HBV VIS Detail Information

> This page shows VIS [1041146] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	1041146
Chromosome	chr16
GRCh38 Location	10895797
Disease	Carcinoma, Hepatocellular
Sample	adjacent
Virus Reference Genome	AY123041
Target Gene	CIITA

Literature Information

PubMed PMID	37268616
Year	2023 Jun 2;8(1):11
Journal	NPJ Genom Med
Title	Characteristics of Hepatitis B virus integration and mechanism of inducing chromosome translocation
Author	Xiaofang Cui, Yiyan Li, Hanshi Xu, Yuhui Sun, Shulong Jiang, Weiyang Li
Evidence	Hepatitis B virus (HBV) integration is closely associated with the onset and progression of tumors. This study utilized the DNA of 27 liver cancer samples for high-throughput Viral Integration Detection (HIVID), with the overarching goal of detecting HBV integration. KEGG pathway analysis of breakpoints was performed using the ClusterProfiler software. The breakpoints were annotated using the latest ANNOVAR software. We identified 775 integration sites and detected two new hotspot genes for virus integration, N4BP1 and WASHP, along with 331 new genes. Furthermore, we conducted a comprehensive analysis to determine the critical impact pathways of virus integration by combining our findings with the results of three major global studies on HBV integration. Meanwhile, we found common characteristics of virus integration hotspots among different ethnic groups. To specify the direct impact of virus integration on genomic instability, we explained the causes of inversion and the frequent occurrence of translocation due to HBV integration. This study detected a series of hotspot integration genes and specified common characteristics of critical hotspot integration genes. These hotspot genes are universal across different ethnic groups, providing an effective target for better research on the pathogenic mechanism. We also demonstrated more comprehensive key pathways affected by HBV integration and elucidated the mechanism for inversion and frequent translocation events due to virus integration. Apart from the great significance of the rule of HBV integration, the current study also provides valuable insights into the mechanism of virus integration.