Overview of IV associated Influenza A (Mutation)

ID Literature Title Group
1 34141489 Dynamic residue interaction network analysis of the oseltamivir binding site of N1 neuraminidase and its H274Y mutation site conferring drug resistance in influenza A virus
Mutation
2 32161172 An R195K Mutation in the PA-X Protein Increases the Virulence and Transmission of Influenza A Virus in Mammalian Hosts
Mutation
3 24576826 Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong
Mutation
4 32459617 Genetic diversity of influenza A viruses circulating in Bulgaria during the 2018-2019 winter season
Mutation
5 31719554 Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus
Mutation
6 31917822 The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
Mutation
7 34070388 Molecular Characterization of Seasonal Influenza A and B from Hospitalized Patients in Thailand in 2018-2019
Mutation
8 39459850 Evolutionary Insights from Association Rule Mining of Co-Occurring Mutations in Influenza Hemagglutinin and Neuraminidase
Mutation
9 24667168 Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses
Mutation
10 39443295 Evolution of Influenza A(H3N2) Viruses in Bhutan for Two Consecutive Years, 2022 and 2023
Mutation
11 24951824 The R292K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013 (H7N9) influenza virus in ferrets
Mutation
12 20702632 PB2 and hemagglutinin mutations are major determinants of host range and virulence in mouse-adapted influenza A virus
Mutation
13 24153120 Newly emerging mutations in the matrix genes of the human influenza A(H1N1)pdm09 and A(H3N2) viruses reduce the detection sensitivity of real-time reverse transcription-PCR
Mutation
14 25124927 Characterization of drug-resistant influenza A(H7N9) variants isolated from an oseltamivir-treated patient in Taiwan
Mutation
15 26071346 Quantitative analysis of influenza A (H3N2) E119V and R292K variants in clinical specimens by real-time reverse transcription polymerase chain reaction
Mutation
16 29278832 An epidemic surge of influenza A(H3N2) virus at the end of the 2016-2017 season in Taiwan with an increased viral genetic heterogeneity
Mutation
17 21364825 Identification of sequence mutations affecting hemagglutinin specificity to sialic acid receptor in influenza A virus subtypes
Mutation
18 30700609 The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses
Mutation
19 23019374 Virulence and transmissibility of H1N2 influenza virus in ferrets imply the continuing threat of triple-reassortant swine viruses
Mutation
20 33418392 A bivalent live attenuated influenza virus vaccine protects against H1N2 and H3N2 viral infection in swine
Mutation
21 23437766 Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus
Mutation
22 27630240 Human Monoclonal Antibody 81.39a Effectively Neutralizes Emerging Influenza A Viruses of Group 1 and 2 Hemagglutinins
Mutation
23 28252002 NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A Virus
Mutation
24 23436652 Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus
Mutation
25 16516984 Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants
Mutation
26 39557155 Virological and Clinical Outcomes of Influenza Outpatients Treated With Baloxavir, Oseltamivir, or Laninamivir in the 2023-2024 Season
Mutation
27 19889895 Rapid and specific detection of amantadine-resistant influenza A viruses with a Ser31Asn mutation by the cycling probe method
Mutation
28 27203354 Drug-Resistant and Genetic Evolutionary Analysis of Influenza Virus from Patients During the 2013 and 2014 Influenza Season in Beijing
Mutation
29 31223581 Genetic and Phylogenetic Characterization of the M Gene of Influenza A Virus Isolated from Iranian Patients
Mutation
30 21917953 Analysis of influenza virus hemagglutinin receptor binding mutants with limited receptor recognition properties and conditional replication characteristics
Mutation
31 28385598 Discovery of acylguanidine oseltamivir carboxylate derivatives as potent neuraminidase inhibitors
Mutation
32 25701593 Influenza A viruses of swine circulating in the United States during 2009-2014 are susceptible to neuraminidase inhibitors but show lineage-dependent resistance to adamantanes
Mutation
33 25740997 Neuraminidase Mutations Conferring Resistance to Oseltamivir in Influenza A(H7N9) Viruses
Mutation
34 35467364 Interactions between Influenza A Virus Nucleoprotein and Gene Segment Untranslated Regions Facilitate Selective Modulation of Viral Gene Expression
Mutation
35 20689744 The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase
Mutation
36 39459976 Insights into Genetic and Antigenic Characteristics of Influenza A(H1N1)pdm09 Viruses Circulating in Sicily During the Surveillance Season 2023-2024: The Potential Effect on the Seasonal Vaccine Effectiveness
Mutation
37 39248566 Vaccine-induced NA immunity decreases viral shedding, but does not disrupt chains of airborne transmission for the 2009 pandemic H1N1 virus in ferrets
Mutation
38 39839124 PB2 and PA mutations contribute to the pathogenicity of mouse-adapted pdmH1N1-Venus reporter influenza A virus in a mammalian model
Mutation
39 20130063 Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission
Mutation
40 21483816 Reassortment and mutations associated with emergence and spread of oseltamivir-resistant seasonal influenza A/H1N1 viruses in 2005-2009
Mutation
41 22438920 Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice
Mutation
42 23966381 Fecal influenza in mammals: selection of novel variants
Mutation
43 24522908 Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice
Mutation
44 25142579 Influenza A virus polymerase is a site for adaptive changes during experimental evolution in bat cells
Mutation
45 25210166 Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom
Mutation
46 26847414 Amino acid changes in PB2 and HA affect the growth of a recombinant influenza virus expressing a fluorescent reporter protein
Mutation
47 28860593 Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene
Mutation
48 26038501 Drug susceptibility profile and pathogenicity of H7N9 influenza virus (Anhui1 lineage) with R292K substitution
Mutation
49 30787926 Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model
Mutation
50 33142846 A Mutated PB1 Residue 319 Synergizes with the PB2 N265S Mutation of the Live Attenuated Influenza Vaccine to Convey Temperature Sensitivity
Mutation
51 27066703 Adaptive amino acid substitutions enhance the virulence of a novel human H7N9 influenza virus in mice
Mutation
52 33408229 Next-Generation Sequencing Analysis of the Within-Host Genetic Diversity of Influenza A(H1N1)pdm09 Viruses in the Upper and Lower Respiratory Tracts of Patients with Severe Influenza
Mutation
53 35044213 The Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts
Mutation
54 19934602 A Serine12Stop mutation in PB1-F2 of the 2009 pandemic (H1N1) influenza A: a possible reason for its enhanced transmission and pathogenicity to humans
Mutation
55 25100840 Influenza A virus acquires enhanced pathogenicity and transmissibility after serial passages in swine
Mutation
56 29783694 Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production
Mutation
57 30352857 The mechanism of resistance to favipiravir in influenza
Mutation
58 32721992 Differential Viral-Host Immune Interactions Associated with Oseltamivir-Resistant H275Y and Wild-Type H1N1 A(pdm09) Influenza Virus Pathogenicity
Mutation
59 27714494 Role of R292K mutation in influenza H7N9 neuraminidase toward oseltamivir susceptibility: MD and MM/PB(GB)SA study
Mutation
60 39339943 The Synergistic Effect of Baloxavir and Neuraminidase Inhibitors against Influenza Viruses In Vitro
Mutation
61 22090127 Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers
Mutation
62 22102733 Synergistic adaptive mutations in the hemagglutinin and polymerase acidic protein lead to increased virulence of pandemic 2009 H1N1 influenza A virus in mice
Mutation
63 28202753 Mutation of the Second Sialic Acid-Binding Site, Resulting in Reduced Neuraminidase Activity, Preceded the Emergence of H7N9 Influenza A Virus
Mutation
64 29563296 New Threats from H7N9 Influenza Virus: Spread and Evolution of High- and Low-Pathogenicity Variants with High Genomic Diversity in Wave Five
Mutation
65 29688498 Dynamic Variation and Reversion in the Signature Amino Acids of H7N9 Virus During Human Infection
Mutation
66 39212447 Two amino acid residues in the N-terminal region of the polymerase acidic protein determine the virulence of Eurasian avian-like H1N1 swine influenza viruses in mice
Mutation
67 18058063 The role of the N-terminal caspase cleavage site in the nucleoprotein of influenza A virus in vitro and in vivo
Mutation
68 19451021 Genetic microheterogeneity of emerging H275Y influenza virus A (H1N1) in Toronto, Ontario, Canada from the 2007-2008 respiratory season
Mutation
69 27664027 G45R on nonstructural protein 1 of influenza A virus contributes to virulence by increasing the expression of proinflammatory cytokines in mice
Mutation
70 29587786 Effects of the S42 residue of the H1N1 swine influenza virus NS1 protein on interferon responses and virus replication
Mutation
71 32093780 Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus
Mutation
72 33281788 Altering Intracellular Localization of the RNA Interference Factors by Influenza A Virus Non-structural Protein 1
Mutation
73 31044563 Alternative interaction sites in the influenza A virus nucleoprotein mediate viral escape from the importin-alpha7 mediated nuclear import pathway
Mutation
74 31267843 Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice
Mutation
75 20220153 Rapid detection of influenza A pandemic (H1N1) 2009 virus neuraminidase resistance mutation H275Y by real-time reverse transcriptase PCR
Mutation
76 20404128 Prophylactic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H274Y neuraminidase mutation
Mutation
77 20587176 Oseltamivir resistance in adult oncology and hematology patients infected with pandemic (H1N1) 2009 virus, Australia
Mutation
78 20951165 The validation of a real-time RT-PCR assay which detects influenza A and types simultaneously for influenza A H1N1 (2009) and oseltamivir-resistant (H275Y) influenza A H1N1 (2009)
Mutation
79 21062390 Early emergence of an H275Y mutation in a hematopoietic cell transplant recipient treated with intravenous peramivir
Mutation
80 21208927 Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets
Mutation
81 21731753 Rapid detection of the H275Y oseltamivir resistance mutation in influenza A/H1N1 2009 by single base pair RT-PCR and high-resolution melting
Mutation
82 21801626 Multidrug-resistant pandemic (H1N1) 2009 infection in immunocompetent child
Mutation
83 21931841 Environmental levels of the antiviral oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards
Mutation
84 22000086 Reverse-transcription polymerase chain reaction/pyrosequencing to characterize neuraminidase H275 residue of influenza A 2009 H1N1 virus for rapid and specific detection of the viral oseltamivir resistance marker in a clinical laboratory
Mutation
85 22260817 Mutations I117V and I117M and oseltamivir sensitivity of pandemic (H1N1) 2009 viruses
Mutation
86 22561367 Characteristics of a widespread community cluster of H275Y oseltamivir-resistant A(H1N1)pdm09 influenza in Australia
Mutation
87 22966122 Presence of oseltamivir-resistant pandemic A/H1N1 minor variants before drug therapy with subsequent selection and transmission
Mutation
88 30834715 Community spread and late season increased incidence of oseltamivir-resistant influenza A(H1N1) viruses in Norway 2016
Mutation
89 30400276 Combination Therapy with Oseltamivir and Favipiravir Delays Mortality but Does Not Prevent Oseltamivir Resistance in Immunodeficient Mice Infected with Pandemic A(H1N1) Influenza Virus
Mutation
90 39458365 The Global Trend of Drug Resistant Sites in Influenza A Virus Neuraminidase Protein from 2011 to 2020
Mutation
91 12103431 The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo
Mutation
92 19015327 Activity of the oral neuraminidase inhibitor A-322278 against the oseltamivir-resistant H274Y (A/H1N1) influenza virus mutant in mice
Mutation
93 19331731 Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 season
Mutation
94 24696271 A nonpathogenic duck-origin H9N2 influenza A virus adapts to high pathogenicity in mice
Mutation
95 19911968 Clinical effectiveness of oseltamivir and zanamivir for treatment of influenza A virus subtype H1N1 with the H274Y mutation: a Japanese, multicenter study of the 2007-2008 and 2008-2009 influenza seasons
Mutation
96 19962344 Emergence of H274Y oseltamivir-resistant A(H1N1) influenza viruses in Japan during the 2008-2009 season
Mutation
97 20202225 A two-year survey of the oseltamivir-resistant influenza A(H1N1) virus in Yamagata, Japan and the clinical effectiveness of oseltamivir and zanamivir
Mutation
98 20385168 Detection of the rapid emergence of the H275Y mutation associated with oseltamivir resistance in severe pandemic influenza virus A/H1N1 09 infections
Mutation
99 20447860 First case in Italy of acquired resistance to oseltamivir in an immunocompromised patient with influenza A/H1N1v infection
Mutation
100 20459681 Oseltamivir-resistant pandemic (H1N1)2009 in Yemen - case report
Mutation
101 31302878 Characterization of viral genomic mutations in novel influenza A (H7N9)-infected patients: the association between oseltamivir-resistant variants and viral shedding duration
Mutation
102 20513088 Antiviral drug susceptibilities of seasonal human influenza viruses in Lebanon, 2008-09 season
Mutation
103 20661429 Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets
Mutation
104 20738882 Clinical importance and impact on the households of oseltamivir-resistant seasonal A/H1N1 influenza virus in healthy children in Italy
Mutation
105 31597771 Identification of Key Amino Acids in the PB2 and M1 Proteins of H7N9 Influenza Virus That Affect Its Transmission in Guinea Pigs
Mutation
106 20836794 Oseltamivir-resistant influenza A 2009 H1N1 virus in immunocompromised patients
Mutation
107 20865125 Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses
Mutation
108 21070812 Genotypic and phenotypic resistance of pandemic A/H1N1 influenza viruses circulating in Germany
Mutation
109 21148493 Generation and characterization of recombinant pandemic influenza A(H1N1) viruses resistant to neuraminidase inhibitors
Mutation
110 21172786 Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness
Mutation
111 21543559 Ultrasensitive detection of drug-resistant pandemic 2009 (H1N1) influenza A virus by rare-variant-sensitive high-resolution melting-curve analysis
Mutation
112 21567417 Rapid discrimination of oseltamivir-resistant 275Y and -susceptible 275H substitutions in the neuraminidase gene of pandemic influenza A/H1N1 2009 virus by duplex one-step RT-PCR assay
Mutation
113 21572517 Mutation analysis of 2009 pandemic influenza A(H1N1) viruses collected in Japan during the peak phase of the pandemic
Mutation
114 21628810 Simultaneous detection and subtyping of H274Y-positive influenza A (H1N1) using pyrosequencing
Mutation
115 21767571 Oseltamivir-resistant pandemic A(H1N1) 2009 influenza viruses detected through enhanced surveillance in the Netherlands, 2009-2010
Mutation
116 22111074 First Fatal Oseltamivir-Resistant 2009 Pandemic Influenza A (H1N1) Case in an Adult in Korea
Mutation
117 22138712 The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses
Mutation
118 22203589 Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus
Mutation
119 22243670 Neuraminidase H275Y and hemagglutinin D222G mutations in a fatal case of 2009 pandemic influenza A (H1N1) virus infection
Mutation
120 22345446 Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance
Mutation
121 22532693 Enhanced mammalian transmissibility of seasonal influenza A/H1N1 viruses encoding an oseltamivir-resistant neuraminidase
Mutation
122 22535992 Recovery of influenza B virus with the H273Y point mutation in the neuraminidase active site from a human patient
Mutation
123 22661221 Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient
Mutation
124 22664977 Therapeutic activity of intramuscular peramivir in mice infected with a recombinant influenza A/WSN/33 (H1N1) virus containing the H275Y neuraminidase mutation
Mutation
125 22694153 Comparisons of oseltamivir-resistant (H275Y) and concurrent oseltamivir-susceptible seasonal influenza A(H1N1) virus infections in hospitalized adults, 2008-2009
Mutation
126 31948040 H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice
Mutation
127 22761651 Genetic characterization of human influenza viruses in the pandemic (2009-2010) and post-pandemic (2010-2011) periods in Japan
Mutation
128 22837199 The H275Y neuraminidase mutation of the pandemic A/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets
Mutation
129 23029335 Amino acids transitioning of 2009 H1N1pdm in Taiwan from 2009 to 2011
Mutation
130 23192869 Pandemic 2009 H1N1 influenza A virus carrying a Q136K mutation in the neuraminidase gene is resistant to zanamivir but exhibits reduced fitness in the guinea pig transmission model
Mutation
131 23280098 Genetic characterization of influenza virus circulating in Brazilian pigs during 2009 and 2010 reveals a high prevalence of the pandemic H1N1 subtype
Mutation
132 23397331 Influenza virus A(H1N1)pdm09 hemagglutinin polymorphism and associated disease in southern Germany during the 2010/11 influenza season
Mutation
133 23587185 Genetic diversity among pandemic 2009 influenza viruses isolated from a transmission chain
Mutation
134 23778667 Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil
Mutation
135 23791870 Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan
Mutation
136 23843978 Using high-throughput sequencing to leverage surveillance of genetic diversity and oseltamivir resistance: a pilot study during the 2009 influenza A(H1N1) pandemic
Mutation
137 23908945 Tracking oseltamivir-resistance in New Zealand influenza viruses during a medicine reclassification in 2007, a resistant-virus importation in 2008 and the 2009 pandemic
Mutation
138 23951116 Resistance mutation R292K is induced in influenza A(H6N2) virus by exposure of infected mallards to low levels of oseltamivir
Mutation
139 24078044 Molecular evolution of the hemagglutinin and neuraminidase genes of pandemic (H1N1) 2009 influenza viruses in Sendai, Japan, during 2009-2011
Mutation
140 32272175 Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza a virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution
Mutation
141 24790833 Isolation and characterization of H9N2 influenza virus isolates from poultry respiratory disease outbreak
Mutation
142 23628410 Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China
Mutation
143 24563658 Synergistic combinations of favipiravir and oseltamivir against wild-type pandemic and oseltamivir-resistant influenza A virus infections in mice
Mutation
144 24699508 Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm09 virus
Mutation
145 24734292 Peramivir and laninamivir susceptibility of circulating influenza A and B viruses
Mutation
146 24957832 Characterization of drug-resistant influenza virus A(H1N1) and A(H3N2) variants selected in vitro with laninamivir
Mutation
147 24350808 Emergence of a novel drug resistant H7N9 influenza virus: evidence based clinical potential of a natural IFN-alpha for infection control and treatment
Mutation
148 25191344 Prevalence of Oseltamivir-Resistant 2009 H1N1 Influenza Virus among Patients with Pandemic 2009 H1N1 Influenza infection in NRITLD, Tehran, Iran
Mutation
149 25301400 Characterization of human Influenza Viruses in Lebanon during 2010-2011 and 2011-2012 post-pandemic seasons
Mutation
150 25410995 Molecular findings from influenza A(H1N1)pdm09 detected in patients from a Brazilian equatorial region during the pandemic period
Mutation
151 25616792 Oseltamivir-resistant influenza A (H1N1) virus strain with an H274Y mutation in neuraminidase persists without drug pressure in infected mallards
Mutation
152 25648607 Molecular epidemiology of influenza A virus infection among hospitalized children in Vietnam during post-pandemic period
Mutation
153 25742269 Oseltamivir-resistant influenza A(H1N1)pdm2009 strains found in Brazil are endowed with permissive mutations, which compensate the loss of fitness imposed by antiviral resistance
Mutation
154 25966032 Virological characterization of influenza H1N1pdm09 in Vietnam, 2010-2013
Mutation
155 25992792 Impact of the H275Y and I223V Mutations in the Neuraminidase of the 2009 Pandemic Influenza Virus In Vitro and Evaluating Experimental Reproducibility
Mutation
156 26103966 Characteristics of oseltamivir-resistant influenza A (H1N1) pdm09 virus during the 2013-2014 influenza season in Mainland China
Mutation
157 26188087 Quantifying relative within-host replication fitness in influenza virus competition experiments
Mutation
158 26247418 Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir
Mutation
159 26464773 Prevalence of Influenza A(H1N1)pdm09 Virus Resistant to Oseltamivir in Shiraz, Iran, During 2012 - 2013
Mutation
160 39240070 Characterization of Conserved Evolution in H7N9 Avian Influenza Virus Prior Mass Vaccination
Mutation
161 27596738 Mutations at highly conserved residues in influenza A(H1N1)pdm09 virus affect neuraminidase activity
Mutation
162 27714496 Community- and hospital-acquired infections with oseltamivir- and peramivir-resistant influenza A(H1N1)pdm09 viruses during the 2015-2016 season in Japan
Mutation
163 27997573 Genetic Characterization of Circulating 2015 A(H1N1)pdm09 Influenza Viruses from Eastern India
Mutation
164 29288584 Oseltamivir-resistant influenza A(H1N1)pdm09 virus associated with high case fatality, India 2015
Mutation
165 29315673 Surveillance for antiviral resistance among influenza viruses circulating in Algeria during five consecutive influenza seasons (2009-2014)
Mutation
166 29933553 Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus
Mutation
167 30315875 Clinical management and viral genomic diversity analysis of a child's influenza A(H1N1)pdm09 infection in the context of a severe combined immunodeficiency
Mutation
168 30574137 Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil
Mutation
169 30602610 In Vitro and In Vivo Characterization of Novel Neuraminidase Substitutions in Influenza A(H1N1)pdm09 Virus Identified Using Laninamivir-Mediated In Vitro Selection
Mutation
170 30640922 Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons
Mutation
171 30926297 Molecular influenza surveillance at a tertiary university hospital during four consecutive seasons (2012-2016) in Catalonia, Spain
Mutation
172 31496532 Molecular characterization of influenza A(H1N1)pdm09 viruses circulating at various geographical locations in India, 2017
Mutation
173 32579578 Whole-genome sequencing reveals origin and evolution of influenza A(H1N1)pdm09 viruses in Lincang, China, from 2014 to 2018
Mutation
174 33213486 Phylogenetic analysis and clinical characteristics of the co-occurring mutations in HA and NA genes of influenza A(H1N1)pdm09 viruses during 2015-2017 in Beijing, China
Mutation
175 36187691 Low prevalence of influenza A strains with resistance markers in Brazil during 2017-2019 seasons
Mutation
176 31228489 Effect of influenza H1N1 neuraminidase V116A and I117V mutations on NA activity and sensitivity to NA inhibitors
Mutation
177 31773463 Source of oseltamivir resistance due to single E119D and double E119D/H274Y mutations in pdm09H1N1 influenza neuraminidase
Mutation
178 31783761 Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies
Mutation
179 32069052 Optimization of 4-Aminopiperidines as Inhibitors of Influenza A Viral Entry That Are Synergistic with Oseltamivir
Mutation
180 32159230 Antigenic drift of hemagglutinin and neuraminidase in seasonal H1N1 influenza viruses from Saudi Arabia in 2014 to 2015
Mutation
181 32393488 Laninamivir-Interferon Lambda 1 Combination Treatment Promotes Resistance by Influenza A Virus More Rapidly than Laninamivir Alone
Mutation
182 32631440 Characterization of neuraminidase inhibitor-resistant influenza virus isolates from immunocompromised patients in the Republic of Korea
Mutation
183 23990570 Novel avian-origin human influenza A(H7N9) can be transmitted between ferrets via respiratory droplets
Mutation
184 33154243 Genetic sequencing of influenza A (H1N1) pdm09 isolates from South India, collected between 2011 and 2015 to detect mutations affecting virulence and resistance to oseltamivir
Mutation
185 33605468 Investigation of genetic variation: Neuraminidase gene of influenza A virus H1N1/pdm09, Shiraz, Iran (2015-2016)
Mutation
186 33713731 Secondary substitutions in the hemagglutinin and neuraminidase genes associated with neuraminidase inhibitor resistance are rare in the Influenza Resistance Information Study (IRIS)
Mutation
187 28162820 Manipulation of neuraminidase packaging signals and hemagglutinin residues improves the growth of A/Anhui/1/2013 (H7N9) influenza vaccine virus yield in eggs
Mutation
188 39066271 Increase of Synergistic Secondary Antiviral Mutations in the Evolution of A(H1N1)pdm09 Influenza Virus Neuraminidases
Mutation
189 19626608 Surveillance and oseltamivir resistance of human influenza a virus in Turkey during the 2007-2008 season
Mutation
190 18718489 Rapid molecular detection of the H275Y oseltamivir resistance gene mutation in circulating influenza A (H1N1) viruses
Mutation
191 29265727 Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study
Mutation
192 19850010 Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand
Mutation
193 15673732 Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations
Mutation
194 21163739 Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina
Mutation
195 22160942 Genetic characteristics of 2009 pandemic H1N1 influenza a viruses isolated from Mainland China
Mutation
196 22090133 The highly conserved arginine residues at positions 76 through 78 of influenza A virus matrix protein M1 play an important role in viral replication by affecting the intracellular localization of M1
Mutation
197 24760887 Residue 41 of the Eurasian avian-like swine influenza a virus matrix protein modulates virion filament length and efficiency of contact transmission
Mutation
198 27923954 Antibodies Against the Current Influenza A(H1N1) Vaccine Strain Do Not Protect Some Individuals From Infection With Contemporary Circulating Influenza A(H1N1) Virus Strains
Mutation
199 31336147 Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient
Mutation
200 31110840 Missed detections of influenza A(H1)pdm09 by real-time RT-PCR assay due to haemagglutinin sequence mutation, December 2017 to March 2018, northern Viet Nam
Mutation
201 39444487 Influenza A virus within-host evolution and positive selection in a densely sampled household cohort over three seasons
Mutation
202 39635219 Epidemiological and genetic characterization of the influenza A (H1N1) virus in Hangzhou City in 2023
Mutation
203 20300625 Genetic characterization of the influenza A pandemic (H1N1) 2009 virus isolates from India
Mutation
204 20739532 Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models
Mutation
205 20826688 Altered receptor specificity and cell tropism of D222G hemagglutinin mutants isolated from fatal cases of pandemic A(H1N1) 2009 influenza virus
Mutation
206 34242774 Genetic and antigenic diversity of H7N9 highly pathogenic avian influenza virus in China
Mutation
207 20975994 Genetic diversity of the 2009 pandemic influenza A(H1N1) viruses in Finland
Mutation
208 21520138 Antigenic and genetic variation in the hemagglutinins of H1N1 and H3N2 human influenza a viruses in the Shanghai area from 2005 to 2008
Mutation
209 21894383 Sequence analysis of the 2009 pandemic influenza A H1N1 virus haemagglutinin gene from 2009-2010 Brazilian clinical samples
Mutation
210 21935413 Genetic structure of human A/H1N1 and A/H3N2 influenza virus on Corsica Island: phylogenetic analysis and vaccine strain match, 2006-2010
Mutation
211 39436936 The host tropism of current zoonotic H7N9 viruses depends mainly on an acid-labile hemagglutinin with a single amino acid mutation in the stalk region
Mutation
212 21966421 Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus
Mutation
213 21980333 Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection
Mutation
214 22022458 Minor changes in the hemagglutinin of influenza A(H1N1)2009 virus alter its antigenic properties
Mutation
215 22194944 Adaption of seasonal H1N1 influenza virus in mice
Mutation
216 22575875 In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient
Mutation
217 22647789 Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice
Mutation
218 22740390 Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus
Mutation
219 22809862 Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents
Mutation
220 23351651 Within-patient emergence of the influenza A(H1N1)pdm09 HA1 222G variant and clear association with severe disease, Norway
Mutation
221 23408613 Identification of critical residues in the hemagglutinin and neuraminidase of influenza virus H1N1pdm for vaccine virus replication in embryonated chicken eggs
Mutation
222 23451145 Predominance of HA-222D/G polymorphism in influenza A(H1N1)pdm09 viruses associated with fatal and severe outcomes recently circulating in Germany
Mutation
223 24109242 Evolution of the hemagglutinin protein of the new pandemic H1N1 influenza virus: maintaining optimal receptor binding by compensatory substitutions
Mutation
224 25135885 Two amino acid substitutions in the haemagglutinin of the 2009 pandemic H1N1 virus decrease direct-contact transmission in guinea pigs
Mutation
225 25601799 Comparative virulence of wild-type H1N1pdm09 influenza A isolates in swine
Mutation
226 26321885 Analysis of the Contrasting Pathogenicities Induced by the D222G Mutation in 1918 and 2009 Pandemic Influenza A Viruses
Mutation
227 26914510 Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells
Mutation
228 27020673 Interim estimates of 2015/16 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, February 2016
Mutation
229 29118117 A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells
Mutation
230 29128380 Low influenza vaccine effectiveness and the effect of previous vaccination in preventing admission with A(H1N1)pdm09 or B/Victoria-Lineage in patients 60 years old or older during the 2015/2016 influenza season
Mutation
231 29255273 Diversity of antigenic mutants of influenza A(H1N1)pdm09 virus escaped from human monoclonal antibodies
Mutation
232 29445999 The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice
Mutation
233 29753891 Pleiotropic effects of hemagglutinin amino acid substitutions of influenza A(H1N1)pdm09 virus escape mutants
Mutation
234 17251573 Adaptation of an H7N7 equine influenza A virus in mice
Mutation
235 30237955 Genetic variations of the Hemagglutinin gene of Pandemic Influenza A (H1N1) viruses in Assam, India during 2016
Mutation
236 30336188 Molecular epidemiology of the hemagglutinin gene of prevalent influenza virus A/H1N1/pdm09 among patient in Iran
Mutation
237 22146492 Two mutations in the C-terminal domain of influenza virus RNA polymerase PB2 enhance transcription by enhancing cap-1 RNA binding activity
Mutation
238 31803799 Phylogenetic analysis of the hemagglutinin gene of influenza A(H1N1)pdm09 and A(H3N2) virus isolates from Haryana, India
Mutation
239 24257603 Emergence of the virulence-associated PB2 E627K substitution in a fatal human case of highly pathogenic avian influenza virus A(H7N7) infection as determined by Illumina ultra-deep sequencing
Mutation
240 27886255 Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus
Mutation
241 30799182 Atypical influenza A(H1N1)pdm09 strains caused an influenza virus outbreak in Saudi Arabia during the 2009-2011 pandemic season
Mutation
242 31635227 Antigenic Site Variation in the Hemagglutinin of Pandemic Influenza A(H1N1)pdm09 Viruses between 2009-2017 in Ukraine
Mutation
243 19052665 Analysis of PB2 protein from H9N2 and H5N1 avian flu virus
Mutation
244 27105450 Residues in the PB2 and PA genes contribute to the pathogenicity of avian H7N3 influenza A virus in DBA/2 mice
Mutation
245 32847862 Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain
Mutation
246 33914831 Evaluation of HA-D222G/N polymorphism using targeted NGS analysis in A(H1N1)pdm09 influenza virus in Russia in 2018-2019
Mutation
247 29540597 Antigenically Diverse Swine Origin H1N1 Variant Influenza Viruses Exhibit Differential Ferret Pathogenesis and Transmission Phenotypes
Mutation
248 31175183 The L46P mutant confers a novel allosteric mechanism of resistance toward the influenza A virus M2 S31N proton channel blockers
Mutation
249 23717200 Prolonged influenza virus shedding and emergence of antiviral resistance in immunocompromised patients and ferrets
Mutation
250 22696672 Persistent oseltamivir-resistant pandemic influenza A/H1N1 infection in an adult with cystic fibrosis
Mutation
251 28128091 Development of oseltamivir and zanamivir resistance in influenza A(H1N1)pdm09 virus, Denmark, 2014
Mutation
252 29453856 Defective RNA sensing by RIG-I in severe influenza virus infection
Mutation
253 39817904 Probing the functional constraints of influenza A virus NEP by deep mutational scanning
Mutation
254 20335065 Oseltamivir-induced resistant pandemic A/H1N1 influenza virus in a child with cystic fibrosis and Pseudomonas aeruginosa infection
Mutation
255 22194826 Segregation of virulent influenza A(H1N1) variants in the lower respiratory tract of critically ill patients during the 2010-2011 seasonal epidemic
Mutation
256 27193582 Mechanisms of Action of Novel Influenza A/M2 Viroporin Inhibitors Derived from Hexamethylene Amiloride
Mutation
257 23122228 Neutralizing and protective epitopes of the 2009 pandemic influenza H1N1 hemagglutinin
Mutation
258 23307376 Pathobiology and virus shedding of low-pathogenic avian influenza virus (A/H1N1) infection in mallards exposed to oseltamivir
Mutation
259 25081940 Prolonged shedding of pandemic influenza A (H1N1) 2009 virus in a pancreas-after-kidney transplant recipient
Mutation
260 27336226 Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016
Mutation
261 27268229 Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China
Mutation
262 28116526 Genetic properties and pathogenicity of a novel reassortant H10N5 influenza virus from wild birds
Mutation
263 24696487 Airborne transmission of highly pathogenic H7N1 influenza virus in ferrets
Mutation
264 16963558 Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling
Mutation
265 25793397 Characterization of a novel mutation in NS1 protein of influenza A virus induced by a chemical substance for the attenuation of pathogenicity
Mutation
266 26038410 Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing
Mutation
267 29981696 Novel mutations in avian PA in combination with an adaptive mutation in PR8 NP exacerbate the virulence of PR8-derived recombinant influenza A viruses in mice
Mutation
268 29167343 Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein Is Crucial for Production of Infectious Virus Particles
Mutation
269 39606665 Influenza A virus shedding and reinfection during the post-weaning period in swine: longitudinal study of two nurseries
Mutation
270 12692212 Mutations in the N-terminal region of influenza virus PB2 protein affect virus RNA replication but not transcription
Mutation
271 16242167 Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses
Mutation
272 24403580 Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice
Mutation
273 12186883 A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs
Mutation
274 12663810 A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs
Mutation
275 12719592 Threonine 157 of influenza virus PA polymerase subunit modulates RNA replication in infectious viruses
Mutation
276 15280506 Functional compensation of a detrimental amino acid substitution in a cytotoxic-T-lymphocyte epitope of influenza a viruses by comutations
Mutation
277 15914859 Full restoration of viral fitness by multiple compensatory co-mutations in the nucleoprotein of influenza A virus cytotoxic T-lymphocyte escape mutants
Mutation
278 18987140 Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions
Mutation
279 16627618 The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway
Mutation
280 22525464 A single point mutation (Y89F) within the non-structural protein 1 of influenza A viruses limits epithelial cell tropism and virulence in mice
Mutation
281 22993153 Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence
Mutation
282 28250123 Influenza A Virus Virulence Depends on Two Amino Acids in the N-Terminal Domain of Its NS1 Protein To Facilitate Inhibition of the RNA-Dependent Protein Kinase PKR
Mutation
283 25275121 A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus
Mutation
284 8918554 Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme
Mutation
285 9683567 Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase
Mutation
286 19943705 Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses
Mutation
287 21253602 Detection of resistance mutations to antivirals oseltamivir and zanamivir in avian influenza A viruses isolated from wild birds
Mutation
288 25234090 Dextran sulfate-resistant A/Puerto Rico/8/34 influenza virus is associated with the emergence of specific mutations in the neuraminidase glycoprotein
Mutation
289 27659246 Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background
Mutation
290 30365885 Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant
Mutation
291 31645133 Peramivir binding affinity with influenza A neuraminidase and research on its mutations using an induced-fit docking approach
Mutation
292 30429954 Structure-Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers
Mutation
293 32599753 Virtual Screening Identifies Chebulagic Acid as an Inhibitor of the M2(S31N) Viral Ion Channel and Influenza A Virus
Mutation
294 29209052 Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication
Mutation
295 32709116 Genetic Characterization of a Novel North American-Origin Avian Influenza A (H6N5) Virus Isolated from Bean Goose of South Korea in 2018
Mutation
296 18353965 Infectivity studies of influenza virus hemagglutinin receptor binding site mutants in mice
Mutation
297 25653452 Influenza hemagglutinin (HA) stem region mutations that stabilize or destabilize the structure of multiple HA subtypes
Mutation
298 28338150 Stereoselective synthesis of novel adamantane derivatives with high potency against rimantadine-resistant influenza A virus strains
Mutation
299 39811135 Mining Druggable Sites in Influenza A Hemagglutinin: Binding of the Pinanamine-Based Inhibitor M090
Mutation
300 23437033 Quantitative description of glycan-receptor binding of influenza A virus H7 hemagglutinin
Mutation
301 21216958 Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly
Mutation
302 19383794 Mechanism of drug inhibition and drug resistance of influenza A M2 channel
Mutation
303 23451169 Simultaneous detection of oseltamivir- and amantadine-resistant influenza by oligonucleotide microarray visualization
Mutation
304 9696865 The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction
Mutation
305 9559786 Generation and characterization of a mutant of influenza A virus selected with the neuraminidase inhibitor BCX-140
Mutation
306 29489903 Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase
Mutation
307 11773097 Detection of amantadine-resistant influenza A virus strains in nursing homes by PCR-restriction fragment length polymorphism analysis with nasopharyngeal swabs
Mutation
308 11773413 Influenza a virus M2 ion channel activity is essential for efficient replication in tissue culture
Mutation
309 20833142 Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
Mutation
310 17384070 Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus
Mutation
311 36745654 Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses
Mutation
312 35938724 Effect of Baloxavir and Oseltamivir in Combination on Infection with Influenza Viruses with PA/I38T or PA/E23K Substitutions in the Ferret Model
Mutation
313 39533190 An epidemiologic surveillance study based on wastewater and respiratory specimens reveals influenza a virus prevalence and mutations in Taiyuan, China during 2023-2024
Mutation
314 37343022 TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1
Mutation
315 30084768 Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice
Mutation
316 38139214 The Effect of Mice Adaptation Process on the Pathogenicity of Influenza A/South Africa/3626/2013 (H1N1)pdm09 Model Strain
Mutation
317 38054704 Twenty natural amino acid substitution screening at the last residue 121 of influenza A virus NS2 protein reveals the critical role of NS2 in promoting virus genome replication by coordinating with viral polymerase
Mutation
318 23269805 Amino acid 316 of hemagglutinin and the neuraminidase stalk length influence virulence of H9N2 influenza virus in chickens and mice
Mutation
319 34427541 Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses
Mutation
320 34888217 Studying the Effect of Amino Acid Substitutions in the M2 Ion Channel of the Influenza Virus on the Antiviral Activity of the Aminoadamantane Derivative In Vitro and In Silico
Mutation
321 38854978 Molecular characterization and evolutionary dynamics of influenza A(H1N1) strains isolated from 2015 to 2017 in North India
Mutation
322 35627294 Mutation in Hemagglutinin Antigenic Sites in Influenza A pH1N1 Viruses from 2015-2019 in the United States Mountain West, Europe, and the Northern Hemisphere
Mutation
323 37006623 Evolution of Indian Influenza A (H1N1) Hemagglutinin Strains: A Comparative Analysis of the Pandemic Californian HA Strain
Mutation
324 30050898 Structurally Diverse Polyketides From the Mangrove-Derived Fungus Diaporthe sp. SCSIO 41011 With Their Anti-influenza A Virus Activities
Mutation
325 37068231 Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies
Mutation
326 29312300 Histone Deacetylase 1 Plays an Acetylation-Independent Role in Influenza A Virus Replication
Mutation
327 34985907 Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior
Mutation
328 30509291 Conserved methionine 165 of matrix protein contributes to the nuclear import and is essential for influenza A virus replication
Mutation
329 35215907 Human SUMOylation Pathway Is Critical for Influenza B Virus
Mutation
330 24136722 Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan
Mutation
331 25187542 A histidine residue of the influenza virus hemagglutinin controls the pH dependence of the conformational change mediating membrane fusion
Mutation
332 39737954 A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth
Mutation
333 23917311 Bioluminescence-based neuraminidase inhibition assay for monitoring influenza virus drug susceptibility in clinical specimens
Mutation
334 37436149 Bioinformatics and Structural Analysis of Antigenic Variation in the Hemagglutinin Gene of the Influenza A(H1N1)pdm09 Virus Circulating in Shiraz (2013 to 2015)
Mutation
335 23759670 Virological self-sampling to monitor influenza antiviral susceptibility in a community cohort
Mutation
336 25066276 Development and clinical testing of a simple, low-density gel element array for influenza identification, subtyping, and H275Y detection
Mutation
337 21504394 Oseltamivir-resistant influenza viruses get by with a little help from permissive mutations
Mutation
338 20047917 Laninamivir prodrug CS-8958, a long-acting neuraminidase inhibitor, shows superior anti-influenza virus activity after a single administration
Mutation
339 21808039 Putative amino acid determinants of the emergence of the 2009 influenza A (H1N1) virus in the human population
Mutation
340 23894575 Analysis of adaptation mutants in the hemagglutinin of the influenza A(H1N1)pdm09 virus
Mutation
341 21306576 Influenza and other respiratory viruses in three Central American countries
Mutation
342 39507787 Genetic characterization of low-pathogenic avian influenza subtypes H10N6 and H10N7 from free-grazing ducks in Thailand
Mutation
343 21173148 Only two residues are responsible for the dramatic difference in receptor binding between swine and new pandemic H1 hemagglutinin
Mutation
344 38112470 A naturally occurring HA-stabilizing amino acid (HA1-Y17) in an A(H9N2) low-pathogenic influenza virus contributes to airborne transmission
Mutation
345 35706014 HA gene amino acid mutations contribute to antigenic variation and immune escape of H9N2 influenza virus
Mutation
346 33735274 Hemagglutination Inhibition (HAI) antibody landscapes after vaccination with H7Nx virus like particles
Mutation
347 35889251 Structural Investigations and Binding Mechanisms of Oseltamivir Drug Resistance Conferred by the E119V Mutation in Influenza H7N9 Virus
Mutation
348 37383151 Glycosylation of H4 influenza strains with pandemic potential and susceptibilities to lung surfactant SP-D
Mutation
349 37380173 Evidence that HA-G228S and PB2-D153V mutations upon viral growth of H3N8 influenza virus are associated with severe pathogenesis in human infections
Mutation
350 36366429 Increased Polymerase Activity of Zoonotic H7N9 Allows Partial Escape from MxA
Mutation
351 36975535 Development of Digital Droplet PCR Targeting the Influenza H3N2 Oseltamivir-Resistant E119V Mutation and Its Performance through the Use of Reverse Genetics Mutants
Mutation
352 36560687 Matrix-Encoding Gene Diversity of 624 Influenza A/H3N2 Genomes Does Not Show Association with Impaired Viral Detection by Commercialized qPCR Assays
Mutation
353 38890325 Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin
Mutation
354 36155668 Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution
Mutation
355 39104583 The V223I substitution in hemagglutinin reduces the binding affinity to human-type receptors while enhancing the thermal stability of the H3N2 canine influenza virus
Mutation
356 37979619 Naturally occurring PA(E206K) point mutation in 2009 H1N1 pandemic influenza viruses impairs viral replication at high temperatures
Mutation
357 28754164 Data-driven interdisciplinary mathematical modelling quantitatively unveils competition dynamics of co-circulating influenza strains
Mutation
358 35324585 Genetic Analysis of Influenza A/H1N1pdm Strains Isolated in Bangladesh in Early 2020
Mutation
359 35867563 Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution
Mutation
360 37193052 Discovery of oseltamivir-based novel PROTACs as degraders targeting neuraminidase to combat H1N1 influenza virus
Mutation
361 37490957 Phylogenetic analysis and docking study of neuraminidase gene of influenza A/H1N1 viruses circulating in Iran from 2010 to 2019
Mutation
362 35622874 Haemagglutinin substitutions N125D, D127E, D222G and R223Q improve replicative fitness and vaccine effectiveness of an A/H1N1pdm09 live attenuated influenza vaccine virus by enhancing alpha-2,6 receptor binding
Mutation
363 38772446 Preparation and characterization of mouse-derived monoclonal antibodies against the hemagglutinin of the H1N1 influenza virus
Mutation
364 38871182 Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals
Mutation
365 38364702 Assessment of the antigenic evolution of a clade 6B.1 human H1N1pdm influenza virus revealed differences between ferret and human convalescent sera
Mutation
366 19641000 Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
Mutation
367 32887429 In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients
Mutation
368 20409386 Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus
Mutation
369 28465552 A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine
Mutation
370 25339773 Virulence determinants in the PB2 gene of a mouse-adapted H9N2 virus
Mutation
371 19946717 Readaptation of a low-virulence influenza H9 escape mutant in mice: the role of changes in hemagglutinin as revealed by site-specific mutagenesis
Mutation
372 21849466 Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein
Mutation
373 23199027 Sequence and phylogenetic analysis of highly pathogenic avian influenza H5N1 viruses isolated during 2006-2008 outbreaks in Pakistan reveals genetic diversity
Mutation
374 16479508 Recovery of drug-resistant influenza virus from immunocompromised patients: a case series
Mutation
375 23335741 Virus susceptibility analyses from a phase IV clinical trial of inhaled zanamivir treatment in children infected with influenza
Mutation
376 30349332 Antiviral resistance markers in influenza virus sequences in Mexico, 2000-2017
Mutation
377 29409570 Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018
Mutation
378 39597751 Antigenic Divergence from the Seasonal Vaccine of the Influenza Virus Strains Circulating in Romania During Three Successive Seasons (2021-2024)
Mutation
379 33568453 Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase
Mutation
380 16912325 Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses
Mutation
381 21994620 Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective
Mutation
382 24279698 Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China
Mutation
383 25609803 Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice
Mutation
384 27849220 Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient
Mutation
385 29489060 Molecular genetic characteristics of influenza A virus clinically isolated during 2011-2016 influenza seasons in Korea
Mutation
386 30548432 Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan
Mutation
387 32004620 Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017-2018
Mutation
388 25721488 Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014
Mutation
389 22848649 Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses
Mutation
390 27586413 Effects of hemagglutinin amino acid substitutions in H9 influenza A virus escape mutants
Mutation
391 39802823 Comprehensive molecular epidemiology of influenza viruses in Brazil: insights from a nationwide analysis
Mutation
392 28132927 Antigenic and genetic characterization of influenza viruses circulating in Bulgaria during the 2015/2016 season
Mutation
393 31852473 Continuing evolution of H6N2 influenza a virus in South African chickens and the implications for diagnosis and control
Mutation
394 32064779 Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil
Mutation
395 29145498 Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins
Mutation
396 20592084 Adaptation of pandemic H1N1 influenza viruses in mice
Mutation
397 21698272 Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo
Mutation
398 35446141 Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies
Mutation
399 23251479 Whole genome characterization, phylogenetic and genome signature analysis of human pandemic H1N1 virus in Thailand, 2009-2012
Mutation
400 26453960 A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice
Mutation
401 20976194 Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype?
Mutation
402 20522774 Permissive secondary mutations enable the evolution of influenza oseltamivir resistance
Mutation
403 21470455 H275Y mutant pandemic (H1N1) 2009 virus in immunocompromised patients
Mutation
404 22811535 Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation
Mutation
405 22970161 Exploring the mechanism of zanamivir resistance in a neuraminidase mutant: a molecular dynamics study
Mutation
406 25297528 Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses
Mutation
407 31697721 Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza
Mutation
408 26345289 Influenza virus surveillance in Argentina during the 2012 season: antigenic characterization, genetic analysis and antiviral susceptibility
Mutation
409 20205961 Circulation of human influenza viruses and emergence of Oseltamivir-resistant A(H1N1) viruses in Cameroon, Central Africa
Mutation
410 25297358 Antiviral drug profile of human influenza A & B viruses circulating in India: 2004-2011
Mutation
411 20345239 Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts
Mutation
412 21470465 Drug-resistant pandemic (H1N1) 2009, South Korea
Mutation
413 22013054 Amino acid changes in hemagglutinin contribute to the replication of oseltamivir-resistant H1N1 influenza viruses
Mutation
414 26422258 Oseltamivir Resistance in Influenza A(H6N2) Caused by an R292K Substitution in Neuraminidase Is Not Maintained in Mallards without Drug Pressure
Mutation
415 23442314 Spread of Influenza A(H1N1) oseltamivir-resistant viruses in Africa in 2008 confirmed by multiple introductions in Senegal
Mutation
416 28814737 Susceptibility of influenza A(H1N1)/pdm2009, seasonal A(H3N2) and B viruses to Oseltamivir in Guangdong, China between 2009 and 2014
Mutation
417 30971204 Epidemiological and genetic characterization of pH1N1 and H3N2 influenza viruses circulated in MENA region during 2009-2017
Mutation
418 31356626 Severe cases of seasonal influenza in Russia in 2017-2018
Mutation
419 32256457 Identification of Chebulinic Acid and Chebulagic Acid as Novel Influenza Viral Neuraminidase Inhibitors
Mutation
420 22808250 Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence
Mutation
421 28802866 Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015-2016
Mutation
422 22328930 Emerged HA and NA mutants of the pandemic influenza H1N1 viruses with increasing epidemiological significance in Taipei and Kaohsiung, Taiwan, 2009-10
Mutation
423 23369604 A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico
Mutation
424 23927713 A(H1N1)pdm09 hemagglutinin D222G and D222N variants are frequently harbored by patients requiring extracorporeal membrane oxygenation and advanced respiratory assistance for severe A(H1N1)pdm09 infection
Mutation
425 21799795 A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase
Mutation
426 23930018 Molecular distribution of amino acid substitutions on neuraminidase from the 2009 (H1N1) human influenza pandemic virus
Mutation
427 25340711 Epidemiological and virological characteristics of influenza viruses circulating in Cambodia from 2009 to 2011
Mutation
428 39296541 Baloxavir Resistance Markers in Influenza A and B Viruses in the Americas
Mutation
429 32547518 Characterization of Influenza A and B Viruses Circulating in Southern China During the 2017-2018 Season
Mutation
430 24394699 The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus
Mutation
431 29941893 Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
Mutation
432 26583707 Influenza A(H6N1) Virus in Dogs, Taiwan
Mutation
433 31538644 Baloxavir Marboxil in Japanese Pediatric Patients With Influenza: Safety and Clinical and Virologic Outcomes
Mutation
434 29023600 Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients
Mutation
435 39037444 Structure and dynamics of the proton-selective histidine and the gating tryptophan in an inward rectifying hybrid influenza B and A virus M2 proton channel
Mutation
436 32629810 Replication of a Dog-Origin H6N1 Influenza Virus in Cell Culture and Mice
Mutation
437 18191435 A cluster of conserved basic amino acids near the C-terminus of the PB1 subunit of the influenza virus RNA polymerase is involved in the regulation of viral transcription
Mutation
438 29691337 Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors
Mutation
439 12821478 Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir
Mutation
440 39659606 Molecular dynamics study on the effect of the N1 neuraminidase double mutant G147R/H274Y on oseltamivir sensitivity
Mutation
441 27486041 Discovery of Potential, Non-Toxic Influenza Virus Inhibitor by Computational Techniques
Mutation
442 30165308 Selection of influenza virus resistant to the novel camphor-based antiviral camphecene results in loss of pathogenicity
Mutation
443 11709315 Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants
Mutation
444 23575174 Neuraminidase inhibitor susceptibility surveillance of influenza viruses circulating worldwide during the 2011 Southern Hemisphere season
Mutation
445 12574276 Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network
Mutation
446 25043638 Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013
Mutation
447 28694323 A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors
Mutation
448 25766295 Structure and receptor binding of the hemagglutinin from a human H6N1 influenza virus
Mutation
449 37404185 Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility
Mutation
450 34388979 Use of hemagglutinin and neuraminidase amplicon-based high-throughput sequencing with variant analysis to detect co-infection and resolve identical consensus sequences of seasonal influenza in a university setting
Mutation
451 39593174 Genomic surveillance and evolutionary dynamics of influenza a virus in Sri Lanka
Mutation
452 27215706 Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015
Mutation
453 32285202 Genetic variability of avian influenza virus subtype H5N8 in Egypt in 2017 and 2018
Mutation
454 29299528 Human Clade 2.3.4.4 A/H5N6 Influenza Virus Lacks Mammalian Adaptation Markers and Does Not Transmit via the Airborne Route between Ferrets
Mutation
455 29090366 PB2 and HA mutations increase the virulence of highly pathogenic H5N5 clade 2.3.4.4 avian influenza virus in mice
Mutation
456 26246579 Hemagglutinin-Neuraminidase Balance Influences the Virulence Phenotype of a Recombinant H5N3 Influenza A Virus Possessing a Polybasic HA0 Cleavage Site
Mutation
457 29965752 Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant
Mutation
458 22398291 Attenuated influenza virus construct with enhanced hemagglutinin protein expression
Mutation
459 39528494 Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission
Mutation
460 18325270 Mutations in influenza A virus (H5N1) and possible limited spread, Turkey, 2006
Mutation
461 19052090 PB2 protein of a highly pathogenic avian influenza virus strain A/chicken/Yamaguchi/7/2004 (H5N1) determines its replication potential in pigs
Mutation
462 20181719 PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells
Mutation
463 20631125 Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase
Mutation
464 21367983 PB1-mediated virulence attenuation of H5N1 influenza virus in mice is associated with PB2
Mutation
465 21971186 The influenza A virus protein PB1-F2: killing two birds with one stone?
Mutation
466 26339046 Molecular Determinants of Virulence and Stability of a Reporter-Expressing H5N1 Influenza A Virus
Mutation
467 29164401 Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015
Mutation
468 30909490 The PB2 Polymerase Host Adaptation Substitutions Prime Avian Indonesia Sub Clade 2.1 H5N1 Viruses for Infecting Humans
Mutation
469 33028722 PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range
Mutation
470 17553873 Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks
Mutation
471 26391278 Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models
Mutation
472 20660199 Differential localization and function of PB1-F2 derived from different strains of influenza A virus
Mutation
473 22621130 The new temperature-sensitive mutation PA-F35S for developing recombinant avian live attenuated H5N1 influenza vaccine
Mutation
474 19494010 Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein
Mutation
475 29070694 Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor
Mutation
476 28498306 A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection
Mutation
477 17917748 Homology modeling and examination of the effect of the D92E mutation on the H5N1 nonstructural protein NS1 effector domain
Mutation
478 23124793 Methionine-101 from one strain of H5N1 NS1 protein determines its IFN-antagonizing ability and subcellular distribution pattern
Mutation
479 23886034 Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30
Mutation
480 24120936 Pathogenicity in domestic ducks and mice of highly pathogenic H5N1 clade 2.3.2.1 influenza viruses recently circulating in Eastern Asia
Mutation
481 28837667 Influenza NS1 directly modulates Hedgehog signaling during infection
Mutation
482 29677653 Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells
Mutation
483 33126184 The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding
Mutation
484 28744280 Amino Acid Substitution K470R in the Nucleoprotein Increases the Virulence of H5N1 Influenza A Virus in Mammals
Mutation
485 18836532 Influenza A H5N1 clade 2.3.4 virus with a different antiviral susceptibility profile replaced clade 1 virus in humans in northern Vietnam
Mutation
486 17855542 Neuraminidase inhibitor-resistant recombinant A/Vietnam/1203/04 (H5N1) influenza viruses retain their replication efficiency and pathogenicity in vitro and in vivo
Mutation
487 18584938 Another look at the molecular mechanism of the resistance of H5N1 influenza A virus neuraminidase (NA) to oseltamivir (OTV)
Mutation
488 19309695 Computational studies of H5N1 influenza virus resistance to oseltamivir
Mutation
489 19651908 In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses
Mutation
490 21367898 Effect of an asparagine-to-serine mutation at position 294 in neuraminidase on the pathogenicity of highly pathogenic H5N1 influenza A virus
Mutation
491 22379077 Decreased neuraminidase activity is important for the adaptation of H5N1 influenza virus to human airway epithelium
Mutation
492 23053629 Molecular mechanisms underlying oseltamivir resistance mediated by an I117V substitution in the neuraminidase of subtype H5N1 avian influenza A viruses
Mutation
493 29574145 Identification of Indonesian clade 2.1 highly pathogenic influenza A(H5N1) viruses with N294S and S246N neuraminidase substitutions which further reduce oseltamivir susceptibility
Mutation
494 18996090 An in-depth analysis of the biological functional studies based on the NMR M2 channel structure of influenza A virus
Mutation
495 31669761 Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N/L26I and M2-S31N/V27A from the influenza A viruses
Mutation
496 19116267 Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread
Mutation
497 19923184 The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks
Mutation
498 21343450 Neuraminidase inhibitor sensitivity and receptor-binding specificity of Cambodian clade 1 highly pathogenic H5N1 influenza virus
Mutation
499 21536025 CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry
Mutation
500 22301136 Residue Y161 of influenza virus hemagglutinin is involved in viral recognition of sialylated complexes from different hosts
Mutation
501 23211427 Characterization of mutations associated with the adaptation of a low-pathogenic H5N1 avian influenza virus to chicken embryos
Mutation
502 23408622 A single amino acid at the hemagglutinin cleavage site contributes to the pathogenicity but not the transmission of Egyptian highly pathogenic H5N1 influenza virus in chickens
Mutation
503 23449784 The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice
Mutation
504 23824818 Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets
Mutation
505 25998916 H5N1 influenza A virus with K193E and G225E double mutations in haemagglutinin is attenuated and immunogenic in mice
Mutation
506 26089289 Mouse lung-adapted mutation of E190G in hemagglutinin from H5N1 influenza virus contributes to attenuation in mice
Mutation
507 26874012 Enhancement of the safety of live influenza vaccine by attenuating mutations from cold-adapted hemagglutinin
Mutation
508 28100622 Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response
Mutation
509 33424035 The Effect of I155T, K156Q, K156E and N186K Mutations in Hemagglutinin on the Virulence and Reproduction of Influenza A/H5N1 Viruses
Mutation
510 27587808 H9N2 Influenza A Virus Isolated from a Greater White-Fronted Wild Goose (Anser albifrons) in Alaska Has a Mutation in the PB2 Gene, Which Is Associated with Pathogenicity in Human Pandemic 2009 H1N1
Mutation
511 39531474 Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance
Mutation
512 40320528 Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection
Mutation
513 33840358 PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals
Mutation
514 28835506 The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression
Mutation
515 31810278 Equine Mx1 Restricts Influenza A Virus Replication by Targeting at Distinct Site of its Nucleoprotein
Mutation
516 23895699 A novel reassortant H3N8 influenza virus isolated from drinking water for duck in a domestic duck farm in Poyang Lake area
Mutation
517 29997206 Mutation W222L at the Receptor Binding Site of Hemagglutinin Could Facilitate Viral Adaption from Equine Influenza A(H3N8) Virus to Dogs
Mutation
518 32433222 Baloxavir Marboxil 2% Granules in Japanese Children With Influenza: An Open-label Phase 3 Study
Mutation
519 26608955 Zanamivir-resistant influenza viruses with Q136K or Q136R neuraminidase residue mutations can arise during MDCK cell culture creating challenges for antiviral susceptibility monitoring
Mutation
520 29175013 The PB2-K627E mutation attenuates H3N2 swine influenza virus in cultured cells and in mice
Mutation
521 30353004 Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit
Mutation
522 31173771 Two mutations in viral protein enhance the adaptation of waterfowl-origin H3N2 virus in murine model
Mutation
523 22815274 Strain-dependent effects of PB1-F2 of triple-reassortant H3N2 influenza viruses in swine
Mutation
524 34033262 Evolution of the PB1 gene of human influenza A (H3N2) viruses circulating between 1968 and 2019
Mutation
525 30914078 Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic subunit I38T substitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019
Mutation
526 30670142 Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018
Mutation
527 31436527 Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019
Mutation
528 20863862 Redundancy of the influenza A virus-specific cytotoxic T lymphocyte response in HLA-B*2705 transgenic mice limits the impact of a mutation in the immunodominant NP(383-391) epitope on influenza pathogenesis
Mutation
529 25246391 Multiple influenza A (H3N2) mutations conferring resistance to neuraminidase inhibitors in a bone marrow transplant recipient
Mutation
530 18983930 Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis
Mutation
531 33075446 V292I mutation in PB2 polymerase induces increased effects of E627K on influenza H7N9 virus replication in cells
Mutation
532 27535054 NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses
Mutation
533 28003482 NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses
Mutation
534 29607359 Molecular analysis of hemagglutinin, neuraminidase, matrix genes provide insight into the genetic diversity of seasonal H3N2 human influenza a viruses in Bangladesh during July-August, 2012
Mutation
535 10888619 Antigenic drift in the influenza A virus (H3N2) nucleoprotein and escape from recognition by cytotoxic T lymphocytes
Mutation
536 34164347 Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
Mutation
537 24599981 Emergence of G186D mutation in the presence of R292K mutation in an immunocompromised child infected with influenza A/H3N2 virus, treated with oseltamivir
Mutation
538 12062395 Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets
Mutation
539 15337401 Resistant influenza A viruses in children treated with oseltamivir: descriptive study
Mutation
540 16189083 Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility
Mutation
541 16891631 Mutations conferring zanamivir resistance in human influenza virus N2 neuraminidases compromise virus fitness and are not stably maintained in vitro
Mutation
542 18065262 Impact of influenza A virus neuraminidase mutations on the stability, activity, and sensibility of the neuraminidase to neuraminidase inhibitors
Mutation
543 18648550 Seasonality of influenza A(H3N2) virus: a Hong Kong perspective (1997-2006)
Mutation
544 19157971 Emergence of oseltamivir-resistant influenza A/H3N2 virus with altered hemagglutination pattern in a hematopoietic stem cell transplant recipient
Mutation
545 20410266 Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment?
Mutation
546 21048522 Oseltamivir-resistant influenza A and B viruses pre- and postantiviral therapy in children and young adults with cancer
Mutation
547 21106781 The I222V neuraminidase mutation has a compensatory role in replication of an oseltamivir-resistant influenza virus A/H3N2 E119V mutant
Mutation
548 24088848 Emergence of an oseltamivir-resistant influenza A/H3N2 virus in an elderly patient receiving a suboptimal dose of antiviral prophylaxis
Mutation
549 25588658 Detection of a transient R292K mutation in influenza A/H3N2 viruses shed for several weeks by an immunocompromised patient
Mutation
550 25635767 Molecular surveillance of antiviral drug resistance of influenza A/H3N2 virus in Singapore, 2009-2013
Mutation
551 27374689 Persistent Infection of Drug-resistant Influenza A Virus during Chemotherapy for Malignant Lymphoma
Mutation
552 27442795 Oseltamivir resistance in an influenza A (H3N2) virus isolated from an immunocompromised patient during the 2014-2015 influenza season in Alberta, Canada
Mutation
553 29324781 Neuraminidase inhibitor susceptibility and neuraminidase enzyme kinetics of human influenza A and B viruses circulating in Thailand in 2010-2015
Mutation
554 30024940 Influenza A/H3N2 virus infection in immunocompromised ferrets and emergence of antiviral resistance
Mutation
555 32631240 Successful treatment with baloxavir marboxil of a patient with peramivir-resistant influenza A/H3N2 with a dual E119D/R292K substitution after allogeneic hematopoietic cell transplantation: a case report
Mutation
556 34240696 Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission, United Kingdom, 2018/19 influenza season
Mutation
557 28323816 An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
Mutation
558 19321726 Influenza antiviral resistance testing in new york and wisconsin, 2006 to 2008: methodology and surveillance data
Mutation
559 19537916 Amantadine-resistant influenza A (H3N2) viruses in Iran
Mutation
560 18845822 Emergence of amantadine-resistant H3N2 avian influenza A virus in South Korea
Mutation
561 19591877 Dynamics of antiviral-resistant influenza viruses in the Netherlands, 2005-2008
Mutation
562 20816700 Amantadine resistance in relation to the evolution of influenza A(H3N2) viruses in Iran
Mutation
563 20202427 Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs
Mutation
564 28877235 Genetic and antigenic characterization of influenza A(H3N2) in Cameroon during the 2014-2016 influenza seasons
Mutation
565 39748885 Two genotypes of H3N2 swine influenza viruses identified in pigs from Shandong Province, China
Mutation
566 19453470 Genetic analysis of H3N2 influenza A viruses isolated in 2006-2007 in Nairobi, Kenya
Mutation
567 36367115 Nonpharmaceutical interventions for COVID-19 disrupt the dynamic balance between influenza A virus and human immunity
Mutation
568 26378170 Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus
Mutation
569 11675142 Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201
Mutation
570 19502107 Co-circulation of two genetically distinct sub-groups of A/H3N2 influenza strains during the 2006-2007 epidemic season in Corsica Island, France
Mutation
571 21406268 Mutations affecting the stability of the haemagglutinin molecule impair the immunogenicity of live attenuated H3N2 intranasal influenza vaccine candidates lacking NS1
Mutation
572 23588737 Comparison of influenza virus replication fidelity in vitro using selection pressure with monoclonal antibodies
Mutation
573 23824816 Single hemagglutinin mutations that alter both antigenicity and receptor binding avidity influence influenza virus antigenic clustering
Mutation
574 26055368 Emergence of H7N9 Influenza A Virus Resistant to Neuraminidase Inhibitors in Nonhuman Primates
Mutation
575 25999284 Egg-adaptive mutations in H3N2v vaccine virus enhance egg-based production without loss of antigenicity or immunogenicity
Mutation
576 26077257 Influenza A(H7N9) virus acquires resistance-related neuraminidase I222T substitution when infected mallards are exposed to low levels of oseltamivir in water
Mutation
577 24165891 Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses
Mutation
578 24211668 A novel pyrosequencing assay for the detection of neuraminidase inhibitor resistance-conferring mutations among clinical isolates of avian H7N9 influenza virus
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.