HPV VIS Detail Information

> This page shows VIS [5003880] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.


Site Information
DVID 5003880
VISID TVIS20004557
Chromosome chr7
GRCh38 Location 54076318, 54076346
Disease Uterine Cervical Neoplasms  
Sample Cell line
Virus Reference Genome NC_001526.2
Literature Information
PubMed PMID 24201445
Year 2014 Feb;24(2):185-99
Journal Genome research
Title Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.
Author Akagi K,Li J,Broutian TR,Padilla-Nash H,Xiao W,Jiang B,Rocco JW,Teknos TN,Kumar B,Wangsa D,He D,Ried T,Symer DE,Gillison ML
Evidence Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of """"looping"""" by which HPV integrant-mediated DNA replication and recombination may result in viral-host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability.
Contents
Description
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Detail information of site [5003880]
  • Literature Information
The details of literature that this site is associated with.