Gene Information
|
Gene Name
|
JAK1 |
|
Gene ID
|
3716
|
|
Gene Full Name
|
Janus kinase 1 |
|
Gene Alias
|
AIIDE|JAK1A|JAK1B|JTK3 |
|
Transcripts
|
ENSG00000162434
|
|
Virus
|
MARV |
|
Gene Type
|
protein-coding |
|
HPA Location Info
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|
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Membrane Info
|
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
|
Uniport_ID
|
P23458
|
|
HGNC ID
|
HGNC:6190
|
|
OMIM ID
|
147795 |
|
Summary
|
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020] |
Target gene [JAK1] related to virus gene/protein/region 
Mutation Table: if previous studies reported that target gene was related to virus gene/region/protein, the information in this literature was listed in this section
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MARV Target gene Detail Information
