Overview of HSV1 associated Herpes simplex (Mutation)

ID Literature Title Group
1 15456088 Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients
Mutation
2 15040541 Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child
Mutation
3 30176164 HSV-1 DNA polymerase 3'-5' exonuclease-deficient mutant D368A exhibits severely reduced viral DNA synthesis and polymerase expression
Mutation
4 33588012 Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases
Mutation
5 9727026 Impaired mismatch extension by a herpes simplex DNA polymerase mutant with an editing nuclease defect
Mutation
6 17713155 DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions
Mutation
7 36059135 Heterogeneity and viral replication fitness of HSV-1 clinical isolates with mutations in the thymidine kinase and DNA polymerase
Mutation
8 37224525 A Herpes Simplex Virus 1 DNA Polymerase Multidrug Resistance Mutation Identified in a Patient With Immunodeficiency and Confirmed by Gene Editing
Mutation
9 9884409 The role of a single N-linked glycosylation site for a functional epitope of herpes simplex virus type 1 envelope glycoprotein gC
Mutation
10 24647818 Mutations in herpes simplex virus gD protein affect receptor binding by different molecular mechanisms
Mutation
11 2444718 Structural properties and reactivity of N-terminal synthetic peptides of herpes simplex virus type 1 glycoprotein D by using antipeptide antibodies and group VII monoclonal antibodies
Mutation
12 10729168 Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB)
Mutation
13 21980294 Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1
Mutation
14 35632611 Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication
Mutation
15 34419483 Antiviral susceptibility of recombinant Herpes simplex virus 1 strains with specific polymerase amino acid changes
Mutation
16 3033142 The herpes simplex virus type 1 DNA polymerase gene: site of phosphonoacetic acid resistance mutation in strain Angelotti is highly conserved
Mutation
17 16781887 Pathogenicity and response to topical antiviral therapy in a murine model of acyclovir-sensitive and acyclovir-resistant herpes simplex viruses isolated from the same patient
Mutation
18 28576448 Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays
Mutation
19 37632051 Variant Analysis of the Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus in Korea: Frequency of Acyclovir Resistance Mutations
Mutation
20 8021603 Analysis of the thymidine kinase of a herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2'-deoxyuridine
Mutation
21 16970995 Resistance of herpes simplex virus type 1 to acyclovir: thymidine kinase gene mutagenesis study
Mutation
22 22796575 Effects of mutations on herpes simplex virus 1 thymidine kinase functionality: an in vitro assay based on detection of monophosphate forms of acyclovir and thymidine using HPLC/DAD
Mutation
23 22906425 Significance of amino acid substitutions in the thymidine kinase gene of herpes simplex virus type 1 for resistance
Mutation
24 23041200 Impact of novel mutations of herpes simplex virus 1 and 2 thymidine kinases on acyclovir phosphorylation activity
Mutation
25 31152759 UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated from hematology department patients
Mutation
26 20071482 Differential importance of highly conserved residues in UL24 for herpes simplex virus 1 replication in vivo and reactivation
Mutation
27 18299638 A single drug-resistance mutation in HSV-1 UL52 primase points to a difference between two helicase-primase inhibitors in their mode of interaction with the antiviral target
Mutation
28 18539344 Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity
Mutation
29 20420855 Effects of therapy using a helicase-primase inhibitor (HPI) in mice infected with deliberate mixtures of wild-type HSV-1 and an HPI-resistant UL5 mutant
Mutation
30 20453068 Mismatch primer-based PCR reveals that helicase-primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during incubation with the inhibitor
Mutation
31 17404685 Single amino acid substitutions in the HSV-1 helicase protein that confer resistance to the helicase-primase inhibitor BAY 57-1293 are associated with increased or decreased virus growth characteristics in tissue culture
Mutation
32 17550887 Detection of HSV-1 variants highly resistant to the helicase-primase inhibitor BAY 57-1293 at high frequency in 2 of 10 recent clinical isolates of HSV-1
Mutation
33 8847518 Thermosensitive UL9 gene function is required for early stages of herpes simplex virus type 1 DNA synthesis
Mutation
34 22144074 VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo
Mutation
35 25810545 Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 Is Regulated by Phosphorylation at a Specific Site
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.