HIV VIS Detail Information

> This page shows VIS [4017131] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

DVID	4017131
Chromosome	chr1
GRCh38 Location	143178830, 143328870
Disease	HIV Infections Acquired Immunodeficiency Syndrome

Literature Information

PubMed PMID	33823910
Year	2021 Apr 6;22(1):97
Journal	Genome biology
Title	PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads.
Author	Artesi M,Hahaut V,Cole B,Lambrechts L,Ashrafi F,Marcais A,Hermine O,Griebel P,Arsic N,van der Meer F,Burny A,Bron D,Bianchi E,Delvenne P,Bours V,Charlier C,Georges M,Vandekerckhove L,Van den Broeke A,Durkin K
Evidence	The integration of a viral genome into the host genome has a major impact on the trajectory of the infected cell. Integration location and variation within the associated viral genome can influence both clonal expansion and persistence of infected cells. Methods based on short-read sequencing can identify viral insertion sites, but the sequence of the viral genomes within remains unobserved. We develop PCIP-seq, a method that leverages long reads to identify insertion sites and sequence their associated viral genome. We apply the technique to exogenous retroviruses HTLV-1, BLV, and HIV-1, endogenous retroviruses, and human papillomavirus.