Gene Information
|
Gene Name
|
IRF1 |
|
Gene ID
|
3659
|
|
Gene Full Name
|
interferon regulatory factor 1 |
|
Gene Alias
|
IMD117|IRF-1|MAR |
|
Transcripts
|
ENSG00000125347
|
|
Virus
|
CHIKV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
|
Nucleoplasm;Cytosol; 
|
|
Membrane Info
|
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
|
Uniport_ID
|
P10914
|
|
HGNC ID
|
HGNC:6116
|
|
OMIM ID
|
147575 |
|
Summary
|
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017] |
Target gene [IRF1] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
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CHIKV Target gene Detail Information
