Gene Name	MET
Gene ID	4233
Gene Full Name	MET proto-oncogene, receptor tyrosine kinase
Gene Alias	AUTS9|DA11|DFNB97|HGFR|RCCP2|c-Met
Transcripts	ENSG00000105976
Virus	XMRV
Gene Type	protein-coding
HPA Location Info	Plasma membrane;Cytosol;Secreted to blood;
Membrane Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins, Transporters
Uniport_ID	P08581
HGNC ID	HGNC:7029
OMIM ID	164860
Summary	This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in this section

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
8000051	chr7	2585	1864	1027	5476	View