Overview of IV associated (Mutation)

ID Literature Title Group
1 19641000 Zanamivir-resistant influenza viruses with a novel neuraminidase mutation
Mutation
2 32887429 In Vitro Characterization of Multidrug-Resistant Influenza A(H1N1)pdm09 Viruses Carrying a Dual Neuraminidase Mutation Isolated from Immunocompromised Patients
Mutation
3 20409386 Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus
Mutation
4 28465552 A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine
Mutation
5 25339773 Virulence determinants in the PB2 gene of a mouse-adapted H9N2 virus
Mutation
6 19946717 Readaptation of a low-virulence influenza H9 escape mutant in mice: the role of changes in hemagglutinin as revealed by site-specific mutagenesis
Mutation
7 21849466 Reversion of PB2-627E to -627K during replication of an H5N1 Clade 2.2 virus in mammalian hosts depends on the origin of the nucleoprotein
Mutation
8 23199027 Sequence and phylogenetic analysis of highly pathogenic avian influenza H5N1 viruses isolated during 2006-2008 outbreaks in Pakistan reveals genetic diversity
Mutation
9 16479508 Recovery of drug-resistant influenza virus from immunocompromised patients: a case series
Mutation
10 23335741 Virus susceptibility analyses from a phase IV clinical trial of inhaled zanamivir treatment in children infected with influenza
Mutation
11 30349332 Antiviral resistance markers in influenza virus sequences in Mexico, 2000-2017
Mutation
12 29409570 Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018
Mutation
13 39597751 Antigenic Divergence from the Seasonal Vaccine of the Influenza Virus Strains Circulating in Romania During Three Successive Seasons (2021-2024)
Mutation
14 39557155 Virological and Clinical Outcomes of Influenza Outpatients Treated With Baloxavir, Oseltamivir, or Laninamivir in the 2023-2024 Season
Mutation
15 33568453 Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase
Mutation
16 16912325 Importance of neuraminidase active-site residues to the neuraminidase inhibitor resistance of influenza viruses
Mutation
17 21994620 Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective
Mutation
18 24279698 Genetic mutations in influenza H3N2 viruses from a 2012 epidemic in Southern China
Mutation
19 25609803 Influenza viruses with receptor-binding N1 neuraminidases occur sporadically in several lineages and show no attenuation in cell culture or mice
Mutation
20 27849220 Surveillance of antiviral resistance markers in Argentina: detection of E119V neuraminidase mutation in a post-treatment immunocompromised patient
Mutation
21 29489060 Molecular genetic characteristics of influenza A virus clinically isolated during 2011-2016 influenza seasons in Korea
Mutation
22 30548432 Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan
Mutation
23 32004620 Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017-2018
Mutation
24 25721488 Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2013-2014
Mutation
25 22848649 Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses
Mutation
26 39802823 Comprehensive molecular epidemiology of influenza viruses in Brazil: insights from a nationwide analysis
Mutation
27 28132927 Antigenic and genetic characterization of influenza viruses circulating in Bulgaria during the 2015/2016 season
Mutation
28 32064779 Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil
Mutation
29 29145498 Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins
Mutation
30 20592084 Adaptation of pandemic H1N1 influenza viruses in mice
Mutation
31 21698272 Genomic polymorphism of the pandemic A (H1N1) influenza viruses correlates with viral replication, virulence, and pathogenicity in vitro and in vivo
Mutation
32 35446141 Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies
Mutation
33 23251479 Whole genome characterization, phylogenetic and genome signature analysis of human pandemic H1N1 virus in Thailand, 2009-2012
Mutation
34 26453960 A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice
Mutation
35 20976194 Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype?
Mutation
36 20522774 Permissive secondary mutations enable the evolution of influenza oseltamivir resistance
Mutation
37 21470455 H275Y mutant pandemic (H1N1) 2009 virus in immunocompromised patients
Mutation
38 22811535 Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation
Mutation
39 22970161 Exploring the mechanism of zanamivir resistance in a neuraminidase mutant: a molecular dynamics study
Mutation
40 25297528 Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses
Mutation
41 31697721 Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza
Mutation
42 26345289 Influenza virus surveillance in Argentina during the 2012 season: antigenic characterization, genetic analysis and antiviral susceptibility
Mutation
43 20205961 Circulation of human influenza viruses and emergence of Oseltamivir-resistant A(H1N1) viruses in Cameroon, Central Africa
Mutation
44 25297358 Antiviral drug profile of human influenza A & B viruses circulating in India: 2004-2011
Mutation
45 20345239 Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts
Mutation
46 21470465 Drug-resistant pandemic (H1N1) 2009, South Korea
Mutation
47 22013054 Amino acid changes in hemagglutinin contribute to the replication of oseltamivir-resistant H1N1 influenza viruses
Mutation
48 23442314 Spread of Influenza A(H1N1) oseltamivir-resistant viruses in Africa in 2008 confirmed by multiple introductions in Senegal
Mutation
49 28814737 Susceptibility of influenza A(H1N1)/pdm2009, seasonal A(H3N2) and B viruses to Oseltamivir in Guangdong, China between 2009 and 2014
Mutation
50 30971204 Epidemiological and genetic characterization of pH1N1 and H3N2 influenza viruses circulated in MENA region during 2009-2017
Mutation
51 31356626 Severe cases of seasonal influenza in Russia in 2017-2018
Mutation
52 32256457 Identification of Chebulinic Acid and Chebulagic Acid as Novel Influenza Viral Neuraminidase Inhibitors
Mutation
53 28802866 Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015-2016
Mutation
54 22328930 Emerged HA and NA mutants of the pandemic influenza H1N1 viruses with increasing epidemiological significance in Taipei and Kaohsiung, Taiwan, 2009-10
Mutation
55 23369604 A (H1N1) pdm09 HA D222 variants associated with severity and mortality in patients during a second wave in Mexico
Mutation
56 23927713 A(H1N1)pdm09 hemagglutinin D222G and D222N variants are frequently harbored by patients requiring extracorporeal membrane oxygenation and advanced respiratory assistance for severe A(H1N1)pdm09 infection
Mutation
57 21799795 A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase
Mutation
58 23930018 Molecular distribution of amino acid substitutions on neuraminidase from the 2009 (H1N1) human influenza pandemic virus
Mutation
59 25340711 Epidemiological and virological characteristics of influenza viruses circulating in Cambodia from 2009 to 2011
Mutation
60 39296541 Baloxavir Resistance Markers in Influenza A and B Viruses in the Americas
Mutation
61 32547518 Characterization of Influenza A and B Viruses Circulating in Southern China During the 2017-2018 Season
Mutation
62 29941893 Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
Mutation
63 31538644 Baloxavir Marboxil in Japanese Pediatric Patients With Influenza: Safety and Clinical and Virologic Outcomes
Mutation
64 29023600 Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients
Mutation
65 39037444 Structure and dynamics of the proton-selective histidine and the gating tryptophan in an inward rectifying hybrid influenza B and A virus M2 proton channel
Mutation
66 18191435 A cluster of conserved basic amino acids near the C-terminus of the PB1 subunit of the influenza virus RNA polymerase is involved in the regulation of viral transcription
Mutation
67 29691337 Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors
Mutation
68 12821478 Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir
Mutation
69 39659606 Molecular dynamics study on the effect of the N1 neuraminidase double mutant G147R/H274Y on oseltamivir sensitivity
Mutation
70 27486041 Discovery of Potential, Non-Toxic Influenza Virus Inhibitor by Computational Techniques
Mutation
71 30165308 Selection of influenza virus resistant to the novel camphor-based antiviral camphecene results in loss of pathogenicity
Mutation
72 11709315 Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants
Mutation
73 23575174 Neuraminidase inhibitor susceptibility surveillance of influenza viruses circulating worldwide during the 2011 Southern Hemisphere season
Mutation
74 12574276 Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network
Mutation
75 25043638 Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013
Mutation
76 21306576 Influenza and other respiratory viruses in three Central American countries
Mutation
77 23917311 Bioluminescence-based neuraminidase inhibition assay for monitoring influenza virus drug susceptibility in clinical specimens
Mutation
78 37404185 Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility
Mutation
79 34388979 Use of hemagglutinin and neuraminidase amplicon-based high-throughput sequencing with variant analysis to detect co-infection and resolve identical consensus sequences of seasonal influenza in a university setting
Mutation
80 39593174 Genomic surveillance and evolutionary dynamics of influenza a virus in Sri Lanka
Mutation
81 1566586 A single point mutation of the influenza C virus glycoprotein (HEF) changes the viral receptor-binding activity
Mutation
82 34745027 A Comprehensive Molecular and Epidemiological Characterization of Influenza Viruses Circulating 2016-2020 in North Macedonia
Mutation
83 37015946 Phylogenomic analysis uncovers a 9-year variation of Uganda influenza type-A strains from the WHO-recommended vaccines and other Africa strains
Mutation
84 29212936 Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9
Mutation
85 26341387 Computational assay of Zanamivir binding affinity with original and mutant influenza neuraminidase 9 using molecular docking
Mutation
86 23908028 Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus
Mutation
87 27351973 Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody
Mutation
88 31575766 Influenza Virus Polymerase Mutation Stabilizes a Foreign Gene Inserted into the Virus Genome by Enhancing the Transcription/Replication Efficiency of the Modified Segment
Mutation
89 31581279 Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer
Mutation
90 33202790 Identification of Novel Influenza Polymerase PB2 Inhibitors Using a Cascade Docking Virtual Screening Approach
Mutation
91 39817904 Probing the functional constraints of influenza A virus NEP by deep mutational scanning
Mutation
92 27376632 Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I
Mutation
93 28860626 Topological N-glycosylation and site-specific N-glycan sulfation of influenza proteins in the highly expressed H1N1 candidate vaccines
Mutation
94 26656922 A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance
Mutation
95 29199545 The inhibitory performance of flavonoid cyanidin-3-sambubiocide against H274Y mutation in H1N1 influenza virus
Mutation
96 30102858 A Small-Molecule Compound Has Anti-influenza A Virus Activity by Acting as a ''PB2 Inhibitor"
Mutation
97 19428589 Development of a novel real-time reverse-transcriptase PCR method for the detection of H275Y positive influenza A H1N1 isolates
Mutation
98 28418242 Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus
Mutation
99 20554779 Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus
Mutation
100 21040570 All that glitters is not gold--founder effects complicate associations of flu mutations to disease severity
Mutation
101 23247916 Attenuation of an influenza A virus due to alteration of its hemagglutinin-neuraminidase functional balance in mice
Mutation
102 18442378 Application of bioinformatics-coupled experimental analysis reveals a new transport-competent nuclear localization signal in the nucleoprotein of influenza A virus strain
Mutation
103 23551973 Progressive emergence of an oseltamivir-resistant A(H3N2) virus over two courses of oseltamivir treatment in an immunocompromised paediatric patient
Mutation
104 9060611 Preferential selection of receptor-binding variants of influenza virus hemagglutinin by the neutralizing antibody repertoire of transgenic mice expressing a human immunoglobulin mu minigene
Mutation
105 2295311 The structure of a membrane fusion mutant of the influenza virus haemagglutinin
Mutation
106 11071905 A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion
Mutation
107 16140782 Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion
Mutation
108 26703840 H274Y's Effect on Oseltamivir Resistance: What Happens Before the Drug Enters the Binding Site
Mutation
109 27440889 Unmasking Stem-Specific Neutralizing Epitopes by Abolishing N-Linked Glycosylation Sites of Influenza Virus Hemagglutinin Proteins for Vaccine Design
Mutation
110 35423449 Structure-based design of 5'-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors
Mutation
111 29765910 A Promising IFN-Deficient System to Manufacture IFN-Sensitive Influenza Vaccine Virus
Mutation
112 38901927 CRISPR-Based Assays for Point-of-Need Detection and Subtyping of Influenza
Mutation
113 29541360 Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants
Mutation
114 29750015 Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7
Mutation
115 37235589 Two modes of fusogenic action for influenza virus fusion peptide
Mutation
116 28251891 Mid-season real-time estimates of seasonal influenza vaccine effectiveness in persons 65 years and older in register-based surveillance, Stockholm County, Sweden, and Finland, January 2017
Mutation
117 30141905 The Stabilities of the Soluble Ectodomain and Fusion Peptide Hairpins of the Influenza Virus Hemagglutinin Subunit II Protein Are Positively Correlated with Membrane Fusion
Mutation
118 34069905 Transient Excursions to Membrane Core as Determinants of Influenza Virus Fusion Peptide Activity
Mutation
119 39488842 Activation of the Influenza B M2 Proton Channel (BM2)
Mutation
Contents
Description
Disease Group Note
  • The label in Group indicates that the disease is mentioned in mutation or integration research. Click the eye label to view the corresponding module information.