Gene Name	EIF4G1
Gene ID	1981
Gene Full Name	eukaryotic translation initiation factor 4 gamma 1
Gene Alias	EIF-4G1|EIF4F|EIF4G|EIF4GI|P220|PARK18
Transcripts	ENSG00000114867
Virus	XMRV
Gene Type	protein-coding
HPA Location Info	Cytosol;
Membrane Info	Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q04637
HGNC ID	HGNC:3296
OMIM ID	600495
Summary	The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
8000047	chr3	6095	3544	1808	11447	View