Gene Information
|
Gene Name
|
GRM1 |
|
Gene ID
|
2911
|
|
Gene Full Name
|
glutamate metabotropic receptor 1 |
|
Gene Alias
|
GPRC1A|MGLU1|MGLUR1|PPP1R85|SCA44|SCAR13 |
|
Transcripts
|
ENSG00000152822
|
|
Virus
|
HBV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Vesicles; 
|
|
Membrane Info
|
Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters |
|
Uniport_ID
|
Q13255
|
|
HGNC ID
|
HGNC:4593
|
|
OMIM ID
|
604473 |
|
Summary
|
This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013] |
Target gene [GRM1] related to VISs 
Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section
| DVID |
Chromosome |
HM |
TFBS |
CA |
Sum of Overlapped Records |
Detail |
| 1005039 |
chr6 |
6 |
22 |
35 |
63 |
View |
| 1012465 |
chr6 |
3 |
4 |
0 |
7 |
View |
| 1018602 |
chr6 |
0 |
0 |
0 |
0 |
View |
| 1043195 |
chr6 |
0 |
1 |
0 |
1 |
View |
Target gene [GRM1] related to Omics data
| Data ID |
Experiment type |
Sample number |
Platform |
|
GSE236281
|
RNA-seq |
12 |
Illumina MiSeq (Homo sapiens) |
|
C GSE68402
|
Chip-seq |
26 |
Illumina MiSeq (Homo sapiens);Illumina HiSeq 2500 (Homo sapiens) |
|
TCGA_LIHC_HBV
|
DNA methylation sequencing;RNA-seq |
97 |
TCGA |
|
GSE224901
|
RNA-seq |
21 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
C GSE100400
|
Chip-seq;RNA-seq;4C_cccDNA |
31 |
Illumina NextSeq 500 (Homo sapiens);Illumina NextSeq 500 (Mus musculus) |
|
GSE173897
|
RNA-seq |
95 |
Illumina HiSeq 4000 (Homo sapiens) |
|
GSE262515
|
RNA-seq |
21 |
Illumina HiSeq 2500 (Homo sapiens);Illumina HiSeq 2500 (Mus musculus) |
|
GSE110345
|
RNA-seq |
4 |
Illumina HiSeq 2500 (Homo sapiens) |
|
C GSE131257
|
ATAC-seq;RNA-seq |
19 |
Illumina HiSeq 2500 (Homo sapiens) |
|
GSE94660
|
RNA-seq |
42 |
Illumina HiSeq 2500 (Homo sapiens) |
When the gene can detect a peak in the dataset, a peak plot will be displayed.
> Dataset: GSE68402 - GRM1 peak across samples
|
Peak Plot
|
> Dataset: GSE100400 - GRM1 peak across samples
|
Peak Plot
|
> Dataset: GSE131257 - GRM1 peak across samples
|
Peak Plot
|
|
|
HBV Target gene Detail Information
