HIV VIS Detail Information

> This page shows VIS [4001428] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	4001428
VISID	TVIS30015360
Chromosome	chr16
GRCh38 Location	67032095, 67032219
Disease	HIV Infections Acquired Immunodeficiency Syndrome
Sample	PBMC
Virus Reference Genome	Not given
Target Gene	CBFB

Literature Information

PubMed PMID	24968937
Year	2014 Jul 11;345(6193):179-83
Journal	Science (New York, N.Y.)
Title	HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.
Author	Maldarelli F,Wu X,Su L,Simonetti FR,Shao W,Hill S,Spindler J,Ferris AL,Mellors JW,Kearney MF,Coffin JM,Hughes SH
Evidence	The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted for many years. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.