Gene Name	IGH
Gene ID	3492
Gene Full Name	immunoglobulin heavy locus
Gene Alias	IGD1|IGH.1@|IGH@|IGHD@|IGHDY1|IGHJ|IGHJ@|IGHV|IGHV@
Virus	HIV
Gene Type	protein-coding
HGNC ID	HGNC:5477
OMIM ID	147070
Summary	Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Due to polymorphism, the numbers of functional V, J, and D genes differ among individuals and some V, D, J, and C segments may be pseudogenes. [provided by RefSeq, Dec 2017]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000720	chr14	301	0	2	303	View
4001236	chr14	103	86	1	190	View
4004862	chr14	38	0	0	38	View
4005535	chr14	31	0	0	31	View
4009014	chr14	13	0	0	13	View
4011570	chr14	3	2	1	6	View
4014600	chr14	0	2	0	2	View
4015041	chr14	1	0	0	1	View
4015276	chr14	1	0	0	1	View
4015277	chr14	1	0	0	1	View
4015278	chr14	0	1	0	1	View
4016494	chr14	0	0	0	0	View