during monotherapy with lamivudine
Mutation
17 25788956 Association of Mutations in the Basal Core Promoter and Pre-core Regions of the Hepatitis B Viral Genome and Longitudinal Changes in HBV Level in HBeAg Negative Individuals: Results From a Cohort Study in Northern Iran
Mutation
18 25817219 Characterization of novel entecavir resistance mutations
Mutation
19 25822176 Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients
Mutation
20 25825644 Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients
Mutation
21 25982306 Microarray-based genotyping and detection of drug-resistant HBV mutations from 620 Chinese patients with chronic HBV infection
Mutation
22 26164128 Comparison of entecavir monotherapy and de novo lamivudine and adefovir combination therapy in HBeAg-positive chronic hepatitis B with high viral load: 48-week result
Mutation
23 26201521 Naturally occurring core immune-escape and carboxy-terminal mutations truncations in patients with e antigen negative chronic hepatitis B
Mutation
24 26202027 HBsAg, HBeAg and HBV DNA level changes and precore/basal core promoter mutations in the natural history of chronic hepatitis B in Indonesian patients
Mutation
25 26288490 Distribution of hepatitis B virus genotype and cancer predicting precore and basal core promoter mutations
Mutation
26 26309637 Detection and analysis of resistance mutations of hepatitis B virus
Mutation
27 26382925 Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment
Mutation
28 26389515 Predictors of hepatitis B e antigen-negative hepatitis in chronic hepatitis B virus-infected patients from childhood to adulthood
Mutation
29 26505028 A Nanoscale Mutation-Sensitive On/Off Switch Based Assays for the Detection of Hepatitis B Virus Lamivudine-Resistant Mutations
Mutation
30 26571304 Chronic hepatitis B in pregnant women: is hepatitis B surface antigen quantification useful for viral load prediction?
Mutation
31 26571502 Virological Characteristics of Acute Hepatitis B in Eastern India: Critical Differences with Chronic Infection
Mutation
32 26587040 G1896A Precore Mutation and Association With HBeAg Status, Genotype and Clinical Status in Patients With Chronic Hepatitis B
Mutation
33 26613893 Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs
Mutation
34 26647737 Deep sequencing of hepatitis B virus basal core promoter and precore mutants in HBeAg-positive chronic hepatitis B patients
Mutation
35 26727850 GENOMIC ANALYSIS OF HEPATITIS B VIRUS STRAINS INFECTING ROMANIAN PATIENTS
Mutation
36 26825915 Dynamics of Genotypic Mutations of the Hepatitis B Virus Associated With Long-Term Entecavir Treatment Determined With Ultradeep Pyrosequencing: A Retrospective Observational Study
Mutation
37 26831605 Antiviral efficacy of entecavir versus entecavir plus adefovir for hepatitis B virus rtA181V/T mutants alone
Mutation
38 26876337 Prevalence of mutations in HBV DNA polymerase gene associated with nucleos(t)ide resistance in treatment-naive patients with Chronic Hepatitis B in Central China
Mutation
39 26889227 Evolution of entecavir-resistant hepatitis B virus during entecavir and adefovir dipivoxil combination therapy
Mutation
40 26901602 Investigation by the Method of INNO-LiPA of Primary Resistance to Lamivudine in Patients with Chronic Hepatitis B Who Have Not Used Antiviral Therapy
Mutation
41 26992056 Different precore/core mutations of hepatitis B interact with, limit, or favor liver fibrosis severity
Mutation
42 27006281 Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2
Mutation
43 27055927 Prevalence of mutations within major hydrophilic region of hepatitis B virus and their correlation with genotypes among chronically infected patients in Egypt
Mutation
44 27340355 Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma
Mutation
45 27446286 Association between clinical features and YMDD mutations in patients with chronic hepatitis B following lamivudine therapy
Mutation
46 27504160 Mutational analysis of reverse transcriptase and surface proteins of patients with partial virological response during mono and combination antiviral therapies in genotype D chronic hepatitis B
Mutation
47 27535686 Detection of Anti-Hepatitis B Virus Drug Resistance Mutations Based on Multicolor Melting Curve Analysis
Mutation
48 27544241 Naturally Occurring Surface Antigen Variants of Hepatitis B Virus in Tunisian Patients
Mutation
49 27583985 Small surface antigen variants of HBV associated with responses to telbivudine treatment in chronic hepatitis B patients
Mutation
50 27650283 Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA
Mutation
51 27651827 Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo
Mutation
52 27787680 Identification of a new hepatitis B virus recombinant D2/D3 in the city of Sao Paulo, Brazil
Mutation
53 27812178 Evaluation of the G145R Mutant of the Hepatitis B Virus as a Minor Strain in Mother-to-Child Transmission
Mutation
54 27824315 Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naive patients
Mutation
55 27894395 Relationship between hepatitis B virus reverse transcriptase 181 mutation and S gene mutation in hepatitis B virus chronically infected patients
Mutation
56 27998820 Core I97L mutation in conjunction with P79Q is associated with persistent low HBV DNA and HBs antigen clearance in patients with chronic hepatitis B
Mutation
57 28103819 Telbivudine versus entecavir in patients with undetectable hepatitis B virus DNA: a randomized trial
Mutation
58 28139541 Comparative evaluation of long-term monotherapies & combination therapies in patients with chronic hepatitis B: A pilot study
Mutation
59 28152517 Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro
Mutation
60 28198078 Mutation in the S gene of hepatitis B virus and anti-HBs subtype-nonspecificity contributed to the co-existence of HBsAg and anti-HBs in patients with chronic hepatitis B virus infection
Mutation
61 28236303 Characterization of hepatitis B virus (HBV) preS/S gene mutations in blood donors with occult HBV infection in the Baoji area of North China
Mutation
62 28300730 The enrichment of HBV immune-escape mutations during nucleoside/nucleotide analogue therapy
Mutation
63 28303969 HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy
Mutation
64 28322924 Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002-2012) of different treatment regimens: The legacy of lamivudine/adefovir combination treatment
Mutation
65 28376852 Antiviral efficacy of entecavir for hepatitis B virus rtA181V/T mutants
Mutation
66 28381384 Novel HBV mutations and their value in predicting efficacy of conventional interferon
Mutation
67 28418295 Phenotypic and Genotypic Shifts in Hepatitis B Virus in Treatment-Naive Patients, Taiwan, 2008-2012
Mutation
68 28440785 Impacts of HBV rtH55R polymerase substitution on viral replication and rtM204I/V resistance to nucleoside/nucleotide antiviral drugs
Mutation
69 28445403 Detection of Hepatitis B Virus M204I Mutation by Quantum Dot-Labeled DNA Probe
Mutation
70 28500726 Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection
Mutation
71 28600703 Prevalence of S gene mutations within the major hydrophilic region of hepatitis B virus in patients in Dongguan, southern China
Mutation
72 28740410 Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B
Mutation
73 28859616 Molecular characterization of hepatitis B virus in Vietnam
Mutation
74 28870025 Clinical characteristics of patients with chronic hepatitis B who developed genotypic resistance to entecavir: Real-life experience
Mutation
75 29353073 Serum HBV DNA plus RNA shows superiority in reflecting the activity of intrahepatic cccDNA in treatment-naive HBV-infected individuals
Mutation
76 29393485 Early changes in quasispecies variant after antiviral therapy for chronic hepatitis B
Mutation
77 29596494 High rates of chronic HBV genotype E infection in a group of migrants in Italy from West Africa: Virological characteristics associated with poor immune clearance
Mutation
78 29663445 Mutations within the major hydrophilic region (MHR) of Hepatitis B virus from individuals with simultaneous HBsAg and anti-HBs in Guangzhou, Southern China
Mutation
79 29859062 Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe
Mutation
80 30095435 Association of characteristics of HBV quasispecies with hepatitis B surface antigen seroconversion after pegylated interferon-alpha-2a treatment in child patients
Mutation
81 30285571 Predictors of Therapeutic Outcome to Nucleotide Reverse Transcriptase Inhibitor in Hepatitis B Patients
Mutation
82 30586543 Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model
Mutation
83 30669266 Naturally Occurring Mutations within HBV Surface Promoter II Sequences Affect Transcription Activity, HBsAg and HBV DNA Levels in HBeAg-Positive Chronic Hepatitis B Patients
Mutation
84 30794889 Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients
Mutation
85 30796932 Prevalence of the entecavir-resistance-inducing mutation rtA186T in a large cohort of Chinese hepatitis B virus patients
Mutation
86 30835025 Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation
Mutation
87 30867996 Patterns of hepatitis B virus S gene escape mutants and reverse transcriptase mutations among genotype D isolates in Jordan
Mutation
88 30906435 Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy
Mutation
89 31179360 Hepatitis B virus reverse transcriptase polymorphisms between treated and treatment-naive chronically infected patients
Mutation
90 31189581 Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing
Mutation
91 31308922 Nucleotide Substitutions in Hepatitis B Viruses Derived from Chronic HBV Patients
Mutation
92 31324819 Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients
Mutation
93 31359359 Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B
Mutation
94 31398372 Investigation of hepatitis B virus (HBV) rtS78T/sC69* mutation in a large cohort of chronic HBV-infected patients with nucleoside/nucleotide analogue treatment
Mutation
95 31402915 rt269I Type of Hepatitis B Virus (HBV) Leads to HBV e Antigen Negative Infections and Liver Disease Progression via Mitochondrial Stress Mediated Type I Interferon Production in Chronic Patients With Genotype C Infections
Mutation
96 31442597 The modulation of HBsAg level by sI126T is affected by additional amino acid substitutions in the S region of HBV
Mutation
97 31498528 Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance
Mutation
98 31543688 Tenofovir is a more suitable treatment than entecavir for chronic hepatitis B patients carrying naturally occurring rtM204I mutations
Mutation
99 31624004 Characteristics of amino acid substitutions within the "a" determinant region of hepatitis B virus in chronically infected patients with coexisting HBsAg and anti-HBs
Mutation
100 31731368 Compare with safety and efficacy of entecavir and adefovir dipivoxil combination therapy and tenofovir disoproxil fumarate monotherapy for chronic hepatitis B patient with adefovir-resistant
Mutation
101 32189364 Rapid Turnover of Hepatitis B Virus Covalently Closed Circular DNA Indicated by Monitoring Emergence and Reversion of Signature-Mutation in Treated Chronic Hepatitis B Patients
Mutation
102 32216026 Entecavir-resistant hepatitis B virus decreases surface antigenicity: A full genome and functional characterization
Mutation
103 32312174 Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection
Mutation
104 32466635 Low-level viremia and cirrhotic complications in patients with chronic hepatitis B according to adherence to entecavir
Mutation
105 32569703 Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients
Mutation
106 32579776 Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy
Mutation
107 32663786 Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults
Mutation
108 32695898 In silico functional and structural characterization of hepatitis B virus PreS/S-gene in Iranian patients infected with chronic hepatitis B virus genotype D
Mutation
109 32708399 COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B
Mutation
110 32765014 Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues
Mutation
111 32840739 An antiviral drug-resistant mutant of hepatitis B virus with high replication capacity in association with a large in-frame deletion in the preS1 region of viral surface gene
Mutation
112 32860463 Precore and Basal Core Promoter Hepatitis B Virus (HBV) Variants Are Present From a Young Age and Differ Across HBV Genotypes
Mutation
113 32994690 Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations
Mutation
114 33124952 Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients
Mutation
115 33462964 Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir
Mutation
116 33562603 Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes
Mutation
117 33571155 Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients
Mutation
118 33603102 Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients
Mutation
119 33671832 Predominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitis
Mutation
120 33708042 Hepatitis B virus precore/core region mutations and genotypes among hepatitis B virus chronic carriers in South-Eastern, Nigeria
Mutation
121 33758517 The Occurrence of rtA194T Mutant After Long-Term Lamivudine Monotherapy Remains Sensitive to Tenofovir Disoproxil Fumarate: A Case Report
Mutation
122 33791326 Tenofovir Disoproxil Fumarate Is Superior to Entecavir in Reducing Hepatitis B Surface Antigen for Chronic Hepatitis B in China: 2-Year Comprehensive Comparative Result of a Matched Comparative Study
Mutation
123 33836203 Natural variability in surface antigen and reverse transcriptase domain of hepatitis B virus in treatment-naive chronic HBV-infected Egyptian patients
Mutation
124 33986897 High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy
Mutation
125 34002910 Hepatitis B virus genome diversity in adolescents: Tenofovir disoproxil fumarate treatment effect and HBeAg serocon version
Mutation
126 34007795 Detection of Hepatitis B Virus M204V Mutation Quantitatively via Real-time PCR
Mutation
127 34111075 Molecular characterization of hepatitis B virus basal core promoter and precore region of isolates from chronic hepatitis B patients
Mutation
128 34319801 Fast and Sensitive Real-Time PCR Detection of Major Antiviral-Drug Resistance Mutations in Chronic Hepatitis B Patients by Use of a Predesigned Panel of Locked-Nucleic-Acid TaqMan Probes
Mutation
129 34352407 Amino Acid Polymorphism in Hepatitis B Virus Associated With Functional Cure
Mutation
130 34951036 Combining the HBcrAg decline and HBV mutations predicts spontaneous HBeAg seroconversion in chronic hepatitis B patients during the immune clearance phase
Mutation
131 35203489 Identification and Characterization of Besifovir-Resistant Hepatitis B Virus Isolated from a Chronic Hepatitis B Patient
Mutation
132 35293188 [Identification by enzyme immunoassay of escape mutants S143L and G145R of hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus)]
Mutation
133 35314401 In vitro investigation of HBV clinical isolates from Chinese patients reveals that genotype C isolates possess higher infectivity than genotype B isolates
Mutation
134 35361141 Molecular characterization of hepatitis B virus (HBV) isolated from a pediatric case of acute lymphoid leukemia, with a delayed response to antiviral treatment: a case report
Mutation
135 35487093 Novel hepatitis B virus reverse transcriptase mutations in patients with sustained viremia despite long-term tenofovir treatment
Mutation
136 35657116 Effect of mutations across reverse transcriptase region on HBV replication and progression of liver diseases in Chinese patients
Mutation
137 35715541 Analysis of hepatic fibrosis markers in the serum of chronic hepatitis B patients according to basal core promoter/precore mutants
Mutation
138 35762289 Hepatitis B virus X gene impacts on the innate immunity and immune-tolerant phase in chronic hepatitis B virus infection
Mutation
139 36325017 Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progression
Mutation
140 36337771 Molecular detection of hepatitis B virus genotype E with immune escape mutations in chronic hepatitis B patients on long-term antiviral therapy in Jos, Nigeria
Mutation
141 36427857 Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D HBeAg-positive chronic hepatitis B
Mutation
142 36697207 Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection
Mutation
143 36766478 First Molecular Characterization of Chronic Hepatitis B Carriers in Timbuktu, Mali
Mutation
144 36849052 Resistant mutations within the hepatitis B virus reverse transcriptase sequence in treatment failure patients with chronic HBV infection in Vietnam
Mutation
145 36927420 Safety, tolerability, pharmacokinetics, and antiviral activity of the novel core protein allosteric modulator ZM-H1505R (Canocapavir) in chronic hepatitis B patients: a randomized multiple-dose escalation trial
Mutation
146 36970691 Global prevalence and molecular characteristics of three clades within hepatitis B virus subgenotype C2: Predominance of the C2(3) clade in South Korea
Mutation
147 37385475 Viral sequence analysis of chronic hepatitis B patients treated with the capsid assembly modulator JNJ-56136379 in the JADE phase 2a study
Mutation
148 37444453 Predicting Hepatocellular Carcinoma Risk in Chronic Hepatitis B Patients Receiving Finite Periods of Antiviral Therapy
Mutation
149 37813888 Genetic diversity of hepatitis B virus quasispecies in different biological compartments reveals distinct genotypes
Mutation
150 38140580 Core Promoter and Pre-Core Variants of the Hepatitis B Virus (HBV) Are Frequent in Chronic Hepatitis B HBeAg-Negative Patients Infected by Genotypes A and D
Mutation
151 38415521 Distribution and Clinical Significance of Hepatitis B virus A1762T/G1764A Double Mutation in Chronic Hepatitis B Patients: A Cross-Sectional Study
Mutation
152 38517681 Switching from combination therapy with entecavir hydrate plus tenofovir alafenamide fumarate to tenofovir alafenamide fumarate monotherapy in patients with chronic hepatitis B based on nucleotide sequences of hepatitis B virus pregenome RNA
Mutation
153 39297586 Interrelationships among MTHFR gene polymorphisms, MTRR gene polymorphisms, and HBV gene BCP 1762/1764 mutations with disease progression in Chronic hepatitis B virus infection patients
Mutation
154 39499325 Host and Viral Factors Influencing Chronic Hepatitis B Infection Across Three Generations in a Family
Mutation
155 39500510 Evolution of hepatitis B virus polymerase and surface genes in patients receiving finite antiviral therapy
Mutation
156 39528567 Evaluation of genotype characteristics and drug resistance mutations in patients with chronic hepatitis B
Mutation
157 39801782 Virological Response to Lamivudine and Tenofovir Treatment in a Mono-infected Chronic Hepatitis B Patient with Potential Tenofovir Resistance: A Case Report
Mutation
158 16637866 Hepatitis B virus genotypes and G1896A precore mutation in 486 Spanish patients with acute and chronic HBV infection
Mutation
159 30505167 Hepatitis B virus precore G1896A mutation in chronic liver disease patients with HBeAg negative serology from North India
Mutation
160 10535488 Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen
Mutation
161 11002246 Hepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinoma
Mutation
162 14756274 Efficacy of combined lamivudine and adefovir dipivoxil treatment for severe HBV graft reinfection after living donor liver transplantation
Mutation
163 16080797 HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers
Mutation
164 17888035 Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma
Mutation
165 21461076 Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection
Mutation
166 21490166 Impact of hepatitis B virus (HBV) x gene mutations on hepatocellular carcinoma development in chronic HBV infection
Mutation
167 21933446 Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B
Mutation
168 22882650 Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients
Mutation
169 23383661 Synergistic effects of A1896, T1653 and T1762/A1764 mutations in genotype c2 hepatitis B virus on development of hepatocellular carcinoma
Mutation
170 32568442 The genetic polymorphism down-regulating HLA-DRB1 enhancer activity facilitates HBV persistence, evolution and hepatocarcinogenesis in the Chinese Han population
Mutation
171 34899733 The Impact of HBV Quasispecies Features on Immune Status in HBsAg+/HBsAb+ Patients With HBV Genotype C Using Next-Generation Sequencing
Mutation
172 37735836 CHB patients with rtA181T-mutated HBV infection are associated with higher risk hepatocellular carcinoma due to increases in mutation rates of tumour suppressor genes
Mutation
173 12436473 Hepatitis B virus S gene mutants in a patient with chronic active hepatitis with circulating Anti-HBs antibodies
Mutation
174 17030194 Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient
Mutation
175 22342116 Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy
Mutation
176 26577140 Hepatitis B virus basal core promoter/precore mutants and association with liver cirrhosis in children with chronic hepatitis B virus infection
Mutation
177 34920100 Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients
Mutation
178 16618410 High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases
Mutation
179 17203204 Genotype and variations in core promoter and pre-core regions are related to progression of disease in HBV-infected patients from Northern Vietnam
Mutation
180 18551606 Hepatitis B virus X mutations occurring naturally associated with clinical severity of liver disease among Korean patients with chronic genotype C infection
Mutation
181 29285238 Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients
Mutation
182 31565220 Association between host TNF-alpha, TGF-beta1, p53 polymorphisms, HBV X gene mutation, HBV viral load and the progression of HBV-associated chronic liver disease in Indonesian patients
Mutation
183 35415256 Precore/core mutations of hepatitis B virus genotype D arising in different states of infection
Mutation
184 18844615 HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study
Mutation
185 20959817 Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma
Mutation
186 22919746 [Hepatitis B virus (HBV) mutation in enhancer I (HBV Enh I)/X-promoter and the relationship between chronic HBV-related disease spectrum]
Mutation
187 23272650 Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment
Mutation
188 24637457 Mutation profiling of the hepatitis B virus strains circulating in North Indian population
Mutation
189 30043328 Clinical implication and viral mutation in basal core promoter/pre-core of hepatitis B virus C/D recombinant
Mutation
190 31341154 Association Between HBx Variations and Development of Severe Liver Disease Among Indonesian Patients
Mutation
191 32523313 Conservation and variability of hepatitis B core at different chronic hepatitis stages
Mutation
192 33296295 Specific determination of hepatitis B e antigen by antibodies targeting precore unique epitope facilitates clinical diagnosis and drug evaluation against hepatitis B virus infection
Mutation
193 34029727 Increased hepatitis B virus quasispecies diversity is correlated with liver fibrosis progression
Mutation
194 35880842 The effects of the interactions of STAT4 rs7574865 with HBV mutations on the risk of hepatocellular carcinoma
Mutation
195 38037048 HLA-DR genetic polymorphisms and hepatitis B virus mutations affect the risk of hepatocellular carcinoma in Han Chinese population
Mutation
196 31846615 The genetic variability of hepatitis B virus subgenotype F1b precore/core gene is related to the outcome of the acute infection
Mutation
197 20675695 Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: a study of a large blood donor population
Mutation
198 27031988 Functional analysis of 'a' determinant mutations associated with occult HBV in HIV-positive South Africans
Mutation
199 28971485 Evolution of the serologic and virologic course of occult HBV infection in therapy experienced HIV co-infected patients
Mutation
200 28088502 The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological response
Mutation
201 12368144 [Evaluation of a quantitative HBV-DNA PCR assay in lamivudine treated hepatitis B-infected patients]
Mutation
202 20080060 Features and clinical implications of hepatitis B virus genotypes and mutations in basal core promoter/precore region in 507 Chinese patients with acute and chronic hepatitis B
Mutation
203 22720023 Hepatitis B virus gene mutations in liver diseases: a report from New Delhi
Mutation
204 24021712 Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions
Mutation
205 23852705 A complete genomic analysis of hepatitis B virus isolated from 516 Chinese patients with different clinical manifestations
Mutation
206 23871771 Positive selection signals of hepatitis B virus and their association with disease stages and viral genotypes
Mutation
207 27328656 Intergenotype recombinant analysis of full-length hepatitis B virus genomes from 516 Chinese patients with different illness categories
Mutation
208 20070500 Hepatitis B virus genotype and basal core promoter/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis
Mutation
209 20848146 Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure
Mutation
210 21739444 Hepatitis B virus genotype B with G1896A and A1762T/G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure
Mutation
211 26202756 Hepatitis B virus genotype B and mutations in basal core promoter and pre-core/core genes associated with acute-on-chronic liver failure: a multicenter cross-sectional study in China
Mutation
212 9011456 Pathogenesis of chronic liver disease in patients with chronic hepatitis B virus infection without serum HBeAg
Mutation
213 9593029 Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment
Mutation
214 9728561 Emergence of an S gene mutant during thymosin alpha1 therapy in a patient with chronic hepatitis B
Mutation
215 9862871 Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance
Mutation
216 10365797 Absence of mutations in the YMDD motif/B region of the hepatitis B virus polymerase in famciclovir therapy failure
Mutation
217 10502255 Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B
Mutation
218 10514111 Diversity of core promoter mutations in immune clearance phase of chronic HBV infection
Mutation
219 10589947 Famciclovir treatment of chronic hepatitis B in heart transplant recipients: a prospective trial
Mutation
220 10607231 Hepatitis B envelope protein mutants in human hepatocellular carcinoma tissues
Mutation
221 10655370 Line probe assay for monitoring drug resistance in hepatitis B virus-infected patients during antiviral therapy
Mutation
222 10762559 Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B
Mutation
223 10996115 In vivo dynamics and pathogenicity of wild-type and resistant Hepatitis B virus during long-term lamivudine monotherapy - a clinical note
Mutation
224 11020004 Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance
Mutation
225 11050059 Early detection of viral resistance by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B
Mutation
226 11124839 A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group
Mutation
227 11472634 Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers
Mutation
228 11480792 Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B
Mutation
229 11502520 In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil
Mutation
230 11584376 Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy
Mutation
231 11792996 Efficacy of famciclovir in the treatment of lamivudine resistance related to an atypical hepatitis B virus mutant
Mutation
232 11907436 Seroconversion after the addition of famciclovir therapy in a child with hepatitis B virus infection after liver transplantation who developed lamivudine resistance
Mutation
233 11938042 Lamivudine therapy of chronic hepatitis B in three groups of patients: non transplanted patients, liver recipients, and kidney recipients
Mutation
234 11993512 Hepatitis B genotypes and precore/basal core promoter mutants in HBeAg-negative chronic hepatitis B
Mutation
235 12010505 Sequential analysis of hepatitis B virus core promoter and precore regions in cancer survivor patients with chronic hepatitis B before, during and after interferon treatment
Mutation
236 12033768 In vivo suppression of precore mRNA synthesis is associated with mutations in the hepatitis B virus core promoter
Mutation
237 12135788 'Hbe minus' mutants of hepatitis B virus. Molecular characterization and its relation to viral genotypes
Mutation
238 12445424 Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy
Mutation
239 12500185 Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro
Mutation
240 12657823 [Natural YMDD motif mutations of HBV polymerase in the chronic hepatitis B virus infected patients]
Mutation
241 12727536 Lamivudine and Famciclovir resistant hepatitis B virus associated with fatal hepatic failure
Mutation
242 12759956 [Dynamic changes of basal core promoter and pre-core mutants of hepatitis B virus in patients with chronic hepatitis B virus infection]
Mutation
243 12794713 Molecular epidemiology and transmission of hepatitis B virus in close family contacts of HBV-related chronic liver disease patients
Mutation
244 12823594 Analysis of clinical, biochemical and viral factors associated with early relapse after lamivudine treatment for hepatitis B e antigen-negative chronic hepatitis B patients in Taiwan
Mutation
245 12829991 Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B
Mutation
246 12891527 Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase
Mutation
247 12931030 Low HBeAg serum levels correlate with the presence of the double A1762T/G1764A core promoter mutation and a positive response to interferon in patients with chronic hepatitis B virus infection
Mutation
248 12974898 Identification of a novel pre-S2 mutation in a subgroup of chronic carriers with spontaneous clearance of hepatitis B virus surface antigen
Mutation
249 14654974 Early response to interferon alpha treatment and long-term clinical outcome in Japanese patients with chronic HBV genotype C infection
Mutation
250 14675262 Evolution of wild type and mutants of the YMDD motif of hepatitis B virus polymerase during lamivudine therapy
Mutation
251 14752824 Identification of HBV DNA sequences that are predictive of response to lamivudine therapy
Mutation
252 15078472 Sequential combination therapy of HBe antigen-negative/virus-DNA-positive chronic hepatitis B with famciclovir or lamivudine and interferon-alpha-2a
Mutation
253 15240859 Longitudinal study on mutation profiles of core promoter and precore regions of the hepatitis B virus genome in children
Mutation
254 15308745 Hepatitis B virus capsid assembly is enhanced by naturally occurring mutation F97L
Mutation
255 15308845 Detection of YMDD motif mutants by oligonucleotide chips in lamivudine-untreated patients with chronic hepatitis B virus infection
Mutation
256 15311721 Efficacy of alpha interferon therapy for lamivudine resistance in chronic hepatitis B
Mutation
257 15338371 Prognostic indicators of breakthrough hepatitis during lamivudine monotherapy for chronic hepatitis B virus infection
Mutation
258 15340520 [A study on detection method of lamivudine related mutations in hepatitis B virus polymerase gene]
Mutation
259 15544736 [Determination of hepatitis B virus genotype and detection of lamivudine-resistance mutations]
Mutation
260 15572007 The precore mutation is associated with severity of liver damage in Brazilian patients with chronic hepatitis B
Mutation
261 15618847 Long-term therapy with lamivudine in renal transplant recipients with chronic hepatitis B
Mutation
262 15634980 Development of a molecular-beacon assay to detect the G1896A precore mutation in hepatitis B virus-infected individuals
Mutation
263 15648063 Clinical and virological characteristics of lamivudine resistance in chronic hepatitis B patients: a single center experience
Mutation
264 15655050 Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients
Mutation
265 15664258 Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure
Mutation
266 15720530 Long-term follow-up of chronic hepatitis B after the emergence of mutations in the hepatitis B virus polymerase region
Mutation
267 15720534 Three-phase sequential combined treatment with lamivudine and interferon in young patients with chronic hepatitis B
Mutation
268 15834874 Nucleotide mutations associated with hepatitis B e antigen negativity
Mutation
269 15893561 A novel accurate amplification created restriction site method for determination of the wild type and the precore mutant hepatitis B virus variants
Mutation
270 15932365 Changes in different regions of hepatitis B virus gene in hepatitis B 'e' antigen-negative patients with chronic hepatitis B: the effect of long-term lamivudine therapy
Mutation
271 15953865 Overlapping gene mutations of hepatitis B virus in a chronic hepatitis B patient with hepatitis B surface antigen loss during lamivudine therapy
Mutation
272 15973769 Character of HBV (hepatitis B virus) polymerase gene rtM204V/I and rtL180M mutation in patients with lamivudine resistance
Mutation
273 15977237 Complete genome sequence and phylogenetic analysis of hepatitis B virus isolated from Turkish patients with chronic HBV infection
Mutation
274 15985011 Response to long-term lamivudine treatment (up to 5 years) in patients with severe chronic hepatitis B, role of genotype and drug resistance
Mutation
275 16004082 Inhibition of hepatitis B virus gene expression and replication by helioxanthin and its derivative
Mutation
276 16099903 T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D
Mutation
277 16108169 Chronic hepatitis B--treatment with nucleoside analogues
Mutation
278 16197491 Clinical reactivation during lamivudine treatment correlates with mutations in the precore/core promoter and polymerase regions of hepatitis B virus in patients with anti-hepatitis B e-positive chronic hepatitis
Mutation
279 16220028 Hepatitis B virus DNA quantitation and detection of core promoter, precore and polymerase mutations in chronic hepatitis B: evaluation and clinical usefulness of three new commercial assays
Mutation
280 16227269 Reduced secretion of virions and hepatitis B virus (HBV) surface antigen of a naturally occurring HBV variant correlates with the accumulation of the small S envelope protein in the endoplasmic reticulum and Golgi apparatus
Mutation
281 16358376 Clinical features of chronic hepatitis B patients with YMDD mutation after lamivudine therapy
Mutation
282 16428891 Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India
Mutation
283 16448607 [Lamivudine and adefovir resistance in a patient with HBeAg negative chronic hepatitis B]
Mutation
284 16461777 Resistance to adefovir dipivoxil in lamivudine resistant chronic hepatitis B patients treated with adefovir dipivoxil
Mutation
285 16618409 Predominance of hepatitis B virus YMDD mutants is prognostic of viral DNA breakthrough
Mutation
286 16637865 Association of core promoter/precore mutations and viral load in e antigen-negative chronic hepatitis B patients
Mutation
287 16729316 Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy
Mutation
288 16757589 Detection of rtN236T and rtA181V/T mutations associated with resistance to adefovir dipivoxil in samples from patients with chronic hepatitis B virus infection by the INNO-LiPA HBV DR line probe assay (version 2)
Mutation
289 16757620 Unusual naturally occurring humoral and cellular mutated epitopes of hepatitis B virus in a chronically infected argentine patient with anti-HBs antibodies
Mutation
290 16789011 Changes in viral loads of lamivudine-resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy
Mutation
291 16789012 Basal core promoter, precore region mutations of HBV and their association with e antigen, genotype, and severity of liver disease in patients with chronic hepatitis B in India
Mutation
292 16830379 Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs
Mutation
293 16847965 Identification of hepatitis B virus subgenotype A3 in rural Gabon
Mutation
294 16856618 The clinical impact of early detection of the YMDD mutant on the outcomes of long-term lamivudine therapy in patients with chronic hepatitis B
Mutation
295 16871563 Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy
Mutation
296 16928212 Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy
Mutation
297 16963200 A unique amino acid substitution, T126I, in human genotype C of hepatitis B virus S gene and its possible influence on antigenic structural change
Mutation
298 16982790 Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif
Mutation
299 17178796 Two-year assessment of entecavir resistance in Lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present
Mutation
300 17187404 Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein
Mutation
301 17239478 Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient
Mutation
302 17258721 Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance
Mutation
303 17302381 Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases
Mutation
304 17317127 Dynamic changes of hepatitis B virus polymerase gene including YMDD motif in lamivudine-treated patients with chronic hepatitis B
Mutation
305 17400303 Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B
Mutation
306 17438047 The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro
Mutation
307 17498248 Analysis of the core gene of hepatitis B virus in Korean patients
Mutation
308 17627632 Impact of viral genotypes and naturally occurring mutations on biological properties of hepatitis B virus
Mutation
309 17652045 Sequential treatment with lamivudine and alpha-interferon in anti-HBe-positive chronic hepatitis B patients: a pilot study
Mutation
310 17697019 Association between lamivudine sensitivity and the number of substitutions in the reverse transcriptase region of the hepatitis B virus polymerase
Mutation
311 17713159 A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment
Mutation
312 17825452 Five subgenotypes of hepatitis B virus genotype B with distinct geographic and virological characteristics
Mutation
313 17854034 Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: analyses of the polymerase gene and full-length sequences
Mutation
314 17913933 Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay
Mutation
315 17934636 Hepatitis B virus genotype E detected in Brazil in an African patient who is a frequent traveler
Mutation
316 17971947 [Efficacy of adefovir dipivoxil was not related to genotypes B and C of hepatitis B virus: a randomized, double-blind, multicenter clinical study]
Mutation
317 17988612 [Adefovir dipivoxil compassionate use program in Spain: efficacy and resistance analysis]
Mutation
318 18036104 Efficacy of hepatitis B virus (HBV) vaccination in treating lamivudine-resistant HBV reactivation following hepatitis B surface antigen seroconversion
Mutation
319 18036224 Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates
Mutation
320 18070286 Hepatitis B virus polymerase variants associated with entecavir drug resistance in treatment-naive patients
Mutation
321 18171343 Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case
Mutation
322 18211717 Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil
Mutation
323 18265656 Clinical significance of basal core promoter and precore mutations in chronic hepatitis B
Mutation
324 18266648 A complete genomic analysis of hepatitis B virus genotypes and mutations in HBeAg-negative chronic hepatitis B in China
Mutation
325 18329126 Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B
Mutation
326 18433023 Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B
Mutation
327 18433925 Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up
Mutation
328 18537180 The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound
Mutation
329 18571815 Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance
Mutation
330 18606836 Rolling circle amplification, a powerful tool for genetic and functional studies of complete hepatitis B virus genomes from low-level infections and for directly probing covalently closed circular DNA
Mutation
331 18752330 Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
Mutation
332 18814242 Clinical significance of a set of single nucleotide polymorphisms of hepatitis B virus core gene in Chinese Han patients with chronic hepatitis B
Mutation
333 18822888 [YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy]
Mutation
334 19065672 Complex dynamics of hepatitis B virus resistance to adefovir
Mutation
335 19070921 The association of HBV core promoter double mutations (A1762T and G1764A) with viral load differs between HBeAg positive and anti-HBe positive individuals: a longitudinal analysis
Mutation
336 19107976 Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study
Mutation
337 19125938 Spontaneous HBeAg seroconversion and loss of hepatitis B virus DNA after acute flare due to development of drug resistant mutants during entecavir monotherapy
Mutation
338 19152408 Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir
Mutation
339 19152409 Association of lamivudine-resistant mutational patterns with the antiviral effect of adefovir in patients with chronic hepatitis B
Mutation
340 19195324 Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response
Mutation
341 19222103 Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients
Mutation
342 19231002 Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy
Mutation
343 19280622 Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naive patients is rare through 5 years of therapy
Mutation
344 19319958 Prevalence of basal core promoter and precore mutations in Chinese chronic hepatitis B patients and correlation with serum HBeAG titers
Mutation
345 19323782 Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy
Mutation
346 19430095 Association of baseline viral factors with response to lamivudine therapy in chronic hepatitis B patients with high serum alanine aminotransferase levels
Mutation
347 19439550 Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene
Mutation
348 19442845 A sensitive direct sequencing assay based on nested PCR for the detection of HBV polymerase and surface glycoprotein mutations
Mutation
349 19566788 Naturally occurring amino-acid substitutions to nucleos(t)ide analogues in treatment naive Turkish patients with chronic hepatitis B
Mutation
350 19578241 Adefovir dipivoxil resistance patterns in patients with lamivudine-resistant chronic hepatitis B
Mutation
351 19578244 Clinical and virological responses to clevudine therapy in chronic hepatitis B patients: results at 1 year of an open-labelled prospective study
Mutation
352 19651117 Detection of the rtA181V/T and rtN236T mutations associated with resistance to adefovir dipivoxil using a ligase detection reaction assay
Mutation
353 19785624 Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naive patients with chronic hepatitis B
Mutation
354 19811086 Downregulation of HLA class II molecules by G1896A pre-core mutation in chronic hepatitis B virus infection
Mutation
355 19933798 Mechanism of entecavir resistance of hepatitis B virus with viral breakthrough as determined by long-term clinical assessment and molecular docking simulation
Mutation
356 20007398 Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy
Mutation
357 20119580 Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations
Mutation
358 20164224 Identification and characterization of clevudine-resistant mutants of hepatitis B virus isolated from chronic hepatitis B patients
Mutation
359 20332649 Response to adefovir depends on mutation patterns in precore region, basal core promoter and reverse transcriptase, and on-treatment responses in Lamivudine-resistant chronic hepatitis B patients
Mutation
360 20382061 Monitoring of hepatitis B virus surface antigen escape mutations and concomitantly nucleos(t)ide analog resistance mutations in Turkish patients with chronic hepatitis B
Mutation
361 20970466 Characterization of hepatitis virus B isolated from a multi-drug refractory patient
Mutation
362 21056552 Variable influence of mutational patterns in reverse-transcriptase domain on replication capacity of hepatitis B virus isolates from antiviral-experienced patients
Mutation
363 21149924 Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients
Mutation
364 21168854 Human interleukin-10 genotypes are associated with different precore/core gene mutation patterns in children with chronic hepatitis B virus infection
Mutation
365 21177673 Detection of hepatitis B virus genotype A3 and primary drug resistance mutations in African immigrants with chronic hepatitis B in Spain
Mutation
366 21181915 Presence of valine at position 27 of the hepatitis B virus core gene is associated with severe liver inflammation in Chinese patients
Mutation
367 21181918 Molecular epidemiology of chronic hepatitis B virus infection in Greece
Mutation
368 21264860 Gender disparity in distribution of the major hydrophilic region variants of hepatitis B virus genotype C according to hepatitis B e antigen serostatus
Mutation
369 21311107 HBV core region variability: effect of antiviral treatments on main epitopic regions
Mutation
370 21392168 Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection
Mutation
371 21396961 HBV DNA replication mediated by cloned patient HBV reverse transcriptase genes from HBV genotypes A-H and its use in antiviral phenotyping assays
Mutation
372 21442057 Predictors for early HBeAg loss during lamivudine therapy in HBeAg-positive chronic hepatitis B patients with acute exacerbation
Mutation
373 21468263 Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children
Mutation
374 21484144 A comparison of 48-week treatment efficacy between clevudine and entecavir in treatment-naive patients with chronic hepatitis B
Mutation
375 21484148 Extended treatment with lamivudine and adefovir dipivoxil in chronic hepatitis B patients with lamivudine resistance
Mutation
376 21503906 Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients
Mutation
377 21503942 Emergence of hepatitis B virus S gene mutants in patients experiencing hepatitis B surface antigen seroconversion after peginterferon therapy
Mutation
378 21513743 Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array
Mutation
379 21569538 A336C/A336T/T337C variations in HBV core gene and spontaneous hepatitis B e antigen loss in chronic hepatitis B patients
Mutation
380 21601012 Molecular characterization and phylogenetic analysis of full-genome HBV subgenotype D3 sequences from Serbia
Mutation
381 21640384 Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers
Mutation
382 21692935 Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B
Mutation
383 21696601 Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations
Mutation
384 21734806 Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients
Mutation
385 21742757 Ultra-deep pyrosequencing analysis of the hepatitis B virus preCore region and main catalytic motif of the viral polymerase in the same viral genome
Mutation
386 21777282 rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy
Mutation
387 21784687 Antiviral drug-associated potential vaccine-escape hepatitis B virus mutants in Turkish patients with chronic hepatitis B
Mutation
388 21785721 Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years
Mutation
389 21789847 [Variants and quasispecies of reverse transcriptase region in polymerase gene of hepatitis B virus during lamivudine treatment]
Mutation
390 21814558 The G1613A mutation in the HBV genome affects HBeAg expression and viral replication through altered core promoter activity
Mutation
391 21816062 Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment
Mutation
392 21883736 Four-year follow-up of two chronic hepatitis B recipients of hepatitis B surface antigen-positive cadaveric liver grafts from asymptomatic carriers
Mutation
393 21911882 Evolution of hepatitis B virus during long-term therapy in patients with chronic hepatitis B
Mutation
394 21959623 Molecular epidemical characteristics of Lamivudine resistance mutations of HBV in southern China
Mutation
395 22007495 [Effect of Lamivudine on chronic hepatitis B patients with chemotherapy or immunosuppressive agents therapy and research the drug resistance]
Mutation
396 22052677 Phenotypic assay of a hepatitis B virus strain carrying an rtS246T variant using a new strategy
Mutation
397 22087110 A study of genotypes, mutants and nucleotide sequence of hepatitis B virus in Pakistan: HBV genotypes in pakistan
Mutation
398 22097972 Five years of treatment with adefovir dipivoxil in Chinese patients with HBeAg-positive chronic hepatitis B
Mutation
399 22098177 The influence of YMDD mutation patterns on clinical outcomes in patients with adefovir add-on lamivudine combination treatment
Mutation
400 22138714 Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B
Mutation
401 22170539 Discrepancy of potential antiviral resistance mutation profiles within the HBV reverse transcriptase between nucleos(t)ide analogue-untreated and -treated patients with chronic hepatitis B in a hospital in China
Mutation
402 22170540 Pre-existing YMDD mutants in treatment-naive patients with chronic hepatitis B are not selected during lamivudine therapy
Mutation
403 22224083 Frequency and mutation patterns of resistance in patients with chronic hepatitis B infection treated with nucleos(t)ide analogs in add-on and switch strategies
Mutation
404 22246826 Characterization of hepatitis B virus genome variability in Iranian patients with chronic infection, a nationwide study
Mutation
405 22260834 Risk factors of gene-resistant mutations in different nucleosides
Mutation
406 22312387 Multidrug-resistant hepatitis B virus strain in a chronic Turkish patient
Mutation
407 22312396 Prevalence and clinical significance of hepatitis B Basal core promoter and precore gene mutations in southern Iranian patients
Mutation
408 22338219 [The mutation patterns of HBV P gene and genotyping in patients with lanivudine-resistant chronic hepatitis B]
Mutation
409 22340383 Characterization of hepatitis B virus genotypes/subgenotypes in 1,301 patients with chronic hepatitis B in North China
Mutation
410 22398037 The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation
Mutation
411 22442974 [Heterogeneity of hepatitis B virus and diagnostic potential of modern test systems for the detection of HBsAg]
Mutation
412 22453135 Long-term monitoring drug resistance by ultra-deep pyrosequencing in a chronic hepatitis B virus (HBV)-infected patient exposed to several unsuccessful therapy schemes
Mutation
413 22510826 Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes
Mutation
414 22523569 Dynamics of hepatitis B virus quasispecies in association with nucleos(t)ide analogue treatment determined by ultra-deep sequencing
Mutation
415 22579480 HBV genotypes prevalence, precore and basal core mutants in Morocco
Mutation
416 22585719 Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance
Mutation
417 22592516 HIV and Hepatitis B coinfection among perinatally HIV-infected Thai adolescents
Mutation
418 22666402 Ultra-deep pyrosequencing detects conserved genomic sites and quantifies linkage of drug-resistant amino acid changes in the hepatitis B virus genome
Mutation
419 22686039 [Analysis of the complete hepatitis B virus genomes in a patient for repeated seroconversion to anti-HBe antibody due to co-infection with two virus clones]
Mutation
420 22728692 Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir
Mutation
421 22729192 YMDD motif mutations in chronic hepatitis B antiviral treatment naive patients: a multi-center study
Mutation
422 22767306 Evaluation of a "home-made" method to determine viral genotype and characterize mutations conferring drug resistance in chronic hepatitis B patients
Mutation
423 22941290 High prevalence of the B2+C2 subgenotype mixture in patients with chronic hepatitis B in Eastern China
Mutation
424 22960603 Hepatitis B virus basal core promoter mutations A1762T/G1764A are associated with genotype C and a low serum HBsAg level in chronically-infected HBeAg-positive Chinese patients
Mutation
425 22997074 Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B
Mutation
426 23023992 Do different lamivudine-resistant hepatitis B genotypes carry the same risk of entecavir resistance?
Mutation
427 23026293 Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy
Mutation
428 23112104 Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion
Mutation
429 23113154 Identification of Hepatitis B Virus Surface Antigen (HBsAg) Genotypes and Variations in Chronic Carriers from Isfahan Province, Iran
Mutation
430 23146520 Hepatitis B reactivation in a renal transplant patient due to a surface antigen mutant strain: a case report
Mutation
431 23180290 A case of hepatitis B reactivation due to the hepatitis B virus escape mutant in a patient undergoing chemotherapy
Mutation
432 23197889 Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment
Mutation
433 23322992 Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B
Mutation
434 23355917 Efficacy of 3 years of adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance
Mutation
435 23423477 Impact of rtI233V mutation in hepatitis B virus polymerase protein and adefovir efficacy: Homology modeling and molecular docking studies
Mutation
436 23458523 Efficacy and safety of telbivudine plus adefovir dipivoxil combination therapy and entecavir monotherapy for HBeAg-positive chronic hepatitis B patients with resistance to adefovir dipivoxil
Mutation
437 23485939 Virological response and antiviral resistance mutations in chronic hepatitis B subjects experiencing entecavir therapy: an Indian subcontinent perspective
Mutation
438 23596461 Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients
Mutation
439 23599717 Correlation between viral load of HBV in chronic hepatitis B patients and precore and Basal core promoter mutations
Mutation
440 23627028 [Mutation analysis of the HBV reverse transcriptase in nucleos(t)ide-treated patients with chronic HBV infection]
Mutation
441 23678186 The L60V variation in hepatitis B virus core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication
Mutation
442 23710315 Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B
Mutation
443 23805155 Virological Response and Muscular Adverse Events during Long-Term Clevudine Therapy in Chronic Hepatitis B Patients
Mutation
444 23918533 Hepatitis B virus reverse transcriptase mutations in treatment Naive chronic hepatitis B patients
Mutation
445 23968804 Dynamics of hepatitis B virus resistance substitutions correlates with virological response in lamivudine-refractory patients with entecavir rescue monotherapy
Mutation
446 23971933 [HBV vaccine escape mutations in a chronic hepatitis B patient treated with nucleos(t)ide analogues]
Mutation
447 24006435 HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations
Mutation
448 24009186 Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines
Mutation
449 24064642 Mutation analysis of hepatitis B virus reverse transcriptase region among untreated chronically infected patients in Ahvaz city (South-West of Iran)
Mutation
450 24160943 Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B
Mutation
451 24175847 Prevelance of common YMDD motif mutations in long term treated chronic HBV infections in a Turkish population
Mutation
452 24187552 The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation
Mutation
453 24316031 Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naive and lamivudine-treated patients with chronic hepatitis B
Mutation
454 24348637 Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance
Mutation
455 24368224 Randomized comparison of tenofovir disoproxil fumarate vs emtricitabine and tenofovir disoproxil fumarate in patients with lamivudine-resistant chronic hepatitis B
Mutation
456 24399391 Antiviral efficacy of adefovir dipivoxil in the treatment of chronic hepatitis B subjects from Indian subcontinent
Mutation
457 24406435 Clinical significance of hepatitis B virus precore and core promoter variants in Korean patients with chronic hepatitis B
Mutation
458 24497877 Drug-resistance associated mutations in polymerase (p) gene of hepatitis B virus isolated from malaysian HBV carriers
Mutation
459 24589944 Lamivudine and Adefovir Motif Variants Detected in chronic Hepatitis B patients
Mutation
460 24630522 Analysis of potential antiviral resistance mutation profiles within the HBV reverse transcriptase in untreated chronic hepatitis B patients using an ultra-deep pyrosequencing method
Mutation
461 24696492 The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene
Mutation
462 24790911 Analysis of reverse transcriptase gene mutations in the hepatitis B virus at a university hospital in Korea
Mutation
463 24835494 Molecular epidemiology and genotyping of hepatitis B virus of HBsAg-positive patients in Oman
Mutation
464 24836314 Viral evolutionary changes during tenofovir treatment in a chronic hepatitis B patient with sequential nucleos(t)ide therapy
Mutation
465 37968095 Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss
Integration
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.