Gene Name	EP300
Gene ID	2033
Gene Full Name	E1A binding protein p300
Gene Alias	KAT3B|MKHK2|RSTS2|p300
Transcripts	ENSG00000100393
Virus	HDV
Gene Type	protein-coding
HPA Location Info	Nucleoplasm;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	Q09472
HGNC ID	HGNC:3373
OMIM ID	602700
Summary	This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	14967488	K72R	S-HDAg	sHD	Cell line	D T	View