HBV VIS Detail Information

> This page shows VIS [1002174] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 1002174
VISID TVIS10014880
Chromosome chr4
GRCh38 Location 54042613, 54049074
Disease Carcinoma, Hepatocellular  
Sample Cell line
Virus Reference Genome NC_003977.1
Target Gene CHIC2  
Literature Information
PubMed PMID 24582836
Year 2014 Mar 17;25(3):335-49
Journal Cancer cell
Title Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
Author Lau CC,Sun T,Ching AK,He M,Li JW,Wong AM,Co NN,Chan AW,Li PS,Lung RW,Tong JH,Lai PB,Chan HL,To KF,Chan TF,Wong N
Evidence The mutagenic effect of hepatitis B (HBV) integration in predisposing risk to hepatocellular carcinoma (HCC) remains elusive. In this study, we performed transcriptome sequencing of HBV-positive HCC cell lines and showed transcription of viral-human gene fusions from the site of genome integrations. We discovered tumor-promoting properties of a chimeric HBx-LINE1 that, intriguingly, functions as a hybrid RNA. HBx-LINE1 can be detected in 23.3% of HBV-associated HCC tumors and correlates with poorer patient survival. HBx-LINE1 transgenic mice showed heightened susceptibility to diethylnitrosamine-induced tumor formation. We further show that HBx-LINE1 expression affects beta-catenin transactivity, which underlines a role in activating Wnt signaling. Thus, this study identifies a viral-human chimeric fusion transcript that functions like a long noncoding RNA to promote HCC.
Contents
Description
  • Site Information
Detail information of site [1002174]
  • Literature Information
The details of literature that this site is associated with.