Gene Name	IFNA1
Gene ID	3439
Gene Full Name	interferon alpha 1
Gene Alias	IFL|IFN|IFN-ALPHA|IFN-alphaD|IFNA13|IFNA@|leIF D
Transcripts	ENSG00000197919
Virus	CCHFV
Gene Type	protein-coding
HPA Location Info	Secreted to blood;
Membrane Info	Cancer-related genes, Plasma proteins, Predicted secreted proteins
Uniport_ID	P01562
HGNC ID	HGNC:5417
OMIM ID	147660
Summary	This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia. [provided by RefSeq, Aug 2020]

Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section

ID	PMID	Mutation	Gene/Protein/Region	Encoding Gene/Protein	Disease	Description	Detail
1	32931521	C40A	L	L	Cell line	I T	View

Data ID	Experiment type	Sample number	Platform
GSE133086	RNA-seq	24	Illumina HiSeq 4000 (Homo sapiens)